55:
65:
31:
122:. These lesions characteristically consist of polygonal cells with bland nuclei, abundant cytoplasm and fine eosinophilic cytoplasmic granules. The tumor cells stain positively for S-100 as they are of Schwann cell origin. Both malignant and benign versions of the tumor exist, where malignant tumors are characterized histologically by features such as spindling, high nuclear to cytoplasmic ratios, pleomorphism, and necrosis.
162:
are deemed clear of tumor infiltration. When the resection margins of a benign granular cell tumor are positive for tumor infiltration the recurrence rate is increased to 20%. Malignant lesions are aggressive and difficult to eradicate with surgery and have a recurrence rate of 32%.
474:
217:. Granular cell tumors are typically solitary and rarely larger than three centimeters. However, proliferative growth and development of an ulcer indicates likely malignancy as this type of tumor can be either
562:
339:
Schrader, KA.; Nelson, TN.; De Luca, A.; Huntsman, DG.; McGillivray, BC. (Feb 2009). "Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11".
171:
Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (
445:
Fanburg-Smith JC, Meis-Kindblom JM, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. Jul 1998;22(7):779-94.
555:
548:
187:(10%). Granular cell tumors are also found in the internal organs, particularly in the upper aerodigestive tract. Vaginal granular cell tumors are generally rare.
490:
198:, granular cell tumors are mostly found in the upper inner quadrant of the breast. They can be erroneously diagnosed as an invasive ductal carcinoma via
394:. Gibbs, Ronald S., 1943-, Danforth, David N. (David Newton), 1912-1990. (10th ed.). Philadelphia: Lippincott Williams & Wilkins. 2008.
1055:
190:
Breast granular cell tumors arise from intralobular breast stroma and occurs within the distribution of the cutaneous branches of the
194:. As they do follow the innervation of the skin, they may demonstrate skin changes like contraction or shrinkage. Unlike traditional
143:
These tumors, on occasion, may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue neoplasms.
1636:
1362:
275:
436:
Aoyama, K., Kamio, T., Hirano, A. et al. Granular cell tumors: a report of six cases. World J Surg Onc. Sep 2012;10(204)
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213:
The usual presentation is of a slow growing behavior, forming a polygonal accumulation of secondary lysosomes in the
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1341:
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292:"Granular cell tumor | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program"
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115:
183:). The next most common location that lesions are found in the head and neck area is the
8:
1551:
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are not needed for benign lesions and are not effective for malignant lesions.
114:
Granular cell tumors are derived from neural tissue, as can be demonstrated by
64:
1625:
1586:
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1516:
1478:
1346:
1213:
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195:
1531:
1103:
1083:
898:
893:
883:
724:
360:
325:
152:
225:. Malignancy is rare and constitutes only 2% of all granular cell tumors.
151:
The primary method for treatment is surgical, not medical. Radiation and
1566:
1391:
1093:
759:
203:
180:
176:
381:
Kahn, Michael A. Basic Oral and
Maxillofacial Pathology. Volume 1. 2001.
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316:
Neelon, D.; Lannan, F.; Childs, J. (Jan 2020). "Granular Cell Tumor".
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214:
38:
2-cm tumor presented as an abdominal wall mass in a middle-aged woman
158:
Benign granular cell tumors have a recurrence rate of 2% to 8% when
106:. Granular cell tumors (GCTs) affect females more often than males.
1596:
1218:
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266:
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
206:, therefore, it is necessary to consider a diagnosis of invasive
1007:
952:
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478:
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125:
Multiple granular cell tumors may seen in the context of
68:
Histopathologic image of granular cell tumor of the skin
456:
315:
571:Diseases of the skin and appendages by morphology
1623:
1056:Pityriasis lichenoides et varioliformis acuta
556:
710:Dermatofibroma (benign fibrous histiocytoma)
296:Genetic and rare diseases information center
332:
309:
563:
549:
261:
259:
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53:
29:
270:. St. Louis: Mosby. pp. 1796, 1804.
63:
252:
1624:
1363:Disseminated intravascular coagulation
83:or mucosal surface, but occurs on the
544:
392:Danforth's obstetrics and gynecology
118:and ultrastructural evidence using
13:
1188:
1145:Postinflammatory hyperpigmentation
14:
1648:
1046:Transient acantholytic dermatosis
452:
1155:Idiopathic guttate hypomelanosis
353:10.1111/j.1399-0004.2008.01100.x
100:granular cell nerve sheath tumor
1637:Dermal and subcutaneous growths
1165:Hypopigmented mycosis fungoides
166:
1406:Lichen sclerosis et atrophicus
1114:Subcorneal pustular dermatosis
740:Infantile digital fibromatosis
439:
430:
384:
375:
284:
1:
998:Epidermolysis bullosa simplex
835:Langerhans cell histiocytosis
245:
1474:Systemic lupus erythematosus
1229:Systemic lupus erythematosus
920:Systemic lupus erythematosus
235:List of cutaneous conditions
146:
109:
7:
755:Lymphangioma circumscriptum
228:
131:, due to a mutation in the
10:
1653:
1577:Mucous membrane pemphigoid
1540:
1507:
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1325:
1278:
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1206:
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781:
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651:
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268:Dermatology: 2-Volume Set
96:granular cell myoblastoma
42:
37:
28:
23:
1342:Thrombocytopenic purpura
988:Dermatitis herpetiformis
973:Acute contact dermatitis
925:Pityriasis rubra pilaris
850:Wiskott–Aldrich syndrome
820:Lichen simplex chronicus
700:Epidermal inclusion cyst
104:granular cell schwannoma
79:that can develop on any
1607:Squamous-cell carcinoma
1602:Systemic histoplasmosis
993:Porphyria cutanea tarda
623:Squamous-cell carcinoma
1582:Cicatricial pemphigoid
1499:Acne keloidalis nuchae
1494:Folliculitis decalvans
422:: CS1 maint: others (
69:
1484:Loose anagen syndrome
1411:Necrobiosis lipoidica
1347:Actinic/solar purpura
1021:Insect bite reactions
810:Seborrheic dermatitis
633:Merkel-cell carcinoma
613:Molluscum contagiosum
240:Glassy cell carcinoma
192:supraclavicular nerve
67:
1307:Annulare centrifugum
830:Glucagonoma syndrome
628:Basal-cell carcinoma
603:Seborrheic keratosis
116:immunohistochemistry
90:It is also known as
1552:Aphthous stomatitis
1489:Lichen planopilaris
1464:Androgenic alopecia
1270:Fixed drug eruption
845:Pemphigus foliaceus
745:Granular cell tumor
120:electron microscopy
92:Abrikossoff's tumor
73:Granular cell tumor
24:Granular cell tumor
1572:Pemphigus vulgaris
1401:Granuloma annulare
1265:Carcinoid syndrome
1150:Tuberous sclerosis
1109:Coccidioidomycosis
983:Bullous pemphigoid
978:Pemphigus vulgaris
910:Secondary syphilis
800:Contact dermatitis
70:
1619:
1618:
1615:
1614:
1459:Telogen effluvium
1423:
1422:
1419:
1418:
1380:
1379:
1376:
1375:
1321:
1320:
1173:
1172:
1041:Lichen spinulosus
1036:Keratosis pilaris
915:Mycosis fungoides
815:Stasis dermatitis
805:Atopic dermatitis
768:
767:
643:Trichoepithelioma
618:Actinic keratosis
538:
537:
277:978-1-4160-2999-1
160:resection margins
87:40% of the time.
62:
61:
18:Medical condition
1644:
1557:Oral candidiasis
1434:
1433:
1332:
1331:
1260:Erythema nodosum
1204:
1203:
1193:
1192:
1186:
1185:
1130:Tinea versicolor
968:Bullous impetigo
905:Pityriasis rosea
840:Lichen sclerosus
825:Darier's disease
790:
789:
779:
778:
735:Kaposi's sarcoma
581:
580:
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208:ductal carcinoma
128:LEOPARD syndrome
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33:
21:
20:
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1469:Alopecia areata
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1429:
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1219:Viral exanthems
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1181:
1179:
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1140:Pityriasis alba
1118:
1060:
1002:
939:
859:
855:Zinc deficiency
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638:Nevus sebaceous
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1632:Oral neoplasia
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1302:Gyratum repens
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1224:Toxic erythema
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1214:Drug eruptions
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1096:
1091:
1086:
1081:
1076:
1070:
1068:
1062:
1061:
1059:
1058:
1053:
1051:Lichen nitidus
1048:
1043:
1038:
1033:
1028:
1023:
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1012:
1010:
1004:
1003:
1001:
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953:Herpes simplex
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461:Classification
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196:breast cancers
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26:
25:
17:
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1562:Lichen planus
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1549:
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1517:Onychomycosis
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1510:
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1500:
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1479:Tinea capitis
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1428:Miscellaneous
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1148:
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1123:Hypopigmented
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1074:Acne vulgaris
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1052:
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1026:Lichen planus
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1532:Ingrown nail
1104:Dermatophyte
1099:Gonococcemia
1084:Folliculitis
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725:Neurofibroma
693:subcutaneous
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347:(2): 185–9.
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299:. Retrieved
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167:Epidemiology
157:
153:chemotherapy
150:
142:
132:
126:
124:
113:
103:
99:
95:
91:
89:
72:
71:
15:
1587:Herpesvirus
1567:Leukoplakia
1392:Scleroderma
1279:Specialized
1207:Generalized
1182:involvement
1094:Candidiasis
786:involvement
760:Myxoid cyst
608:Acrochordon
204:mammography
181:hard palate
177:oral mucosa
1626:Categories
1527:Paronychia
1368:Vasculitis
1292:Multiforme
1290:Erythema (
1245:Cellulitis
1196:Blanchable
945:Blistering
935:Ichthyosis
793:Eczematous
705:Hemangioma
513:DiseasesDB
341:Clin Genet
318:StatPearls
246:References
200:ultrasound
1522:Psoriasis
1430:disorders
1385:Indurated
1286:Urticaria
1238:Localized
1180:epidermal
963:Varicella
873:Psoriasis
784:epidermal
750:Leiomyoma
652:Pigmented
585:Epidermal
524:SNOMED CT
482:: D36.1 (
418:cite book
410:187289377
369:205407005
223:malignant
215:cytoplasm
147:Treatment
110:Pathology
44:Specialty
1597:Syphilis
1544:membrane
1199:Erythema
1135:Vitiligo
1089:Impetigo
1066:Pustular
1031:Miliaria
879:Corporis
730:Xanthoma
679:Melanoma
659:Freckles
529:12169001
486:D36.170)
361:19054014
326:33085297
301:17 April
229:See also
49:Oncology
1396:morphea
1356:Papular
1335:Macular
1328:Purpura
1312:Ab igne
1297:Migrans
1250:Abscess
1178:Without
1160:Leprosy
1079:Rosacea
1016:Scabies
1008:Papular
877:Tinea (
865:Scaling
669:Melasma
664:Lentigo
577:Growths
507:D016586
496:M9582/0
1542:Mucous
1438:Ulcers
899:Faciei
894:Manuum
884:Cruris
774:Rashes
720:Lipoma
715:Keloid
689:Dermal
598:Callus
408:
398:
367:
359:
324:
274:
219:benign
185:larynx
173:tongue
134:PTPN11
102:, and
85:tongue
51:
889:Pedis
674:Nevus
518:31674
491:ICD-O
365:S2CID
77:tumor
75:is a
1509:Nail
1452:Hair
1255:Boil
782:With
593:Wart
502:MeSH
484:ILDS
424:link
406:OCLC
396:ISBN
357:PMID
322:PMID
303:2018
272:ISBN
202:and
137:gene
81:skin
1189:Red
691:and
475:ICD
349:doi
221:or
210:.
1628::
527::
516::
505::
494::
479:10
420:}}
416:{{
404:.
363:.
355:.
345:75
343:.
320:.
294:.
254:^
179:,
175:,
140:.
98:,
94:,
1394:/
1314:)
901:)
564:e
557:t
550:v
477:-
467:D
426:)
412:.
371:.
351::
328:.
305:.
280:.
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