2179:
418:). Hence, this calcium increase triggers the calcium-dependent association of gpIIb and gpIIIa to form the activated membrane receptor complex gpIIb/IIIa, which is capable of binding fibrinogen (factor I), resulting in many platelets "sticking together" as they may connect to the same strands of fibrinogen, resulting in a clot. The
503:
Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin".
374:) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including
366:. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by
410:
fashion (binds both itself and other platelets). The binding of these receptors result in a cascade of events resulting in an increase in intracellular calcium (e.g. via G
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1968:
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Bellucci S, Caen J (September 2002). "Molecular basis of
Glanzmann's Thrombasthenia and current strategies in treatment".
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Calvete JJ (April 1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor".
363:
227:
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Shattil SJ (August 1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways".
1700:
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2011:
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426:(factor IIa) converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by
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receptor activation leading to Ca release from platelet endoplasmic reticulum Ca stores, which may activate
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McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura".
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Once platelets are activated, granules secrete clotting mediators, including both
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integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
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1632:
399:
402:. These then bind their respective receptors on platelet surfaces, in both an
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can be used to prevent blood clots in an effort to decrease the risk of
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Proceedings of the
Society for Experimental Biology and Medicine
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Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
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integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
1974:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
445:Autoantibodies against IIb/IIIa can be produced in
2040:Thrombin-activatable fibrinolysis inhibitor (TAFI)
2100:Activated protein C–protein C inhibitor (APC–PCI)
2235:
1949:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
422:cascade then follows to stabilize the clot, as
389:
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2017:Plasminogen activator inhibitor-2 (PAI-2)
2012:Plasminogen activator inhibitor-1 (PAI-1)
700:at the U.S. National Library of Medicine
659:
1715:
581:
538:
502:
438:Defects in glycoprotein IIb/IIIa cause
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1810:High-molecular-weight kininogen (HMWK)
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711:
354:. It is a transmembrane receptor for
2173:
2095:Thrombin–antithrombin complex (TAT)
18:Integrin complex found on platelets
13:
2002:Tissue plasminogen activator (tPA)
1959:Protein S (cofactor for protein C)
1676:cell surface receptor deficiencies
674:10.1053/j.seminhematol.2007.11.002
14:
2265:
691:
430:to form a stabilized blood clot.
2177:
482:Glycoprotein IIb/IIIa inhibitors
458:Glycoprotein IIb/IIIa inhibitors
2090:Prothrombin fragment 1+2 (F1+2)
1750:Platelet membrane glycoproteins
447:immune thrombocytopenic purpura
2254:Human chromosome 17 gene stubs
1954:Protein C (inhibits FV, FVIII)
1:
1288:
639:10.1016/S0268-960X(02)00030-9
487:
2244:Genes on human chromosome 17
2197:. You can help Knowledge by
1536:Leukocyte-adhesion receptor:
433:
390:gpIIb/IIIa complex formation
7:
1830:Factor XII (Hageman factor)
1744:von Willebrand factor (vWF)
1595:Very late antigen receptor:
553:10.3181/00379727-208-43863a
475:
452:
10:
2270:
2172:
2150:-antiplasmin complex (PAP)
1865:Factor III (tissue factor)
1196:Lymphocyte homing receptor
584:Thrombosis and Haemostasis
440:Glanzmann's thrombasthenia
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2072:β-Thromboglobulin (β-TG)
1228:Carcinoembryonic antigen
1082:Unconventional/ungrouped
702:Medical Subject Headings
2067:Platelet factor 4 (PF4)
1964:Protein Z (inhibits FX)
1898:Prothrombin (factor II)
743:cell adhesion molecules
2123:Fibrinopeptide B (FpB)
2118:Fibrinopeptide A (FpA)
1790:Glycoprotein VI (GPVI)
1755:Glycoprotein Ib (GPIb)
698:Glycoproteins+IIb-IIIa
662:Seminars in Hematology
596:10.1055/s-0037-1615849
518:10.1080/09537109976077
1941:Anticoagulant factors
1908:Fibrinogen (factor I)
1903:Thrombin (factor IIa)
1775:Glycoprotein IIb/IIIa
1769:Glycoprotein IX (GP9)
1736:(platelet activation)
1647:Vitronectin receptor:
1510:Fibronectin receptor:
1463:Glycoprotein IIb/IIIa
1451:Cytoadhesin receptor:
935:Glycoprotein IIb/IIIa
668:(4 Suppl 5): S3–S11.
360:von Willebrand factor
329:glycoprotein IIb/IIIa
2128:Fibrin monomers (FM)
1984:Fibrinolytic factors
1802:(contact activation)
1638:Integrin alpha6beta1
1612:Integrin alpha3beta1
1607:Integrin alpha2beta1
1602:Integrin alpha1beta1
1575:Integrin alphaXbeta2
1559:Macrophage-1 antigen
1527:Integrin alpha5beta1
1522:Integrin alpha4beta1
1517:Integrin alpha2beta1
1490:Macrophage-1 antigen
1483:Fibrinogen receptor:
1458:Integrin alpha6beta4
907:Macrophage-1 antigen
893:Integrin alphaXbeta2
2082:Thrombin generation
2059:Platelet activation
2050:Coagulation markers
1725:Coagulation factors
1717:Coagulation cascade
772:Myelin protein zero
751:Calcium-independent
364:platelet activation
2185:This article on a
1922:Fibrin (factor Ia)
1734:Primary hemostasis
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2110:Fibrin generation
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1855:Extrinsic pathway
1800:Intrinsic pathway
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416:Protein Kinase C
335:, also known as
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1857:(tissue factor)
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2035:-Macroglobulin
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1659:Alpha-v beta-5
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1654:Alpha-v beta-3
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1633:Alpha-5 beta-1
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692:External links
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633:(3): 193–202.
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1074:
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1056:
1055:Protocadherin
1052:
1045:
1041:
1037:
1033:
1030:
1027:
1023:
1019:
1015:
1011:
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868:
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832:
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827:
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695:
683:
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648:
644:
640:
636:
632:
628:
627:Blood Reviews
621:
613:
609:
605:
601:
597:
593:
590:(2): 318–25.
589:
585:
578:
570:
566:
562:
558:
554:
550:
547:(4): 346–60.
546:
542:
535:
527:
523:
519:
515:
512:(4): 228–37.
511:
507:
499:
497:
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483:
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48:
44:
41:
38:
34:
29:
26:
22:
16:
2199:expanding it
2184:
2169:
2155:D-Dimer (DD)
2138:Fibrinolysis
2026:-Antiplasmin
1774:
1748:
1673:
1462:
1209:
934:
665:
661:
655:
630:
626:
620:
587:
583:
577:
544:
540:
534:
509:
505:
466:heart attack
456:
444:
437:
393:
380:eptifibatide
370:(blocked by
336:
332:
328:
321:biochemistry
318:
276:
195:Alt. symbols
127:
46:Alt. symbols
15:
1992:Plasminogen
1927:Factor XIII
1845:Factor VIII
1032:Desmocollin
428:factor XIII
420:coagulation
372:clopidogrel
362:, and aids
298:Swiss-model
180:Identifiers
149:Swiss-model
31:Identifiers
2238:Categories
1870:Factor VII
1825:Kallikrein
1815:Bradykinin
1205:L-selectin
1176:P-selectin
1171:L-selectin
1166:E-selectin
1089:T-cadherin
1010:Desmoglein
1002:Desmosomal
488:References
356:fibrinogen
337:integrin α
333:GPIIb/IIIa
294:Structures
289:Search for
263:Other data
145:Structures
140:Search for
114:Other data
2249:Integrins
2189:on human
2146:Plasmin-α
2007:Urokinase
1840:Factor IX
1835:Factor XI
1674:see also
1290:Integrins
1158:Selectins
975:Classical
967:Cadherins
871:Integrins
802:L1 family
506:Platelets
462:abciximab
434:Pathology
408:paracrine
404:autocrine
384:tirofiban
376:abciximab
352:platelets
245:NM_000212
204:NCBI gene
96:NM_000419
55:NCBI gene
1893:Factor V
1888:Factor X
1211:integrin
760:IgSF CAM
682:18096470
647:12163005
612:83902334
604:10605720
526:16801097
476:See also
453:Medicine
424:thrombin
348:integrin
346:) is an
325:medicine
308:InterPro
159:InterPro
1997:Plasmin
569:9298838
561:7535429
304:Domains
274:Chr. 17
252:UniProt
155:Domains
125:Chr. 17
103:UniProt
1784:GPIIIa
1468:ITGA2B
1444:Dimers
1073:PCDH19
1068:PCDH15
939:ITGA2B
829:Nectin
807:L1-CAM
797:PE-CAM
792:VCAM-1
704:(MeSH)
680:
645:
610:
602:
567:
559:
524:
470:stroke
382:, and
278:q21.32
257:P05106
240:RefSeq
233:173470
185:Symbol
129:q21.32
108:P08514
91:RefSeq
84:607759
40:ITGA2B
36:Symbol
2193:is a
1779:GPIIb
1764:GP1BB
1759:GP1BA
1622:CD49d
1617:VLA-4
1580:CD11c
1564:CD11b
1548:CD11a
1543:LFA-1
1495:CD11b
1472:ITGB3
1297:Alpha
1248:EpCAM
1243:CD146
1220:LFA-1
1216:VLA-4
1189:Other
1144:CDH10
1134:CDH17
1129:CDH16
1124:CDH15
1119:CDH12
1114:CDH11
1063:PCDH1
943:ITGB3
925:CD49d
921:VLA-4
911:CD11b
897:CD11c
883:CD11a
879:LFA-1
859:CD155
854:CADM3
849:CADM1
844:PVRL3
839:PVRL2
834:PVRL1
817:NFASC
812:NRCAM
768:N-CAM
608:S2CID
565:S2CID
460:like
269:Locus
189:ITGB3
120:Locus
2195:stub
2187:gene
1626:CD29
1584:CD18
1568:CD18
1552:CD18
1499:CD18
1393:Beta
1238:CD44
1233:CD24
1200:CD44
1139:CDH9
1109:CDH8
1104:CDH6
1099:CDH5
1094:CDH4
1044:DSC3
1040:DSC2
1036:DSC1
1026:DSG4
1022:DSG3
1018:DSG2
1014:DSG1
992:CDH3
987:CDH2
982:CDH1
929:CD29
915:CD18
901:CD18
887:CD18
822:CHL1
778:ICAM
678:PMID
643:PMID
600:PMID
557:PMID
522:PMID
406:and
400:TXA2
398:and
358:and
323:and
228:OMIM
221:6156
216:HGNC
209:3690
198:GP3A
79:OMIM
72:6138
67:HGNC
60:3674
49:GP2B
1916:FGG
1912:FGA
1354:A11
1349:A10
670:doi
635:doi
592:doi
549:doi
545:208
514:doi
468:or
396:ADP
368:ADP
339:IIb
319:In
2240::
1914:,
1435:B8
1430:B7
1425:B6
1420:B5
1415:B4
1410:B3
1405:B2
1400:B1
1384:AX
1379:AV
1374:AM
1369:AL
1364:AE
1359:AD
1344:A9
1339:A8
1334:A7
1329:A6
1324:A5
1319:A4
1314:A3
1309:A2
1304:A1
1218:,
1198::
1042:,
1038:,
1024:,
1020:,
1016:,
784:,
741::
676:.
666:44
664:.
641:.
631:16
629:.
606:.
598:.
588:82
586:.
563:.
555:.
543:.
520:.
510:10
508:.
495:^
472:.
449:.
442:.
386:.
378:,
327:,
2226:e
2219:t
2212:v
2201:.
2148:2
2033:2
2031:α
2024:2
2022:α
1918:)
1910:(
1786:)
1777:(
1771:)
1757:(
1752::
1709:e
1702:t
1695:v
1624:+
1582:+
1566:+
1550:+
1497:+
1470:+
1282:e
1275:t
1268:v
1222:)
1214:(
1046:)
1034:(
1028:)
1012:(
945:)
941:+
937:(
931:)
927:+
923:(
917:)
913:+
909:(
903:)
899:+
895:(
889:)
885:+
881:(
788:)
786:5
782:1
780:(
774:)
770:(
731:e
724:t
717:v
684:.
672::
649:.
637::
614:.
594::
571:.
551::
528:.
516::
412:q
343:3
341:β
331:(
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