297:
274:
196:
171:
548:
303:
202:
1447:, impacting neural differentiation, growth, and circuit organization. The expression of the beta-3 subunit reaches peak at different times in different locations of the brain, during development. The highest expression of Gabrb3 in mice, within the cerebral cortex and hippocampus are reached prenatally, while they are reached postnatally in the cerebellar cortex. After the highest peak of expression, Gabrb3 expression is down-regulated substantially in the
1556:
region displayed in autistic patients are almost always of maternal origin (not paternal) and account for 1–2% of diagnosed autism disorder cases. This gene is also a candidate for autism because of the physiological response that benzodiazepine has on the GABA-A receptor, when used to treat seizures and anxiety disorders.
1559:
The Gabrb3 gene deficient mouse has been proposed as a model of autism spectrum disorder. These mice exhibit similar phenotypic symptoms such as non-selective attention, deficits in a variety of exploratory parameters, sociability, social novelty, nesting and lower rearing frequency as can be equated
1489:
by cAMP-dependent protein kinase (PKA) has a regulatory effect dependent on the beta subunit involved. The mechanism by which the kinase is targeted towards the bata-3 subunit is unknown. AKAP79/150 binds directly to the GABRB3 subunit, which is critical for its own phosphorylation, mediated by PKA.
1555:
Duplications of the Prader-Willi/Angelman syndrome region, also known as the imprinting region (15q11-13) that encompasses the GABRB3 gene are present in some patients diagnosed with Autism. These patients exhibit classic symptoms that are associated with the disorder. Duplications of the 15q11-13
1571:
Defects in GABA transmission has often been implicated in epilepsy within animal models and human syndromes. Patients that are diagnosed with
Angelman syndrome and have a deletion of the GABRB3 gene exhibit absence seizures. Reduced expression of the beta-3 subunit is a potential contributor to
1542:
development. A disturbance in GABRB3 expression can be lined to the malformation of nonsyndromic cleft lip with or without cleft palate. Cleft lip and palate have also been observed in children who have inverted duplications encompassing the GABRB3 locus. Knockout of the beta-3 subunit in mice
1529:
Deletion of the GABRB3 gene results in
Angelman syndrome in humans, depending on the parental origin of the deletion. Deletion of the paternal allele of GABRB3 has no known implications with this syndrome, while deletion of the maternal GABRB3 allele results in development of the syndrome.
1451:
and inferior olivary body of the mouse. By adulthood, the level of expression in the cerebral cortex and hippocampus drops below developmental expression levels, but the expression in the cerebellum does not change postnatally. The highest levels of Gabrb3 expression in the mature
2293:
Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (January 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits".
50:
2482:
Tanaka M, Olsen RW, Medina MT, Schwartz E, Alonso ME, Duron RM, Castro-Ortega R, Martinez-Juarez IE, Pascual-Castroviejo I, Machado-Salas J, Silva R, Bailey JN, Bai D, Ochoa A, Jara-Prado A, Pineda G, Macdonald RL, Delgado-Escueta AV (June 2008).
1463:
In humans, the beta-3 subunit, as well as the subunits of its two neighbouring genes (GABRG3 and GABRA5), are bi-allelically expressed within the cerebral cortex, indicating that the gene is not subjected to imprinting within those cells.
1426:
of a human β3 homopentamer was published in 2014. The study of the crystal structure of the human β3 homopentamer revealed unique qualities that are only observed in eukaryotic cysteine-loop receptors. The characterization of the
1516:
of Gabrb3 causes severe neonatal mortality with the cleft palate phenotype present, the survivors experiencing hyperactivity, lack of coordination and suffering with epileptic seizures. These mice also exhibit changes to the
2577:
Saitoh S, Kubota T, Ohta T, Jinno Y, Niikawa N, Sugimoto T, Wagstaff J, Lalande M (February 1992). "Familial
Angelman syndrome caused by imprinted submicroscopic deletion encompassing GABAA receptor beta 3-subunit gene".
1831:
Wagstaff J, Chaillet JR, Lalande M (December 1991). "The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7".
310:
209:
1322:. GABRB3 was the first gene to be mapped to this particular region. It spans approximately 250kb and includes 10 exons within its coding region, as well as two additional alternative first exons that encode for
1472:
Due to the location of GABRB3 in the 15q11-13 imprinting region found in humans, this gene is subject to imprinting depending on the location and the cells developmental state. Imprinting is not present in the
2963:
Buhr A, Bianchi MT, Baur R, Courtet P, Pignay V, Boulenger JP, Gallati S, Hinkle DJ, Macdonald RL, Sigel E (August 2002). "Functional characterization of the new human GABA(A) receptor mutation beta3(R192H)".
1353:
beta-3 subunit sequences, there is a high level of genetic conservation. In mice the Gabrb3 gene is located on chromosome 7 of its genome in a similar gene cluster style with some of the other subunits of the
2337:
Nurmi EL, Dowd M, Tadevosyan-Leyfer O, Haines JL, Folstein SE, Sutcliffe JS (July 2003). "Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13".
2052:"Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder"
1993:
Scapoli L, Martinelli M, Pezzetti F, Carinci F, Bodo M, Tognon M, Carinci P (January 2002). "Linkage disequilibrium between GABRB3 gene and nonsyndromic familial cleft lip with or without cleft palate".
2757:"High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients"
1381:
of the nervous system. The two other genes in the gene cluster both encode for related subunits of the family. During development, when the GABRB3 subunit functions optimally, its role in the GABA
1431:
receptor and subunits helps with the mechanistic determination of mutations within the subunits and what direct effect the mutations may have on the protein and its interactions.
1505:
Mutations in this gene may be associated with the pathogenesis of
Angelman syndrome, nonsyndromic orofacial clefts, epilepsy and autism. The GABRB3 gene has been associated with
1560:
to characteristics found in patients diagnosed with autism spectrum disorder. When studying Gabrb3 deficient mice, significant hypoplasia of the cerebellar vermis was observed.
3046:
Sarto I, Wabnegger L, Dögl E, Sieghart W (September 2002). "Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly".
2687:"gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties"
1931:"Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse"
1881:
Knoll JH, Cheng SD, Lalande M (January 1994). "Allele specificity of DNA replication timing in the
Angelman/Prader-Willi syndrome imprinted chromosomal region".
1781:"A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)"
2722:"A strong promoter element is located between alternative exons of a gene encoding the human gamma-aminobutyric acid-type A receptor beta 3 subunit (GABRB3)"
2652:"Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform"
2099:
Hosie AM, Dunne EL, Harvey RJ, Smart TG (April 2003). "Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity".
3177:
901:
1338:
region that spans the 15q11-13 region. Its sequence is considerably longer than the two other genes found within its gene cluster due to a large 150kb
882:
2246:"15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders"
132:
3275:
1497:. When the MECP2 gene is knocked out, the expression of Gabrb3 is reduced, suggesting a relationship of positive regulation between the two genes.
2883:
Buckley ST, Eckert AL, Dodd PR (September 2000). "Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex".
1779:
Hammer H, Bader BM, Ehnert C, Bundgaard C, Bunch L, Hoestgaard-Jensen K, Schroeder OH, Bastlund JF, Gramowski-Voß A, Jensen AA (August 2015).
1665:
1647:
1385:
receptor allows for proliferation, migration, and differentiation of precursor cells that lead to the proper development of the brain. GABA
3145:
2821:"Evidence for uniparental, paternal expression of the human GABAA receptor subunit genes, using microcell-mediated chromosome transfer"
2615:
Wagstaff J, Knoll JH, Fleming J, Kirkness EF, Martin-Gallardo A, Greenberg F, Graham JM, Menninger J, Ward D, Venter JC (August 1991).
2439:
DeLorey TM, Olsen RW (September 1999). "GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with
Angelman syndrome in man".
1370:
family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for
1521:
within the ear, resulting in poor swimming skills, difficulty in walking on grid floors, and are found to run in circles erratically.
1141:
1439:
The expression of GABRB3 is not constant among all cells or at all stages of development. The distribution of expression of the GABA
1148:
103:, ECA5, gamma-aminobutyric acid type A receptor beta3 subunit, EIEE43, gamma-aminobutyric acid type A receptor subunit beta3, DEE43
3170:
1867:
2617:"Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15"
1393:. The ions bind allosterically to the receptor, a mechanism that is critically dependent on the receptor subunit composition.
3925:
3013:"Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling"
2382:
1543:
results in clefting of the secondary palate. Normal facial characteristics can be restored through the insertion of a Gabrb3
1730:
Cook EH, Courchesne RY, Cox NJ, Lord C, Gonen D, Guter SJ, Lincoln A, Nix K, Haas R, Leventhal BL, Courchesne E (May 1998).
1630:
47:
1609:
3163:
2928:
Buxbaum JD, Silverman JM, Smith CJ, Greenberg DA, Kilifarski M, Reichert J, Cook EH, Fang Y, Song CY, Vitale R (2002).
2398:
Buxbaum JD, Silverman JM, Smith CJ, Greenberg DA, Kilifarski M, Reichert J, Cook EH, Fang Y, Song CY, Vitale R (2002).
1411:
or alter the kinetic properties of the channel. This results in the loss of the inhibitory properties of the receptor.
3586:
3574:
2485:"Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy"
296:
3606:
3483:
1634:
1613:
273:
3155:
3619:
1295:
1266:
of the brain at different points of development and maturity. GABRB3 deficiencies are implicated in many human
946:
195:
170:
927:
112:
1563:
There is an unknown association between autism and the 155CA-2 locus, located within an intron in GABRB3.
1346:
is replicated later than the paternal allele. The reasoning and implications of this pattern are unknown.
2534:"A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity"
1267:
309:
208:
3641:
3598:
302:
201:
3935:
3441:
2142:
99:
3655:
3194:
3115:
3111:
1367:
1120:
1095:
1091:
1087:
1053:
1028:
1024:
1020:
120:
1371:
2227:"Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer"
1547:
into the mouse genome, making the Gabrb3 gene primarily responsible for cleft palate formation.
1407:
within a highly conserved region of the GABRB3 gene can decrease the peak current amplitudes of
1124:
1099:
1083:
1057:
1032:
1016:
625:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
3842:
1586:
3930:
3190:
2790:
Glatt K, Glatt H, Lalande M (April 1997). "Structure and organization of GABRB3 and GABRA5".
1688:
Glatt K, Glatt H, Lalande M (April 1997). "Structure and organization of GABRB3 and GABRA5".
1443:
receptor subunits (GABRB3 included) during development indicates that GABA may function as a
1335:
1275:
1242:, a ligand-gated ion channel. The beta-3 subunit is expressed at different levels within the
184:
140:
2892:
2182:
1942:
1444:
1327:
1227:
2854:
Russek SJ (February 1999). "Evolution of GABA(A) receptor diversity in the human genome".
8:
3855:
2896:
2186:
1946:
3658:
3393:
3202:
3071:
2999:
2916:
2904:
2819:
Meguro M, Mitsuya K, Sui H, Shigenami K, Kugoh H, Nakao M, Oshimura M (November 1997).
2773:
2756:
2633:
2616:
2603:
2509:
2484:
2464:
2351:
2319:
2270:
2245:
2203:
2170:
2124:
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2019:
1906:
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1731:
144:
3059:
3029:
3012:
2867:
2738:
2721:
2703:
2686:
2452:
2307:
1493:
Gabrb3 shows significantly reduced expression postnatally, when mice are deficient in
816:
811:
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796:
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786:
781:
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771:
766:
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3034:
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2908:
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2807:
2778:
2743:
2708:
2673:
2638:
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2514:
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2421:
2378:
2355:
2311:
2275:
2208:
2116:
2081:
2011:
1970:
1965:
1930:
1929:
Nicholls RD, Gottlieb W, Russell LB, Davda M, Horsthemke B, Rinchik EM (March 1993).
1898:
1849:
1845:
1810:
1761:
1705:
1518:
1513:
1423:
1404:
1342:
it carries. A pattern is observed in GABRB3 gene replication, in humans the maternal
1323:
1271:
92:
40:
3003:
2920:
2607:
2468:
2128:
2023:
1910:
3700:
3433:
3055:
3024:
2981:
2973:
2941:
2900:
2863:
2832:
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2768:
2733:
2698:
2663:
2628:
2587:
2545:
2504:
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2411:
2347:
2323:
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2198:
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2003:
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1800:
1792:
1751:
1743:
1697:
1396:
1378:
389:
320:
264:
219:
1414:
The beta-3 subunit has very similar function to the human version of the subunit.
1334:
with distinct signal peptides have been described. This gene is located within an
124:
3185:
1506:
1263:
1243:
1231:
364:
148:
1670:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1652:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3267:
3219:
2500:
1935:
Proceedings of the
National Academy of Sciences of the United States of America
1581:
1460:
and granule cells of the cerebellum, the hippocampus, and the piriform cortex.
1235:
547:
465:
2977:
2067:
2007:
3919:
3745:
3675:
3259:
3211:
3149:
2755:
Sinnett D, Wagstaff J, Glatt K, Woolf E, Kirkness EJ, Lalande M (June 1993).
1457:
1223:
576:
2837:
2820:
1732:"Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers"
525:
403:
3863:
3096:
3067:
3038:
2995:
2955:
2912:
2875:
2803:
2668:
2651:
2559:
2518:
2460:
2425:
2359:
2315:
2279:
2212:
2120:
2085:
2015:
1955:
1814:
1796:
1701:
1401:
1311:
1287:
1259:
382:
161:
2946:
2929:
2846:
2811:
2782:
2747:
2712:
2677:
2642:
2599:
2416:
2399:
2143:"OMIM Entry - * 137192 - GAMMA-AMINOBUTYRIC ACID RECEPTOR, BETA-3; GABRB3"
1974:
1902:
1853:
1765:
1709:
1538:
There is a strong association between GABRB3 expression levels and proper
1188:
1183:
3186:
2986:
2550:
2533:
2261:
1453:
1247:
991:
972:
2194:
1868:"Entrez Gene: GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3"
1350:
1307:
1251:
281:
178:
128:
2244:
Hogart A, Nagarajan RP, Patzel KA, Yasui DH, Lasalle JM (March 2007).
2226:
2050:
DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD (March 2008).
1894:
1477:
brain, having an equal expression from maternal and paternal alleles.
1349:
When comparing the human beta-3 subunit's genetic sequence with other
69:
1544:
1291:
846:
348:
335:
247:
234:
136:
2112:
1747:
1448:
1279:
1255:
1172:
2340:
Journal of the
American Academy of Child and Adolescent Psychiatry
1310:
15, within the q12 region in the human genome. It is located in a
3790:
3785:
3534:
3136:
3126:
1331:
1204:
958:
913:
831:
827:
2336:
1992:
116:
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3765:
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3755:
3554:
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3544:
3539:
3529:
3524:
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3514:
3509:
3504:
3499:
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3410:
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3307:
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3283:
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1539:
1408:
1343:
1339:
1319:
1315:
1283:
1215:
1156:
868:
556:
2927:
2397:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3823:
3815:
3750:
3725:
3720:
3715:
3710:
3705:
3694:
3689:
3684:
3679:
3564:
3559:
3465:
3457:
3449:
3386:
3381:
3376:
3371:
3247:
3242:
3237:
3232:
3227:
2049:
1494:
1474:
3121:
Overview of all the structural information available in the
2614:
2532:
Urak L, Feucht M, Fathi N, Hornik K, Fuchs K (August 2006).
1928:
3473:
3082:
1219:
1211:
3045:
2243:
1778:
3135:(Gamma-aminobutyric acid receptor subunit beta-3) at the
2818:
2754:
2684:
2481:
1390:
372:
2377:. New Jersey: John Wiley & Sons, Inc. p. 363.
1830:
3083:
Słopień A, Rajewski A, Budny B, Czerski P (2003). "".
2962:
2930:"Association between a GABRB3 polymorphism and autism"
2685:
Tögel M, Mossier B, Fuchs K, Sieghart W (April 1994).
2400:"Association between a GABRB3 polymorphism and autism"
1566:
2576:
2531:
2098:
1729:
1214:. It is located within the 15q12 region in the human
537:
3854:
3017:Biochimica et Biophysica Acta (BBA) - Biomembranes
1626:
1624:
1622:
1605:
1603:
1601:
1533:
2882:
2789:
1880:
1687:
319:
218:
3917:
1924:
1922:
1920:
2045:
2043:
2041:
2039:
2037:
2035:
2033:
1988:
1986:
1984:
1826:
1824:
1619:
1598:
1201:Gamma-aminobutyric acid receptor subunit beta-3
717:negative regulation of neuron apoptotic process
605:extracellular ligand-gated ion channel activity
16:Protein-coding gene in the species Homo sapiens
2719:
2168:
2164:
2162:
1631:GRCm38: Ensembl release 89: ENSMUSG00000033676
1306:The GABRB3 gene is located on the long arm of
3171:
2171:"Crystal structure of a human GABAA receptor"
1917:
2438:
2330:
2286:
2030:
1981:
1821:
1683:
1681:
1679:
2159:
1725:
1723:
1721:
1719:
1610:GRCh38: Ensembl release 89: ENSG00000166206
1550:
3178:
3164:
3146:United States National Library of Medicine
2885:Annals of the New York Academy of Sciences
2649:
3114:at the U.S. National Library of Medicine
3028:
2985:
2945:
2836:
2772:
2737:
2702:
2667:
2632:
2549:
2508:
2415:
2269:
2202:
2075:
1964:
1954:
1804:
1755:
1676:
792:gamma-aminobutyric acid signaling pathway
620:transmembrane signaling receptor activity
3144:This article incorporates text from the
2720:Kirkness EF, Fraser CM (February 1993).
1716:
1500:
610:GABA-gated chloride ion channel activity
3010:
2372:
1389:receptor function is inhibited by zinc
1218:and spans 250kb. This gene includes 10
3918:
2853:
2169:Miller PS, Aricescu AR (August 2014).
1860:
1467:
737:regulation of neuron apoptotic process
3159:
661:integral component of plasma membrane
324:
285:
280:
223:
182:
177:
2296:Molecular and Cellular Neurosciences
1524:
1509:skills accompanying such disorders.
2726:The Journal of Biological Chemistry
2691:The Journal of Biological Chemistry
2650:Russek SJ, Farb DH (October 1994).
1567:Epilepsy/Childhood absence epilepsy
777:negative regulation of neuron death
757:inner ear receptor cell development
13:
2905:10.1111/j.1749-6632.2000.tb05183.x
2761:American Journal of Human Genetics
2621:American Journal of Human Genetics
2569:
2489:American Journal of Human Genetics
2352:10.1097/01.CHI.0000046868.56865.0F
1736:American Journal of Human Genetics
14:
3947:
3105:
1278:, nonsyndromic orofacial clefts,
1207:that in humans is encoded by the
732:inhibitory postsynaptic potential
442:lateral nuclear group of thalamus
807:regulation of membrane potential
787:chloride transmembrane transport
546:
308:
301:
295:
272:
207:
200:
194:
169:
2525:
2475:
2432:
2391:
2366:
2237:
2219:
2135:
2092:
1874:
1534:Nonsyndromic Orofacial Clefting
1366:GABRB3 encodes a member of the
1772:
1658:
1640:
1296:positive allosteric modulation
802:chemical synaptic transmission
782:cellular response to histamine
641:integral component of membrane
557:More reference expression data
526:More reference expression data
1:
3060:10.1016/S0028-3908(02)00160-0
3030:10.1016/S0005-2736(02)00512-6
2868:10.1016/S0378-1119(98)00594-0
2739:10.1016/S0021-9258(18)53626-7
2704:10.1016/S0021-9258(18)99974-6
2453:10.1016/s0920-1211(99)00046-7
2375:Fundamental Molecular Biology
2373:Allison, Lizabeth A. (2012).
2308:10.1016/S1044-7431(02)00017-9
1592:
1480:
1434:
1330:transcript variants encoding
293:
192:
3926:Genes on human chromosome 15
3011:Trudell J (September 2002).
2592:10.1016/0140-6736(92)91686-3
1846:10.1016/0888-7543(91)90034-C
1572:childhood absence epilepsy.
1417:
1294:are mediated through GABBR3
1268:neurodevelopmental disorders
1234:, all being subunits in the
686:cytoplasmic vesicle membrane
7:
1575:
1485:Phosphorylation of the GABA
1361:
817:inhibitory synapse assembly
797:ion transmembrane transport
10:
3952:
2501:10.1016/j.ajhg.2008.04.020
2056:Behavioural Brain Research
1230:, the gene codes for many
3841:
3801:
3738:Voltage- and ligand-gated
3736:
3666:
3654:
3632:
3482:
3432:
3258:
3210:
3201:
3195:ligand-gated ion channels
2978:10.1007/s00439-002-0766-7
2233:. RCSB. January 28, 2014.
2068:10.1016/j.bbr.2007.09.009
2008:10.1007/s00439-001-0639-5
1666:"Mouse PubMed Reference:"
1648:"Human PubMed Reference:"
1187:
1182:
1178:
1171:
1155:
1136:
1117:
1113:
1080:
1076:
1069:
1050:
1046:
1013:
1009:
1002:
989:
985:
970:
966:
957:
944:
940:
925:
921:
912:
899:
895:
880:
876:
867:
852:
845:
841:
825:
727:roof of mouth development
615:identical protein binding
600:chloride channel activity
575:
571:
554:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
3116:Medical Subject Headings
2825:Human Molecular Genetics
2538:Human Molecular Genetics
2250:Human Molecular Genetics
1551:Autism Spectrum Disorder
1368:ligand-gated ion channel
1314:, with two other genes,
1142:Chr 15: 26.54 – 26.94 Mb
666:chloride channel complex
590:GABA-A receptor activity
492:anterior amygdaloid area
3484:Nicotinic acetylcholine
1377:, the major inhibitory
1301:
1149:Chr 7: 57.07 – 57.48 Mb
676:GABA-A receptor complex
2804:10.1006/geno.1997.4639
2669:10.1006/geno.1994.1539
1956:10.1073/pnas.90.5.2050
1797:10.1124/mol.115.099291
1785:Molecular Pharmacology
1702:10.1006/geno.1997.4639
1587:Heritability of autism
1270:and syndromes such as
812:nervous system process
480:lateral septal nucleus
434:superior frontal gyrus
3191:cell surface receptor
3112:GABRB3+protein,+human
2947:10.1038/sj.mp.4001011
2838:10.1093/hmg/6.12.2127
2417:10.1038/sj.mp.4001011
1501:Clinical significance
1328:Alternatively spliced
1276:Prader-Willi syndrome
646:postsynaptic membrane
414:middle temporal gyrus
185:Chromosome 15 (human)
3856:Purinergic receptors
2934:Molecular Psychiatry
2404:Molecular Psychiatry
1228:alternative splicing
595:ion channel activity
484:ventromedial nucleus
326:7 B5|7 33.53 cM
287:Chromosome 7 (mouse)
62:List of PDB id codes
35:Available structures
2897:2000NYASA.914...58B
2697:(17): 12993–12998.
2195:10.1038/nature13293
2187:2014Natur.512..270M
2101:Nature Neuroscience
1947:1993PNAS...90.2050N
1468:Imprinting Patterns
1445:neurotrophic factor
772:signal transduction
722:cochlea development
691:cytoplasmic vesicle
446:islet of Langerhans
3624:β1δε - Muscle type
3203:Cys-loop receptors
3148:, which is in the
3085:Psychiatria Polska
2551:10.1093/hmg/ddl174
2262:10.1093/hmg/ddm014
1405:missense mutations
1375:-aminobutyric acid
1324:signaling peptides
947:ENSMUSG00000033676
762:chloride transport
742:neuron development
710:Biological process
701:GABA-ergic synapse
634:Cellular component
583:Molecular function
476:olfactory tubercle
149:GABRB3 - orthologs
3913:
3912:
3909:
3908:
3837:
3836:
3668:Ligand-gated only
3650:
3649:
3048:Neuropharmacology
2831:(12): 2127–2133.
2586:(8789): 366–367.
2544:(16): 2533–2541.
2441:Epilepsy Research
2384:978-1-118-05981-4
2231:Protein Data Bank
2181:(7514): 270–275.
1895:10.1038/ng0194-41
1525:Angelman syndrome
1519:vestibular system
1514:knockout mutation
1424:crystal structure
1286:. The effects of
1272:Angelman syndrome
1198:
1197:
1194:
1193:
1167:
1166:
1132:
1131:
1107:
1106:
1065:
1064:
1040:
1039:
998:
997:
979:
978:
953:
952:
934:
933:
908:
907:
889:
888:
837:
836:
696:neuron projection
567:
566:
563:
562:
532:
531:
519:
518:
488:nucleus accumbens
457:
456:
450:prefrontal cortex
438:postcentral gyrus
422:entorhinal cortex
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
3943:
3936:Causes of autism
3852:
3851:
3664:
3663:
3208:
3207:
3180:
3173:
3166:
3157:
3156:
3100:
3079:
3042:
3032:
3007:
2989:
2959:
2949:
2924:
2879:
2850:
2840:
2815:
2786:
2776:
2767:(6): 1216–1229.
2751:
2741:
2732:(6): 4420–4428.
2716:
2706:
2681:
2671:
2646:
2636:
2611:
2564:
2563:
2553:
2529:
2523:
2522:
2512:
2495:(6): 1249–1261.
2479:
2473:
2472:
2447:(2–3): 123–132.
2436:
2430:
2429:
2419:
2395:
2389:
2388:
2370:
2364:
2363:
2334:
2328:
2327:
2290:
2284:
2283:
2273:
2241:
2235:
2234:
2223:
2217:
2216:
2206:
2166:
2157:
2156:
2154:
2153:
2139:
2133:
2132:
2096:
2090:
2089:
2079:
2047:
2028:
2027:
1990:
1979:
1978:
1968:
1958:
1941:(5): 2050–2054.
1926:
1915:
1914:
1878:
1872:
1871:
1864:
1858:
1857:
1840:(4): 1071–1078.
1828:
1819:
1818:
1808:
1776:
1770:
1769:
1759:
1742:(5): 1077–1083.
1727:
1714:
1713:
1685:
1674:
1673:
1662:
1656:
1655:
1644:
1638:
1628:
1617:
1607:
1379:neurotransmitter
1232:protein isoforms
1180:
1179:
1151:
1144:
1127:
1111:
1110:
1102:
1074:
1073:
1070:RefSeq (protein)
1060:
1044:
1043:
1035:
1007:
1006:
983:
982:
964:
963:
938:
937:
919:
918:
893:
892:
874:
873:
843:
842:
573:
572:
559:
550:
543:
542:
528:
468:
466:Top expressed in
461:
460:
426:endothelial cell
418:Brodmann area 23
406:
404:Top expressed in
399:
398:
378:
377:
361:
360:
351:
338:
327:
312:
305:
299:
288:
276:
260:
259:
250:
237:
226:
211:
204:
198:
187:
173:
157:
156:
151:
102:
95:
72:
59:
58:
53:
32:
31:
19:
18:
3951:
3950:
3946:
3945:
3944:
3942:
3941:
3940:
3916:
3915:
3914:
3905:
3833:
3827:
3819:
3797:
3732:
3646:
3628:
3623:
3615:- Ganglion type
3614:
3610:
3602:
3594:
3590:
3582:
3578:
3478:
3469:
3461:
3453:
3445:
3428:
3422:
3414:
3406:
3397:
3367:
3359:
3351:
3343:
3335:
3327:
3319:
3311:
3303:
3295:
3287:
3279:
3271:
3254:
3223:
3197:
3184:
3108:
3103:
2572:
2570:Further reading
2567:
2530:
2526:
2480:
2476:
2437:
2433:
2396:
2392:
2385:
2371:
2367:
2335:
2331:
2291:
2287:
2242:
2238:
2225:
2224:
2220:
2167:
2160:
2151:
2149:
2141:
2140:
2136:
2097:
2093:
2048:
2031:
1991:
1982:
1927:
1918:
1883:Nature Genetics
1879:
1875:
1866:
1865:
1861:
1829:
1822:
1777:
1773:
1728:
1717:
1686:
1677:
1664:
1663:
1659:
1646:
1645:
1641:
1629:
1620:
1608:
1599:
1595:
1578:
1569:
1553:
1536:
1527:
1503:
1488:
1483:
1470:
1442:
1437:
1430:
1420:
1388:
1384:
1364:
1357:
1304:
1264:piriform cortex
1244:cerebral cortex
1239:
1189:View/Edit Mouse
1184:View/Edit Human
1147:
1140:
1137:Location (UCSC)
1123:
1119:
1098:
1094:
1090:
1086:
1082:
1056:
1052:
1031:
1027:
1023:
1019:
1015:
928:ENSG00000166206
821:
705:
681:plasma membrane
629:
555:
524:
515:
512:globus pallidus
510:
506:
502:
500:mammillary body
498:
496:arcuate nucleus
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
3949:
3939:
3938:
3933:
3928:
3911:
3910:
3907:
3906:
3904:
3903:
3902:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3860:
3858:
3849:
3847:gated channels
3839:
3838:
3835:
3834:
3832:
3831:
3830:
3829:
3825:
3821:
3817:
3807:
3805:
3799:
3798:
3796:
3795:
3794:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3742:
3740:
3734:
3733:
3731:
3730:
3729:
3728:
3723:
3718:
3713:
3708:
3698:
3692:
3687:
3682:
3672:
3670:
3661:
3652:
3651:
3648:
3647:
3645:
3644:
3642:Zinc-activated
3638:
3636:
3630:
3629:
3627:
3626:
3621:
3617:
3612:
3608:
3604:
3600:
3596:
3592:
3588:
3584:
3580:
3576:
3568:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3488:
3486:
3480:
3479:
3477:
3476:
3471:
3467:
3463:
3459:
3455:
3451:
3447:
3443:
3438:
3436:
3430:
3429:
3427:
3426:
3425:
3424:
3420:
3416:
3412:
3408:
3404:
3395:
3391:
3390:
3389:
3384:
3379:
3374:
3369:
3365:
3361:
3357:
3353:
3349:
3345:
3341:
3337:
3333:
3329:
3325:
3321:
3317:
3313:
3309:
3305:
3301:
3297:
3293:
3289:
3285:
3281:
3277:
3269:
3264:
3262:
3256:
3255:
3253:
3252:
3251:
3250:
3245:
3240:
3235:
3230:
3221:
3216:
3214:
3212:5-HT/serotonin
3205:
3199:
3198:
3183:
3182:
3175:
3168:
3160:
3141:
3140:
3119:
3107:
3106:External links
3104:
3102:
3101:
3091:(5): 779–791.
3080:
3054:(4): 482–491.
3043:
3008:
2972:(2): 154–160.
2966:Human Genetics
2960:
2940:(3): 311–316.
2925:
2880:
2862:(2): 213–222.
2851:
2816:
2787:
2752:
2717:
2682:
2662:(3): 528–533.
2647:
2627:(2): 330–337.
2612:
2573:
2571:
2568:
2566:
2565:
2524:
2474:
2431:
2410:(3): 311–316.
2390:
2383:
2365:
2346:(7): 856–863.
2329:
2285:
2256:(6): 691–703.
2236:
2218:
2158:
2134:
2113:10.1038/nn1030
2107:(4): 362–369.
2091:
2062:(2): 207–220.
2029:
1996:Human Genetics
1980:
1916:
1873:
1859:
1820:
1791:(2): 401–420.
1771:
1748:10.1086/301832
1715:
1675:
1657:
1639:
1618:
1596:
1594:
1591:
1590:
1589:
1584:
1582:GABAA receptor
1577:
1574:
1568:
1565:
1552:
1549:
1535:
1532:
1526:
1523:
1502:
1499:
1486:
1482:
1479:
1469:
1466:
1440:
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1428:
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1416:
1386:
1382:
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1303:
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1192:
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1186:
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1168:
1165:
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1134:
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1129:
1115:
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1108:
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1078:
1077:
1071:
1067:
1066:
1063:
1062:
1048:
1047:
1041:
1038:
1037:
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1010:
1004:
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996:
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987:
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729:
724:
719:
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561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
508:olfactory bulb
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
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269:
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256:
255:
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109:
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96:
88:
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82:
79:
78:
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74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
3948:
3937:
3934:
3932:
3929:
3927:
3924:
3923:
3921:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3866:
3865:
3862:
3861:
3859:
3857:
3853:
3850:
3848:
3844:
3840:
3828:
3822:
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3813:
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3809:
3808:
3806:
3804:
3800:
3792:
3789:
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3784:
3782:
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3777:
3774:
3772:
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3762:
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3702:
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3489:
3487:
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3456:
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3448:
3446:
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3439:
3437:
3435:
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3401:
3400:
3399:
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3370:
3368:
3362:
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3354:
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3320:
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3312:
3306:
3304:
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3272:
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3265:
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3257:
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3246:
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3239:
3236:
3234:
3231:
3229:
3226:
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3218:
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3215:
3213:
3209:
3206:
3204:
3200:
3196:
3192:
3188:
3181:
3176:
3174:
3169:
3167:
3162:
3161:
3158:
3154:
3153:
3151:
3150:public domain
3147:
3138:
3134:
3133:
3128:
3124:
3120:
3117:
3113:
3110:
3109:
3098:
3094:
3090:
3086:
3081:
3077:
3073:
3069:
3065:
3061:
3057:
3053:
3049:
3044:
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3036:
3031:
3026:
3022:
3018:
3014:
3009:
3005:
3001:
2997:
2993:
2988:
2987:2027.42/42268
2983:
2979:
2975:
2971:
2967:
2961:
2957:
2953:
2948:
2943:
2939:
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2172:
2165:
2163:
2148:
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2110:
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2095:
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2069:
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2057:
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2046:
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2040:
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2036:
2034:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
1997:
1989:
1987:
1985:
1976:
1972:
1967:
1962:
1957:
1952:
1948:
1944:
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1936:
1932:
1925:
1923:
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1908:
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1900:
1896:
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1807:
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1597:
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1579:
1573:
1564:
1561:
1557:
1548:
1546:
1541:
1531:
1522:
1520:
1515:
1512:In mice, the
1510:
1508:
1498:
1496:
1491:
1478:
1476:
1465:
1461:
1459:
1456:occur in the
1455:
1450:
1446:
1432:
1425:
1415:
1412:
1410:
1406:
1403:
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1399:
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1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1233:
1229:
1225:
1224:coding region
1221:
1217:
1213:
1210:
1206:
1202:
1190:
1185:
1181:
1177:
1174:
1170:
1163:
1161:
1158:
1154:
1150:
1146:
1143:
1139:
1135:
1128:
1126:
1122:
1116:
1112:
1109:
1103:
1101:
1097:
1093:
1089:
1085:
1079:
1075:
1072:
1068:
1061:
1059:
1055:
1049:
1045:
1042:
1036:
1034:
1030:
1026:
1022:
1018:
1012:
1008:
1005:
1003:RefSeq (mRNA)
1001:
994:
993:
988:
984:
981:
975:
974:
969:
965:
962:
960:
956:
949:
948:
943:
939:
936:
930:
929:
924:
920:
917:
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911:
904:
903:
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894:
891:
885:
884:
879:
875:
872:
870:
866:
863:
860:
858:
855:
851:
848:
844:
840:
833:
829:
824:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
752:ion transport
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
714:
712:
709:
708:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
671:cell junction
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
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633:
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623:
621:
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608:
606:
603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
430:parietal lobe
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
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370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3931:Ion channels
3846:
3810:
3802:
3737:
3667:
3633:
3571:
3491:
3339:
3143:
3142:
3130:
3088:
3084:
3051:
3047:
3023:(1): 91–96.
3020:
3016:
2969:
2965:
2937:
2933:
2891:(1): 58–64.
2888:
2884:
2859:
2855:
2828:
2824:
2798:(1): 63–69.
2795:
2791:
2764:
2760:
2729:
2725:
2694:
2690:
2659:
2655:
2624:
2620:
2583:
2579:
2541:
2537:
2527:
2492:
2488:
2477:
2444:
2440:
2434:
2407:
2403:
2393:
2374:
2368:
2343:
2339:
2332:
2302:(1): 87–97.
2299:
2295:
2288:
2253:
2249:
2239:
2230:
2221:
2178:
2174:
2150:. Retrieved
2146:
2137:
2104:
2100:
2094:
2059:
2055:
2002:(1): 15–20.
1999:
1995:
1938:
1934:
1889:(1): 41–46.
1886:
1882:
1876:
1862:
1837:
1833:
1788:
1784:
1774:
1739:
1735:
1696:(1): 63–69.
1693:
1689:
1669:
1660:
1651:
1642:
1570:
1562:
1558:
1554:
1537:
1528:
1511:
1504:
1492:
1484:
1471:
1462:
1438:
1421:
1413:
1402:heterozygous
1397:
1395:
1372:
1365:
1348:
1312:gene cluster
1305:
1288:methaqualone
1260:olivary body
1208:
1200:
1199:
1121:NP_001033790
1118:
1096:NP_001265560
1092:NP_001178250
1088:NP_001178249
1081:
1054:NM_001038701
1051:
1029:NM_001278631
1025:NM_001191321
1021:NM_001191320
1014:
990:
971:
945:
926:
900:
881:
861:
856:
388:
381:
108:External IDs
67:
3187:Ion channel
1454:mouse brain
1248:hippocampus
1222:within its
767:innervation
347:57,478,550
334:57,069,440
246:26,939,539
233:26,543,546
86:Identifiers
3920:Categories
3659:glutamates
3656:Ionotropic
3572:pentamers:
2152:2017-11-30
1637:, May 2017
1616:, May 2017
1593:References
1481:Regulation
1435:Expression
1358:receptor.
1351:vertebrate
1336:imprinting
1308:chromosome
1252:cerebellum
392:(ortholog)
129:HomoloGene
3492:monomers:
3076:140209788
1545:transgene
1418:Structure
1292:etomidate
1226:. Due to
1125:NP_032097
1100:NP_068712
1084:NP_000805
1058:NM_008071
1033:NM_021912
1017:NM_000814
847:Orthologs
504:subiculum
137:GeneCards
3803:‘Orphan’
3097:12491987
3068:12367595
3039:12225856
3004:10982155
2996:12189488
2956:11920158
2921:13569188
2913:11085308
2876:10023064
2792:Genomics
2656:Genomics
2608:40634548
2560:16835263
2519:18514161
2469:13656488
2461:10515160
2426:11920158
2360:12819446
2316:12595241
2280:17339270
2213:24909990
2147:omim.org
2129:24096465
2121:12640458
2086:17983671
2024:23459069
2016:11810291
1911:35832564
1834:Genomics
1815:26056160
1690:Genomics
1633:–
1612:–
1576:See also
1458:Purkinje
1449:thalamus
1362:Function
1332:isoforms
1280:epilepsy
1256:thalamus
1240:receptor
1173:Wikidata
826:Sources:
651:membrane
3701:Kainate
3434:Glycine
3137:PDBe-KB
3127:UniProt
2893:Bibcode
2847:9328477
2812:9126483
2783:8389098
2774:1682269
2748:8382702
2713:8175718
2678:7851879
2643:1714232
2634:1683305
2600:1346439
2510:2427288
2324:6172436
2271:1934608
2204:4167603
2183:Bibcode
2077:2684890
1975:8095339
1943:Bibcode
1903:8136833
1854:1664410
1806:4518083
1766:9545402
1757:1377089
1710:9126483
1635:Ensembl
1614:Ensembl
1409:neurons
1398:De novo
1205:protein
959:UniProt
914:Ensembl
853:Species
832:QuickGO
747:hearing
656:synapse
367:pattern
93:Aliases
3132:P28472
3118:(MeSH)
3095:
3074:
3066:
3037:
3002:
2994:
2954:
2919:
2911:
2874:
2845:
2810:
2781:
2771:
2746:
2711:
2676:
2641:
2631:
2606:
2598:
2580:Lancet
2558:
2517:
2507:
2467:
2459:
2424:
2381:
2358:
2322:
2314:
2278:
2268:
2211:
2201:
2175:Nature
2127:
2119:
2084:
2074:
2022:
2014:
1973:
1963:
1909:
1901:
1852:
1813:
1803:
1764:
1754:
1708:
1540:palate
1507:savant
1344:allele
1340:intron
1320:GABRA5
1316:GABRG3
1284:autism
1216:genome
1209:GABRB3
1159:search
1157:PubMed
992:P63080
973:P28472
869:Entrez
538:BioGPS
141:GABRB3
117:137192
100:GABRB3
22:GABRB3
3072:S2CID
3000:S2CID
2917:S2CID
2604:S2CID
2465:S2CID
2320:S2CID
2125:S2CID
2020:S2CID
1966:46018
1907:S2CID
1495:MECP2
1475:mouse
1373:gamma
1220:exons
1203:is a
902:14402
862:Mouse
857:Human
828:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
225:15q12
162:Human
125:95621
3811:GluD
3746:NMDA
3676:AMPA
3634:Zinc
3620:(α1)
3611:(β4)
3607:(α1)
3599:(α7)
3591:(β2)
3587:(α4)
3579:(β4)
3575:(α3)
3394:GABA
3268:GABA
3260:GABA
3220:5-HT
3125:for
3093:PMID
3064:PMID
3035:PMID
3021:1565
2992:PMID
2952:PMID
2909:PMID
2872:PMID
2856:Gene
2843:PMID
2808:PMID
2779:PMID
2744:PMID
2709:PMID
2674:PMID
2639:PMID
2596:PMID
2556:PMID
2515:PMID
2457:PMID
2422:PMID
2379:ISBN
2356:PMID
2312:PMID
2276:PMID
2209:PMID
2117:PMID
2082:PMID
2012:PMID
1971:PMID
1899:PMID
1850:PMID
1811:PMID
1762:PMID
1706:PMID
1427:GABA
1422:The
1391:ions
1354:GABA
1318:and
1302:Gene
1290:and
1282:and
1262:and
1236:GABA
1212:gene
883:2562
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:4COF
51:RCSB
48:PDBe
3864:P2X
3843:ATP
3791:L1B
3786:L1A
3535:α10
3123:PDB
3056:doi
3025:doi
2982:hdl
2974:doi
2970:111
2942:doi
2901:doi
2889:914
2864:doi
2860:227
2833:doi
2800:doi
2769:PMC
2734:doi
2730:268
2699:doi
2695:269
2664:doi
2629:PMC
2588:doi
2584:339
2546:doi
2505:PMC
2497:doi
2449:doi
2412:doi
2348:doi
2304:doi
2266:PMC
2258:doi
2199:PMC
2191:doi
2179:512
2109:doi
2072:PMC
2064:doi
2060:187
2004:doi
2000:110
1961:PMC
1951:doi
1891:doi
1842:doi
1801:PMC
1793:doi
1752:PMC
1744:doi
1698:doi
343:End
242:End
145:OMA
133:633
121:MGI
41:PDB
3922::
3781:3B
3776:3A
3771:2D
3766:2C
3761:2B
3756:2A
3555:β4
3550:β3
3545:β2
3540:β1
3530:α9
3525:α7
3520:α6
3515:α5
3510:α4
3505:α3
3500:α2
3495:α1
3398:-ρ
3193::
3189:,
3129::
3089:36
3087:.
3070:.
3062:.
3052:43
3050:.
3033:.
3019:.
3015:.
2998:.
2990:.
2980:.
2968:.
2950:.
2936:.
2932:.
2915:.
2907:.
2899:.
2887:.
2870:.
2858:.
2841:.
2827:.
2823:.
2806:.
2796:41
2794:.
2777:.
2765:52
2763:.
2759:.
2742:.
2728:.
2724:.
2707:.
2693:.
2689:.
2672:.
2660:23
2658:.
2654:.
2637:.
2625:49
2623:.
2619:.
2602:.
2594:.
2582:.
2554:.
2542:15
2540:.
2536:.
2513:.
2503:.
2493:82
2491:.
2487:.
2463:.
2455:.
2445:36
2443:.
2420:.
2406:.
2402:.
2354:.
2344:42
2342:.
2318:.
2310:.
2300:22
2298:.
2274:.
2264:.
2254:16
2252:.
2248:.
2229:.
2207:.
2197:.
2189:.
2177:.
2173:.
2161:^
2145:.
2123:.
2115:.
2103:.
2080:.
2070:.
2058:.
2054:.
2032:^
2018:.
2010:.
1998:.
1983:^
1969:.
1959:.
1949:.
1939:90
1937:.
1933:.
1919:^
1905:.
1897:.
1885:.
1848:.
1838:11
1836:.
1823:^
1809:.
1799:.
1789:88
1787:.
1783:.
1760:.
1750:.
1740:62
1738:.
1734:.
1718:^
1704:.
1694:41
1692:.
1678:^
1668:.
1650:.
1621:^
1600:^
1326:.
1298:.
1274:,
1258:,
1254:,
1250:,
1246:,
830:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
3899:7
3894:6
3889:5
3884:4
3879:3
3874:2
3869:1
3845:-
3826:2
3824:δ
3818:1
3816:δ
3751:1
3726:5
3721:4
3716:3
3711:2
3706:1
3697:)
3695:4
3690:3
3685:2
3680:1
3678:(
3622:2
3613:3
3609:2
3601:5
3593:3
3589:2
3581:3
3577:2
3565:ε
3560:δ
3474:β
3468:4
3466:α
3460:3
3458:α
3452:2
3450:α
3444:1
3442:α
3421:3
3419:ρ
3413:2
3411:ρ
3405:1
3403:ρ
3396:A
3387:θ
3382:π
3377:ε
3372:δ
3366:3
3364:γ
3358:2
3356:γ
3350:1
3348:γ
3342:3
3340:β
3334:2
3332:β
3326:1
3324:β
3318:6
3316:α
3310:5
3308:α
3302:4
3300:α
3294:3
3292:α
3286:2
3284:α
3278:1
3276:α
3270:A
3248:E
3243:D
3238:C
3233:B
3228:A
3222:3
3179:e
3172:t
3165:v
3152:.
3139:.
3099:.
3078:.
3058::
3041:.
3027::
3006:.
2984::
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