329:
306:
228:
203:
2537:
2567:
2552:
587:
580:
335:
234:
40:
1425:
Owren initially felt that factor V (labile factor or proaccelerin) activated another factor, which he named VI. VI was the factor that accelerated the conversion from prothrombin to thrombin. It was later discovered that factor V was "converted" (activated) by thrombin itself, and later still that
1407:
leading to prothrombin deficiency. However, neither were the case, and Owren demonstrated this by correcting the abnormality with plasma from which prothrombin had been removed. Using Mary's serum as index, he found that the "missing" factor, which he labeled V (IâIV having been used in
Morawitz'
1309:
There exists a bleeding tendency associated with the genetic upâregulation of FVâshort, a minor splicing isoform of FV. This abnormal bleeding tendency occurs in east Texas bleeding disorder, Amsterdam bleeding disorder, and a third and more extreme example described in 2021 by Karen L. Zimowski
1235:
Activation of factor V to factor Va is done by cleavage and release of the B domain, after which the protein no longer assists in activating protein C. The protein is now divided to a heavy chain, consisting of the A1-A2 domains, and a light chain, consisting of the A3-C1-C2 domains. Both form
1344:
at amino acid position 506 (R506Q). All prothrombotic factor V mutations (factor V Leiden, factor V Cambridge, factor V Hong Kong) make it resistant to cleavage by activated protein C ("APC resistance"). It therefore remains active and increases the rate of thrombin generation.
66:
1421:
The possibility of an extra coagulation factor was initially resisted on methodological grounds by Drs Armand Quick and Walter
Seegers, both world authorities in coagulation. Confirmatory studies from other groups led to their final approval several years later.
1676:
Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P (November 1999). "Crystal structures of the membrane-binding C2 domain of human coagulation factor V".
1248:, which produce platelets and platelet-derived factor V, and hepatocytes, which produce plasma-derived factor V. The molecule circulates in plasma as a single-chain molecule with a plasma half-life of 12â36 hours.
342:
241:
1997:
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH (May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C".
1259:. On activation, factor V is spliced in two chains (heavy and light chain with molecular masses of 110000 and 73000, respectively) which are noncovalently bound to each other by
2536:
2566:
2257:
850:
831:
2387:
Andreassi MG, Botto N, Maffei S (2006). "Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening".
1412:, and while Owren published his results in Norway in 1944, he could not publish them internationally until the war was over. They appeared finally in
1286:, thrombin acts to decrease clotting by activating protein C; therefore, the concentration and action of protein C are important determinants in the
164:
2607:
2551:
1533:
1515:
1373:
2999:
1050:
1057:
1179:. The gene spans 70 kb, consists of 25 exons, and the resulting protein has a relative molecular mass of approximately 330kDa.
2516:
1498:
1198:, and form a triangular as in that protein. A copper ion is bound in the A1-A3 interface, and A3 interacts with the plasma.
3079:
2868:
2092:"Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C"
63:
2174:
Segers K, DahlbÀck B, Nicolaes GA (September 2007). "Coagulation factor V and thrombophilia: background and mechanisms".
1903:
Owren PA (April 1947). "Parahaemophilia; haemorrhagic diathesis due to absence of a previously unknown clotting factor".
1477:
1387:
physician, during his investigations into the bleeding tendency of a lady called Mary (1914â2002). She had suffered from
2600:
2994:
2916:
2911:
3045:
328:
2873:
2709:
1502:
1481:
305:
2699:
2296:
1302:(termed parahemophilia or Owren parahemophilia), the incidence of which is about 1:1,000,000. It inherits in an
2649:
895:
2949:
2593:
876:
2901:
2754:
227:
202:
144:
3084:
1450:
1637:"The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V"
1298:
Various hereditary disorders of factor V are known. Deficiency is associated with a rare mild form of
2989:
2509:
1585:"Structural investigation of the A domains of human blood coagulation factor V by molecular modeling"
1236:
non-covalently a complex in a calcium-dependent manner. This complex is the pro-coagulant factor Va.
341:
240:
131:
1139:. In contrast to most other coagulation factors, it is not enzymatically active but functions as a
334:
233:
152:
2258:"Novel factor V C2-domain mutation (R2074H) in two families with factor V deficiency and bleeding"
1218:
1176:
1140:
1938:
Jenny RJ, Pittman DD, Toole JJ, Kriz RW, Aldape RA, Hewick RM, Kaufman RJ, Mann KG (July 1987).
1033:
1012:
986:
965:
2815:
2811:
2779:
2545:: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY
2930:
2674:
2643:
2633:
1404:
2502:
2007:
1951:
1686:
216:
2971:
2468:
2424:
Du X (May 2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex".
8:
2981:
2958:
2939:
2921:
2616:
2136:
1580:
1303:
1172:
2575:: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM
2011:
1955:
1690:
1353:
Until the discovery of factor V, coagulation was regarded as a product of four factors:
172:
2624:
2449:
2412:
2375:
2338:
2288:
2199:
2157:
2140:
2031:
1829:
1804:
1710:
1609:
1584:
1260:
1191:
176:
2108:
2091:
1974:
1939:
1916:
1408:
model), had particular characteristics. Most investigations were performed during the
1395:(excessive menstrual blood loss) for most her life, and was found to have a prolonged
765:
760:
755:
750:
745:
740:
735:
730:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
638:
633:
628:
3009:
2966:
2483:
2474:
2441:
2404:
2367:
2330:
2280:
2244:
2239:
2212:
2191:
2162:
2113:
2072:
2023:
1979:
1920:
1885:
1880:
1863:
1834:
1785:
1780:
1763:
1737:
1702:
1658:
1614:
1321:
1287:
1271:(FXa) enzyme requires calcium and activated factor V (FVa) to convert prothrombin to
124:
56:
2453:
2416:
2379:
2203:
3022:
3017:
2433:
2396:
2359:
2342:
2320:
2292:
2272:
2234:
2224:
2183:
2152:
2103:
2062:
2035:
2015:
1969:
1959:
1912:
1875:
1859:
1824:
1816:
1775:
1714:
1694:
1648:
1604:
1596:
1396:
1282:, one of the principal physiological inhibitors of coagulation. In the presence of
1206:
1168:
421:
352:
296:
251:
2256:
Schrijver I, Houissa-Kastally R, Jones CD, Garcia KC, Zehnder JL (February 2002).
156:
2689:
2668:
2654:
2437:
2363:
2051:"C-terminal residues 621â635 of protein S are essential for binding to factor Va"
1430:
1333:
1148:
396:
180:
1729:
1538:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1520:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3027:
2325:
2308:
1944:
Proceedings of the
National Academy of Sciences of the United States of America
1429:
The complete amino acid sequence of the protein was published in 1987. In 1994
1283:
1264:
1245:
497:
24:
3073:
2840:
2764:
2719:
2067:
2050:
1653:
1636:
1378:
1366:
1325:
1222:
1195:
615:
19:
This article is about the coagulation protein. For the software company, see
1964:
1554:
557:
435:
3037:
2883:
2848:
2445:
2408:
2371:
2334:
2284:
2276:
2248:
2195:
2166:
2076:
1924:
1889:
1838:
1789:
1741:
1706:
1600:
1409:
1202:
586:
579:
414:
193:
2400:
2117:
2027:
1983:
1662:
1618:
1097:
1092:
2891:
2826:
2797:
2744:
2187:
1392:
1358:
1129:
940:
921:
2807:
2769:
2729:
2724:
2714:
2141:"Factor V and thrombotic disease: description of a janus-faced protein"
1438:
1437:, was described; this abnormality is the most common genetic cause for
1414:
1362:
1329:
1299:
1263:. The thereby activated factor V (now called FVa) is a cofactor of the
1214:
1152:
1144:
313:
210:
160:
2585:
2350:
Duga S, Asselta R, Tenchini ML (August 2004). "Coagulation factor V".
1820:
101:
97:
93:
89:
85:
39:
2906:
2863:
2858:
2853:
2739:
2734:
2019:
1454:
1434:
1400:
1388:
1341:
1279:
1229:
1225:
1210:
795:
380:
367:
279:
266:
168:
2255:
2802:
2787:
2090:
Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH (February 1993).
1337:
1317:
1272:
1268:
1256:
1252:
1081:
20:
2560:: CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V
2229:
1698:
1675:
3054:
2896:
2488:
2478:
2049:
Heeb MJ, Kojima Y, Rosing J, Tans G, Griffin JH (December 1999).
1940:"Complete cDNA and derived amino acid sequence of human factor V"
1372:
The suggestion that an additional factor might exist was made by
1354:
1125:
907:
862:
780:
776:
148:
2821:
2678:
1384:
1065:
817:
595:
2494:
1996:
2869:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
2663:
2658:
1213:), and the C2 domain mediates membrane binding. The B domain
690:
endoplasmic reticulum-Golgi intermediate compartment membrane
2473:
Overview of all the structural information available in the
2352:
1187:
Factor V protein consists of six domains: A1-A2-B-A3-C1-C2.
2683:
2213:"The relationship between FV Leiden and pulmonary embolism"
1164:
1136:
751:
endoplasmic reticulum to Golgi vesicle-mediated transport
404:
1634:
1290:
loop through which thrombin limits its own activation.
2874:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
2173:
2089:
1937:
1864:"The discovery of factor V: a tricky clotting factor"
1426:
factor VI was simply the activated form of factor V.
569:
2386:
2048:
2349:
1578:
1171:(1q24). It is genomically related to the family of
2940:Thrombin-activatable fibrinolysis inhibitor (TAFI)
2309:"Factor V: a combination of Dr Jekyll and Mr Hyde"
2145:Arteriosclerosis, Thrombosis, and Vascular Biology
1494:
1492:
1490:
1473:
1471:
1469:
1143:. Factor V deficiency leads to predisposition for
3000:Activated protein Câprotein C inhibitor (APCâPCI)
2210:
1324:. They are the most common hereditary causes for
351:
250:
3071:
2134:
1755:
1635:Thorelli E, Kaufman RJ, DahlbÀck B (June 1998).
1357:(IV) and thrombokinase (III) together acting on
135:, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
2849:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
1487:
1466:
1194:to the A domains of the copper-binding protein
1630:
1628:
1499:GRCm38: Ensembl release 89: ENSMUSG00000026579
2601:
2510:
2306:
1854:
1852:
1850:
1848:
1549:
1547:
2042:
1761:
2083:
1625:
1478:GRCh38: Ensembl release 89: ENSG00000198734
2608:
2594:
2517:
2503:
2389:Clinical Chemistry and Laboratory Medicine
1858:
1845:
1805:"F5-Atlanta: Factor V-short strikes again"
1727:
1544:
685:COPII-coated ER to Golgi transport vesicle
2917:Plasminogen activator inhibitor-2 (PAI-2)
2912:Plasminogen activator inhibitor-1 (PAI-1)
2324:
2238:
2228:
2156:
2107:
2066:
1973:
1963:
1879:
1828:
1779:
1652:
1608:
1802:
2615:
1764:"Factor V deficiency: a concise review"
766:post-translational protein modification
3072:
2710:High-molecular-weight kininogen (HMWK)
1762:Huang JN, Koerper MA (November 2008).
1251:Factor V is able to bind to activated
2589:
2498:
2307:Mann KG, Kalafatis M (January 2003).
1902:
1868:Journal of Thrombosis and Haemostasis
1809:Journal of Thrombosis and Haemostasis
1365:(I); this model had been outlined by
1147:, while some mutations (most notably
356:
317:
312:
255:
214:
209:
2995:Thrombinâantithrombin complex (TAT)
2096:The Journal of Biological Chemistry
2055:The Journal of Biological Chemistry
1641:The Journal of Biological Chemistry
13:
2902:Tissue plasminogen activator (tPA)
2859:Protein S (cofactor for protein C)
2423:
2158:10.1161/01.ATV.0000012665.51263.B7
2127:
1336:, is due to the replacement of an
1293:
512:choroid plexus of fourth ventricle
14:
3096:
2462:
2211:Hooper WC, De Staercke C (2006).
1728:Lam W, Moosavi L (18 July 2022).
1332:). The most common one of these,
16:Mammalian protein found in humans
2565:
2550:
2535:
2469:The Coagulation Factor V Protein
1881:10.1046/j.1538-7836.2003.00043.x
1781:10.1111/j.1365-2516.2008.01785.x
1320:of factor V are associated with
585:
578:
340:
333:
327:
304:
239:
232:
226:
201:
38:
2990:Prothrombin fragment 1+2 (F1+2)
2650:Platelet membrane glycoproteins
2524:
1990:
1931:
1896:
1796:
1555:"F5 gene: MedlinePlus Genetics"
1444:
1433:, resistant to inactivation by
1167:for factor V is located on the
1116:), also less commonly known as
2854:Protein C (inhibits FV, FVIII)
2487:(Coagulation factor V) at the
1721:
1669:
1572:
1526:
1508:
1275:on the cell surface membrane.
596:More reference expression data
558:More reference expression data
470:olfactory zone of nasal mucosa
1:
2426:Current Opinion in Hematology
2109:10.1016/S0021-9258(18)53854-0
1917:10.1016/S0140-6736(47)91941-7
1460:
1239:
1201:The C domains belong to the
325:
224:
2438:10.1097/MOH.0b013e3280dce51a
2364:10.1016/j.biocel.2003.08.002
1182:
695:platelet alpha granule lumen
508:Epithelium of choroid plexus
450:Epithelium of choroid plexus
7:
3080:Genes on human chromosome 1
2730:Factor XII (Hageman factor)
2644:von Willebrand factor (vWF)
1449:Factor V has been shown to
1158:
665:endoplasmic reticulum lumen
23:. For Factor V (NAD+), see
10:
3101:
3050:-antiplasmin complex (PAP)
2765:Factor III (tissue factor)
2326:10.1182/blood-2002-01-0290
2265:Thrombosis and Haemostasis
2176:Thrombosis and Haemostasis
1348:
18:
3036:
3008:
2980:
2957:
2948:
2882:
2839:
2778:
2753:
2698:
2632:
2623:
2530:
1736:. StatPearls Publishing.
1534:"Mouse PubMed Reference:"
1516:"Human PubMed Reference:"
1278:Factor Va is degraded by
1132:, encoded, in humans, by
1096:
1091:
1087:
1080:
1064:
1058:Chr 1: 163.98 â 164.05 Mb
1051:Chr 1: 169.51 â 169.59 Mb
1045:
1030:
1026:
1009:
1005:
998:
983:
979:
962:
958:
951:
938:
934:
919:
915:
906:
893:
889:
874:
870:
861:
848:
844:
829:
825:
816:
801:
794:
790:
774:
614:
610:
593:
577:
568:
555:
504:
495:
442:
433:
403:
395:
391:
374:
361:
324:
303:
294:
290:
273:
260:
223:
200:
191:
187:
142:
139:
129:
122:
117:
82:
77:
60:
55:
50:
46:
37:
32:
2972:ÎČ-Thromboglobulin (ÎČ-TG)
2068:10.1074/jbc.274.51.36187
1803:Castoldi E (July 2021).
1654:10.1074/jbc.273.26.16140
1244:Factor V is produced by
2967:Platelet factor 4 (PF4)
2864:Protein Z (inhibits FX)
2798:Prothrombin (factor II)
1965:10.1073/pnas.84.14.4846
1267:complex: The activated
1177:coagulation factor VIII
1175:, and is homologous to
3023:Fibrinopeptide B (FpB)
3018:Fibrinopeptide A (FpA)
2690:Glycoprotein VI (GPVI)
2655:Glycoprotein Ib (GPIb)
2277:10.1055/s-0037-1612988
1730:"Physiology, Factor V"
1601:10.1002/pro.5560070607
736:platelet degranulation
655:platelet alpha granule
454:pancreatic ductal cell
358:1 H2.2|1 71.46 cM
2841:Anticoagulant factors
2808:Fibrinogen (factor I)
2803:Thrombin (factor IIa)
2675:Glycoprotein IIb/IIIa
2669:Glycoprotein IX (GP9)
2636:(platelet activation)
2401:10.1515/CCLM.2006.103
1405:chronic liver disease
1209:family (unrelated to
761:response to vitamin K
756:COPII vesicle coating
705:endoplasmic reticulum
660:extracellular vesicle
3028:Fibrin monomers (FM)
2884:Fibrinolytic factors
2702:(contact activation)
2217:Respiratory Research
2188:10.1160/th07-02-0150
1399:, suggesting either
1328:(a tendency to form
1255:and is activated by
1173:multicopper oxidases
1110:Coagulation factor V
680:extracellular region
319:Chromosome 1 (mouse)
217:Chromosome 1 (human)
78:List of PDB id codes
51:Available structures
2982:Thrombin generation
2959:Platelet activation
2950:Coagulation markers
2625:Coagulation factors
2617:Coagulation cascade
2012:1994Natur.369...64B
1956:1987PNAS...84.4846J
1691:1999Natur.402..434M
1304:autosomal recessive
1280:activated protein C
715:extracellular space
446:right lobe of liver
3085:Coagulation system
2822:Fibrin (factor Ia)
2634:Primary hemostasis
1190:The A domains are
896:ENSMUSG00000026579
724:Biological process
648:Cellular component
639:copper ion binding
622:Molecular function
540:tibiofemoral joint
516:left lobe of liver
3067:
3066:
3063:
3062:
3010:Fibrin generation
2835:
2834:
2755:Extrinsic pathway
2700:Intrinsic pathway
2583:
2582:
1862:(February 2003).
1821:10.1111/jth.15351
1322:venous thrombosis
1288:negative feedback
1151:) predispose for
1107:
1106:
1103:
1102:
1076:
1075:
1041:
1040:
1020:
1019:
994:
993:
973:
972:
947:
946:
928:
927:
902:
901:
883:
882:
857:
856:
838:
837:
786:
785:
746:blood circulation
741:blood coagulation
629:metal ion binding
606:
605:
602:
601:
564:
563:
551:
550:
489:
488:
387:
386:
286:
285:
113:
112:
109:
108:
61:Ortholog search:
3092:
2955:
2954:
2630:
2629:
2610:
2603:
2596:
2587:
2586:
2569:
2554:
2539:
2519:
2512:
2505:
2496:
2495:
2457:
2420:
2383:
2346:
2328:
2303:
2301:
2295:. Archived from
2262:
2252:
2242:
2232:
2207:
2170:
2160:
2122:
2121:
2111:
2087:
2081:
2080:
2070:
2061:(51): 36187â92.
2046:
2040:
2039:
2020:10.1038/369064a0
1994:
1988:
1987:
1977:
1967:
1935:
1929:
1928:
1911:(6449): 446â48.
1900:
1894:
1893:
1883:
1856:
1843:
1842:
1832:
1815:(7): 1638â1640.
1800:
1794:
1793:
1783:
1759:
1753:
1752:
1750:
1748:
1725:
1719:
1718:
1685:(6760): 434â39.
1673:
1667:
1666:
1656:
1647:(26): 16140â45.
1632:
1623:
1622:
1612:
1579:Villoutreix BO,
1576:
1570:
1569:
1567:
1565:
1551:
1542:
1541:
1530:
1524:
1523:
1512:
1506:
1496:
1485:
1475:
1410:Second World War
1397:prothrombin time
1382:
1361:(II) to produce
1207:discoidin domain
1169:first chromosome
1089:
1088:
1060:
1053:
1036:
1024:
1023:
1015:
1003:
1002:
999:RefSeq (protein)
989:
977:
976:
968:
956:
955:
932:
931:
913:
912:
887:
886:
868:
867:
842:
841:
823:
822:
792:
791:
612:
611:
598:
589:
582:
575:
574:
560:
500:
498:Top expressed in
493:
492:
438:
436:Top expressed in
431:
430:
410:
409:
393:
392:
383:
370:
359:
344:
337:
331:
320:
308:
292:
291:
282:
269:
258:
243:
236:
230:
219:
205:
189:
188:
183:
134:
127:
104:
75:
74:
69:
48:
47:
42:
30:
29:
3100:
3099:
3095:
3094:
3093:
3091:
3090:
3089:
3070:
3069:
3068:
3059:
3049:
3032:
3004:
2976:
2944:
2934:
2925:
2878:
2831:
2774:
2757:(tissue factor)
2756:
2749:
2701:
2694:
2635:
2619:
2614:
2584:
2579:
2576:
2570:
2561:
2555:
2546:
2540:
2526:
2523:
2465:
2460:
2299:
2260:
2130:
2128:Further reading
2125:
2088:
2084:
2047:
2043:
2006:(6475): 64â67.
1995:
1991:
1950:(14): 4846â50.
1936:
1932:
1901:
1897:
1857:
1846:
1801:
1797:
1760:
1756:
1746:
1744:
1726:
1722:
1674:
1670:
1633:
1626:
1589:Protein Science
1577:
1573:
1563:
1561:
1559:medlineplus.gov
1553:
1552:
1545:
1532:
1531:
1527:
1514:
1513:
1509:
1497:
1488:
1476:
1467:
1463:
1447:
1431:factor V Leiden
1383:(1905â1990), a
1376:
1351:
1334:factor V Leiden
1296:
1294:Role in disease
1242:
1185:
1161:
1149:factor V Leiden
1098:View/Edit Mouse
1093:View/Edit Human
1056:
1049:
1046:Location (UCSC)
1032:
1011:
985:
964:
877:ENSG00000198734
770:
719:
700:Golgi apparatus
675:plasma membrane
643:
634:protein binding
594:
584:
583:
556:
547:
542:
538:
534:
530:
526:
522:
518:
514:
510:
496:
485:
480:
476:
472:
468:
464:
460:
456:
452:
448:
434:
378:
365:
357:
347:
346:
345:
338:
318:
295:Gene location (
277:
264:
256:
246:
245:
244:
237:
215:
192:Gene location (
143:
130:
123:
84:
62:
28:
17:
12:
11:
5:
3098:
3088:
3087:
3082:
3065:
3064:
3061:
3060:
3058:
3057:
3052:
3047:
3042:
3040:
3034:
3033:
3031:
3030:
3025:
3020:
3014:
3012:
3006:
3005:
3003:
3002:
2997:
2992:
2986:
2984:
2978:
2977:
2975:
2974:
2969:
2963:
2961:
2952:
2946:
2945:
2943:
2942:
2937:
2935:-Macroglobulin
2932:
2928:
2923:
2919:
2914:
2909:
2904:
2899:
2894:
2888:
2886:
2880:
2879:
2877:
2876:
2871:
2866:
2861:
2856:
2851:
2845:
2843:
2837:
2836:
2833:
2832:
2830:
2829:
2824:
2819:
2805:
2800:
2795:
2790:
2784:
2782:
2780:Common pathway
2776:
2775:
2773:
2772:
2767:
2761:
2759:
2751:
2750:
2748:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2706:
2704:
2696:
2695:
2693:
2692:
2687:
2681:
2672:
2666:
2661:
2646:
2640:
2638:
2627:
2621:
2620:
2613:
2612:
2605:
2598:
2590:
2581:
2580:
2578:
2577:
2571:
2564:
2562:
2556:
2549:
2547:
2541:
2534:
2531:
2528:
2527:
2522:
2521:
2514:
2507:
2499:
2493:
2492:
2471:
2464:
2463:External links
2461:
2459:
2458:
2421:
2384:
2358:(8): 1393â99.
2347:
2304:
2302:on 2019-03-07.
2253:
2208:
2171:
2139:(April 2002).
2131:
2129:
2126:
2124:
2123:
2102:(4): 2872â77.
2082:
2041:
1989:
1930:
1895:
1844:
1795:
1774:(6): 1164â69.
1754:
1720:
1668:
1624:
1595:(6): 1317â25.
1571:
1543:
1525:
1507:
1486:
1464:
1462:
1459:
1446:
1443:
1403:deficiency or
1350:
1347:
1295:
1292:
1284:thrombomodulin
1265:prothrombinase
1246:megakaryocytes
1241:
1238:
1228:activation by
1184:
1181:
1160:
1157:
1105:
1104:
1101:
1100:
1095:
1085:
1084:
1078:
1077:
1074:
1073:
1071:
1069:
1062:
1061:
1054:
1047:
1043:
1042:
1039:
1038:
1028:
1027:
1021:
1018:
1017:
1007:
1006:
1000:
996:
995:
992:
991:
981:
980:
974:
971:
970:
960:
959:
953:
949:
948:
945:
944:
936:
935:
929:
926:
925:
917:
916:
910:
904:
903:
900:
899:
891:
890:
884:
881:
880:
872:
871:
865:
859:
858:
855:
854:
846:
845:
839:
836:
835:
827:
826:
820:
814:
813:
808:
803:
799:
798:
788:
787:
784:
783:
772:
771:
769:
768:
763:
758:
753:
748:
743:
738:
733:
727:
725:
721:
720:
718:
717:
712:
710:Golgi membrane
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
651:
649:
645:
644:
642:
641:
636:
631:
625:
623:
619:
618:
608:
607:
604:
603:
600:
599:
591:
590:
572:
566:
565:
562:
561:
553:
552:
549:
548:
546:
545:
541:
537:
533:
529:
525:
524:lacrimal gland
521:
517:
513:
509:
505:
502:
501:
490:
487:
486:
484:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
440:
439:
427:
426:
418:
407:
401:
400:
397:RNA expression
389:
388:
385:
384:
376:
372:
371:
363:
360:
355:
349:
348:
339:
332:
326:
322:
321:
316:
310:
309:
301:
300:
288:
287:
284:
283:
275:
271:
270:
262:
259:
254:
248:
247:
238:
231:
225:
221:
220:
213:
207:
206:
198:
197:
185:
184:
181:F5 - orthologs
141:
137:
136:
128:
120:
119:
115:
114:
111:
110:
107:
106:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
25:chocolate agar
15:
9:
6:
4:
3:
2:
3097:
3086:
3083:
3081:
3078:
3077:
3075:
3056:
3053:
3051:
3044:
3043:
3041:
3039:
3035:
3029:
3026:
3024:
3021:
3019:
3016:
3015:
3013:
3011:
3007:
3001:
2998:
2996:
2993:
2991:
2988:
2987:
2985:
2983:
2979:
2973:
2970:
2968:
2965:
2964:
2962:
2960:
2956:
2953:
2951:
2947:
2941:
2938:
2936:
2929:
2927:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2889:
2887:
2885:
2881:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2846:
2844:
2842:
2838:
2828:
2825:
2823:
2820:
2817:
2813:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2785:
2783:
2781:
2777:
2771:
2768:
2766:
2763:
2762:
2760:
2758:
2752:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2720:Prekallikrein
2718:
2716:
2713:
2711:
2708:
2707:
2705:
2703:
2697:
2691:
2688:
2685:
2682:
2680:
2676:
2673:
2670:
2667:
2665:
2662:
2660:
2656:
2653:
2651:
2647:
2645:
2642:
2641:
2639:
2637:
2631:
2628:
2626:
2622:
2618:
2611:
2606:
2604:
2599:
2597:
2592:
2591:
2588:
2574:
2568:
2563:
2559:
2553:
2548:
2544:
2538:
2533:
2532:
2529:
2520:
2515:
2513:
2508:
2506:
2501:
2500:
2497:
2490:
2486:
2485:
2480:
2476:
2472:
2470:
2467:
2466:
2455:
2451:
2447:
2443:
2439:
2435:
2432:(3): 262â69.
2431:
2427:
2422:
2418:
2414:
2410:
2406:
2402:
2398:
2395:(5): 514â21.
2394:
2390:
2385:
2381:
2377:
2373:
2369:
2365:
2361:
2357:
2353:
2348:
2344:
2340:
2336:
2332:
2327:
2322:
2318:
2314:
2310:
2305:
2298:
2294:
2290:
2286:
2282:
2278:
2274:
2271:(2): 294â99.
2270:
2266:
2259:
2254:
2250:
2246:
2241:
2236:
2231:
2230:10.1186/rr180
2226:
2222:
2218:
2214:
2209:
2205:
2201:
2197:
2193:
2189:
2185:
2182:(3): 530â42.
2181:
2177:
2172:
2168:
2164:
2159:
2154:
2151:(4): 530â38.
2150:
2146:
2142:
2138:
2135:Nicolaes GA,
2133:
2132:
2119:
2115:
2110:
2105:
2101:
2097:
2093:
2086:
2078:
2074:
2069:
2064:
2060:
2056:
2052:
2045:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2009:
2005:
2001:
1993:
1985:
1981:
1976:
1971:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1934:
1926:
1922:
1918:
1914:
1910:
1906:
1899:
1891:
1887:
1882:
1877:
1874:(2): 206â13.
1873:
1869:
1865:
1861:
1855:
1853:
1851:
1849:
1840:
1836:
1831:
1826:
1822:
1818:
1814:
1810:
1806:
1799:
1791:
1787:
1782:
1777:
1773:
1769:
1765:
1758:
1743:
1739:
1735:
1731:
1724:
1716:
1712:
1708:
1704:
1700:
1699:10.1038/46594
1696:
1692:
1688:
1684:
1680:
1672:
1664:
1660:
1655:
1650:
1646:
1642:
1638:
1631:
1629:
1620:
1616:
1611:
1606:
1602:
1598:
1594:
1590:
1586:
1583:(June 1998).
1582:
1575:
1560:
1556:
1550:
1548:
1539:
1535:
1529:
1521:
1517:
1511:
1504:
1500:
1495:
1493:
1491:
1483:
1479:
1474:
1472:
1470:
1465:
1458:
1456:
1452:
1442:
1440:
1436:
1432:
1427:
1423:
1419:
1417:
1416:
1411:
1406:
1402:
1398:
1394:
1390:
1386:
1380:
1375:
1370:
1368:
1367:Paul Morawitz
1364:
1360:
1356:
1346:
1343:
1340:residue with
1339:
1335:
1331:
1327:
1326:thrombophilia
1323:
1319:
1314:
1313:
1307:
1305:
1301:
1291:
1289:
1285:
1281:
1276:
1274:
1270:
1266:
1262:
1258:
1254:
1249:
1247:
1237:
1233:
1231:
1227:
1224:
1223:anticoagulant
1220:
1216:
1212:
1208:
1204:
1199:
1197:
1196:ceruloplasmin
1193:
1188:
1180:
1178:
1174:
1170:
1166:
1156:
1154:
1150:
1146:
1142:
1138:
1135:
1131:
1127:
1123:
1122:labile factor
1119:
1115:
1111:
1099:
1094:
1090:
1086:
1083:
1079:
1072:
1070:
1067:
1063:
1059:
1055:
1052:
1048:
1044:
1037:
1035:
1029:
1025:
1022:
1016:
1014:
1008:
1004:
1001:
997:
990:
988:
982:
978:
975:
969:
967:
961:
957:
954:
952:RefSeq (mRNA)
950:
943:
942:
937:
933:
930:
924:
923:
918:
914:
911:
909:
905:
898:
897:
892:
888:
885:
879:
878:
873:
869:
866:
864:
860:
853:
852:
847:
843:
840:
834:
833:
828:
824:
821:
819:
815:
812:
809:
807:
804:
800:
797:
793:
789:
782:
778:
773:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
728:
726:
723:
722:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
652:
650:
647:
646:
640:
637:
635:
632:
630:
627:
626:
624:
621:
620:
617:
616:Gene ontology
613:
609:
597:
592:
588:
581:
576:
573:
571:
567:
559:
554:
544:parotid gland
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
506:
503:
499:
494:
491:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
428:
425:
423:
419:
417:
416:
412:
411:
408:
406:
402:
398:
394:
390:
382:
377:
373:
369:
364:
354:
350:
343:
336:
330:
323:
315:
311:
307:
302:
298:
293:
289:
281:
276:
272:
268:
263:
253:
249:
242:
235:
229:
222:
218:
212:
208:
204:
199:
195:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
138:
133:
126:
121:
116:
105:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
26:
22:
3055:D-Dimer (DD)
3038:Fibrinolysis
2926:-Antiplasmin
2792:
2648:
2572:
2557:
2542:
2482:
2429:
2425:
2392:
2388:
2355:
2351:
2319:(1): 20â30.
2316:
2312:
2297:the original
2268:
2264:
2220:
2216:
2179:
2175:
2148:
2144:
2099:
2095:
2085:
2058:
2054:
2044:
2003:
1999:
1992:
1947:
1943:
1933:
1908:
1904:
1898:
1871:
1867:
1860:Stormorken H
1812:
1808:
1798:
1771:
1767:
1757:
1745:. Retrieved
1733:
1723:
1682:
1678:
1671:
1644:
1640:
1592:
1588:
1574:
1562:. Retrieved
1558:
1537:
1528:
1519:
1510:
1448:
1445:Interactions
1428:
1424:
1420:
1413:
1371:
1352:
1315:
1311:
1308:
1297:
1277:
1250:
1243:
1234:
1203:phospholipid
1200:
1189:
1186:
1162:
1133:
1128:involved in
1121:
1118:proaccelerin
1117:
1113:
1109:
1108:
1031:
1010:
984:
963:
939:
920:
894:
875:
849:
830:
810:
805:
520:ciliary body
420:
413:
379:164,047,846
366:163,979,407
278:169,586,588
265:169,511,951
140:External IDs
83:
2892:Plasminogen
2827:Factor XIII
2745:Factor VIII
2525:PDB gallery
1768:Haemophilia
1393:menorrhagia
1377: [
1359:prothrombin
1330:blood clots
1130:coagulation
536:granulocyte
482:granulocyte
478:gallbladder
462:optic nerve
118:Identifiers
3074:Categories
2770:Factor VII
2725:Kallikrein
2715:Bradykinin
2137:DahlbÀck B
1747:7 February
1734:StatPearls
1581:DahlbÀck B
1505:, May 2017
1484:, May 2017
1461:References
1439:thrombosis
1415:The Lancet
1389:nosebleeds
1374:Paul Owren
1363:fibrinogen
1300:hemophilia
1240:Physiology
1217:acts as a
1215:C-terminus
1192:homologous
1153:thrombosis
1145:hemorrhage
731:hemostasis
424:(ortholog)
161:HomoloGene
3046:Plasmin-α
2907:Urokinase
2740:Factor IX
2735:Factor XI
1455:Protein S
1435:protein C
1418:in 1947.
1401:vitamin K
1385:Norwegian
1369:in 1905.
1342:glutamine
1318:mutations
1306:fashion.
1253:platelets
1230:protein S
1226:protein C
1211:C2 domain
1205:-binding
1183:Structure
1034:NP_032002
1013:NP_000121
987:NM_007976
966:NM_000130
796:Orthologs
169:GeneCards
2793:Factor V
2788:Factor X
2454:39904506
2446:17414217
2417:34399027
2409:16681418
2380:27193482
2372:15147718
2335:12393635
2285:11858490
2249:11806843
2223:(1): 8.
2204:29406966
2196:17849041
2167:11950687
2077:10593904
1925:20293060
1890:12871488
1839:34176223
1790:19141156
1742:31334957
1707:10586886
1501:–
1480:–
1451:interact
1338:arginine
1273:thrombin
1269:factor X
1257:thrombin
1221:for the
1219:cofactor
1159:Genetics
1141:cofactor
1114:Factor V
1082:Wikidata
775:Sources:
670:membrane
466:monocyte
458:placenta
21:Factor 5
2897:Plasmin
2489:PDBe-KB
2479:UniProt
2343:8885302
2293:4818866
2118:8428962
2036:4314040
2028:8164741
2008:Bibcode
1984:3110773
1952:Bibcode
1830:8362210
1715:4393638
1687:Bibcode
1663:9632668
1619:9655335
1610:2144041
1503:Ensembl
1482:Ensembl
1355:calcium
1349:History
1261:calcium
1126:protein
1124:, is a
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802:Species
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399:pattern
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2659:GP1BA
2450:S2CID
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2376:S2CID
2339:S2CID
2313:Blood
2300:(PDF)
2289:S2CID
2261:(PDF)
2240:64819
2200:S2CID
2032:S2CID
1711:S2CID
1564:9 May
1453:with
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851:14067
811:Mouse
806:Human
777:Amigo
528:blood
474:blood
422:Mouse
415:Human
362:Start
297:Mouse
261:Start
194:Human
157:88382
2573:1czv
2558:1czt
2543:1czs
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2368:PMID
2331:PMID
2281:PMID
2245:PMID
2192:PMID
2163:PMID
2114:PMID
2073:PMID
2024:PMID
1980:PMID
1921:PMID
1886:PMID
1835:PMID
1786:PMID
1749:2022
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1659:PMID
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532:iris
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145:OMIM
102:3P70
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2816:FGG
2812:FGA
2475:PDB
2434:doi
2397:doi
2360:doi
2321:doi
2317:101
2273:doi
2235:PMC
2225:doi
2184:doi
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2104:doi
2100:268
2063:doi
2059:274
2016:doi
2004:369
1970:PMC
1960:doi
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1876:doi
1825:PMC
1817:doi
1776:doi
1695:doi
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