449:
426:
348:
323:
3371:
3476:
3416:
3401:
3341:
714:
707:
700:
3461:
3356:
3431:
455:
354:
40:
3386:
3446:
9767:
2828:
Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN,
2326:
syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself. Analysis of chromosomal anomalies in patients led to the identification and confirmation of FGFR2 as a cleft lip and/or palate locus. On a molecular
2331:
proliferation and differentiation. Alteration in FGFR2 signalling is thought to underlie the craniosynostosis syndromes. To date, there are two mechanisms of altered FGFR2 signalling. The first is associated with constitutive activation of FGFR, where the FGFR2 receptor is always signalling,
2332:
regardless of the amount of FGF ligand. This mechanism is found in patients with
Crouzon and Pfeiffer syndrome. The second, which is associated with Apert syndrome is a loss of specificity of the FGFR2 isoform, resulting in the receptor binding to FGFs that it does not normally bind.
2027:
family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three
2314:. A phase Ib clinical study protocol has been selected for ECCO-AACR-EORTC-ESMO Workshop on Methods in Clinical Cancer Research, better known as the ‘Flims’ Workshop and clinical study of safety and preliminary efficacy of alofanib will be initiated at the beginning of 2017.
66:
2264:
is associated with a higher breast cancer risk; however the risk is only mildly increased from about 10% lifetime breast cancer risk in the average woman in the industrialized world, to 12-14% risk in carriers of the
462:
361:
2547:"Entrez Gene: FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome)"
2297:
that binds to FGFR2b (a form of FGFR2) and preventing binding of certain FGFs. In 2014, a clinical trial began to treat gastric tumours that overexpress FGFR2b. Another approach of FGFR2 targeting is use of
2560:
Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P (Aug 1993). "Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)".
3157:
Park WJ, Meyers GA, Li X, Theda C, Day D, Orlow SJ, Jones MC, Jabs EW (Jul 1995). "Novel FGFR2 mutations in
Crouzon and Jackson–Weiss syndromes show allelic heterogeneity and phenotypic variability".
2083:(pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation.
3370:
9044:
9064:
3475:
9054:
6833:
2655:
Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL (Oct 2000). "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin".
7209:
2091:
FGFR2 has two naturally occurring isoforms, FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in
4377:
3415:
3400:
2043:
domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing
2931:
Dixon MJ, Marazita ML, Beaty TH, Murray JC (2011). "Cleft lip and palate: understanding genetic and environmental influences". Nature Review
Genetics (12): 167-178.
2306:
is a novel first-in-class allosteric small-molecular inhibitor of FGFR2. It binds to the extracellular domain of FGFR2 and has an inhibitory effect on FGF2-induced
3340:
9039:
3516:
7574:
2199:
Mutations (changes) are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes) and cancer.
1587:
284:
1568:
8809:
6884:
8748:
7925:
7117:
6826:
3460:
2985:"Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain"
9708:
7850:
4367:
9432:
9345:
9290:
9244:
9189:
8924:
8864:
7865:
7795:
7354:
6952:
6894:
6342:
5968:
3494:
2420:
2402:
9427:
9305:
9204:
8990:
8879:
8679:
8639:
8387:
8306:
8168:
8109:
8071:
8016:
8011:
8001:
7875:
7870:
7840:
7815:
7810:
7800:
7686:
7605:
7544:
7472:
7451:
7436:
7389:
7042:
9527:
9385:
9364:
9320:
9300:
9219:
9199:
8914:
8894:
8874:
8517:
8512:
7845:
7569:
7102:
6899:
1927:
9350:
9340:
9295:
9249:
9239:
9194:
9018:
8985:
8965:
8929:
8919:
8869:
8829:
8301:
8281:
8248:
8129:
8031:
7880:
6819:
6392:
5553:
4347:
3355:
2303:
2067:
FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the
3274:
2942:
1934:
9310:
9209:
9104:
9008:
8960:
8953:
8939:
8884:
8854:
8334:
8324:
8276:
8258:
8187:
8021:
7860:
7805:
5209:
3533:
3509:
2222:
3430:
9049:
8739:
6265:
2290:
8344:
8061:
5900:
5691:
4940:
2546:
9149:
7329:
7012:
6241:
6006:
5910:
4928:
4706:
2499:"Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors"
3085:
McKeehan WL, Kan M (Sep 1994). "Heparan sulfate fibroblast growth factor receptor complex: structure-function relationships".
9787:
9727:
9677:
9648:
9595:
8082:
7949:
5648:
4992:
4987:
4933:
4713:
3320:
3139:
3186:
Marie PJ, Debiais F, Haÿ E (2003). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling".
2385:
1018:
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
9792:
9406:
9402:
9398:
9394:
6947:
6931:
5676:
4446:
4372:
3502:
3286:
2831:"A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer"
63:
7675:
7594:
7378:
6044:
6035:
5735:
5730:
5720:
5475:
5470:
5460:
4387:
2364:
988:
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
9797:
9390:
5929:
5920:
9079:
8198:
7758:
7369:
6542:
5711:
5440:
3259:
2068:
2024:
448:
7027:
6971:
6962:
5614:
4676:
3215:
Ibrahimi OA, Chiu ES, McCarthy JG, Mohammadi M (Jan 2005). "Understanding the molecular basis of Apert syndrome".
9601:
5244:
4738:
4424:
2389:
2368:
425:
2285:
AZD4547 is a tyrosine kinase inhibitor which targets FGFR1-3. It has demonstrated early evidence of efficacy in
9688:
9664:
8804:
8360:
8223:
5546:
4883:
4419:
3264:
2253:
2157:
1632:
3524:
3385:
2497:
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (Sep 1990).
255:, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
9654:
6698:
5759:
5380:
4852:
4847:
4792:
4526:
3975:
3379:: CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
347:
322:
1613:
9698:
8094:
7976:
7966:
6190:
6122:
6113:
5074:
4797:
2187:
These differences in binding are not surprising, since FGF ligand is known to bind to the second and third
264:
2438:
Houssaint E, Blanquet PR, Champion-Arnaud P, Gesnel MC, Torriglia A, Courtois Y, Breathnach R (Oct 1990).
9069:
6496:
6487:
6467:
6423:
6251:
4392:
3032:
Hajihosseini MK, Duarte R, Pegrum J, Donjacour A, Lana-Elola E, Rice DP, Sharpe J, Dickson C (Feb 2009).
2120:
2921:
Open-Label, Dose-Finding Study
Evaluating Safety and PK of FPA144 in Patients With Advanced Solid Tumors
461:
360:
9757:
9683:
7509:
5934:
5104:
3529:
3034:"Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model"
2341:
2232:
1998:
454:
353:
9591:
6799:
6786:
6773:
6760:
6747:
6734:
6721:
6683:
5539:
3970:
3313:
251:
7775:
7691:
7610:
7477:
7394:
6693:
6647:
6590:
5584:
5570:
5154:
4049:
3268:
2048:
2017:
1902:
1873:
1869:
1865:
1861:
1857:
1847:
1843:
1839:
1835:
1811:
1778:
1774:
1730:
1726:
1722:
1712:
1708:
1704:
1700:
272:
9375:
7122:
6997:
6595:
6308:
6299:
5118:
3445:
2072:
1003:
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
5531:
1910:
1906:
1881:
1877:
1831:
1807:
1803:
1782:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1696:
948:
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
9659:
9275:
9179:
8799:
8218:
7204:
6842:
5597:
4461:
4456:
4451:
4441:
3748:
3676:
3484:: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
2755:
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996).
9733:
7930:
7214:
6853:
6616:
6535:
6260:
5944:
3805:
3723:
2188:
2029:
336:
17:
9673:
9059:
7991:
7940:
6688:
5042:
4755:
3306:
2943:"A single-point mutation in FGFR2 affects cell cycle and Tgfbeta signalling in osteoblasts"
2664:
2609:
2451:
2299:
1308:
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
292:
8:
8814:
8228:
6652:
5958:
5069:
4888:
3424:: CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
3409:: CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
3292:
3280:
2294:
1053:
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
2668:
2613:
2455:
8492:
6845:
6585:
6332:
6323:
6151:
6142:
4476:
4210:
3240:
3228:
3110:
3063:
2903:
2855:
2830:
2786:
2737:
2688:
2514:
2270:
296:
3131:
3009:
2984:
2523:
2498:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
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1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
835:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
9119:
6376:
3232:
3203:
3174:
3145:
3135:
3102:
3055:
3014:
2965:
2895:
2860:
2778:
2729:
2680:
2637:
2632:
2597:
2578:
2528:
2479:
2474:
2439:
2237:
2080:
2051:. This particular family member is a high-affinity receptor for acidic, basic and/or
244:
56:
6811:
3349:: LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1
3244:
3067:
2907:
2790:
2741:
2107:
bone and for this reason the mutations of this gene and isoform are associated with
9537:
8669:
6631:
6626:
6600:
6528:
5653:
5639:
5249:
4982:
4903:
4466:
3659:
3585:
3224:
3195:
3166:
3127:
3114:
3094:
3045:
3004:
2996:
2957:
2887:
2850:
2842:
2768:
2719:
2692:
2672:
2627:
2617:
2570:
2518:
2510:
2469:
2459:
2323:
2227:
2208:
2108:
1223:
positive regulation of epithelial cell proliferation involved in lung morphogenesis
541:
472:
416:
371:
2920:
2878:
Katoh M, Nakagama H (Mar 2014). "FGF receptors: cancer biology and therapeutics".
276:
6678:
6662:
6575:
5895:
5885:
5880:
5860:
5855:
5850:
5845:
5840:
5831:
5566:
5309:
3845:
3840:
3763:
2961:
2307:
2040:
516:
300:
2425:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2407:
National Center for
Biotechnology Information, U.S. National Library of Medicine
9771:
9723:
9644:
9586:
9280:
9129:
9124:
8238:
8233:
6879:
6869:
6864:
6716:
6657:
6371:
6366:
6361:
5745:
5562:
5094:
4516:
4027:
3830:
2602:
Proceedings of the
National Academy of Sciences of the United States of America
2598:"Structural interactions of fibroblast growth factor receptor with its ligands"
2444:
Proceedings of the
National Academy of Sciences of the United States of America
2286:
2216:
617:
713:
706:
699:
9781:
9417:
9330:
9259:
9229:
9164:
9074:
9028:
8904:
8834:
8779:
8768:
8253:
7961:
7644:
7549:
7441:
6621:
6580:
5807:
5668:
5064:
4521:
3612:
2804:
2773:
2756:
2327:
level, mutations that affect FGFR2IIIc are associated with marked changes in
2249:
2013:
742:
2464:
677:
555:
9743:
9713:
9452:
9442:
9335:
9234:
9089:
8909:
8844:
8759:
8263:
8066:
7905:
7900:
7820:
7770:
7584:
7338:
7319:
7298:
7269:
6992:
6987:
6570:
6352:
6063:
6054:
5798:
5420:
4728:
4718:
4249:
4215:
3236:
3207:
3170:
3098:
3059:
3000:
2969:
2899:
2864:
2724:
2707:
2684:
2641:
2574:
2440:"Related fibroblast growth factor receptor genes exist in the human genome"
2310:. Principal benefits of allosteric inhibitors are high selectivity and low
2104:
2052:
1133:
fibroblast growth factor receptor signaling pathway involved in hemopoiesis
534:
313:
3178:
3149:
3106:
3018:
2782:
2733:
2582:
2532:
2483:
1974:
1969:
9703:
9669:
9567:
9557:
9552:
9542:
9492:
9315:
9214:
8975:
8889:
8819:
8714:
8477:
8442:
8392:
8355:
8291:
8173:
8104:
8056:
8046:
8041:
8036:
7920:
7915:
7910:
7288:
7199:
7189:
7157:
7152:
7147:
7142:
7132:
7092:
7057:
6794:
6729:
6565:
5430:
5079:
4857:
4832:
4531:
4153:
4079:
3553:
2622:
2096:
2044:
1677:
1658:
39:
3260:
3124:
Structural and functional diversity in the FGF receptor multigene family
2708:"Expression and biological activity of mouse fibroblast growth factor-9"
9522:
9487:
9482:
9472:
9462:
9380:
9169:
9144:
9134:
8980:
8934:
8794:
8620:
8589:
8558:
8527:
8472:
8447:
8427:
8412:
8402:
8296:
8213:
8006:
7986:
7885:
7830:
7825:
7649:
7554:
7539:
7334:
7293:
7265:
7234:
7194:
7097:
7052:
7047:
7022:
7017:
7007:
6920:
6914:
6904:
6477:
6472:
6462:
6457:
6448:
6397:
6313:
6203:
5360:
5084:
4765:
4506:
4382:
4015:
4010:
4005:
3860:
3644:
3199:
3050:
3033:
2328:
2100:
2033:
433:
330:
280:
2891:
2437:
2289:
patients with high level FGFR2 amplification (Cancer
Discovery 2016).
1343:
epithelial cell proliferation involved in salivary gland morphogenesis
830:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
9547:
9517:
9512:
9507:
9502:
9497:
9477:
9467:
9457:
9447:
9139:
9099:
8995:
8970:
8729:
8724:
8719:
8709:
8704:
8699:
8689:
8610:
8548:
8482:
8462:
8457:
8452:
8437:
8432:
8422:
8417:
8311:
8286:
8051:
7971:
7890:
7835:
7725:
7664:
7654:
7559:
7446:
7244:
7239:
7229:
7137:
7127:
7112:
7087:
7082:
7072:
7067:
7062:
6768:
6742:
5199:
5194:
5189:
5179:
5174:
5169:
5164:
3469:: Solution Structure of the D2 Domain of the Fibroblast Growth Factor
2676:
2037:
1532:
500:
487:
399:
386:
288:
9766:
9718:
9437:
9094:
8694:
8684:
8664:
8407:
8397:
7744:
7224:
7167:
7077:
7037:
6212:
5619:
5505:
5405:
5219:
5204:
4407:
4402:
4310:
4000:
2846:
2311:
2274:
2099:
organ lining, i.e. skin and internal organs. FGFR2IIIc is found in
2092:
1958:
8599:
8568:
8537:
8501:
2705:
9693:
9114:
8579:
7981:
6942:
5561:
5455:
5450:
5445:
5345:
5159:
5149:
4976:
4955:
4950:
4918:
4723:
4643:
4638:
4633:
4628:
4623:
4541:
4234:
4074:
4069:
4064:
4059:
4054:
3525:
3031:
2056:
2002:
1644:
1599:
1517:
1513:
1353:
regulation of fibroblast growth factor receptor signaling pathway
2950:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2559:
1503:
transmembrane receptor protein tyrosine kinase signaling pathway
1218:
regulation of branching involved in prostate gland morphogenesis
268:
9606:
9270:
9159:
9084:
8789:
8784:
8208:
8203:
8157:
8153:
8149:
8145:
8141:
8137:
8133:
7785:
7324:
7002:
6781:
6551:
6501:
6189:
5764:
5700:
5695:
5395:
5355:
5340:
5324:
5319:
5299:
5294:
5229:
5037:
5007:
4971:
4962:
4775:
4743:
4607:
4602:
4572:
4551:
4511:
4471:
4337:
4315:
4274:
4198:
4193:
4188:
4183:
4178:
4173:
4042:
4037:
4032:
3980:
3965:
3835:
3825:
3788:
3783:
3701:
3696:
2706:
Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (Jan 1996).
2257:
2076:
1942:
1554:
722:
3298:
2654:
9638:
9634:
9630:
9626:
9622:
9618:
9614:
9610:
9325:
9224:
8899:
8839:
8653:
8376:
8372:
8368:
8364:
7855:
7719:
7638:
7634:
7533:
7529:
7525:
7521:
7430:
7426:
7277:
6755:
6289:
6167:
6132:
6127:
6103:
5905:
5890:
5875:
5870:
5865:
5817:
5812:
5788:
5783:
5774:
5686:
5681:
5658:
5629:
5624:
5520:
5495:
5415:
5410:
5400:
5390:
5375:
5370:
5365:
5350:
5304:
5289:
5254:
5239:
5234:
5224:
5144:
5139:
5134:
5113:
5109:
5099:
5012:
4913:
4908:
4867:
4817:
4812:
4807:
4802:
4787:
4780:
4760:
4748:
4691:
4686:
4681:
4671:
4666:
4659:
4597:
4587:
4582:
4577:
4567:
4546:
4536:
4501:
4496:
4491:
4486:
4481:
4436:
4431:
4397:
4362:
4357:
4352:
4342:
4330:
4325:
4305:
4300:
4295:
4290:
4244:
4136:
4131:
3950:
3934:
3927:
3922:
3917:
3912:
3907:
3902:
3877:
3855:
3850:
3743:
3669:
3664:
3654:
3214:
2757:"Receptor specificity of the fibroblast growth factor family"
2181:
2177:
2151:
2147:
1473:
cellular response to transforming growth factor beta stimulus
1323:
mesenchymal cell differentiation involved in lung development
3126:. Advances in Cancer Research. Vol. 60. pp. 1–41.
2595:
9109:
7715:
7711:
7707:
7703:
7699:
7695:
7630:
7626:
7622:
7618:
7614:
7517:
7513:
7505:
7501:
7497:
7493:
7489:
7485:
7481:
7422:
7418:
7414:
7410:
7406:
7402:
7398:
7350:
7346:
7342:
7308:
7273:
7254:
6407:
6337:
6284:
6275:
6236:
6227:
6217:
6098:
6089:
6079:
6025:
6016:
6001:
5992:
5982:
5977:
5953:
5754:
5606:
5583:
5515:
5510:
5500:
5490:
5485:
5480:
5435:
5425:
5385:
5314:
5284:
5279:
5274:
5269:
5264:
5259:
5214:
5184:
5089:
5057:
5052:
5032:
5022:
5017:
5002:
4997:
4898:
4893:
4862:
4842:
4837:
4827:
4822:
4701:
4654:
4614:
4269:
4264:
4259:
4254:
4239:
4230:
4225:
4220:
4205:
4163:
4158:
4148:
4143:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4022:
3995:
3990:
3985:
3960:
3955:
3892:
3887:
3882:
3872:
3867:
3820:
3815:
3810:
3800:
3795:
3778:
3773:
3768:
3758:
3753:
3738:
3733:
3728:
3718:
3713:
3708:
3691:
3686:
3681:
3632:
3600:
3595:
3590:
3573:
3568:
3563:
3558:
3364:: CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
2261:
2173:
2169:
2165:
2161:
2143:
2139:
2135:
2124:
2009:
1313:
mesenchymal cell proliferation involved in lung development
6520:
1103:
branch elongation involved in salivary gland morphogenesis
6438:
6433:
6428:
6402:
5027:
3639:
3627:
3622:
3617:
3607:
3580:
3548:
2496:
1428:
positive regulation of transcription by RNA polymerase II
1268:
negative regulation of transcription by RNA polymerase II
3439:: Crystal Structure Analysis of the FGF10-FGFR2b Complex
1033:
positive regulation of cardiac muscle cell proliferation
524:
2805:"FGFR2-related craniosynostosis (Concept Id: CN231480)"
1303:
positive regulation of smooth muscle cell proliferation
821:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
766:
transmembrane receptor protein tyrosine kinase activity
9709:
Pituitary adenylate cyclase-activating peptide (PACAP)
2940:
2596:
Stauber DJ, DiGabriele AD, Hendrickson WA (Jan 2000).
2119:
Fibroblast growth factor receptor 2 has been shown to
1458:
cellular response to fibroblast growth factor stimulus
1163:
branching involved in labyrinthine layer morphogenesis
978:
positive regulation of canonical Wnt signaling pathway
9755:
6841:
1438:
phosphatidylinositol-3-phosphate biosynthetic process
1043:
positive regulation of mesenchymal cell proliferation
689:
2827:
2754:
1393:
positive regulation of cell population proliferation
1263:
regulation of morphogenesis of a branching structure
1243:
positive regulation of epithelial cell proliferation
1078:
negative regulation of epithelial cell proliferation
786:
fibroblast growth factor-activated receptor activity
1433:
phosphatidylinositol phosphate biosynthetic process
1378:
fibroblast growth factor receptor signaling pathway
9655:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
8513:Glial cell line-derived neurotrophic factor (GDNF)
8166:Cleavage products/derivatives with unknown target:
2381:
2379:
2377:
2360:
2358:
2356:
1168:branching involved in prostate gland morphogenesis
1113:branching involved in salivary gland morphogenesis
3156:
2130:The spliced isoforms, however differ in binding:
1483:positive regulation of protein kinase B signaling
471:
370:
9779:
9689:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1203:regulation of smooth muscle cell differentiation
7330:Heparin-binding EGF-like growth factor (HB-EGF)
7013:Heparin-binding EGF-like growth factor (HB-EGF)
3185:
3121:
2982:
2374:
2353:
2269:Missense mutations of FGFR2 have been found in
1023:ventricular cardiac muscle tissue morphogenesis
27:Protein-coding gene in the species Homo sapiens
2941:Lee KM, Santos-Ruiz L, Ferretti P (Mar 2010).
2386:GRCm38: Ensembl release 89: ENSMUSG00000030849
9741:Additional growth factor receptor modulators:
6827:
6536:
5547:
3510:
3314:
2877:
2202:
1373:positive regulation of phospholipase activity
8095:Insulin-like growth factor-2 (somatomedin A)
7977:Insulin-like growth factor-2 (somatomedin A)
7967:Insulin-like growth factor-1 (somatomedin C)
3025:
2934:
2648:
1148:positive regulation of Wnt signaling pathway
1068:positive regulation of ERK1 and ERK2 cascade
3084:
2976:
2748:
2699:
2589:
2365:GRCh38: Ensembl release 89: ENSG00000066468
1333:regulation of multicellular organism growth
6834:
6820:
6543:
6529:
5554:
5540:
3517:
3503:
3321:
3307:
2871:
2553:
2490:
2431:
1488:negative regulation of signal transduction
1383:regulation of smoothened signaling pathway
3534:list of human clusters of differentiation
3267:at the U.S. National Library of Medicine
3049:
3008:
2854:
2772:
2723:
2631:
2621:
2522:
2473:
2463:
2207:FGFR2 mutations are the cause of several
973:bud elongation involved in lung branching
836:transmembrane signaling receptor activity
9699:Migration-stimulating factor (MSF; PRG4)
2194:
1498:negative regulation of apoptotic process
1478:embryonic cranial skeleton morphogenesis
1048:regulation of osteoblast differentiation
932:collagen-containing extracellular matrix
887:intracellular membrane-bounded organelle
816:1-phosphatidylinositol-3-kinase activity
7028:Transforming growth factor alpha (TGFα)
1088:embryonic digestive tract morphogenesis
14:
9780:
9602:Connective tissue growth factor (CTGF)
3087:Molecular Reproduction and Development
1413:lung-associated mesenchyme development
1368:regulation of osteoblast proliferation
9665:Hepatoma-derived growth factor (HDGF)
6815:
6524:
6188:
5582:
5535:
3498:
3302:
2223:Beare-Stevenson cutis gyrata syndrome
1098:morphogenesis of embryonic epithelium
912:integral component of plasma membrane
476:
437:
432:
375:
334:
329:
2983:Webster MK, Donoghue DJ (Oct 1997).
2322:FGFR2 mutations are associated with
1423:positive regulation of cell division
1283:epithelial to mesenchymal transition
1248:ventricular zone neuroblast division
1143:lateral sprouting from an epithelium
3265:Fibroblast+Growth+Factor+Receptor+2
2761:The Journal of Biological Chemistry
2712:The Journal of Biological Chemistry
2280:
1987:Fibroblast growth factor receptor 2
1318:prostate epithelial cord elongation
1198:positive regulation of MAPK cascade
1173:regulation of ERK1 and ERK2 cascade
24:
3394:: THE FGFR2 TYROSINE KINASE DOMAIN
3229:10.1097/01.PRS.0000146703.08958.95
3217:Plastic and Reconstructive Surgery
3077:
2515:10.1002/j.1460-2075.1990.tb07454.x
1468:cellular response to retinoic acid
1273:outflow tract septum morphogenesis
1208:regulation of cell fate commitment
1013:reproductive structure development
1008:branching morphogenesis of a nerve
648:choroid plexus of fourth ventricle
25:
9809:
3253:
2829:Thomas G, Chanock SJ (Jul 2007).
2069:fibroblast growth factor receptor
2025:fibroblast growth factor receptor
2005:that in humans is encoded by the
1403:peptidyl-tyrosine phosphorylation
1158:positive regulation of cell cycle
796:protein homodimerization activity
9765:
9684:Leukemia inhibitory factor (LIF)
3474:
3459:
3444:
3429:
3414:
3399:
3384:
3369:
3354:
3339:
3122:Johnson DE, Williams LT (1993).
2055:growth factor, depending on the
2036:membrane-spanning segment and a
1073:orbitofrontal cortex development
1038:mesenchymal cell differentiation
811:protein tyrosine kinase activity
771:fibroblast growth factor binding
712:
705:
698:
586:inferior ganglion of vagus nerve
460:
453:
447:
424:
359:
352:
346:
321:
38:
8852:Negative allosteric modulators:
3328:
2925:
2914:
2821:
2797:
2114:
1398:mesodermal cell differentiation
1228:epithelial cell differentiation
983:membranous septum morphogenesis
968:embryonic pattern specification
9170:Gossypetin (3,5,7,8,3',4'-HHF)
8361:Platelet-derived growth factor
2989:Molecular and Cellular Biology
2539:
2413:
2395:
2254:single nucleotide polymorphism
2215:Acrocephalosyndactyly type 1 (
1448:response to lipopolysaccharide
1138:in utero embryonic development
877:integral component of membrane
723:More reference expression data
678:More reference expression data
13:
1:
9376:Placental growth factor (PGF)
6191:Non-receptor tyrosine kinases
3132:10.1016/S0065-230X(08)60821-0
3093:(1): 69–81, discussion 81–2.
2347:
1258:skeletal system morphogenesis
1238:multicellular organism growth
993:embryonic organ morphogenesis
445:
344:
9788:Genes on human chromosome 10
9660:Glia maturation factor (GMF)
8169:Glypromate (GPE, (1-3)IGF-1)
3188:Histology and Histopathology
2962:10.1016/j.bbadis.2009.11.006
2317:
1188:pyramidal neuron development
1063:prostate gland morphogenesis
7:
9793:Clusters of differentiation
6550:
3530:clusters of differentiation
3279:human gene location in the
2335:
2086:
2075:signal by binding to their
2062:
1408:digestive tract development
1183:mammary gland bud formation
1178:protein autophosphorylation
1128:embryonic organ development
1093:hair follicle morphogenesis
10:
9814:
9592:Colony-stimulating factors
9584:Additional growth factors:
3291:human gene details in the
2880:Medicinal Research Reviews
2342:Cluster of differentiation
2203:Craniosynostosis syndromes
2156:FGFR2IIIc binds to FGF-1,
2023:FGFR-2 is a member of the
2016:. FGFR2 is a receptor for
1999:cluster of differentiation
1193:lacrimal gland development
1083:animal organ morphogenesis
998:post-embryonic development
656:retinal pigment epithelium
9798:Tyrosine kinase receptors
9576:
9363:
9258:
9027:
8940:SNA-120 (pegylated K252a)
8767:
8758:
8738:
8652:
8629:
8598:
8567:
8536:
8500:
8491:
8343:
8186:
8119:
8112:(against IGF-1 and IGF-2)
8081:
8074:(against IGF-1 and IGF-2)
7948:
7939:
7757:
7734:
7674:
7593:
7460:
7377:
7368:
7307:
7253:
7166:
6970:
6961:
6930:
6852:
6707:
6699:Michaelis–Menten kinetics
6671:
6640:
6609:
6558:
6486:
6447:
6416:
6385:
6351:
6322:
6298:
6274:
6250:
6226:
6202:
6198:
6184:
6160:
6141:
6112:
6088:
6072:
6053:
6034:
6015:
5991:
5967:
5943:
5919:
5830:
5797:
5773:
5744:
5710:
5667:
5638:
5605:
5596:
5592:
5585:Receptor tyrosine kinases
5578:
5333:
5127:
4876:
4560:
4283:
3943:
3541:
3334:
2421:"Mouse PubMed Reference:"
2403:"Human PubMed Reference:"
2243:
1973:
1968:
1964:
1957:
1941:
1935:Chr 7: 129.76 – 132.73 Mb
1928:Chr 10: 121.48 – 121.6 Mb
1922:
1899:
1895:
1854:
1830:
1823:
1800:
1796:
1719:
1695:
1688:
1675:
1671:
1656:
1652:
1643:
1630:
1626:
1611:
1607:
1598:
1585:
1581:
1566:
1562:
1553:
1538:
1531:
1527:
1511:
1288:lung alveolus development
826:identical protein binding
741:
737:
720:
697:
688:
675:
660:medullary collecting duct
624:
615:
562:
553:
523:
515:
511:
494:
481:
444:
423:
414:
410:
393:
380:
343:
320:
311:
307:
262:
259:
249:
242:
237:
82:
77:
60:
55:
50:
46:
37:
32:
7776:Hepatocyte growth factor
7335:Neuregulins (heregulins)
7266:Neuregulins (heregulins)
7210:Trastuzumab duocarmazine
6923:(against angiopoietin 2)
6917:(against angiopoietin 3)
6591:Diffusion-limited enzyme
3269:Medical Subject Headings
3159:Human Molecular Genetics
2774:10.1074/jbc.271.25.15292
2018:fibroblast growth factor
1443:endochondral bone growth
953:ureteric bud development
831:receptor tyrosine kinase
590:external globus pallidus
574:inferior olivary nucleus
7123:Depatuxizumab mafodotin
5598:Growth factor receptors
2465:10.1073/pnas.87.20.8180
1388:inner ear morphogenesis
1293:lung lobe morphogenesis
1253:epidermis morphogenesis
1028:protein phosphorylation
781:protein kinase activity
9746:(neurotrophin mixture)
9734:Wnt signaling proteins
9415:Allosteric modulators:
9135:Norwogonin (5,7,8-THF)
7355:5 (tomoregulin, TMEFF)
7205:Trastuzumab deruxtecan
6843:Growth factor receptor
3099:10.1002/mrd.1080390112
3038:Developmental Dynamics
3001:10.1128/mcb.17.10.5739
2725:10.1074/jbc.271.3.1726
2575:10.1006/dbio.1993.1205
2233:Jackson-Weiss syndrome
2030:immunoglobulin domains
1338:otic vesicle formation
9674:T-cell growth factors
7931:Telisotuzumab vedotin
7215:Trastuzumab emtansine
6684:Eadie–Hofstee diagram
6617:Allosteric regulation
3454:: FGFR2 KINASE DOMAIN
2563:Developmental Biology
2300:allosteric inhibitors
2195:Clinical significance
2189:immunoglobulin domain
652:epithelium of trachea
337:Chromosome 10 (human)
8259:EVT-901 (SAR-127963)
7992:Mecasermin rinfabate
6694:Lineweaver–Burk plot
5669:PDGF receptor family
3171:10.1093/hmg/4.7.1229
2809:www.ncbi.nlm.nih.gov
2623:10.1073/pnas.97.1.49
2095:derived tissues and
1493:cell differentiation
1298:midbrain development
1118:cell fate commitment
892:extracellular matrix
862:extracellular region
791:transferase activity
439:Chromosome 7 (mouse)
78:List of PDB id codes
51:Available structures
6073:ROS receptor family
5607:EGF receptor family
3293:UCSC Genome Browser
3281:UCSC Genome Browser
2669:2000Natur.407.1029P
2614:2000PNAS...97...49S
2456:1990PNAS...87.8180H
2295:monoclonal antibody
2134:FGFR2IIIb binds to
1463:response to ethanol
1348:cell-cell signaling
1213:bone mineralization
1153:gland morphogenesis
922:cytoplasmic vesicle
594:subthalamic nucleus
9425:Kinase inhibitors:
9288:Kinase inhibitors:
9187:Kinase inhibitors:
8862:Kinase inhibitors:
8677:Kinase inhibitors:
8637:Kinase inhibitors:
8618:Kinase inhibitors:
8587:Kinase inhibitors:
8556:Kinase inhibitors:
8525:Kinase inhibitors:
8385:Kinase inhibitors:
7999:Kinase inhibitors:
7793:Kinase inhibitors:
7582:Kinase inhibitors:
7575:Aprutumab ixadotin
7222:Kinase inhibitors:
7035:Kinase inhibitors:
6892:Kinase inhibitors:
6653:Enzyme superfamily
6586:Enzyme promiscuity
3200:10.14670/HH-17.877
3051:10.1002/dvdy.21648
2271:endometrial cancer
1633:ENSMUSG00000030849
1358:bone morphogenesis
963:limb bud formation
941:Biological process
917:excitatory synapse
845:Cellular component
806:nucleotide binding
749:Molecular function
9753:
9752:
9359:
9358:
9120:N-Acetylserotonin
9019:ReN-1820 (TrkAd5)
8648:
8647:
8182:
8181:
8127:Binding proteins:
7786:Dihexa (PNB-0408)
7753:
7752:
7364:
7363:
7278:6 (neuroglycan C)
6998:EGF (urogastrone)
6976:
6809:
6808:
6518:
6517:
6514:
6513:
6510:
6509:
6180:
6179:
6176:
6175:
5826:
5825:
5529:
5528:
3492:
3491:
3141:978-0-12-006660-5
2892:10.1002/med.21288
2663:(6807): 1029–34.
2238:Pfeiffer syndrome
2191:of the receptor.
2103:, which includes
1984:
1983:
1980:
1979:
1953:
1952:
1918:
1917:
1889:
1888:
1819:
1818:
1790:
1789:
1684:
1683:
1665:
1664:
1639:
1638:
1620:
1619:
1594:
1593:
1575:
1574:
1523:
1522:
1108:apoptotic process
733:
732:
729:
728:
684:
683:
671:
670:
664:wall of esophagus
609:
608:
507:
506:
406:
405:
301:FGFR2 - orthologs
233:
232:
229:
228:
61:Ortholog search:
16:(Redirected from
9805:
9770:
9769:
9761:
9565:Decoy receptors:
9538:Alacizumab pegol
9016:Decoy receptors:
8765:
8764:
8670:Stem cell factor
8611:Persephin (PSPN)
8549:Neurturin (NRTN)
8498:
8497:
8335:LEVI-04 (p75-Fc)
8332:Decoy receptors:
7946:
7945:
7375:
7374:
6974:
6968:
6967:
6836:
6829:
6822:
6813:
6812:
6689:Hanes–Woolf plot
6632:Enzyme activator
6627:Enzyme inhibitor
6601:Enzyme catalysis
6545:
6538:
6531:
6522:
6521:
6200:
6199:
6186:
6185:
5640:Insulin receptor
5603:
5602:
5594:
5593:
5580:
5579:
5567:tyrosine kinases
5556:
5549:
5542:
5533:
5532:
3519:
3512:
3505:
3496:
3495:
3478:
3463:
3448:
3433:
3418:
3403:
3388:
3373:
3358:
3343:
3323:
3316:
3309:
3300:
3299:
3248:
3211:
3182:
3153:
3118:
3072:
3071:
3053:
3029:
3023:
3022:
3012:
2980:
2974:
2973:
2947:
2938:
2932:
2929:
2923:
2918:
2912:
2911:
2875:
2869:
2868:
2858:
2825:
2819:
2818:
2816:
2815:
2801:
2795:
2794:
2776:
2752:
2746:
2745:
2727:
2703:
2697:
2696:
2677:10.1038/35039551
2652:
2646:
2645:
2635:
2625:
2593:
2587:
2586:
2557:
2551:
2550:
2543:
2537:
2536:
2526:
2503:The EMBO Journal
2494:
2488:
2487:
2477:
2467:
2435:
2429:
2428:
2417:
2411:
2410:
2399:
2393:
2383:
2372:
2362:
2324:craniosynostosis
2281:As a drug target
2252:, a mutation or
2228:Crouzon syndrome
2209:craniosynostosis
2109:craniosynostosis
1993:) also known as
1966:
1965:
1937:
1930:
1913:
1893:
1892:
1884:
1828:
1827:
1824:RefSeq (protein)
1814:
1794:
1793:
1785:
1693:
1692:
1669:
1668:
1650:
1649:
1624:
1623:
1605:
1604:
1579:
1578:
1560:
1559:
1529:
1528:
1418:bone development
1123:lung development
927:receptor complex
739:
738:
725:
716:
709:
702:
695:
694:
680:
640:ventricular zone
632:genital tubercle
620:
618:Top expressed in
613:
612:
598:substantia nigra
578:ventricular zone
558:
556:Top expressed in
551:
550:
530:
529:
513:
512:
503:
490:
479:
464:
457:
451:
440:
428:
412:
411:
402:
389:
378:
363:
356:
350:
339:
325:
309:
308:
303:
254:
247:
224:
75:
74:
69:
48:
47:
42:
30:
29:
21:
9813:
9812:
9808:
9807:
9806:
9804:
9803:
9802:
9778:
9777:
9776:
9764:
9756:
9754:
9749:
9694:Midkine (NEGF2)
9572:
9355:
9254:
9023:
8961:ABT-110 (PG110)
8754:
8734:
8644:
8625:
8594:
8563:
8532:
8487:
8339:
8277:ABT-110 (PG110)
8178:
8115:
8077:
7935:
7749:
7730:
7670:
7667:(against FGF23)
7589:
7456:
7360:
7303:
7249:
7162:
6973:
6957:
6926:
6848:
6840:
6810:
6805:
6717:Oxidoreductases
6703:
6679:Enzyme kinetics
6667:
6663:List of enzymes
6636:
6605:
6576:Catalytic triad
6554:
6549:
6519:
6506:
6482:
6443:
6412:
6381:
6347:
6318:
6294:
6270:
6246:
6222:
6194:
6172:
6156:
6137:
6108:
6084:
6068:
6049:
6030:
6011:
5987:
5963:
5939:
5915:
5822:
5793:
5769:
5740:
5706:
5663:
5634:
5588:
5574:
5563:Protein kinases
5560:
5530:
5525:
5329:
5123:
4872:
4556:
4279:
3939:
3537:
3523:
3493:
3488:
3485:
3479:
3470:
3464:
3455:
3449:
3440:
3434:
3425:
3419:
3410:
3404:
3395:
3389:
3380:
3374:
3365:
3359:
3350:
3344:
3330:
3327:
3256:
3251:
3142:
3080:
3078:Further reading
3075:
3030:
3026:
2995:(10): 5739–47.
2981:
2977:
2945:
2939:
2935:
2930:
2926:
2919:
2915:
2876:
2872:
2835:Nature Genetics
2826:
2822:
2813:
2811:
2803:
2802:
2798:
2767:(25): 15292–7.
2753:
2749:
2704:
2700:
2653:
2649:
2594:
2590:
2558:
2554:
2545:
2544:
2540:
2495:
2491:
2436:
2432:
2419:
2418:
2414:
2401:
2400:
2396:
2384:
2375:
2363:
2354:
2350:
2338:
2320:
2308:phosphorylation
2283:
2260:2 of the FGFR2
2246:
2205:
2197:
2117:
2089:
2065:
2049:differentiation
2041:tyrosine kinase
1975:View/Edit Mouse
1970:View/Edit Human
1933:
1926:
1923:Location (UCSC)
1909:
1905:
1901:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1850:
1846:
1842:
1838:
1834:
1810:
1806:
1802:
1781:
1777:
1773:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1715:
1711:
1707:
1703:
1699:
1614:ENSG00000066468
1507:
1233:phosphorylation
936:
897:plasma membrane
882:Golgi apparatus
840:
801:protein binding
761:kinase activity
756:heparin binding
721:
711:
710:
704:
703:
676:
667:
662:
658:
654:
650:
646:
642:
638:
634:
630:
616:
605:
600:
596:
592:
588:
584:
580:
576:
572:
570:corpus callosum
568:
554:
498:
485:
477:
467:
466:
465:
458:
438:
415:Gene location (
397:
384:
376:
366:
365:
364:
357:
335:
312:Gene location (
263:
250:
243:
84:
62:
28:
23:
22:
15:
12:
11:
5:
9811:
9801:
9800:
9795:
9790:
9775:
9774:
9751:
9750:
9748:
9747:
9737:
9736:
9731:
9724:Thrombopoietin
9721:
9716:
9711:
9706:
9701:
9696:
9691:
9686:
9681:
9667:
9662:
9657:
9652:
9645:Erythropoietin
9642:
9604:
9599:
9589:
9587:Adrenomedullin
9580:
9578:
9574:
9573:
9571:
9570:
9561:
9560:
9555:
9550:
9545:
9540:
9531:
9530:
9525:
9520:
9515:
9510:
9505:
9500:
9495:
9490:
9485:
9480:
9475:
9470:
9465:
9460:
9455:
9450:
9445:
9440:
9435:
9430:
9421:
9420:
9411:
9410:
9388:
9383:
9378:
9369:
9367:
9361:
9360:
9357:
9356:
9354:
9353:
9348:
9343:
9338:
9333:
9328:
9323:
9318:
9313:
9308:
9303:
9298:
9293:
9284:
9283:
9278:
9273:
9264:
9262:
9256:
9255:
9253:
9252:
9247:
9242:
9237:
9232:
9227:
9222:
9217:
9212:
9207:
9202:
9197:
9192:
9183:
9182:
9173:
9172:
9167:
9162:
9153:
9152:
9147:
9142:
9137:
9132:
9127:
9122:
9117:
9112:
9107:
9102:
9097:
9092:
9087:
9082:
9077:
9072:
9067:
9062:
9057:
9052:
9050:4'-DMA-7,8-DHF
9047:
9042:
9033:
9031:
9025:
9024:
9022:
9021:
9012:
9011:
8999:
8998:
8993:
8988:
8983:
8978:
8973:
8968:
8963:
8944:
8943:
8937:
8932:
8927:
8922:
8917:
8912:
8907:
8902:
8897:
8892:
8887:
8882:
8877:
8872:
8867:
8858:
8857:
8848:
8847:
8842:
8837:
8832:
8823:
8822:
8817:
8812:
8810:Gambogic amide
8807:
8802:
8797:
8792:
8787:
8782:
8773:
8771:
8762:
8756:
8755:
8753:
8752:
8744:
8742:
8736:
8735:
8733:
8732:
8727:
8722:
8717:
8712:
8707:
8702:
8697:
8692:
8687:
8682:
8673:
8672:
8667:
8658:
8656:
8650:
8649:
8646:
8645:
8643:
8642:
8633:
8631:
8627:
8626:
8624:
8623:
8614:
8613:
8604:
8602:
8596:
8595:
8593:
8592:
8583:
8582:
8580:Artemin (ARTN)
8573:
8571:
8565:
8564:
8562:
8561:
8552:
8551:
8542:
8540:
8534:
8533:
8531:
8530:
8521:
8520:
8515:
8506:
8504:
8495:
8489:
8488:
8486:
8485:
8480:
8475:
8466:
8465:
8460:
8455:
8450:
8445:
8440:
8435:
8430:
8425:
8420:
8415:
8410:
8405:
8400:
8395:
8390:
8381:
8380:
8358:
8349:
8347:
8341:
8340:
8338:
8337:
8328:
8327:
8315:
8314:
8309:
8304:
8299:
8294:
8289:
8284:
8279:
8267:
8266:
8261:
8256:
8251:
8242:
8241:
8236:
8231:
8226:
8221:
8216:
8211:
8206:
8201:
8192:
8190:
8184:
8183:
8180:
8179:
8177:
8176:
8171:
8162:
8161:
8123:
8121:
8117:
8116:
8114:
8113:
8107:
8098:
8097:
8087:
8085:
8079:
8078:
8076:
8075:
8069:
8064:
8059:
8054:
8049:
8044:
8039:
8034:
8025:
8024:
8019:
8014:
8009:
8004:
7995:
7994:
7989:
7984:
7979:
7974:
7969:
7964:
7954:
7952:
7943:
7937:
7936:
7934:
7933:
7928:
7923:
7918:
7913:
7908:
7903:
7894:
7893:
7888:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7848:
7843:
7838:
7833:
7828:
7823:
7818:
7813:
7808:
7803:
7798:
7789:
7788:
7779:
7778:
7773:
7763:
7761:
7755:
7754:
7751:
7750:
7748:
7747:
7738:
7736:
7732:
7731:
7729:
7728:
7723:
7689:
7680:
7678:
7672:
7671:
7669:
7668:
7658:
7657:
7652:
7647:
7642:
7608:
7599:
7597:
7591:
7590:
7588:
7587:
7578:
7577:
7572:
7563:
7562:
7557:
7552:
7547:
7542:
7537:
7475:
7466:
7464:
7458:
7457:
7455:
7454:
7449:
7444:
7439:
7434:
7392:
7383:
7381:
7372:
7366:
7365:
7362:
7361:
7359:
7358:
7332:
7327:
7322:
7313:
7311:
7305:
7304:
7302:
7301:
7296:
7291:
7282:
7281:
7259:
7257:
7251:
7250:
7248:
7247:
7242:
7237:
7232:
7227:
7218:
7217:
7212:
7207:
7202:
7197:
7192:
7183:
7182:
7172:
7170:
7164:
7163:
7161:
7160:
7155:
7150:
7145:
7140:
7135:
7130:
7125:
7120:
7115:
7106:
7105:
7100:
7095:
7090:
7085:
7080:
7075:
7070:
7065:
7060:
7055:
7050:
7045:
7040:
7031:
7030:
7025:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6980:
6978:
6965:
6959:
6958:
6956:
6955:
6950:
6945:
6936:
6934:
6928:
6927:
6925:
6924:
6918:
6908:
6907:
6902:
6897:
6888:
6887:
6885:Angiopoietin 3
6882:
6880:Angiopoietin 2
6873:
6872:
6870:Angiopoietin 4
6867:
6865:Angiopoietin 1
6858:
6856:
6850:
6849:
6839:
6838:
6831:
6824:
6816:
6807:
6806:
6804:
6803:
6790:
6777:
6764:
6751:
6738:
6725:
6711:
6709:
6705:
6704:
6702:
6701:
6696:
6691:
6686:
6681:
6675:
6673:
6669:
6668:
6666:
6665:
6660:
6655:
6650:
6644:
6642:
6641:Classification
6638:
6637:
6635:
6634:
6629:
6624:
6619:
6613:
6611:
6607:
6606:
6604:
6603:
6598:
6593:
6588:
6583:
6578:
6573:
6568:
6562:
6560:
6556:
6555:
6548:
6547:
6540:
6533:
6525:
6516:
6515:
6512:
6511:
6508:
6507:
6505:
6504:
6499:
6493:
6491:
6484:
6483:
6481:
6480:
6475:
6470:
6465:
6460:
6454:
6452:
6445:
6444:
6442:
6441:
6436:
6431:
6426:
6420:
6418:
6414:
6413:
6411:
6410:
6405:
6400:
6395:
6389:
6387:
6383:
6382:
6380:
6379:
6374:
6369:
6364:
6358:
6356:
6349:
6348:
6346:
6345:
6340:
6335:
6329:
6327:
6320:
6319:
6317:
6316:
6311:
6305:
6303:
6296:
6295:
6293:
6292:
6287:
6281:
6279:
6272:
6271:
6269:
6268:
6263:
6257:
6255:
6248:
6247:
6245:
6244:
6239:
6233:
6231:
6224:
6223:
6221:
6220:
6215:
6209:
6207:
6196:
6195:
6182:
6181:
6178:
6177:
6174:
6173:
6171:
6170:
6164:
6162:
6158:
6157:
6155:
6154:
6148:
6146:
6139:
6138:
6136:
6135:
6130:
6125:
6119:
6117:
6110:
6109:
6107:
6106:
6101:
6095:
6093:
6090:AATYK receptor
6086:
6085:
6083:
6082:
6076:
6074:
6070:
6069:
6067:
6066:
6060:
6058:
6051:
6050:
6048:
6047:
6041:
6039:
6032:
6031:
6029:
6028:
6022:
6020:
6013:
6012:
6010:
6009:
6004:
5998:
5996:
5989:
5988:
5986:
5985:
5980:
5974:
5972:
5965:
5964:
5962:
5961:
5956:
5950:
5948:
5941:
5940:
5938:
5937:
5932:
5926:
5924:
5917:
5916:
5914:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5837:
5835:
5828:
5827:
5824:
5823:
5821:
5820:
5815:
5810:
5804:
5802:
5795:
5794:
5792:
5791:
5786:
5780:
5778:
5771:
5770:
5768:
5767:
5762:
5757:
5751:
5749:
5746:VEGF receptors
5742:
5741:
5739:
5738:
5733:
5728:
5723:
5717:
5715:
5708:
5707:
5705:
5704:
5698:
5689:
5684:
5679:
5673:
5671:
5665:
5664:
5662:
5661:
5656:
5651:
5645:
5643:
5636:
5635:
5633:
5632:
5627:
5622:
5617:
5611:
5609:
5600:
5590:
5589:
5576:
5575:
5559:
5558:
5551:
5544:
5536:
5527:
5526:
5524:
5523:
5518:
5513:
5508:
5503:
5498:
5493:
5488:
5483:
5478:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5343:
5337:
5335:
5331:
5330:
5328:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5131:
5129:
5125:
5124:
5122:
5121:
5116:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5061:
5060:
5055:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4990:
4985:
4980:
4974:
4965:
4960:
4959:
4958:
4953:
4943:
4938:
4937:
4936:
4931:
4921:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4880:
4878:
4874:
4873:
4871:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4784:
4783:
4778:
4768:
4763:
4758:
4753:
4752:
4751:
4746:
4741:
4731:
4726:
4721:
4716:
4711:
4710:
4709:
4704:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4663:
4662:
4657:
4647:
4641:
4636:
4631:
4626:
4617:
4612:
4611:
4610:
4605:
4600:
4590:
4585:
4580:
4575:
4570:
4564:
4562:
4558:
4557:
4555:
4554:
4549:
4544:
4539:
4534:
4529:
4524:
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4439:
4434:
4429:
4428:
4427:
4422:
4412:
4411:
4410:
4405:
4395:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4334:
4333:
4328:
4318:
4313:
4308:
4303:
4298:
4293:
4287:
4285:
4281:
4280:
4278:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4228:
4223:
4218:
4213:
4208:
4203:
4202:
4201:
4196:
4191:
4186:
4181:
4176:
4166:
4161:
4156:
4151:
4146:
4141:
4140:
4139:
4134:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4083:
4082:
4077:
4072:
4067:
4062:
4057:
4047:
4046:
4045:
4040:
4035:
4025:
4020:
4019:
4018:
4013:
4008:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3947:
3945:
3941:
3940:
3938:
3937:
3932:
3931:
3930:
3925:
3920:
3915:
3910:
3905:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3864:
3863:
3858:
3853:
3848:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3792:
3791:
3786:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3705:
3704:
3699:
3689:
3684:
3679:
3674:
3673:
3672:
3667:
3662:
3657:
3647:
3642:
3637:
3636:
3635:
3625:
3620:
3615:
3610:
3605:
3604:
3603:
3598:
3593:
3583:
3578:
3577:
3576:
3571:
3566:
3561:
3556:
3545:
3543:
3539:
3538:
3522:
3521:
3514:
3507:
3499:
3490:
3489:
3487:
3486:
3480:
3473:
3471:
3465:
3458:
3456:
3450:
3443:
3441:
3435:
3428:
3426:
3420:
3413:
3411:
3405:
3398:
3396:
3390:
3383:
3381:
3375:
3368:
3366:
3360:
3353:
3351:
3345:
3338:
3335:
3332:
3331:
3326:
3325:
3318:
3311:
3303:
3297:
3296:
3284:
3272:
3262:
3255:
3254:External links
3252:
3250:
3249:
3212:
3183:
3165:(7): 1229–33.
3154:
3140:
3119:
3081:
3079:
3076:
3074:
3073:
3024:
2975:
2933:
2924:
2913:
2886:(2): 280–300.
2870:
2847:10.1038/ng2075
2820:
2796:
2747:
2718:(3): 1726–31.
2698:
2647:
2588:
2552:
2538:
2509:(9): 2685–92.
2489:
2450:(20): 8180–4.
2430:
2412:
2394:
2373:
2351:
2349:
2346:
2345:
2344:
2337:
2334:
2319:
2316:
2287:gastric cancer
2282:
2279:
2267:
2266:
2245:
2242:
2241:
2240:
2235:
2230:
2225:
2220:
2217:Apert syndrome
2204:
2201:
2196:
2193:
2185:
2184:
2154:
2116:
2113:
2088:
2085:
2071:family, these
2064:
2061:
1982:
1981:
1978:
1977:
1972:
1962:
1961:
1955:
1954:
1951:
1950:
1948:
1946:
1939:
1938:
1931:
1924:
1920:
1919:
1916:
1915:
1897:
1896:
1890:
1887:
1886:
1852:
1851:
1825:
1821:
1820:
1817:
1816:
1798:
1797:
1791:
1788:
1787:
1717:
1716:
1690:
1686:
1685:
1682:
1681:
1673:
1672:
1666:
1663:
1662:
1654:
1653:
1647:
1641:
1640:
1637:
1636:
1628:
1627:
1621:
1618:
1617:
1609:
1608:
1602:
1596:
1595:
1592:
1591:
1583:
1582:
1576:
1573:
1572:
1564:
1563:
1557:
1551:
1550:
1545:
1540:
1536:
1535:
1525:
1524:
1521:
1520:
1509:
1508:
1506:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
944:
942:
938:
937:
935:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
848:
846:
842:
841:
839:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
752:
750:
746:
745:
735:
734:
731:
730:
727:
726:
718:
717:
692:
686:
685:
682:
681:
673:
672:
669:
668:
666:
665:
661:
657:
653:
649:
645:
644:left lung lobe
641:
637:
633:
629:
625:
622:
621:
610:
607:
606:
604:
603:
599:
595:
591:
587:
583:
579:
575:
571:
567:
563:
560:
559:
547:
546:
538:
527:
521:
520:
517:RNA expression
509:
508:
505:
504:
496:
492:
491:
483:
480:
475:
469:
468:
459:
452:
446:
442:
441:
436:
430:
429:
421:
420:
408:
407:
404:
403:
395:
391:
390:
382:
379:
374:
368:
367:
358:
351:
345:
341:
340:
333:
327:
326:
318:
317:
305:
304:
261:
257:
256:
248:
240:
239:
235:
234:
231:
230:
227:
226:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
9:
6:
4:
3:
2:
9810:
9799:
9796:
9794:
9791:
9789:
9786:
9785:
9783:
9773:
9768:
9763:
9762:
9759:
9745:
9742:
9739:
9738:
9735:
9732:
9729:
9725:
9722:
9720:
9717:
9715:
9712:
9710:
9707:
9705:
9702:
9700:
9697:
9695:
9692:
9690:
9687:
9685:
9682:
9679:
9675:
9671:
9668:
9666:
9663:
9661:
9658:
9656:
9653:
9650:
9646:
9643:
9640:
9636:
9632:
9628:
9624:
9620:
9616:
9612:
9608:
9605:
9603:
9600:
9597:
9593:
9590:
9588:
9585:
9582:
9581:
9579:
9575:
9569:
9566:
9563:
9562:
9559:
9556:
9554:
9551:
9549:
9546:
9544:
9541:
9539:
9536:
9533:
9532:
9529:
9526:
9524:
9521:
9519:
9516:
9514:
9511:
9509:
9506:
9504:
9501:
9499:
9496:
9494:
9491:
9489:
9486:
9484:
9481:
9479:
9476:
9474:
9471:
9469:
9466:
9464:
9461:
9459:
9456:
9454:
9451:
9449:
9446:
9444:
9441:
9439:
9436:
9434:
9431:
9429:
9426:
9423:
9422:
9419:
9418:Cyclotraxin B
9416:
9413:
9412:
9408:
9404:
9400:
9396:
9392:
9389:
9387:
9384:
9382:
9379:
9377:
9374:
9371:
9370:
9368:
9366:
9362:
9352:
9349:
9347:
9344:
9342:
9339:
9337:
9334:
9332:
9331:Larotrectinib
9329:
9327:
9324:
9322:
9319:
9317:
9314:
9312:
9309:
9307:
9304:
9302:
9299:
9297:
9294:
9292:
9289:
9286:
9285:
9282:
9279:
9277:
9274:
9272:
9269:
9266:
9265:
9263:
9261:
9257:
9251:
9248:
9246:
9243:
9241:
9238:
9236:
9233:
9231:
9230:Larotrectinib
9228:
9226:
9223:
9221:
9218:
9216:
9213:
9211:
9208:
9206:
9203:
9201:
9198:
9196:
9193:
9191:
9188:
9185:
9184:
9181:
9178:
9175:
9174:
9171:
9168:
9166:
9165:Cyclotraxin B
9163:
9161:
9158:
9155:
9154:
9151:
9148:
9146:
9143:
9141:
9138:
9136:
9133:
9131:
9128:
9126:
9123:
9121:
9118:
9116:
9113:
9111:
9108:
9106:
9103:
9101:
9098:
9096:
9093:
9091:
9088:
9086:
9083:
9081:
9078:
9076:
9075:Amitriptyline
9073:
9071:
9068:
9066:
9063:
9061:
9058:
9056:
9053:
9051:
9048:
9046:
9043:
9041:
9038:
9035:
9034:
9032:
9030:
9026:
9020:
9017:
9014:
9013:
9010:
9007:
9004:
9001:
9000:
8997:
8994:
8992:
8989:
8987:
8984:
8982:
8979:
8977:
8974:
8972:
8969:
8967:
8964:
8962:
8959:
8955:
8952:
8951:Against TrkA:
8949:
8946:
8945:
8941:
8938:
8936:
8933:
8931:
8928:
8926:
8923:
8921:
8918:
8916:
8913:
8911:
8908:
8906:
8905:Larotrectinib
8903:
8901:
8898:
8896:
8893:
8891:
8888:
8886:
8883:
8881:
8878:
8876:
8873:
8871:
8868:
8866:
8863:
8860:
8859:
8856:
8853:
8850:
8849:
8846:
8843:
8841:
8838:
8836:
8835:Dexamethasone
8833:
8831:
8828:
8825:
8824:
8821:
8818:
8816:
8813:
8811:
8808:
8806:
8803:
8801:
8798:
8796:
8793:
8791:
8788:
8786:
8783:
8781:
8780:Amitriptyline
8778:
8775:
8774:
8772:
8770:
8766:
8763:
8761:
8757:
8750:
8746:
8745:
8743:
8741:
8737:
8731:
8728:
8726:
8723:
8721:
8718:
8716:
8713:
8711:
8708:
8706:
8703:
8701:
8698:
8696:
8693:
8691:
8688:
8686:
8683:
8681:
8678:
8675:
8674:
8671:
8668:
8666:
8663:
8660:
8659:
8657:
8655:
8651:
8641:
8638:
8635:
8634:
8632:
8628:
8622:
8619:
8616:
8615:
8612:
8609:
8606:
8605:
8603:
8601:
8597:
8591:
8588:
8585:
8584:
8581:
8578:
8575:
8574:
8572:
8570:
8566:
8560:
8557:
8554:
8553:
8550:
8547:
8544:
8543:
8541:
8539:
8535:
8529:
8526:
8523:
8522:
8519:
8516:
8514:
8511:
8508:
8507:
8505:
8503:
8499:
8496:
8494:
8490:
8484:
8481:
8479:
8476:
8474:
8471:
8468:
8467:
8464:
8461:
8459:
8456:
8454:
8451:
8449:
8446:
8444:
8441:
8439:
8436:
8434:
8431:
8429:
8426:
8424:
8421:
8419:
8416:
8414:
8411:
8409:
8406:
8404:
8401:
8399:
8396:
8394:
8391:
8389:
8386:
8383:
8382:
8378:
8374:
8370:
8366:
8362:
8359:
8357:
8354:
8351:
8350:
8348:
8346:
8342:
8336:
8333:
8330:
8329:
8326:
8323:
8320:
8317:
8316:
8313:
8310:
8308:
8305:
8303:
8300:
8298:
8295:
8293:
8290:
8288:
8285:
8283:
8280:
8278:
8275:
8272:
8269:
8268:
8265:
8262:
8260:
8257:
8255:
8254:Dexamethasone
8252:
8250:
8247:
8244:
8243:
8240:
8237:
8235:
8232:
8230:
8227:
8225:
8222:
8220:
8217:
8215:
8212:
8210:
8207:
8205:
8202:
8200:
8197:
8194:
8193:
8191:
8189:
8185:
8175:
8172:
8170:
8167:
8164:
8163:
8159:
8155:
8151:
8147:
8143:
8139:
8135:
8131:
8128:
8125:
8124:
8122:
8118:
8111:
8108:
8106:
8103:
8100:
8099:
8096:
8092:
8089:
8088:
8086:
8084:
8080:
8073:
8070:
8068:
8065:
8063:
8060:
8058:
8055:
8053:
8050:
8048:
8045:
8043:
8040:
8038:
8035:
8033:
8030:
8027:
8026:
8023:
8020:
8018:
8015:
8013:
8010:
8008:
8005:
8003:
8000:
7997:
7996:
7993:
7990:
7988:
7985:
7983:
7980:
7978:
7975:
7973:
7970:
7968:
7965:
7963:
7962:des(1-3)IGF-1
7959:
7956:
7955:
7953:
7951:
7947:
7944:
7942:
7938:
7932:
7929:
7927:
7926:Telisotuzumab
7924:
7922:
7919:
7917:
7914:
7912:
7909:
7907:
7904:
7902:
7899:
7896:
7895:
7892:
7889:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7847:
7844:
7842:
7839:
7837:
7834:
7832:
7829:
7827:
7824:
7822:
7819:
7817:
7814:
7812:
7809:
7807:
7804:
7802:
7799:
7797:
7794:
7791:
7790:
7787:
7784:
7783:Potentiators:
7781:
7780:
7777:
7774:
7772:
7768:
7765:
7764:
7762:
7760:
7756:
7746:
7743:
7740:
7739:
7737:
7733:
7727:
7724:
7721:
7717:
7713:
7709:
7705:
7701:
7697:
7693:
7690:
7688:
7685:
7682:
7681:
7679:
7677:
7673:
7666:
7663:
7660:
7659:
7656:
7653:
7651:
7648:
7646:
7645:Selpercatinib
7643:
7640:
7636:
7632:
7628:
7624:
7620:
7616:
7612:
7609:
7607:
7604:
7601:
7600:
7598:
7596:
7592:
7586:
7583:
7580:
7579:
7576:
7573:
7571:
7568:
7565:
7564:
7561:
7558:
7556:
7553:
7551:
7550:Selpercatinib
7548:
7546:
7543:
7541:
7538:
7535:
7531:
7527:
7523:
7519:
7515:
7511:
7507:
7503:
7499:
7495:
7491:
7487:
7483:
7479:
7476:
7474:
7471:
7468:
7467:
7465:
7463:
7459:
7453:
7450:
7448:
7445:
7443:
7442:Selpercatinib
7440:
7438:
7435:
7432:
7428:
7424:
7420:
7416:
7412:
7408:
7404:
7400:
7396:
7393:
7391:
7388:
7385:
7384:
7382:
7380:
7376:
7373:
7371:
7367:
7356:
7352:
7348:
7344:
7340:
7336:
7333:
7331:
7328:
7326:
7323:
7321:
7318:
7315:
7314:
7312:
7310:
7306:
7300:
7297:
7295:
7292:
7290:
7287:
7284:
7283:
7279:
7275:
7271:
7267:
7264:
7261:
7260:
7258:
7256:
7252:
7246:
7243:
7241:
7238:
7236:
7233:
7231:
7228:
7226:
7223:
7220:
7219:
7216:
7213:
7211:
7208:
7206:
7203:
7201:
7198:
7196:
7193:
7191:
7188:
7185:
7184:
7181:
7177:
7174:
7173:
7171:
7169:
7165:
7159:
7156:
7154:
7151:
7149:
7146:
7144:
7141:
7139:
7136:
7134:
7131:
7129:
7126:
7124:
7121:
7119:
7118:Depatuxizumab
7116:
7114:
7111:
7108:
7107:
7104:
7101:
7099:
7096:
7094:
7091:
7089:
7086:
7084:
7081:
7079:
7076:
7074:
7071:
7069:
7066:
7064:
7061:
7059:
7056:
7054:
7051:
7049:
7046:
7044:
7041:
7039:
7036:
7033:
7032:
7029:
7026:
7024:
7021:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6985:
6982:
6981:
6979:
6977:
6969:
6966:
6964:
6960:
6954:
6951:
6949:
6946:
6944:
6941:
6938:
6937:
6935:
6933:
6929:
6922:
6919:
6916:
6913:
6910:
6909:
6906:
6903:
6901:
6898:
6896:
6893:
6890:
6889:
6886:
6883:
6881:
6878:
6875:
6874:
6871:
6868:
6866:
6863:
6860:
6859:
6857:
6855:
6851:
6847:
6844:
6837:
6832:
6830:
6825:
6823:
6818:
6817:
6814:
6801:
6797:
6796:
6791:
6788:
6784:
6783:
6778:
6775:
6771:
6770:
6765:
6762:
6758:
6757:
6752:
6749:
6745:
6744:
6739:
6736:
6732:
6731:
6726:
6723:
6719:
6718:
6713:
6712:
6710:
6706:
6700:
6697:
6695:
6692:
6690:
6687:
6685:
6682:
6680:
6677:
6676:
6674:
6670:
6664:
6661:
6659:
6658:Enzyme family
6656:
6654:
6651:
6649:
6646:
6645:
6643:
6639:
6633:
6630:
6628:
6625:
6623:
6622:Cooperativity
6620:
6618:
6615:
6614:
6612:
6608:
6602:
6599:
6597:
6594:
6592:
6589:
6587:
6584:
6582:
6581:Oxyanion hole
6579:
6577:
6574:
6572:
6569:
6567:
6564:
6563:
6561:
6557:
6553:
6546:
6541:
6539:
6534:
6532:
6527:
6526:
6523:
6503:
6500:
6498:
6495:
6494:
6492:
6489:
6485:
6479:
6476:
6474:
6471:
6469:
6466:
6464:
6461:
6459:
6456:
6455:
6453:
6450:
6446:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6422:
6421:
6419:
6415:
6409:
6406:
6404:
6401:
6399:
6396:
6394:
6391:
6390:
6388:
6384:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6360:
6359:
6357:
6354:
6350:
6344:
6341:
6339:
6336:
6334:
6331:
6330:
6328:
6325:
6321:
6315:
6312:
6310:
6307:
6306:
6304:
6301:
6297:
6291:
6288:
6286:
6283:
6282:
6280:
6277:
6273:
6267:
6264:
6262:
6259:
6258:
6256:
6253:
6249:
6243:
6240:
6238:
6235:
6234:
6232:
6229:
6225:
6219:
6216:
6214:
6211:
6210:
6208:
6205:
6201:
6197:
6193:(EC 2.7.10.2)
6192:
6187:
6183:
6169:
6166:
6165:
6163:
6161:uncategorised
6159:
6153:
6150:
6149:
6147:
6144:
6140:
6134:
6131:
6129:
6126:
6124:
6121:
6120:
6118:
6115:
6111:
6105:
6102:
6100:
6097:
6096:
6094:
6091:
6087:
6081:
6078:
6077:
6075:
6071:
6065:
6062:
6061:
6059:
6056:
6055:MuSK receptor
6052:
6046:
6043:
6042:
6040:
6037:
6033:
6027:
6024:
6023:
6021:
6018:
6017:PTK7 receptor
6014:
6008:
6005:
6003:
6000:
5999:
5997:
5994:
5990:
5984:
5981:
5979:
5976:
5975:
5973:
5970:
5966:
5960:
5957:
5955:
5952:
5951:
5949:
5946:
5942:
5936:
5933:
5931:
5928:
5927:
5925:
5922:
5918:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5838:
5836:
5833:
5829:
5819:
5816:
5814:
5811:
5809:
5806:
5805:
5803:
5800:
5796:
5790:
5787:
5785:
5782:
5781:
5779:
5776:
5772:
5766:
5763:
5761:
5758:
5756:
5753:
5752:
5750:
5747:
5743:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5718:
5716:
5713:
5709:
5702:
5699:
5697:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5674:
5672:
5670:
5666:
5660:
5657:
5655:
5652:
5650:
5647:
5646:
5644:
5641:
5637:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5612:
5610:
5608:
5604:
5601:
5599:
5595:
5591:
5587:(EC 2.7.10.1)
5586:
5581:
5577:
5572:
5568:
5564:
5557:
5552:
5550:
5545:
5543:
5538:
5537:
5534:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5502:
5499:
5497:
5494:
5492:
5489:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5338:
5336:
5332:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5132:
5130:
5126:
5120:
5117:
5115:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5059:
5056:
5054:
5051:
5050:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4978:
4975:
4973:
4969:
4966:
4964:
4961:
4957:
4954:
4952:
4949:
4948:
4947:
4944:
4942:
4939:
4935:
4932:
4930:
4927:
4926:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4881:
4879:
4875:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4782:
4779:
4777:
4774:
4773:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4750:
4747:
4745:
4742:
4740:
4737:
4736:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4708:
4705:
4703:
4700:
4699:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4661:
4658:
4656:
4653:
4652:
4651:
4648:
4645:
4642:
4640:
4637:
4635:
4632:
4630:
4627:
4625:
4621:
4618:
4616:
4613:
4609:
4606:
4604:
4601:
4599:
4596:
4595:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4565:
4563:
4559:
4553:
4550:
4548:
4545:
4543:
4540:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4435:
4433:
4430:
4426:
4423:
4421:
4418:
4417:
4416:
4413:
4409:
4406:
4404:
4401:
4400:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4332:
4329:
4327:
4324:
4323:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4288:
4286:
4282:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4171:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4138:
4135:
4133:
4130:
4129:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4052:
4051:
4048:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4029:
4026:
4024:
4021:
4017:
4014:
4012:
4009:
4007:
4004:
4003:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3948:
3946:
3942:
3936:
3933:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3900:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3843:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3790:
3787:
3785:
3782:
3781:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3703:
3700:
3698:
3695:
3694:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3652:
3651:
3648:
3646:
3643:
3641:
3638:
3634:
3631:
3630:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3602:
3599:
3597:
3594:
3592:
3589:
3588:
3587:
3584:
3582:
3579:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3551:
3550:
3547:
3546:
3544:
3540:
3535:
3531:
3527:
3520:
3515:
3513:
3508:
3506:
3501:
3500:
3497:
3483:
3477:
3472:
3468:
3462:
3457:
3453:
3447:
3442:
3438:
3432:
3427:
3423:
3417:
3412:
3408:
3402:
3397:
3393:
3387:
3382:
3378:
3372:
3367:
3363:
3357:
3352:
3348:
3342:
3337:
3336:
3333:
3324:
3319:
3317:
3312:
3310:
3305:
3304:
3301:
3294:
3290:
3289:
3285:
3282:
3278:
3277:
3273:
3270:
3266:
3263:
3261:
3258:
3257:
3246:
3242:
3238:
3234:
3230:
3226:
3223:(1): 264–70.
3222:
3218:
3213:
3209:
3205:
3201:
3197:
3194:(3): 877–85.
3193:
3189:
3184:
3180:
3176:
3172:
3168:
3164:
3160:
3155:
3151:
3147:
3143:
3137:
3133:
3129:
3125:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3092:
3088:
3083:
3082:
3069:
3065:
3061:
3057:
3052:
3047:
3044:(2): 376–85.
3043:
3039:
3035:
3028:
3020:
3016:
3011:
3006:
3002:
2998:
2994:
2990:
2986:
2979:
2971:
2967:
2963:
2959:
2956:(3): 347–55.
2955:
2951:
2944:
2937:
2928:
2922:
2917:
2909:
2905:
2901:
2897:
2893:
2889:
2885:
2881:
2874:
2866:
2862:
2857:
2852:
2848:
2844:
2840:
2836:
2832:
2824:
2810:
2806:
2800:
2792:
2788:
2784:
2780:
2775:
2770:
2766:
2762:
2758:
2751:
2743:
2739:
2735:
2731:
2726:
2721:
2717:
2713:
2709:
2702:
2694:
2690:
2686:
2682:
2678:
2674:
2670:
2666:
2662:
2658:
2651:
2643:
2639:
2634:
2629:
2624:
2619:
2615:
2611:
2607:
2603:
2599:
2592:
2584:
2580:
2576:
2572:
2569:(2): 475–86.
2568:
2564:
2556:
2548:
2542:
2534:
2530:
2525:
2520:
2516:
2512:
2508:
2504:
2500:
2493:
2485:
2481:
2476:
2471:
2466:
2461:
2457:
2453:
2449:
2445:
2441:
2434:
2426:
2422:
2416:
2408:
2404:
2398:
2391:
2387:
2382:
2380:
2378:
2370:
2366:
2361:
2359:
2357:
2352:
2343:
2340:
2339:
2333:
2330:
2325:
2315:
2313:
2309:
2305:
2301:
2296:
2292:
2288:
2278:
2276:
2272:
2263:
2259:
2255:
2251:
2250:Breast cancer
2248:
2247:
2239:
2236:
2234:
2231:
2229:
2226:
2224:
2221:
2218:
2214:
2213:
2212:
2210:
2200:
2192:
2190:
2183:
2179:
2175:
2171:
2167:
2163:
2159:
2155:
2153:
2149:
2145:
2141:
2137:
2133:
2132:
2131:
2128:
2126:
2122:
2112:
2110:
2106:
2102:
2098:
2094:
2084:
2082:
2078:
2074:
2070:
2060:
2058:
2054:
2050:
2046:
2042:
2039:
2035:
2031:
2026:
2021:
2019:
2015:
2014:chromosome 10
2011:
2008:
2004:
2000:
1996:
1992:
1988:
1976:
1971:
1967:
1963:
1960:
1956:
1949:
1947:
1944:
1940:
1936:
1932:
1929:
1925:
1921:
1914:
1912:
1908:
1904:
1898:
1894:
1891:
1885:
1883:
1879:
1875:
1871:
1867:
1863:
1859:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1826:
1822:
1815:
1813:
1809:
1805:
1799:
1795:
1792:
1786:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1718:
1714:
1710:
1706:
1702:
1698:
1694:
1691:
1689:RefSeq (mRNA)
1687:
1680:
1679:
1674:
1670:
1667:
1661:
1660:
1655:
1651:
1648:
1646:
1642:
1635:
1634:
1629:
1625:
1622:
1616:
1615:
1610:
1606:
1603:
1601:
1597:
1590:
1589:
1584:
1580:
1577:
1571:
1570:
1565:
1561:
1558:
1556:
1552:
1549:
1546:
1544:
1541:
1537:
1534:
1530:
1526:
1519:
1515:
1510:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1453:wound healing
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1396:
1394:
1391:
1389:
1386:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1361:
1359:
1356:
1354:
1351:
1349:
1346:
1344:
1341:
1339:
1336:
1334:
1331:
1329:
1326:
1324:
1321:
1319:
1316:
1314:
1311:
1309:
1306:
1304:
1301:
1299:
1296:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1278:odontogenesis
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1214:
1211:
1209:
1206:
1204:
1201:
1199:
1196:
1194:
1191:
1189:
1186:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1161:
1159:
1156:
1154:
1151:
1149:
1146:
1144:
1141:
1139:
1136:
1134:
1131:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1101:
1099:
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
945:
943:
940:
939:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
849:
847:
844:
843:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
748:
747:
744:
743:Gene ontology
740:
736:
724:
719:
715:
708:
701:
696:
693:
691:
687:
679:
674:
663:
659:
655:
651:
647:
643:
639:
636:adrenal gland
635:
631:
627:
626:
623:
619:
614:
611:
602:skin of thigh
601:
597:
593:
589:
585:
582:parotid gland
581:
577:
573:
569:
565:
564:
561:
557:
552:
549:
548:
545:
543:
539:
537:
536:
532:
531:
528:
526:
522:
518:
514:
510:
502:
497:
493:
489:
484:
474:
470:
463:
456:
450:
443:
435:
431:
427:
422:
418:
413:
409:
401:
396:
392:
388:
383:
373:
369:
362:
355:
349:
342:
338:
332:
328:
324:
319:
315:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
258:
253:
246:
241:
236:
225:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
9744:Cerebrolysin
9740:
9714:Pleiotrophin
9670:Interleukins
9583:
9564:
9534:
9453:Fruquintinib
9443:Cabozantinib
9424:
9414:
9372:
9336:Lestaurtinib
9287:
9267:
9235:Lestaurtinib
9186:
9176:
9157:Antagonists:
9156:
9090:Deoxygedunin
9045:3,7,8,2'-THF
9036:
9015:
9006:Against NGF:
9005:
9002:
8958:Against NGF:
8957:
8950:
8947:
8910:Lestaurtinib
8861:
8851:
8845:Testosterone
8827:Antagonists:
8826:
8776:
8676:
8661:
8636:
8617:
8607:
8586:
8576:
8555:
8545:
8524:
8509:
8469:
8384:
8352:
8331:
8322:Against NGF:
8321:
8318:
8274:Against NGF:
8273:
8270:
8264:Testosterone
8246:Antagonists:
8245:
8195:
8165:
8126:
8101:
8090:
8067:Teprotumumab
8028:
7998:
7957:
7906:Ficlatuzumab
7901:Emibetuzumab
7897:
7851:JNJ-38877605
7821:Cabozantinib
7792:
7782:
7771:Fosgonimeton
7766:
7741:
7683:
7661:
7602:
7585:Infigratinib
7581:
7566:
7469:
7461:
7386:
7320:Betacellulin
7316:
7299:Seribantumab
7285:
7262:
7221:
7186:
7180:Unknown/none
7179:
7175:
7109:
7034:
6993:Betacellulin
6988:Amphiregulin
6983:
6975:(ErbB1/HER1)
6939:
6911:
6891:
6877:Antagonists:
6876:
6861:
6854:Angiopoietin
6795:Translocases
6792:
6779:
6766:
6753:
6740:
6730:Transferases
6727:
6714:
6571:Binding site
6417:SRC-B family
6386:SRC-A family
6143:RET receptor
6114:AXL receptor
6036:RYK receptor
5993:DDR receptor
5969:ROR receptor
5945:TIE receptor
5921:LTK receptor
5832:EPH receptor
5799:Trk receptor
5775:HGF receptor
5725:
5712:FGF receptor
5465:
5047:
4967:
4945:
4923:
4770:
4733:
4696:
4649:
4619:
4592:
4414:
4320:
4168:
3897:
3649:
3481:
3466:
3451:
3436:
3421:
3406:
3391:
3376:
3361:
3346:
3287:
3275:
3220:
3216:
3191:
3187:
3162:
3158:
3123:
3090:
3086:
3041:
3037:
3027:
2992:
2988:
2978:
2953:
2949:
2936:
2927:
2916:
2883:
2879:
2873:
2841:(7): 870–4.
2838:
2834:
2823:
2812:. Retrieved
2808:
2799:
2764:
2760:
2750:
2715:
2711:
2701:
2660:
2656:
2650:
2608:(1): 49–54.
2605:
2601:
2591:
2566:
2562:
2555:
2541:
2506:
2502:
2492:
2447:
2443:
2433:
2424:
2415:
2406:
2397:
2321:
2284:
2268:
2206:
2198:
2186:
2129:
2118:
2115:Interactions
2105:craniofacial
2090:
2081:dimerisation
2066:
2053:keratinocyte
2022:
2012:residing on
2006:
1994:
1990:
1986:
1985:
1903:NP_001334567
1900:
1874:NP_001307587
1870:NP_001307583
1866:NP_001138391
1862:NP_001138390
1858:NP_001138389
1855:
1848:NP_001138388
1844:NP_001138387
1840:NP_001138386
1836:NP_001138385
1812:NM_001347638
1801:
1779:NM_001320658
1775:NM_001320654
1731:NM_001144919
1727:NM_001144918
1723:NM_001144917
1720:
1713:NM_001144916
1709:NM_001144915
1705:NM_001144914
1701:NM_001144913
1676:
1657:
1631:
1612:
1586:
1567:
1547:
1542:
1363:MAPK cascade
1328:axonogenesis
1058:angiogenesis
958:organ growth
872:cell surface
540:
533:
499:132,725,079
486:129,764,181
398:121,598,458
385:121,478,332
260:External IDs
83:
9704:Oncomodulin
9568:Aflibercept
9558:Ranibizumab
9553:Ramucirumab
9543:Bevacizumab
9535:Antibodies:
9493:Regorafenib
9433:Altiratinib
9346:ONO-5390556
9316:Entrectinib
9291:Altiratinib
9245:ONO-5390556
9215:Entrectinib
9190:Altiratinib
8976:Frunevetmab
8948:Antibodies:
8925:ONO-5390556
8890:Entrectinib
8865:Altiratinib
8820:Tavilermide
8715:Quizartinib
8654:SCF (c-Kit)
8478:Ramucirumab
8470:Antibodies:
8443:Quizartinib
8393:Avapritinib
8356:Becaplermin
8292:Frunevetmab
8271:Antibodies:
8174:Trofinetide
8105:Dusigitumab
8102:Antibodies:
8057:Robatumumab
8047:Figitumumab
8042:Dalotuzumab
8037:Cixutumumab
8029:Antibodies:
7921:Rilotumumab
7916:Onartuzumab
7911:Flanvotumab
7898:Antibodies:
7866:PF-04217903
7796:Altiratinib
7759:HGF (c-Met)
7662:Antibodies:
7567:Antibodies:
7289:Duligotumab
7286:Antibodies:
7200:Trastuzumab
7190:Ertumaxomab
7187:Antibodies:
7158:Zalutumumab
7153:Panitumumab
7148:Nimotuzumab
7143:Necitumumab
7133:Imgatuzumab
7110:Antibodies:
7093:Osimertinib
7058:Dacomitinib
6953:Dapiclermin
6912:Antibodies:
6895:Altiratinib
6566:Active site
3329:PDB gallery
2211:syndromes:
2097:endothelial
2045:mitogenesis
2038:cytoplasmic
2034:hydrophobic
2032:, a single
907:cell cortex
902:nucleoplasm
776:ATP binding
478:7|7 F3
238:Identifiers
9782:Categories
9523:Vandetanib
9488:Rebastinib
9483:Pegaptanib
9473:Nintedanib
9463:Lenvatinib
9428:Agerafenib
9381:Ripretinib
9306:CH-7057288
9205:CH-7057288
9070:7,8,3'-THF
9065:7,8,2'-THF
8991:Ranevetmab
8981:Fulranumab
8935:Rebastinib
8880:CH-7057288
8795:Cenegermin
8680:Agerafenib
8640:Agerafenib
8621:Vandetanib
8590:Vandetanib
8559:Vandetanib
8528:Vandetanib
8473:Olaratumab
8448:Ripretinib
8428:Nintedanib
8413:Lenvatinib
8403:Crenolanib
8388:Agerafenib
8307:Ranevetmab
8297:Fulranumab
8214:Cenegermin
8188:LNGF (p75)
8110:Xentuzumab
8072:Xentuzumab
8017:NVP-AEW541
8012:NVP-ADW742
8007:Linsitinib
8002:BMS-754807
7987:Mecasermin
7886:Tivantinib
7876:PHA-665752
7871:PF-2341066
7841:Golvatinib
7831:Crizotinib
7826:Capmatinib
7816:BMS-777607
7811:Amuvatinib
7687:Ersofermin
7650:Sprifermin
7606:Ersofermin
7555:Sprifermin
7545:Repifermin
7540:Palifermin
7473:Ersofermin
7452:Velafermin
7437:Repifermin
7390:Ersofermin
7309:ErbB4/HER4
7294:Patritumab
7255:ErbB3/HER3
7235:Mubritinib
7195:Pertuzumab
7168:ErbB2/HER2
7098:Vandetanib
7053:Canertinib
7048:Brigatinib
7043:Agerafenib
7023:Nepidermin
7018:Murodermin
7008:Epiregulin
6963:EGF (ErbB)
6921:Nesvacumab
6915:Evinacumab
6905:Rebastinib
6846:modulators
6769:Isomerases
6743:Hydrolases
6610:Regulation
3532:(see also
2814:2023-07-17
2392:, May 2017
2371:, May 2017
2348:References
2329:osteoblast
2101:mesenchyme
2001:332) is a
566:C1 segment
544:(ortholog)
281:HomoloGene
9548:Icrucumab
9528:WHI-P 154
9518:Tivozanib
9513:Toceranib
9508:Sunitinib
9503:Sorafenib
9498:Semaxanib
9478:Pazopanib
9468:Motesanib
9458:Lapatinib
9448:Cediranib
9386:Telbermin
9373:Agonists:
9321:GZ-389988
9301:CE-245677
9268:Agonists:
9220:GZ-389988
9200:CE-245677
9100:Diosmetin
9037:Agonists:
9003:Aptamers:
8996:Tanezumab
8971:Fasinumab
8915:Milciclib
8895:GZ-389988
8875:CE-245677
8777:Agonists:
8730:Toceranib
8725:Sunitinib
8720:Sorafenib
8710:Pazopanib
8705:Nilotinib
8700:Masitinib
8690:Dasatinib
8662:Agonists:
8608:Agonists:
8577:Agonists:
8546:Agonists:
8518:Liatermin
8510:Agonists:
8493:RET (GFL)
8483:Tovetumab
8463:Toceranib
8458:Sorafenib
8453:Sunitinib
8438:Radotinib
8433:Pazopanib
8423:Motesanib
8418:Masitinib
8353:Agonists:
8319:Aptamers:
8312:Tanezumab
8287:Fasinumab
8196:Agonists:
8052:Ganitumab
7972:IGF-1 LR3
7891:Volitinib
7846:INCB28060
7836:Foretinib
7742:Agonists:
7726:Trafermin
7684:Agonists:
7665:Burosumab
7655:Trafermin
7603:Agonists:
7570:Aprutumab
7560:Trafermin
7522:10 (KGF2)
7470:Agonists:
7447:Trafermin
7427:10 (KGF2)
7387:Agonists:
7317:Agonists:
7263:Agonists:
7245:Tucatinib
7240:Neratinib
7230:Lapatinib
7138:Matuzumab
7128:Futuximab
7113:Cetuximab
7103:WHI-P 154
7088:Neratinib
7083:Lapatinib
7073:Grandinin
7068:Gefitinib
7063:Erlotinib
6940:Agonists:
6900:CE-245677
6862:Agonists:
6648:EC number
2318:Mutations
2256:(SNP) in
2073:receptors
1911:NP_963895
1907:NP_034337
1882:NP_075418
1878:NP_075259
1832:NP_000132
1808:NM_201601
1804:NM_010207
1783:NM_023031
1771:NM_023030
1767:NM_023029
1763:NM_023028
1759:NM_022976
1755:NM_022975
1751:NM_022974
1747:NM_022973
1743:NM_022972
1739:NM_022971
1735:NM_022970
1697:NM_000141
1533:Orthologs
852:cytoplasm
289:GeneCards
9730:instead)
9719:Renalase
9680:instead)
9651:instead)
9598:instead)
9438:Axitinib
9407:D (FIGF)
9351:PLX-7486
9341:ONO-4474
9296:AZD-6918
9250:PLX-7486
9240:ONO-4474
9195:AZD-6918
9177:Ligands:
9095:Deprenyl
9055:7,3'-DHF
8986:MEDI-578
8966:ASP-6294
8930:PLX-7486
8920:ONO-4474
8870:AZD-6918
8830:ALE-0540
8751:instead.
8695:Imatinib
8685:Axitinib
8665:Ancestim
8630:Unsorted
8408:Imatinib
8398:Axitinib
8302:MEDI-578
8282:ASP-6294
8249:ALE-0540
8091:Agonists
8032:AVE-1642
7958:Agonists
7881:SU-11274
7767:Agonists
7745:FGF15/19
7735:Unsorted
7700:2 (bFGF)
7619:2 (bFGF)
7486:2 (bFGF)
7403:2 (bFGF)
7225:Afatinib
7176:Agonists
7078:Icotinib
7038:Afatinib
6984:Agonists
6672:Kinetics
6596:Cofactor
6559:Activity
3526:Proteins
3245:23282194
3237:15622262
3208:12168799
3068:39997577
3060:18773495
2970:20004243
2908:27412585
2900:23696246
2865:17529973
2791:31736768
2742:27191391
2685:11069186
2642:10618369
2388:–
2367:–
2336:See also
2312:toxicity
2304:Alofanib
2275:melanoma
2121:interact
2093:ectoderm
2087:Isoforms
2063:Function
1959:Wikidata
1512:Sources:
857:membrane
628:calvaria
377:10q26.13
9772:Biology
9607:Ephrins
9311:DS-6051
9210:DS-6051
9115:LM22A-4
9105:DMAQ-B1
9060:7,8-DHF
9040:3,7-DHF
9009:RBM-004
8954:GBR-900
8885:DS-6051
8855:VM-902A
8325:RBM-004
8022:OSl-906
7982:Insulin
7861:MK-2461
7806:AMG-458
6943:Axokine
6782:Ligases
6552:Enzymes
5573:2.7.10)
5334:301–350
5128:251–300
5080:CD240CE
4877:201–250
4561:151–200
4284:101–150
3179:8528214
3150:8417497
3115:6471340
3107:7999363
3019:9315632
2856:3493132
2783:8663044
2734:8576175
2693:4418272
2665:Bibcode
2610:Bibcode
2583:8393815
2533:1697263
2484:2172978
2452:Bibcode
2390:Ensembl
2369:Ensembl
2057:isoform
2003:protein
1645:UniProt
1600:Ensembl
1539:Species
1518:QuickGO
867:nucleus
519:pattern
245:Aliases
9758:Portal
9577:Others
9271:BNN-20
9160:ANA-12
9085:BNN-20
8805:DHEA-S
8790:BNN-27
8785:BNN-20
8224:DHEA-S
8209:BNN-27
8204:BNN-20
8120:Others
7325:Epigen
7003:Epigen
6756:Lyases
6490:family
6451:family
6355:family
6326:family
6302:family
6278:family
6254:family
6230:family
6206:family
6145:family
6116:family
6104:AATYK2
6092:family
6057:family
6038:family
6019:family
5995:family
5971:family
5947:family
5923:family
5834:family
5801:family
5777:family
5765:VEGFR3
5760:VEGFR2
5755:VEGFR1
5748:family
5714:family
5701:PDGFRB
5696:PDGFRA
5642:family
5341:CD300A
5300:CDw293
5085:CD240D
4946:CD213a
4924:CDw210
4889:CD202b
4863:CDw199
4858:CDw198
4512:CD140b
3944:51–100
3271:(MeSH)
3243:
3235:
3206:
3177:
3148:
3138:
3113:
3105:
3066:
3058:
3017:
3010:232422
3007:
2968:
2906:
2898:
2863:
2853:
2789:
2781:
2740:
2732:
2691:
2683:
2657:Nature
2640:
2630:
2581:
2531:
2524:551973
2521:
2482:
2472:
2291:FPA144
2258:intron
2244:Cancer
2077:ligand
1991:FGFR-2
1945:search
1943:PubMed
1678:P21803
1659:P21802
1555:Entrez
690:BioGPS
269:176943
9726:(see
9676:(see
9647:(see
9594:(see
9326:K252a
9225:K252a
8900:K252a
8840:FX007
8600:GFRα4
8569:GFRα3
8538:GFRα2
8502:GFRα1
8130:IGFBP
8083:IGF-2
8062:R1507
7950:IGF-1
7856:K252a
7676:FGFR4
7595:FGFR3
7462:FGFR2
7379:FGFR1
6708:Types
6502:ZAP70
6168:STYK1
6133:TYRO3
6099:AATYK
5906:EPHB6
5901:EPHB5
5896:EPHB4
5891:EPHB3
5886:EPHB2
5881:EPHB1
5876:EPHA8
5871:EPHA7
5866:EPHA6
5861:EPHA5
5856:EPHA4
5851:EPHA3
5846:EPHA2
5841:EPHA1
5818:NTRK3
5813:NTRK2
5808:NTRK1
5736:FGFR4
5731:FGFR3
5726:FGFR2
5721:FGFR1
5692:PDGFR
5677:CSF1R
5659:INSRR
5649:IGF1R
5630:ERBB4
5625:ERBB3
5620:ERBB2
5521:CD350
5516:CD349
5511:CD344
5506:CD340
5501:CD339
5496:CD338
5491:CD337
5486:CD336
5481:CD335
5476:CD334
5471:CD333
5466:CD332
5461:CD331
5456:CD329
5451:CD328
5446:CD327
5441:CD326
5436:CD325
5431:CD324
5426:CD322
5421:CD321
5416:CD320
5411:CD318
5406:CD317
5401:CD316
5396:CD315
5391:CD314
5386:CD312
5381:CD309
5376:CD307
5371:CD306
5366:CD305
5361:CD304
5356:CD303
5351:CD302
5346:CD301
5325:CD299
5320:CD298
5315:CD297
5310:CD295
5305:CD294
5295:CD292
5290:CD290
5285:CD289
5280:CD288
5275:CD286
5270:CD284
5265:CD283
5260:CD282
5255:CD281
5250:CD280
5245:CD279
5240:CD278
5235:CD276
5230:CD275
5225:CD274
5220:CD273
5215:CD272
5210:CD271
5205:CD269
5200:CD268
5195:CD267
5190:CD266
5185:CD265
5180:CD264
5175:CD263
5170:CD262
5165:CD261
5160:CD258
5155:CD257
5150:CD256
5145:CD254
5140:CD253
5135:CD252
5119:CD249
5114:CD248
5110:CD247
5105:CD246
5100:CD244
5095:CD243
5090:CD241
5075:CD239
5070:CD238
5065:CD236
5048:CD235
5043:CD234
5038:CD233
5033:CD230
5028:CD229
5023:CD228
5018:CD227
5013:CD226
5008:CD225
5003:CD224
4998:CD223
4993:CD222
4988:CD221
4983:CD220
4968:CD218
4963:CD217
4941:CD212
4919:CD209
4914:CD208
4909:CD207
4904:CD206
4899:CD205
4894:CD204
4884:CD201
4868:CD200
4853:CD197
4848:CD196
4843:CD195
4838:CD194
4833:CD193
4828:CD192
4823:CD191
4818:CD186
4813:CD185
4808:CD184
4803:CD183
4798:CD182
4793:CD181
4788:CD180
4771:CD179
4766:CD178
4761:CD177
4756:CD174
4734:CD172
4729:CD171
4724:CD170
4719:CD169
4714:CD168
4697:CD167
4692:CD166
4687:CD164
4682:CD163
4677:CD162
4672:CD161
4667:CD160
4650:CD159
4620:CD158
4615:CD157
4593:CD156
4588:CD155
4583:CD154
4578:CD153
4573:CD152
4568:CD151
4552:CD150
4547:CD148
4542:CD147
4537:CD146
4532:CD144
4527:CD143
4522:CD142
4517:CD141
4507:CD138
4502:CD137
4497:CD136
4492:CD135
4487:CD134
4482:CD133
4477:CD132
4472:CD131
4467:CD130
4462:CD129
4457:CD127
4452:CD126
4447:CD125
4442:CD124
4437:CD123
4432:CD122
4415:CD121
4398:CD120
4393:CD119
4388:CD118
4383:CD117
4378:CD116
4373:CD115
4368:CD114
4363:CD113
4358:CD112
4353:CD111
4348:CD110
4343:CD109
4338:CD108
4321:CD107
4316:CD106
4311:CD105
4306:CD104
4301:CD103
4296:CD102
4291:CD101
4275:CD100
3288:FGFR2
3276:FGFR2
3241:S2CID
3111:S2CID
3064:S2CID
2946:(PDF)
2904:S2CID
2787:S2CID
2738:S2CID
2689:S2CID
2633:26614
2475:54916
2293:is a
2136:FGF-1
2123:with
2007:FGFR2
1995:CD332
1588:14183
1548:Mouse
1543:Human
1514:Amigo
542:Mouse
535:Human
482:Start
417:Mouse
381:Start
314:Human
293:FGFR2
285:22566
277:95523
252:FGFR2
33:FGFR2
18:FGFR2
9728:here
9678:here
9649:here
9596:here
9391:VEGF
9365:VEGF
9281:NT-3
9276:DHEA
9260:TrkC
9180:DHEA
9150:TDP6
9130:NT-4
9125:NT-3
9110:HIOC
9080:BDNF
9029:TrkB
8800:DHEA
8769:TrkA
8749:here
8747:See
8740:TGFβ
8345:PDGF
8239:NT-4
8234:NT-3
8219:DHEA
8199:BDNF
6948:CNTF
6932:CNTF
6800:list
6793:EC7
6787:list
6780:EC6
6774:list
6767:EC5
6761:list
6754:EC4
6748:list
6741:EC3
6735:list
6728:EC2
6722:list
6715:EC1
6408:YES1
6377:TYK2
6372:JAK3
6367:JAK2
6362:JAK1
6343:SRMS
6290:PYK2
6266:MATK
6242:TNK1
6237:ACK1
6213:ABL1
6080:ROS1
6064:MUSK
6026:PTK7
6007:DDR2
6002:DDR1
5983:ROR2
5978:ROR1
5911:EPHX
5682:FLT3
5654:INSR
5615:EGFR
4270:CD99
4265:CD98
4260:CD97
4255:CD96
4250:CD95
4245:CD94
4240:CD93
4235:CD92
4231:CD91
4226:CD90
4221:CD89
4216:CD88
4211:CD87
4206:CD86
4169:CD85
4164:CD84
4159:CD83
4154:CD82
4149:CD81
4144:CD80
4127:CD79
4122:CD78
4117:CD74
4112:CD73
4107:CD72
4102:CD71
4097:CD70
4092:CD69
4087:CD68
4050:CD66
4028:CD64
4023:CD63
4001:CD62
3996:CD61
3991:CD59
3986:CD58
3981:CD57
3976:CD56
3971:CD55
3966:CD54
3961:CD53
3956:CD52
3951:CD51
3935:CD50
3898:CD49
3893:CD48
3888:CD47
3883:CD46
3878:CD45
3873:CD44
3868:CD43
3841:CD42
3836:CD41
3831:CD40
3826:CD39
3821:CD38
3816:CD37
3811:CD36
3806:CD35
3801:CD34
3796:CD33
3779:CD32
3774:CD31
3769:CD30
3764:CD29
3759:CD28
3754:CD27
3749:CD26
3744:CD25
3739:CD24
3734:CD23
3729:CD22
3724:CD21
3719:CD20
3714:CD19
3709:CD18
3692:CD16
3687:CD15
3682:CD14
3677:CD13
3650:CD11
3645:CD10
3542:1–50
3482:2fdb
3467:1wvz
3452:1oec
3437:1nun
3422:1iil
3407:1ii4
3392:1gjo
3377:1ev2
3362:1e0o
3347:1djs
3233:PMID
3204:PMID
3175:PMID
3146:PMID
3136:ISBN
3103:PMID
3056:PMID
3015:PMID
2966:PMID
2954:1802
2896:PMID
2861:PMID
2779:PMID
2730:PMID
2681:PMID
2638:PMID
2579:PMID
2529:PMID
2480:PMID
2273:and
2265:SNP.
2262:gene
2180:and
2125:FGF1
2079:and
2047:and
2010:gene
1569:2263
525:Bgee
473:Band
434:Chr.
372:Band
331:Chr.
265:OMIM
222:4WV1
218:4J23
214:4J99
210:4J98
206:4J97
202:4J96
198:4J95
194:3RI1
190:3OJM
186:3OJ2
182:3EUU
178:3DAR
174:3CU1
170:3CLY
166:3CAF
162:3B2T
158:2Q0B
154:2PZR
150:2PZP
146:2PZ5
142:2PY3
138:2PWL
134:2PVY
130:2PVF
126:2PSQ
122:2FDB
118:1WVZ
114:1OEC
110:1NUN
106:1IIL
102:1II4
98:1GJO
94:1EV2
90:1E0O
86:1DJS
67:RCSB
64:PDBe
9145:R13
8815:NGF
8760:Trk
8229:NGF
7941:IGF
7801:AM7
7692:FGF
7611:FGF
7512:),
7510:KGF
7478:FGF
7395:FGF
7370:FGF
6972:EGF
6497:SYK
6488:SYK
6478:TXK
6473:ITK
6468:BTK
6463:BMX
6458:TEC
6449:TEC
6439:LYN
6434:LCK
6429:HCK
6424:BLK
6403:FYN
6398:FGR
6393:SRC
6353:JAK
6338:BRK
6333:FRK
6324:FRK
6314:FER
6309:FES
6300:FES
6285:FAK
6276:FAK
6261:CSK
6252:CSK
6228:ACK
6218:ARG
6204:ABL
6152:RET
6128:MER
6123:AXL
6045:RYK
5959:TEK
5954:TIE
5935:ALK
5930:LTK
5789:RON
5784:MET
5687:KIT
3640:CD9
3628:CD8
3623:CD7
3618:CD6
3613:CD5
3608:CD4
3586:CD3
3581:CD2
3554:a-c
3549:CD1
3225:doi
3221:115
3196:doi
3167:doi
3128:doi
3095:doi
3046:doi
3042:238
3005:PMC
2997:doi
2958:doi
2888:doi
2851:PMC
2843:doi
2769:doi
2765:271
2720:doi
2716:271
2673:doi
2661:407
2628:PMC
2618:doi
2571:doi
2567:158
2519:PMC
2511:doi
2470:PMC
2460:doi
2182:-18
2178:-17
2152:-22
2148:-10
495:End
394:End
297:OMA
273:MGI
57:PDB
9784::
9639:B3
9637:,
9635:B2
9633:,
9631:B1
9629:,
9627:A5
9625:,
9623:A4
9621:,
9619:A3
9617:,
9615:A2
9613:,
9611:A1
9405:,
9401:,
9397:,
9140:R7
8956:;
8375:,
8371:,
8367:,
8156:,
8152:,
8148:,
8144:,
8140:,
8136:,
8093::
7960::
7769::
7720:19
7718:,
7714:,
7710:,
7706:,
7702:,
7698:,
7639:23
7637:,
7635:18
7633:,
7629:,
7625:,
7621:,
7617:,
7534:22
7532:,
7530:18
7528:,
7526:17
7524:,
7520:,
7516:,
7504:,
7500:,
7496:,
7492:,
7488:,
7484:,
7431:20
7429:,
7425:,
7421:,
7417:,
7413:,
7409:,
7405:,
7401:,
7353:,
7349:,
7345:,
7341:,
7276:,
7272:,
7178::
6986::
5571:EC
5565::
5112:-
4233:-
3574:1E
3569:1D
3564:1B
3559:1A
3528::
3239:.
3231:.
3219:.
3202:.
3192:17
3190:.
3173:.
3161:.
3144:.
3134:.
3109:.
3101:.
3091:39
3089:.
3062:.
3054:.
3040:.
3036:.
3013:.
3003:.
2993:17
2991:.
2987:.
2964:.
2952:.
2948:.
2902:.
2894:.
2884:34
2882:.
2859:.
2849:.
2839:39
2837:.
2833:.
2807:.
2785:.
2777:.
2763:.
2759:.
2736:.
2728:.
2714:.
2710:.
2687:.
2679:.
2671:.
2659:.
2636:.
2626:.
2616:.
2606:97
2604:.
2600:.
2577:.
2565:.
2527:.
2517:.
2505:.
2501:.
2478:.
2468:.
2458:.
2448:87
2446:.
2442:.
2423:.
2405:.
2376:^
2355:^
2302:.
2277:.
2176:,
2174:-9
2172:,
2170:-8
2168:,
2166:-6
2164:,
2162:-4
2160:,
2158:-2
2150:,
2146:,
2144:-7
2142:,
2140:-3
2138:,
2127:.
2111:.
2059:.
2020:.
1516:/
501:bp
488:bp
400:bp
387:bp
295:;
291::
287:;
283::
279:;
275::
271:;
267::
220:,
216:,
212:,
208:,
204:,
200:,
196:,
192:,
188:,
184:,
180:,
176:,
172:,
168:,
164:,
160:,
156:,
152:,
148:,
144:,
140:,
136:,
132:,
128:,
124:,
120:,
116:,
112:,
108:,
104:,
100:,
96:,
92:,
88:,
9760::
9672:/
9641:)
9609:(
9409:)
9403:C
9399:B
9395:A
9393:(
8942:)
8379:)
8377:D
8373:C
8369:B
8365:A
8363:(
8160:)
8158:7
8154:6
8150:5
8146:4
8142:3
8138:2
8134:1
8132:(
7722:)
7716:9
7712:8
7708:6
7704:4
7696:1
7694:(
7641:)
7631:9
7627:8
7623:4
7615:1
7613:(
7536:)
7518:9
7514:8
7508:(
7506:7
7502:6
7498:5
7494:4
7490:3
7482:1
7480:(
7433:)
7423:8
7419:6
7415:5
7411:4
7407:3
7399:1
7397:(
7357:)
7351:4
7347:3
7343:2
7339:1
7337:(
7280:)
7274:2
7270:1
7268:(
6835:e
6828:t
6821:v
6802:)
6798:(
6789:)
6785:(
6776:)
6772:(
6763:)
6759:(
6750:)
6746:(
6737:)
6733:(
6724:)
6720:(
6544:e
6537:t
6530:v
5703:)
5694:(
5569:(
5555:e
5548:t
5541:v
5058:b
5053:a
4979:)
4977:b
4972:a
4970:(
4956:2
4951:1
4934:b
4929:a
4781:b
4776:a
4749:g
4744:b
4739:a
4707:b
4702:a
4660:c
4655:a
4646:)
4644:k
4639:i
4634:e
4629:d
4624:a
4622:(
4608:c
4603:b
4598:a
4425:b
4420:a
4408:b
4403:a
4331:b
4326:a
4199:k
4194:j
4189:h
4184:e
4179:d
4174:a
4137:b
4132:a
4080:f
4075:e
4070:d
4065:c
4060:b
4055:a
4043:C
4038:B
4033:A
4016:P
4011:L
4006:E
3928:f
3923:e
3918:d
3913:c
3908:b
3903:a
3861:d
3856:c
3851:b
3846:a
3789:B
3784:A
3702:B
3697:A
3670:d
3665:c
3660:b
3655:a
3633:a
3601:ε
3596:δ
3591:γ
3536:)
3518:e
3511:t
3504:v
3322:e
3315:t
3308:v
3295:.
3283:.
3247:.
3227::
3210:.
3198::
3181:.
3169::
3163:4
3152:.
3130::
3117:.
3097::
3070:.
3048::
3021:.
2999::
2972:.
2960::
2910:.
2890::
2867:.
2845::
2817:.
2793:.
2771::
2744:.
2722::
2695:.
2675::
2667::
2644:.
2620::
2612::
2585:.
2573::
2549:.
2535:.
2513::
2507:9
2486:.
2462::
2454::
2427:.
2409:.
2219:)
1997:(
1989:(
419:)
316:)
299::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
