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Erythema multiforme

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The mild form usually presents with mildly itchy (but itching can be very severe), pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7–10 days is the norm.
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Individuals with persistent (chronic) erythema multiforme will often have a lesion form at an injury site, e.g. a minor scratch or abrasion, within a week. Irritation or even pressure from clothing will cause the erythema sore to continue to expand along its margins for weeks or months, long after
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that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life. The disorder has various forms or presentations, which its name reflects
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Erythema multiforme major—typical targets or raised, edematous papules distributed acrally with involvement of one or more mucous membranes; epidermal detachment involves less than 10% of
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in almost all cases. A herpetic etiology also accounts for 55% of cases of EM major. Among the other infections,
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therapy can be uncertain, because it is difficult to determine if the course will be a resolving one.
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Erythema multiforme is frequently self-limiting and requires no treatment. The appropriateness of
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used to be considered part of the erythema multiforme spectrum, but that is no longer the case.
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James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020).
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are a typical manifestation. Two types, one mild to moderate and one severe, are recognized (
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Erythema multiforme minor—typical targets or raised, edematous papules distributed
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Erythema multiforme minor of the hands (note the blanching centers of the lesion)
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Leaute-Labreze C, Lamireau T, Chawki D, Maleville J, Taieb A (October 2000).
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List of human leukocyte antigen alleles associated with cutaneous conditions
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Many suspected etiologic factors have been reported to cause EM.
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Johnstone, Ronald B. (2017). "3. Lichenoid reaction pattern".
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Erythema multiforme was first described by von Hebra in 1860.
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Herpes simplex virus suppression and even prophylaxis (with
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The condition varies from a mild, self-limited rash (
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Andrews' Diseases of the Skin: Clinical Dermatology
986:Diseases of the skin and appendages by morphology 2448: 707: 705: 703: 413:Physical factors: radiotherapy, cold, sunlight 173:) to a severe, life-threatening form known as 2052: 1471:Pityriasis lichenoides et varioliformis acuta 971: 577:(13th ed.). Elsevier. pp. 141–142. 242:Erythema Multiforme target lesions on the leg 1125:Dermatofibroma (benign fibrous histiocytoma) 801: 795: 564: 562: 382:, most commonly to: antibiotics (including, 700: 443:EM minor is regarded as being triggered by 2350:Acute generalized exanthematous pustulosis 2066: 2059: 2045: 978: 964: 56: 2224:Acquired C1 esterase inhibitor deficiency 819: 640: 559: 538: 532: 2462:Herpes simplex virus–associated diseases 451:infection appears to be a common cause. 215:the original sore at the center heals. 14: 2449: 1778:Disseminated intravascular coagulation 802:Yeung AK, Goldman RD (November 2005). 545:(2nd ed.). Elsevier. p. 41. 2277:Episodic angioedema with eosinophilia 2040: 959: 266:Erythema multiforme of head and limbs 164: 117:-bound complexes) in the superficial 781:The Lecturio Medical Concept Library 27:Presence of red patches on the hands 2254:Urticaria-like follicular mucinosis 109:possibly mediated by deposition of 24: 1603: 1560:Postinflammatory hyperpigmentation 680: 542:Weedon's Skin Pathology Essentials 25: 2473: 1461:Transient acantholytic dermatosis 840: 289:Infections: bacterial (including 2161:Localized heat contact urticaria 2138:Secondary cold contact urticaria 1570:Idiopathic guttate hypomelanosis 621:Archives of Disease in Childhood 259: 247: 235: 223: 1580:Hypopigmented mycosis fungoides 769: 2133:Primary cold contact urticaria 1821:Lichen sclerosis et atrophicus 1529:Subcorneal pustular dermatosis 1155:Infantile digital fibromatosis 747: 674: 657: 608: 591: 507: 293:(BCG) vaccination, haemolytic 18:Erythema exudativum multiforme 13: 1: 2407:Necrolytic migratory erythema 2368:Erythema annulare centrifugum 2259:Chronic spontaneous urticaria 1413:Epidermolysis bullosa simplex 1250:Langerhans cell histiocytosis 500: 254:Erythema multiforme of tongue 2099:Urticarial allergic eruption 1889:Systemic lupus erythematosus 1644:Systemic lupus erythematosus 1335:Systemic lupus erythematosus 603:Dorland's Medical Dictionary 461: 7: 2388:Annular erythema of infancy 1170:Lymphangioma circumscriptum 571:"7. Erythema and urticaria" 473: 416:Others: collagen diseases, 102:, typically on both hands. 10: 2478: 2333:Toxic epidermal necrolysis 2194:Delayed pressure urticaria 1992:Mucous membrane pemphigoid 490:Toxic epidermal necrolysis 278: 205:toxic epidermal necrolysis 29: 2432:Necrolytic acral erythema 2396: 2358: 2323:Erythema multiforme major 2318:Erythema multiforme minor 2303: 2294: 2267: 2216: 2174: 2151: 2116: 2107: 2091: 2072: 1955: 1922: 1866: 1851: 1842: 1799: 1770: 1749: 1740: 1693: 1652: 1621: 1610: 1592: 1537: 1479: 1421: 1358: 1278: 1207: 1196: 1187: 1102: 1066: 998: 991: 918: 848: 485:Erythema multiforme minor 480:Erythema multiforme major 274: 181:erythema multiforme majus 176:erythema multiforme major 156:erythema multiforme major 152:erythema multiforme minor 69: 64: 55: 51:Erythema multiforme minor 47: 42: 2328:Stevens–Johnson syndrome 2179:Dermatographic urticaria 1757:Thrombocytopenic purpura 1403:Dermatitis herpetiformis 1388:Acute contact dermatitis 1340:Pityriasis rubra pilaris 1265:Wiskott–Aldrich syndrome 1235:Lichen simplex chronicus 1115:Epidermal inclusion cyst 495:Stevens–Johnson syndrome 406:, antituberculoids, and 291:Bacillus Calmette–GuĂ©rin 201:Stevens–Johnson syndrome 43:Erythema multiforme (EM) 30:Not to be confused with 2383:Erythema gyratum repens 2022:Squamous-cell carcinoma 2017:Systemic histoplasmosis 1408:Porphyria cutanea tarda 1038:Squamous-cell carcinoma 195:total body surface area 2067:Urticaria and erythema 1997:Cicatricial pemphigoid 1914:Acne keloidalis nuchae 1909:Folliculitis decalvans 310:Neisseria meningitidis 98:patches evolving into 2282:Hereditary angioedema 2199:Cholinergic urticaria 2143:Reflex cold urticaria 1899:Loose anagen syndrome 1826:Necrobiosis lipoidica 1762:Actinic/solar purpura 1436:Insect bite reactions 1225:Seborrheic dermatitis 1048:Merkel-cell carcinoma 1028:Molluscum contagiosum 777:"Erythema Multiforme" 755:"Erythema Multiforme" 714:"Erythema multiforme" 598:"erythema multiforme" 340:Mycoplasma pneumoniae 2427:Generalized erythema 2234:Autoimmune urticaria 2229:Adrenergic urticaria 2184:Vibratory angioedema 1722:Annulare centrifugum 1245:Glucagonoma syndrome 1043:Basal-cell carcinoma 1018:Seborrheic keratosis 633:10.1136/adc.83.4.347 422:non-Hodgkin lymphoma 390:), anticonvulsants ( 352:Coccidioides immitis 123:oral mucous membrane 2373:Erythema marginatum 2305:Erythema multiforme 2249:Schnitzler syndrome 2204:Aquagenic urticaria 1967:Aphthous stomatitis 1904:Lichen planopilaris 1879:Androgenic alopecia 1685:Fixed drug eruption 1260:Pemphigus foliaceus 1160:Granular cell tumor 665:Erythema Multiforme 171:E. multiforme minor 84:Erythema multiforme 2244:Galvanic urticaria 2239:Exercise urticaria 2189:Pressure urticaria 2109:Physical urticaria 2092:Allergic urticaria 1987:Pemphigus vulgaris 1816:Granuloma annulare 1680:Carcinoid syndrome 1565:Tuberous sclerosis 1524:Coccidioidomycosis 1398:Bullous pemphigoid 1393:Pemphigus vulgaris 1325:Secondary syphilis 1215:Contact dermatitis 919:External resources 434:myeloid metaplasia 372:Viral (especially 165:Signs and symptoms 94:that appears with 2444: 2443: 2440: 2439: 2360:Figurate erythema 2290: 2289: 2212: 2211: 2034: 2033: 2030: 2029: 1874:Telogen effluvium 1838: 1837: 1834: 1833: 1795: 1794: 1791: 1790: 1736: 1735: 1588: 1587: 1456:Lichen spinulosus 1451:Keratosis pilaris 1330:Mycosis fungoides 1230:Stasis dermatitis 1220:Atopic dermatitis 1183: 1182: 1058:Trichoepithelioma 1033:Actinic keratosis 953: 952: 808:Can Fam Physician 584:978-0-323-54753-6 552:978-0-7020-6830-0 366:Toxoplasma gondii 81: 80: 37:Medical condition 16:(Redirected from 2469: 2412:Erythema toxicum 2378:Erythema migrans 2344:Erythema nodosum 2301: 2300: 2114: 2113: 2089: 2088: 2061: 2054: 2047: 2038: 2037: 1972:Oral candidiasis 1849: 1848: 1747: 1746: 1675:Erythema nodosum 1619: 1618: 1608: 1607: 1601: 1600: 1545:Tinea versicolor 1383:Bullous impetigo 1320:Pityriasis rosea 1255:Lichen sclerosus 1240:Darier's disease 1205: 1204: 1194: 1193: 1150:Kaposi's sarcoma 996: 995: 980: 973: 966: 957: 956: 846: 845: 834: 833: 823: 799: 793: 792: 790: 788: 783:. 7 October 2020 773: 767: 766: 764: 762: 751: 745: 744: 742: 741: 732:. Archived from 718:Am Fam Physician 709: 698: 697: 695: 693: 678: 672: 661: 655: 654: 644: 612: 606: 595: 589: 588: 566: 557: 556: 536: 530: 529: 527: 525: 511: 430:multiple myeloma 410:and many others. 263: 251: 239: 227: 121:of the skin and 119:microvasculature 111:immune complexes 105:It is a type of 60: 40: 39: 32:erythema migrans 21: 2477: 2476: 2472: 2471: 2470: 2468: 2467: 2466: 2447: 2446: 2445: 2436: 2422:Palmar erythema 2392: 2354: 2308: 2286: 2263: 2217:Other urticaria 2208: 2170: 2166:Solar urticaria 2147: 2103: 2076: 2068: 2065: 2035: 2026: 1958: 1951: 1918: 1884:Alopecia areata 1862: 1844: 1830: 1787: 1766: 1742: 1732: 1689: 1648: 1634:Viral exanthems 1612: 1596: 1594: 1584: 1555:Pityriasis alba 1533: 1475: 1417: 1354: 1274: 1270:Zinc deficiency 1200: 1198: 1179: 1107: 1098: 1062: 1053:Nevus sebaceous 987: 984: 954: 949: 948: 914: 913: 857: 843: 838: 837: 800: 796: 786: 784: 775: 774: 770: 760: 758: 757:. Pubmed Health 753: 752: 748: 739: 737: 710: 701: 691: 689: 681:Wetter, David. 679: 675: 662: 658: 613: 609: 596: 592: 585: 567: 560: 553: 537: 533: 523: 521: 519:medlineplus.gov 513: 512: 508: 503: 476: 464: 283: 277: 272: 271: 270: 267: 264: 255: 252: 243: 240: 231: 228: 167: 38: 35: 28: 23: 22: 15: 12: 11: 5: 2475: 2465: 2464: 2459: 2442: 2441: 2438: 2437: 2435: 2434: 2429: 2424: 2419: 2414: 2409: 2403: 2401: 2394: 2393: 2391: 2390: 2385: 2380: 2375: 2370: 2364: 2362: 2356: 2355: 2353: 2352: 2347: 2335: 2330: 2325: 2320: 2314: 2312: 2298: 2292: 2291: 2288: 2287: 2285: 2284: 2279: 2273: 2271: 2265: 2264: 2262: 2261: 2256: 2251: 2246: 2241: 2236: 2231: 2226: 2220: 2218: 2214: 2213: 2210: 2209: 2207: 2206: 2201: 2196: 2191: 2186: 2181: 2175: 2172: 2171: 2169: 2168: 2163: 2158: 2156:Heat urticaria 2152: 2149: 2148: 2146: 2145: 2140: 2135: 2130: 2129: 2128: 2121:Cold urticaria 2117: 2111: 2105: 2104: 2102: 2101: 2095: 2093: 2086: 2070: 2069: 2064: 2063: 2056: 2049: 2041: 2032: 2031: 2028: 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Index

Erythema exudativum multiforme
erythema migrans

Specialty
Dermatology
skin condition
red
target lesions
erythema
immune complexes
IgM
microvasculature
oral mucous membrane
multiform
multi-
formis
Target lesions
erythema multiforme minor
erythema multiforme major
E. multiforme minor
erythema multiforme major
acrally
total body surface area
Stevens–Johnson syndrome
toxic epidermal necrolysis
Target lesion
Erythema Multiforme target lesions on the leg
Erythema multiforme of tongue
Erythema multiforme of head and limbs
List of human leukocyte antigen alleles associated with cutaneous conditions

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