333:
310:
232:
207:
591:
584:
339:
238:
40:
2267:
2282:
1247:"Reverse" signaling is one unique property of ephrin ligands that allows for the transmission of an intracellular signal in ephrin-expressing cells that is distinct from the signal transmitted in Eph receptor-expressing cells. Although the mechanism of "reverse" signaling by ephrin-As is not well understood, it is relatively surprising considering that ephrin-A ligands are attached to the
1393:
Cerretti DP, Copeland NG, Gilbert DJ, Jenkins NA, Kuefer MU, Valentine V, Shapiro DN, Cui X, Morris SW (Sep 1996). "The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17".
1276:
as it provides a mechanism by which migrating axons expressing EphAs would preferentially avoid ephrin A5 expressing cells and possibly migrate towards cells with lower expression of ephrin A5. This mechanism is in fact the same one that mediates the guidance of
66:
1251:
solely by a GPI linkage and unlike ephrin-Bs, lack a potential intracellular signaling domain. Nonetheless, certain ephrin-A ligands are known to initiate reverse signaling cascades like ephrin A5, which has been shown to stimulate the spreading of
1478:
Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB (May 2004). "Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling".
1293:
region of the SC bind to EphAs expressed in RGCs migrating from the temporal retina, inducing growth cone collapse and repelling these RGCs away from the posterior SC towards a region of low ephrin A5 expression in the
346:
245:
1264:
abolished the positive effects of ephrin A5 on growth cone spreading. Additionally, EphA receptors were shown to exert opposite effects on motor neuron growth cones by reducing growth cone size.
2322:
1272:
This finding that ephrin A5 promotes growth cone survival that is opposite of EphA signaling and mediated directly by ephrin A5 reverse signaling has important implications for
4807:
4827:
4817:
2596:
2315:
1260:. Reverse signaling by ephrin A5 was demonstrated to be GPI-dependent as the elimination of all GPI linkages by the application of a phosphatidlyinositol-specific
2972:
1429:
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (Oct 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain".
4802:
2308:
2006:
Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro".
3337:
939:
920:
168:
4572:
2647:
4511:
3688:
2880:
2589:
5471:
3613:
5195:
5108:
5053:
5007:
4952:
4687:
4627:
3628:
3558:
3117:
2715:
2657:
1375:
1357:
5190:
5068:
4967:
4753:
4642:
4442:
4402:
4150:
4069:
3931:
3872:
3834:
3779:
3774:
3764:
3638:
3633:
3603:
3578:
3573:
3563:
3449:
3368:
3307:
3235:
3214:
3199:
3152:
2805:
5290:
5148:
5127:
5083:
5063:
4982:
4962:
4677:
4657:
4637:
4280:
4275:
3608:
3332:
2865:
2662:
2368:
1576:"In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases"
5113:
5103:
5058:
5012:
5002:
4957:
4781:
4748:
4728:
4692:
4682:
4632:
4592:
4064:
4044:
4011:
3892:
3794:
3643:
2582:
1147:
5073:
4972:
4867:
4771:
4723:
4716:
4702:
4647:
4617:
4097:
4087:
4039:
4021:
3950:
3784:
3623:
3568:
1154:
4812:
4502:
1527:"Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains"
4107:
3824:
2564:
1887:"Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis"
1464:
4912:
3092:
2775:
5490:
5440:
5411:
5358:
3845:
3712:
2246:
1744:
1340:
5528:
5169:
5165:
5161:
5157:
2710:
2694:
2477:
63:
3438:
3357:
3224:
3141:
2526:
2462:
1319:
5153:
2373:
2131:"Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion"
332:
4842:
3961:
3521:
3132:
2790:
2734:
2725:
309:
5364:
2472:
1344:
1323:
2266:
5451:
5427:
4567:
4123:
3986:
2541:
2363:
984:
5417:
965:
5461:
3857:
3739:
3729:
1224:
231:
206:
148:
2300:
1965:"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee"
4832:
2546:
1844:"Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation"
2281:
345:
244:
5446:
3272:
338:
237:
5354:
2239:
135:
3538:
3454:
3373:
3240:
3157:
2467:
2447:
2353:
1930:"Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor"
156:
5138:
2885:
2760:
2348:
2045:"Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum"
1130:
1126:
1105:
1079:
1075:
1054:
5422:
5038:
4942:
4562:
3981:
2967:
2605:
2452:
5496:
3693:
2977:
2616:
2332:
1278:
17:
1628:
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development".
5436:
4822:
3754:
3703:
2232:
220:
176:
1805:
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development".
1525:
Marquardt T, Shirasaki R, Ghosh S, Andrews SE, Carter N, Hunter T, Pfaff SL (April 2005).
8:
4577:
3991:
2358:
1290:
1282:
1574:
Drescher U, Kremoser C, Handwerker C, Löschinger J, Noda M, Bonhoeffer F (August 1995).
4255:
2608:
2457:
2112:
2103:
2087:
2069:
2060:
2044:
2031:
1994:
1916:
1873:
1830:
1788:
1763:
1723:
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly".
1653:
1605:
1556:
1504:
180:
2155:
2130:
1981:
1964:
1903:
1886:
1736:
1678:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
718:
713:
708:
703:
698:
693:
688:
683:
678:
662:
657:
652:
647:
642:
637:
632:
4882:
2210:
2201:
2189:
2180:
2160:
2117:
2074:
2023:
2019:
1986:
1951:
1908:
1865:
1860:
1843:
1834:
1822:
1793:
1750:
1740:
1711:
1682:
1645:
1597:
1592:
1575:
1548:
1496:
1446:
1411:
128:
56:
2574:
2035:
1998:
1877:
1560:
1508:
5300:
4432:
2511:
2150:
2142:
2107:
2099:
2064:
2056:
2015:
1976:
1941:
1920:
1898:
1855:
1814:
1783:
1775:
1732:
1703:
1694:
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis".
1674:
1657:
1641:
1637:
1609:
1587:
1538:
1488:
1438:
1403:
425:
356:
300:
255:
160:
1261:
750:
regulation of insulin secretion involved in cellular response to glucose stimulus
400:
184:
1380:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1362:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5486:
5407:
5349:
5043:
4892:
4887:
4001:
3996:
2642:
2632:
2627:
1543:
1526:
501:
5522:
5180:
5093:
5022:
4992:
4927:
4837:
4791:
4667:
4597:
4542:
4531:
4016:
3724:
3407:
3312:
3204:
2340:
1946:
1929:
1273:
1248:
619:
1707:
590:
583:
561:
439:
5506:
5476:
5215:
5205:
5098:
4997:
4852:
4672:
4607:
4522:
4026:
3829:
3668:
3663:
3583:
3533:
3347:
3101:
3082:
3061:
3032:
2755:
2750:
2330:
2164:
2146:
2121:
2078:
1826:
1797:
1779:
1754:
1715:
1552:
1500:
1442:
1407:
1257:
1232:
418:
197:
2027:
1990:
1955:
1912:
1869:
1686:
1649:
1601:
1450:
1415:
1194:
5466:
5432:
5330:
5320:
5315:
5305:
5255:
5078:
4977:
4738:
4652:
4582:
4477:
4240:
4205:
4155:
4118:
4054:
3936:
3867:
3819:
3809:
3804:
3799:
3683:
3678:
3673:
3051:
2962:
2952:
2920:
2915:
2910:
2905:
2895:
2855:
2820:
2551:
2536:
1253:
1029:
1010:
39:
1189:
5285:
5250:
5245:
5235:
5225:
5143:
4932:
4907:
4897:
4743:
4697:
4557:
4383:
4352:
4321:
4290:
4235:
4210:
4190:
4175:
4165:
4059:
3976:
3769:
3749:
3648:
3593:
3588:
3412:
3317:
3302:
3097:
3056:
3028:
2997:
2957:
2860:
2815:
2810:
2785:
2780:
2770:
2683:
2677:
2667:
2531:
2516:
2489:
2005:
1884:
1286:
317:
214:
164:
105:
101:
97:
93:
89:
85:
5310:
5280:
5275:
5270:
5265:
5260:
5240:
5230:
5220:
5210:
4902:
4862:
4758:
4733:
4492:
4487:
4482:
4472:
4467:
4462:
4452:
4373:
4311:
4245:
4225:
4220:
4215:
4200:
4195:
4185:
4180:
4074:
4049:
3814:
3734:
3653:
3598:
3488:
3427:
3417:
3322:
3209:
3007:
3002:
2992:
2900:
2890:
2875:
2850:
2845:
2835:
2830:
2825:
2442:
2088:"Regulation of learning by EphA receptors: a protein targeting study"
1818:
884:
845:
activation of transmembrane receptor protein tyrosine kinase activity
384:
371:
283:
270:
172:
1573:
5481:
5200:
4857:
4457:
4447:
4427:
4170:
4160:
3507:
2987:
2930:
2840:
2800:
2484:
1492:
1295:
1178:
4362:
4331:
4300:
4264:
825:
negative regulation of substrate adhesion-dependent cell spreading
5456:
4877:
4342:
3744:
2705:
2215:
2205:
2194:
2184:
2128:
1210:
996:
951:
869:
865:
638:
transmembrane receptor protein tyrosine kinase activator activity
152:
5369:
5033:
4922:
4847:
4552:
4547:
3971:
3966:
3920:
3916:
3912:
3908:
3904:
3900:
3896:
3548:
3087:
2765:
2383:
2085:
1927:
1841:
1228:
1162:
906:
599:
2224:
1524:
1392:
5401:
5397:
5393:
5389:
5385:
5381:
5377:
5373:
5088:
4987:
4662:
4602:
4416:
4139:
4135:
4131:
4127:
3618:
3482:
3401:
3397:
3296:
3292:
3288:
3284:
3193:
3189:
3040:
2521:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
1428:
1236:
2200:
Overview of all the structural information available in the
2179:
Overview of all the structural information available in the
1764:"Roles of Eph receptors and ephrins in segmental patterning"
1242:
4872:
3478:
3474:
3470:
3466:
3462:
3458:
3393:
3389:
3385:
3381:
3377:
3280:
3276:
3268:
3264:
3260:
3256:
3252:
3248:
3244:
3185:
3181:
3177:
3173:
3169:
3165:
3161:
3113:
3109:
3105:
3071:
3036:
3017:
2504:
2499:
2494:
1217:
835:
cellular response to follicle-stimulating hormone stimulus
1962:
1885:
Gale NW, Holland SJ, Valenzuela DM, et al. (1996).
1477:
805:
positive regulation of peptidyl-tyrosine phosphorylation
408:
1665:
Zhou R (1998). "The Eph family receptors and ligands".
5472:
Pituitary adenylate cyclase-activating peptide (PACAP)
689:
anchored component of external side of plasma membrane
2604:
1842:
Winslow JW, Moran P, Valverde J, et al. (1995).
1627:
573:
1928:
Lackmann M, Mann RJ, Kravets L, et al. (1997).
1761:
1289:
map. High ephrin A5 expression on cells in the
1235:. Ephrin A5 has also been shown to bind to the
1267:
1227:(GPI)-anchored protein of the ephrin-A subclass of
780:
regulation of microtubule cytoskeleton organization
5418:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4276:Glial cell line-derived neurotrophic factor (GDNF)
3929:Cleavage products/derivatives with unknown target:
2042:
1336:
1334:
1332:
1315:
1313:
1311:
2086:Gerlai R, Shinsky N, Shih A, et al. (1999).
355:
254:
139:, AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS, ephrin A5
5520:
5452:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2331:Intercellular signaling peptides and proteins /
2129:Davy A, Gale NW, Murray EW, et al. (2000).
3093:Heparin-binding EGF-like growth factor (HB-EGF)
2776:Heparin-binding EGF-like growth factor (HB-EGF)
1329:
1308:
27:Protein-coding gene in the species Homo sapiens
1520:
1518:
1341:GRCm38: Ensembl release 89: ENSMUSG00000048915
755:positive regulation of protein phosphorylation
5504:Additional growth factor receptor modulators:
2590:
2316:
2240:
765:regulation of actin cytoskeleton organization
3858:Insulin-like growth factor-2 (somatomedin A)
3740:Insulin-like growth factor-2 (somatomedin A)
3730:Insulin-like growth factor-1 (somatomedin C)
1804:
1722:
2369:Transforming growth factor beta superfamily
1693:
1567:
1515:
1471:
1320:GRCh38: Ensembl release 89: ENSG00000184349
785:positive regulation of collateral sprouting
2597:
2583:
2323:
2309:
2247:
2233:
1422:
1386:
2154:
2111:
2068:
1980:
1945:
1902:
1859:
1787:
1591:
1542:
1243:Reverse signaling in growth cone survival
5462:Migration-stimulating factor (MSF; PRG4)
2043:Janis LS, Cassidy RM, Kromer LF (1999).
1768:Philos. Trans. R. Soc. Lond. B Biol. Sci
1762:Xu Q, Mellitzer G, Wilkinson DG (2001).
2791:Transforming growth factor alpha (TGFα)
735:positive regulation of synapse assembly
14:
5521:
5365:Connective tissue growth factor (CTGF)
1664:
5428:Hepatoma-derived growth factor (HDGF)
2578:
2304:
2228:
1457:
810:regulation of focal adhesion assembly
360:
321:
316:
259:
218:
213:
2478:Nephroblastoma overexpressed protein
2275:: EphB2 / EphrinA5 Complex Structure
1727:. International Review of Cytology.
2527:Parathyroid hormone-related protein
2463:CCN intercellular signaling protein
1231:that binds to the EphA subclass of
830:retinal ganglion cell axon guidance
24:
2374:Vascular endothelial growth factor
2104:10.1523/JNEUROSCI.19-21-09538.1999
2061:10.1523/JNEUROSCI.19-12-04962.1999
1620:
795:multicellular organism development
658:neurotrophin TRKB receptor binding
643:neurotrophin TRKA receptor binding
633:neurotrophin TRKC receptor binding
25:
5540:
2173:
1963:Ephnomenclaturecommittee (1997).
1213:that in humans is encoded by the
775:ephrin receptor signaling pathway
5447:Leukemia inhibitory factor (LIF)
2280:
2265:
2020:10.1046/j.1460-9568.1998.00180.x
1268:Formation of the retinotopic map
815:regulation of cell morphogenesis
800:regulation of cell-cell adhesion
589:
582:
344:
337:
331:
308:
243:
236:
230:
205:
38:
4615:Negative allosteric modulators:
2473:Connective tissue growth factor
2254:
4933:Gossypetin (3,5,7,8,3',4'-HHF)
4124:Platelet-derived growth factor
2565:extracellular ligand disorders
2542:Tolloid-like metalloproteinase
2364:Platelet-derived growth factor
1642:10.1146/annurev.neuro.21.1.309
1465:"Entrez Gene: EFNA5 ephrin-A5"
1368:
1350:
840:cellular response to forskolin
699:anchored component of membrane
600:More reference expression data
562:More reference expression data
13:
1:
5139:Placental growth factor (PGF)
1982:10.1016/S0092-8674(00)80500-0
1904:10.1016/S0896-6273(00)80276-7
1737:10.1016/S0074-7696(00)96005-4
1679:10.1016/S0163-7258(97)00112-5
1301:
770:regulation of GTPase activity
329:
228:
5423:Glia maturation factor (GMF)
3932:Glypromate (GPE, (1-3)IGF-1)
2290:: Ephrin A5 ligand structure
1861:10.1016/0896-6273(95)90335-6
1593:10.1016/0092-8674(95)90425-5
1285:during the formation of the
1256:in cultures of mouse spinal
1225:glycosylphosphatidylinositol
7:
5529:Genes on human chromosome 5
1281:to distinct regions in the
10:
5545:
5355:Colony-stimulating factors
5347:Additional growth factors:
1544:10.1016/j.cell.2005.01.020
855:synaptic membrane adhesion
790:nervous system development
512:superior cervical ganglion
5339:
5126:
5021:
4790:
4703:SNA-120 (pegylated K252a)
4530:
4521:
4501:
4415:
4392:
4361:
4330:
4299:
4263:
4254:
4106:
3949:
3882:
3875:(against IGF-1 and IGF-2)
3844:
3837:(against IGF-1 and IGF-2)
3711:
3702:
3520:
3497:
3437:
3356:
3223:
3140:
3131:
3070:
3016:
2929:
2733:
2724:
2693:
2615:
2560:
2435:
2382:
2339:
2260:
2214:(Mouse Ephrin-A5) at the
2193:(Human Ephrin-A5) at the
1376:"Mouse PubMed Reference:"
1358:"Human PubMed Reference:"
1193:
1188:
1184:
1177:
1161:
1148:Chr 5: 107.38 – 107.67 Mb
1142:
1123:
1119:
1102:
1098:
1091:
1072:
1068:
1051:
1047:
1040:
1027:
1023:
1008:
1004:
995:
982:
978:
963:
959:
950:
937:
933:
918:
914:
905:
890:
883:
879:
863:
618:
614:
597:
581:
572:
559:
508:
499:
446:
437:
407:
399:
395:
378:
365:
328:
307:
298:
294:
277:
264:
227:
204:
195:
191:
146:
143:
133:
126:
121:
82:
77:
60:
55:
50:
46:
37:
32:
3539:Hepatocyte growth factor
3098:Neuregulins (heregulins)
3029:Neuregulins (heregulins)
2973:Trastuzumab duocarmazine
2686:(against angiopoietin 2)
2680:(against angiopoietin 3)
2468:Cysteine-rich protein 61
2448:Agouti signaling protein
2354:Fibroblast growth factor
1947:10.1074/jbc.272.26.16521
1155:Chr 17: 62.91 – 63.19 Mb
362:17 E1.1|17 32.57 cM
2886:Depatuxizumab mafodotin
2349:Epidermal growth factor
1708:10.1242/dev.126.10.2033
653:chemorepellent activity
648:ephrin receptor binding
528:internal carotid artery
520:external carotid artery
5509:(neurotrophin mixture)
5497:Wnt signaling proteins
5178:Allosteric modulators:
4898:Norwogonin (5,7,8-THF)
3118:5 (tomoregulin, TMEFF)
2968:Trastuzumab deruxtecan
2606:Growth factor receptor
2453:Agouti-related protein
2147:10.1101/gad.13.23.3125
1780:10.1098/rstb.2000.0635
1443:10.1006/cyto.1997.0199
1408:10.1006/geno.1996.0371
1279:retinal ganglion cells
486:pancreatic ductal cell
5437:T-cell growth factors
3694:Telisotuzumab vedotin
2978:Trastuzumab emtansine
2547:Tumor necrosis factor
548:epithelium of stomach
462:primary visual cortex
458:middle temporal gyrus
323:Chromosome 17 (mouse)
4022:EVT-901 (SAR-127963)
3755:Mecasermin rinfabate
1223:Ephrin A5 is a
820:collateral sprouting
745:cell differentiation
221:Chromosome 5 (human)
78:List of PDB id codes
51:Available structures
2359:Nerve growth factor
1630:Annu. Rev. Neurosci
1283:superior colliculus
760:negative chemotaxis
466:germinal epithelium
5188:Kinase inhibitors:
5051:Kinase inhibitors:
4950:Kinase inhibitors:
4625:Kinase inhibitors:
4440:Kinase inhibitors:
4400:Kinase inhibitors:
4381:Kinase inhibitors:
4350:Kinase inhibitors:
4319:Kinase inhibitors:
4288:Kinase inhibitors:
4148:Kinase inhibitors:
3762:Kinase inhibitors:
3556:Kinase inhibitors:
3345:Kinase inhibitors:
3338:Aprutumab ixadotin
2985:Kinase inhibitors:
2798:Kinase inhibitors:
2655:Kinase inhibitors:
2458:Angiogenic protein
1807:Nat. Rev. Neurosci
1774:(1399): 993–1002.
985:ENSMUSG00000048915
728:Biological process
719:GABA-ergic synapse
672:Cellular component
626:Molecular function
544:epithelium of lens
5516:
5515:
5122:
5121:
4883:N-Acetylserotonin
4782:ReN-1820 (TrkAd5)
4411:
4410:
3945:
3944:
3890:Binding proteins:
3549:Dihexa (PNB-0408)
3516:
3515:
3127:
3126:
3041:6 (neuroglycan C)
2761:EGF (urogastrone)
2739:
2572:
2571:
2298:
2297:
1746:978-0-12-364600-2
1204:
1203:
1200:
1199:
1173:
1172:
1138:
1137:
1113:
1112:
1087:
1086:
1062:
1061:
1036:
1035:
1017:
1016:
991:
990:
972:
971:
946:
945:
927:
926:
875:
874:
740:apoptotic process
709:adherens junction
704:basement membrane
610:
609:
606:
605:
568:
567:
555:
554:
493:
492:
391:
390:
290:
289:
185:EFNA5 - orthologs
117:
116:
113:
112:
61:Ortholog search:
16:(Redirected from
5536:
5328:Decoy receptors:
5301:Alacizumab pegol
4779:Decoy receptors:
4528:
4527:
4433:Stem cell factor
4374:Persephin (PSPN)
4312:Neurturin (NRTN)
4261:
4260:
4098:LEVI-04 (p75-Fc)
4095:Decoy receptors:
3709:
3708:
3138:
3137:
2737:
2731:
2730:
2599:
2592:
2585:
2576:
2575:
2512:Hedgehog protein
2325:
2318:
2311:
2302:
2301:
2284:
2269:
2249:
2242:
2235:
2226:
2225:
2168:
2158:
2125:
2115:
2082:
2072:
2039:
2008:Eur. J. Neurosci
2002:
1984:
1959:
1949:
1940:(26): 16521–30.
1924:
1906:
1881:
1863:
1838:
1819:10.1038/35058515
1801:
1791:
1758:
1719:
1690:
1661:
1614:
1613:
1595:
1571:
1565:
1564:
1546:
1522:
1513:
1512:
1475:
1469:
1468:
1461:
1455:
1454:
1426:
1420:
1419:
1390:
1384:
1383:
1372:
1366:
1365:
1354:
1348:
1338:
1327:
1317:
1186:
1185:
1157:
1150:
1133:
1117:
1116:
1108:
1096:
1095:
1092:RefSeq (protein)
1082:
1066:
1065:
1057:
1045:
1044:
1021:
1020:
1002:
1001:
976:
975:
957:
956:
931:
930:
912:
911:
881:
880:
616:
615:
602:
593:
586:
579:
578:
564:
504:
502:Top expressed in
497:
496:
482:endothelial cell
454:Brodmann area 23
442:
440:Top expressed in
435:
434:
414:
413:
397:
396:
387:
374:
363:
348:
341:
335:
324:
312:
296:
295:
286:
273:
262:
247:
240:
234:
223:
209:
193:
192:
187:
138:
131:
108:
75:
74:
69:
48:
47:
42:
30:
29:
21:
5544:
5543:
5539:
5538:
5537:
5535:
5534:
5533:
5519:
5518:
5517:
5512:
5457:Midkine (NEGF2)
5335:
5118:
5017:
4786:
4724:ABT-110 (PG110)
4517:
4497:
4407:
4388:
4357:
4326:
4295:
4250:
4102:
4040:ABT-110 (PG110)
3941:
3878:
3840:
3698:
3512:
3493:
3433:
3430:(against FGF23)
3352:
3219:
3123:
3066:
3012:
2925:
2736:
2720:
2689:
2611:
2603:
2573:
2568:
2556:
2431:
2378:
2335:
2329:
2299:
2294:
2291:
2285:
2276:
2270:
2256:
2253:
2222:
2176:
2171:
2141:(23): 3125–35.
2098:(21): 9538–49.
2055:(12): 4962–71.
1747:
1725:Int. Rev. Cytol
1702:(10): 2033–44.
1667:Pharmacol. Ther
1623:
1621:Further reading
1618:
1617:
1572:
1568:
1523:
1516:
1476:
1472:
1463:
1462:
1458:
1427:
1423:
1391:
1387:
1374:
1373:
1369:
1356:
1355:
1351:
1339:
1330:
1318:
1309:
1304:
1270:
1262:phospholipase C
1245:
1195:View/Edit Mouse
1190:View/Edit Human
1153:
1146:
1143:Location (UCSC)
1129:
1125:
1104:
1078:
1074:
1053:
966:ENSG00000184349
859:
723:
684:plasma membrane
667:
663:protein binding
598:
588:
587:
560:
551:
546:
542:
538:
536:arcuate nucleus
534:
530:
526:
522:
518:
514:
500:
489:
484:
480:
476:
474:parietal pleura
472:
468:
464:
460:
456:
452:
438:
382:
369:
361:
351:
350:
349:
342:
322:
299:Gene location (
281:
268:
260:
250:
249:
248:
241:
219:
196:Gene location (
147:
134:
127:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5542:
5532:
5531:
5514:
5513:
5511:
5510:
5500:
5499:
5494:
5487:Thrombopoietin
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5430:
5425:
5420:
5415:
5408:Erythropoietin
5405:
5367:
5362:
5352:
5350:Adrenomedullin
5343:
5341:
5337:
5336:
5334:
5333:
5324:
5323:
5318:
5313:
5308:
5303:
5294:
5293:
5288:
5283:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5193:
5184:
5183:
5174:
5173:
5151:
5146:
5141:
5132:
5130:
5124:
5123:
5120:
5119:
5117:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5047:
5046:
5041:
5036:
5027:
5025:
5019:
5018:
5016:
5015:
5010:
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4946:
4945:
4936:
4935:
4930:
4925:
4916:
4915:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4813:4'-DMA-7,8-DHF
4810:
4805:
4796:
4794:
4788:
4787:
4785:
4784:
4775:
4774:
4762:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4707:
4706:
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4621:
4620:
4611:
4610:
4605:
4600:
4595:
4586:
4585:
4580:
4575:
4573:Gambogic amide
4570:
4565:
4560:
4555:
4550:
4545:
4536:
4534:
4525:
4519:
4518:
4516:
4515:
4507:
4505:
4499:
4498:
4496:
4495:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4436:
4435:
4430:
4421:
4419:
4413:
4412:
4409:
4408:
4406:
4405:
4396:
4394:
4390:
4389:
4387:
4386:
4377:
4376:
4367:
4365:
4359:
4358:
4356:
4355:
4346:
4345:
4343:Artemin (ARTN)
4336:
4334:
4328:
4327:
4325:
4324:
4315:
4314:
4305:
4303:
4297:
4296:
4294:
4293:
4284:
4283:
4278:
4269:
4267:
4258:
4252:
4251:
4249:
4248:
4243:
4238:
4229:
4228:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4153:
4144:
4143:
4121:
4112:
4110:
4104:
4103:
4101:
4100:
4091:
4090:
4078:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4030:
4029:
4024:
4019:
4014:
4005:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3964:
3955:
3953:
3947:
3946:
3943:
3942:
3940:
3939:
3934:
3925:
3924:
3886:
3884:
3880:
3879:
3877:
3876:
3870:
3861:
3860:
3850:
3848:
3842:
3841:
3839:
3838:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3788:
3787:
3782:
3777:
3772:
3767:
3758:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3717:
3715:
3706:
3700:
3699:
3697:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3657:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3552:
3551:
3542:
3541:
3536:
3526:
3524:
3518:
3517:
3514:
3513:
3511:
3510:
3501:
3499:
3495:
3494:
3492:
3491:
3486:
3452:
3443:
3441:
3435:
3434:
3432:
3431:
3421:
3420:
3415:
3410:
3405:
3371:
3362:
3360:
3354:
3353:
3351:
3350:
3341:
3340:
3335:
3326:
3325:
3320:
3315:
3310:
3305:
3300:
3238:
3229:
3227:
3221:
3220:
3218:
3217:
3212:
3207:
3202:
3197:
3155:
3146:
3144:
3135:
3129:
3128:
3125:
3124:
3122:
3121:
3095:
3090:
3085:
3076:
3074:
3068:
3067:
3065:
3064:
3059:
3054:
3045:
3044:
3022:
3020:
3014:
3013:
3011:
3010:
3005:
3000:
2995:
2990:
2981:
2980:
2975:
2970:
2965:
2960:
2955:
2946:
2945:
2935:
2933:
2927:
2926:
2924:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2869:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2794:
2793:
2788:
2783:
2778:
2773:
2768:
2763:
2758:
2753:
2743:
2741:
2728:
2722:
2721:
2719:
2718:
2713:
2708:
2699:
2697:
2691:
2690:
2688:
2687:
2681:
2671:
2670:
2665:
2660:
2651:
2650:
2648:Angiopoietin 3
2645:
2643:Angiopoietin 2
2636:
2635:
2633:Angiopoietin 4
2630:
2628:Angiopoietin 1
2621:
2619:
2613:
2612:
2602:
2601:
2594:
2587:
2579:
2570:
2569:
2561:
2558:
2557:
2555:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2508:
2507:
2502:
2497:
2487:
2482:
2481:
2480:
2475:
2470:
2460:
2455:
2450:
2445:
2439:
2437:
2433:
2432:
2430:
2429:
2424:
2419:
2414:
2409:
2404:
2399:
2394:
2388:
2386:
2380:
2379:
2377:
2376:
2371:
2366:
2361:
2356:
2351:
2345:
2343:
2341:Growth factors
2337:
2336:
2328:
2327:
2320:
2313:
2305:
2296:
2295:
2293:
2292:
2286:
2279:
2277:
2271:
2264:
2261:
2258:
2257:
2252:
2251:
2244:
2237:
2229:
2220:
2219:
2198:
2175:
2174:External links
2172:
2170:
2169:
2126:
2083:
2040:
2014:(5): 1574–80.
2003:
1960:
1925:
1882:
1839:
1802:
1759:
1745:
1720:
1691:
1662:
1624:
1622:
1619:
1616:
1615:
1566:
1514:
1493:10.1038/nn1237
1470:
1456:
1421:
1385:
1367:
1349:
1328:
1306:
1305:
1303:
1300:
1269:
1266:
1244:
1241:
1229:ephrin ligands
1207:Ephrin A5
1202:
1201:
1198:
1197:
1192:
1182:
1181:
1175:
1174:
1171:
1170:
1168:
1166:
1159:
1158:
1151:
1144:
1140:
1139:
1136:
1135:
1121:
1120:
1114:
1111:
1110:
1100:
1099:
1093:
1089:
1088:
1085:
1084:
1070:
1069:
1063:
1060:
1059:
1049:
1048:
1042:
1038:
1037:
1034:
1033:
1025:
1024:
1018:
1015:
1014:
1006:
1005:
999:
993:
992:
989:
988:
980:
979:
973:
970:
969:
961:
960:
954:
948:
947:
944:
943:
935:
934:
928:
925:
924:
916:
915:
909:
903:
902:
897:
892:
888:
887:
877:
876:
873:
872:
861:
860:
858:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
731:
729:
725:
724:
722:
721:
716:
714:cell periphery
711:
706:
701:
696:
691:
686:
681:
675:
673:
669:
668:
666:
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
612:
611:
608:
607:
604:
603:
595:
594:
576:
570:
569:
566:
565:
557:
556:
553:
552:
550:
549:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
506:
505:
494:
491:
490:
488:
487:
483:
479:
475:
471:
470:synovial joint
467:
463:
459:
455:
451:
447:
444:
443:
431:
430:
422:
411:
405:
404:
401:RNA expression
393:
392:
389:
388:
380:
376:
375:
367:
364:
359:
353:
352:
343:
336:
330:
326:
325:
320:
314:
313:
305:
304:
292:
291:
288:
287:
279:
275:
274:
266:
263:
258:
252:
251:
242:
235:
229:
225:
224:
217:
211:
210:
202:
201:
189:
188:
145:
141:
140:
132:
124:
123:
119:
118:
115:
114:
111:
110:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
9:
6:
4:
3:
2:
5541:
5530:
5527:
5526:
5524:
5508:
5505:
5502:
5501:
5498:
5495:
5492:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5442:
5438:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5413:
5409:
5406:
5403:
5399:
5395:
5391:
5387:
5383:
5379:
5375:
5371:
5368:
5366:
5363:
5360:
5356:
5353:
5351:
5348:
5345:
5344:
5342:
5338:
5332:
5329:
5326:
5325:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5296:
5295:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5186:
5185:
5182:
5181:Cyclotraxin B
5179:
5176:
5175:
5171:
5167:
5163:
5159:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5134:
5133:
5131:
5129:
5125:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5094:Larotrectinib
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5049:
5048:
5045:
5042:
5040:
5037:
5035:
5032:
5029:
5028:
5026:
5024:
5020:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4993:Larotrectinib
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4948:
4947:
4944:
4941:
4938:
4937:
4934:
4931:
4929:
4928:Cyclotraxin B
4926:
4924:
4921:
4918:
4917:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4838:Amitriptyline
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4804:
4801:
4798:
4797:
4795:
4793:
4789:
4783:
4780:
4777:
4776:
4773:
4770:
4767:
4764:
4763:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4718:
4715:
4714:Against TrkA:
4712:
4709:
4708:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4668:Larotrectinib
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4623:
4622:
4619:
4616:
4613:
4612:
4609:
4606:
4604:
4601:
4599:
4598:Dexamethasone
4596:
4594:
4591:
4588:
4587:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4543:Amitriptyline
4541:
4538:
4537:
4535:
4533:
4529:
4526:
4524:
4520:
4513:
4509:
4508:
4506:
4504:
4500:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4438:
4437:
4434:
4431:
4429:
4426:
4423:
4422:
4420:
4418:
4414:
4404:
4401:
4398:
4397:
4395:
4391:
4385:
4382:
4379:
4378:
4375:
4372:
4369:
4368:
4366:
4364:
4360:
4354:
4351:
4348:
4347:
4344:
4341:
4338:
4337:
4335:
4333:
4329:
4323:
4320:
4317:
4316:
4313:
4310:
4307:
4306:
4304:
4302:
4298:
4292:
4289:
4286:
4285:
4282:
4279:
4277:
4274:
4271:
4270:
4268:
4266:
4262:
4259:
4257:
4253:
4247:
4244:
4242:
4239:
4237:
4234:
4231:
4230:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4146:
4145:
4141:
4137:
4133:
4129:
4125:
4122:
4120:
4117:
4114:
4113:
4111:
4109:
4105:
4099:
4096:
4093:
4092:
4089:
4086:
4083:
4080:
4079:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4035:
4032:
4031:
4028:
4025:
4023:
4020:
4018:
4017:Dexamethasone
4015:
4013:
4010:
4007:
4006:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3957:
3956:
3954:
3952:
3948:
3938:
3935:
3933:
3930:
3927:
3926:
3922:
3918:
3914:
3910:
3906:
3902:
3898:
3894:
3891:
3888:
3887:
3885:
3881:
3874:
3871:
3869:
3866:
3863:
3862:
3859:
3855:
3852:
3851:
3849:
3847:
3843:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3790:
3789:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3760:
3759:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3725:des(1-3)IGF-1
3722:
3719:
3718:
3716:
3714:
3710:
3707:
3705:
3701:
3695:
3692:
3690:
3689:Telisotuzumab
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3659:
3658:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3554:
3553:
3550:
3547:
3546:Potentiators:
3544:
3543:
3540:
3537:
3535:
3531:
3528:
3527:
3525:
3523:
3519:
3509:
3506:
3503:
3502:
3500:
3496:
3490:
3487:
3484:
3480:
3476:
3472:
3468:
3464:
3460:
3456:
3453:
3451:
3448:
3445:
3444:
3442:
3440:
3436:
3429:
3426:
3423:
3422:
3419:
3416:
3414:
3411:
3409:
3408:Selpercatinib
3406:
3403:
3399:
3395:
3391:
3387:
3383:
3379:
3375:
3372:
3370:
3367:
3364:
3363:
3361:
3359:
3355:
3349:
3346:
3343:
3342:
3339:
3336:
3334:
3331:
3328:
3327:
3324:
3321:
3319:
3316:
3314:
3313:Selpercatinib
3311:
3309:
3306:
3304:
3301:
3298:
3294:
3290:
3286:
3282:
3278:
3274:
3270:
3266:
3262:
3258:
3254:
3250:
3246:
3242:
3239:
3237:
3234:
3231:
3230:
3228:
3226:
3222:
3216:
3213:
3211:
3208:
3206:
3205:Selpercatinib
3203:
3201:
3198:
3195:
3191:
3187:
3183:
3179:
3175:
3171:
3167:
3163:
3159:
3156:
3154:
3151:
3148:
3147:
3145:
3143:
3139:
3136:
3134:
3130:
3119:
3115:
3111:
3107:
3103:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3078:
3077:
3075:
3073:
3069:
3063:
3060:
3058:
3055:
3053:
3050:
3047:
3046:
3042:
3038:
3034:
3030:
3027:
3024:
3023:
3021:
3019:
3015:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2983:
2982:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2948:
2947:
2944:
2940:
2937:
2936:
2934:
2932:
2928:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2881:Depatuxizumab
2879:
2877:
2874:
2871:
2870:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2796:
2795:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2748:
2745:
2744:
2742:
2740:
2732:
2729:
2727:
2723:
2717:
2714:
2712:
2709:
2707:
2704:
2701:
2700:
2698:
2696:
2692:
2685:
2682:
2679:
2676:
2673:
2672:
2669:
2666:
2664:
2661:
2659:
2656:
2653:
2652:
2649:
2646:
2644:
2641:
2638:
2637:
2634:
2631:
2629:
2626:
2623:
2622:
2620:
2618:
2614:
2610:
2607:
2600:
2595:
2593:
2588:
2586:
2581:
2580:
2577:
2567:
2566:
2559:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2506:
2503:
2501:
2498:
2496:
2493:
2492:
2491:
2488:
2486:
2483:
2479:
2476:
2474:
2471:
2469:
2466:
2465:
2464:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2444:
2441:
2440:
2438:
2434:
2428:
2425:
2423:
2420:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2389:
2387:
2385:
2381:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2346:
2344:
2342:
2338:
2334:
2326:
2321:
2319:
2314:
2312:
2307:
2306:
2303:
2289:
2283:
2278:
2274:
2268:
2263:
2262:
2259:
2250:
2245:
2243:
2238:
2236:
2231:
2230:
2227:
2223:
2217:
2213:
2212:
2207:
2203:
2199:
2196:
2192:
2191:
2186:
2182:
2178:
2177:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2127:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2071:
2066:
2062:
2058:
2054:
2050:
2046:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2009:
2004:
2000:
1996:
1992:
1988:
1983:
1978:
1974:
1970:
1966:
1961:
1957:
1953:
1948:
1943:
1939:
1935:
1934:J. Biol. Chem
1931:
1926:
1922:
1918:
1914:
1910:
1905:
1900:
1896:
1892:
1888:
1883:
1879:
1875:
1871:
1867:
1862:
1857:
1854:(5): 973–81.
1853:
1849:
1845:
1840:
1836:
1832:
1828:
1824:
1820:
1816:
1813:(3): 155–64.
1812:
1808:
1803:
1799:
1795:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1760:
1756:
1752:
1748:
1742:
1738:
1734:
1730:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1692:
1688:
1684:
1680:
1676:
1673:(3): 151–81.
1672:
1668:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1631:
1626:
1625:
1611:
1607:
1603:
1599:
1594:
1589:
1586:(3): 359–70.
1585:
1581:
1577:
1570:
1562:
1558:
1554:
1550:
1545:
1540:
1537:(1): 127–39.
1536:
1532:
1528:
1521:
1519:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1481:Nat. Neurosci
1474:
1466:
1460:
1452:
1448:
1444:
1440:
1436:
1432:
1425:
1417:
1413:
1409:
1405:
1401:
1397:
1389:
1381:
1377:
1371:
1363:
1359:
1353:
1346:
1342:
1337:
1335:
1333:
1325:
1321:
1316:
1314:
1312:
1307:
1299:
1297:
1292:
1288:
1284:
1280:
1275:
1274:axon guidance
1265:
1263:
1259:
1258:motor neurons
1255:
1250:
1249:cell membrane
1240:
1238:
1234:
1233:Eph receptors
1230:
1226:
1221:
1219:
1216:
1212:
1208:
1196:
1191:
1187:
1183:
1180:
1176:
1169:
1167:
1164:
1160:
1156:
1152:
1149:
1145:
1141:
1134:
1132:
1128:
1122:
1118:
1115:
1109:
1107:
1101:
1097:
1094:
1090:
1083:
1081:
1077:
1071:
1067:
1064:
1058:
1056:
1050:
1046:
1043:
1041:RefSeq (mRNA)
1039:
1032:
1031:
1026:
1022:
1019:
1013:
1012:
1007:
1003:
1000:
998:
994:
987:
986:
981:
977:
974:
968:
967:
962:
958:
955:
953:
949:
942:
941:
936:
932:
929:
923:
922:
917:
913:
910:
908:
904:
901:
898:
896:
893:
889:
886:
882:
878:
871:
867:
862:
856:
853:
851:
850:axon guidance
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
732:
730:
727:
726:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
621:
620:Gene ontology
617:
613:
601:
596:
592:
585:
580:
577:
575:
571:
563:
558:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
510:
507:
503:
498:
495:
485:
481:
477:
473:
469:
465:
461:
457:
453:
450:hair follicle
449:
448:
445:
441:
436:
433:
432:
429:
427:
423:
421:
420:
416:
415:
412:
410:
406:
402:
398:
394:
386:
381:
377:
373:
368:
358:
354:
347:
340:
334:
327:
319:
315:
311:
306:
302:
297:
293:
285:
280:
276:
272:
267:
257:
253:
246:
239:
233:
226:
222:
216:
212:
208:
203:
199:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
142:
137:
130:
125:
120:
109:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
5507:Cerebrolysin
5503:
5477:Pleiotrophin
5433:Interleukins
5346:
5327:
5297:
5216:Fruquintinib
5206:Cabozantinib
5187:
5177:
5135:
5099:Lestaurtinib
5050:
5030:
4998:Lestaurtinib
4949:
4939:
4920:Antagonists:
4919:
4853:Deoxygedunin
4808:3,7,8,2'-THF
4799:
4778:
4769:Against NGF:
4768:
4765:
4721:Against NGF:
4720:
4713:
4710:
4673:Lestaurtinib
4624:
4614:
4608:Testosterone
4590:Antagonists:
4589:
4539:
4439:
4424:
4399:
4380:
4370:
4349:
4339:
4318:
4308:
4287:
4272:
4232:
4147:
4115:
4094:
4085:Against NGF:
4084:
4081:
4037:Against NGF:
4036:
4033:
4027:Testosterone
4009:Antagonists:
4008:
3958:
3928:
3889:
3864:
3853:
3830:Teprotumumab
3791:
3761:
3720:
3669:Ficlatuzumab
3664:Emibetuzumab
3660:
3614:JNJ-38877605
3584:Cabozantinib
3555:
3545:
3534:Fosgonimeton
3529:
3504:
3446:
3424:
3365:
3348:Infigratinib
3344:
3329:
3232:
3149:
3083:Betacellulin
3079:
3062:Seribantumab
3048:
3025:
2984:
2949:
2943:Unknown/none
2942:
2938:
2872:
2797:
2756:Betacellulin
2751:Amphiregulin
2746:
2738:(ErbB1/HER1)
2702:
2674:
2654:
2640:Antagonists:
2639:
2624:
2617:Angiopoietin
2562:
2287:
2272:
2221:
2209:
2188:
2138:
2134:
2095:
2091:
2052:
2048:
2011:
2007:
1975:(3): 403–4.
1972:
1968:
1937:
1933:
1894:
1890:
1851:
1847:
1810:
1806:
1771:
1767:
1728:
1724:
1699:
1695:
1670:
1666:
1633:
1629:
1583:
1579:
1569:
1534:
1530:
1487:(5): 501–9.
1484:
1480:
1473:
1459:
1437:(8): 540–9.
1434:
1430:
1424:
1402:(2): 376–9.
1399:
1395:
1388:
1379:
1370:
1361:
1352:
1271:
1254:growth cones
1246:
1222:
1214:
1206:
1205:
1124:
1103:
1073:
1052:
1028:
1009:
983:
964:
938:
919:
899:
894:
524:ciliary body
424:
417:
282:107,670,937
269:107,376,894
144:External IDs
83:
5467:Oncomodulin
5331:Aflibercept
5321:Ranibizumab
5316:Ramucirumab
5306:Bevacizumab
5298:Antibodies:
5256:Regorafenib
5196:Altiratinib
5109:ONO-5390556
5079:Entrectinib
5054:Altiratinib
5008:ONO-5390556
4978:Entrectinib
4953:Altiratinib
4739:Frunevetmab
4711:Antibodies:
4688:ONO-5390556
4653:Entrectinib
4628:Altiratinib
4583:Tavilermide
4478:Quizartinib
4417:SCF (c-Kit)
4241:Ramucirumab
4233:Antibodies:
4206:Quizartinib
4156:Avapritinib
4119:Becaplermin
4055:Frunevetmab
4034:Antibodies:
3937:Trofinetide
3868:Dusigitumab
3865:Antibodies:
3820:Robatumumab
3810:Figitumumab
3805:Dalotuzumab
3800:Cixutumumab
3792:Antibodies:
3684:Rilotumumab
3679:Onartuzumab
3674:Flanvotumab
3661:Antibodies:
3629:PF-04217903
3559:Altiratinib
3522:HGF (c-Met)
3425:Antibodies:
3330:Antibodies:
3052:Duligotumab
3049:Antibodies:
2963:Trastuzumab
2953:Ertumaxomab
2950:Antibodies:
2921:Zalutumumab
2916:Panitumumab
2911:Nimotuzumab
2906:Necitumumab
2896:Imgatuzumab
2873:Antibodies:
2856:Osimertinib
2821:Dacomitinib
2716:Dapiclermin
2675:Antibodies:
2658:Altiratinib
2552:Wnt protein
2537:Somatomedin
2255:PDB gallery
2092:J. Neurosci
2049:J. Neurosci
1897:(1): 9–19.
1731:: 177–244.
1696:Development
1287:retinotopic
383:63,188,312
370:62,911,179
122:Identifiers
5286:Vandetanib
5251:Rebastinib
5246:Pegaptanib
5236:Nintedanib
5226:Lenvatinib
5191:Agerafenib
5144:Ripretinib
5069:CH-7057288
4968:CH-7057288
4833:7,8,3'-THF
4828:7,8,2'-THF
4754:Ranevetmab
4744:Fulranumab
4698:Rebastinib
4643:CH-7057288
4558:Cenegermin
4443:Agerafenib
4403:Agerafenib
4384:Vandetanib
4353:Vandetanib
4322:Vandetanib
4291:Vandetanib
4236:Olaratumab
4211:Ripretinib
4191:Nintedanib
4176:Lenvatinib
4166:Crenolanib
4151:Agerafenib
4070:Ranevetmab
4060:Fulranumab
3977:Cenegermin
3951:LNGF (p75)
3873:Xentuzumab
3835:Xentuzumab
3780:NVP-AEW541
3775:NVP-ADW742
3770:Linsitinib
3765:BMS-754807
3750:Mecasermin
3649:Tivantinib
3639:PHA-665752
3634:PF-2341066
3604:Golvatinib
3594:Crizotinib
3589:Capmatinib
3579:BMS-777607
3574:Amuvatinib
3450:Ersofermin
3413:Sprifermin
3369:Ersofermin
3318:Sprifermin
3308:Repifermin
3303:Palifermin
3236:Ersofermin
3215:Velafermin
3200:Repifermin
3153:Ersofermin
3072:ErbB4/HER4
3057:Patritumab
3018:ErbB3/HER3
2998:Mubritinib
2958:Pertuzumab
2931:ErbB2/HER2
2861:Vandetanib
2816:Canertinib
2811:Brigatinib
2806:Agerafenib
2786:Nepidermin
2781:Murodermin
2771:Epiregulin
2726:EGF (ErbB)
2684:Nesvacumab
2678:Evinacumab
2668:Rebastinib
2609:modulators
2532:Semaphorin
2517:Interferon
2490:Endothelin
1636:: 309–45.
1347:, May 2017
1326:, May 2017
1302:References
1239:receptor.
428:(ortholog)
165:HomoloGene
5311:Icrucumab
5291:WHI-P 154
5281:Tivozanib
5276:Toceranib
5271:Sunitinib
5266:Sorafenib
5261:Semaxanib
5241:Pazopanib
5231:Motesanib
5221:Lapatinib
5211:Cediranib
5149:Telbermin
5136:Agonists:
5084:GZ-389988
5064:CE-245677
5031:Agonists:
4983:GZ-389988
4963:CE-245677
4863:Diosmetin
4800:Agonists:
4766:Aptamers:
4759:Tanezumab
4734:Fasinumab
4678:Milciclib
4658:GZ-389988
4638:CE-245677
4540:Agonists:
4493:Toceranib
4488:Sunitinib
4483:Sorafenib
4473:Pazopanib
4468:Nilotinib
4463:Masitinib
4453:Dasatinib
4425:Agonists:
4371:Agonists:
4340:Agonists:
4309:Agonists:
4281:Liatermin
4273:Agonists:
4256:RET (GFL)
4246:Tovetumab
4226:Toceranib
4221:Sorafenib
4216:Sunitinib
4201:Radotinib
4196:Pazopanib
4186:Motesanib
4181:Masitinib
4116:Agonists:
4082:Aptamers:
4075:Tanezumab
4050:Fasinumab
3959:Agonists:
3815:Ganitumab
3735:IGF-1 LR3
3654:Volitinib
3609:INCB28060
3599:Foretinib
3505:Agonists:
3489:Trafermin
3447:Agonists:
3428:Burosumab
3418:Trafermin
3366:Agonists:
3333:Aprutumab
3323:Trafermin
3285:10 (KGF2)
3233:Agonists:
3210:Trafermin
3190:10 (KGF2)
3150:Agonists:
3080:Agonists:
3026:Agonists:
3008:Tucatinib
3003:Neratinib
2993:Lapatinib
2901:Matuzumab
2891:Futuximab
2876:Cetuximab
2866:WHI-P 154
2851:Neratinib
2846:Lapatinib
2836:Grandinin
2831:Gefitinib
2826:Erlotinib
2703:Agonists:
2663:CE-245677
2625:Agonists:
2563:see also
2443:Adipokine
2135:Genes Dev
1835:205014301
1291:posterior
1131:NP_997537
1127:NP_034239
1106:NP_001953
1080:NM_207654
1076:NM_010109
1055:NM_001962
885:Orthologs
173:GeneCards
5523:Category
5493:instead)
5482:Renalase
5443:instead)
5414:instead)
5361:instead)
5201:Axitinib
5170:D (FIGF)
5114:PLX-7486
5104:ONO-4474
5059:AZD-6918
5013:PLX-7486
5003:ONO-4474
4958:AZD-6918
4940:Ligands:
4858:Deprenyl
4818:7,3'-DHF
4749:MEDI-578
4729:ASP-6294
4693:PLX-7486
4683:ONO-4474
4633:AZD-6918
4593:ALE-0540
4514:instead.
4458:Imatinib
4448:Axitinib
4428:Ancestim
4393:Unsorted
4171:Imatinib
4161:Axitinib
4065:MEDI-578
4045:ASP-6294
4012:ALE-0540
3854:Agonists
3795:AVE-1642
3721:Agonists
3644:SU-11274
3530:Agonists
3508:FGF15/19
3498:Unsorted
3463:2 (bFGF)
3382:2 (bFGF)
3249:2 (bFGF)
3166:2 (bFGF)
2988:Afatinib
2939:Agonists
2841:Icotinib
2801:Afatinib
2747:Agonists
2485:Cytokine
2165:10601038
2122:10531456
2079:10366629
2036:20470923
1999:26773768
1878:18373575
1827:11256076
1798:11128993
1755:10730216
1716:10207129
1561:16818608
1553:15820684
1509:15643420
1501:15107857
1431:Cytokine
1396:Genomics
1343:–
1322:–
1296:anterior
1179:Wikidata
864:Sources:
679:membrane
5370:Ephrins
5074:DS-6051
4973:DS-6051
4878:LM22A-4
4868:DMAQ-B1
4823:7,8-DHF
4803:3,7-DHF
4772:RBM-004
4717:GBR-900
4648:DS-6051
4618:VM-902A
4088:RBM-004
3785:OSl-906
3745:Insulin
3624:MK-2461
3569:AMG-458
2706:Axokine
2333:ligands
2216:PDBe-KB
2206:UniProt
2195:PDBe-KB
2185:UniProt
2113:6782889
2070:6782661
2028:9751130
1991:9267020
1956:9195962
1921:1075856
1913:8755474
1870:7748564
1789:1692797
1687:9576626
1658:1278600
1650:9530499
1610:2537692
1602:7634326
1451:9245480
1416:8661153
1345:Ensembl
1324:Ensembl
1211:protein
997:UniProt
952:Ensembl
891:Species
870:QuickGO
694:caveola
516:utricle
403:pattern
129:Aliases
5340:Others
5034:BNN-20
4923:ANA-12
4848:BNN-20
4568:DHEA-S
4553:BNN-27
4548:BNN-20
3987:DHEA-S
3972:BNN-27
3967:BNN-20
3883:Others
3088:Epigen
2766:Epigen
2384:Ephrin
2211:O08543
2190:P52803
2163:
2156:317175
2153:
2120:
2110:
2077:
2067:
2034:
2026:
1997:
1989:
1954:
1919:
1911:
1891:Neuron
1876:
1868:
1848:Neuron
1833:
1825:
1796:
1786:
1753:
1743:
1714:
1685:
1656:
1648:
1608:
1600:
1559:
1551:
1507:
1499:
1449:
1414:
1165:search
1163:PubMed
1030:O08543
1011:P52803
907:Entrez
574:BioGPS
478:nipple
261:5q21.3
161:107444
153:601535
5489:(see
5439:(see
5410:(see
5357:(see
5089:K252a
4988:K252a
4663:K252a
4603:FX007
4363:GFRα4
4332:GFRα3
4301:GFRα2
4265:GFRα1
3893:IGFBP
3846:IGF-2
3825:R1507
3713:IGF-1
3619:K252a
3439:FGFR4
3358:FGFR3
3225:FGFR2
3142:FGFR1
2522:Kinin
2436:Other
2427:EFNB3
2422:EFNB2
2417:EFNB1
2412:EFNA5
2407:EFNA4
2402:EFNA3
2397:EFNA2
2392:EFNA1
2032:S2CID
1995:S2CID
1917:S2CID
1874:S2CID
1831:S2CID
1654:S2CID
1606:S2CID
1557:S2CID
1505:S2CID
1237:EphB2
1215:EFNA5
1209:is a
940:13640
900:Mouse
895:Human
866:Amigo
426:Mouse
419:Human
366:Start
301:Mouse
265:Start
198:Human
177:EFNA5
136:EFNA5
33:EFNA5
18:EFNA5
5491:here
5441:here
5412:here
5359:here
5154:VEGF
5128:VEGF
5044:NT-3
5039:DHEA
5023:TrkC
4943:DHEA
4913:TDP6
4893:NT-4
4888:NT-3
4873:HIOC
4843:BDNF
4792:TrkB
4563:DHEA
4532:TrkA
4512:here
4510:See
4503:TGFβ
4108:PDGF
4002:NT-4
3997:NT-3
3982:DHEA
3962:BDNF
2711:CNTF
2695:CNTF
2505:EDN3
2500:EDN2
2495:EDN1
2288:1shx
2273:1shw
2204:for
2183:for
2161:PMID
2118:PMID
2075:PMID
2024:PMID
1987:PMID
1969:Cell
1952:PMID
1909:PMID
1866:PMID
1823:PMID
1794:PMID
1751:PMID
1741:ISBN
1712:PMID
1683:PMID
1646:PMID
1598:PMID
1580:Cell
1549:PMID
1531:Cell
1497:PMID
1447:PMID
1412:PMID
1298:SC.
1218:gene
921:1946
540:hand
532:iris
409:Bgee
357:Band
318:Chr.
256:Band
215:Chr.
169:1482
149:OMIM
106:4M4R
102:4L0P
98:4BKA
94:4BK5
90:3MX0
86:2X11
67:RCSB
64:PDBe
4908:R13
4578:NGF
4523:Trk
3992:NGF
3704:IGF
3564:AM7
3455:FGF
3374:FGF
3275:),
3273:KGF
3241:FGF
3158:FGF
3133:FGF
2735:EGF
2202:PDB
2181:PDB
2151:PMC
2143:doi
2108:PMC
2100:doi
2065:PMC
2057:doi
2016:doi
1977:doi
1942:doi
1938:272
1899:doi
1856:doi
1815:doi
1784:PMC
1776:doi
1772:355
1733:doi
1729:196
1704:doi
1700:126
1675:doi
1638:doi
1588:doi
1539:doi
1535:121
1489:doi
1439:doi
1404:doi
379:End
278:End
181:OMA
157:MGI
57:PDB
5525::
5402:B3
5400:,
5398:B2
5396:,
5394:B1
5392:,
5390:A5
5388:,
5386:A4
5384:,
5382:A3
5380:,
5378:A2
5376:,
5374:A1
5168:,
5164:,
5160:,
4903:R7
4719:;
4138:,
4134:,
4130:,
3919:,
3915:,
3911:,
3907:,
3903:,
3899:,
3856::
3723::
3532::
3483:19
3481:,
3477:,
3473:,
3469:,
3465:,
3461:,
3402:23
3400:,
3398:18
3396:,
3392:,
3388:,
3384:,
3380:,
3297:22
3295:,
3293:18
3291:,
3289:17
3287:,
3283:,
3279:,
3267:,
3263:,
3259:,
3255:,
3251:,
3247:,
3194:20
3192:,
3188:,
3184:,
3180:,
3176:,
3172:,
3168:,
3164:,
3116:,
3112:,
3108:,
3104:,
3039:,
3035:,
2941::
2749::
2208::
2187::
2159:.
2149:.
2139:13
2137:.
2133:.
2116:.
2106:.
2096:19
2094:.
2090:.
2073:.
2063:.
2053:19
2051:.
2047:.
2030:.
2022:.
2012:10
2010:.
1993:.
1985:.
1973:90
1971:.
1967:.
1950:.
1936:.
1932:.
1915:.
1907:.
1895:17
1893:.
1889:.
1872:.
1864:.
1852:14
1850:.
1846:.
1829:.
1821:.
1809:.
1792:.
1782:.
1770:.
1766:.
1749:.
1739:.
1710:.
1698:.
1681:.
1671:77
1669:.
1652:.
1644:.
1634:21
1632:.
1604:.
1596:.
1584:82
1582:.
1578:.
1555:.
1547:.
1533:.
1529:.
1517:^
1503:.
1495:.
1483:.
1445:.
1433:.
1410:.
1400:35
1398:.
1378:.
1360:.
1331:^
1310:^
1220:.
868:/
385:bp
372:bp
284:bp
271:bp
179:;
175::
171:;
167::
163:;
159::
155:;
151::
104:,
100:,
96:,
92:,
88:,
5435:/
5404:)
5372:(
5172:)
5166:C
5162:B
5158:A
5156:(
4705:)
4142:)
4140:D
4136:C
4132:B
4128:A
4126:(
3923:)
3921:7
3917:6
3913:5
3909:4
3905:3
3901:2
3897:1
3895:(
3485:)
3479:9
3475:8
3471:6
3467:4
3459:1
3457:(
3404:)
3394:9
3390:8
3386:4
3378:1
3376:(
3299:)
3281:9
3277:8
3271:(
3269:7
3265:6
3261:5
3257:4
3253:3
3245:1
3243:(
3196:)
3186:8
3182:6
3178:5
3174:4
3170:3
3162:1
3160:(
3120:)
3114:4
3110:3
3106:2
3102:1
3100:(
3043:)
3037:2
3033:1
3031:(
2598:e
2591:t
2584:v
2324:e
2317:t
2310:v
2248:e
2241:t
2234:v
2218:.
2197:.
2167:.
2145::
2124:.
2102::
2081:.
2059::
2038:.
2018::
2001:.
1979::
1958:.
1944::
1923:.
1901::
1880:.
1858::
1837:.
1817::
1811:2
1800:.
1778::
1757:.
1735::
1718:.
1706::
1689:.
1677::
1660:.
1640::
1612:.
1590::
1563:.
1541::
1511:.
1491::
1485:7
1467:.
1453:.
1441::
1435:9
1418:.
1406::
1382:.
1364:.
303:)
200:)
183::
20:)
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