527:
482:
656:(IF3) and EF-G. The protein RF3 releases the Class I release factor so that it may occupy the ribosomal A site. EF-G hydrolyzes GTP and undergoes a large conformational change to push RF3 down the ribosome, which occurs alongside tRNA dissociation and promotes the ribosomal subunit rotation. This motion actively splits the B2a/B2b bridge, which connects the 30S and the 50S subunits, so that the ribosome can split. IF3 then isolates the 30S subunit to prevent re-association of the large and small subunits.
29:
625:
544:
movement of the 3' ends of both tRNA molecules on the large subunit from the A and P sites to the P and E sites, respectively, while the anticodon loops remain unshifted. This rotated ribosomal intermediate, in which the first tRNA occupies a hybrid A/P position and the second tRNA occupies a hybrid P/E position is a substrate for EF-G-GTP.
645:(RF1 or RF2) binds to the stop codon, which induces hydrolysis of the tRNA-peptide bond in the P site, allowing the newly-formed protein to exit the ribosome. The nascent peptide continues to fold and leaves the 70S ribosome, the mRNA, the deacylated tRNA (P site), and the Class I release factor (A site).
620:
The hydrolysis of GTP allows for a large conformational change within EF-G, forcing the A/P tRNA to fully occupy the P site, the P/E tRNA to fully occupy the E site (and exit the ribosome complex), and the mRNA to shift three nucleotides down relative to the ribosome. The GDP-bound EF-G molecule then
522:
The GTPase
Associated Center (GAC) is a region on the large ribosomal subunit that consists of two smaller regions of 23S ribosomal RNA called the L11 stalk and the sarcin-ricin loop (SRL). As a highly conserved rRNA loop in evolution, the SRL is critical in helping GTPases bind to the ribosome, but
465:
The five domains may be also separated into two super-domains. Super-domain I consists of
Domains I and II, and super-domain II consists of Domains III - IV. Throughout translocation, super-domain I will remain relatively unchanged, as it is responsible for binding tightly to the ribosome. However,
543:
center (PTC) has catalyzed the formation of a peptide bond between amino acids, moving the polypeptide chain from the P site tRNA to the A site tRNA. The 50S and 30S ribosomal subunits are now allowed to rotate relative to each other by approximately 7°. The subunit rotation is coupled with the
795:), respectively. The two roles of EF-G in elongation and termination of protein translation are split amongst the mitochondrial elongation factors, with mtEFG1 responsible for translocation and mtEFG2 responsible for termination and ribosomal recycling with mitochondrial
679:
prevents EF-G from binding stably to the ribosome, while the antibiotics dityromycin and GE82832 inhibit the activity of EF-G by preventing the translocation of the A site tRNA. Dityromycin and GE82832 do not affect the binding of EF-G to the ribosome, however.
466:
super-domain II will undergo a large rotational motion from the pre-translocational (PRE) state to the post-translocational (POST) state. Super-domain I is similar to the corresponding sections of
615:
3682:
3672:
3667:
3662:
3647:
3637:
3627:
3622:
3617:
3597:
3572:
3562:
3537:
3532:
3527:
3522:
3517:
3502:
697:
by binding to EF-G after one translocation event on the ribosome, preventing EF-G from dissociating. However, some bacterial strains have developed resistance to fusidic acid due to
1301:
Nyborg, J.; Nissen, P.; Kjeldgaard, M.; Thirup, S.; Polekhina, G.; Clark, B. F. (March 1996). "Structure of the ternary complex of EF-Tu: macromolecular mimicry in translation".
2441:
2436:
2431:
2426:
1030:
Carlson, Markus A.; Haddad, Bassam G.; Weis, Amanda J.; Blackwood, Colby S.; Shelton, Catherine D.; Wuerth, Michelle E.; Walter, Justin D.; Spiegel, Paul Clint (2017-06-01).
719:
EF-G has a complex evolutionary history, with numerous paralogous versions of the factor present in bacteria, suggesting subfunctionalization of different EF-G variants.
363:
3250:
171:
530:
Animation of the 70S ribosome with the P site tRNA (orange), E site tRNA (green), mRNA (yellow), and elongation factor G (red) in the POST state. PDB ID: 4W29
1631:
Das, Debasis; Samanta, Dibyendu; Bhattacharya, Arpita; Basu, Arunima; Das, Anindita; Ghosh, Jaydip; Chakrabarti, Abhijit; Gupta, Chanchal Das (2017-01-18).
3973:
2901:
523:
is not essential for GTP hydrolysis. There is some evidence to support that a phosphate oxygen in the A2662 residue of the SRL may help hydrolyze GTP.
2725:
539:
EF-G catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. In this process, the
2168:"A Computational Study of Elongation Factor G (EFG) Duplicated Genes: Diverged Nature Underlying the Innovation on the Same Structural Template"
4807:
2312:
190:
1859:
Bulkley, David; Brandi, Letizia; Polikanov, Yury S.; Fabbretti, Attilio; O’Connor, Michael; Gualerzi, Claudio O.; Steitz, Thomas A. (2014).
1801:"Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4"
551:, EF-G binds to the rotated ribosome near the A site in its GTP-bound state, and hydrolyzes GTP, releasing GDP and inorganic phosphate:
3280:
1346:"Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G"
450:, labeled Domain I through Domain V. Domain I may be referred to as the G-domain or as Domain I(G), since it binds to and hydrolyzes
307:
1032:"Ribosomal protein L7/L12 is required for GTPase translation factors EF-G, RF3, and IF2 to bind in their GTP state to 70S ribosomes"
4666:
4231:
4221:
4175:
3883:
3873:
3868:
3858:
3848:
3828:
3813:
3808:
3803:
3788:
3783:
3778:
3763:
3290:
3027:
2911:
458:
chain. Domain IV is important for translocation, as it undergoes a significant conformational change and enters the A site on the
4250:
3966:
3753:
3733:
3728:
3718:
2408:
2398:
2237:
Carbone, Christine E.; Loveland, Anna B.; Gamper, Howard B.; Hou, Ya-Ming; Demo, Gabriel; Korostelev, Andrei A. (December 2021).
183:
4196:
3327:
3323:
1252:
Zhang, Dejiu; Yan, Kaige; Zhang, Yiwei; Liu, Guangqiao; Cao, Xintao; Song, Guangtao; Xie, Qiang; Gao, Ning; Qin, Yan (2015).
514:, Release Factor 3, and EF-G. Specifically, the C-terminal of L7/L12 will bind to EF-G and is necessary for GTP hydrolysis.
240:
383:
150:
4165:
3702:
3697:
3692:
3687:
3677:
3657:
3652:
3642:
3632:
3612:
3607:
3602:
3592:
3587:
3582:
3577:
3567:
3557:
3552:
3547:
3542:
3319:
628:
Crystal structure of the ribosome with two tRNAs (orange and green) and EF-G (in cyan) after translocation. PDB ID: 4W29.
503:
459:
557:
3959:
3512:
3507:
3497:
2380:
2290:
2305:
1978:"Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation inStaphylococcus aureus"
4756:
3270:
3265:
3260:
2375:
2370:
653:
507:
4751:
3085:
1913:"Effect of Fusidic Acid on the Kinetics of Molecular Motions During EF-G-Induced Translocation on the Ribosome"
808:
144:
126:
672:
that prevent EF-G from binding to the ribosome, carrying out translocation or dissociating from the ribosome.
648:
In a GTP-dependent manner, the subsequent recycling is catalyzed by a Class II release factor named RF3/prfC,
371:
4853:
4773:
407:
131:
4821:
4343:
4138:
4066:
4062:
4039:
3999:
2451:
2298:
2029:"Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics"
1739:
Hirokawa, Go; Nijman, Romana M.; Raj, V. Samuel; Kaji, Hideko; Igarashi, Kazuei; Kaji, Akira (2005-08-01).
1976:
Koripella, Ravi Kiran; Chen, Yang; Peisker, Kristin; Koh, Cha San; Selmer, Maria; Sanyal, Suparna (2012).
4743:
2418:
2362:
642:
1400:
Maklan, E. J. (2012). Genetic and
Biochemical Analysis of the GTPase Associated Center of the Ribosome.
312:
195:
3448:
3388:
3235:
3225:
3215:
3175:
3155:
3130:
3105:
3080:
2280:
1419:"Functional Role of the Sarcin–Ricin Loop of the 23S rRNA in the Elongation Cycle of Protein Synthesis"
367:
119:
621:
dissociates from the complex, leaving another free A-site where the elongation cycle can start again.
4802:
4241:
4012:
3986:
3916:
3463:
3458:
3453:
3443:
3438:
3433:
3428:
3423:
3418:
3413:
3408:
3403:
3398:
3393:
3383:
3378:
3373:
3368:
3363:
3358:
3313:
3255:
3245:
3240:
3230:
3220:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3170:
3165:
3160:
3150:
3145:
3140:
3135:
3125:
3120:
3115:
3110:
3100:
3095:
3090:
3075:
3060:
1344:
Mandava, C. S.; Peisker, K.; Ederth, J.; Kumar, R.; Ge, X.; Szaflarski, W.; Sanyal, S. (2011-11-18).
796:
649:
319:
253:
1799:
Walter, Justin D.; Hunter, Margaret; Cobb, Melanie; Traeger, Geoff; Spiegel, P. Clint (2012-01-01).
324:
4357:
4052:
4017:
3990:
3940:
3353:
3348:
3343:
3333:
3308:
3303:
3070:
3065:
3055:
3050:
3045:
3040:
3035:
2284:
41:
147:
4727:
4690:
4029:
3951:
3936:
1861:"The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation"
1700:"Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G"
777:
71:
4457:
4097:
3482:
2337:
526:
451:
4587:
4495:
2329:
2325:
1633:"A Possible Role of the Full-Length Nascent Protein in Post-Translational Ribosome Recycling"
972:"The ribosome destabilizes native and non-native structures in a nascent multidomain protein"
837:
689:
411:
3338:
3298:
2333:
2321:
2179:
1924:
1644:
1533:
1100:
540:
350:
1579:
da Cunha, CE; Belardinelli, R; Peske, F; Holtkamp, W; Wintermeyer, W; Rodnina, MV (2013).
107:
8:
4792:
2863:
2124:"Evolution of elongation factor G and the origins of mitochondrial and chloroplast forms"
1148:"Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation"
825:
714:
665:
454:(GTP). Domain I also helps EF-G bind to the ribosome, and contains the N-terminal of the
2183:
1928:
1648:
1537:
1104:
83:
4373:
2320:
2265:
2238:
2210:
2167:
2099:
2004:
1977:
1953:
1912:
1885:
1860:
1833:
1800:
1773:
1740:
1675:
1632:
1605:
1580:
1556:
1521:
1497:
1470:
1443:
1418:
1378:
1345:
1278:
1253:
1229:
1196:
1172:
1147:
1123:
1089:"Following movement of domain IV of elongation factor G during ribosomal translocation"
1088:
1064:
1031:
1004:
971:
895:
870:
46:
1741:"The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits"
1314:
939:
922:
4047:
3009:
2826:
2353:
2215:
2197:
2145:
2091:
2086:
2069:
2050:
2009:
1958:
1940:
1890:
1838:
1820:
1778:
1760:
1721:
1680:
1662:
1610:
1561:
1502:
1448:
1383:
1365:
1326:
1318:
1283:
1234:
1216:
1177:
1128:
1069:
1051:
1009:
991:
970:
Liu, Kaixian; Rehfus, Joseph E.; Mattson, Elliot; Kaiser, Christian M. (2017-07-01).
952:
944:
900:
499:
481:
358:
245:
138:
2103:
485:
Crystal structure of EF-G in the POST state with
Domains I - V labeled. PDB ID: 4V5F
287:
4437:
4383:
4365:
2260:
2250:
2205:
2187:
2135:
2081:
2040:
1999:
1989:
1948:
1932:
1880:
1872:
1828:
1812:
1768:
1752:
1711:
1670:
1652:
1600:
1592:
1551:
1541:
1492:
1482:
1438:
1430:
1417:
Shi, Xinying; Khade, Prashant K.; Sanbonmatsu, Karissa Y.; Joseph, Simpson (2012).
1373:
1357:
1310:
1273:
1265:
1224:
1208:
1167:
1159:
1118:
1108:
1059:
1043:
999:
983:
934:
890:
882:
769:
723:
624:
346:
300:
4784:
4673:
4487:
4187:
4007:
2192:
2045:
2028:
1876:
1716:
1699:
1657:
758:
475:
233:
4107:
2971:
2255:
1936:
1163:
698:
447:
166:
1434:
1146:
Lin, Jinzhong; Gagnon, Matthieu G.; Bulkley, David; Steitz, Thomas A. (2015).
787:
From spdEFG1 and spdEFG2 evolved the mitochondrial elongation factors mtEFG1 (
4847:
4651:
4261:
3921:
2201:
1944:
1824:
1764:
1666:
1522:"Rotation of the head of the 30S ribosomal subunit during mRNA translocation"
1369:
1322:
1220:
1195:
Li, Wen; Trabuco, Leonardo G.; Schulten, Klaus; Frank, Joachim (2011-05-01).
1055:
995:
948:
751:
423:
2239:"Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP"
2140:
2123:
1994:
1546:
1487:
1405:
1113:
4636:
4609:
4538:
4531:
4514:
4509:
4483:
2523:
2390:
2219:
2149:
2095:
2054:
2013:
1962:
1894:
1842:
1782:
1725:
1684:
1614:
1565:
1506:
1452:
1387:
1287:
1238:
1181:
1132:
1073:
1013:
904:
684:
676:
419:
28:
1361:
1330:
956:
249:
4732:
3926:
1816:
1269:
773:
669:
1756:
4717:
4406:
3931:
1596:
1212:
1047:
638:
95:
1087:
Salsi, Enea; Farah, Elie; Dann, Jillian; Ermolenko, Dmitri N. (2014).
886:
750:- 3′. However, two other major forms of EF-G exist in some species of
4423:
3982:
3018:
987:
871:"Ribosomal translocation: one step closer to the molecular mechanism"
727:
462:, pushing the mRNA and tRNA molecules from the A site to the P site.
1254:"New insights into the enzymatic role of EF-G in ribosome recycling"
784:
group of bacteria that have elongation factors spdEFG1 and spdEFG2.
470:. Super-domain II in the POST state mimics the tRNA molecule of the
2933:
2928:
2923:
1581:"Dual use of GTP hydrolysis by elongation factor G on the ribosome"
694:
427:
228:
3981:
4828:
4797:
4575:
4570:
4329:
4319:
4294:
4289:
4024:
2654:
1578:
731:
455:
114:
2070:"Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp"
517:
4705:
4347:
4324:
4314:
4284:
4279:
4274:
4269:
4226:
4216:
4211:
4206:
4201:
4170:
4158:
4153:
4148:
4143:
4131:
4126:
4121:
4070:
3888:
3878:
3863:
3853:
3843:
3838:
3833:
3823:
3818:
3798:
3793:
3773:
3768:
2945:
2918:
2906:
2779:
2735:
2730:
2713:
2708:
2696:
2691:
2686:
2619:
2570:
2565:
2560:
2555:
2550:
2535:
2530:
2518:
2494:
2489:
2067:
1858:
842:
548:
415:
378:
178:
90:
78:
66:
506:
of the bacterial ribosome that binds to certain GTPases, like
4761:
4700:
4683:
4678:
4526:
4504:
4470:
4465:
4450:
4428:
4416:
4411:
4401:
4396:
4391:
4116:
4092:
3758:
3748:
3743:
3738:
3723:
3468:
3275:
2997:
2992:
2950:
2940:
2896:
2848:
2843:
2786:
2774:
2747:
2742:
2720:
2703:
2681:
2659:
2649:
2644:
2639:
2634:
2629:
2624:
2614:
2609:
2604:
2599:
2545:
2540:
2477:
2403:
819:
813:
511:
471:
467:
1300:
738:
and aEF2, respectively. In bacteria (and some archaea), the
4722:
4710:
4695:
4661:
4656:
4641:
4624:
4619:
4614:
4602:
4597:
4592:
4582:
4558:
4553:
4548:
4543:
4445:
2982:
2957:
2878:
2873:
2868:
2858:
2808:
2798:
2769:
2759:
2671:
2589:
2577:
2508:
2482:
2472:
2462:
2068:
Macvanin M, Johanson U, Ehrenberg M, Hughes D (July 2000).
831:
792:
788:
735:
340:
294:
282:
102:
1697:
1630:
1029:
4816:
4812:
1911:
Belardinelli, Riccardo; Rodnina, Marina V. (2017-09-05).
1471:"Three tRNAs on the ribosome slow translation elongation"
1416:
1343:
603:
578:
2236:
705:
gene, which prevents fusidic acid from binding to EF-G.
2166:
Margus, Tõnu; Remm, Maido; Tenson, Tanel (2011-08-04).
2121:
1975:
1798:
1086:
923:"DNA sequences from the str operon of Escherichia coli"
446:
operon, EF-G is made up of 704 amino acids that form 5
1194:
1145:
969:
768:
roteobacteria (which has since been split and renamed
1738:
742:
gene that encodes EF-G is found within the conserved
560:
1910:
868:
726:of life with similar function on the ribosome. The
610:{\displaystyle {\ce {GTP + H2O -> GDP + P_{i}}}}
1404:. Merritt ID: ark:/13030/m5js9t4d. Retrieved from
632:
609:
1201:Proteins: Structure, Function, and Bioinformatics
1197:"Molecular dynamics of EF-G during translocation"
534:
418:, EF-G catalyzes the movement (translocation) of
4845:
2165:
1251:
916:
914:
1698:Zavialov AV, Hauryliuk VV, Ehrenberg M (2005).
1526:Proceedings of the National Academy of Sciences
1475:Proceedings of the National Academy of Sciences
1093:Proceedings of the National Academy of Sciences
2026:
3967:
2306:
911:
518:Interaction with the GTPase Associated Center
2061:
2020:
1468:
3974:
3960:
2313:
2299:
1469:Choi, Junhong; Puglisi, Joseph D. (2017).
920:
869:Shoji, S; Walker, SE; Fredrick, K (2009).
2283:at the U.S. National Library of Medicine
2264:
2254:
2209:
2191:
2139:
2085:
2044:
2003:
1993:
1952:
1884:
1832:
1772:
1715:
1674:
1656:
1604:
1555:
1545:
1519:
1496:
1486:
1442:
1406:https://escholarship.org/uc/item/7gh9v43h
1377:
1277:
1228:
1171:
1122:
1112:
1063:
1003:
938:
894:
659:
623:
525:
480:
864:
862:
860:
858:
715:GTPase § Translation factor family
489:
4846:
921:Post, L. E.; Nomura, M. (1980-05-25).
722:Elongation factors exist in all three
3955:
2294:
2161:
2159:
2117:
2115:
2113:
1906:
1904:
1854:
1852:
1794:
1792:
1626:
1624:
1464:
1462:
637:Protein elongation continues until a
210:Translation elongation factor EFG/EF2
1025:
1023:
855:
494:
927:The Journal of Biological Chemistry
822:(elongation factor thermo unstable)
502:is only a multicopy protein on the
13:
2230:
2156:
2122:G C Atkinson; S L Baldauf (2011).
2110:
2027:Macvanin M, Hughes D (June 2005).
1901:
1849:
1789:
1621:
1459:
14:
4865:
2274:
1020:
816:(elongation factor thermo stable)
2087:10.1046/j.1365-2958.2000.01967.x
834:(eukaryotic elongation factor 2)
27:
2128:Molecular Biology and Evolution
1982:Journal of Biological Chemistry
1969:
1732:
1691:
1572:
1520:Guo, Z.; Noller, H. F. (2012).
1513:
1410:
1394:
1337:
641:appears on the mRNA. A Class I
633:Function in protein termination
1303:Trends in Biochemical Sciences
1294:
1245:
1188:
1139:
1080:
963:
809:Prokaryotic elongation factors
584:
535:Function in protein elongation
1:
1315:10.1016/S0968-0004(96)30008-X
940:10.1016/S0021-9258(19)85545-X
848:
408:prokaryotic elongation factor
335:Available protein structures:
16:Prokaryotic elongation factor
2193:10.1371/journal.pone.0022789
2046:10.1016/j.femsle.2005.05.007
1877:10.1016/j.celrep.2013.12.024
1717:10.1016/j.molcel.2005.05.016
1658:10.1371/journal.pone.0170333
1423:Journal of Molecular Biology
746:gene with the sequence 5′ -
708:
675:For example, the antibiotic
433:
7:
4744:Protein-synthesizing GTPase
2281:Peptide+Elongation+Factor+G
802:
22:Protein-synthesizing GTPase
10:
4870:
2256:10.1038/s41467-021-27415-0
1937:10.1038/s41598-017-10916-8
1164:10.1016/j.cell.2014.11.049
712:
4803:Guanylate-binding protein
4782:
4741:
4481:
4355:
4342:
4307:
4259:
4240:
4186:
4106:
4085:
4078:
4061:
4038:
3998:
3987:acid anhydride hydrolases
3917:Aminoacyl tRNA synthetase
3909:
3711:
3490:
3481:
3289:
3026:
3017:
3008:
2970:
2887:
2834:
2825:
2795:
2756:
2668:
2586:
2505:
2459:
2450:
2417:
2389:
2361:
2352:
2345:
2033:FEMS Microbiology Letters
1435:10.1016/j.jmb.2012.03.016
748:rpsL - rpsG - fusA - tufA
650:Ribosome recycling factor
377:
357:
339:
334:
330:
318:
306:
293:
281:
273:
268:
263:
239:
227:
219:
214:
209:
189:
177:
165:
160:
156:
137:
125:
113:
101:
89:
77:
65:
60:
56:Elongation factor G, EF-G
52:
40:
35:
26:
21:
4358:Heterotrimeric G protein
4053:Phosphoadenylylsulfatase
3941:Kozak consensus sequence
2285:Medical Subject Headings
402:, historically known as
4030:Thiamine-triphosphatase
3937:Shine-Dalgarno sequence
1995:10.1074/jbc.m112.378521
1547:10.1073/pnas.1218999109
1488:10.1073/pnas.1719592115
1114:10.1073/pnas.1410873111
778:Thermodesulfobacteriota
504:large ribosomal subunit
2074:Molecular Microbiology
1805:Nucleic Acids Research
1350:Nucleic Acids Research
1258:Nucleic Acids Research
629:
611:
531:
486:
452:guanosine triphosphate
4785:Polymerization motors
4496:Rho family of GTPases
2243:Nature Communications
2141:10.1093/molbev/msq316
828:(elongation factor P)
734:homologs of EF-G are
690:Staphylococcus aureus
660:Clinical significance
627:
612:
529:
484:
460:30S ribosomal subunit
4854:Protein biosynthesis
2837:Mitochondrial
2322:Protein biosynthesis
687:is known to inhibit
668:can be inhibited by
558:
541:peptidyl transferase
512:Elongation factor-Tu
490:EF-G on the ribosome
223:Transl_elong_EFG/EF2
4793:dynamin superfamily
2184:2011PLoSO...622789M
1988:(36): 30257–30267.
1929:2017NatSR...710536B
1757:10.1261/rna.2520405
1649:2017PLoSO..1270333D
1538:2012PNAS..10920391G
1532:(50): 20391–20394.
1481:(52): 13691–13696.
1362:10.1093/nar/gkr1031
1105:2014PNAS..11115060S
1099:(42): 15060–15065.
838:Protein translation
666:pathogenic bacteria
654:Initiation Factor 3
605:
580:
508:Initiation Factor 2
426:(mRNA) through the
400:elongation factor G
3010:Ribosomal Proteins
1917:Scientific Reports
1817:10.1093/nar/gkr623
1597:10.4161/trla.24315
1270:10.1093/nar/gkv995
1213:10.1002/prot.22976
1048:10.1111/febs.14067
780:), which form the
630:
607:
593:
568:
532:
487:
264:EFG/EF2, domain IV
4841:
4840:
4837:
4836:
4338:
4337:
4303:
4302:
4048:Adenylylsulfatase
3949:
3948:
3905:
3904:
3901:
3900:
3897:
3896:
3477:
3476:
2966:
2965:
2890:Eukaryotic
2827:Elongation factor
2821:
2820:
2817:
2816:
2354:Initiation factor
1042:(11): 1631–1643.
933:(10): 4660–4666.
887:10.1021/cb8002946
600:
596:
589:
583:
571:
564:
495:Binding to L7/L12
393:
392:
389:
388:
384:structure summary
259:
258:
205:
204:
201:
200:
120:metabolic pathway
4861:
4353:
4352:
4083:
4082:
4076:
4075:
3976:
3969:
3962:
3953:
3952:
3488:
3487:
3024:
3023:
3015:
3014:
2889:
2836:
2832:
2831:
2802:
2763:
2675:
2593:
2512:
2466:
2457:
2456:
2359:
2358:
2350:
2349:
2315:
2308:
2301:
2292:
2291:
2270:
2268:
2258:
2224:
2223:
2213:
2195:
2163:
2154:
2153:
2143:
2119:
2108:
2107:
2089:
2065:
2059:
2058:
2048:
2024:
2018:
2017:
2007:
1997:
1973:
1967:
1966:
1956:
1908:
1899:
1898:
1888:
1856:
1847:
1846:
1836:
1796:
1787:
1786:
1776:
1751:(8): 1317–1328.
1736:
1730:
1729:
1719:
1695:
1689:
1688:
1678:
1660:
1628:
1619:
1618:
1608:
1576:
1570:
1569:
1559:
1549:
1517:
1511:
1510:
1500:
1490:
1466:
1457:
1456:
1446:
1429:(3–4): 125–138.
1414:
1408:
1398:
1392:
1391:
1381:
1356:(5): 2054–2064.
1341:
1335:
1334:
1298:
1292:
1291:
1281:
1264:(21): 10525–33.
1249:
1243:
1242:
1232:
1207:(5): 1478–1486.
1192:
1186:
1185:
1175:
1158:(1–2): 219–227.
1143:
1137:
1136:
1126:
1116:
1084:
1078:
1077:
1067:
1036:The FEBS Journal
1027:
1018:
1017:
1007:
988:10.1002/pro.3189
982:(7): 1439–1451.
967:
961:
960:
942:
918:
909:
908:
898:
866:
770:Bdellovibrionota
616:
614:
613:
608:
606:
604:
601:
598:
594:
587:
581:
579:
576:
569:
562:
474:• GTP • aa-tRNA
412:mRNA translation
332:
331:
261:
260:
207:
206:
158:
157:
31:
19:
18:
4869:
4868:
4864:
4863:
4862:
4860:
4859:
4858:
4844:
4843:
4842:
4833:
4778:
4737:
4488:Ras superfamily
4477:
4461:
4441:
4387:
4377:
4369:
4334:
4299:
4255:
4236:
4182:
4139:Plasma membrane
4102:
4057:
4034:
4008:Pyrophosphatase
3994:
3980:
3950:
3945:
3893:
3707:
3473:
3285:
3004:
2962:
2883:
2813:
2796:
2791:
2757:
2752:
2669:
2664:
2587:
2582:
2506:
2501:
2460:
2446:
2413:
2385:
2341:
2319:
2277:
2233:
2231:Further reading
2228:
2227:
2164:
2157:
2120:
2111:
2066:
2062:
2025:
2021:
1974:
1970:
1909:
1902:
1857:
1850:
1797:
1790:
1737:
1733:
1696:
1692:
1643:(1): e0170333.
1629:
1622:
1577:
1573:
1518:
1514:
1467:
1460:
1415:
1411:
1399:
1395:
1342:
1338:
1299:
1295:
1250:
1246:
1193:
1189:
1144:
1140:
1085:
1081:
1028:
1021:
976:Protein Science
968:
964:
919:
912:
867:
856:
851:
805:
717:
711:
699:point mutations
683:The antibiotic
662:
635:
602:
597:
577:
572:
561:
559:
556:
555:
537:
520:
497:
492:
476:ternary complex
438:Encoded by the
436:
17:
12:
11:
5:
4867:
4857:
4856:
4839:
4838:
4835:
4834:
4832:
4831:
4826:
4825:
4824:
4819:
4810:
4805:
4800:
4789:
4787:
4780:
4779:
4777:
4776:
4771:
4770:
4769:
4764:
4759:
4748:
4746:
4739:
4738:
4736:
4735:
4730:
4725:
4720:
4715:
4714:
4713:
4708:
4703:
4698:
4688:
4687:
4686:
4681:
4671:
4670:
4669:
4664:
4659:
4647:
4646:
4645:
4644:
4639:
4629:
4628:
4627:
4622:
4617:
4607:
4606:
4605:
4600:
4595:
4585:
4580:
4579:
4578:
4573:
4563:
4562:
4561:
4556:
4551:
4546:
4536:
4535:
4534:
4529:
4519:
4518:
4517:
4512:
4507:
4492:
4490:
4479:
4478:
4476:
4475:
4474:
4473:
4468:
4459:
4455:
4454:
4453:
4448:
4439:
4435:
4434:
4433:
4432:
4431:
4421:
4420:
4419:
4414:
4404:
4399:
4394:
4385:
4381:
4380:
4379:
4375:
4367:
4362:
4360:
4350:
4340:
4339:
4336:
4335:
4333:
4332:
4327:
4322:
4317:
4311:
4309:
4305:
4304:
4301:
4300:
4298:
4297:
4292:
4287:
4282:
4277:
4272:
4266:
4264:
4257:
4256:
4254:
4253:
4247:
4245:
4238:
4237:
4235:
4234:
4229:
4224:
4219:
4214:
4209:
4204:
4199:
4193:
4191:
4184:
4183:
4181:
4180:
4179:
4178:
4173:
4163:
4162:
4161:
4156:
4151:
4146:
4136:
4135:
4134:
4129:
4124:
4113:
4111:
4104:
4103:
4101:
4100:
4095:
4089:
4087:
4086:Cu++ (3.6.3.4)
4080:
4073:
4059:
4058:
4056:
4055:
4050:
4044:
4042:
4036:
4035:
4033:
4032:
4027:
4022:
4021:
4020:
4015:
4004:
4002:
3996:
3995:
3979:
3978:
3971:
3964:
3956:
3947:
3946:
3944:
3943:
3934:
3929:
3924:
3919:
3913:
3911:
3910:Other concepts
3907:
3906:
3903:
3902:
3899:
3898:
3895:
3894:
3892:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3715:
3713:
3709:
3708:
3706:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3494:
3492:
3485:
3479:
3478:
3475:
3474:
3472:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3316:
3311:
3306:
3301:
3295:
3293:
3287:
3286:
3284:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3032:
3030:
3021:
3012:
3006:
3005:
3003:
3002:
3001:
3000:
2995:
2987:
2986:
2985:
2976:
2974:
2972:Release factor
2968:
2967:
2964:
2963:
2961:
2960:
2955:
2954:
2953:
2948:
2943:
2938:
2937:
2936:
2931:
2926:
2916:
2915:
2914:
2909:
2893:
2891:
2885:
2884:
2882:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2840:
2838:
2829:
2823:
2822:
2819:
2818:
2815:
2814:
2812:
2811:
2805:
2803:
2793:
2792:
2790:
2789:
2784:
2783:
2782:
2772:
2766:
2764:
2754:
2753:
2751:
2750:
2745:
2740:
2739:
2738:
2733:
2728:
2718:
2717:
2716:
2711:
2701:
2700:
2699:
2694:
2689:
2678:
2676:
2666:
2665:
2663:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2596:
2594:
2584:
2583:
2581:
2580:
2575:
2574:
2573:
2568:
2563:
2558:
2553:
2543:
2538:
2533:
2528:
2527:
2526:
2515:
2513:
2503:
2502:
2500:
2499:
2498:
2497:
2487:
2486:
2485:
2480:
2469:
2467:
2454:
2448:
2447:
2445:
2444:
2439:
2434:
2429:
2423:
2421:
2415:
2414:
2412:
2411:
2406:
2401:
2395:
2393:
2387:
2386:
2384:
2383:
2378:
2373:
2367:
2365:
2356:
2347:
2343:
2342:
2318:
2317:
2310:
2303:
2295:
2289:
2288:
2276:
2275:External links
2273:
2272:
2271:
2232:
2229:
2226:
2225:
2155:
2134:(3): 1281–92.
2109:
2060:
2019:
1968:
1900:
1871:(2): 357–365.
1848:
1811:(1): 360–370.
1788:
1731:
1710:(6): 675–686.
1704:Molecular Cell
1690:
1620:
1571:
1512:
1458:
1409:
1393:
1336:
1293:
1244:
1187:
1138:
1079:
1019:
962:
910:
853:
852:
850:
847:
846:
845:
840:
835:
829:
823:
817:
811:
804:
801:
791:) and mtEFG2 (
762:lanctomycetota
710:
707:
661:
658:
643:release factor
634:
631:
618:
617:
592:
586:
575:
567:
536:
533:
519:
516:
496:
493:
491:
488:
435:
432:
391:
390:
387:
386:
381:
375:
374:
361:
355:
354:
344:
337:
336:
328:
327:
322:
316:
315:
310:
304:
303:
298:
291:
290:
285:
279:
278:
275:
271:
270:
266:
265:
257:
256:
243:
237:
236:
231:
225:
224:
221:
217:
216:
212:
211:
203:
202:
199:
198:
193:
187:
186:
181:
175:
174:
169:
163:
162:
154:
153:
142:
135:
134:
129:
123:
122:
117:
111:
110:
105:
99:
98:
93:
87:
86:
81:
75:
74:
69:
63:
62:
58:
57:
54:
50:
49:
44:
38:
37:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
4866:
4855:
4852:
4851:
4849:
4830:
4827:
4823:
4820:
4818:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4795:
4794:
4791:
4790:
4788:
4786:
4781:
4775:
4772:
4768:
4765:
4763:
4760:
4758:
4755:
4754:
4753:
4750:
4749:
4747:
4745:
4740:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4693:
4692:
4689:
4685:
4682:
4680:
4677:
4676:
4675:
4672:
4668:
4665:
4663:
4660:
4658:
4655:
4654:
4653:
4649:
4648:
4643:
4640:
4638:
4635:
4634:
4633:
4630:
4626:
4623:
4621:
4618:
4616:
4613:
4612:
4611:
4608:
4604:
4601:
4599:
4596:
4594:
4591:
4590:
4589:
4586:
4584:
4581:
4577:
4574:
4572:
4569:
4568:
4567:
4564:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4541:
4540:
4537:
4533:
4530:
4528:
4525:
4524:
4523:
4520:
4516:
4513:
4511:
4508:
4506:
4503:
4502:
4501:
4497:
4494:
4493:
4491:
4489:
4485:
4480:
4472:
4469:
4467:
4464:
4463:
4462:
4456:
4452:
4449:
4447:
4444:
4443:
4442:
4436:
4430:
4427:
4426:
4425:
4422:
4418:
4415:
4413:
4410:
4409:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4389:
4388:
4382:
4378:
4372:
4371:
4370:
4364:
4363:
4361:
4359:
4354:
4351:
4349:
4345:
4341:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4312:
4310:
4306:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4267:
4265:
4263:
4262:P-type ATPase
4258:
4252:
4249:
4248:
4246:
4243:
4239:
4233:
4230:
4228:
4225:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4194:
4192:
4189:
4185:
4177:
4174:
4172:
4169:
4168:
4167:
4164:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4141:
4140:
4137:
4133:
4130:
4128:
4125:
4123:
4120:
4119:
4118:
4115:
4114:
4112:
4109:
4105:
4099:
4096:
4094:
4091:
4090:
4088:
4084:
4081:
4077:
4074:
4072:
4068:
4064:
4060:
4054:
4051:
4049:
4046:
4045:
4043:
4041:
4037:
4031:
4028:
4026:
4023:
4019:
4016:
4014:
4011:
4010:
4009:
4006:
4005:
4003:
4001:
3997:
3992:
3988:
3984:
3977:
3972:
3970:
3965:
3963:
3958:
3957:
3954:
3942:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3922:Reading frame
3920:
3918:
3915:
3914:
3912:
3908:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3716:
3714:
3710:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3495:
3493:
3489:
3486:
3484:
3483:Mitochondrial
3480:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3329:
3325:
3321:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3296:
3294:
3292:
3288:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3033:
3031:
3029:
3025:
3022:
3020:
3016:
3013:
3011:
3007:
2999:
2996:
2994:
2991:
2990:
2988:
2984:
2981:
2980:
2978:
2977:
2975:
2973:
2969:
2959:
2956:
2952:
2949:
2947:
2944:
2942:
2939:
2935:
2932:
2930:
2927:
2925:
2922:
2921:
2920:
2917:
2913:
2910:
2908:
2905:
2904:
2903:
2900:
2899:
2898:
2895:
2894:
2892:
2886:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2841:
2839:
2833:
2830:
2828:
2824:
2810:
2807:
2806:
2804:
2801:
2800:
2794:
2788:
2785:
2781:
2778:
2777:
2776:
2773:
2771:
2768:
2767:
2765:
2762:
2761:
2755:
2749:
2746:
2744:
2741:
2737:
2734:
2732:
2729:
2727:
2724:
2723:
2722:
2719:
2715:
2712:
2710:
2707:
2706:
2705:
2702:
2698:
2695:
2693:
2690:
2688:
2685:
2684:
2683:
2680:
2679:
2677:
2674:
2673:
2667:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2597:
2595:
2592:
2591:
2585:
2579:
2576:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2525:
2522:
2521:
2520:
2517:
2516:
2514:
2511:
2510:
2504:
2496:
2493:
2492:
2491:
2488:
2484:
2481:
2479:
2476:
2475:
2474:
2471:
2470:
2468:
2465:
2464:
2458:
2455:
2453:
2449:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2424:
2422:
2420:
2416:
2410:
2407:
2405:
2402:
2400:
2397:
2396:
2394:
2392:
2391:Mitochondrial
2388:
2382:
2379:
2377:
2374:
2372:
2369:
2368:
2366:
2364:
2360:
2357:
2355:
2351:
2348:
2344:
2339:
2335:
2331:
2327:
2323:
2316:
2311:
2309:
2304:
2302:
2297:
2296:
2293:
2286:
2282:
2279:
2278:
2267:
2262:
2257:
2252:
2248:
2244:
2240:
2235:
2234:
2221:
2217:
2212:
2207:
2203:
2199:
2194:
2189:
2185:
2181:
2178:(8): e22789.
2177:
2173:
2169:
2162:
2160:
2151:
2147:
2142:
2137:
2133:
2129:
2125:
2118:
2116:
2114:
2105:
2101:
2097:
2093:
2088:
2083:
2080:(1): 98–107.
2079:
2075:
2071:
2064:
2056:
2052:
2047:
2042:
2039:(2): 215–20.
2038:
2034:
2030:
2023:
2015:
2011:
2006:
2001:
1996:
1991:
1987:
1983:
1979:
1972:
1964:
1960:
1955:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1907:
1905:
1896:
1892:
1887:
1882:
1878:
1874:
1870:
1866:
1862:
1855:
1853:
1844:
1840:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1795:
1793:
1784:
1780:
1775:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1735:
1727:
1723:
1718:
1713:
1709:
1705:
1701:
1694:
1686:
1682:
1677:
1672:
1668:
1664:
1659:
1654:
1650:
1646:
1642:
1638:
1634:
1627:
1625:
1616:
1612:
1607:
1602:
1598:
1594:
1591:(1): e24315.
1590:
1586:
1582:
1575:
1567:
1563:
1558:
1553:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1516:
1508:
1504:
1499:
1494:
1489:
1484:
1480:
1476:
1472:
1465:
1463:
1454:
1450:
1445:
1440:
1436:
1432:
1428:
1424:
1420:
1413:
1407:
1403:
1402:UC Santa Cruz
1397:
1389:
1385:
1380:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1340:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1297:
1289:
1285:
1280:
1275:
1271:
1267:
1263:
1259:
1255:
1248:
1240:
1236:
1231:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1191:
1183:
1179:
1174:
1169:
1165:
1161:
1157:
1153:
1149:
1142:
1134:
1130:
1125:
1120:
1115:
1110:
1106:
1102:
1098:
1094:
1090:
1083:
1075:
1071:
1066:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1026:
1024:
1015:
1011:
1006:
1001:
997:
993:
989:
985:
981:
977:
973:
966:
958:
954:
950:
946:
941:
936:
932:
928:
924:
917:
915:
906:
902:
897:
892:
888:
884:
881:(2): 93–107.
880:
876:
875:ACS Chem Biol
872:
865:
863:
861:
859:
854:
844:
841:
839:
836:
833:
830:
827:
824:
821:
818:
815:
812:
810:
807:
806:
800:
798:
794:
790:
785:
783:
779:
775:
771:
767:
763:
761:
756:
754:
749:
745:
741:
737:
733:
729:
725:
720:
716:
706:
704:
700:
696:
692:
691:
686:
681:
678:
673:
671:
667:
657:
655:
651:
646:
644:
640:
626:
622:
590:
573:
565:
554:
553:
552:
550:
545:
542:
528:
524:
515:
513:
509:
505:
501:
483:
479:
477:
473:
469:
463:
461:
457:
453:
449:
445:
441:
431:
429:
425:
424:messenger RNA
421:
417:
413:
409:
405:
401:
397:
385:
382:
380:
376:
373:
369:
365:
362:
360:
356:
352:
348:
345:
342:
338:
333:
329:
326:
323:
321:
317:
314:
311:
309:
305:
302:
299:
296:
292:
289:
286:
284:
280:
276:
272:
267:
262:
255:
251:
247:
244:
242:
238:
235:
232:
230:
226:
222:
218:
213:
208:
197:
194:
192:
188:
185:
182:
180:
176:
173:
170:
168:
164:
159:
155:
152:
149:
146:
143:
140:
136:
133:
130:
128:
124:
121:
118:
116:
112:
109:
106:
104:
100:
97:
96:NiceZyme view
94:
92:
88:
85:
82:
80:
76:
73:
70:
68:
64:
59:
55:
51:
48:
45:
43:
39:
34:
30:
25:
20:
4766:
4631:
4565:
4521:
4499:
4484:Small GTPase
4098:Wilson/ATP7B
4093:Menkes/ATP7A
2989:Class 2/RF3
2853:
2797:
2758:
2670:
2588:
2507:
2461:
2246:
2242:
2175:
2171:
2131:
2127:
2077:
2073:
2063:
2036:
2032:
2022:
1985:
1981:
1971:
1923:(1): 10536.
1920:
1916:
1868:
1865:Cell Reports
1864:
1808:
1804:
1748:
1744:
1734:
1707:
1703:
1693:
1640:
1636:
1588:
1584:
1574:
1529:
1525:
1515:
1478:
1474:
1426:
1422:
1412:
1401:
1396:
1353:
1349:
1339:
1309:(3): 81–82.
1306:
1302:
1296:
1261:
1257:
1247:
1204:
1200:
1190:
1155:
1151:
1141:
1096:
1092:
1082:
1039:
1035:
979:
975:
965:
930:
926:
878:
874:
786:
781:
765:
759:
755:pirochaetota
752:
747:
743:
739:
721:
718:
702:
688:
685:fusidic acid
682:
677:thiostrepton
674:
663:
647:
636:
619:
546:
538:
521:
498:
464:
443:
442:gene on the
439:
437:
420:transfer RNA
410:involved in
403:
399:
395:
394:
84:BRENDA entry
4808:Mitofusin-1
4783:3.6.5.5-6:
4752:Prokaryotic
3927:Start codon
3712:28S subunit
3491:39S subunit
3291:40S subunit
3028:60S subunit
3019:Cytoplasmic
2483:SUI1 family
2326:translation
2249:(1): 7236.
1585:Translation
774:Myxococcota
670:antibiotics
456:polypeptide
422:(tRNA) and
404:translocase
269:Identifiers
215:Identifiers
72:IntEnz view
36:Identifiers
4774:Eukaryotic
4407:Transducin
4244:(3.6.3.10)
3983:Hydrolases
3932:Stop codon
3276:RRP15-like
3086:RPL10-like
2835:Bacterial/
2452:Eukaryotic
2338:eukaryotic
849:References
728:eukaryotic
713:See also:
693:and other
639:stop codon
347:structures
141:structures
108:KEGG entry
53:Alt. names
4742:3.6.5.3:
4482:3.6.5.2:
4424:Gustducin
4356:3.6.5.1:
4190:(3.6.3.9)
4110:(3.6.3.8)
4013:Inorganic
2888:Archaeal/
2363:Bacterial
2330:bacterial
2202:1932-6203
1945:2045-2322
1825:0305-1048
1765:1355-8382
1667:1932-6203
1370:0305-1048
1323:0968-0004
1221:1097-0134
1056:1742-4658
996:1469-896X
949:0021-9258
709:Evolution
585:⟶
434:Structure
234:IPR004540
61:Databases
4848:Category
4018:Thiamine
2979:Class 1
2419:Archaeal
2346:Proteins
2334:archaeal
2220:21829651
2172:PLOS ONE
2150:21097998
2104:10307058
2096:10931308
2055:15935566
2014:22767604
1963:28874811
1895:24412368
1843:21908407
1783:16043510
1726:15949442
1685:28099529
1637:PLOS ONE
1615:26824016
1566:23188795
1507:29229848
1453:22459262
1388:22102582
1288:26432831
1239:21365677
1182:25594181
1133:25288752
1074:28342293
1014:28474852
905:19173642
803:See also
764:, and δ-
695:bacteria
664:EF-G in
428:ribosome
364:RCSB PDB
229:InterPro
196:proteins
184:articles
172:articles
145:RCSB PDB
4829:Tubulin
4798:Dynamin
4650:other:
4330:Katanin
4320:Kinesin
4295:ATP13A3
4290:ATP13A2
4025:Apyrase
3281:RSL24D1
2958:a/eEF-2
2897:a/eEF-1
2266:8668904
2211:3150367
2180:Bibcode
2005:3436278
1954:5585275
1925:Bibcode
1886:5331365
1834:3245911
1774:1370814
1676:5242463
1645:Bibcode
1606:4718068
1557:3528506
1534:Bibcode
1498:5748233
1444:3348345
1379:3299993
1331:8882578
1279:4666400
1230:3132869
1173:4297320
1124:4210333
1101:Bibcode
1065:5568246
1005:5477528
957:6989816
896:3010847
732:archeal
724:domains
701:in the
652:(RRF),
448:domains
414:. As a
406:) is a
325:cd01434
313:SM00889
288:PF03764
132:profile
115:MetaCyc
47:3.6.5.3
4706:ARL13B
4566:RhoBTB
4460:α12/13
4348:GTPase
4325:Myosin
4315:Dynein
4285:ATP12A
4280:ATP11B
4275:ATP10A
4270:ATP8B1
4260:Other
4232:ATP1B4
4227:ATP1B3
4222:ATP1B2
4217:ATP1B1
4212:ATP1A4
4207:ATP1A3
4202:ATP1A2
4197:ATP1A1
4188:Na+/K+
4176:ATP2C2
4171:ATP2C1
4159:ATP2B4
4154:ATP2B3
4149:ATP2B2
4144:ATP2B1
4132:ATP2A3
4127:ATP2A2
4122:ATP2A1
4071:ATPase
3449:RPS27A
3389:RPS15A
3328:RPS4Y2
3324:RPS4Y1
3318:RPS4 (
3236:RPL37A
3226:RPL36A
3216:RPL35A
3176:RPL27A
3156:RPL23A
3131:RPL18A
3106:RPL13A
3081:RPL10A
2536:γ
2531:β
2524:kinase
2519:α
2287:(MeSH)
2263:
2218:
2208:
2200:
2148:
2102:
2094:
2053:
2012:
2002:
1961:
1951:
1943:
1893:
1883:
1841:
1831:
1823:
1781:
1771:
1763:
1724:
1683:
1673:
1665:
1613:
1603:
1564:
1554:
1505:
1495:
1451:
1441:
1386:
1376:
1368:
1329:
1321:
1286:
1276:
1237:
1227:
1219:
1180:
1170:
1131:
1121:
1072:
1062:
1054:
1012:
1002:
994:
955:
947:
903:
893:
843:GTPase
776:, and
549:GTPase
500:L7/L12
416:GTPase
379:PDBsum
353:
343:
301:CL0329
277:EFG_IV
274:Symbol
254:SUPFAM
220:Symbol
179:PubMed
161:Search
151:PDBsum
91:ExPASy
79:BRENDA
67:IntEnz
42:EC no.
4762:EF-Tu
4701:SAR1B
4684:RAB27
4679:RAB23
4632:RhoDF
4522:RhoUV
4505:CDC42
4500:Cdc42
4486:>
4471:GNA13
4466:GNA12
4451:GNA11
4440:αq/11
4429:GNAT3
4417:GNAT2
4412:GNAT1
4402:GNAI3
4397:GNAI2
4392:GNAI1
4344:3.6.5
4308:3.6.4
4251:ATP4A
4242:H+/K+
4117:SERCA
4079:3.6.3
4063:3.6.3
4040:3.6.2
4000:3.6.1
3719:MRPS1
3498:MRPL1
3469:RACK1
3464:RPS30
3459:RPS29
3454:RPS28
3444:RPS27
3439:RPS26
3434:RPS25
3429:RPS24
3424:RPS23
3419:RPS21
3414:RPS20
3409:RPS19
3404:RPS18
3399:RPS17
3394:RPS16
3384:RPS15
3379:RPS14
3374:RPS13
3369:RPS12
3364:RPS11
3359:RPS10
3320:RPS4X
3314:RPS3A
3271:RPLP2
3266:RPLP1
3261:RPLP0
3256:RPL41
3251:RPL40
3246:RPL39
3241:RPL38
3231:RPL37
3221:RPL36
3211:RPL35
3206:RPL34
3201:RPL32
3196:RPL31
3191:RPL30
3186:RPL29
3181:RPL28
3171:RPL27
3166:RPL26
3161:RPL24
3151:RPL23
3146:RPL22
3141:RPL21
3136:RPL19
3126:RPL18
3121:RPL17
3116:RPL15
3111:RPL14
3101:RPL13
3096:RPL12
3091:RPL11
3076:RPL10
3061:RPL7A
2998:GSPT2
2993:GSPT1
2849:EF-Ts
2844:EF-Tu
2775:EIF5A
2578:eIF2D
2546:eIF2B
2541:eIF2A
2490:eIF1A
2409:MTIF3
2404:MTIF2
2399:MTIF1
2100:S2CID
820:EF-Tu
814:EF-Ts
547:As a
472:EF-Tu
468:EF-Tu
308:SMART
250:SCOPe
241:SCOP2
127:PRIAM
4822:OPA1
4815:and
4767:EF-G
4757:IF-2
4723:Rheb
4711:ARL6
4696:ARF6
4667:NRAS
4662:KRAS
4657:HRAS
4642:RhoD
4637:RhoF
4583:RhoH
4559:RhoG
4544:Rac1
4532:RhoV
4527:RhoU
4510:TC10
4446:GNAQ
4166:SPCA
3993:3.6)
3354:RPS9
3349:RPS8
3344:RPS7
3339:RPS6
3334:RPS5
3309:RPS3
3304:RPS2
3299:RPSA
3071:RPL9
3066:RPL8
3056:RPL7
3051:RPL6
3046:RPL5
3041:RPL4
3036:RPL3
2983:eRF1
2879:GFM2
2874:GFM1
2869:TSFM
2864:EF-P
2859:EF-4
2854:EF-G
2809:EIF6
2799:eIF6
2770:EIF5
2760:eIF5
2672:eIF4
2590:eIF3
2509:eIF2
2473:eIF1
2463:eIF1
2442:aIF6
2437:aIF5
2432:aIF2
2427:aIF1
2216:PMID
2198:ISSN
2146:PMID
2092:PMID
2051:PMID
2010:PMID
1959:PMID
1941:ISSN
1891:PMID
1839:PMID
1821:ISSN
1779:PMID
1761:ISSN
1722:PMID
1681:PMID
1663:ISSN
1611:PMID
1562:PMID
1503:PMID
1449:PMID
1384:PMID
1366:ISSN
1327:PMID
1319:ISSN
1284:PMID
1235:PMID
1217:ISSN
1178:PMID
1152:Cell
1129:PMID
1070:PMID
1052:ISSN
1010:PMID
992:ISSN
953:PMID
945:ISSN
901:PMID
832:eEF2
826:EF-P
793:GFM2
789:GFM1
740:fusA
736:eEF2
730:and
703:fusA
440:fusA
396:EF-G
372:PDBj
368:PDBe
351:ECOD
341:Pfam
297:clan
295:Pfam
283:Pfam
246:1n0u
191:NCBI
148:PDBe
103:KEGG
4817:MX2
4813:MX1
4733:RGK
4728:Rap
4718:Ran
4691:Arf
4674:Rab
4652:Ras
4610:Rnd
4588:Rho
4539:Rac
4515:TCL
4376:olf
4108:Ca+
2381:IF3
2376:IF2
2371:IF1
2261:PMC
2251:doi
2206:PMC
2188:doi
2136:doi
2082:doi
2041:doi
2037:247
2000:PMC
1990:doi
1986:287
1949:PMC
1933:doi
1881:PMC
1873:doi
1829:PMC
1813:doi
1769:PMC
1753:doi
1745:RNA
1712:doi
1671:PMC
1653:doi
1601:PMC
1593:doi
1552:PMC
1542:doi
1530:109
1493:PMC
1483:doi
1479:114
1439:PMC
1431:doi
1427:419
1374:PMC
1358:doi
1311:doi
1274:PMC
1266:doi
1225:PMC
1209:doi
1168:PMC
1160:doi
1156:160
1119:PMC
1109:doi
1097:111
1060:PMC
1044:doi
1040:284
1000:PMC
984:doi
935:doi
931:255
891:PMC
883:doi
797:RRF
782:spd
744:str
588:GDP
563:GTP
444:str
359:PDB
320:CDD
167:PMC
139:PDB
4850::
4498::
4386:αi
4368:αs
4346::
4069::
3991:EC
3985::
3889:35
3884:34
3879:33
3874:32
3869:31
3864:30
3859:29
3854:28
3849:27
3844:26
3839:25
3834:24
3829:23
3824:22
3819:21
3814:20
3809:19
3804:18
3799:17
3794:16
3789:15
3784:14
3779:13
3774:12
3769:11
3764:10
3703:42
3698:41
3693:40
3688:39
3683:38
3678:37
3673:36
3668:35
3663:34
3658:33
3653:32
3648:31
3643:30
3638:29
3633:28
3628:27
3623:26
3618:25
3613:24
3608:23
3603:22
3598:21
3593:20
3588:19
3583:18
3578:17
3573:16
3568:15
3563:14
3558:13
3553:12
3548:11
3543:10
3326:,
3322:,
2934:P3
2929:P2
2924:P1
2902:A1
2787:5B
2704:E1
2336:,
2332:,
2324::
2259:.
2247:12
2245:.
2241:.
2214:.
2204:.
2196:.
2186:.
2174:.
2170:.
2158:^
2144:.
2132:28
2130:.
2126:.
2112:^
2098:.
2090:.
2078:37
2076:.
2072:.
2049:.
2035:.
2031:.
2008:.
1998:.
1984:.
1980:.
1957:.
1947:.
1939:.
1931:.
1919:.
1915:.
1903:^
1889:.
1879:.
1867:.
1863:.
1851:^
1837:.
1827:.
1819:.
1809:40
1807:.
1803:.
1791:^
1777:.
1767:.
1759:.
1749:11
1747:.
1743:.
1720:.
1708:18
1706:.
1702:.
1679:.
1669:.
1661:.
1651:.
1641:12
1639:.
1635:.
1623:^
1609:.
1599:.
1587:.
1583:.
1560:.
1550:.
1540:.
1528:.
1524:.
1501:.
1491:.
1477:.
1473:.
1461:^
1447:.
1437:.
1425:.
1421:.
1382:.
1372:.
1364:.
1354:40
1352:.
1348:.
1325:.
1317:.
1307:21
1305:.
1282:.
1272:.
1262:43
1260:.
1256:.
1233:.
1223:.
1215:.
1205:79
1203:.
1199:.
1176:.
1166:.
1154:.
1150:.
1127:.
1117:.
1107:.
1095:.
1091:.
1068:.
1058:.
1050:.
1038:.
1034:.
1022:^
1008:.
998:.
990:.
980:26
978:.
974:.
951:.
943:.
929:.
925:.
913:^
899:.
889:.
877:.
873:.
857:^
799:.
772:,
757:,
510:,
478:.
430:.
370:;
366:;
349:/
252:/
248:/
4625:3
4620:2
4615:1
4603:C
4598:B
4593:A
4576:2
4571:1
4554:3
4549:2
4458:G
4438:G
4384:G
4374:G
4366:G
4067:4
4065:-
3989:(
3975:e
3968:t
3961:v
3939:/
3759:9
3754:8
3749:7
3744:6
3739:5
3734:4
3729:3
3724:2
3538:9
3533:8
3528:7
3523:6
3518:5
3513:4
3508:3
3503:2
3330:)
2951:G
2946:E
2941:D
2919:B
2912:3
2907:2
2780:2
2748:H
2743:B
2736:3
2731:2
2726:1
2721:G
2714:3
2709:2
2697:3
2692:2
2687:1
2682:A
2660:M
2655:L
2650:K
2645:J
2640:I
2635:H
2630:G
2625:F
2620:E
2615:D
2610:C
2605:B
2600:A
2571:5
2566:4
2561:3
2556:2
2551:1
2495:Y
2478:B
2340:)
2328:(
2314:e
2307:t
2300:v
2269:.
2253::
2222:.
2190::
2182::
2176:6
2152:.
2138::
2106:.
2084::
2057:.
2043::
2016:.
1992::
1965:.
1935::
1927::
1921:7
1897:.
1875::
1869:6
1845:.
1815::
1785:.
1755::
1728:.
1714::
1687:.
1655::
1647::
1617:.
1595::
1589:1
1568:.
1544::
1536::
1509:.
1485::
1455:.
1433::
1390:.
1360::
1333:.
1313::
1290:.
1268::
1241:.
1211::
1184:.
1162::
1135:.
1111::
1103::
1076:.
1046::
1016:.
986::
959:.
937::
907:.
885::
879:4
766:P
760:P
753:S
599:i
595:P
591:+
582:O
574:2
570:H
566:+
398:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
