163:. They did not find indications of XMRV in the blood of the patients tested, and also concluded from their experiments that XMRV does not, "survive well in human blood", so human infection is unlikely. They also stated that research results published by others suggested that laboratory contamination may have resulted in false positive results in the original study.
109:
drug
Ampligen. The drug was administered in his Incline Village facility and three other sites. Peterson and others reported that there was statistically significant improvement in the patients receiving Ampligen. He is a principal investigator of the FDA-approved open-label safety and efficacy phase
96:
improvement in the first patient enabled the next pilot study of
Ampligen in ME/CFS patients by Peterson and other researchers. During the 1990 CFIDS Conference in Charlotte, North Carolina, Peterson described positive results in 15 CFS patents after he treated them with Ampligen for approximately 6
386:
Suhadolnik, R.J.; Reichenbach, N.L.; Hitzges, P.; Adelson, M.E.; Peterson, D.L.; Cheney, P.; Salvato, P.; Thompson, C.; Loveless, M.; Muller, W.E.; et al. (1994). "Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue
72:
region. From 1984 to 1987, the illness was recorded in 259 patients in the area by the two physicians. The Lake Tahoe outbreak became the subject of several studies by
Peterson and others. In 1995, Peterson and other investigators started conducting a 10-year follow-up study on patients seen during
269:
Shetzline, Susan E.; Martinand-Mari, Camille; Reichenbach, Nancy L.; Buletic, Zivjena; Lebleu, Bernard; Pfleiderer, Wolfgang; Charubala, Ramamurthy; De
Meirleir, Kenny; De Becker, Pascale; Peterson, Daniel L.; Herst, C.V.T.; Englebienne, Patrick; Suhadolnik, Robert J. (April 2002). "Structural and
408:
Suhadolnik, Robert J.; Reichenbach, Nancy L.; Hitzges, Patricia; Sobol, Robert W.; Peterson, Daniel L.; Henry, Berch; Ablashi, Dharam V.; Müller, Werner E. G.; Schröder, Heinz C.; Carter, William A.; Strayer, David R. (January 1994). "Upregulation of the 2-5A synthetase/RNase L antiviral pathway
436:
Strayer, David R.; Carter, William A.; Brodsky, Isadore; Cheney, Paul; Peterson, Daniel; Salvato, Patricia; Thompson, Carol; Loveless, Mark; Shapiro, David E.; Elsasser, William; Gillespie, David H. (January 1994). "A controlled clinical trial with a specifically configured RNA drug,
175:(HHV-6) associated scientific and clinical research. Peterson was part of the founding board and is a past-president of the International Association for CFS/ME, a professional organization advocating for the interests of ME/CFS researchers and clinicians worldwide.
192:
Lombardi, Vincent C.; Ruscetti, Francis W.; Das Gupta, Jaydip; Pfost, Max A.; Hagen, Kathryn S.; Peterson, Daniel L.; Ruscetti, Sandra K.; Bagni, Rachel K.; Petrow-Sadowski, Cari; Gold, Bert; Dean, Michael; Silverman, Robert H.; Mikovits, Judy A. (October 2009).
334:; Peterson, Daniel L.; O'Brien, Karen; Cheney, Paul R.; Herst, C.V.T.; Reichenbach, Nancy L.; Kon, Ning; Horvath, Susan E.; Iacono, Kathryn T.; Adelson, Martin E.; de Meirleir, Kenny; de Becker, Pascale; Charubala, Ramamurthy; Pfleiderer, Wolfgang (July 1997).
299:
Ablashi, D.V.; Eastman, H.B.; Owen, C.B.; Roman, M.M.; Friedman, J.; Zabriskie, J.B.; Peterson, D.L.; Pearson, G.R.; Whitman, J.E. (May 2000). "Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients".
178:
In 2003, he received the Rudy
Perpich award, an award given to distinguished CFS/FM scientists, physicians or healthcare workers, and in 2007, received the Nelson Gantz Outstanding Clinician Award from the International Association for CFS/ME.
933:
Fukuda, K.; Straus, S.; Hickie, I.; Sharpe, M.; Dobbins, J.; Komaroff, A. (1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International
Chronic Fatigue Syndrome Study Group".
343:
117:
Peterson was a member of the
International Chronic Fatigue Syndrome Study Group that coauthored the most widely used clinical and research description of CFS, called the 1994 CDC definition, and the
809:
Strayer, D.R.; Carter, W.A.; Brodsky, I.; et al. (January 1994). "A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome".
155:
In 2010, Peterson left WPI for personal reasons. He stated there was a lack of collaboration with him over the research direction of the institute concerning XMRV. Peterson then teamed with
491:
Daugherty, Sandra A.; Henry, Berch E.; Peterson, Daniel L.; Swarts, Raymond L.; Bastien, Sheila; Thomas, Robert S. (January–February 1991). "Chronic fatigue syndrome in northern Nevada".
721:
464:
Levine, Paul H.; Peterson, Daniel; McNamee, Faye L.; O'Brien, Karen; Gridley, Gloria; Hagerty, Mary; Brady, Jane; Fears, Thomas; Atherton, Martin; Hoover, Robert (1 October 1992).
114:
for marketing and sale of
Ampligen to treat ME/CFS was rejected in December 2009 because the FDA concluded that the two RCTs "did not provide credible evidence of efficacy."
1386:
159:, one of the original discoverers of HIV, to try to determine whether XMRV is truly present in patients by testing the same patients used in the study published in
1253:
Friedberg, F.; Sohl, S.; Schmeizer, B. (August 2007). "Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995–2004".
1289:
702:
41:
259:
1315:
171:
Peterson is a member of the board of directors and the scientific advisory board of the HHV-6 Foundation, a non-profit organization promoting
1207:
1391:
1020:"Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works"
741:
1093:
590:
45:
182:
In 1999, Peterson was commended by the
Assembly and Senate of the State of Nevada for his work and dedication to persons with ME/CFS.
68:
Along with Paul Cheney, Peterson was a treating physician at
Incline Village during an outbreak of ME/CFS that began in 1984 in the
647:
335:
619:
1366:
1076:
793:
600:
530:
Caligiuri, M.; Murray, C.; Buchwald, D.; Levine, H.; Cheney, P.; Peterson, D.; Komaroff, A. L.; Ritz, J. (15 November 1987).
759:
84:
In 1988, Peterson was the first physician to treat an extremely ill person diagnosed with ME/CFS with the experimental drug
53:
123:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols
722:"Neuromyasthenia and Chronic Fatigue Syndrome (CFS) in Northern Nevada/California: A Ten-Year Follow-Up of an Outbreak"
978:
1371:
979:"Myalgic encephalomyalitis/chronic fatigue syndrome: Clinical working definition, diagnostic and treatment protocols"
89:
49:
97:
months. In 1990 and 1991, Peterson was one of four principal investigators for the FDA approved phase II randomized
862:
20:
1293:
1381:
1287:
David Tuller, "Expert Q&A, Learning Firsthand about Chronic Fatigue Syndrome" Interview with Leonard Jason,
465:
651:
133:
493:
439:
411:
302:
1290:"Chronic Fatigue - Expert Q & A - Learning Firsthand About Chronic Fatigue Syndrome - NY Times Health"
336:"Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome"
532:"Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome"
195:"Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome"
137:
102:
1340:
470:
1319:
1232:
531:
1130:
720:
Strickland, Paula S.; Levine, Paul H.; Peterson, Daniel L.; O'Brien, Karen; Fears, Thomas (2001).
1104:
1376:
947:
145:
93:
1170:
331:
206:
148:
about his views on ME/CFS and the newly published possible association with the retrovirus
111:
818:
506:
448:
420:
8:
680:
172:
81:, Peterson was interviewed about some of his experiences during the Lake Tahoe outbreak.
1174:
655:
368:
210:
1044:
1019:
959:
915:
623:
561:
510:
270:
functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome".
227:
194:
315:
1270:
1266:
1188:
1072:
1049:
951:
907:
902:
885:
822:
789:
596:
553:
518:
479:
452:
424:
396:
360:
319:
287:
251:
232:
919:
565:
247:
1262:
1178:
1039:
1031:
993:
943:
897:
814:
733:
543:
502:
444:
416:
352:
311:
279:
243:
222:
214:
963:
840:
548:
57:
676:
705:, Hillary Johnson, PWC's, Paul Pollard, Mrs. Dailor, Philip Lee (1996-03-27).
283:
1360:
126:
78:
63:
1035:
356:
218:
1274:
1192:
1053:
1001:
911:
323:
291:
255:
236:
141:
118:
110:
III drug study of Ampligen for treatment of ME/CFS. Hemispherx Biopharma's
997:
955:
826:
786:
Osler's web: inside the labyrinth of the chronic fatigue syndrome epidemic
737:
557:
522:
483:
456:
428:
400:
364:
755:
268:
132:
Peterson, along with Annette and Harvey Whittemore, helped establish the
106:
1069:
Practical General Practice: Guidelines for Effective Clinical Management
514:
69:
466:"Does Chronic Fatigue Syndrome Predispose to Non-Hodgkin's Lymphoma?"
48:, Rochester, New York, in 1976 and was an intern and resident at the
33:
30:
1183:
1158:
719:
385:
330:
156:
144:
and related illnesses. In October 2009 Peterson was interviewed on
85:
1205:
407:
98:
1071:(5th New ed.). Elsevier Health Sciences. pp. 419–421.
463:
129:
and published by an international group of researchers in 2003.
37:
191:
73:
the outbreak. The study results were published in 2001 by the
1094:"Daughter's illness led family to seek help, start institute"
529:
490:
40:, and has been described as a "pioneer" in the treatment of
149:
435:
64:
Work in Myalgic encephalomyelitis/chronic fatigue syndrome
1235:. National Institute of Neurological Disorders and Stroke
1206:
Jay A. Levy and Daniel L. Peterson (September 30, 2011).
701:
Sam Donaldson, Nancy Snyderman, Paul Cheney, David Bell,
52:
from 1976 to 1979. In 1979, he became a diplomate of the
932:
863:"FDA rejects Hemispherx's chronic fatigue drug Ampligen"
298:
140:
in 2005 to aid patients with chronic fatigue syndrome,
1318:. International Association for CFS/ME. Archived from
1252:
843:. U.S. National Institutes of Health. September 2005
808:
88:by obtaining compassionate-use permission from the
1387:Myalgic encephalomyelitis/chronic fatigue syndrome
1343:. Nevada Legislative Counsel Bureau. April 8, 1999
1060:
437:poly(I).poly(C12U), in chronic fatigue syndrome".
42:Myalgic encephalomyelitis/chronic fatigue syndrome
1308:
56:. He is president of Sierra Internal Medicine of
1358:
1122:
1152:
1150:
841:"Study of Ampligen in Chronic Fatigue Syndrome"
589:Verrillo, Erica F.; Gellman, Lauren M. (1998).
588:
1281:
1199:
1085:
584:
582:
1246:
1067:Khot, Alex; Polmear, Andrew (24 April 2006).
1011:
854:
802:
344:Journal of Interferon & Cytokine Research
1147:
19:For other people named Daniel Peterson, see
1066:
890:Acta Neurologica Scandinavica. Supplementum
788:. New York: Crown Publishers. p. 385.
592:Chronic Fatigue Syndrome: A Treatment Guide
579:
409:associated with chronic fatigue syndrome".
1017:
976:
166:
46:University of Rochester School of Medicine
1208:"The mystery of chronic fatigue syndrome"
1182:
1043:
901:
886:"The chronic fatigue syndrome--an update"
713:
614:
612:
547:
226:
1156:
1131:"Virus Tied To Chronic Fatigue Syndrome"
1128:
948:10.7326/0003-4819-121-12-199412150-00009
642:
640:
622:. HHV-6 Foundation. 2004. Archived from
185:
926:
833:
783:
1359:
1091:
977:Carruthers, B.M.; et al. (2003).
883:
877:
860:
609:
136:(WPI) for Neuro-Immune Disease at the
1333:
1225:
777:
754:
669:
637:
620:"HHV-6 Foundation Board of Directors"
970:
748:
36:in private practice in the state of
1392:People from Incline Village, Nevada
1129:Montagne, Renee (October 9, 2009).
986:Journal of Chronic Fatigue Syndrome
819:10.1093/clinids/18.supplement_1.s88
726:Journal of Chronic Fatigue Syndrome
507:10.1093/clinids/13.Supplement_1.S39
449:10.1093/clinids/18.Supplement_1.S88
421:10.1093/clinids/18.Supplement_1.S96
75:Journal of Chronic Fatigue Syndrome
54:American Board of Internal Medicine
13:
1092:Powers, Lenita (1 November 2009).
1018:Carruthers, B.M. (February 2007).
694:
14:
1403:
861:George, John (December 3, 2009).
652:The Whittemore Peterson Institute
90:U.S. Food and Drug Administration
50:University of Utah Medical Center
1267:10.1016/j.jpsychores.2007.03.003
1159:"Virology: Fighting for a cause"
1157:Callaway, Ewen (14 March 2011).
903:10.1111/j.1600-0404.2007.00840.x
121:definition. He is a coauthor of
44:(ME/CFS). He graduated from the
21:Daniel Peterson (disambiguation)
865:. Philadelphia Business Journal
248:10.1126/science.334.6063.1636-a
1367:University of Rochester alumni
766:. Roger Ebert Chicago Suntimes
77:. In the 2000 CFS documentary
1:
573:
316:10.1016/S1386-6532(99)00079-7
134:Whittemore Peterson Institute
549:10.4049/jimmunol.139.10.3306
494:Clinical Infectious Diseases
440:Clinical Infectious Diseases
412:Clinical Infectious Diseases
303:Journal of Clinical Virology
7:
10:
1408:
1316:"Former IACFS/ME awardees"
677:"Sierra Internal Medicine"
595:. Macmillan. p. 152.
272:J. Interferon Cytokine Res
105:study of the experimental
18:
784:Johnson, Hillary (1996).
536:The Journal of Immunology
478:(19 Suppl): 55l6s–55l8s.
284:10.1089/10799900252952235
1372:University of Utah staff
415:. 18. Suppl 1: S96–104.
1036:10.1136/jcp.2006.042754
813:. 18. Suppl 1: S88–95.
709:(Television). ABC News.
443:. 18. Suppl 1: S88–95.
357:10.1089/jir.1997.17.377
219:10.1126/science.1179052
167:Affiliations and awards
60:, established in 1981.
1382:Physicians from Nevada
654:. 2008. Archived from
1135:National Public Radio
998:10.1300/J092v11n01_02
884:Wyller, V.B. (2007).
738:10.1300/J092v09n03_02
332:Suhadolnik, Robert J.
242:(Retracted, see
186:Selected publications
146:National Public Radio
1101:Reno Gazette-Journal
758:(December 7, 2001).
681:Dun & Bradstreet
501:(Suppl 1): S39–S44.
138:University of Nevada
112:New Drug Application
1175:2011Natur.471..282C
211:2009Sci...326..585L
173:human herpesvirus 6
1233:"HHV-6 Foundation"
1110:on 2 December 2010
16:American physician
1212:Los Angeles Times
1078:978-0-7506-8867-3
811:Clin. Infect. Dis
795:978-0-517-70353-3
648:"executive staff"
602:978-0-312-18066-9
542:(10): 3306–3313.
205:(5952): 585–589.
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125:, initiated by
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58:Incline Village
27:Daniel Peterson
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1305:April 30, 2008
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896:(s187): 7–14.
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79:I Remember Me
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1345:. Retrieved
1335:
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1320:the original
1310:
1298:. Retrieved
1294:the original
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1261:(2): 143–6.
1258:
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1237:. Retrieved
1227:
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1138:. Retrieved
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1112:. Retrieved
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