1180:
310:
287:
209:
184:
561:
316:
215:
1242:
1.1 are mutated (loss-of-function), reducing the availability of the channel to sense depolarisation, and therefore it cannot activate the ryanodine receptor as efficiently. As a result, the muscle cannot contract very well and the patient is paralysed. The condition is hypokalemic because a low
1251:
more quickly, so any calcium conductance that does occur cannot be sustained. It becomes more difficult to reach the threshold at which the muscle can contract, and even if this is reached then the muscle is more prone to relaxing. Because of this, the severity would be reduced if potassium ion
63:
1934:
Iles DE, Segers B, Olde
Weghuis D, Suijkerbuijk R, Mikala G, Schwartz A, Wieringa B (1994). "Refined localization of the alpha 1-subunit of the skeletal muscle L-type voltage-dependent calcium channel (CACNL1A3) to human chromosome 1q32 by in situ hybridization".
1221:
to the T-tubules. It was previously thought that when the muscle depolarises, the calcium channel opens, allowing calcium in and activating RyR1, which mediates much greater calcium release from the sarcoplasmic reticulum. This is the first part of the process of
1896:
Drouet B, Garcia L, Simon-Chazottes D, Mattei MG, Guénet JL, Schwartz A, Varadi G, Pinçon-Raymond M (1993). "The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32".
1226:, which ultimately causes the muscle to contract. Calcium entry through Cav1.1 is not required in skeletal muscle, as it is in cardiac muscle; Cav1.1 undergoes a conformational change which allosterically activates RyR1.
1725:"Hypokalemic periodic paralysis and the dihydropyridine receptor (CACNL1A3): genotype/phenotype correlations for two predominant mutations and evidence for the absence of a founder effect in 16 caucasian families"
323:
222:
1648:
Tanabe T, Takeshima H, Mikami A, Flockerzi V, Takahashi H, Kangawa K, Kojima M, Matsuo H, Hirose T, Numa S (1987). "Primary structure of the receptor for calcium channel blockers from skeletal muscle".
2073:"Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle"
1179:
1830:
Jurkat-Rott K, Lehmann-Horn F, Elbaz A, Heine R, Gregg RG, Hogan K, Powers PA, Lapie P, Vale-Santos JE, Weissenbach J (1994). "A calcium channel mutation causing hypokalemic periodic paralysis".
1541:
Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (2005). "International Union of
Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels".
2036:
Robinson RL, Monnier N, Wolz W, Jung M, Reis A, Nuernberg G, Curran JL, Monsieurs K, Stieglitz P, Heytens L, Fricker R, van
Broeckhoven C, Deufel T, Hopkins PM, Lunardi J, Mueller CR (1997).
1859:
Ptácek LJ, Tawil R, Griggs RC, Engel AG, Layzer RB, Kwieciński H, McManis PG, Santiago L, Moore M, Fouad G (1994). "Dihydropyridine receptor mutations cause hypokalemic periodic paralysis".
1801:
Gregg RG, Couch F, Hogan K, Powers PA (1993). "Assignment of the human gene for the alpha 1 subunit of the skeletal muscle DHP-sensitive Ca2+ channel (CACNL1A3) to chromosome 1q31-q32".
2007:
Hogan K, Gregg RG, Powers PA (1996). "The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3)".
1580:"Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase"
3123:
1694:
Hogan K, Powers PA, Gregg RG (1994). "Cloning of the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3)".
4033:
3768:
3020:
2953:
839:
145:
820:
2151:"Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H"
1386:
2356:
1368:
2307:
1966:"Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia"
1051:
1058:
2196:"Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle"
1758:
Boerman RH, Ophoff RA, Links TP, van Eijk R, Sandkuijl LA, Elbaz A, Vale-Santos JE, Wintzen AR, van
Deutekom JC, Isles DE (1995).
3964:
3947:
3942:
3937:
3932:
2245:
Carsana A, Fortunato G, De Sarno C, Brancadoro V, Salvatore F (2003). "Identification of new polymorphisms in the CACNA1S gene".
1407:
3969:
3067:
2339:
1615:"cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers"
1511:
1351:
1256:
refers to gain-of-function mutations in sodium channels that maintain muscle depolarisation and therefore are aggravated by
4570:
4021:
3202:
60:
3919:
2940:
1330:
3705:
1423:"Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop"
1190:
116:, CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP, calcium voltage-gated channel subunit alpha1 S, DHPR
309:
1723:
Elbaz A, Vale-Santos J, Jurkat-Rott K, Lapie P, Ophoff RA, Bady B, Links TP, Piussan C, Vila A, Monnier N (1995).
4298:
3297:
3075:
2391:
1760:"Mutation in DHP receptor alpha 1 subunit (CACLN1A3) gene in a Dutch family with hypokalaemic periodic paralysis"
1355:
1334:
1253:
1223:
286:
4320:
1235:
1164:
884:
4529:
2440:
1168:
865:
3895:
2807:
208:
183:
125:
17:
322:
221:
4170:
2289:
315:
214:
2348:
2332:
4524:
2734:
2294:
112:
4514:
2775:
2651:
2317:
2298:
1034:
1026:
975:
133:
4519:
2038:"A genome wide search for susceptibility loci in three European malignant hyperthermia pedigrees"
1030:
1005:
979:
954:
4550:
2542:
2529:
2516:
2496:
2483:
2448:
1301:
1264:
1206:
1172:
1156:
4575:
2325:
153:
2423:
2207:
2116:"Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels"
1658:
197:
1964:
O'Brien RO, Taske NL, Hansbro PM, Matthaei KI, Hogan SP, Denborough MA, Foster PS (1995).
8:
1214:
2211:
1662:
3890:
2766:
2413:
2270:
2228:
2195:
2177:
2167:
2150:
2097:
2072:
1990:
1965:
1922:
1884:
1784:
1759:
1741:
1724:
1682:
1566:
1488:
1463:
1306:
1210:
1202:
157:
2219:
1631:
1614:
1596:
1579:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
658:
653:
637:
632:
627:
622:
617:
612:
607:
602:
2928:
2262:
2233:
2182:
2137:
2102:
2059:
2024:
1995:
1952:
1914:
1876:
1872:
1847:
1818:
1789:
1746:
1711:
1674:
1636:
1601:
1558:
1493:
1444:
1248:
1194:
105:
53:
2274:
1888:
1570:
3697:
2678:
2254:
2223:
2215:
2172:
2162:
2127:
2092:
2084:
2049:
2016:
1985:
1977:
1944:
1926:
1906:
1868:
1839:
1810:
1779:
1771:
1736:
1703:
1686:
1666:
1626:
1591:
1550:
1483:
1475:
1434:
1408:"Entrez Gene: CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit"
1218:
402:
333:
277:
232:
1515:
137:
4233:
2373:
1296:
1284:
1280:
1267:
Group accepts two mutations in CACNA1S as diagnostic for malignant hyperthermia.
1198:
1160:
1142:
377:
161:
1391:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1373:
National Center for
Biotechnology Information, U.S. National Library of Medicine
560:
4029:
2716:
2194:
Protasi F, Paolini C, Nakai J, Beam KG, Franzini-Armstrong C, Allen PD (2002).
1421:
Proenza C, O'Brien J, Nakai J, Mukherjee S, Allen PD, Beam KG (February 2002).
478:
1464:"Muscle channelopathies and critical points in functional and genetic studies"
4564:
3983:
3656:
2311:
2132:
2115:
589:
4016:
3914:
538:
416:
4336:
3727:
2266:
2237:
2020:
1948:
1843:
1814:
1707:
1562:
1497:
1448:
1439:
1422:
395:
174:
2258:
2186:
2141:
2114:
Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, Fishman GI (1998).
2106:
2063:
2054:
2037:
2028:
1999:
1981:
1956:
1918:
1880:
1851:
1822:
1793:
1750:
1715:
1678:
1640:
1605:
1098:
1093:
4266:
4261:
4256:
4251:
4138:
3977:
2352:
929:
910:
1775:
4246:
3612:
2980:
2948:
1910:
294:
191:
141:
2290:
GeneReviews/NCBI/NIH/UW entry on
Malignant Hyperthermia Susceptibility
1554:
1155:
This gene encodes one of the five subunits of the slowly inactivating
82:
4331:
4241:
1670:
1504:
1479:
784:
361:
348:
260:
247:
149:
2347:
1540:
4344:
3692:
2671:
2666:
2661:
2656:
2588:
2583:
2088:
1613:
Röhrkasten A, Meyer HE, Nastainczyk W, Sieber M, Hofmann F (1988).
1082:
2244:
1933:
4471:
4228:
4064:
2565:
2560:
2555:
1895:
1829:
1126:
896:
851:
769:
765:
2070:
1722:
1612:
1420:
129:
4148:
4143:
3877:
3872:
3818:
3813:
3629:
3617:
3607:
3602:
3590:
3585:
3580:
3467:
3462:
3457:
3349:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3190:
3185:
3175:
3170:
3165:
3116:
3111:
3101:
3096:
2973:
2968:
2963:
2958:
2864:
2859:
2854:
2844:
2839:
2829:
2824:
2754:
2749:
2744:
2739:
2642:
2637:
2632:
2627:
2615:
2610:
2605:
2600:
2509:
2476:
2471:
2466:
1963:
1066:
806:
1647:
1578:
Rotman EI, De Jongh KS, Florio V, Lai Y, Catterall WA (1992).
1217:
from nervous stimulation and propagated by sodium channels as
569:
4382:
4313:
4308:
4303:
4220:
4207:
4202:
4197:
4192:
4187:
4182:
4133:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4079:
4074:
4069:
4059:
4054:
4049:
4044:
3959:
3903:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3759:
3754:
3749:
3744:
3732:
3649:
3644:
3639:
3624:
3562:
3557:
3552:
3543:
3538:
3524:
3519:
3510:
3505:
3500:
3491:
3486:
3477:
3472:
3439:
3434:
3429:
3424:
3415:
3406:
3401:
3396:
3387:
3382:
3377:
3372:
3363:
3358:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3180:
3150:
3145:
3140:
3135:
3106:
3055:
3050:
3045:
3040:
3030:
3025:
3005:
2990:
2985:
2900:
2895:
2890:
2885:
2869:
2849:
2834:
2795:
2790:
2785:
2780:
2688:
2683:
2406:
2401:
2396:
1119:
calcium channel, voltage-dependent, L type, alpha 1S subunit
4462:
4457:
4452:
4442:
4437:
4432:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4377:
4372:
4367:
4362:
4357:
4352:
4291:
4286:
4281:
4276:
4271:
4177:
4165:
4160:
4155:
4086:
4039:
4003:
3998:
3993:
3988:
3715:
3533:
3091:
2428:
2418:
1147:(DHPR, so named due to the blocking action DHP has on it).
1133:
1757:
1512:"European Malignant Hyperthermia Group: Mutations in RYR1"
3035:
2995:
1247:
concentration will cause the muscle to repolarise to the
1244:
1163:
cells. Mutations in this gene have been associated with
385:
2193:
2071:
Monnier N, Procaccio V, Stieglitz P, Lunardi J (1997).
2035:
1577:
1461:
1858:
1800:
1238:(HOKPP), the voltage sensors in domains 2 and 4 of Ca
550:
2148:
2113:
1347:
1345:
1343:
1326:
1324:
1322:
332:
231:
4562:
4505:
2006:
1693:
1340:
1319:
715:membrane depolarization during action potential
1352:GRCm38: Ensembl release 89: ENSMUSG00000026407
2333:
1462:Jurkat-Rott K, Lehmann-Horn F (August 2005).
1252:concentrations are maintained. In contrast,
684:L-type voltage-gated calcium channel complex
1455:
1414:
1331:GRCh38: Ensembl release 89: ENSG00000081248
623:high voltage-gated calcium channel activity
2340:
2326:
2308:United States National Library of Medicine
443:Skeletal muscle tissue of rectus abdominis
2924:
2369:
2297:at the U.S. National Library of Medicine
2227:
2176:
2166:
2131:
2096:
2053:
1989:
1783:
1740:
1630:
1595:
1487:
1438:
720:regulation of ion transmembrane transport
2306:This article incorporates text from the
2149:Morrill JA, Brown RH, Cannon SC (1998).
1402:
1400:
1229:
1209:via a mechanical linkage. It senses the
451:Skeletal muscle tissue of biceps brachii
4493:
2712:
14:
4563:
603:voltage-gated calcium channel activity
4492:
3677:
2923:
2711:
2368:
2321:
1397:
1159:voltage-dependent calcium channel in
659:voltage-gated calcium channel complex
337:
298:
293:
236:
195:
190:
3706:Calcium-activated chloride channels
730:calcium ion transmembrane transport
509:medial head of gastrocnemius muscle
24:
2776:Amiloride-sensitive cation channel
2168:10.1523/JNEUROSCI.18-24-10320.1998
1533:
1129:which in humans is encoded by the
618:voltage-gated ion channel activity
25:
4587:
3678:
2283:
1191:voltage-dependent calcium channel
29:Mammalian protein found in humans
1178:
559:
493:extensor digitorum longus muscle
321:
314:
308:
285:
220:
213:
207:
182:
4299:Voltage-dependent anion channel
2392:Inositol trisphosphate receptor
1254:hyperkalemic periodic paralysis
1224:excitation-contraction coupling
4321:General bacterial porin family
1379:
1361:
1260:potassium ion concentrations.
1236:hypokalemic periodic paralysis
1165:hypokalemic periodic paralysis
664:integral component of membrane
570:More reference expression data
539:More reference expression data
13:
1:
2220:10.1016/S0006-3495(02)75325-3
1632:10.1016/S0021-9258(19)37591-X
1597:10.1016/S0021-9258(18)41972-2
1312:
1169:thyrotoxic periodic paralysis
745:cellular response to caffeine
306:
205:
1873:10.1016/0092-8674(94)90135-X
7:
4571:Genes on human chromosome 1
1290:
1270:
1150:
10:
4592:
3740:Chloride Channel Accessory
2349:Membrane transport protein
517:sternocleidomastoid muscle
4546:
4501:
4488:
4329:
4218:
4014:
3912:
3888:
3690:
3686:
3673:
3296:
3201:
3066:
2939:
2935:
2919:
2806:
2765:
2735:Epithelial sodium channel
2727:
2723:
2707:
2439:
2384:
2380:
2364:
1387:"Mouse PubMed Reference:"
1369:"Human PubMed Reference:"
1097:
1092:
1088:
1081:
1065:
1059:Chr 1: 135.98 – 136.05 Mb
1052:Chr 1: 201.04 – 201.11 Mb
1046:
1023:
1019:
1002:
998:
991:
972:
968:
951:
947:
940:
927:
923:
908:
904:
895:
882:
878:
863:
859:
850:
837:
833:
818:
814:
805:
790:
783:
779:
763:
588:
584:
567:
558:
549:
536:
521:quadriceps femoris muscle
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
79:
74:
57:
52:
47:
43:
39:
34:
2652:Cation channels of sperm
2299:Medical Subject Headings
2133:10.1074/jbc.273.30.18930
1243:extracellular potassium
608:calcium channel activity
463:tibialis anterior muscle
1201:it associates with the
735:transmembrane transport
439:vastus lateralis muscle
2295:CACNA1S+protein,+human
2021:10.1006/geno.1996.0066
1949:10.1006/geno.1994.1106
1815:10.1006/geno.1993.1017
1708:10.1006/geno.1994.1677
1440:10.1074/jbc.M106471200
1302:Neuromuscular junction
1265:Malignant Hyperthermia
1207:sarcoplasmic reticulum
1173:malignant hyperthermia
1136:. It is also known as
525:skeletal muscle tissue
501:triceps brachii muscle
435:triceps brachii muscle
2728:Constitutively active
2259:10.1515/CCLM.2003.004
1982:10.1136/jmg.32.11.913
1230:Clinical significance
1213:change caused by the
740:calcium ion transport
2247:Clin. Chem. Lab. Med
1844:10.1093/hmg/3.8.1415
628:ion channel activity
455:gastrocnemius muscle
339:1 E4|1 59.55 cM
300:Chromosome 1 (mouse)
198:Chromosome 1 (human)
75:List of PDB id codes
48:Available structures
4495:By gating mechanism
2212:2002BpJ....83.3230P
2055:10.1093/hmg/6.6.953
1776:10.1136/jmg.32.1.44
1663:1987Natur.328..313T
1215:end-plate potential
162:CACNA1S - orthologs
4022:TRP cation channel
3920:CNG cation channel
3203:Tandem pore domain
2414:Ryanodine receptor
2310:, which is in the
1911:10.1007/BF00364784
1307:Ryanodine receptor
1203:ryanodine receptor
1117:also known as the
885:ENSMUSG00000026407
755:cardiac conduction
750:calcium ion import
710:muscle contraction
703:Biological process
647:Cellular component
638:calmodulin binding
596:Molecular function
447:thoracic diaphragm
4558:
4557:
4542:
4541:
4538:
4537:
4530:Stretch-activated
4507:Ion channel class
4484:
4483:
4480:
4479:
3669:
3668:
3665:
3664:
2941:Calcium-activated
2929:Potassium channel
2915:
2914:
2911:
2910:
2703:
2702:
2699:
2698:
2077:Am. J. Hum. Genet
1729:Am. J. Hum. Genet
1555:10.1124/pr.57.4.5
1249:resting potential
1219:action potentials
1195:transverse tubule
1108:
1107:
1104:
1103:
1077:
1076:
1042:
1041:
1013:
1012:
987:
986:
962:
961:
936:
935:
917:
916:
891:
890:
872:
871:
846:
845:
827:
826:
775:
774:
613:metal ion binding
580:
579:
576:
575:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
94:
93:
90:
89:
58:Ortholog search:
16:(Redirected from
4583:
4503:
4502:
4490:
4489:
3698:Chloride channel
3688:
3687:
3675:
3674:
3068:Inward-rectifier
2937:
2936:
2921:
2920:
2725:
2724:
2709:
2708:
2679:Two-pore channel
2382:
2381:
2366:
2365:
2342:
2335:
2328:
2319:
2318:
2278:
2241:
2231:
2190:
2180:
2170:
2161:(24): 10320–34.
2145:
2135:
2110:
2100:
2067:
2057:
2032:
2003:
1993:
1960:
1930:
1892:
1855:
1826:
1797:
1787:
1754:
1744:
1719:
1690:
1671:10.1038/328313a0
1644:
1634:
1609:
1599:
1574:
1527:
1526:
1524:
1523:
1514:. Archived from
1508:
1502:
1501:
1491:
1480:10.1172/JCI25525
1459:
1453:
1452:
1442:
1418:
1412:
1411:
1404:
1395:
1394:
1383:
1377:
1376:
1365:
1359:
1349:
1338:
1328:
1182:
1175:susceptibility.
1090:
1089:
1061:
1054:
1037:
1017:
1016:
1008:
996:
995:
992:RefSeq (protein)
982:
966:
965:
957:
945:
944:
921:
920:
902:
901:
876:
875:
857:
856:
831:
830:
812:
811:
781:
780:
586:
585:
572:
563:
556:
555:
541:
497:plantaris muscle
481:
479:Top expressed in
474:
473:
419:
417:Top expressed in
412:
411:
391:
390:
374:
373:
364:
351:
340:
325:
318:
312:
301:
289:
273:
272:
263:
250:
239:
224:
217:
211:
200:
186:
170:
169:
164:
115:
108:
85:
72:
71:
66:
45:
44:
32:
31:
21:
4591:
4590:
4586:
4585:
4584:
4582:
4581:
4580:
4561:
4560:
4559:
4554:
4534:
4497:
4476:
4325:
4224:
4214:
4010:
3908:
3884:
3682:
3661:
3575:
3452:
3309:
3292:
3197:
3161:
3131:
3087:
3079:
3062:
3016:
2931:
2907:
2880:
2819:
2802:
2761:
2719:
2695:
2578:
2550:
2537:
2524:
2504:
2491:
2456:
2435:
2376:
2374:Calcium channel
2360:
2346:
2286:
2281:
2126:(30): 18930–5.
2042:Hum. Mol. Genet
1832:Hum. Mol. Genet
1657:(6128): 313–8.
1625:(30): 15325–9.
1590:(23): 16100–5.
1536:
1534:Further reading
1531:
1530:
1521:
1519:
1510:
1509:
1505:
1468:J. Clin. Invest
1460:
1456:
1419:
1415:
1406:
1405:
1398:
1385:
1384:
1380:
1367:
1366:
1362:
1350:
1341:
1329:
1320:
1315:
1297:Calcium channel
1293:
1285:dihydropyridine
1278:
1273:
1241:
1232:
1199:skeletal muscle
1197:of muscles. In
1188:
1161:skeletal muscle
1153:
1143:dihydropyridine
1114:
1099:View/Edit Mouse
1094:View/Edit Human
1057:
1050:
1047:Location (UCSC)
1033:
1029:
1025:
1004:
978:
974:
953:
866:ENSG00000081248
759:
698:
689:plasma membrane
642:
633:protein binding
568:
537:
528:
523:
519:
515:
513:temporal muscle
511:
507:
503:
499:
495:
491:
489:muscle of thigh
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
431:muscle of thigh
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
81:
59:
30:
23:
22:
15:
12:
11:
5:
4589:
4579:
4578:
4573:
4556:
4555:
4547:
4544:
4543:
4540:
4539:
4536:
4535:
4533:
4532:
4527:
4522:
4517:
4511:
4509:
4499:
4498:
4486:
4485:
4482:
4481:
4478:
4477:
4475:
4474:
4469:
4468:
4467:
4466:
4465:
4460:
4455:
4447:
4446:
4445:
4440:
4435:
4427:
4426:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4387:
4386:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4341:
4339:
4327:
4326:
4324:
4323:
4318:
4317:
4316:
4311:
4306:
4296:
4295:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4249:
4238:
4236:
4222:
4216:
4215:
4213:
4212:
4211:
4210:
4205:
4200:
4195:
4190:
4185:
4175:
4174:
4173:
4168:
4158:
4153:
4152:
4151:
4146:
4141:
4131:
4130:
4129:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4084:
4083:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4037:
4026:
4024:
4012:
4011:
4009:
4008:
4007:
4006:
4001:
3996:
3991:
3986:
3974:
3973:
3972:
3967:
3962:
3952:
3951:
3950:
3945:
3940:
3935:
3924:
3922:
3910:
3909:
3907:
3906:
3900:
3898:
3896:Proton channel
3886:
3885:
3883:
3882:
3881:
3880:
3875:
3865:
3864:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3823:
3822:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3771:
3766:
3765:
3764:
3763:
3762:
3757:
3752:
3747:
3737:
3736:
3735:
3730:
3720:
3719:
3718:
3702:
3700:
3684:
3683:
3671:
3670:
3667:
3666:
3663:
3662:
3660:
3659:
3654:
3653:
3652:
3647:
3642:
3632:
3627:
3622:
3621:
3620:
3615:
3610:
3605:
3595:
3594:
3593:
3588:
3583:
3573:
3568:
3567:
3566:
3565:
3560:
3555:
3548:
3547:
3546:
3541:
3536:
3529:
3528:
3527:
3522:
3515:
3514:
3513:
3508:
3503:
3496:
3495:
3494:
3489:
3482:
3481:
3480:
3475:
3470:
3465:
3460:
3450:
3445:
3444:
3443:
3442:
3437:
3432:
3427:
3420:
3419:
3418:
3411:
3410:
3409:
3404:
3399:
3392:
3391:
3390:
3385:
3380:
3375:
3368:
3367:
3366:
3361:
3354:
3353:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3307:
3302:
3300:
3294:
3293:
3291:
3290:
3289:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3218:
3207:
3205:
3199:
3198:
3196:
3195:
3194:
3193:
3188:
3183:
3178:
3173:
3168:
3159:
3155:
3154:
3153:
3148:
3143:
3138:
3129:
3121:
3120:
3119:
3114:
3109:
3104:
3099:
3094:
3085:
3081:
3077:
3072:
3070:
3064:
3063:
3061:
3060:
3059:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3014:
3010:
3009:
3008:
3000:
2999:
2998:
2993:
2988:
2978:
2977:
2976:
2971:
2966:
2961:
2956:
2945:
2943:
2933:
2932:
2917:
2916:
2913:
2912:
2909:
2908:
2906:
2905:
2904:
2903:
2898:
2893:
2888:
2878:
2874:
2873:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2817:
2812:
2810:
2804:
2803:
2801:
2800:
2799:
2798:
2793:
2788:
2783:
2772:
2770:
2763:
2762:
2760:
2759:
2758:
2757:
2752:
2747:
2742:
2731:
2729:
2721:
2720:
2717:Sodium channel
2705:
2704:
2701:
2700:
2697:
2696:
2694:
2693:
2692:
2691:
2686:
2676:
2675:
2674:
2669:
2664:
2659:
2648:
2647:
2646:
2645:
2640:
2635:
2630:
2620:
2619:
2618:
2613:
2608:
2603:
2593:
2592:
2591:
2586:
2576:
2571:
2570:
2569:
2568:
2563:
2558:
2548:
2540:
2535:
2527:
2522:
2514:
2513:
2512:
2502:
2494:
2489:
2481:
2480:
2479:
2474:
2469:
2464:
2454:
2445:
2443:
2437:
2436:
2434:
2433:
2432:
2431:
2426:
2421:
2411:
2410:
2409:
2404:
2399:
2388:
2386:
2378:
2377:
2362:
2361:
2345:
2344:
2337:
2330:
2322:
2303:
2302:
2292:
2285:
2284:External links
2282:
2280:
2279:
2242:
2206:(6): 3230–44.
2191:
2146:
2111:
2089:10.1086/515454
2083:(6): 1316–25.
2068:
2033:
2004:
1961:
1931:
1905:(9): 499–503.
1893:
1856:
1827:
1798:
1755:
1720:
1691:
1645:
1610:
1575:
1543:Pharmacol. Rev
1537:
1535:
1532:
1529:
1528:
1503:
1454:
1413:
1396:
1378:
1360:
1339:
1317:
1316:
1314:
1311:
1310:
1309:
1304:
1299:
1292:
1289:
1276:
1272:
1269:
1239:
1231:
1228:
1186:
1152:
1149:
1112:
1106:
1105:
1102:
1101:
1096:
1086:
1085:
1079:
1078:
1075:
1074:
1072:
1070:
1063:
1062:
1055:
1048:
1044:
1043:
1040:
1039:
1021:
1020:
1014:
1011:
1010:
1000:
999:
993:
989:
988:
985:
984:
970:
969:
963:
960:
959:
949:
948:
942:
938:
937:
934:
933:
925:
924:
918:
915:
914:
906:
905:
899:
893:
892:
889:
888:
880:
879:
873:
870:
869:
861:
860:
854:
848:
847:
844:
843:
835:
834:
828:
825:
824:
816:
815:
809:
803:
802:
797:
792:
788:
787:
777:
776:
773:
772:
761:
760:
758:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
661:
656:
650:
648:
644:
643:
641:
640:
635:
630:
625:
620:
615:
610:
605:
599:
597:
593:
592:
582:
581:
578:
577:
574:
573:
565:
564:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
459:deltoid muscle
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
28:
9:
6:
4:
3:
2:
4588:
4577:
4574:
4572:
4569:
4568:
4566:
4553:
4552:
4545:
4531:
4528:
4526:
4525:Voltage-gated
4523:
4521:
4518:
4516:
4513:
4512:
4510:
4508:
4504:
4500:
4496:
4491:
4487:
4473:
4470:
4464:
4461:
4459:
4456:
4454:
4451:
4450:
4448:
4444:
4441:
4439:
4436:
4434:
4431:
4430:
4428:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4390:
4388:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4350:
4348:
4347:
4346:
4343:
4342:
4340:
4338:
4335:
4333:
4328:
4322:
4319:
4315:
4312:
4310:
4307:
4305:
4302:
4301:
4300:
4297:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4244:
4243:
4240:
4239:
4237:
4235:
4232:
4230:
4226:
4217:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4180:
4179:
4176:
4172:
4169:
4167:
4164:
4163:
4162:
4159:
4157:
4154:
4150:
4147:
4145:
4142:
4140:
4137:
4136:
4135:
4132:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4089:
4088:
4085:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4042:
4041:
4038:
4035:
4031:
4028:
4027:
4025:
4023:
4020:
4018:
4013:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3981:
3980:
3979:
3975:
3971:
3968:
3966:
3963:
3961:
3958:
3957:
3956:
3953:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3930:
3929:
3926:
3925:
3923:
3921:
3918:
3916:
3911:
3905:
3902:
3901:
3899:
3897:
3894:
3892:
3887:
3879:
3876:
3874:
3871:
3870:
3869:
3866:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3828:
3827:
3824:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3776:
3775:
3772:
3770:
3767:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3734:
3731:
3729:
3726:
3725:
3724:
3721:
3717:
3714:
3713:
3712:
3709:
3708:
3707:
3704:
3703:
3701:
3699:
3696:
3694:
3689:
3685:
3681:
3680:Miscellaneous
3676:
3672:
3658:
3657:Shaker (gene)
3655:
3651:
3648:
3646:
3643:
3641:
3638:
3637:
3636:
3633:
3631:
3630:minK/ISK-like
3628:
3626:
3623:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3600:
3599:
3596:
3592:
3589:
3587:
3584:
3582:
3579:
3578:
3577:
3570:
3569:
3564:
3561:
3559:
3556:
3554:
3551:
3550:
3549:
3545:
3542:
3540:
3537:
3535:
3532:
3531:
3530:
3526:
3523:
3521:
3518:
3517:
3516:
3512:
3509:
3507:
3504:
3502:
3499:
3498:
3497:
3493:
3490:
3488:
3485:
3484:
3483:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3455:
3454:
3447:
3446:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3422:
3421:
3417:
3414:
3413:
3412:
3408:
3405:
3403:
3400:
3398:
3395:
3394:
3393:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3370:
3369:
3365:
3362:
3360:
3357:
3356:
3355:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3312:
3311:
3304:
3303:
3301:
3299:
3298:Voltage-gated
3295:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3213:
3212:
3209:
3208:
3206:
3204:
3200:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3163:
3162:
3156:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3133:
3132:
3125:
3122:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3089:
3088:
3082:
3080:
3074:
3073:
3071:
3069:
3065:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3018:
3017:
3011:
3007:
3004:
3003:
3001:
2997:
2994:
2992:
2989:
2987:
2984:
2983:
2982:
2979:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2951:
2950:
2947:
2946:
2944:
2942:
2938:
2934:
2930:
2927:
2922:
2918:
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2899:
2897:
2894:
2892:
2889:
2887:
2884:
2883:
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2868:
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2853:
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2836:
2833:
2831:
2828:
2826:
2823:
2822:
2821:
2814:
2813:
2811:
2809:
2808:Voltage-gated
2805:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2778:
2777:
2774:
2773:
2771:
2768:
2764:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2737:
2736:
2733:
2732:
2730:
2726:
2722:
2718:
2715:
2710:
2706:
2690:
2687:
2685:
2682:
2681:
2680:
2677:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2654:
2653:
2650:
2649:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2625:
2624:
2621:
2617:
2614:
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2607:
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2441:Voltage-gated
2438:
2430:
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2425:
2422:
2420:
2417:
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2350:
2343:
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2336:
2331:
2329:
2324:
2323:
2320:
2316:
2315:
2313:
2312:public domain
2309:
2300:
2296:
2293:
2291:
2288:
2287:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2248:
2243:
2239:
2235:
2230:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2197:
2192:
2188:
2184:
2179:
2174:
2169:
2164:
2160:
2156:
2152:
2147:
2143:
2139:
2134:
2129:
2125:
2121:
2120:J. Biol. Chem
2117:
2112:
2108:
2104:
2099:
2094:
2090:
2086:
2082:
2078:
2074:
2069:
2065:
2061:
2056:
2051:
2048:(6): 953–61.
2047:
2043:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2010:
2005:
2001:
1997:
1992:
1987:
1983:
1979:
1976:(11): 913–4.
1975:
1971:
1970:J. Med. Genet
1967:
1962:
1958:
1954:
1950:
1946:
1942:
1938:
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1857:
1853:
1849:
1845:
1841:
1838:(8): 1415–9.
1837:
1833:
1828:
1824:
1820:
1816:
1812:
1809:(1): 107–12.
1808:
1804:
1799:
1795:
1791:
1786:
1781:
1777:
1773:
1769:
1765:
1764:J. Med. Genet
1761:
1756:
1752:
1748:
1743:
1738:
1735:(2): 374–80.
1734:
1730:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1646:
1642:
1638:
1633:
1628:
1624:
1620:
1619:J. Biol. Chem
1616:
1611:
1607:
1603:
1598:
1593:
1589:
1585:
1584:J. Biol. Chem
1581:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1549:(4): 411–25.
1548:
1544:
1539:
1538:
1518:on 2016-03-21
1517:
1513:
1507:
1499:
1495:
1490:
1485:
1481:
1477:
1474:(8): 2000–9.
1473:
1469:
1465:
1458:
1450:
1446:
1441:
1436:
1433:(8): 6530–5.
1432:
1428:
1427:J. Biol. Chem
1424:
1417:
1409:
1403:
1401:
1392:
1388:
1382:
1374:
1370:
1364:
1357:
1353:
1348:
1346:
1344:
1336:
1332:
1327:
1325:
1323:
1318:
1308:
1305:
1303:
1300:
1298:
1295:
1294:
1288:
1286:
1282:
1268:
1266:
1263:The European
1261:
1259:
1255:
1250:
1246:
1237:
1227:
1225:
1220:
1216:
1212:
1208:
1204:
1200:
1196:
1193:found in the
1192:
1183:
1181:
1176:
1174:
1170:
1166:
1162:
1158:
1148:
1146:
1144:
1139:
1135:
1132:
1128:
1124:
1120:
1116:
1100:
1095:
1091:
1087:
1084:
1080:
1073:
1071:
1068:
1064:
1060:
1056:
1053:
1049:
1045:
1038:
1036:
1032:
1028:
1022:
1018:
1015:
1009:
1007:
1001:
997:
994:
990:
983:
981:
977:
971:
967:
964:
958:
956:
950:
946:
943:
941:RefSeq (mRNA)
939:
932:
931:
926:
922:
919:
913:
912:
907:
903:
900:
898:
894:
887:
886:
881:
877:
874:
868:
867:
862:
858:
855:
853:
849:
842:
841:
836:
832:
829:
823:
822:
817:
813:
810:
808:
804:
801:
798:
796:
793:
789:
786:
782:
778:
771:
767:
762:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
725:ion transport
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
591:
590:Gene ontology
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
27:
19:
4576:Ion channels
4548:
4515:Ligand-gated
4506:
4494:
4337:Gap junction
4330:
4219:
4015:
3976:
3954:
3927:
3913:
3889:
3867:
3825:
3773:
3739:
3722:
3710:
3691:
3679:
3634:
3597:
3571:
3448:
3305:
3210:
3157:
3127:
3083:
3012:
2925:
2876:
2815:
2713:
2622:
2595:
2574:
2546:
2533:
2520:
2500:
2487:
2461:
2452:
2385:Ligand-gated
2370:
2353:ion channels
2305:
2304:
2250:
2246:
2203:
2199:
2158:
2154:
2123:
2119:
2080:
2076:
2045:
2041:
2015:(3): 392–4.
2012:
2008:
1973:
1969:
1943:(3): 561–3.
1940:
1936:
1902:
1899:Mamm. Genome
1898:
1867:(6): 863–8.
1864:
1860:
1835:
1831:
1806:
1802:
1767:
1763:
1732:
1728:
1702:(3): 608–9.
1699:
1695:
1654:
1650:
1622:
1618:
1587:
1583:
1546:
1542:
1520:. Retrieved
1516:the original
1506:
1471:
1467:
1457:
1430:
1426:
1416:
1390:
1381:
1372:
1363:
1274:
1262:
1257:
1233:
1205:RyR1 of the
1184:
1177:
1154:
1141:
1137:
1130:
1122:
1118:
1110:
1109:
1035:NP_001389878
1027:NP_001074492
1024:
1003:
976:NM_001081023
973:
952:
928:
909:
883:
864:
838:
819:
799:
794:
401:
394:
360:136,047,560
347:135,980,488
259:201,112,451
246:201,039,512
121:External IDs
80:
26:
18:DHP receptor
4520:Light-gated
3002:IK channel
2253:(1): 20–2.
2155:J. Neurosci
1770:(1): 44–7.
99:Identifiers
4565:Categories
3723:Bestrophin
2981:SK channel
2949:BK channel
2623:γ-subunits
2596:β-subunits
2579:δ-subunits
2200:Biophys. J
1522:2015-05-14
1358:, May 2017
1337:, May 2017
1313:References
694:sarcolemma
405:(ortholog)
142:HomoloGene
4551:disorders
4549:see also
4332:Cytoplasm
4242:Aquaporin
3711:Anoctamin
3534:11.1/hERG
1189:1.1 is a
1031:NP_055008
1006:NP_000060
980:NM_014193
955:NM_000069
785:Orthologs
654:cytoplasm
150:GeneCards
4345:Connexin
3625:minK/ISK
2275:20811090
2267:12636044
2238:12496092
2009:Genomics
1937:Genomics
1889:13538157
1803:Genomics
1696:Genomics
1571:10386627
1563:16382099
1498:16075040
1449:11726651
1354:–
1333:–
1291:See also
1271:Blockers
1151:Function
1145:receptor
1140:and the
1138:CACNL1A3
1125:), is a
1083:Wikidata
764:Sources:
679:T-tubule
669:membrane
4472:Innexin
4229:solutes
2229:1302400
2208:Bibcode
2187:9852570
2178:6793372
2142:9668070
2107:9199552
2098:1716149
2064:9175745
2029:8838325
2000:8592342
1991:1051750
1957:8188298
1927:1386074
1919:8118099
1881:8004673
1852:7987325
1823:7916735
1794:7897626
1785:1050178
1751:7847370
1742:1801148
1716:7713519
1687:4325355
1679:3037387
1659:Bibcode
1641:2844809
1606:1322891
1489:1180551
1356:Ensembl
1335:Ensembl
1281:blocked
1279:1.1 is
1211:voltage
1131:CACNA1S
1127:protein
1123:CACNA1S
897:UniProt
852:Ensembl
791:Species
770:QuickGO
380:pattern
154:CACNA1S
113:CACNA1S
106:Aliases
35:CACNA1S
2769:-gated
2767:Proton
2543:T-type
2530:R-type
2517:Q-type
2497:P-type
2484:N-type
2449:L-type
2301:(MeSH)
2273:
2265:
2236:
2226:
2185:
2175:
2140:
2105:
2095:
2062:
2027:
1998:
1988:
1955:
1925:
1917:
1887:
1879:
1850:
1821:
1792:
1782:
1749:
1739:
1714:
1685:
1677:
1651:Nature
1639:
1604:
1569:
1561:
1496:
1486:
1447:
1157:L-type
1069:search
1067:PubMed
930:Q02789
911:Q13698
807:Entrez
674:I band
551:BioGPS
427:glutes
238:1q32.1
130:114208
4383:GJA10
4234:Porin
4134:TRPML
3904:HVCN1
3598:KCNIP
3453:α7-12
2357:TC 1A
2271:S2CID
1923:S2CID
1885:S2CID
1683:S2CID
1567:S2CID
840:12292
800:Mouse
795:Human
766:Amigo
505:ankle
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
146:37257
138:88294
4463:GJD4
4458:GJD3
4453:GJD2
4443:GJC3
4438:GJC2
4433:GJC1
4423:GJB7
4418:GJB6
4413:GJB5
4408:GJB4
4403:GJB3
4398:GJB2
4393:GJB1
4378:GJA9
4373:GJA8
4368:GJA5
4363:GJA4
4358:GJA3
4353:GJA1
4178:TRPV
4161:TRPP
4156:TRPN
4087:TRPM
4040:TRPC
4030:TRPA
3868:CLNS
3826:CLIC
3774:CLCN
3769:CFTR
3716:ANO1
3635:MiRP
3563:12.3
3558:12.2
3553:12.1
3544:11.3
3539:11.2
3525:10.2
3520:10.1
3310:α1-6
3124:GIRK
2538:α2.3
2525:α2.1
2492:α2.2
2263:PMID
2234:PMID
2183:PMID
2138:PMID
2103:PMID
2060:PMID
2025:PMID
1996:PMID
1953:PMID
1915:PMID
1877:PMID
1861:Cell
1848:PMID
1819:PMID
1790:PMID
1747:PMID
1712:PMID
1675:PMID
1637:PMID
1602:PMID
1559:PMID
1494:PMID
1445:PMID
1258:high
1171:and
1134:gene
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
126:OMIM
83:2VAY
64:RCSB
61:PDBe
4227:(+
4065:4AP
3978:HCN
3511:9.3
3506:9.2
3501:9.1
3492:8.2
3487:8.1
3478:7.5
3473:7.4
3468:7.3
3463:7.2
3458:7.1
3440:6.4
3435:6.3
3430:6.2
3425:6.1
3416:5.1
3407:4.3
3402:4.2
3397:4.1
3388:3.4
3383:3.3
3378:3.2
3373:3.1
3364:2.2
3359:2.1
3350:1.8
3345:1.7
3340:1.6
3335:1.5
3330:1.4
3325:1.3
3320:1.2
3315:1.1
3211:K2P
3191:7.1
3186:6.2
3181:6.1
3176:5.1
3171:4.2
3166:4.1
3151:3.4
3146:3.3
3141:3.2
3136:3.1
3117:2.6
3112:2.4
3107:2.3
3102:2.2
3097:2.1
3092:1.1
3078:ATP
3056:5.1
3051:4.2
3046:4.1
3041:3.1
3036:2.3
3031:2.2
3026:2.1
3021:1.1
3006:IK1
2996:SK3
2991:SK2
2986:SK1
2865:1.9
2860:1.8
2855:1.7
2850:1.6
2845:1.5
2840:1.4
2835:1.3
2830:1.2
2825:1.1
2714:Na:
2566:3.3
2561:3.2
2556:3.1
2510:2.1
2477:1.4
2472:1.3
2467:1.2
2462:1.1
2371:Ca:
2255:doi
2224:PMC
2216:doi
2173:PMC
2163:doi
2128:doi
2124:273
2093:PMC
2085:doi
2050:doi
2017:doi
1986:PMC
1978:doi
1945:doi
1907:doi
1869:doi
1840:doi
1811:doi
1780:PMC
1772:doi
1737:PMC
1704:doi
1667:doi
1655:328
1627:doi
1623:263
1592:doi
1588:267
1551:doi
1484:PMC
1476:doi
1472:115
1435:doi
1431:277
1283:by
1245:ion
1234:In
1121:, (
1115:1.1
821:779
356:End
255:End
158:OMA
134:MGI
54:PDB
4567::
4449:D
4429:C
4389:B
4349:A
4231:):
3984:FC
3878:1B
3873:1A
3861:L1
3819:KB
3814:KA
3693:Cl
3286:18
3281:17
3276:16
3271:15
3266:13
3261:12
3256:10
3160:ir
3130:ir
3086:ir
3015:Ca
2974:β4
2969:β3
2964:β2
2959:β1
2954:α1
2926:K:
2877:Na
2870:7A
2816:Na
2643:γ4
2638:γ3
2633:γ2
2628:γ1
2616:β4
2611:β3
2606:β2
2601:β1
2547:Ca
2534:Ca
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