342:
319:
241:
216:
3307:
2360:
2375:
600:
2345:
593:
348:
247:
29:
2315:
2390:
2330:
1176:
1159:
yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene
2223:
55:
1350:
ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 GRCh38: Ensembl release 89: ENSG00000243570, ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534,
1740:
Yancey KB, Overholser O, Domloge-Hultsch N, Li LJ, Caughman SW, Bisalbutra P (March 1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway".
355:
254:
1172:. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
2024:"Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment"
1889:
Wu LC, Morley BJ, Campbell RD (January 1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements".
2359:
2374:
1656:
Arnason A, Larsen B, Marshall WH, Edwards JH, Macintosh P, Olaisen B, Teisberg P (August 1977). "Very close linkage between HLA-B and Bf inferred from allelic association".
3257:
828:
3117:
177:
809:
1155:
activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement
2153:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2857:
1406:
1388:
2430:
1703:"Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG"
2344:
1073:
1066:
3348:
2877:
1427:
2102:"Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product"
1848:"Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement"
1285:
2294:
1371:
3367:
1239:
52:
2182:
Mejía JE, Jahn I, de la Salle H, Hauptmann G (January 1994). "Human factor B. Complete cDNA sequence of the BF*S allele".
1349:
2850:
2644:
341:
2835:
1161:
318:
148:, Cfb, AI195813, AI255840, Bf, C2, Fb, H2-Bf, AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, PBF2, complement factor B
2423:
1375:
1354:
2843:
2463:
1206:
1148:
899:
2314:
880:
876:
866:
862:
858:
854:
850:
3341:
3077:
2453:
1304:
1196:
240:
215:
157:
1981:"Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen"
1809:
Davrinche C, Abbal M, Clerc A (1991). "Molecular characterization of human complement factor B subtypes".
3372:
2416:
2389:
2368:: Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)
354:
253:
2992:
2977:
2699:
2287:
1217:
347:
246:
144:
3377:
2874:
2242:
1049:
1041:
990:
165:
2329:
3334:
3267:
3232:
3227:
2779:
2649:
2614:
2609:
2504:
2499:
2494:
2383:: Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid
1928:"Molecular cloning and characterization of the gene coding for human complement protein factor B"
1266:
1045:
1020:
994:
969:
2669:
2659:
2654:
2604:
2583:
2528:
2511:
2238:
1212:
1192:
3322:
3222:
3072:
2751:
2746:
2547:
1262:
3212:
2761:
2756:
2280:
2233:
2113:
1939:
1665:
1562:
1169:
229:
1524:
Campbell RD (January 1987). "The molecular genetics and polymorphism of C2 and factor B".
8:
3112:
2919:
2914:
2738:
2718:
2708:
1627:
Rawal N, Pangburn MK (March 2001). "Structure/function of C5 convertases of complement".
185:
2117:
1943:
1669:
1566:
1555:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
2048:
2023:
1996:
1914:
1872:
1847:
1834:
1792:
1771:
1723:
1702:
1689:
1615:
1537:
1507:
1482:
189:
2865:
2136:
2101:
2083:
2066:
2005:
1980:
1962:
1927:
1640:
743:
738:
733:
728:
723:
718:
702:
697:
692:
687:
682:
666:
661:
656:
651:
646:
641:
3094:
2439:
2258:
2249:
2199:
2195:
2170:
2166:
2141:
2088:
2053:
2010:
1967:
1906:
1902:
1877:
1826:
1797:
1758:
1728:
1681:
1644:
1607:
1578:
1541:
1512:
1469:
1184:
1152:
137:
45:
1918:
1838:
1619:
2886:
2813:
2766:
2588:
2191:
2162:
2131:
2121:
2078:
2043:
2035:
2000:
1992:
1957:
1947:
1898:
1867:
1859:
1818:
1787:
1779:
1750:
1718:
1710:
1693:
1673:
1636:
1599:
1570:
1533:
1502:
1494:
1459:
434:
365:
309:
264:
169:
1553:
Campbell RD, Bentley DR, Morley BJ (September 1984). "The factor B and C2 genes".
1448:"The Ba fragment of complement factor B inhibits human B lymphocyte proliferation"
3127:
3122:
2894:
2870:
2542:
2538:
1754:
409:
193:
3306:
1464:
1447:
1411:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1393:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3318:
2458:
2106:
Proceedings of the
National Academy of Sciences of the United States of America
1932:
Proceedings of the
National Academy of Sciences of the United States of America
510:
2218:
3361:
3272:
3145:
3134:
2866:
2628:
2623:
1590:
Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster".
1165:
628:
2126:
1952:
599:
570:
448:
3168:
3062:
2904:
2824:
2819:
2807:
2789:
2784:
2694:
2100:
Woods DE, Markham AF, Ricker AT, Goldberger G, Colten HR (September 1982).
1648:
1611:
1574:
1516:
1323:
1243:
427:
206:
2203:
2174:
2145:
2092:
2057:
2014:
1971:
1910:
1881:
1830:
1801:
1762:
1732:
1582:
1545:
1473:
1113:
1108:
592:
3287:
3282:
2931:
2067:"Complete primary structure for the zymogen of human complement factor B"
1685:
944:
925:
1498:
3249:
3191:
2972:
2967:
2947:
2664:
2489:
1822:
326:
223:
173:
28:
2039:
1863:
1783:
1714:
1603:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
3314:
3277:
3263:
3082:
2962:
2952:
2567:
1677:
1483:"Complement in age-related macular degeneration: a focus on function"
1175:
773:
393:
380:
292:
279:
181:
2408:
3163:
3158:
3107:
2957:
2942:
2909:
2728:
2562:
2219:
GeneReviews/NCBI/NIH/UW entry on
Atypical Hemolytic-Uremic Syndrome
1156:
1097:
3217:
3207:
3153:
3067:
2899:
2263:
2253:
1739:
1129:
911:
840:
758:
754:
161:
3244:
3186:
2229:
1081:
795:
2272:
1772:"The principal site of glycation of human complement factor B"
608:
3253:
3239:
3178:
3052:
3047:
3042:
3037:
3032:
3027:
2770:
2181:
2248:
Overview of all the structural information available in the
2099:
1701:
Barnum SR, Ishii Y, Agrawal A, Volanakis JE (October 1992).
1655:
3022:
3017:
3012:
3007:
3002:
2997:
2987:
2982:
2774:
2703:
2597:
1700:
1136:
2353:: Crystal Structure Analysis of the Bb segment of Factor B
1147:
This gene encodes complement factor B, a component of the
2593:
2521:
2516:
2065:
Mole JE, Anderson JK, Davison EA, Woods DE (March 1984).
2064:
417:
1845:
1446:
Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990).
1445:
2232:
online database for peptidases and their inhibitors:
1552:
582:
1846:
Farries TC, Lachmann PJ, Harrison RA (August 1988).
1808:
1480:
2224:OMIM entries on Atypical Hemolytic-Uremic Syndrome
1769:
1367:
1365:
1363:
1345:
1343:
1341:
1179:Alternative pathway. (Some labels are in Polish.)
364:
263:
3359:
1888:
1360:
1338:
16:Protein-coding gene in the species Homo sapiens
2152:
2021:
1978:
1925:
1770:Niemann MA, Bhown AS, Miller EJ (March 1991).
1481:Bradley DT, Zipfel PF, Hughes AE (June 2011).
1372:GRCm38: Ensembl release 89: ENSMUSG00000090231
3342:
2851:
2424:
2288:
1626:
3349:
3335:
2858:
2844:
2431:
2417:
2295:
2281:
739:complement activation, alternative pathway
2241:at the U.S. National Library of Medicine
2135:
2125:
2082:
2047:
2004:
1961:
1951:
1871:
1791:
1722:
1506:
1463:
1743:The Journal of Investigative Dermatology
1592:Experimental and Clinical Immunogenetics
1523:
1422:
1420:
1174:
1979:Morley BJ, Campbell RD (January 1984).
3360:
2871:serine proteases/serine endopeptidases
2022:Christie DL, Gagnon J (January 1983).
1428:"Entrez Gene: CFB complement factor B"
2839:
2438:
2412:
2276:
1417:
369:
330:
325:
268:
227:
222:
3301:
1926:Campbell RD, Porter RR (July 1983).
2071:The Journal of Biological Chemistry
724:regulation of complement activation
13:
1997:10.1002/j.1460-2075.1984.tb01776.x
1589:
1538:10.1093/oxfordjournals.bmb.a072175
1438:
652:serine-type endopeptidase activity
14:
3389:
2323:: FACTOR B SERINE PROTEASE DOMAIN
2212:
1709:. 287. 287 ( Pt 2) (2): 595–601.
1132:that in humans is encoded by the
3305:
2388:
2373:
2358:
2343:
2328:
2313:
1778:. 274. 274 ( Pt 2) (2): 473–80.
1629:International Immunopharmacology
1162:major histocompatibility complex
598:
591:
353:
346:
340:
317:
252:
245:
239:
214:
27:
2302:
1399:
1381:
647:serine-type peptidase activity
609:More reference expression data
571:More reference expression data
479:olfactory zone of nasal mucosa
1:
3083:Urinary plasminogen activator
2262:(Complement factor B) at the
2084:10.1016/S0021-9258(17)43108-5
1641:10.1016/S1567-5769(00)00039-4
1331:
338:
237:
3321:. You can help Knowledge by
3078:Tissue plasminogen activator
2196:10.1016/0198-8859(94)90100-7
2167:10.1016/0378-1119(94)90802-8
1903:10.1016/0092-8674(87)90436-3
1755:10.1111/1523-1747.ep12499812
7:
3368:Genes on human chromosome 6
2398:: Human Complement factor B
1465:10.4049/jimmunol.144.5.1549
1142:
10:
3394:
3300:
3200:
3177:
3169:Proteinase 3/Myeloblastin
3143:
3093:
2930:
2885:
2800:
2737:
2700:Decay-accelerating factor
2684:
2637:
2576:
2479:
2472:
2446:
2308:
1407:"Mouse PubMed Reference:"
1389:"Human PubMed Reference:"
1112:
1107:
1103:
1096:
1080:
1061:
1038:
1034:
1017:
1013:
1006:
987:
983:
966:
962:
955:
942:
938:
923:
919:
910:
897:
893:
874:
848:
839:
826:
822:
807:
803:
794:
779:
772:
768:
752:
627:
623:
606:
590:
581:
568:
517:
508:
483:Descending thoracic aorta
455:
446:
416:
408:
404:
387:
374:
337:
316:
307:
303:
286:
273:
236:
213:
204:
200:
155:
152:
142:
135:
130:
71:
66:
49:
44:
39:
35:
26:
21:
2243:Medical Subject Headings
1526:British Medical Bulletin
1074:Chr 17: 35.08 – 35.08 Mb
2127:10.1073/pnas.79.18.5661
2028:The Biochemical Journal
1953:10.1073/pnas.80.14.4464
1852:The Biochemical Journal
1776:The Biochemical Journal
1707:The Biochemical Journal
1067:Chr 6: 31.95 – 31.95 Mb
3223:Proprotein convertases
2338:: A domain of Factor B
1575:10.1098/rstb.1984.0097
1180:
744:innate immune response
371:17 B1|17 18.41 cM
3073:Plasminogen activator
1452:Journal of Immunology
1178:
734:immune system process
719:complement activation
698:extracellular exosome
491:right coronary artery
332:Chromosome 17 (mouse)
3213:Prolyl endopeptidase
2739:Complement receptors
683:extracellular region
537:hepatobiliary system
533:white adipose tissue
230:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
2239:Complement+Factor+B
2118:1982PNAS...79.5661W
1944:1983PNAS...80.4464C
1670:1977Natur.268..527A
1567:1984RSPTB.306..367C
1499:10.1038/eye.2011.37
1188:
1149:alternative pathway
1126:Complement factor B
703:extracellular space
693:blood microparticle
475:islet of Langerhans
459:right lobe of liver
2568:Factor P/Properdin
2473:Activators/enzymes
1823:10.1007/bf00211644
1183:
1181:
900:ENSMUSG00000090231
712:Biological process
676:Cellular component
662:complement binding
657:hydrolase activity
642:peptidase activity
635:Molecular function
3373:Complement system
3330:
3329:
3298:
3297:
3095:Complement system
2887:Digestive enzymes
2833:
2832:
2680:
2679:
2440:Complement system
2406:
2405:
2040:10.1042/bj2090061
1864:10.1042/bj2530667
1784:10.1042/bj2740473
1715:10.1042/bj2870595
1604:10.1159/000019075
1329:
1328:
1160:localizes to the
1123:
1122:
1119:
1118:
1092:
1091:
1057:
1056:
1028:
1027:
1002:
1001:
977:
976:
951:
950:
932:
931:
906:
905:
887:
886:
835:
834:
816:
815:
764:
763:
619:
618:
615:
614:
577:
576:
564:
563:
502:
501:
400:
399:
299:
298:
126:
125:
122:
121:
50:Ortholog search:
3385:
3351:
3344:
3337:
3309:
3302:
2860:
2853:
2846:
2837:
2836:
2814:immune adherence
2477:
2476:
2433:
2426:
2419:
2410:
2409:
2392:
2377:
2362:
2347:
2332:
2317:
2297:
2290:
2283:
2274:
2273:
2207:
2184:Human Immunology
2178:
2149:
2139:
2129:
2096:
2086:
2061:
2051:
2018:
2008:
1985:The EMBO Journal
1975:
1965:
1955:
1922:
1885:
1875:
1842:
1805:
1795:
1766:
1736:
1726:
1697:
1678:10.1038/268527a0
1652:
1623:
1586:
1561:(1129): 367–78.
1549:
1520:
1510:
1477:
1467:
1432:
1431:
1424:
1415:
1414:
1403:
1397:
1396:
1385:
1379:
1369:
1358:
1347:
1189:
1182:
1105:
1104:
1076:
1069:
1052:
1032:
1031:
1023:
1011:
1010:
1007:RefSeq (protein)
997:
981:
980:
972:
960:
959:
936:
935:
917:
916:
891:
890:
870:
846:
845:
820:
819:
801:
800:
770:
769:
625:
624:
611:
602:
595:
588:
587:
573:
513:
511:Top expressed in
506:
505:
451:
449:Top expressed in
444:
443:
423:
422:
406:
405:
396:
383:
372:
357:
350:
344:
333:
321:
305:
304:
295:
282:
271:
256:
249:
243:
232:
218:
202:
201:
196:
147:
140:
117:
64:
63:
58:
37:
36:
31:
19:
18:
3393:
3392:
3388:
3387:
3386:
3384:
3383:
3382:
3378:Hydrolase stubs
3358:
3357:
3356:
3355:
3299:
3294:
3196:
3173:
3139:
3089:
2926:
2895:Enteropeptidase
2881:
2864:
2834:
2829:
2796:
2733:
2676:
2633:
2572:
2468:
2442:
2437:
2407:
2402:
2399:
2393:
2384:
2378:
2369:
2363:
2354:
2348:
2339:
2333:
2324:
2318:
2304:
2301:
2270:
2215:
2210:
1664:(5620): 527–8.
1441:
1439:Further reading
1436:
1435:
1426:
1425:
1418:
1405:
1404:
1400:
1387:
1386:
1382:
1370:
1361:
1351:ENSG00000204359
1348:
1339:
1334:
1145:
1114:View/Edit Mouse
1109:View/Edit Human
1072:
1065:
1062:Location (UCSC)
1048:
1044:
1040:
1019:
993:
989:
968:
881:ENSG00000204359
879:
877:ENSG00000241534
869:
867:ENSG00000242335
865:
863:ENSG00000241253
861:
859:ENSG00000243649
857:
855:ENSG00000239754
853:
851:ENSG00000243570
849:
748:
707:
688:plasma membrane
671:
667:protein binding
607:
597:
596:
569:
560:
555:
551:
547:
543:
539:
535:
531:
527:
523:
521:proximal tubule
509:
498:
493:
489:
485:
481:
477:
473:
469:
465:
461:
447:
391:
378:
370:
360:
359:
358:
351:
331:
308:Gene location (
290:
277:
269:
259:
258:
257:
250:
228:
205:Gene location (
194:CFB - orthologs
156:
143:
136:
73:
51:
17:
12:
11:
5:
3391:
3381:
3380:
3375:
3370:
3354:
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3346:
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3328:
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3310:
3296:
3295:
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3215:
3210:
3204:
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3175:
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3141:
3140:
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3132:
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3125:
3115:
3110:
3105:
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3015:
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2907:
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2897:
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2889:
2883:
2882:
2867:Endopeptidases
2863:
2862:
2855:
2848:
2840:
2831:
2830:
2828:
2827:
2822:
2816:
2811:
2804:
2802:
2798:
2797:
2795:
2794:
2793:
2792:
2787:
2777:
2764:
2759:
2754:
2749:
2743:
2741:
2735:
2734:
2732:
2731:
2722:
2721:
2712:
2711:
2706:
2697:
2688:
2686:
2682:
2681:
2678:
2677:
2675:
2674:
2673:
2672:
2667:
2662:
2657:
2652:
2641:
2639:
2635:
2634:
2632:
2631:
2626:
2620:
2619:
2618:
2617:
2612:
2602:
2601:
2600:
2591:
2580:
2578:
2574:
2573:
2571:
2570:
2565:
2560:
2551:
2550:
2545:
2532:
2531:
2526:
2525:
2524:
2519:
2509:
2508:
2507:
2502:
2497:
2483:
2481:
2474:
2470:
2469:
2467:
2466:
2461:
2456:
2450:
2448:
2444:
2443:
2436:
2435:
2428:
2421:
2413:
2404:
2403:
2401:
2400:
2394:
2387:
2385:
2379:
2372:
2370:
2364:
2357:
2355:
2349:
2342:
2340:
2334:
2327:
2325:
2319:
2312:
2309:
2306:
2305:
2300:
2299:
2292:
2285:
2277:
2268:
2267:
2246:
2236:
2226:
2221:
2214:
2213:External links
2211:
2209:
2208:
2179:
2161:(1–2): 171–4.
2150:
2112:(18): 5661–5.
2097:
2077:(6): 3407–12.
2062:
2019:
1976:
1938:(14): 4464–8.
1923:
1886:
1843:
1811:Immunogenetics
1806:
1767:
1737:
1698:
1653:
1624:
1587:
1550:
1521:
1478:
1458:(5): 1549–53.
1442:
1440:
1437:
1434:
1433:
1416:
1398:
1380:
1359:
1336:
1335:
1333:
1330:
1327:
1326:
1321:
1318:
1315:
1312:
1308:
1307:
1302:
1299:
1296:
1293:
1289:
1288:
1283:
1280:
1277:
1274:
1270:
1269:
1260:
1257:
1254:
1251:
1247:
1246:
1237:
1234:
1231:
1228:
1224:
1223:
1220:
1215:
1210:
1200:
1144:
1141:
1121:
1120:
1117:
1116:
1111:
1101:
1100:
1094:
1093:
1090:
1089:
1087:
1085:
1078:
1077:
1070:
1063:
1059:
1058:
1055:
1054:
1036:
1035:
1029:
1026:
1025:
1015:
1014:
1008:
1004:
1003:
1000:
999:
985:
984:
978:
975:
974:
964:
963:
957:
953:
952:
949:
948:
940:
939:
933:
930:
929:
921:
920:
914:
908:
907:
904:
903:
895:
894:
888:
885:
884:
872:
871:
843:
837:
836:
833:
832:
824:
823:
817:
814:
813:
805:
804:
798:
792:
791:
786:
781:
777:
776:
766:
765:
762:
761:
750:
749:
747:
746:
741:
736:
731:
726:
721:
715:
713:
709:
708:
706:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
654:
649:
644:
638:
636:
632:
631:
621:
620:
617:
616:
613:
612:
604:
603:
585:
579:
578:
575:
574:
566:
565:
562:
561:
559:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
515:
514:
503:
500:
499:
497:
496:
492:
488:
487:gastric mucosa
484:
480:
476:
472:
468:
464:
460:
456:
453:
452:
440:
439:
431:
420:
414:
413:
410:RNA expression
402:
401:
398:
397:
389:
385:
384:
376:
373:
368:
362:
361:
352:
345:
339:
335:
334:
329:
323:
322:
314:
313:
301:
300:
297:
296:
288:
284:
283:
275:
272:
267:
261:
260:
251:
244:
238:
234:
233:
226:
220:
219:
211:
210:
198:
197:
154:
150:
149:
141:
133:
132:
128:
127:
124:
123:
120:
119:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
3390:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3363:
3352:
3347:
3345:
3340:
3338:
3333:
3332:
3326:
3324:
3320:
3317:article is a
3316:
3311:
3308:
3304:
3303:
3289:
3286:
3284:
3281:
3280:
3279:
3276:
3274:
3273:Streptokinase
3271:
3269:
3265:
3262:
3259:
3255:
3251:
3248:
3246:
3243:
3241:
3238:
3234:
3231:
3229:
3226:
3225:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3205:
3203:
3199:
3193:
3190:
3188:
3185:
3184:
3182:
3180:
3176:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3151:
3149:
3147:
3146:immune system
3142:
3136:
3135:C3-convertase
3133:
3129:
3126:
3124:
3121:
3120:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3100:
3098:
3096:
3092:
3084:
3081:
3079:
3076:
3075:
3074:
3071:
3069:
3066:
3064:
3060:
3059:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2975:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2938:
2937:
2935:
2933:
2929:
2921:
2918:
2916:
2913:
2912:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2892:
2890:
2888:
2884:
2879:
2876:
2872:
2868:
2861:
2856:
2854:
2849:
2847:
2842:
2841:
2838:
2826:
2823:
2821:
2817:
2815:
2812:
2809:
2806:
2805:
2803:
2799:
2791:
2788:
2786:
2783:
2782:
2781:
2780:Anaphylatoxin
2778:
2776:
2772:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2744:
2742:
2740:
2736:
2730:
2727:
2724:
2723:
2720:
2717:
2714:
2713:
2710:
2707:
2705:
2701:
2698:
2696:
2693:
2690:
2689:
2687:
2683:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2651:
2648:
2647:
2646:
2643:
2642:
2640:
2636:
2630:
2629:C5-convertase
2627:
2625:
2624:C3-convertase
2622:
2621:
2616:
2613:
2611:
2608:
2607:
2606:
2603:
2599:
2595:
2592:
2590:
2587:
2586:
2585:
2582:
2581:
2579:
2575:
2569:
2566:
2564:
2561:
2559:
2556:
2553:
2552:
2549:
2546:
2544:
2540:
2537:
2534:
2533:
2530:
2527:
2523:
2520:
2518:
2515:
2514:
2513:
2510:
2506:
2503:
2501:
2498:
2496:
2493:
2492:
2491:
2488:
2485:
2484:
2482:
2478:
2475:
2471:
2465:
2462:
2460:
2457:
2455:
2452:
2451:
2449:
2445:
2441:
2434:
2429:
2427:
2422:
2420:
2415:
2414:
2411:
2397:
2391:
2386:
2382:
2376:
2371:
2367:
2361:
2356:
2352:
2346:
2341:
2337:
2331:
2326:
2322:
2316:
2311:
2310:
2307:
2298:
2293:
2291:
2286:
2284:
2279:
2278:
2275:
2271:
2265:
2261:
2260:
2255:
2251:
2247:
2244:
2240:
2237:
2235:
2231:
2227:
2225:
2222:
2220:
2217:
2216:
2205:
2201:
2197:
2193:
2189:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2151:
2147:
2143:
2138:
2133:
2128:
2123:
2119:
2115:
2111:
2107:
2103:
2098:
2094:
2090:
2085:
2080:
2076:
2072:
2068:
2063:
2059:
2055:
2050:
2045:
2041:
2037:
2033:
2029:
2025:
2020:
2016:
2012:
2007:
2002:
1998:
1994:
1990:
1986:
1982:
1977:
1973:
1969:
1964:
1959:
1954:
1949:
1945:
1941:
1937:
1933:
1929:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1897:(2): 331–42.
1896:
1892:
1887:
1883:
1879:
1874:
1869:
1865:
1861:
1858:(3): 667–75.
1857:
1853:
1849:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1817:(5): 309–12.
1816:
1812:
1807:
1803:
1799:
1794:
1789:
1785:
1781:
1777:
1773:
1768:
1764:
1760:
1756:
1752:
1749:(3): 379–83.
1748:
1744:
1738:
1734:
1730:
1725:
1720:
1716:
1712:
1708:
1704:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1654:
1650:
1646:
1642:
1638:
1635:(3): 415–22.
1634:
1630:
1625:
1621:
1617:
1613:
1609:
1605:
1601:
1598:(4): 213–30.
1597:
1593:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1551:
1547:
1543:
1539:
1535:
1531:
1527:
1522:
1518:
1514:
1509:
1504:
1500:
1496:
1493:(6): 683–93.
1492:
1488:
1484:
1479:
1475:
1471:
1466:
1461:
1457:
1453:
1449:
1444:
1443:
1429:
1423:
1421:
1412:
1408:
1402:
1394:
1390:
1384:
1377:
1373:
1368:
1366:
1364:
1356:
1352:
1346:
1344:
1342:
1337:
1325:
1322:
1319:
1316:
1313:
1310:
1309:
1306:
1303:
1300:
1297:
1294:
1291:
1290:
1287:
1284:
1281:
1278:
1275:
1272:
1271:
1268:
1264:
1261:
1258:
1255:
1252:
1249:
1248:
1245:
1241:
1238:
1235:
1232:
1229:
1226:
1225:
1221:
1219:
1216:
1214:
1211:
1208:
1204:
1201:
1198:
1194:
1191:
1190:
1186:
1177:
1173:
1171:
1167:
1166:MHC class III
1163:
1158:
1154:
1150:
1140:
1138:
1135:
1131:
1127:
1115:
1110:
1106:
1102:
1099:
1095:
1088:
1086:
1083:
1079:
1075:
1071:
1068:
1064:
1060:
1053:
1051:
1047:
1043:
1037:
1033:
1030:
1024:
1022:
1016:
1012:
1009:
1005:
998:
996:
992:
986:
982:
979:
973:
971:
965:
961:
958:
956:RefSeq (mRNA)
954:
947:
946:
941:
937:
934:
928:
927:
922:
918:
915:
913:
909:
902:
901:
896:
892:
889:
883:
882:
878:
873:
868:
864:
860:
856:
852:
847:
844:
842:
838:
831:
830:
825:
821:
818:
812:
811:
806:
802:
799:
797:
793:
790:
787:
785:
782:
778:
775:
771:
767:
760:
756:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
716:
714:
711:
710:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
630:
629:Gene ontology
626:
622:
610:
605:
601:
594:
589:
586:
584:
580:
572:
567:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
519:
516:
512:
507:
504:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
457:
454:
450:
445:
442:
441:
438:
436:
432:
430:
429:
425:
424:
421:
419:
415:
411:
407:
403:
395:
390:
386:
382:
377:
367:
363:
356:
349:
343:
336:
328:
324:
320:
315:
311:
306:
302:
294:
289:
285:
281:
276:
266:
262:
255:
248:
242:
235:
231:
225:
221:
217:
212:
208:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
151:
146:
139:
134:
129:
118:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3323:expanding it
3312:
3102:
3063:fibrinolysis
3061:
2939:
2905:Chymotrypsin
2825:Opsonization
2820:inflammation
2808:Cytotoxicity
2725:
2715:
2695:C1-inhibitor
2691:
2557:
2554:
2535:
2486:
2395:
2380:
2365:
2350:
2335:
2320:
2269:
2257:
2190:(1): 49–53.
2187:
2183:
2158:
2154:
2109:
2105:
2074:
2070:
2034:(1): 61–70.
2031:
2027:
1991:(1): 153–7.
1988:
1984:
1935:
1931:
1894:
1890:
1855:
1851:
1814:
1810:
1775:
1746:
1742:
1706:
1661:
1657:
1632:
1628:
1595:
1591:
1558:
1554:
1532:(1): 37–49.
1529:
1525:
1490:
1486:
1455:
1451:
1410:
1401:
1392:
1383:
1324:inflammation
1202:
1170:chromosome 6
1168:) region on
1146:
1133:
1125:
1124:
1050:NP_001389804
1042:NP_001136178
1039:
1018:
991:NM_001142706
988:
967:
943:
924:
898:
875:
827:
808:
788:
783:
529:human kidney
525:right kidney
495:human kidney
433:
426:
153:External IDs
72:
2968:Factor XIIa
2948:Factor VIIa
2932:Coagulation
2303:PDB gallery
1222:Conditions
729:proteolysis
463:gallbladder
392:35,081,494
379:35,075,350
291:31,952,084
278:31,945,650
131:Identifiers
3362:Categories
3250:Subtilisin
3192:Batroxobin
2973:Kallikrein
2963:Factor XIa
2953:Factor IXa
2920:Pancreatic
2915:Neutrophil
2685:Inhibitors
1378:, May 2017
1357:, May 2017
1332:References
1185:Complement
1153:complement
437:(ortholog)
174:HomoloGene
3315:hydrolase
3278:Cathepsin
3264:Sedolisin
3240:Prostasin
2958:Factor Xa
2818:Inducing
1242:, C3 NeF
1046:NP_032224
1021:NP_001701
995:NM_008198
970:NM_001710
774:Orthologs
182:GeneCards
3179:Venombin
3164:Tryptase
3159:Granzyme
3113:Factor I
3108:Factor D
3103:Factor B
2943:Thrombin
2940:factors:
2910:Elastase
2810:(by MAC)
2801:Function
2729:Factor H
2709:Factor I
2563:Factor D
2558:Factor B
2447:Pathways
1919:32752642
1839:13698345
1649:11367526
1620:25061446
1612:10072631
1517:21394116
1374:–
1353:–
1157:factor D
1143:Function
1098:Wikidata
753:Sources:
557:duodenum
471:duodenum
467:appendix
3218:Pronase
3208:Acrosin
3154:Chymase
3068:Plasmin
2900:Trypsin
2264:PDBe-KB
2254:UniProt
2234:S01.196
2204:8181962
2175:8125298
2146:6957884
2114:Bibcode
2093:6546754
2058:6342610
2049:1154056
2015:6323161
1972:6308626
1940:Bibcode
1911:3643061
1882:3140783
1873:1149358
1831:2249879
1802:2006911
1793:1150163
1763:1545147
1733:1445220
1724:1133207
1694:4262433
1666:Bibcode
1583:6149579
1563:Bibcode
1546:3315100
1508:3178140
1474:2307833
1376:Ensembl
1355:Ensembl
1130:protein
912:UniProt
841:Ensembl
780:Species
759:QuickGO
545:jejunum
412:pattern
270:6p21.33
138:Aliases
3245:Reelin
3187:Ancrod
3144:Other
2878:3.4.21
2577:Middle
2259:P00751
2245:(MeSH)
2230:MEROPS
2202:
2173:
2144:
2137:346964
2134:
2091:
2056:
2046:
2013:
2006:557312
2003:
1970:
1963:384059
1960:
1917:
1909:
1880:
1870:
1837:
1829:
1800:
1790:
1761:
1731:
1721:
1692:
1686:889587
1684:
1658:Nature
1647:
1618:
1610:
1581:
1544:
1515:
1505:
1472:
1187:tests
1084:search
1082:PubMed
945:P04186
926:P00751
796:Entrez
583:BioGPS
170:105975
162:138470
3313:This
3254:Furin
3201:Other
3128:MASP2
3123:MASP1
3053:KLK15
3048:KLK14
3043:KLK13
3038:KLK12
3033:KLK11
3028:KLK10
2771:CD11c
2767:CD11b
2543:MASP2
2539:MASP1
2480:Early
1915:S2CID
1835:S2CID
1690:S2CID
1616:S2CID
1128:is a
829:14962
789:Mouse
784:Human
755:Amigo
553:colon
549:ileum
541:liver
435:Mouse
428:Human
375:Start
310:Mouse
274:Start
207:Human
3319:stub
3268:TPP1
3118:MASP
3023:KLK9
3018:KLK8
3013:KLK7
3008:KLK6
3003:KLK5
2998:KLK4
2993:KLK3
2988:KLK2
2983:KLK1
2775:CD18
2719:C4BP
2704:CD59
2692:CLA:
2638:Late
2598:iC3b
2396:2ok5
2381:1rtk
2366:1rs0
2351:1rrk
2336:1q0p
2321:1dle
2252:for
2228:The
2200:PMID
2171:PMID
2155:Gene
2142:PMID
2089:PMID
2054:PMID
2011:PMID
1968:PMID
1907:PMID
1891:Cell
1878:PMID
1827:PMID
1798:PMID
1759:PMID
1729:PMID
1682:PMID
1645:PMID
1608:PMID
1579:PMID
1542:PMID
1513:PMID
1470:PMID
1295:·/↓
1286:TCPD
1218:CH50
1137:gene
418:Bgee
366:Band
327:Chr.
265:Band
224:Chr.
178:1292
158:OMIM
115:3HRZ
111:2XWJ
107:2XWB
103:2WIN
99:2OK5
95:1RTK
91:1RS0
87:1RRK
83:1Q0P
79:1DLE
75:3HS0
56:RCSB
53:PDBe
3258:S1P
2978:PSA
2790:C5a
2785:C3a
2762:CR4
2757:CR3
2752:CR2
2747:CR1
2716:CL:
2650:C5b
2645:MAC
2615:C5b
2610:C5a
2594:C3b
2589:C3a
2548:MBL
2522:C4b
2517:C4a
2505:C1s
2500:C1r
2495:C1q
2250:PDB
2192:doi
2163:doi
2159:138
2132:PMC
2122:doi
2079:doi
2075:259
2044:PMC
2036:doi
2032:209
2001:PMC
1993:doi
1958:PMC
1948:doi
1899:doi
1868:PMC
1860:doi
1856:253
1819:doi
1788:PMC
1780:doi
1751:doi
1719:PMC
1711:doi
1674:doi
1662:268
1637:doi
1600:doi
1571:doi
1559:306
1534:doi
1503:PMC
1495:doi
1487:Eye
1460:doi
1456:144
1305:SLE
1267:C4D
1263:HAE
1240:PSG
1151:of
1134:CFB
810:629
388:End
287:End
190:OMA
186:CFB
166:MGI
145:CFB
46:PDB
22:CFB
3364::
2875:EC
2869::
2726:A:
2670:C9
2665:C8
2660:C7
2655:C6
2605:C5
2584:C3
2555:A:
2536:L:
2529:C2
2512:C4
2490:C1
2487:C:
2256::
2198:.
2188:39
2186:.
2169:.
2157:.
2140:.
2130:.
2120:.
2110:79
2108:.
2104:.
2087:.
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1987:.
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1936:80
1934:.
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1409:.
1391:.
1362:^
1340:^
1320:↑
1317:↑
1314:↑
1311:↑
1301:↓
1298:↓
1292:↓
1282:↓
1279:·
1276:·
1273:·
1265:,
1259:·
1256:↓
1253:·
1250:↓
1244:AA
1236:↓
1233:↓
1230:↓
1227:·
1213:C3
1209:)
1203:FB
1199:)
1193:C4
1139:.
757:/
394:bp
381:bp
293:bp
280:bp
188:;
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180:;
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113:,
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101:,
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3233:2
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2852:t
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2773:/
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2702:/
2596:/
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1989:3
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