771:
806:
547:
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76:
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980:) will travel through the systemic circulation, reach the right side of the heart, and travel through the pulmonary artery, resulting in a pulmonary embolism. Arterial thrombosis resulting from hypertension or atherosclerosis can become mobile and the resulting emboli can occlude any artery or arteriole downstream of the thrombus formation. This means that cerebral stroke, myocardial infarction, or any other organ can be affected.
449:, tiny thrombi (microthrombi) known as microclots can obstruct the flow of blood in the capillaries. Microclots are small clumps of blood that form within the circulation, usually as a result of a larger thrombus breaking down into smaller pieces. They can be a cause for concern as they can lead to blockages in small vessels and restrict blood flow, leading to tissue damage and potentially causing
987:
break up the thrombus and blood flow is restored to the vessel. This may be aided by fibrinolytic drugs such as Tissue
Plasminogen Activator (tPA) in instances of coronary artery occlusion. The best response to fibrinolytic drugs is within a couple of hours, before the fibrin meshwork of the thrombus
704:
A thrombus occurs when the hemostatic process, which normally occurs in response to injury, becomes activated in an uninjured or slightly injured vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel (termed a mural thrombus). In a small blood vessel, blood flow may
699:
Animation of the formation of an occlusive thrombus in a vein. A few platelets attach themselves to the valve lips, constricting the opening and causing more platelets and red blood cells to aggregate and coagulate. Coagulation of unmoving blood on both sides of the blockage may propagate a clot in
866:
are used to inhibit the formation and growth of existing thrombi, with the former used for acute anticoagulation while the latter is used for long-term anticoagulation. The mechanism of action of heparin and warfarin are different as they work on different pathways of the
1007:-rich thrombus. If recanalization proceeds it provides capillary-sized channels through the thrombus for continuity of blood flow through the entire thrombus but may not restore sufficient blood flow for the metabolic needs of the downstream tissue.
709:. If an embolus becomes trapped within a blood vessel, it blocks blood flow and is termed as an embolism. Embolisms, depending on their specific location, can cause more significant effects like strokes, heart attacks, or even death.
529:
it is often a result of a heart attack complication. The thrombus in this case can separate from the chamber, be carried through arteries and block a blood vessel. They appear grey-red with alternating light and dark lines (known as
558:. The three factors have been further refined to include circulatory stasis, vascular wall injury, and hypercoagulable state, all of which contribute to increased risk for venous thromboembolism and other cardiovascular diseases.
1822:
1807:
805:
770:
966:
Propagation of a thrombus occurs towards the direction of the heart and involves the accumulation of additional platelets and fibrin. This means that it is anterograde in veins or retrograde in arteries.
918:(tPA) is a different enzyme that promotes the degradation of fibrin in clots but not free fibrinogen. This drug is made by transgenic bacteria and converts plasminogen into the clot-dissolving enzyme,
882:, an enzyme needed to synthesize vitamin K dependent clotting factors II, VII, IX, and X. Bleeding time with heparin and warfarin therapy can be measured with the partial thromboplastin time (PTT) and
760:, which is a protein encoded by the F3 gene. The platelet activation can potentially cause a cascade, eventually leading to the formation of the thrombus. This process is regulated through
655:(DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and subsequent activation of
705:
be completely cut off (termed an occlusive thrombus), resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is considered an
603:
changes (stasis, turbulence): Blood stasis promotes greater contact between platelets/coagulative factors with vascular endothelium. If rapid blood circulation (e.g., because of
554:
It was suggested over 150 years ago that thrombus formation is a result of abnormalities in blood flow, vessel wall, and blood components. This concept is now known as
926:
and enter interstitial fluid, where it then increases excitotoxicity, potentially affecting permeability of the blood–brain barrier, and causing cerebral hemorrhage.
1865:
972:
occurs when the thrombus breaks free from the vascular wall and becomes mobile, thereby traveling to other sites in the vasculature. A venous embolus (mostly from
419:
Thrombi are classified into two major groups depending on their location and the relative amount of platelets and red blood cells. The two major groups are:
356:, tiny thrombi known as microclots can obstruct the flow of blood in the capillaries. This can cause a number of problems particularly affecting the
793:
1783:
607:) occurs within vessels that have endothelial injuries, that creates disordered flow (turbulence) that can lead to the formation of thrombosis;
407:. They can restrict blood flow but usually do not block it entirely. They appear grey-red along with alternating light and dark lines (known as
1053:"Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin"
1858:
1673:
Medcalf, R. (2011). "Plasminogen activation-based thrombolysis for ischaemic stroke: the diversity of targets may demand new approaches".
922:. Recent research indicates that tPA could have toxic effects in the central nervous system. In cases of severe stroke, tPA can cross the
1851:
518:. They can restrict blood flow but usually do not block it entirely. Mural thrombi are usually found in vessels already damaged by
1198:
1774:
1982:
962:
Thrombus formation can have one of four outcomes: propagation, embolization, dissolution, and organization and recanalization.
652:
687:
to restore the level of clotting factors in the blood, as well as platelets and heparin to prevent further thrombi formation.
1752:
1608:
2157:
2140:
1251:"Anatomical and Pathological Observation and Analysis of SARS and COVID-19: Microthrombosis Is the Main Cause of Death"
1144:
Karaolanis G, Moris D, Bakoyiannis C, Tsilimigras DI, Palla VV, Spartalis E, Schizas D, Georgopoulos S (August 2017).
1575:
1320:
468:, resulting from reduced oxygen supply. Microclots have been found to be a characteristic feature in severe cases of
2219:
2171:
368:
resulting from reduced oxygen supply. Microclots have been found to be a characteristic feature in severe cases of
1626:"TPA modulation of the blood–brain barrier: A unifying explanation for the pleiotropic effects of tPA in the CNS?"
1938:
216:
2225:
2211:
610:
Common causes of stasis include anything that leads to prolonged immobility and reduced blood flow such as:
2199:
2162:
2032:
1023:
915:
161:
2352:
1928:
879:
411:) which represent bands of white blood cells and red blood cells (darker) entrapped in layers of fibrin.
878:, an enzyme that acts by inactivating thrombin and factor Xa. In contrast, warfarin works by inhibiting
2307:
2152:
2423:
1994:
1975:
1146:"A critical reappraisal of the treatment modalities of normal appearing thoracic aorta mural thrombi"
584:
485:
663:
and clotting factors. The result is hemorrhaging and ischemic necrosis of tissue/organs. Causes are
2393:
2136:
1965:
165:
1051:
Pretorius E, Vlok M, Venter C, Bezuidenhout JA, Laubscher GJ, Steenkamp J, Kell DB (August 2021).
2383:
2176:
923:
534:) which represent bands of white blood cells and red blood cells (darker) entrapped in layers of
129:
2297:
2272:
2230:
914:. However, streptokinase causes systemic fibrinolytic state and can lead to bleeding problems.
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Composition of a fresh thrombus at microscopy, showing nuclear debris in a background of
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Singh, Davinder P.; Basit, Hajira; Malik, Ahmad; Mahajan, Kunal (5 November 2021).
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442:
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349:
96:
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There are also some anticoagulants that come from animals that work by dissolving
740:), and genetic or disease-related deficiencies in the blood's clotting abilities.
2408:
2242:
2083:
1948:
1778:
1422:
1017:
720:
Some of the conditions which increase the risk of blood clots developing include
643:
576:(interior surface of blood vessel), causing platelet activation and aggregation;
519:
515:
404:
188:
1112:
2433:
2145:
2088:
1970:
1708:
Budzynski, A. Z. (1991). "Interaction of hementin with fibrinogen and fibrin".
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135:
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2012:
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are drugs used to prevent the formation of blood clots, reducing the risk of
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408:
384:
139:
109:
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550:
Illustration comparing normal artery with diseased artery with a blood clot.
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Furie, Bruce; Furie, Barbara (2008). "Mechanisms of
Thrombus Formation".
1000:
906:, is one of the oldest thrombolytic drugs. This drug can be administered
868:
749:
664:
604:
573:
511:
498:, often as a result of blood stasis. They are most commonly found in the
446:
400:
353:
274:
183:
84:
1799:
1372:
Kushner, Abigail; West, William P.; Pillarisetty, Leela
Sharath (2020),
2438:
2403:
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2022:
2004:
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334:
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49:
1406:"Hypercoagulability and thrombotic complications in hemolytic anemias"
712:
646:) – prevents Factor V inactivation leading to increased coagulability.
2428:
2373:
1960:
1143:
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635:
456:
Microclots can cause a number of problems particularly affecting the
333:
intended to stop and prevent further bleeding, but can be harmful in
314:
200:
679:
from broken bones, or other severe traumas. DIC may also be seen in
237:, regular exercise, improved blood flow, management of comorbidities
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showing a thrombus (center of image) within a blood vessel of the
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or red thrombi (characterized by predominance of red blood cells).
2388:
2347:
919:
859:
525:
A mural thrombus can affect any heart chamber. When found in the
196:
117:
1566:
Whalen, Karen; Finkel, Richard S.; Panavelil, Thomas A. (2015).
1348:"Venous thromboembolism (VTE) | McMaster Pathophysiology Review"
1347:
874:
Heparin works by binding to and activating the enzyme inhibitor
325:
protein. The substance making up a thrombus is sometimes called
2332:
1811:
1050:
1004:
930:
847:
812:
799:
Illustration depicting thrombus formation over arterial plaque.
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580:
535:
503:
429:
392:
330:
322:
143:
1199:"Thrombus Formation – Virchow's triad & Types of Thrombi"
943:
631:; any disorder of the blood that predisposes to thrombosis);
499:
445:
consisting of the very small and smallest blood vessels, the
426:
or white thrombi (characterized by predominance of platelets)
388:
379:
Mural thrombi are thrombi that adhere to the wall of a large
756:, a protein normally circulating within the vessels, to the
748:
Platelet activation occurs through injuries that damage the
352:
consisting of the very small and smallest blood vessels the
894:
Once clots have formed, other drugs can be used to promote
490:
Mural thrombi form and adhere on the inner wall of a large
461:
361:
37:"Clot" and "Blood clot" redirect here. For other uses, see
1623:
1624:
Fredriksson, L.; Lawrence, D. A.; Medcalf, R. L. (2016).
991:
Organization and recanalization involves the ingrowth of
1601:
Anatomy & Physiology: The Unity of Form and
Function
1371:
1873:
1110:
83:
Diagram of a thrombus (blood clot) that has blocked a
1565:
1509:
337:, when a clot obstructs blood flow through a healthy
313:. There are two components to a thrombus: aggregated
1789:
1603:(6th ed.). New York: McGraw-Hill. p. 710.
1772:
Muscle
Relaxing Drugs Can Reduce Lethal Blood Clots
1747:(8th ed.). Philadelphia: Saunders/Elsevier.
1510:Harter, K.; Levine, M.; Henderson, S. O. (2015).
752:of the blood vessels, exposing the enzyme called
175:injury to the artery, sepsis or viral infection,
2472:
1313:Robbins & Cotran Pathologic Basis of Disease
1380:, Treasure Island (FL): StatPearls Publishing,
1310:
1570:(6th ed.). Philadelphia: Wolters Kluwer.
1311:Kumar, Vinay; Abbas, Abul; Aster, Jon (2014).
1859:
1784:Air Pollution Triggers Blood Clots – US Study
321:that form a plug, and a mesh of cross-linked
1568:Lippincott Illustrated Reviews: Pharmacology
1139:
1137:
1046:
1044:
1866:
1852:
1469:
74:
1707:
1649:
1535:
1516:The Western Journal of Emergency Medicine
1505:
1503:
1501:
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1421:
1276:
1266:
1171:
1161:
1134:
1078:
1068:
1512:"Anticoagulation Drug Therapy: A Review"
1315:(9th ed.). Philadelphia: Elsevier.
1041:
711:
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545:
2120:
1672:
1598:
1248:
1106:
1104:
1102:
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736:), extended periods of inactivity (see
14:
2473:
1498:
1225:"Medical Definition of micro thrombus"
653:Disseminated intravascular coagulation
387:. They are most commonly found in the
329:. A thrombus is a healthy response to
1847:
1742:
1630:Seminars in Thrombosis and Hemostasis
1561:
1559:
1557:
1555:
1403:
728:), heart valve replacement, a recent
124:), and swelling in the arm and/or leg
1710:Blood Coagulation & Fibrinolysis
1342:
1340:
1306:
1304:
1193:
1191:
1095:
1472:The New England Journal of Medicine
1242:
295:
24:
1743:Kumar, Vinay; et al. (2007).
1552:
1454:
690:
659:using all of the body's available
572:Endothelial injury: Injury to the
25:
2497:
1765:
1337:
1301:
1188:
414:
2220:platelet storage pool deficiency
2172:Heparin-induced thrombocytopenia
1722:10.1097/00001721-199102000-00022
804:
792:
769:
683:. Treatment involves the use of
627:Hypercoagulability (also called
479:
1736:
1701:
1666:
1617:
1592:
1463:
1448:
1397:
1249:Chen W, Pan JY (January 2021).
634:Common causes include: cancer (
506:in the body, more often in the
395:in the body, more often in the
1939:Activated protein C resistance
1365:
1217:
305:, is the final product of the
217:magnetic resonance angiography
30:For the sea sponge genus, see
13:
1:
1528:10.5811/westjem.2014.12.22933
1034:
824:
436:
2033:Trousseau sign of malignancy
1599:Saladin, Kenneth S. (2012).
1457:Human Anatomy and Physiology
1423:10.3324/haematol.2009.013672
1255:Biological Procedures Online
1024:National Blood Clot Alliance
983:Dissolution occurs when the
957:
946:, produces an enzyme called
916:Tissue plasminogen activator
889:
743:
162:Superficial thrombophlebitis
7:
2353:Nonthrombocytopenic purpura
1929:Antithrombin III deficiency
1011:
910:to dissolve blood clots in
880:vitamin K epoxide reductase
716:Mechanism of blood clotting
134:bleeding risks from taking
10:
2502:
2308:Congenital afibrinogenemia
2212:Glanzmann's thrombasthenia
1687:10.2174/138945011797635885
1268:10.1186/s12575-021-00142-y
1070:10.1186/s12933-021-01359-7
828:
483:
43:
36:
29:
2424:Gastrointestinal bleeding
2363:
2320:
2241:
2226:Hermansky–Pudlak syndrome
2185:
2127:
2113:
2041:
2003:
1995:Antiphospholipid syndrome
1976:Essential thrombocythemia
1916:
1909:
1886:
1793:
1459:(11th ed.). Pearson.
988:has been fully developed.
486:Left ventricular thrombus
301:), colloquially called a
284:100,000–300,000 each year
280:
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128:
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2394:Subconjunctival bleeding
2200:Bernard–Soulier syndrome
2163:Upshaw–Schulman syndrome
2137:Thrombocytopenic purpura
1966:Sticky platelet syndrome
1404:Ataga KI (10 May 2020).
902:, an enzyme produced by
541:
510:, and less often in the
399:, and less often in the
256:, unfractionated heparin
166:thrombophlebitis migrans
44:Not to be confused with
2384:Intracranial hemorrhage
1745:Robbins Basic Pathology
1229:www.merriam-webster.com
1163:10.21037/atm.2017.05.15
985:fibrinolytic mechanisms
579:Common causes include:
568:of thrombus formation:
2298:Factor XIII deficiency
2278:Hypoprothrombinemia/II
2273:von Willebrand disease
2231:Gray platelet syndrome
1642:10.1055/s-0036-1586229
1020:(the tendency to clot)
904:streptococcal bacteria
835:Thrombosis prophylaxis
738:deep venous thrombosis
717:
701:
551:
138:, breathing problems,
116:, cramp-like feeling,
2293:Factor XII deficiency
2283:Factor VII deficiency
2101:Renal vein thrombosis
1484:10.1056/NEJMra0801082
936:Haementeria ghilianii
734:myocardial infarction
715:
698:
549:
484:Further information:
39:Clot (disambiguation)
2049:Deep vein thrombosis
1944:Protein S deficiency
1934:Protein C deficiency
1675:Current Drug Targets
974:deep vein thrombosis
886:(PT), respectively.
2288:Factor X deficiency
2177:May–Hegglin anomaly
1954:Prothrombin G20210A
1354:. 26 September 2012
1057:Cardiovasc Diabetol
924:blood–brain barrier
898:or clot breakdown.
869:coagulation cascade
839:Reperfusion therapy
722:atrial fibrillation
685:fresh frozen plasma
2414:Pulmonary hematoma
2321:Signs and symptoms
2096:Pulmonary embolism
1901:Bleeding diathesis
1777:2009-02-04 at the
1455:Marieb, Elaina N.
1203:Thrombosis Adviser
856:pulmonary embolism
726:cardiac arrhythmia
718:
702:
552:
466:respiratory system
366:respiratory system
343:circulatory system
2468:
2467:
2464:
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2316:
2315:
2303:Dysfibrinogenemia
2187:Platelet function
2109:
2108:
1988:Purpura fulminans
1841:
1840:
1754:978-1-4160-2973-1
1681:(12): 1772–1781.
1610:978-0-07-337825-1
1416:(11): 1481–1484.
1352:www.pathophys.org
762:thromboregulation
732:(also known as a
307:blood coagulation
288:
287:
235:smoking cessation
212:Diagnostic method
108:abrupt change in
55:Medical condition
32:Thrombus (sponge)
16:(Redirected from
2493:
2129:Thrombocytopenia
2125:
2124:
2118:
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2074:Lowenberg's sign
1924:Clotting factors
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912:coronary vessels
884:prothrombin time
876:antithrombin III
808:
796:
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700:both directions.
681:pregnant females
508:descending aorta
443:microcirculation
397:descending aorta
350:microcirculation
297:
97:Vascular surgery
78:
58:
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21:
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2409:Hemopericardium
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2243:Clotting factor
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2054:Bancroft's sign
2037:
2028:Virchow's triad
1999:
1949:Factor V Leiden
1905:
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1802:
1779:Wayback Machine
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1113:"Mural Thrombi"
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1018:Thrombogenicity
1014:
960:
952:salivary glands
933:. For example,
892:
841:
829:Main articles:
827:
820:
817:red blood cells
809:
800:
797:
788:
774:
746:
693:
691:Pathophysiology
675:, snake bites,
562:Virchow's triad
556:Virchow's triad
544:
520:atherosclerosis
516:abdominal aorta
488:
482:
451:ischemic events
439:
417:
405:abdominal aorta
319:red blood cells
205:physical trauma
189:hospitalization
120:, passing out (
56:
53:
42:
35:
28:
23:
22:
15:
12:
11:
5:
2499:
2489:
2488:
2483:
2466:
2465:
2462:
2461:
2459:
2458:
2457:
2456:
2448:
2447:
2446:
2441:
2436:
2434:Hemoperitoneum
2431:
2426:
2418:
2417:
2416:
2411:
2406:
2398:
2397:
2396:
2391:
2386:
2381:
2376:
2367:
2365:
2361:
2360:
2358:
2357:
2356:
2355:
2345:
2340:
2335:
2330:
2324:
2322:
2318:
2317:
2314:
2313:
2311:
2310:
2305:
2300:
2295:
2290:
2285:
2280:
2275:
2270:
2269:
2268:
2263:
2258:
2247:
2245:
2239:
2238:
2236:
2235:
2234:
2233:
2228:
2216:
2215:
2214:
2204:
2203:
2202:
2191:
2189:
2183:
2182:
2180:
2179:
2174:
2168:
2167:
2166:
2165:
2160:
2150:
2149:
2148:
2146:Evans syndrome
2133:
2131:
2122:
2115:
2111:
2110:
2107:
2106:
2104:
2103:
2098:
2093:
2092:
2091:
2086:
2081:
2079:Peabody's sign
2076:
2071:
2066:
2061:
2056:
2045:
2043:
2039:
2038:
2036:
2035:
2030:
2025:
2020:
2015:
2009:
2007:
2001:
2000:
1998:
1997:
1992:
1991:
1990:
1980:
1979:
1978:
1973:
1971:Thrombocytosis
1968:
1958:
1957:
1956:
1951:
1946:
1941:
1936:
1931:
1920:
1918:
1911:
1907:
1906:
1904:
1903:
1898:
1893:
1887:
1884:
1883:
1871:
1870:
1863:
1856:
1848:
1839:
1838:
1835:
1834:
1819:
1803:
1798:
1797:
1795:
1794:Classification
1788:
1787:
1781:
1767:
1766:External links
1764:
1761:
1760:
1753:
1735:
1700:
1665:
1636:(2): 154–168.
1616:
1609:
1591:
1576:
1551:
1497:
1462:
1447:
1396:
1364:
1336:
1321:
1300:
1241:
1216:
1187:
1150:Ann Transl Med
1133:
1094:
1039:
1038:
1036:
1033:
1032:
1031:
1026:
1021:
1013:
1010:
1009:
1008:
989:
981:
967:
959:
956:
891:
888:
844:Anticoagulants
826:
823:
822:
821:
810:
803:
801:
798:
791:
789:
775:
768:
745:
742:
692:
689:
650:
649:
648:
647:
625:
624:
623:
598:
597:
596:
564:describes the
543:
540:
527:left ventricle
502:, the largest
481:
478:
438:
435:
434:
433:
427:
416:
415:Classification
413:
391:, the largest
286:
285:
282:
278:
277:
264:
258:
257:
246:Anticoagulants
243:
239:
238:
232:
228:
227:
214:
208:
207:
186:
180:
179:
173:
169:
168:
159:
155:
154:
151:
147:
146:
136:anticoagulants
132:
126:
125:
106:
100:
99:
94:
88:
87:
80:
79:
71:
70:
67:
63:
62:
54:
26:
9:
6:
4:
3:
2:
2498:
2487:
2484:
2482:
2479:
2478:
2476:
2455:
2452:
2451:
2449:
2445:
2444:Hematosalpinx
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2421:
2419:
2415:
2412:
2410:
2407:
2405:
2402:
2401:
2399:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2371:
2369:
2368:
2366:
2362:
2354:
2351:
2350:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2325:
2323:
2319:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2267:
2264:
2262:
2259:
2257:
2254:
2253:
2252:
2249:
2248:
2246:
2244:
2240:
2232:
2229:
2227:
2224:
2223:
2222:
2221:
2217:
2213:
2210:
2209:
2208:
2205:
2201:
2198:
2197:
2196:
2193:
2192:
2190:
2188:
2184:
2178:
2175:
2173:
2170:
2169:
2164:
2161:
2159:
2156:
2155:
2154:
2151:
2147:
2144:
2143:
2142:
2138:
2135:
2134:
2132:
2130:
2126:
2123:
2119:
2116:
2112:
2102:
2099:
2097:
2094:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2069:Louvel's sign
2067:
2065:
2064:Lisker's sign
2062:
2060:
2057:
2055:
2052:
2051:
2050:
2047:
2046:
2044:
2040:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2016:
2014:
2013:Thrombophilia
2011:
2010:
2008:
2006:
2002:
1996:
1993:
1989:
1986:
1985:
1984:
1981:
1977:
1974:
1972:
1969:
1967:
1964:
1963:
1962:
1959:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1926:
1925:
1922:
1921:
1919:
1915:
1912:
1908:
1902:
1899:
1897:
1894:
1892:
1889:
1888:
1885:
1881:
1877:
1874:Disorders of
1869:
1864:
1862:
1857:
1855:
1850:
1849:
1846:
1833:
1829:
1828:
1824:
1820:
1818:
1814:
1813:
1809:
1805:
1804:
1801:
1796:
1792:
1785:
1782:
1780:
1776:
1773:
1770:
1769:
1756:
1750:
1746:
1739:
1731:
1727:
1723:
1719:
1716:(1): 149–52.
1715:
1711:
1704:
1696:
1692:
1688:
1684:
1680:
1676:
1669:
1661:
1657:
1652:
1647:
1643:
1639:
1635:
1631:
1627:
1620:
1612:
1606:
1602:
1595:
1587:
1583:
1579:
1577:9781451191776
1573:
1569:
1562:
1560:
1558:
1556:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1517:
1513:
1506:
1504:
1502:
1493:
1489:
1485:
1481:
1478:(9): 938–49.
1477:
1473:
1466:
1458:
1451:
1443:
1439:
1434:
1429:
1424:
1419:
1415:
1411:
1410:Haematologica
1407:
1400:
1387:
1383:
1379:
1375:
1368:
1353:
1349:
1343:
1341:
1332:
1328:
1324:
1322:9781455726134
1318:
1314:
1307:
1305:
1296:
1292:
1288:
1284:
1279:
1274:
1269:
1264:
1260:
1256:
1252:
1245:
1230:
1226:
1220:
1204:
1200:
1194:
1192:
1183:
1179:
1174:
1169:
1164:
1159:
1155:
1151:
1147:
1140:
1138:
1122:
1118:
1114:
1107:
1105:
1103:
1101:
1099:
1090:
1086:
1081:
1076:
1071:
1066:
1062:
1058:
1054:
1047:
1045:
1040:
1030:
1027:
1025:
1022:
1019:
1016:
1015:
1006:
1002:
998:
994:
993:smooth muscle
990:
986:
982:
979:
975:
971:
968:
965:
964:
963:
955:
953:
949:
945:
942:
938:
937:
932:
927:
925:
921:
917:
913:
909:
908:intravenously
905:
901:
900:Streptokinase
897:
887:
885:
881:
877:
872:
870:
865:
861:
857:
853:
849:
845:
840:
836:
832:
818:
814:
807:
802:
795:
790:
786:
785:H&E stain
782:
778:
772:
767:
766:
765:
763:
759:
758:tissue factor
755:
751:
741:
739:
735:
731:
727:
723:
714:
710:
708:
697:
688:
686:
682:
678:
674:
670:
666:
662:
658:
654:
645:
641:
637:
633:
632:
630:
629:thrombophilia
626:
621:
618:and extended
617:
613:
609:
608:
606:
602:
599:
594:
590:
586:
582:
578:
577:
575:
571:
570:
569:
567:
563:
559:
557:
548:
539:
537:
533:
532:lines of Zahn
528:
523:
521:
517:
513:
509:
505:
501:
497:
496:heart chamber
493:
487:
480:Mural thrombi
477:
475:
471:
467:
463:
459:
454:
452:
448:
444:
431:
428:
425:
422:
421:
420:
412:
410:
409:lines of Zahn
406:
402:
398:
394:
390:
386:
385:heart chamber
382:
377:
375:
371:
367:
363:
359:
355:
351:
346:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
293:
283:
279:
276:
272:
268:
265:
263:
259:
255:
251:
247:
244:
240:
236:
233:
229:
226:
222:
218:
215:
213:
209:
206:
202:
198:
194:
190:
187:
185:
181:
178:
174:
170:
167:
163:
160:
156:
153:c. 3–6 months
152:
148:
145:
141:
140:heart attacks
137:
133:
131:
130:Complications
127:
123:
119:
115:
111:
110:mental status
107:
105:
101:
98:
95:
93:
89:
86:
81:
77:
72:
68:
64:
59:
51:
47:
40:
33:
19:
2454:Hemarthrosis
2218:
2206:
2194:
2084:Pratt's sign
2017:
1896:coagulopathy
1821:
1806:
1744:
1738:
1713:
1709:
1703:
1678:
1674:
1668:
1633:
1629:
1619:
1600:
1594:
1567:
1522:(1): 11–17.
1519:
1515:
1475:
1471:
1465:
1456:
1450:
1413:
1409:
1399:
1389:, retrieved
1377:
1367:
1356:. Retrieved
1351:
1312:
1258:
1254:
1244:
1232:. Retrieved
1228:
1219:
1207:. Retrieved
1202:
1153:
1149:
1124:. Retrieved
1060:
1056:
970:Embolization
961:
934:
928:
896:thrombolysis
893:
873:
852:heart attack
842:
831:Thrombolysis
747:
730:heart attack
719:
703:
657:fibrinolysis
651:
616:broken bones
589:hypertension
566:pathogenesis
560:
553:
524:
492:blood vessel
489:
455:
440:
418:
381:blood vessel
378:
347:
339:blood vessel
326:
302:
298:
291:
289:
184:Risk factors
2207:aggregation
2089:Rose's sign
2059:Homans sign
1891:Coagulation
1234:22 February
1156:(15): 306.
1126:11 February
1001:endothelium
997:fibroblasts
978:lower limbs
750:endothelium
724:(a form of
665:septicaemia
605:tachycardia
601:Hemodynamic
574:endothelium
512:aortic arch
447:capillaries
401:aortic arch
354:capillaries
275:rivaroxaban
66:Other names
2481:Hematology
2475:Categories
2439:Hematocele
2404:Hemothorax
2379:Hemoptysis
2251:Hemophilia
2023:Thrombosis
1391:2020-06-18
1378:StatPearls
1358:2018-11-03
1205:. Bayer AG
1063:(1): 172.
1035:References
1029:Hemorrhoid
825:Prevention
777:Micrograph
754:factor VII
677:fat emboli
642:mutation (
620:air travel
474:long COVID
437:Microclots
374:long COVID
335:thrombosis
311:hemostasis
303:blood clot
262:Medication
254:tinzaparin
231:Prevention
225:venography
221:ultrasound
193:immobility
177:immobility
114:chest pain
85:vein valve
69:Blood clot
50:Thrombosis
27:Blood clot
2429:Hemobilia
2374:Epistaxis
1961:Platelets
1586:881019575
1331:879416939
1295:255608747
1003:into the
958:Prognosis
950:from its
890:Treatment
744:Formation
669:leukaemia
661:platelets
636:leukaemia
472:, and in
315:platelets
242:Treatment
201:pregnancy
92:Specialty
2486:Ischemia
2420:abdomen
2343:Petechia
2338:Hematoma
2328:Bleeding
2195:adhesion
2121:By cause
2114:Bleeding
2018:Thrombus
1917:By cause
1910:Clotting
1880:clotting
1876:bleeding
1775:Archived
1695:21707475
1660:27677179
1546:25671002
1492:18753650
1442:19880774
1386:30969519
1287:33472576
1261:(1): 4.
1209:20 March
1182:28856146
1121:30484999
1089:34425843
1012:See also
948:hementin
864:warfarin
781:placenta
667:, acute
640:factor V
593:atheroma
470:COVID-19
424:Arterial
370:COVID-19
309:step in
292:thrombus
271:edoxaban
267:apixaban
250:edoxaban
150:Duration
104:Symptoms
61:Thrombus
46:Embolism
2389:Hyphema
2364:By site
2348:Purpura
2042:By site
1730:1772982
1651:5848490
1537:4307693
1433:2770956
1278:7816139
1173:5555985
1080:8381139
995:cells,
976:in the
920:plasmin
860:Heparin
707:embolus
585:smoking
464:of the
460:in the
458:alveoli
441:In the
372:and in
364:of the
360:in the
358:alveoli
348:In the
341:in the
299:thrombi
197:obesity
122:syncope
118:fatigue
2450:joint
2400:torso
2333:Bruise
2256:A/VIII
1751:
1728:
1693:
1658:
1648:
1607:
1584:
1574:
1544:
1534:
1490:
1440:
1430:
1384:
1329:
1319:
1293:
1285:
1275:
1180:
1170:
1119:
1087:
1077:
1005:fibrin
941:Amazon
931:fibrin
848:stroke
837:, and
813:fibrin
644:Leiden
612:trauma
581:trauma
536:fibrin
504:artery
430:Venous
393:artery
331:injury
323:fibrin
281:Deaths
273:, and
223:, and
172:Causes
144:stroke
2370:head
2005:Clots
1817:Xxx.x
1291:S2CID
944:leech
939:, an
673:shock
542:Cause
500:aorta
462:lungs
389:aorta
362:lungs
327:cruor
158:Types
2266:C/XI
2261:B/IX
1878:and
1827:9-CM
1749:ISBN
1726:PMID
1691:PMID
1656:PMID
1605:ISBN
1582:OCLC
1572:ISBN
1542:PMID
1488:PMID
1438:PMID
1382:PMID
1327:OCLC
1317:ISBN
1283:PMID
1236:2023
1211:2020
1178:PMID
1128:2022
1117:PMID
1085:PMID
999:and
862:and
854:and
815:and
317:and
164:and
18:Clot
2158:TTP
2141:ITP
1983:DIC
1832:xxx
1823:ICD
1808:ICD
1718:doi
1683:doi
1646:PMC
1638:doi
1532:PMC
1524:doi
1480:doi
1476:359
1428:PMC
1418:doi
1273:PMC
1263:doi
1168:PMC
1158:doi
1075:PMC
1065:doi
638:),
514:or
494:or
403:or
383:or
296:pl.
48:or
2477::
2153:TM
2139::
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
