309:
286:
208:
183:
1235:. Without the CDC7 gene DNA synthesis is stopped, and the ESCs do not grow. With the loss of function of Cdc7 in ESCs the S phase is stopped at the G2/M checkpoint. Recombinational repair (RR) is done at this point to try to fix the CDC7 gene so replication can occur. By copying and replacing the altered area with a very similar area on the sister homolog chromosome, the gene can be replicated as if nothing was ever wrong on the chromosome. However, when the cell enters this arrested state, levels of
560:
315:
214:
4565:
1228:
the G1/S transition of the cell cycle is higher than the concentration at the M/G1 transition. This tells us that Dbf4 is expressed around the time for replication; right after replication is over, the protein levels drop. Because the two proteins, Cdc7 and Dbf4, must form a complex before activating the MCM complex, the regulation of one protein is sufficient for both.
1227:
The gene, CDC7, is involved in the regulation of cell cycle because of the gene product Cdc7 kinase. The protein is expressed at constant levels throughout the cell cycle. The gene coding for the Dbf4 or ASK protein is regulated during the different phases of cell cycle. The concentration of Dbf4 at
1214:(as explained in the Cdc7 and Replication section below). Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. It has been suggested that the protein is essential for initiation of
50:
1218:
and that it plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing.
1274:
activity of the MCM complex at the origin of replication. This is most likely due to the change in conformation allowing the remainder of replication machinery proteins to be loaded. DNA replication can begin after all the necessary proteins are in place.
1197:
The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. The protein is a serine-threonine kinase that is activated by another protein called either
322:
221:
1259:). Mitosis occurs during M phase of the cell cycle and has a number of stages; telophase is the end stage of mitosis when the replication of chromosomes is complete, but separation has not occurred.
1231:
It has been shown that CDC7 is important for replication. There are several ways its expression can be altered that leads to problems. In mouse embryonic stem cells (ESCs), Cdc7 is needed for
2428:
2713:
1884:
Hess GF, Drong RF, Weiland KL, Slightom JL, Sclafani RA, Hollingsworth RE (1998). "A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines".
2176:
Kurita M, Suzuki H, Masai H, Mizumoto K, Ogata E, Nishimoto I, Aiso S, Matsuoka M (2004). "Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest".
2001:"Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 bY Cdks"
2421:
853:
144:
2414:
1651:
Kneissl M, PĂĽtter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells".
834:
2312:"The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen"
2621:
1790:"Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7"
1497:"Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7"
1915:"A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells"
1688:"A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells"
2112:
Kneissl M, PĂĽtter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells".
3966:
1564:
Kim JM, Yamada M, Masai H (November 2003). "Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development".
1418:
1400:
1270:(ORC). Since Cdc7 is attached to the Dbf4 protein the entire complex is held in place during replication. This activation of MCM 2 leads to
3169:
2472:
4117:
2855:
2742:
1100:
3130:
1093:
4103:
3922:
3568:
3164:
3154:
3149:
2459:
2441:
4205:
4086:
1547:
3792:
2661:
1266:(Cdk), phosphorylates the pre-RC which activates it at the G1/S transition. The Dbf4 tethers itself to part of the pre-RC, the
1247:
After chromatin undergoes changes in telophase of mitosis, the hexameric protein complex of MCM proteins 2-7 forms part of the
3856:
2831:
1383:
4585:
4112:
47:
2646:
1362:
3844:
2355:"CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein"
4169:
4284:
3101:
3091:
2776:
2406:
308:
3783:
4052:
3724:
3086:
3077:
1387:
1366:
285:
4590:
2242:"A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes"
898:
2207:"A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases"
4440:
3467:
2964:
2955:
2612:
2558:
2069:
Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C (2002).
879:
2655:
2275:
Montagnoli A, Valsasina B, Brotherton D, Troiani S, Rainoldi S, Tenca P, Molinari A, Santocanale C (2006).
207:
182:
124:
1284:
4555:
3679:
3497:
2993:
1267:
1207:
321:
220:
4541:
4528:
4515:
4502:
4489:
4476:
4463:
4425:
3669:
3664:
3659:
3649:
3644:
3639:
3629:
3424:
3199:
2795:
314:
213:
111:
4435:
4389:
4332:
3892:
3883:
3834:
2600:
2445:
1072:
1068:
1064:
1039:
1035:
1005:
1001:
997:
972:
968:
132:
2143:"Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells"
4337:
4192:
3615:
1263:
1248:
1076:
1043:
1009:
976:
1601:"Control of DNA replication: regulation and activation of eukaryotic replicative helicase, MCM"
1833:"Identification and characterization of a human protein kinase related to budding yeast Cdc7p"
1438:"Identification and characterization of a human protein kinase related to budding yeast Cdc7p"
4358:
4277:
2891:
4430:
3458:
2366:
2310:
Gérard A, Koundrioukoff S, Ramillon V, Sergère JC, Mailand N, Quivy JP, Almouzni G (2006).
1958:"Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication"
1844:
1737:"Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication"
1449:
196:
2141:
Montagnoli A, Tenca P, Sola F, Carpani D, Brotherton D, Albanese C, Santocanale C (2004).
152:
8:
4394:
3567:
2458:
2370:
1848:
1686:
Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (July 1999).
1453:
4595:
4327:
4069:
4023:
2389:
2354:
2336:
2311:
1982:
1957:
1814:
1789:
1761:
1736:
1521:
1496:
1182:
156:
2125:
2095:
2070:
1897:
1664:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
672:
667:
662:
657:
652:
636:
631:
626:
621:
616:
611:
606:
601:
3329:
3038:
2436:
2394:
2341:
2298:
2263:
2228:
2193:
2164:
2129:
2100:
2057:
2022:
1987:
1944:
1939:
1914:
1901:
1872:
1867:
1832:
1819:
1766:
1717:
1712:
1687:
1668:
1622:
1581:
1526:
1477:
1472:
1437:
104:
40:
136:
4373:
4368:
4342:
4270:
3067:
3058:
2988:
2979:
2925:
2916:
2573:
2384:
2374:
2331:
2323:
2288:
2253:
2218:
2185:
2154:
2121:
2090:
2082:
2047:
2012:
1977:
1969:
1934:
1926:
1913:
Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (1999).
1893:
1862:
1852:
1809:
1801:
1756:
1748:
1707:
1699:
1660:
1612:
1573:
1516:
1508:
1467:
1457:
401:
332:
276:
231:
2159:
2142:
4420:
4404:
4317:
3748:
2819:
2814:
2809:
1577:
1215:
1178:
376:
160:
1423:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1405:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4569:
4458:
4399:
2189:
1973:
1805:
1752:
1512:
1189:
evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.
477:
1617:
1600:
4579:
4363:
4322:
2804:
2327:
1857:
1462:
1236:
588:
2872:
2379:
2277:"Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases"
537:
415:
4312:
3743:
2568:
2398:
2345:
2302:
2293:
2276:
2267:
2232:
2223:
2206:
2205:
Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K, Masai H (2005).
2197:
2168:
2133:
2104:
2086:
2061:
2052:
2035:
2026:
2017:
2000:
1991:
1948:
1770:
1721:
1672:
1626:
1585:
559:
394:
173:
1930:
1905:
1876:
1823:
1703:
1530:
1481:
1262:
The Cdc7/Dbf4 kinase complex, along with another serine-threonine kinase,
1140:
1135:
4536:
4471:
4307:
3949:
3581:
3521:
3404:
3324:
3048:
1232:
943:
924:
2258:
2241:
1210:(MCM) protein complex allowing for the initiation of DNA replication in
4037:
2511:
1206:
or ASK in mammals. The Cdc7/Dbf4 complex adds a phosphate group to the
1175:
1171:
293:
190:
140:
81:
77:
73:
69:
4510:
4484:
2998:
1239:
may increase. These increased levels of p53 may initiate cell death.
1186:
798:
360:
347:
259:
246:
148:
2274:
4564:
3354:
3249:
3244:
3239:
2204:
1271:
1124:
2714:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2309:
4013:
3991:
3986:
3976:
3971:
3773:
3768:
3763:
3758:
3753:
3738:
3733:
3384:
3349:
2588:
2583:
2578:
1548:"Entrez Gene: CDC7 cell division cycle 7 homolog (S. cerevisiae)"
1211:
910:
865:
783:
779:
1251:(pre-RC) by binding to the chromatin and other aiding proteins (
128:
4523:
4293:
4243:
4238:
4233:
4228:
4223:
4218:
4213:
4164:
4159:
4154:
4149:
4144:
4127:
4122:
3996:
3981:
3932:
3927:
3912:
3907:
3902:
3897:
3871:
3866:
3861:
3849:
3827:
3822:
3714:
3689:
3364:
3189:
3184:
3179:
3174:
3159:
3003:
2940:
2935:
2930:
2906:
2732:
2727:
2701:
2696:
2691:
2681:
2676:
2666:
2506:
2437:
1339:
1167:
1156:
1108:
820:
568:
2068:
4497:
4139:
4132:
4042:
3939:
3839:
3817:
3812:
3807:
3802:
3797:
3709:
3704:
3699:
3694:
3684:
3654:
3634:
3511:
3506:
3487:
3482:
3472:
3448:
3443:
3438:
3414:
3409:
3399:
3394:
3389:
3379:
3359:
3344:
3339:
3334:
3314:
3309:
3299:
3294:
3289:
3284:
3279:
3269:
3264:
3259:
3254:
3234:
3229:
3224:
3219:
3214:
3209:
3194:
3144:
3139:
3033:
3028:
3023:
3018:
3013:
3008:
2969:
2901:
2896:
2845:
2840:
2766:
2761:
2756:
2722:
2516:
2501:
2496:
2491:
2486:
2481:
2033:
1321:
1315:
1999:
Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K (2000).
744:
positive regulation of G2/M transition of mitotic cell cycle
4032:
3959:
3954:
3944:
3917:
3674:
3624:
3605:
3600:
3595:
3590:
3545:
3540:
3535:
3530:
3477:
3433:
3374:
3369:
3319:
3304:
3274:
3204:
3120:
3115:
3110:
3043:
2945:
2886:
2881:
2785:
2751:
2636:
2631:
2626:
2595:
2563:
2551:
2546:
2541:
2531:
2526:
2036:"Biochemical activities associated with mouse Mcm2 protein"
1309:
1303:
1297:
1291:
1256:
1252:
1199:
1163:
4262:
2140:
4001:
2536:
2521:
2175:
2111:
1650:
704:
positive regulation of nuclear cell cycle DNA replication
4191:
2071:"Drf1, a novel regulatory subunit for human Cdc7 kinase"
1883:
699:
double-strand break repair via break-induced replication
384:
1955:
1912:
1735:
Jiang W, McDonald D, Hope TJ, Hunter T (October 1999).
1734:
1685:
4553:
549:
2034:
Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001).
1998:
734:
positive regulation of cell population proliferation
2353:Cho WH, Lee YJ, Kong SI, Hurwitz J, Lee JK (2006).
1379:
1377:
1375:
1358:
1356:
1354:
2352:
331:
230:
4577:
1956:Jiang W, McDonald D, Hope TJ, Hunter T (1999).
1646:
1644:
1642:
1640:
1638:
1636:
1372:
1351:
16:Protein-coding gene in the species Homo sapiens
2239:
1563:
1559:
1557:
1384:GRCm38: Ensembl release 89: ENSMUSG00000029283
4278:
2473:Non-specific serine/threonine protein kinases
2422:
1787:
1494:
1728:
1679:
1633:
1598:
1153:Cell division cycle 7-related protein kinase
1830:
1592:
1554:
1435:
1363:GRCh38: Ensembl release 89: ENSG00000097046
4285:
4271:
2856:Goodpasture-antigen-binding protein kinase
2429:
2415:
1488:
1429:
759:negative regulation of G0 to G1 transition
3569:Serine/threonine-specific protein kinases
2743:(isocitrate dehydrogenase (NADP+)) kinase
2460:Serine/threonine-specific protein kinases
2442:Serine/threonine-specific protein kinases
2388:
2378:
2335:
2292:
2257:
2222:
2158:
2094:
2051:
2016:
1981:
1938:
1866:
1856:
1813:
1760:
1711:
1616:
1520:
1471:
1461:
115:, CDC7L1, HsHsk1, hucell division cycle 7
4104:Receptor protein serine/threonine kinase
1542:
1540:
1222:
627:protein serine/threonine kinase activity
4087:Low-density-lipoprotein receptor kinase
4578:
4266:
4190:
3566:
2832:Fas-activated serine/threonine kinase
2457:
2410:
1537:
764:G1/S transition of mitotic cell cycle
336:
297:
292:
235:
194:
189:
4204:
4113:Bone morphogenetic protein receptors
1495:Sato N, Arai K, Masai H (Sep 1997).
2647:Dephospho-(reductase kinase) kinase
13:
3102:G-protein coupled receptor kinases
1780:
769:peptidyl-threonine phosphorylation
14:
4607:
3092:Beta adrenergic receptor kinase-2
2777:(tyrosine 3-monooxygenase) kinase
1170:is involved in regulation of the
1159:that in humans is encoded by the
4563:
3784:Mitogen-activated protein kinase
1788:Sato N, Arai K, Masai H (1997).
558:
320:
313:
307:
284:
219:
212:
206:
181:
4170:Anti-MĂĽllerian hormone receptor
4053:(acetyl-CoA carboxylase) kinase
3725:(RNA-polymerase)-subunit kinase
3087:Beta adrenergic receptor kinase
3078:Beta adrenergic receptor kinase
1599:Masai H, You Z, Arai K (2005).
1278:
729:peptidyl-serine phosphorylation
3793:Extracellular signal-regulated
1436:Jiang W, Hunter T (Feb 1998).
1411:
1393:
1242:
1181:. The gene CDC7 appears to be
569:More reference expression data
538:More reference expression data
462:right hemisphere of cerebellum
1:
3857:P38 mitogen-activated protein
2956:cGMP-dependent protein kinase
2917:cAMP-dependent protein kinase
2613:Pyruvate dehydrogenase kinase
2559:Ataxia telangiectasia mutated
2240:Grishina I, Lattes B (2005).
2178:Biochem. Biophys. Res. Commun
2160:10.1158/0008-5472.CAN-04-1547
2126:10.1016/S0022-2836(03)00079-2
1898:10.1016/S0378-1119(98)00094-8
1665:10.1016/S0022-2836(03)00079-2
1345:
305:
204:
2656:AMP-activated protein kinase
2359:Proc. Natl. Acad. Sci. U.S.A
1837:Proc. Natl. Acad. Sci. U.S.A
1578:10.1016/j.mrfmmm.2003.08.008
1442:Proc. Natl. Acad. Sci. U.S.A
7:
4586:Genes on human chromosome 1
4292:
3571:(EC 2.7.11.21-EC 2.7.11.30)
1192:
689:cell cycle phase transition
10:
4612:
3498:Elongation factor 2 kinase
2462:(EC 2.7.11.1-EC 2.7.11.20)
2190:10.1016/j.bbrc.2004.09.083
1831:Jiang W, Hunter T (1997).
1328:
1268:origin recognition complex
1208:minichromosome maintenance
724:DNA replication initiation
4449:
4441:Michaelis–Menten kinetics
4413:
4382:
4351:
4300:
4200:
4186:
4102:
4085:
4068:
4051:
4022:
3893:MAP kinase kinase kinases
3882:
3782:
3723:
3614:
3580:
3576:
3562:
3520:
3496:
3457:
3425:Myosin light-chain kinase
3423:
3131:Ca2+/calmodulin-dependent
3129:
3100:
3076:
3057:
2978:
2954:
2915:
2871:
2854:
2830:
2796:Myosin-heavy-chain kinase
2794:
2775:
2741:
2712:
2645:
2611:
2471:
2467:
2453:
1618:10.1080/15216540500092419
1419:"Mouse PubMed Reference:"
1401:"Human PubMed Reference:"
1139:
1134:
1130:
1123:
1107:
1101:Chr 5: 107.11 – 107.13 Mb
1088:
1061:
1057:
1032:
1028:
1021:
994:
990:
965:
961:
954:
941:
937:
922:
918:
909:
896:
892:
877:
873:
864:
851:
847:
832:
828:
819:
804:
797:
793:
777:
587:
583:
566:
557:
548:
535:
500:medullary collecting duct
484:
475:
422:
413:
383:
375:
371:
354:
341:
304:
283:
274:
270:
253:
240:
203:
180:
171:
167:
122:
119:
109:
102:
97:
66:
61:
44:
39:
34:
30:
26:
21:
4333:Diffusion-limited enzyme
4193:Dual-specificity kinases
2328:10.1038/sj.embor.7400750
1974:10.1093/emboj/18.20.5703
1858:10.1073/pnas.94.26.14320
1806:10.1093/emboj/16.14.4340
1753:10.1093/emboj/18.20.5703
1513:10.1093/emboj/16.14.4340
1463:10.1073/pnas.94.26.14320
1204:Saccharomyces cerevisiae
754:regulation of cell shape
3616:Cyclin-dependent kinase
2380:10.1073/pnas.0604990103
1283:CDC7 has been shown to
1264:cyclin-dependent kinase
1249:pre-replication complex
719:protein phosphorylation
607:protein kinase activity
2294:10.1074/jbc.M512921200
2224:10.1074/jbc.M411653200
2053:10.1074/jbc.M106861200
2018:10.1074/jbc.M002713200
1094:Chr 1: 91.5 – 91.53 Mb
4591:Cell cycle regulators
4426:Eadie–Hofstee diagram
4359:Allosteric regulation
1931:10.1128/MCB.19.7.5083
1704:10.1128/MCB.19.7.5083
1223:Cell cycle regulation
458:cerebellar hemisphere
4436:Lineweaver–Burk plot
3459:Phosphorylase kinase
2087:10.1093/emboj/cdf290
663:intercellular bridge
602:transferase activity
299:Chromosome 5 (mouse)
197:Chromosome 1 (human)
62:List of PDB id codes
35:Available structures
2371:2006PNAS..10311521C
2259:10.4161/cc.4.8.1918
1849:1997PNAS...9414320J
1454:1997PNAS...9414320J
446:ganglionic eminence
4395:Enzyme superfamily
4328:Enzyme promiscuity
4070:Tropomyosin kinase
4024:Tau-protein kinase
899:ENSMUSG00000029283
682:Biological process
646:Cellular component
612:nucleotide binding
595:Molecular function
450:buccal mucosa cell
4551:
4550:
4260:
4259:
4256:
4255:
4252:
4251:
4182:
4181:
4178:
4177:
3558:
3557:
3554:
3553:
3039:Protein kinase N1
2994:Protein kinase Cζ
1150:
1149:
1146:
1145:
1119:
1118:
1084:
1083:
1051:
1050:
1017:
1016:
984:
983:
950:
949:
931:
930:
905:
904:
886:
885:
860:
859:
841:
840:
789:
788:
617:metal ion binding
579:
578:
575:
574:
544:
543:
531:
530:
469:
468:
367:
366:
266:
265:
93:
92:
89:
88:
45:Ortholog search:
4603:
4568:
4567:
4559:
4431:Hanes–Woolf plot
4374:Enzyme activator
4369:Enzyme inhibitor
4343:Enzyme catalysis
4287:
4280:
4273:
4264:
4263:
4202:
4201:
4188:
4187:
3835:C-Jun N-terminal
3578:
3577:
3564:
3563:
3068:Rhodopsin kinase
3059:Rhodopsin kinase
2989:Protein kinase C
2980:Protein kinase C
2965:Protein kinase G
2926:Protein kinase A
2537:Protein kinase B
2469:
2468:
2455:
2454:
2431:
2424:
2417:
2408:
2407:
2402:
2392:
2382:
2349:
2339:
2306:
2296:
2287:(15): 10281–90.
2271:
2261:
2236:
2226:
2217:(13): 13062–70.
2201:
2172:
2162:
2137:
2108:
2098:
2065:
2055:
2046:(46): 42744–52.
2030:
2020:
2011:(37): 29042–52.
1995:
1985:
1952:
1942:
1909:
1880:
1870:
1860:
1827:
1817:
1775:
1774:
1764:
1732:
1726:
1725:
1715:
1683:
1677:
1676:
1648:
1631:
1630:
1620:
1596:
1590:
1589:
1561:
1552:
1551:
1544:
1535:
1534:
1524:
1492:
1486:
1485:
1475:
1465:
1433:
1427:
1426:
1415:
1409:
1408:
1397:
1391:
1381:
1370:
1360:
1174:at the point of
1132:
1131:
1103:
1096:
1079:
1055:
1054:
1046:
1026:
1025:
1022:RefSeq (protein)
1012:
988:
987:
979:
959:
958:
935:
934:
916:
915:
890:
889:
871:
870:
845:
844:
826:
825:
795:
794:
585:
584:
571:
562:
555:
554:
540:
504:primitive streak
480:
478:Top expressed in
473:
472:
438:ventricular zone
430:endothelial cell
426:secondary oocyte
418:
416:Top expressed in
411:
410:
390:
389:
373:
372:
363:
350:
339:
324:
317:
311:
300:
288:
272:
271:
262:
249:
238:
223:
216:
210:
199:
185:
169:
168:
163:
161:CDC7 - orthologs
114:
107:
84:
59:
58:
53:
32:
31:
19:
18:
4611:
4610:
4606:
4605:
4604:
4602:
4601:
4600:
4576:
4575:
4574:
4562:
4554:
4552:
4547:
4459:Oxidoreductases
4445:
4421:Enzyme kinetics
4409:
4405:List of enzymes
4378:
4347:
4318:Catalytic triad
4296:
4291:
4261:
4248:
4196:
4174:
4098:
4081:
4064:
4047:
4018:
3878:
3778:
3749:P70-S6 Kinase 1
3719:
3610:
3572:
3550:
3516:
3492:
3453:
3419:
3125:
3096:
3072:
3053:
2974:
2950:
2911:
2867:
2850:
2826:
2820:Aurora C kinase
2815:Aurora B kinase
2810:Aurora A kinase
2790:
2771:
2737:
2708:
2641:
2607:
2463:
2449:
2435:
2405:
2365:(31): 11521–6.
2081:(12): 3171–81.
1968:(20): 5703–13.
1919:Mol. Cell. Biol
1843:(26): 14320–5.
1800:(14): 4340–51.
1783:
1781:Further reading
1778:
1747:(20): 5703–13.
1733:
1729:
1692:Mol. Cell. Biol
1684:
1680:
1649:
1634:
1611:(4–5): 323–35.
1597:
1593:
1562:
1555:
1546:
1545:
1538:
1507:(14): 4340–51.
1493:
1489:
1448:(26): 14320–5.
1434:
1430:
1417:
1416:
1412:
1399:
1398:
1394:
1382:
1373:
1361:
1352:
1348:
1331:
1281:
1245:
1225:
1216:DNA replication
1195:
1179:DNA replication
1141:View/Edit Mouse
1136:View/Edit Human
1099:
1092:
1089:Location (UCSC)
1075:
1071:
1067:
1063:
1042:
1038:
1034:
1008:
1004:
1000:
996:
975:
971:
967:
880:ENSG00000097046
773:
714:DNA replication
694:phosphorylation
677:
673:mitotic spindle
641:
632:protein binding
622:kinase activity
567:
536:
527:
522:
518:
514:
510:
506:
502:
498:
494:
490:
476:
465:
460:
456:
452:
448:
444:
440:
436:
432:
428:
414:
358:
345:
337:
327:
326:
325:
318:
298:
275:Gene location (
257:
244:
236:
226:
225:
224:
217:
195:
172:Gene location (
123:
110:
103:
68:
46:
17:
12:
11:
5:
4609:
4599:
4598:
4593:
4588:
4573:
4572:
4549:
4548:
4546:
4545:
4532:
4519:
4506:
4493:
4480:
4467:
4453:
4451:
4447:
4446:
4444:
4443:
4438:
4433:
4428:
4423:
4417:
4415:
4411:
4410:
4408:
4407:
4402:
4397:
4392:
4386:
4384:
4383:Classification
4380:
4379:
4377:
4376:
4371:
4366:
4361:
4355:
4353:
4349:
4348:
4346:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4304:
4302:
4298:
4297:
4290:
4289:
4282:
4275:
4267:
4258:
4257:
4254:
4253:
4250:
4249:
4247:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4210:
4208:
4198:
4197:
4184:
4183:
4180:
4179:
4176:
4175:
4173:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4136:
4135:
4130:
4125:
4120:
4109:
4107:
4106:(EC 2.7.11.30)
4100:
4099:
4097:
4096:
4092:
4090:
4089:(EC 2.7.11.29)
4083:
4082:
4080:
4079:
4075:
4073:
4072:(EC 2.7.11.28)
4066:
4065:
4063:
4062:
4058:
4056:
4055:(EC 2.7.11.27)
4049:
4048:
4046:
4045:
4040:
4035:
4029:
4027:
4026:(EC 2.7.11.26)
4020:
4019:
4017:
4016:
4011:
4006:
4005:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3964:
3963:
3962:
3957:
3952:
3947:
3937:
3936:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3889:
3887:
3886:(EC 2.7.11.25)
3880:
3879:
3877:
3876:
3875:
3874:
3869:
3864:
3854:
3853:
3852:
3847:
3842:
3832:
3831:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3789:
3787:
3786:(EC 2.7.11.24)
3780:
3779:
3777:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3730:
3728:
3727:(EC 2.7.11.23)
3721:
3720:
3718:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3621:
3619:
3618:(EC 2.7.11.22)
3612:
3611:
3609:
3608:
3603:
3598:
3593:
3587:
3585:
3584:(EC 2.7.11.21)
3574:
3573:
3560:
3559:
3556:
3555:
3552:
3551:
3549:
3548:
3543:
3538:
3533:
3527:
3525:
3524:(EC 2.7.11.21)
3518:
3517:
3515:
3514:
3509:
3503:
3501:
3500:(EC 2.7.11.20)
3494:
3493:
3491:
3490:
3485:
3480:
3475:
3470:
3464:
3462:
3461:(EC 2.7.11.19)
3455:
3454:
3452:
3451:
3446:
3441:
3436:
3430:
3428:
3427:(EC 2.7.11.18)
3421:
3420:
3418:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3242:
3237:
3232:
3227:
3222:
3217:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3136:
3134:
3133:(EC 2.7.11.17)
3127:
3126:
3124:
3123:
3118:
3113:
3107:
3105:
3104:(EC 2.7.11.16)
3098:
3097:
3095:
3094:
3089:
3083:
3081:
3080:(EC 2.7.11.15)
3074:
3073:
3071:
3070:
3064:
3062:
3061:(EC 2.7.11.14)
3055:
3054:
3052:
3051:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2985:
2983:
2982:(EC 2.7.11.13)
2976:
2975:
2973:
2972:
2967:
2961:
2959:
2958:(EC 2.7.11.12)
2952:
2951:
2949:
2948:
2943:
2938:
2933:
2928:
2922:
2920:
2919:(EC 2.7.11.11)
2913:
2912:
2910:
2909:
2904:
2899:
2894:
2889:
2884:
2878:
2876:
2875:(EC 2.7.11.10)
2869:
2868:
2866:
2865:
2861:
2859:
2852:
2851:
2849:
2848:
2843:
2837:
2835:
2828:
2827:
2825:
2824:
2823:
2822:
2817:
2812:
2801:
2799:
2792:
2791:
2789:
2788:
2782:
2780:
2773:
2772:
2770:
2769:
2764:
2759:
2754:
2748:
2746:
2739:
2738:
2736:
2735:
2730:
2725:
2719:
2717:
2710:
2709:
2707:
2706:
2705:
2704:
2699:
2694:
2686:
2685:
2684:
2679:
2671:
2670:
2669:
2664:
2652:
2650:
2643:
2642:
2640:
2639:
2634:
2629:
2624:
2618:
2616:
2609:
2608:
2606:
2605:
2604:
2603:
2593:
2592:
2591:
2586:
2581:
2576:
2566:
2561:
2556:
2555:
2554:
2549:
2544:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2478:
2476:
2465:
2464:
2451:
2450:
2434:
2433:
2426:
2419:
2411:
2404:
2403:
2350:
2307:
2272:
2237:
2202:
2173:
2153:(19): 7110–6.
2138:
2109:
2066:
2031:
1996:
1953:
1925:(7): 5083–95.
1910:
1881:
1828:
1784:
1782:
1779:
1777:
1776:
1727:
1698:(7): 5083–95.
1678:
1632:
1591:
1572:(1–2): 29–40.
1553:
1536:
1487:
1428:
1410:
1392:
1371:
1349:
1347:
1344:
1343:
1342:
1336:
1335:
1330:
1327:
1326:
1325:
1319:
1313:
1307:
1301:
1295:
1280:
1277:
1244:
1241:
1224:
1221:
1194:
1191:
1148:
1147:
1144:
1143:
1138:
1128:
1127:
1121:
1120:
1117:
1116:
1114:
1112:
1105:
1104:
1097:
1090:
1086:
1085:
1082:
1081:
1059:
1058:
1052:
1049:
1048:
1030:
1029:
1023:
1019:
1018:
1015:
1014:
992:
991:
985:
982:
981:
963:
962:
956:
952:
951:
948:
947:
939:
938:
932:
929:
928:
920:
919:
913:
907:
906:
903:
902:
894:
893:
887:
884:
883:
875:
874:
868:
862:
861:
858:
857:
849:
848:
842:
839:
838:
830:
829:
823:
817:
816:
811:
806:
802:
801:
791:
790:
787:
786:
775:
774:
772:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
685:
683:
679:
678:
676:
675:
670:
665:
660:
655:
649:
647:
643:
642:
640:
639:
634:
629:
624:
619:
614:
609:
604:
598:
596:
592:
591:
581:
580:
577:
576:
573:
572:
564:
563:
552:
546:
545:
542:
541:
533:
532:
529:
528:
526:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
482:
481:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
407:
406:
398:
387:
381:
380:
377:RNA expression
369:
368:
365:
364:
356:
352:
351:
343:
340:
335:
329:
328:
319:
312:
306:
302:
301:
296:
290:
289:
281:
280:
268:
267:
264:
263:
255:
251:
250:
242:
239:
234:
228:
227:
218:
211:
205:
201:
200:
193:
187:
186:
178:
177:
165:
164:
121:
117:
116:
108:
100:
99:
95:
94:
91:
90:
87:
86:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
4608:
4597:
4594:
4592:
4589:
4587:
4584:
4583:
4581:
4571:
4566:
4561:
4560:
4557:
4543:
4539:
4538:
4533:
4530:
4526:
4525:
4520:
4517:
4513:
4512:
4507:
4504:
4500:
4499:
4494:
4491:
4487:
4486:
4481:
4478:
4474:
4473:
4468:
4465:
4461:
4460:
4455:
4454:
4452:
4448:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4416:
4412:
4406:
4403:
4401:
4400:Enzyme family
4398:
4396:
4393:
4391:
4388:
4387:
4385:
4381:
4375:
4372:
4370:
4367:
4365:
4364:Cooperativity
4362:
4360:
4357:
4356:
4354:
4350:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4323:Oxyanion hole
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4305:
4303:
4299:
4295:
4288:
4283:
4281:
4276:
4274:
4269:
4268:
4265:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4211:
4209:
4207:
4203:
4199:
4194:
4189:
4185:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4115:
4114:
4111:
4110:
4108:
4105:
4101:
4094:
4093:
4091:
4088:
4084:
4077:
4076:
4074:
4071:
4067:
4060:
4059:
4057:
4054:
4050:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4028:
4025:
4021:
4015:
4012:
4010:
4007:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3969:
3968:
3965:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3941:
3938:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3895:
3894:
3891:
3890:
3888:
3885:
3881:
3873:
3870:
3868:
3865:
3863:
3860:
3859:
3858:
3855:
3851:
3848:
3846:
3843:
3841:
3838:
3837:
3836:
3833:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3794:
3791:
3790:
3788:
3785:
3781:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3731:
3729:
3726:
3722:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3622:
3620:
3617:
3613:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3588:
3586:
3583:
3579:
3575:
3570:
3565:
3561:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3528:
3526:
3523:
3519:
3513:
3510:
3508:
3505:
3504:
3502:
3499:
3495:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3465:
3463:
3460:
3456:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3431:
3429:
3426:
3422:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3135:
3132:
3128:
3122:
3119:
3117:
3114:
3112:
3109:
3108:
3106:
3103:
3099:
3093:
3090:
3088:
3085:
3084:
3082:
3079:
3075:
3069:
3066:
3065:
3063:
3060:
3056:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2986:
2984:
2981:
2977:
2971:
2968:
2966:
2963:
2962:
2960:
2957:
2953:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2923:
2921:
2918:
2914:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2879:
2877:
2874:
2870:
2863:
2862:
2860:
2858:(EC 2.7.11.9)
2857:
2853:
2847:
2844:
2842:
2839:
2838:
2836:
2834:(EC 2.7.11.8)
2833:
2829:
2821:
2818:
2816:
2813:
2811:
2808:
2807:
2806:
2805:Aurora kinase
2803:
2802:
2800:
2798:(EC 2.7.11.7)
2797:
2793:
2787:
2784:
2783:
2781:
2779:(EC 2.7.11.6)
2778:
2774:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2749:
2747:
2745:(EC 2.7.11.5)
2744:
2740:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2718:
2716:(EC 2.7.11.4)
2715:
2711:
2703:
2700:
2698:
2695:
2693:
2690:
2689:
2687:
2683:
2680:
2678:
2675:
2674:
2672:
2668:
2665:
2663:
2660:
2659:
2657:
2654:
2653:
2651:
2649:(EC 2.7.11.3)
2648:
2644:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2619:
2617:
2615:(EC 2.7.11.2)
2614:
2610:
2602:
2599:
2598:
2597:
2594:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2571:
2570:
2569:EIF-2 kinases
2567:
2565:
2562:
2560:
2557:
2553:
2550:
2548:
2545:
2543:
2540:
2539:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2479:
2477:
2475:(EC 2.7.11.1)
2474:
2470:
2466:
2461:
2456:
2452:
2447:
2443:
2439:
2432:
2427:
2425:
2420:
2418:
2413:
2412:
2409:
2400:
2396:
2391:
2386:
2381:
2376:
2372:
2368:
2364:
2360:
2356:
2351:
2347:
2343:
2338:
2333:
2329:
2325:
2322:(8): 817–23.
2321:
2317:
2313:
2308:
2304:
2300:
2295:
2290:
2286:
2282:
2281:J. Biol. Chem
2278:
2273:
2269:
2265:
2260:
2255:
2252:(8): 1120–6.
2251:
2247:
2243:
2238:
2234:
2230:
2225:
2220:
2216:
2212:
2211:J. Biol. Chem
2208:
2203:
2199:
2195:
2191:
2187:
2184:(2): 554–61.
2183:
2179:
2174:
2170:
2166:
2161:
2156:
2152:
2148:
2144:
2139:
2135:
2131:
2127:
2123:
2120:(1): 111–28.
2119:
2115:
2110:
2106:
2102:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2067:
2063:
2059:
2054:
2049:
2045:
2041:
2040:J. Biol. Chem
2037:
2032:
2028:
2024:
2019:
2014:
2010:
2006:
2005:J. Biol. Chem
2002:
1997:
1993:
1989:
1984:
1979:
1975:
1971:
1967:
1963:
1959:
1954:
1950:
1946:
1941:
1936:
1932:
1928:
1924:
1920:
1916:
1911:
1907:
1903:
1899:
1895:
1892:(1): 133–40.
1891:
1887:
1882:
1878:
1874:
1869:
1864:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1829:
1825:
1821:
1816:
1811:
1807:
1803:
1799:
1795:
1791:
1786:
1785:
1772:
1768:
1763:
1758:
1754:
1750:
1746:
1742:
1738:
1731:
1723:
1719:
1714:
1709:
1705:
1701:
1697:
1693:
1689:
1682:
1674:
1670:
1666:
1662:
1659:(1): 111–28.
1658:
1654:
1647:
1645:
1643:
1641:
1639:
1637:
1628:
1624:
1619:
1614:
1610:
1606:
1602:
1595:
1587:
1583:
1579:
1575:
1571:
1567:
1560:
1558:
1549:
1543:
1541:
1532:
1528:
1523:
1518:
1514:
1510:
1506:
1502:
1498:
1491:
1483:
1479:
1474:
1469:
1464:
1459:
1455:
1451:
1447:
1443:
1439:
1432:
1424:
1420:
1414:
1406:
1402:
1396:
1389:
1385:
1380:
1378:
1376:
1368:
1364:
1359:
1357:
1355:
1350:
1341:
1338:
1337:
1333:
1332:
1323:
1320:
1317:
1314:
1311:
1308:
1305:
1302:
1299:
1296:
1293:
1290:
1289:
1288:
1286:
1276:
1273:
1269:
1265:
1260:
1258:
1254:
1250:
1240:
1238:
1234:
1233:proliferation
1229:
1220:
1217:
1213:
1209:
1205:
1202:in the yeast
1201:
1190:
1188:
1184:
1180:
1177:
1173:
1169:
1165:
1162:
1158:
1154:
1142:
1137:
1133:
1129:
1126:
1122:
1115:
1113:
1110:
1106:
1102:
1098:
1095:
1091:
1087:
1080:
1078:
1074:
1070:
1066:
1060:
1056:
1053:
1047:
1045:
1041:
1037:
1031:
1027:
1024:
1020:
1013:
1011:
1007:
1003:
999:
993:
989:
986:
980:
978:
974:
970:
964:
960:
957:
955:RefSeq (mRNA)
953:
946:
945:
940:
936:
933:
927:
926:
921:
917:
914:
912:
908:
901:
900:
895:
891:
888:
882:
881:
876:
872:
869:
867:
863:
856:
855:
850:
846:
843:
837:
836:
831:
827:
824:
822:
818:
815:
812:
810:
807:
803:
800:
796:
792:
785:
781:
776:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
709:cell division
707:
705:
702:
700:
697:
695:
692:
690:
687:
686:
684:
681:
680:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
650:
648:
645:
644:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
590:
589:Gene ontology
586:
582:
570:
565:
561:
556:
553:
551:
547:
539:
534:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
486:
483:
479:
474:
471:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
408:
405:
403:
399:
397:
396:
392:
391:
388:
386:
382:
378:
374:
370:
362:
357:
353:
349:
344:
334:
330:
323:
316:
310:
303:
295:
291:
287:
282:
278:
273:
269:
261:
256:
252:
248:
243:
233:
229:
222:
215:
209:
202:
198:
192:
188:
184:
179:
175:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
118:
113:
106:
101:
96:
85:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
4537:Translocases
4534:
4521:
4508:
4495:
4482:
4472:Transferases
4469:
4456:
4313:Binding site
4008:
3744:P70S6 kinase
2362:
2358:
2319:
2315:
2284:
2280:
2249:
2245:
2214:
2210:
2181:
2177:
2150:
2146:
2117:
2114:J. Mol. Biol
2113:
2078:
2074:
2043:
2039:
2008:
2004:
1965:
1961:
1922:
1918:
1889:
1885:
1840:
1836:
1797:
1793:
1744:
1740:
1730:
1695:
1691:
1681:
1656:
1653:J. Mol. Biol
1652:
1608:
1604:
1594:
1569:
1565:
1504:
1500:
1490:
1445:
1441:
1431:
1422:
1413:
1404:
1395:
1282:
1279:Interactions
1261:
1246:
1230:
1226:
1203:
1196:
1160:
1152:
1151:
1073:NP_001258497
1069:NP_001258496
1065:NP_001258495
1062:
1040:NP_001127892
1036:NP_001127891
1033:
1006:NM_001271568
1002:NM_001271567
998:NM_001271566
995:
973:NM_001134420
969:NM_001134419
966:
942:
923:
897:
878:
852:
833:
813:
808:
739:phagocytosis
520:vas deferens
516:spermatocyte
496:otic vesicle
488:otic placode
400:
393:
359:107,132,298
346:107,112,188
237:1p22.2-p22.1
120:External IDs
67:
4308:Active site
4195:(EC 2.7.12)
3582:Polo kinase
3522:Polo kinase
1243:Replication
1185:throughout
1176:chromosomal
1166:. The Cdc7
658:nucleoplasm
637:ATP binding
508:Paneth cell
338:5|5 E5
258:91,525,764
245:91,500,851
98:Identifiers
4580:Categories
4511:Isomerases
4485:Hydrolases
4352:Regulation
2873:IÎşB kinase
2448:2.7.11-12)
2246:Cell Cycle
2147:Cancer Res
1605:IUBMB Life
1566:Mutat. Res
1390:, May 2017
1369:, May 2017
1346:References
1334:Inhibitors
1187:eukaryotic
1172:cell cycle
749:cell cycle
404:(ortholog)
141:HomoloGene
4596:EC 2.7.11
4390:EC number
2999:PKC alpha
1183:conserved
1077:NP_033993
1044:NP_003494
1010:NM_009863
977:NM_003503
799:Orthologs
653:cytoplasm
149:GeneCards
4414:Kinetics
4338:Cofactor
4301:Activity
3355:KIAA0999
3250:MAPKAPK5
3245:MAPKAPK3
3240:MAPKAPK2
2399:16864800
2346:16826239
2316:EMBO Rep
2303:16446360
2268:16082200
2233:15668232
2198:15474462
2169:15466207
2134:12614612
2105:12065429
2062:11568184
2027:10846177
1992:10523313
1949:10373557
1771:10523313
1722:10373557
1673:12614612
1627:16036617
1586:14643427
1386:–
1365:–
1285:interact
1272:helicase
1193:Function
1125:Wikidata
778:Sources:
454:testicle
4570:Biology
4524:Ligases
4294:Enzymes
4014:MAP3K14
3992:MAP3K11
3987:MAP3K10
3977:MAP3K13
3972:MAP3K12
3774:RPS6KC1
3769:RPS6KA1
3764:RPS6KA3
3759:RPS6KA2
3754:RPS6KB2
3739:RPS6KA4
3734:RPS6KA5
3385:Kalirin
3350:SNF1LK2
2589:EIF2AK4
2584:EIF2AK3
2438:Kinases
2390:1544202
2367:Bibcode
2337:1525143
1983:1171637
1906:9573348
1877:9405610
1845:Bibcode
1824:9250678
1815:1170060
1762:1171637
1531:9250678
1522:1170060
1482:9405610
1450:Bibcode
1388:Ensembl
1367:Ensembl
1329:Ligands
1212:mitosis
911:UniProt
866:Ensembl
805:Species
784:QuickGO
668:nucleus
512:condyle
492:saccule
379:pattern
137:1309511
105:Aliases
4556:Portal
4498:Lyases
4244:MAP2K7
4239:MAP2K6
4234:MAP2K5
4229:MAP2K4
4224:MAP2K3
4219:MAP2K2
4214:MAP2K1
4165:ACVRL1
4160:ACVR2B
4155:ACVR2A
4150:ACVR1C
4145:ACVR1B
4128:BMPR1B
4123:BMPR1A
3997:MAP3K7
3982:MAP3K9
3933:MAP3K8
3928:MAP3K7
3923:MAP3K6
3918:MAP3K5
3913:MAP3K4
3908:MAP3K3
3903:MAP3K2
3898:MAP3K1
3872:MAPK14
3867:MAPK13
3862:MAPK11
3850:MAPK10
3828:MAPK15
3823:MAPK12
3715:CDC2L1
3690:CDC2L5
3365:SNF1LK
3190:CAMK2G
3185:CAMK2D
3180:CAMK2B
3175:CAMK2A
3165:CAMK1G
3160:CAMK1D
3155:CAMK1B
3150:CAMK1A
3004:PRKCB1
2941:PRKACA
2936:PRKACB
2931:PRKACG
2907:IKBKAP
2733:BCKDHB
2728:BCKDHA
2702:PRKAG3
2697:PRKAG2
2692:PRKAG1
2682:PRKAB2
2677:PRKAB1
2667:PRKAA2
2662:PRKAA1
2507:STK38L
2397:
2387:
2344:
2334:
2301:
2266:
2231:
2196:
2167:
2132:
2103:
2096:126049
2093:
2075:EMBO J
2060:
2025:
1990:
1980:
1962:EMBO J
1947:
1937:
1904:
1875:
1865:
1822:
1812:
1794:EMBO J
1769:
1759:
1741:EMBO J
1720:
1710:
1671:
1625:
1584:
1529:
1519:
1501:EMBO J
1480:
1470:
1340:XL-413
1287:with:
1168:kinase
1157:enzyme
1155:is an
1111:search
1109:PubMed
944:Q9Z0H0
925:O00311
821:Entrez
550:BioGPS
442:embryo
129:603311
4450:Types
4206:MAP2K
4140:ACVR1
4133:BMPR2
4118:BMPR1
4043:GSK-3
3884:MAP3K
3845:MAPK9
3840:MAPK8
3818:MAPK7
3813:MAPK6
3808:MAPK4
3803:MAPK3
3798:MAPK1
3710:PFTK1
3705:PCTK3
3700:PCTK2
3695:PCTK1
3685:CDK12
3680:CDK10
3655:CDKL5
3635:CDKL2
3512:STK19
3507:EEF2K
3488:PHKG2
3483:PHKG1
3473:PHKA2
3468:PHKA1
3449:MYLK4
3444:MYLK3
3439:MYLK2
3415:DCLK1
3410:Titin
3400:TRIB3
3395:TRIB2
3390:TRIB1
3380:TSSK2
3360:STK40
3345:PSKH1
3340:PRKD3
3335:PRKD2
3315:PHKG2
3310:PHKG1
3300:OBSCN
3295:NUAK2
3290:NUAK1
3285:MKNK2
3280:MKNK1
3270:MARK4
3265:MARK3
3260:MARK2
3255:MARK1
3235:STK11
3230:DAPK3
3225:DAPK2
3220:DAPK1
3215:CHEK2
3210:CHEK1
3195:CAMK4
3170:CAMK2
3145:CAMK1
3140:BRSK2
3034:PRKCQ
3029:PRKCI
3024:PRKCG
3019:PRKCH
3014:PRKCE
3009:PRKCD
2970:PRKG1
2902:IKBKG
2897:IKBKE
2846:STK10
2841:FASTK
2767:IDH3G
2762:IDH3B
2757:IDH3A
2723:BCKDK
2517:ROCK1
2502:STK38
2497:MAST2
2492:MAST1
2487:LATS2
2482:LATS1
1940:84351
1868:24960
1713:84351
1473:24960
1322:ORC6L
1318:, and
1316:ORC1L
854:12545
814:Mouse
809:Human
780:Amigo
524:fossa
434:gonad
402:Mouse
395:Human
342:Start
277:Mouse
241:Start
174:Human
145:31166
4542:list
4535:EC7
4529:list
4522:EC6
4516:list
4509:EC5
4503:list
4496:EC4
4490:list
4483:EC3
4477:list
4470:EC2
4464:list
4457:EC1
4033:TPK1
4009:CDC7
3967:MLKs
3960:KSR2
3955:KSR1
3950:BRAF
3945:ARAF
3940:RAFs
3675:CDK9
3670:CDK8
3665:CDK7
3660:CDK6
3650:CDK5
3645:CDK4
3640:CDK3
3630:CDK2
3625:CDK1
3606:PLK4
3601:PLK3
3596:PLK2
3591:PLK1
3546:PLK4
3541:PLK3
3536:PLK2
3531:PLK1
3478:PHKB
3434:MYLK
3405:TRIO
3375:SPEG
3370:SNRK
3330:PKD1
3325:PIM2
3320:PIM1
3305:PASK
3275:MELK
3205:CASK
3200:MLCK
3121:GRK6
3116:GRK5
3111:GRK4
3049:PKN3
3044:PKN2
2946:PRKY
2892:TBK1
2887:IKK2
2882:CHUK
2786:STK4
2752:IDH2
2637:PDK4
2632:PDK3
2627:PDK2
2622:PDK1
2601:WEE1
2596:Wee1
2564:mTOR
2552:AKT3
2547:AKT2
2542:AKT1
2532:SGK3
2527:SGK2
2395:PMID
2342:PMID
2299:PMID
2264:PMID
2229:PMID
2194:PMID
2165:PMID
2130:PMID
2101:PMID
2058:PMID
2023:PMID
1988:PMID
1945:PMID
1902:PMID
1886:Gene
1873:PMID
1820:PMID
1767:PMID
1718:PMID
1669:PMID
1623:PMID
1582:PMID
1527:PMID
1478:PMID
1310:MCM7
1304:MCM4
1298:MCM5
1292:DBF4
1257:Cdt1
1255:and
1253:Cdc6
1200:Dbf4
1164:gene
1161:CDC7
835:8317
385:Bgee
333:Band
294:Chr.
232:Band
191:Chr.
153:CDC7
125:OMIM
112:CDC7
82:4F9C
78:4F9B
74:4F9A
70:4F99
51:RCSB
48:PDBe
22:CDC7
4038:TTK
4002:ZAK
2579:HRI
2574:PKR
2522:SGK
2512:CIT
2385:PMC
2375:doi
2363:103
2332:PMC
2324:doi
2289:doi
2285:281
2254:doi
2219:doi
2215:280
2186:doi
2182:324
2155:doi
2122:doi
2118:327
2091:PMC
2083:doi
2048:doi
2044:276
2013:doi
2009:275
1978:PMC
1970:doi
1935:PMC
1927:doi
1894:doi
1890:211
1863:PMC
1853:doi
1810:PMC
1802:doi
1757:PMC
1749:doi
1708:PMC
1700:doi
1661:doi
1657:327
1613:doi
1574:doi
1570:532
1517:PMC
1509:doi
1468:PMC
1458:doi
1237:p53
355:End
254:End
157:OMA
133:MGI
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