317:
294:
216:
191:
582:
575:
568:
323:
222:
1427:
Recently, CD46 has emerged as a promising target for the treatment of both adenocarcinoma and neuroendocrine types of metastatic castration-resistant prostate cancer (mCRPC). YS5, a human full-length IgG1 with high specificity for CD46, was identified to have high binding affinity for prostate cancer
1402:
domain surrounded by flexible loops. As has been demonstrated for CD46 with other ligands, the CD46 protein structure is believed to linearize upon binding HHV-6. While their precise interaction has not yet been determined, the second and third SCR domains have been demonstrated to be required for
2265:
50:
1415:(a malignant brain tumor common in childhood) specimens express CD46, and that medulloblastoma specimens removed from patients had a high level of CD46 expression. Therefore, a vaccine made of the Edmonston strain of measles virus could treat the medulloblastoma.
1428:
tissue. YS5 has been developed into an antibody-drug conjugate, FOR46, which is currently in a phase I clinical trial (NCT03575819) for the treatment of mCRPC. Since then, a companion molecular imaging agent for CD46-targeted therapy has been developed.
1998:
Su, Yang; Liu, Yue; Behrens, Christopher R.; Bidlingmaier, Scott; Lee, Nam-Kyung; Aggarwal, Rahul; Sherbenou, Daniel W.; Burlingame, Alma L.; Hann, Byron C.; Simko, Jeffry P.; Premasekharan, Gayatri (2018-09-06).
330:
229:
1332:
32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.
1559:
Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)".
2105:
Wang, Sinan; Li, Jun; Hua, Jun; Su, Yang; Beckford-Vera, Denis R.; Zhao, Walter; Jayaraman, Mayuri; Huynh, Tony L.; Zhao, Ning; Wang, Yung-hua; Huang, Yangjie (2021-03-01).
3203:
2342:
1594:
Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster".
1419:
has already been tested in a number of trials involving other tumor types which have a high expression of CD46, including one type of adult brain tumor.
2058:"Identification of Clinically Significant Tumor Antigens by Selecting Phage Antibody Library on Tumor Cells in Situ Using Laser Capture Microdissection"
935:
916:
152:
3193:
2320:
1541:
1523:
4379:
47:
3173:
1231:
1238:
4035:
2359:
2335:
2281:
1403:
HHV-6 receptor binding and cellular entry. The heterotetramer gH/gL/gQ1/gQ2 complex of HHV-6 has been identified as a CD46 ligand.
3766:
1629:
1643:
Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (September 2004). "CD46: expanding beyond complement regulation".
3754:
3532:
2234:
2217:
1398:
The extracellular region of CD46 contains four short consensus repeats (SCR) of about 60 amino acids that fold into a compact
3818:
3813:
3759:
3539:
1506:
4799:
4794:
3272:
3198:
2328:
2287:
4301:
4296:
4291:
4286:
3213:
1485:
4593:
4266:
316:
3502:
4372:
4070:
3564:
3250:
1510:
1489:
293:
4412:
3709:
3245:
980:
2350:
4206:
3678:
3673:
3618:
3352:
2801:
961:
4402:
3900:
3623:
1721:
Dörig RE, Marcil A, Richardson CD (September 1994). "CD46, a primate-specific receptor for measles virus".
1678:
Liszewski MK, Kemper C, Price JD, Atkinson JP (November 2005). "Emerging roles and new functions of CD46".
215:
190:
132:
3218:
1449:
4365:
3930:
2355:
1347:
The encoded protein has cofactor activity for inactivation (through cleavage) of complement components
1298:
329:
228:
4648:
2796:
1801:"Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet"
1756:
Gaggar A, Shayakhmetov, DM, Lieber A (2003). "CD46 is a cellular receptor for group B adenoviruses".
322:
221:
119:
3980:
2875:
2274:
140:
4728:
4598:
4563:
4558:
4453:
4448:
4443:
3944:
2216:
Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000).
1214:
1193:
1189:
1185:
1181:
1177:
1173:
1169:
1159:
1155:
1151:
1147:
1143:
1123:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1060:
1056:
1052:
1048:
1044:
4618:
4608:
4603:
4553:
4532:
4477:
4460:
3287:
3282:
3277:
3267:
2574:
2502:
1340:
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the
4700:
4695:
4496:
2631:
2549:
4710:
4705:
3868:
3581:
204:
2218:"CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans"
1572:
160:
8:
4687:
4667:
4657:
4506:
3895:
3714:
2293:
1385:
1317:
2270:
1607:
3302:
3036:
2188:
2163:
2139:
2106:
2033:
1972:
1947:
1928:
1874:
1849:
1781:
1703:
164:
1825:
1800:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
653:
648:
643:
638:
633:
628:
623:
4388:
2309:
2300:
2239:
2193:
2144:
2126:
2087:
2079:
2038:
2020:
1977:
1920:
1915:
1898:
1879:
1830:
1773:
1738:
1734:
1695:
1660:
1611:
1576:
1437:
1341:
112:
40:
1946:
Studebaker AW, Kreofsky CR, Pierson CR, Russell SJ, Galanis E, Raffel C (May 2010).
1932:
1816:
1785:
1707:
144:
4762:
4715:
4537:
4075:
3808:
3729:
3292:
2485:
2411:
2229:
2183:
2175:
2164:"Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections"
2134:
2118:
2069:
2028:
2012:
1967:
1959:
1910:
1869:
1861:
1820:
1812:
1765:
1730:
1687:
1652:
1603:
1568:
409:
340:
284:
239:
2122:
2056:
Ruan, Weiming; Sassoon, Adam; An, Feng; Simko, Jeff P.; Liu, Bin (December 2006).
4491:
4487:
4135:
2671:
2666:
2589:
1865:
1412:
384:
168:
1546:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1528:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4407:
3920:
3342:
2853:
2656:
2074:
2057:
2016:
2000:
1850:"The molecular biology of human herpesvirus-6 latency and telomere integration"
485:
2260:
2179:
1691:
4788:
4577:
4572:
3890:
3347:
2438:
2130:
2083:
2024:
1656:
1380:
610:
581:
574:
567:
1963:
545:
423:
4773:
4768:
4756:
4738:
4733:
4643:
4246:
3554:
3544:
3075:
3041:
2243:
2197:
2148:
2091:
2042:
2001:"Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer"
1981:
1924:
1883:
1834:
1777:
1699:
1664:
1355:
by serum factor I, which protects the host cell from damage by complement.
1329:
402:
181:
1742:
1615:
1580:
1278:
1273:
4256:
3905:
3683:
3658:
3357:
2979:
2905:
2379:
1399:
1359:
1025:
1006:
4613:
4438:
4186:
3910:
3591:
3332:
3208:
2841:
2836:
2831:
2686:
2470:
301:
198:
148:
1379:
The encoded protein can act as a receptor for the
Edmonston strain of
1358:
The protein encoded by this gene may be involved in the fusion of the
89:
85:
81:
77:
73:
69:
4516:
4025:
4020:
4015:
4005:
4000:
3995:
3990:
2235:
10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X
2107:"Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET"
1391:
880:
368:
355:
267:
254:
156:
4357:
4677:
4511:
4331:
4231:
4045:
4030:
3233:
3228:
3136:
2826:
2261:
GeneReviews/NCBI/NIH/UW entry on
Atypical Hemolytic-Uremic Syndrome
1262:
1769:
4281:
4276:
4271:
4171:
3985:
3975:
3802:
3781:
3776:
3744:
3549:
3469:
3464:
3459:
3454:
3449:
3367:
3060:
2900:
2895:
2890:
2885:
2880:
2351:
2314:
2304:
1306:
992:
947:
865:
861:
806:
positive regulation of transforming growth factor beta production
1945:
1630:"Entrez Gene: CD46 CD46 molecule, complement regulatory protein"
136:
4221:
4181:
4166:
4150:
4145:
4125:
4120:
4055:
3863:
3833:
3797:
3788:
3601:
3569:
3433:
3428:
3398:
3377:
3337:
3297:
3163:
3141:
3100:
3024:
3019:
3014:
3009:
3004:
2999:
2868:
2863:
2858:
2806:
2791:
2661:
2651:
2614:
2609:
2527:
2522:
2215:
1642:
1416:
1363:
1246:
902:
590:
1389:(HHV-6), group B adenoviruses, and type IV pili of pathogenic
4719:
4346:
4321:
4241:
4236:
4226:
4216:
4201:
4196:
4191:
4176:
4130:
4115:
4080:
4065:
4060:
4050:
3970:
3965:
3960:
3939:
3935:
3925:
3838:
3739:
3734:
3693:
3643:
3638:
3633:
3628:
3613:
3606:
3586:
3574:
3517:
3512:
3507:
3497:
3492:
3485:
3423:
3413:
3408:
3403:
3393:
3372:
3362:
3327:
3322:
3317:
3312:
3307:
3262:
3257:
3223:
3188:
3183:
3178:
3168:
3156:
3151:
3131:
3126:
3121:
3116:
3070:
2962:
2957:
2776:
2760:
2753:
2748:
2743:
2738:
2733:
2728:
2703:
2681:
2676:
2569:
2495:
2490:
2480:
1457:
2299:
Overview of all the structural information available in the
1948:"Treatment of medulloblastoma with a modified measles virus"
1677:
1558:
4723:
4652:
4546:
4341:
4336:
4326:
4316:
4311:
4306:
4261:
4251:
4211:
4140:
4110:
4105:
4100:
4095:
4090:
4085:
4040:
4010:
3915:
3883:
3878:
3858:
3848:
3843:
3828:
3823:
3724:
3719:
3688:
3668:
3663:
3653:
3648:
3527:
3480:
3440:
3095:
3090:
3085:
3080:
3065:
3056:
3051:
3046:
3031:
2989:
2984:
2974:
2969:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2848:
2821:
2816:
2811:
2786:
2781:
2718:
2713:
2698:
2693:
2646:
2641:
2636:
2626:
2621:
2604:
2599:
2594:
2584:
2579:
2564:
2559:
2554:
2544:
2539:
2534:
2517:
2512:
2507:
2458:
2426:
2421:
2416:
2399:
2394:
2389:
2384:
1899:"Recent topics related to human herpesvirus 6 cell tropism"
1461:
1313:
1755:
4542:
4470:
4465:
3853:
2465:
2453:
2448:
2443:
2433:
2406:
2374:
2161:
1453:
1352:
1348:
1997:
771:
positive regulation of regulatory T cell differentiation
392:
1720:
1593:
557:
796:
positive regulation of memory T cell differentiation
2266:OMIM entries on Atypical Hemolytic-Uremic Syndrome
2055:
1502:
1500:
1498:
1481:
1479:
1477:
766:sequestering of extracellular ligand from receptor
339:
238:
4786:
2313:(Human Membrane cofactor protein (CD46)) at the
756:positive regulation of interleukin-10 production
123:, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
2211:
2209:
2207:
1495:
1474:
1507:GRCm38: Ensembl release 89: ENSMUSG00000016493
4373:
2336:
2204:
2155:
1939:
1792:
851:negative regulation of complement activation
2104:
1714:
1671:
1636:
1486:GRCh38: Ensembl release 89: ENSG00000117335
791:positive regulation of T cell proliferation
4380:
4366:
2343:
2329:
1798:
1587:
1552:
2360:list of human clusters of differentiation
2273:at the U.S. National Library of Medicine
2233:
2187:
2138:
2073:
2032:
1971:
1914:
1873:
1824:
846:negative regulation of catalytic activity
1847:
1431:
1369:
801:complement activation, classical pathway
16:Mammalian protein found in Homo sapiens
4787:
786:positive regulation of gene expression
776:negative regulation of gene expression
4387:
4361:
2324:
1993:
1991:
1573:10.1093/oxfordjournals.humrep.a138615
821:regulation of Notch signaling pathway
695:integral component of plasma membrane
344:
305:
300:
243:
202:
197:
1896:
1374:
2062:Molecular & Cellular Proteomics
1608:10.1146/annurev.iy.09.040191.002243
1328:This gene is found in a cluster on
826:regulation of complement activation
13:
2162:Liszewski MK, Atkinson JP (2021).
1988:
1422:
1406:
1309:which in humans is encoded by the
1291:CD46 complement regulatory protein
14:
4811:
2254:
1916:10.1111/j.1462-5822.2009.01312.x
580:
573:
566:
520:lumbar subsegment of spinal cord
328:
321:
315:
292:
227:
220:
214:
189:
2098:
2049:
1890:
1841:
1817:10.1128/JVI.78.9.4385-4388.2004
1749:
1443:
1436:CD46 deficiency contributes to
1622:
1534:
1516:
670:integral component of membrane
591:More reference expression data
546:More reference expression data
1:
2123:10.1158/1078-0432.CCR-20-3310
1467:
313:
212:
1866:10.1016/j.micinf.2011.03.006
1735:10.1016/0966-842X(94)90447-2
1680:Springer Semin. Immunopathol
7:
4800:Clusters of differentiation
4795:Genes on human chromosome 1
2356:clusters of differentiation
1335:
730:basolateral plasma membrane
654:signaling receptor activity
10:
4816:
2292:gene details page in the
2075:10.1074/mcp.m600246-mcp200
2017:10.1172/jci.insight.121497
1299:cluster of differentiation
811:viral entry into host cell
4749:
4686:
4649:Decay-accelerating factor
4633:
4586:
4525:
4428:
4421:
4395:
4159:
3953:
3702:
3386:
3109:
2769:
2367:
2180:10.1016/j.coi.2021.04.005
1692:10.1007/s00281-005-0002-3
1542:"Mouse PubMed Reference:"
1524:"Human PubMed Reference:"
1303:Membrane Cofactor Protein
1277:
1272:
1268:
1261:
1245:
1239:Chr 1: 194.72 – 194.77 Mb
1226:
1211:
1207:
1166:
1142:
1135:
1120:
1116:
1067:
1043:
1036:
1023:
1019:
1004:
1000:
991:
978:
974:
959:
955:
946:
933:
929:
914:
910:
901:
886:
879:
875:
859:
831:interleukin-10 production
649:enzyme inhibitor activity
609:
605:
588:
565:
556:
543:
492:
483:
442:bronchial epithelial cell
430:
421:
391:
383:
379:
362:
349:
312:
291:
282:
278:
261:
248:
211:
188:
179:
175:
130:
127:
117:
110:
105:
66:
61:
44:
39:
34:
30:
26:
21:
2275:Medical Subject Headings
2111:Clinical Cancer Research
1848:Arbuckle, Jesse (2011).
1657:10.1016/j.it.2004.07.004
1316:. CD46 is an inhibitory
1232:Chr 1: 207.75 – 207.8 Mb
751:adaptive immune response
746:T cell mediated immunity
675:inner acrosomal membrane
1799:Cattaneo R (May 2004).
1448:CD46 has been shown to
1323:
624:virus receptor activity
508:vastus lateralis muscle
1854:Microbes and Infection
1438:inflammation disorders
1366:during fertilization.
836:innate immune response
644:endopeptidase activity
1964:10.1093/neuonc/noq057
1903:Cellular Microbiology
1432:Inflammatory diseases
1370:Clinical significance
761:immune system process
705:extracellular exosome
516:primary visual cortex
434:palpebral conjunctiva
4688:Complement receptors
2286:genome location and
781:single fertilization
346:1 H6|1 98.41 cM
307:Chromosome 1 (mouse)
205:Chromosome 1 (human)
62:List of PDB id codes
35:Available structures
2294:UCSC Genome Browser
1386:human herpesvirus-6
1318:complement receptor
710:cytoplasmic vesicle
496:seminiferous tubule
450:germinal epithelium
4517:Factor P/Properdin
4422:Activators/enzymes
1596:Annu. Rev. Immunol
981:ENSMUSG00000016493
739:Biological process
663:Cellular component
639:complement binding
617:Molecular function
462:right uterine tube
4782:
4781:
4629:
4628:
4389:Complement system
4355:
4354:
2168:Curr Opin Immunol
2068:(12): 2364–2373.
1958:(10): 1034–1042.
1764:(11): 1408–1412.
1375:Measles infection
1342:complement system
1288:
1287:
1284:
1283:
1257:
1256:
1222:
1221:
1201:
1200:
1131:
1130:
1110:
1109:
1032:
1031:
1013:
1012:
987:
986:
968:
967:
942:
941:
923:
922:
871:
870:
715:acrosomal vesicle
601:
600:
597:
596:
552:
551:
539:
538:
512:intestinal villus
477:
476:
375:
374:
274:
273:
101:
100:
97:
96:
45:Ortholog search:
4807:
4763:immune adherence
4426:
4425:
4382:
4375:
4368:
4359:
4358:
2345:
2338:
2331:
2322:
2321:
2248:
2247:
2237:
2213:
2202:
2201:
2191:
2159:
2153:
2152:
2142:
2117:(5): 1305–1315.
2102:
2096:
2095:
2077:
2053:
2047:
2046:
2036:
1995:
1986:
1985:
1975:
1943:
1937:
1936:
1918:
1894:
1888:
1887:
1877:
1860:(8–9): 731–741.
1845:
1839:
1838:
1828:
1796:
1790:
1789:
1753:
1747:
1746:
1723:Trends Microbiol
1718:
1712:
1711:
1675:
1669:
1668:
1640:
1634:
1633:
1626:
1620:
1619:
1591:
1585:
1584:
1556:
1550:
1549:
1538:
1532:
1531:
1520:
1514:
1504:
1493:
1483:
1270:
1269:
1241:
1234:
1217:
1205:
1204:
1196:
1140:
1139:
1136:RefSeq (protein)
1126:
1114:
1113:
1105:
1041:
1040:
1017:
1016:
998:
997:
972:
971:
953:
952:
927:
926:
908:
907:
877:
876:
629:cadherin binding
607:
606:
593:
584:
577:
570:
563:
562:
548:
528:ventricular zone
488:
486:Top expressed in
481:
480:
470:body of pancreas
438:seminal vesicula
426:
424:Top expressed in
419:
418:
398:
397:
381:
380:
371:
358:
347:
332:
325:
319:
308:
296:
280:
279:
270:
257:
246:
231:
224:
218:
207:
193:
177:
176:
171:
169:CD46 - orthologs
122:
115:
92:
59:
58:
53:
32:
31:
19:
18:
4815:
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4810:
4809:
4808:
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4784:
4783:
4778:
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4682:
4625:
4582:
4521:
4417:
4391:
4386:
4356:
4351:
4155:
3949:
3698:
3382:
3105:
2765:
2363:
2349:
2257:
2252:
2251:
2222:Eur. J. Immunol
2214:
2205:
2160:
2156:
2103:
2099:
2054:
2050:
1996:
1989:
1944:
1940:
1895:
1891:
1846:
1842:
1797:
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1522:
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1517:
1505:
1496:
1484:
1475:
1470:
1446:
1434:
1425:
1423:Prostate cancer
1413:medulloblastoma
1409:
1407:Medulloblastoma
1377:
1372:
1338:
1326:
1279:View/Edit Mouse
1274:View/Edit Human
1237:
1230:
1227:Location (UCSC)
1213:
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1188:
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1180:
1176:
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1077:
1073:
1069:
1063:
1059:
1055:
1051:
1047:
962:ENSG00000117335
855:
734:
725:Golgi apparatus
690:plasma membrane
658:
634:protein binding
589:
579:
578:
572:
571:
544:
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524:muscle of thigh
522:
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283:Gene location (
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180:Gene location (
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68:
46:
17:
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2256:
2255:External links
2253:
2250:
2249:
2203:
2154:
2097:
2048:
1987:
1938:
1889:
1840:
1791:
1748:
1713:
1670:
1651:(9): 496–503.
1645:Trends Immunol
1635:
1621:
1586:
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1533:
1515:
1494:
1472:
1471:
1469:
1466:
1445:
1442:
1433:
1430:
1424:
1421:
1417:Such a vaccine
1408:
1405:
1376:
1373:
1371:
1368:
1337:
1334:
1325:
1322:
1293:also known as
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717:
712:
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697:
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687:
685:focal adhesion
682:
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664:
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455:
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447:
446:jejunal mucosa
443:
439:
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431:
428:
427:
415:
414:
406:
395:
389:
388:
385:RNA expression
377:
376:
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372:
364:
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359:
351:
348:
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55:
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15:
9:
6:
4:
3:
2:
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4761:
4758:
4755:
4754:
4752:
4748:
4740:
4737:
4735:
4732:
4731:
4730:
4729:Anaphylatoxin
4727:
4725:
4721:
4717:
4714:
4712:
4709:
4707:
4704:
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4699:
4697:
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4605:
4602:
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4597:
4596:
4595:
4592:
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4589:
4585:
4579:
4578:C5-convertase
4576:
4574:
4573:C3-convertase
4571:
4570:
4565:
4562:
4560:
4557:
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4555:
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3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3158:
3155:
3153:
3150:
3149:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3114:
3112:
3108:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2997:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2964:
2961:
2959:
2956:
2955:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2878:
2877:
2874:
2870:
2867:
2865:
2862:
2860:
2857:
2856:
2855:
2852:
2850:
2847:
2843:
2840:
2838:
2835:
2833:
2830:
2829:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2774:
2772:
2768:
2762:
2759:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2726:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2669:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2616:
2613:
2611:
2608:
2607:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2529:
2526:
2524:
2521:
2520:
2519:
2516:
2514:
2511:
2509:
2506:
2504:
2501:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2478:
2477:
2474:
2472:
2469:
2467:
2464:
2460:
2457:
2456:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2428:
2425:
2423:
2420:
2418:
2415:
2414:
2413:
2410:
2408:
2405:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2377:
2376:
2373:
2372:
2370:
2366:
2361:
2357:
2353:
2346:
2341:
2339:
2334:
2332:
2327:
2326:
2323:
2316:
2312:
2311:
2306:
2302:
2298:
2295:
2291:
2290:
2285:
2284:
2279:
2276:
2272:
2269:
2267:
2264:
2262:
2259:
2258:
2245:
2241:
2236:
2231:
2227:
2223:
2219:
2212:
2210:
2208:
2199:
2195:
2190:
2185:
2181:
2177:
2173:
2169:
2165:
2158:
2150:
2146:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2101:
2093:
2089:
2085:
2081:
2076:
2071:
2067:
2063:
2059:
2052:
2044:
2040:
2035:
2030:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1994:
1992:
1983:
1979:
1974:
1969:
1965:
1961:
1957:
1953:
1949:
1942:
1934:
1930:
1926:
1922:
1917:
1912:
1909:(7): 1001–6.
1908:
1904:
1900:
1897:Mori (2009).
1893:
1885:
1881:
1876:
1871:
1867:
1863:
1859:
1855:
1851:
1844:
1836:
1832:
1827:
1822:
1818:
1814:
1811:(9): 4385–8.
1810:
1806:
1802:
1795:
1787:
1783:
1779:
1775:
1771:
1770:10.1038/nm952
1767:
1763:
1759:
1752:
1744:
1740:
1736:
1732:
1728:
1724:
1717:
1709:
1705:
1701:
1697:
1693:
1689:
1686:(3): 345–58.
1685:
1681:
1674:
1666:
1662:
1658:
1654:
1650:
1646:
1639:
1631:
1625:
1617:
1613:
1609:
1605:
1602:(1): 431–55.
1601:
1597:
1590:
1582:
1578:
1574:
1570:
1567:(5): 907–11.
1566:
1562:
1555:
1547:
1543:
1537:
1529:
1525:
1519:
1512:
1508:
1503:
1501:
1499:
1491:
1487:
1482:
1480:
1478:
1473:
1465:
1463:
1459:
1455:
1451:
1441:
1439:
1429:
1420:
1418:
1414:
1404:
1401:
1396:
1394:
1393:
1388:
1387:
1382:
1381:measles virus
1367:
1365:
1361:
1356:
1354:
1350:
1345:
1343:
1333:
1331:
1330:chromosome 1q
1321:
1319:
1315:
1312:
1308:
1304:
1300:
1296:
1292:
1280:
1275:
1271:
1267:
1264:
1260:
1253:
1251:
1248:
1244:
1240:
1236:
1233:
1229:
1225:
1218:
1216:
1210:
1206:
1203:
1197:
1195:
1191:
1187:
1183:
1179:
1175:
1171:
1165:
1161:
1157:
1153:
1149:
1145:
1141:
1138:
1134:
1127:
1125:
1119:
1115:
1112:
1106:
1104:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1039:
1037:RefSeq (mRNA)
1035:
1028:
1027:
1022:
1018:
1015:
1009:
1008:
1003:
999:
996:
994:
990:
983:
982:
977:
973:
970:
964:
963:
958:
954:
951:
949:
945:
938:
937:
932:
928:
925:
919:
918:
913:
909:
906:
904:
900:
897:
894:
892:
889:
885:
882:
878:
874:
867:
863:
858:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
816:viral process
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
743:
741:
738:
737:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
667:
665:
662:
661:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
612:
611:Gene ontology
608:
604:
592:
587:
583:
576:
569:
564:
561:
559:
555:
547:
542:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
494:
491:
487:
482:
479:
469:
465:
461:
457:
454:parotid gland
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
416:
413:
411:
407:
405:
404:
400:
399:
396:
394:
390:
386:
382:
378:
370:
365:
361:
357:
352:
342:
338:
331:
324:
318:
311:
303:
299:
295:
290:
286:
281:
277:
269:
264:
260:
256:
251:
241:
237:
230:
223:
217:
210:
206:
200:
196:
192:
187:
183:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
126:
121:
114:
109:
104:
93:
91:
87:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
4774:Opsonization
4769:inflammation
4757:Cytotoxicity
4674:
4664:
4644:C1-inhibitor
4640:
4503:
4484:
4435:
3873:
3793:
3771:
3749:
3596:
3559:
3522:
3475:
3445:
3418:
3240:
3146:
2994:
2723:
2708:
2475:
2308:
2288:
2282:
2271:CD46+antigen
2228:(3): 900–7.
2225:
2221:
2171:
2167:
2157:
2114:
2110:
2100:
2065:
2061:
2051:
2008:
2004:
1955:
1951:
1941:
1906:
1902:
1892:
1857:
1853:
1843:
1808:
1804:
1794:
1761:
1757:
1751:
1729:(9): 312–8.
1726:
1722:
1716:
1683:
1679:
1673:
1648:
1644:
1638:
1624:
1599:
1595:
1589:
1564:
1560:
1554:
1545:
1536:
1527:
1518:
1447:
1444:Interactions
1435:
1426:
1411:Established
1410:
1397:
1390:
1384:
1378:
1357:
1346:
1339:
1327:
1310:
1302:
1294:
1290:
1289:
1212:
1167:
1121:
1068:
1024:
1005:
979:
960:
934:
915:
895:
890:
700:cell surface
408:
401:
367:194,774,557
354:194,719,134
266:207,795,513
253:207,752,037
128:External IDs
67:
2174:: 126–134.
2005:JCI Insight
1952:Neuro Oncol
1561:Hum. Reprod
1400:beta-barrel
1360:spermatozoa
841:proteolysis
504:granulocyte
106:Identifiers
4789:Categories
4634:Inhibitors
2358:(see also
1513:, May 2017
1492:, May 2017
1468:References
466:right lung
412:(ortholog)
149:HomoloGene
4767:Inducing
2131:1078-0432
2084:1535-9476
2025:0021-9738
1392:Neisseria
1362:with the
1215:NP_034908
1194:NP_758868
1190:NP_758867
1186:NP_758866
1182:NP_758865
1178:NP_758871
1174:NP_758869
1170:NP_758863
1160:NP_758862
1156:NP_758861
1152:NP_758860
1148:NP_722548
1144:NP_002380
1124:NM_010778
1103:NM_172361
1099:NM_172360
1095:NM_172359
1091:NM_172358
1087:NM_172357
1083:NM_172356
1079:NM_172355
1075:NM_172354
1071:NM_172353
1061:NM_172352
1057:NM_172351
1053:NM_172350
1049:NM_153826
1045:NM_002389
881:Orthologs
720:cytoplasm
500:spermatid
157:GeneCards
4759:(by MAC)
4750:Function
4678:Factor H
4658:Factor I
4512:Factor D
4507:Factor B
4396:Pathways
2352:Proteins
2244:10741407
2198:34004375
2149:33293372
2092:16982673
2043:30185663
1982:20494960
1933:20827342
1925:19290911
1884:21458587
1835:15078919
1805:J. Virol
1786:25265753
1778:14566335
1758:Nat. Med
1708:28240864
1700:16200405
1665:15324743
1509:–
1488:–
1450:interact
1336:Function
1301:46) and
1263:Wikidata
860:Sources:
680:membrane
458:placenta
4160:301–350
3954:251–300
3906:CD240CE
3703:201–250
3387:151–200
3110:101–150
2315:PDBe-KB
2305:UniProt
2189:8123722
2140:7925362
2034:6171802
1973:3018921
1875:3130849
1743:7529121
1616:1910685
1581:7929741
1511:Ensembl
1490:Ensembl
1307:protein
993:UniProt
948:Ensembl
887:Species
866:QuickGO
387:pattern
145:1203290
113:Aliases
4526:Middle
4167:CD300A
4126:CDw293
3911:CD240D
3772:CD213a
3750:CDw210
3715:CD202b
3689:CDw199
3684:CDw198
3338:CD140b
2770:51–100
2310:P15529
2280:Human
2277:(MeSH)
2242:
2196:
2186:
2147:
2137:
2129:
2090:
2082:
2041:
2031:
2023:
2011:(17).
1980:
1970:
1931:
1923:
1882:
1872:
1833:
1826:387720
1823:
1784:
1776:
1741:
1706:
1698:
1663:
1614:
1579:
1364:oocyte
1249:search
1247:PubMed
1026:O88174
1007:P15529
903:Entrez
558:BioGPS
532:embryo
245:1q32.2
137:120920
4720:CD11c
4716:CD11b
4492:MASP2
4488:MASP1
4429:Early
4347:CD350
4342:CD349
4337:CD344
4332:CD340
4327:CD339
4322:CD338
4317:CD337
4312:CD336
4307:CD335
4302:CD334
4297:CD333
4292:CD332
4287:CD331
4282:CD329
4277:CD328
4272:CD327
4267:CD326
4262:CD325
4257:CD324
4252:CD322
4247:CD321
4242:CD320
4237:CD318
4232:CD317
4227:CD316
4222:CD315
4217:CD314
4212:CD312
4207:CD309
4202:CD307
4197:CD306
4192:CD305
4187:CD304
4182:CD303
4177:CD302
4172:CD301
4151:CD299
4146:CD298
4141:CD297
4136:CD295
4131:CD294
4121:CD292
4116:CD290
4111:CD289
4106:CD288
4101:CD286
4096:CD284
4091:CD283
4086:CD282
4081:CD281
4076:CD280
4071:CD279
4066:CD278
4061:CD276
4056:CD275
4051:CD274
4046:CD273
4041:CD272
4036:CD271
4031:CD269
4026:CD268
4021:CD267
4016:CD266
4011:CD265
4006:CD264
4001:CD263
3996:CD262
3991:CD261
3986:CD258
3981:CD257
3976:CD256
3971:CD254
3966:CD253
3961:CD252
3945:CD249
3940:CD248
3936:CD247
3931:CD246
3926:CD244
3921:CD243
3916:CD241
3901:CD239
3896:CD238
3891:CD236
3874:CD235
3869:CD234
3864:CD233
3859:CD230
3854:CD229
3849:CD228
3844:CD227
3839:CD226
3834:CD225
3829:CD224
3824:CD223
3819:CD222
3814:CD221
3809:CD220
3794:CD218
3789:CD217
3767:CD212
3745:CD209
3740:CD208
3735:CD207
3730:CD206
3725:CD205
3720:CD204
3710:CD201
3694:CD200
3679:CD197
3674:CD196
3669:CD195
3664:CD194
3659:CD193
3654:CD192
3649:CD191
3644:CD186
3639:CD185
3634:CD184
3629:CD183
3624:CD182
3619:CD181
3614:CD180
3597:CD179
3592:CD178
3587:CD177
3582:CD174
3560:CD172
3555:CD171
3550:CD170
3545:CD169
3540:CD168
3523:CD167
3518:CD166
3513:CD164
3508:CD163
3503:CD162
3498:CD161
3493:CD160
3476:CD159
3446:CD158
3441:CD157
3419:CD156
3414:CD155
3409:CD154
3404:CD153
3399:CD152
3394:CD151
3378:CD150
3373:CD148
3368:CD147
3363:CD146
3358:CD144
3353:CD143
3348:CD142
3343:CD141
3333:CD138
3328:CD137
3323:CD136
3318:CD135
3313:CD134
3308:CD133
3303:CD132
3298:CD131
3293:CD130
3288:CD129
3283:CD127
3278:CD126
3273:CD125
3268:CD124
3263:CD123
3258:CD122
3241:CD121
3224:CD120
3219:CD119
3214:CD118
3209:CD117
3204:CD116
3199:CD115
3194:CD114
3189:CD113
3184:CD112
3179:CD111
3174:CD110
3169:CD109
3164:CD108
3147:CD107
3142:CD106
3137:CD105
3132:CD104
3127:CD103
3122:CD102
3117:CD101
3101:CD100
1929:S2CID
1782:S2CID
1704:S2CID
1458:CD151
1452:with
1305:is a
936:17221
896:Mouse
891:Human
862:Amigo
410:Mouse
403:Human
350:Start
285:Mouse
249:Start
182:Human
4724:CD18
4668:C4BP
4653:CD59
4641:CLA:
4587:Late
4547:iC3b
3096:CD99
3091:CD98
3086:CD97
3081:CD96
3076:CD95
3071:CD94
3066:CD93
3061:CD92
3057:CD91
3052:CD90
3047:CD89
3042:CD88
3037:CD87
3032:CD86
2995:CD85
2990:CD84
2985:CD83
2980:CD82
2975:CD81
2970:CD80
2953:CD79
2948:CD78
2943:CD74
2938:CD73
2933:CD72
2928:CD71
2923:CD70
2918:CD69
2913:CD68
2876:CD66
2854:CD64
2849:CD63
2827:CD62
2822:CD61
2817:CD59
2812:CD58
2807:CD57
2802:CD56
2797:CD55
2792:CD54
2787:CD53
2782:CD52
2777:CD51
2761:CD50
2724:CD49
2719:CD48
2714:CD47
2709:CD46
2704:CD45
2699:CD44
2694:CD43
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