338:
315:
237:
212:
3481:
589:
596:
344:
243:
3451:
49:
3466:
75:
2278:
Pourakbari R, Hosseini M, Aslani S, Ayoubi-joshaghani MH, Valizadeh H, Roshangar L, et al. (September 2020). "Association between interleukin 2 receptor A gene polymorphisms (rs2104286 and rs12722489) with susceptibility to multiple sclerosis in
Iranian population".
2396:
Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, et al. (September 2007). "Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes".
1434:
and has a molecular mass of around 30.8 kDa. CD25 consists of three domains: extracellular (N-terminus), transmembrane (alpha-helix) and cytoplasmic (C-terminus). However, while extracellular part is able to function as a
351:
250:
1554:) chains or with high-affinity trimeric complex, where also alpha subunit (CD25) constructs the IL-2 receptor and provides enhanced specific binding force. After activation of the receptor by its
1368:
T lymphocytes), where it is considered to be a marker of T cell activation. Additionally, expression of the IL-2 receptor alpha subunit can be found in non-lymphoid tissues such as lungs (
3170:
3480:
6573:
5397:
4111:
7189:
4536:
6699:
1842:
activity without increasing suppressing activity in tumour environment. Antibodies directly against CD25 have been altered to contain ‘activating’
909:
7811:
890:
7585:
173:
7594:
1905:. Therefore, administration of low doses of the cytokine preferentially stimulates T regulatory cells over others. Low-dose IL-2 therapy is used for
6724:
1282:
gene in the population. These SNPs have been linked mainly to susceptibility to immune dysregulation disorders, with majority found in research on
7143:
6938:
1701:
to track disease progression and to indicate outcome for clinical disorders. Especially, it is a hallmark for hyper-activated immune system and
7455:
7450:
5387:
4234:
3177:
3383:
CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo
2124:
Leonard WJ, Donlon TA, Lebo RV, Greene WC (June 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10".
7435:
7347:
7326:
6775:
6709:
6668:
6566:
4514:
2002:
1838:
preventing binding to CD25. This complex should therefore interact with conventional T lymphocytes over T regulatory cells and thus increase
1984:
1320:, where CD25 is expressed constitutively, especially on a subset classified as naturally occurring Tregs. It can also be found on activated
7316:
7184:
7091:
7070:
6821:
6790:
6785:
6729:
6648:
3521:
2440:
7362:
6795:
6623:
6618:
72:
3202:
6968:
6953:
6917:
6887:
6633:
5367:
6229:
4553:
4529:
3911:
1132:
1125:
6559:
4482:
4445:
1847:
7282:
7278:
7274:
5960:
4200:
4196:
4179:
3064:"Chronic Chagas' Disease: Targeting the Interleukin-2 Axis and Regulatory T Cells in a Condition for Which There Is No Treatment"
2863:
2548:
Li Y, Li X, Geng X, Zhao H (October 2022). "The IL-2A receptor pathway and its role in lymphocyte differentiation and function".
1768:
1705:, which may lead to multiple organ system failure. In cancer, increased levels of this soluble protein are diagnostic marker for
3450:
7771:
7038:
5948:
5726:
4313:
4288:
4152:
1613:
functions. All three signalling pathways are important for diverse cellular regulations, in terms of increased survival (anti-
1496:
d ~10−9M). Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (
7836:
7775:
7761:
7721:
6012:
6007:
5953:
5733:
4317:
4292:
4143:
3430:
1967:
1823:
subunit constitutively on the surface, some immunotherapeutic approaches try to use this information for selectivity. NARA1
7841:
7790:
5466:
5392:
4522:
4470:
4169:
4104:
2033:
Spolski R, Li P, Leonard WJ (October 2018). "Biology and regulation of IL-2: from molecular mechanisms to human therapy".
6495:
6490:
6485:
6480:
5407:
4164:
1946:
7695:
2640:
Shipkova M, Wieland E (September 2012). "Surface markers of lymphocyte activation and markers of cell proliferation".
6643:
6460:
1666:
1444:
1657:
Roifman's group was the first to identify immunological consequences of CD25 loss and the patient has suffered from
337:
5696:
4043:
3748:
3740:
3514:
2593:"CD4+CD25-Foxp3+ T cells as a marker of disease activity and organ damage in systemic lupus erythematosus patients"
1874:
and so blocks high-affinity IL-2 receptors on recently activated T cells for interaction with IL-2 as well as IL-2
3324:"Interleukin-2 receptor antagonists and aggressive steroid minimization strategies for kidney transplant patients"
1407:
6264:
5758:
5444:
4391:
3689:
1971:
1950:
314:
1304:
subgroups. Moreover, conserved homologs of this gene are in mouse, rat, dog, cow, chimpanzee and Rhesus monkey.
5903:
5439:
4386:
4334:
3725:
1275:
954:
4544:
1300:
with identical protein functionality are relatively abundant and constant among animal species, especially in
7656:
7635:
6400:
5872:
5867:
5812:
5546:
4995:
3638:
3600:
3595:
2718:"Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: implications for targeted therapy"
1411:
236:
211:
935:
6094:
5817:
3643:
2677:"The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer"
1427:
153:
3382:
3015:"Soluble interleukin-2 receptor levels on admission associated with mortality in coronavirus disease 2019"
5412:
4355:
4351:
3507:
1573:, considering their association with respective cytoplasmic parts of beta and gamma subunits. Downstream
4056:
2081:
Zhou P (October 2022). "Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity".
350:
249:
6124:
4549:
4371:
3987:
3543:
3465:
1578:
2974:"Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma"
2762:
Goudy K, Aydin D, Barzaghi F, Gambineri E, Vignoli M, Ciullini
Mannurita S, et al. (March 2013).
343:
242:
4990:
4347:
4271:
3970:
3756:
3423:
1906:
1764:
1546:
Interleukin-2 can interact with intermediate-affinity dimeric IL-2 receptor, which consists of beta (
1423:
140:
6174:
5069:
4501:
4465:
3996:
3113:
Sahin D, Arenas-Ramirez N, Rath M, Karakus U, Hümbelin M, van Gogh M, et al. (December 2020).
1622:
1087:
1083:
1032:
1028:
161:
1737:
positive patients has a correlation to HIV viral load and so to disease progression. Similarly in
7614:
7574:
7553:
7497:
7465:
7424:
7382:
7336:
7255:
7229:
7173:
7132:
7106:
7080:
6734:
6138:
4420:
4398:
4322:
4309:
4296:
4284:
4252:
4239:
4229:
4205:
4192:
4148:
4139:
4066:
4039:
4030:
3625:
2972:
Janik JE, Morris JC, Pittaluga S, McDonald K, Raffeld M, Jaffe ES, et al. (November 2004).
1108:
1079:
1053:
1024:
7049:
7029:
7008:
6927:
6866:
6810:
6764:
6688:
6593:
5481:
5476:
5471:
5461:
4768:
4696:
4457:
4381:
4134:
4100:
4091:
4061:
4052:
4035:
3633:
3553:
2933:"The IL-2 - IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor"
2764:"Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity"
1772:
1562:
of beta and gamma intracellular domains takes place. This coupling of subunits brings together
1193:
3489:: Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
1649:
may be connected to phenotypic fate of these cells for effector and memory T cells formation.
4825:
4743:
4159:
2229:
Risk Allele
Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls"
1760:
1722:
1582:
225:
1827:
is used in antitumour approaches to preferentially supplement interleukin-2 to conventional
6582:
6062:
5775:
4279:
4187:
4129:
4086:
4013:
3416:
3126:
2172:
2133:
1610:
181:
17:
3377:
3372:
8:
6714:
6608:
6089:
5908:
4496:
4491:
4329:
2465:"IL2RA interleukin 2 receptor subunit alpha [Homo sapiens (human)] - Gene - NCBI"
2441:"Gene: IL2RA (ENSG00000134460) - Orthologues - Homo_sapiens - Ensembl genome browser 108"
2347:
Qu HQ, Bradfield JP, Bélisle A, Grant SF, Hakonarson H, Polychronakos C (December 2009).
1369:
1325:
3130:
2137:
6612:
6585:
5496:
5230:
4486:
4257:
4005:
3538:
3353:
3229:
3147:
3115:"An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer"
3114:
3090:
3063:
3039:
3014:
2905:
2878:
2840:
2815:
2788:
2763:
2617:
2592:
2573:
2516:
2489:
2422:
2373:
2348:
2308:"Toward further mapping of the association between the IL2RA locus and type 1 diabetes"
2255:
2224:
2106:
2058:
1875:
1863:
1690:
1559:
1551:
1283:
185:
3305:
3288:
2879:"Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act"
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
647:
642:
637:
3530:
3397:
3388:
3345:
3310:
3275:
3221:
3152:
3095:
3044:
2995:
2954:
2910:
2845:
2793:
2739:
2698:
2657:
2622:
2577:
2565:
2521:
2414:
2378:
2329:
2260:
2223:
Buhelt S, Søndergaard HB, Oturai A, Ullum H, von Essen MR, Sellebjerg F (June 2019).
2149:
2110:
2098:
2050:
1894:
1816:
1746:
1658:
1606:
1349:
1317:
133:
65:
3233:
3217:
2426:
2062:
1725:. Higher serum levels were correlated with severity and need for hospitalisation of
7806:
6269:
6002:
5923:
5486:
4679:
4605:
4248:
4121:
3962:
3954:
3855:
3847:
3839:
3831:
3357:
3335:
3300:
3265:
3213:
3142:
3134:
3085:
3075:
3034:
3026:
2985:
2944:
2900:
2890:
2835:
2827:
2783:
2775:
2729:
2688:
2649:
2612:
2604:
2557:
2511:
2501:
2406:
2368:
2360:
2319:
2288:
2250:
2240:
2141:
2090:
2042:
1828:
1646:
1642:
1586:
1387:
1361:
1313:
430:
361:
305:
260:
6551:
2734:
2717:
2561:
2094:
1645:, Tfh ( T follicular helper cells). Additionally, strength of IL-2R signalling in
165:
7598:
6329:
4865:
4860:
4783:
3871:
3270:
3253:
2831:
2199:
1910:
1784:
1574:
1377:
1357:
1356:
constitutively express IL2RA in humans. High expression of CD25 is also found on
1287:
1247:
with a length around 51,6 kb. Alternative names for this protein coding gene are
405:
189:
2292:
2007:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1989:
National Center for
Biotechnology Information, U.S. National Library of Medicine
7796:
7786:
7781:
7767:
7753:
7743:
7738:
7685:
7667:
7646:
7625:
7604:
7590:
7564:
7508:
7476:
7440:
7403:
7398:
7393:
7357:
7352:
7266:
7245:
7199:
7148:
7117:
7096:
6831:
6800:
6114:
5536:
5047:
4850:
3772:
3254:"Interleukin-2 and the IL-2 receptor: new insights into structure and function"
3138:
3030:
2990:
2973:
2949:
2932:
2779:
1922:
1879:
1738:
1702:
1570:
1566:
1517:
1513:
1509:
1341:
506:
3340:
3323:
2653:
2046:
588:
7830:
7538:
7194:
7060:
7019:
6943:
6877:
6826:
6780:
6719:
6604:
6084:
5541:
4632:
4224:
4018:
3080:
2895:
2506:
1902:
1804:
1796:
1670:
1626:
1535:
1505:
1501:
1497:
1448:
1440:
1399:
1365:
1353:
1213:
624:
144:, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
2608:
2145:
595:
566:
444:
7712:
7533:
7219:
7214:
7209:
6958:
6897:
6856:
6440:
5748:
5738:
5269:
5235:
4412:
3780:
3349:
3225:
3156:
3099:
3048:
2999:
2958:
2914:
2849:
2816:"The IL-2 - IL-2 receptor pathway: Key to understanding multiple sclerosis"
2797:
2743:
2716:
Jones D, Ibrahim S, Patel K, Luthra R, Duvic M, Medeiros LJ (August 2004).
2702:
2661:
2626:
2569:
2525:
2418:
2382:
2333:
2264:
2102:
2054:
1890:
1886:
1839:
1835:
1780:
1763:, higher levels of sCD25 may be used as a predictor of organ rejection and
1756:
1662:
1590:
1563:
1436:
1403:
1373:
423:
202:
3314:
3279:
2153:
1447:
and therefore needs to oligomerise with other IL-2 receptor subunits. The
1172:
1167:
7543:
7523:
7486:
7321:
7311:
7163:
7158:
6993:
6963:
6902:
6744:
6704:
6663:
6658:
6450:
6099:
5877:
5852:
5551:
5173:
5099:
4573:
3605:
3580:
2490:"Natural Killer Cells: Development, Maturation, and Clinical Utilization"
2464:
2364:
2277:
2245:
1914:
1859:
1788:
1697:. Since sCD25 is produced during immune activation, it is used as one of
1618:
1528:
1297:
1224:
999:
980:
48:
2591:
El-Maraghy N, Ghaly MS, Dessouki O, Nasef SI, Metwally L (August 2018).
1854:
subunit on the surface, which is subsequently recognized and cleared by
7528:
7518:
7413:
7306:
7301:
7122:
6983:
6973:
6907:
6841:
6754:
6749:
6678:
6380:
6104:
5785:
5526:
5402:
5035:
5030:
5025:
4880:
4664:
1918:
1867:
1843:
1538:
have been isolated, but the significance of each is currently unknown.
1431:
1337:
1333:
1329:
1217:
322:
219:
169:
2693:
2676:
2324:
2307:
110:
106:
102:
98:
94:
6998:
6988:
6978:
6851:
6219:
6214:
6209:
6199:
6194:
6189:
6184:
3895:
3887:
3879:
3499:
1855:
1742:
1718:
1698:
1638:
1614:
1395:
854:
389:
376:
288:
275:
177:
6638:
6525:
6425:
6239:
6224:
5427:
5422:
5330:
5020:
3935:
3927:
3919:
3903:
2410:
2306:
Qu HQ, Montpetit A, Ge B, Hudson TJ, Polychronakos C (April 2007).
1824:
1726:
1710:
1706:
1630:
1391:
1271:
1220:
1156:
1352:
in mice, and it has been found that a large proportion of resting
7757:
7240:
6475:
6470:
6465:
6365:
6179:
6169:
5996:
5975:
5970:
5938:
5743:
5663:
5658:
5653:
5648:
5643:
5561:
5254:
5094:
5089:
5084:
5079:
5074:
4545:
4304:
4300:
4047:
3402:
3392:
2642:
Clinica
Chimica Acta; International Journal of Clinical Chemistry
1321:
1236:
966:
921:
839:
835:
3061:
157:
7372:
6415:
6375:
6360:
6344:
6339:
6319:
6314:
6249:
6057:
6027:
5991:
5982:
5795:
5763:
5627:
5622:
5592:
5571:
5531:
5491:
5357:
5335:
5294:
5218:
5213:
5208:
5203:
5198:
5193:
5062:
5057:
5052:
5000:
4985:
4855:
4845:
4808:
4803:
4721:
4716:
4440:
4435:
4430:
4425:
4402:
4342:
4338:
4078:
3711:
1792:
1694:
1555:
1541:
1430:. This bitopic polypeptide is constructed by a sequence of 272
1301:
1264:
1140:
876:
604:
3408:
3112:
1625:. T lymphocytes are influenced by IL-2R signalling in case of
1531:
during activation of T lymphocytes. Also, alternately-spliced
1527:
has been isolated and determined to result from extracellular
7679:
7675:
7671:
7290:
7286:
7270:
6540:
6515:
6435:
6430:
6420:
6410:
6395:
6390:
6385:
6370:
6324:
6309:
6274:
6259:
6254:
6244:
6164:
6159:
6154:
6133:
6129:
6119:
6032:
5933:
5928:
5887:
5837:
5832:
5827:
5822:
5807:
5800:
5780:
5768:
5711:
5706:
5701:
5691:
5686:
5679:
5617:
5607:
5602:
5597:
5587:
5566:
5556:
5521:
5516:
5511:
5506:
5501:
5456:
5451:
5417:
5382:
5377:
5372:
5362:
5350:
5345:
5325:
5320:
5315:
5310:
5264:
5156:
5151:
4970:
4954:
4947:
4942:
4937:
4932:
4927:
4922:
4897:
4875:
4870:
4689:
4684:
4674:
4475:
4095:
4026:
3812:
3764:
3706:
3670:
3665:
3660:
3655:
3650:
3615:
3575:
3565:
1674:
1602:
1598:
1594:
1547:
1488:
1482:
1464:
1457:
1208:
1202:
1192:) is a protein involved in the assembly of the high-affinity
33:
3387:
Overview of all the structural information available in the
2971:
2590:
2222:
6535:
6530:
6520:
6510:
6505:
6500:
6455:
6445:
6405:
6334:
6304:
6299:
6294:
6289:
6284:
6279:
6234:
6204:
6109:
6077:
6072:
6052:
6042:
6037:
6022:
6017:
5918:
5913:
5882:
5862:
5857:
5847:
5842:
5721:
5674:
5634:
5289:
5284:
5279:
5274:
5259:
5250:
5245:
5240:
5225:
5183:
5178:
5168:
5163:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5042:
5015:
5010:
5005:
4980:
4975:
4912:
4907:
4902:
4892:
4887:
4840:
4835:
4830:
4820:
4815:
4798:
4793:
4788:
4778:
4773:
4758:
4753:
4748:
4738:
4733:
4728:
4711:
4706:
4701:
4652:
4620:
4615:
4610:
4593:
4588:
4583:
4578:
3863:
3804:
3796:
3788:
3699:
3610:
3590:
3585:
3570:
3561:
2761:
1240:
1901:
subunit expression on Tregs secures better sensitivity to
1850:, in this case Treg depletion. Antibody marks a cell with
1480:
d ~10−8M) with no signalling ability, while dimeric beta (
1239:
interleukin-2 receptor subunit alpha is encoded by a
7747:
6047:
4659:
4647:
4642:
4637:
4627:
4600:
4568:
3062:
Mengel J, Cardillo F, Pontes-de-Carvalho L (2016-05-13).
2813:
2487:
2173:"IL2RA Gene - GeneCards | IL2RA Protein | IL2RA Antibody"
1734:
1634:
2488:
Abel AM, Yang C, Thakar MS, Malarkannan S (2018-08-13).
1278:(SNP), have been identified in or in close proximity to
413:
2715:
2346:
2123:
1468:), constitute the high-affinity IL-2 receptor complex (
1316:. The highest surface expression of this protein is on
1212:). As the name indicates, this receptor interacts with
2395:
1641:, Tfr (T follicular regulatory cells) and suppressing
1443:, short cytoplasmic domain lacks an ability to induce
805:
positive regulation of activated T cell proliferation
578:
3459:: structure of interleukin-2 with its alpha receptor
2349:"The type I diabetes association of the IL2RA locus"
2225:"Relationship between Multiple Sclerosis-Associated
6581:
2305:
2864:"Entrez Gene: IL2RA interleukin 2 receptor, alpha"
1963:
1961:
1959:
1942:
1940:
1938:
1591:signal transducers and activators of transcription
1577:leads to initiation of three signalling pathways:
1267:is on the short arm of 10th chromosome (10p15.1).
3176:. European Medicines Agency. 2016. Archived from
1348:has been used as a marker to identify CD4+FoxP3+
360:
259:
7828:
2032:
730:negative regulation of defense response to virus
2639:
1956:
1935:
1810:
815:regulation of regulatory T cell differentiation
745:negative regulation of lymphocyte proliferation
32:"CD25" redirects here. Not to be confused with
3401:(Interleukin-2 receptor subunit alpha) at the
3203:"Daclizumab (anti-CD25) in multiple sclerosis"
1968:GRCm38: Ensembl release 89: ENSMUSG00000026770
1885:From the other side, treatment strategies for
1462:chains, together with the common gamma chain (
760:regulation of T cell homeostatic proliferation
6567:
4530:
3515:
3424:
3200:
3171:"Zinbryta Summary of Product Characteristics"
3012:
1848:antibody-dependent cell-mediated cytotoxicity
1799:. For neurological disorders, high levels of
715:positive regulation of T cell differentiation
3251:
3019:International Journal of Infectious Diseases
2814:Peerlings D, Mimpen M, Damoiseaux J (2021).
2674:
2547:
1803:are a sign for increased risk of developing
1542:Signalling cascade of interleukin-2 Receptor
800:negative regulation of inflammatory response
2876:
1947:GRCh38: Ensembl release 89: ENSG00000134460
1390:, such as in most B-cell neoplasms, T-cell
785:positive regulation of T cell proliferation
770:negative regulation of T cell proliferation
725:inflammatory response to antigenic stimulus
6574:
6560:
4537:
4523:
3522:
3508:
3431:
3417:
2930:
2117:
1386:protein can be expressed in many types of
1188:(also called Tac antigen, P55, and mainly
4554:list of human clusters of differentiation
3339:
3304:
3269:
3146:
3089:
3079:
3038:
2989:
2948:
2904:
2894:
2839:
2787:
2733:
2692:
2616:
2515:
2505:
2372:
2323:
2254:
2244:
1609:, they translocate to nucleus to perform
1589:. Regarding JAK-STAT pathway, particular
1422:Interleukin-2 receptor alpha chain is an
7739:Interleukin 14 (taxilin alpha, HMW-BCGF)
3321:
3286:
3258:The Journal of Investigative Dermatology
1689:, has been connected to pathogenesis of
1652:
1593:participate in this signalling cascade:
1223:which plays an important role in immune
825:interleukin-2-mediated signaling pathway
740:activation-induced cell death of T cells
720:regulation of T cell tolerance induction
765:cell surface receptor signaling pathway
27:Mammalian protein found in Homo sapiens
14:
7829:
7037:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
3529:
3013:Kaya H, Kaji M, Usuda D (April 2021).
1717:levels have some significance also in
1680:
1492:) produce a medium-affinity receptor (
1472:d ~10−11M). Homodimeric alpha chains (
775:negative regulation of immune response
6555:
4518:
3503:
3412:
3201:Pfender N, Martin R (December 2014).
2926:
2924:
2820:Journal of Translational Autoimmunity
2809:
2807:
2757:
2755:
2753:
2675:Flynn MJ, Hartley JA (October 2017).
2543:
2541:
2539:
2537:
2535:
1831:. NARA1 binds to the cytokine on the
1360:activated conventional T cells (both
365:
326:
321:
264:
223:
218:
2550:Cytokine & Growth Factor Reviews
2194:
2192:
2167:
2165:
2163:
2083:Cytokine & Growth Factor Reviews
2080:
2076:
2074:
2072:
2028:
2026:
2024:
2022:
2020:
2018:
2016:
1685:Levels of CD25 soluble form, called
1516:), and the CD122 subunit binds also
3293:The Journal of Biological Chemistry
1735:HIV ( human immunodeficiency virus)
1673:) syndrome, caused by mutations in
1629:subtype differentiation: promoting
1476:) result in low-affinity receptor (
820:cytokine-mediated signaling pathway
24:
3252:Kuziel WA, Greene WC (June 1990).
3244:
2921:
2804:
2750:
2532:
1897:and suppression of immune system.
1751:patients have increased levels of
689:intracellular anatomical structure
25:
7853:
3366:
2189:
2160:
2069:
2013:
1665:resembling Immune dysregulation,
1621:, transcriptional regulation and
1186:nterleukin-2 receptor alpha chain
3479:
3464:
3449:
2877:Kalia V, Sarkar S (2018-12-20).
1765:graft-versus-host disease (GVHD)
1312:CD25 is expressed broadly among
684:external side of plasma membrane
594:
587:
349:
342:
336:
313:
248:
241:
235:
210:
47:
7565:Interleukin 27 (interleukin 30)
3438:
3218:10.1016/j.expneurol.2014.04.015
3194:
3163:
3106:
3055:
3006:
2965:
2931:Damoiseaux J (September 2020).
2870:
2856:
2709:
2668:
2633:
2584:
2481:
2457:
2433:
2389:
2340:
2299:
2271:
2216:
638:interleukin-2 receptor activity
2681:British Journal of Haematology
1995:
1977:
1893:diseases need selectivity for
1779:has positive correlation with
1769:hematopoietic transplantations
1587:Ras/Raf/MEK/ERK (MAPK) pathway
1412:tumor infiltrating lymphocytes
1276:single nucleotide polymorphism
1206:) and the common gamma chain (
694:interleukin-2 receptor complex
664:integral component of membrane
605:More reference expression data
567:More reference expression data
13:
1:
3322:Vincenti F (September 2004).
3306:10.1016/S0021-9258(18)49895-X
3287:Waldmann TA (February 1991).
2735:10.1158/1078-0432.CCR-0721-03
2562:10.1016/j.cytogfr.2022.06.004
2095:10.1016/j.cytogfr.2022.06.003
1928:
1862:. Moreover, for treatment of
1773:CVD (cardiovascular diseases)
1408:Waldenstrom macroglobuliaemia
1307:
790:cell population proliferation
334:
233:
7837:Genes on human chromosome 10
3289:"The interleukin-2 receptor"
3271:10.1111/1523-1747.ep12875017
2832:10.1016/j.jtauto.2021.100123
1811:CD25 as a therapeutic target
1647:CD8+ T cytotoxic lymphocytes
1428:type I transmembrane protein
1417:
1394:, some acute nonlymphocytic
7:
7842:Clusters of differentiation
6915:Antisense oligonucleotides:
4550:clusters of differentiation
3474:: cytokine receptor complex
2597:Archives of Medical Science
2293:10.1016/j.mgene.2020.100750
1617:effect), proliferation and
1230:
10:
7858:
3139:10.1038/s41467-020-20220-1
3031:10.1016/j.ijid.2021.03.011
2991:10.1182/blood-2003-11-3922
2950:10.1016/j.clim.2020.108515
2780:10.1016/j.clim.2013.01.004
2035:Nature Reviews. Immunology
1318:regulatory T cells (Tregs)
549:sternocleidomastoid muscle
31:
7731:
7711:
7704:
7655:
7634:
7613:
7573:
7552:
7496:
7464:
7423:
7381:
7335:
7254:
7228:
7172:
7131:
7105:
7079:
7048:
7028:
7007:
6926:
6865:
6809:
6763:
6687:
6592:
6353:
6147:
5896:
5580:
5303:
4963:
4561:
4456:
4411:
4370:
4270:
4216:
4178:
4120:
4077:
4004:
3995:
3986:
3947:
3824:
3733:
3724:
3679:
3624:
3552:
3537:
3444:
3341:10.1007/s00147-004-0750-3
3068:Frontiers in Microbiology
2654:10.1016/j.cca.2011.11.006
2047:10.1038/s41577-018-0046-y
2003:"Mouse PubMed Reference:"
1985:"Human PubMed Reference:"
1907:graft-versus-host disease
1669:, Enteropathy, X-linked (
1424:integral-membrane protein
1326:NK (natural killer) cells
1171:
1166:
1162:
1155:
1139:
1120:
1105:
1101:
1076:
1072:
1065:
1050:
1046:
1021:
1017:
1010:
997:
993:
978:
974:
965:
952:
948:
933:
929:
920:
907:
903:
888:
884:
875:
860:
853:
849:
833:
623:
619:
602:
586:
577:
564:
513:
504:
451:
442:
412:
404:
400:
383:
370:
333:
312:
303:
299:
282:
269:
232:
209:
200:
196:
151:
148:
138:
131:
126:
91:
86:
69:
64:
59:
55:
46:
41:
3328:Transplant International
3081:10.3389/fmicb.2016.00675
2896:10.3389/fimmu.2018.02987
2722:Clinical Cancer Research
2507:10.3389/fimmu.2018.01869
1911:type 1 diabetes mellitus
1785:type 2 diabetes mellitus
1445:intracellular signalling
1288:type 1 diabetes mellitus
7605:Interleukin-29 (IFN-λ1)
6750:Daclizumab (dacliximab)
6735:Tucotuzumab celmoleukin
2883:Frontiers in Immunology
2609:10.5114/aoms.2016.63597
2494:Frontiers in Immunology
2146:10.1126/science.3925551
1270:Several frequent point
1196:, consisting of alpha (
710:Notch signaling pathway
7586:Interferon λ4 (IFN-λ4)
6679:Rilonacept (IL-1 Trap)
4458:Enzyme-linked receptor
3378:Human CD Antigen Chart
3373:Mouse CD Antigen Chart
3210:Experimental Neurology
1451:(IL2) receptor alpha (
1194:interleukin-2 receptor
1133:Chr 2: 11.65 – 11.7 Mb
1126:Chr 10: 6.01 – 6.06 Mb
7509:Interleukin 23 (SGRF)
7190:Cintredekin besudotox
7118:Interleukin 11 (AGIF)
7097:Interleukin 10 (CSIF)
4280:Interleukin receptors
4188:Interleukin receptors
4130:Interleukin receptors
4087:Interleukin receptors
4014:Interleukin receptors
3119:Nature Communications
1653:Clinical significance
1583:PI3K/Akt/mTOR pathway
795:inflammatory response
735:immune system process
643:interleukin-2 binding
226:Chromosome 10 (human)
6583:Interleukin receptor
4330:Interferon receptors
3264:(6 Suppl): 27S–32S.
2648:(17–18): 1338–1349.
2469:www.ncbi.nlm.nih.gov
2365:10.1038/gene.2009.90
2359:(Suppl 1): S42–S48.
2246:10.3390/cells8060634
1733:amount in plasma of
1623:cell differentiation
1611:transcription factor
1486:) and gamma chains (
1370:alveolar macrophages
1336:lineage cells (e.g.
487:smooth muscle tissue
328:Chromosome 2 (mouse)
87:List of PDB id codes
60:Available structures
6715:Denileukin diftitox
3212:. 262 Pt A: 44–51.
3131:2020NatCo..11.6440S
2937:Clinical Immunology
2768:Clinical Immunology
2138:1985Sci...228.1547L
2132:(4707): 1547–1549.
1846:for the purpose of
1789:cardiac sarcoidosis
1719:infectious diseases
1691:autoimmune diseases
1681:CD25 as a biomarker
483:epithelium of colon
367:2 A1|2 8.91 cM
7287:E (interleukin 25)
3539:Chemokine receptor
3531:Cytokine receptors
2353:Genes and Immunity
1876:cross-presentation
1864:multiple sclerosis
1667:Polyendocrinopathy
1659:chronic infections
1560:heterodimerisation
1350:regulatory T cells
1284:multiple sclerosis
955:ENSMUSG00000026770
755:T cell homeostasis
703:Biological process
657:Cellular component
631:Molecular function
467:buccal mucosa cell
7824:
7823:
7820:
7819:
7789:(signals through
7770:(signals through
7756:(signals through
7746:(signals through
7370:Binding proteins:
6700:Adargileukin alfa
6549:
6548:
4512:
4511:
4366:
4365:
4266:
4265:
3982:
3981:
3720:
3719:
3497:
3496:
2984:(10): 3355–3357.
2728:(16): 5587–5594.
2694:10.1111/bjh.14770
2325:10.2337/db06-1555
2177:www.genecards.org
1747:Trypanosoma cruzi
1426:, more precisely
1182:
1181:
1178:
1177:
1151:
1150:
1116:
1115:
1095:
1094:
1061:
1060:
1040:
1039:
1006:
1005:
987:
986:
961:
960:
942:
941:
916:
915:
897:
896:
845:
844:
810:apoptotic process
615:
614:
611:
610:
573:
572:
560:
559:
498:
497:
396:
395:
295:
294:
190:IL2RA - orthologs
122:
121:
118:
117:
70:Ortholog search:
16:(Redirected from
7849:
7812:Efineptakin alfa
7807:Efavaleukin alfa
7709:
7708:
6676:Decoy receptors:
6576:
6569:
6562:
6553:
6552:
4539:
4532:
4525:
4516:
4515:
4249:hormone receptor
4002:
4001:
3993:
3992:
3731:
3730:
3550:
3549:
3524:
3517:
3510:
3501:
3500:
3483:
3468:
3453:
3433:
3426:
3419:
3410:
3409:
3361:
3343:
3318:
3308:
3299:(5): 2681–2684.
3283:
3273:
3238:
3237:
3207:
3198:
3192:
3191:
3189:
3188:
3182:
3175:
3167:
3161:
3160:
3150:
3110:
3104:
3103:
3093:
3083:
3059:
3053:
3052:
3042:
3010:
3004:
3003:
2993:
2969:
2963:
2962:
2952:
2928:
2919:
2918:
2908:
2898:
2874:
2868:
2867:
2860:
2854:
2853:
2843:
2811:
2802:
2801:
2791:
2759:
2748:
2747:
2737:
2713:
2707:
2706:
2696:
2672:
2666:
2665:
2637:
2631:
2630:
2620:
2603:(5): 1033–1040.
2588:
2582:
2581:
2545:
2530:
2529:
2519:
2509:
2485:
2479:
2478:
2476:
2475:
2461:
2455:
2454:
2452:
2451:
2437:
2431:
2430:
2405:(9): 1074–1082.
2393:
2387:
2386:
2376:
2344:
2338:
2337:
2327:
2318:(4): 1174–1176.
2303:
2297:
2296:
2275:
2269:
2268:
2258:
2248:
2220:
2214:
2213:
2211:
2210:
2196:
2187:
2186:
2184:
2183:
2169:
2158:
2157:
2121:
2115:
2114:
2078:
2067:
2066:
2030:
2011:
2010:
1999:
1993:
1992:
1981:
1975:
1965:
1954:
1944:
1741:, caused by the
1579:JAK-STAT pathway
1388:neoplastic cells
1378:Langerhans cells
1164:
1163:
1135:
1128:
1111:
1099:
1098:
1090:
1070:
1069:
1066:RefSeq (protein)
1056:
1044:
1043:
1035:
1015:
1014:
991:
990:
972:
971:
946:
945:
927:
926:
901:
900:
882:
881:
851:
850:
621:
620:
607:
598:
591:
584:
583:
569:
525:secondary oocyte
509:
507:Top expressed in
502:
501:
447:
445:Top expressed in
440:
439:
419:
418:
402:
401:
392:
379:
368:
353:
346:
340:
329:
317:
301:
300:
291:
278:
267:
252:
245:
239:
228:
214:
198:
197:
192:
143:
136:
113:
84:
83:
78:
57:
56:
51:
39:
38:
21:
7857:
7856:
7852:
7851:
7850:
7848:
7847:
7846:
7827:
7826:
7825:
7816:
7727:
7700:
7651:
7630:
7609:
7569:
7548:
7492:
7489:(against IL-22)
7460:
7419:
7416:(against IL-20)
7377:
7331:
7250:
7224:
7168:
7127:
7101:
7075:
7044:
7024:
7003:
6922:
6861:
6805:
6759:
6683:
6588:
6580:
6550:
6545:
6349:
6143:
5892:
5576:
5299:
4959:
4557:
4543:
4513:
4508:
4452:
4407:
4362:
4262:
4212:
4174:
4116:
4073:
3978:
3943:
3872:Osteoprotegerin
3820:
3716:
3675:
3620:
3541:
3533:
3528:
3498:
3493:
3490:
3484:
3475:
3469:
3460:
3454:
3440:
3437:
3369:
3364:
3247:
3245:Further reading
3242:
3241:
3205:
3199:
3195:
3186:
3184:
3180:
3173:
3169:
3168:
3164:
3111:
3107:
3060:
3056:
3011:
3007:
2970:
2966:
2929:
2922:
2875:
2871:
2862:
2861:
2857:
2812:
2805:
2760:
2751:
2714:
2710:
2673:
2669:
2638:
2634:
2589:
2585:
2546:
2533:
2486:
2482:
2473:
2471:
2463:
2462:
2458:
2449:
2447:
2445:www.ensembl.org
2439:
2438:
2434:
2399:Nature Genetics
2394:
2390:
2345:
2341:
2304:
2300:
2276:
2272:
2221:
2217:
2208:
2206:
2204:www.uniprot.org
2198:
2197:
2190:
2181:
2179:
2171:
2170:
2161:
2122:
2118:
2079:
2070:
2041:(10): 648–659.
2031:
2014:
2001:
2000:
1996:
1983:
1982:
1978:
1966:
1957:
1945:
1936:
1931:
1880:dendritic cells
1813:
1761:transplantation
1759:. In regard to
1723:transplantation
1713:. Furthermore,
1683:
1655:
1575:phosphorylation
1544:
1420:
1342:dendritic cells
1310:
1233:
1173:View/Edit Mouse
1168:View/Edit Human
1131:
1124:
1121:Location (UCSC)
1107:
1086:
1082:
1078:
1052:
1031:
1027:
1023:
936:ENSG00000134460
829:
780:immune response
698:
674:plasma membrane
652:
648:protein binding
603:
593:
592:
565:
556:
551:
547:
543:
539:
537:muscle of thigh
535:
531:
527:
523:
519:
505:
494:
489:
485:
481:
477:
473:
469:
465:
461:
457:
443:
387:
374:
366:
356:
355:
354:
347:
327:
304:Gene location (
286:
273:
265:
255:
254:
253:
246:
224:
201:Gene location (
152:
139:
132:
93:
71:
37:
28:
23:
22:
15:
12:
11:
5:
7855:
7845:
7844:
7839:
7822:
7821:
7818:
7817:
7815:
7814:
7809:
7800:
7799:
7797:Interleukin 35
7794:
7787:Interleukin 34
7784:
7782:Interleukin 32
7779:
7768:Interleukin 26
7765:
7754:Interleukin 24
7751:
7744:Interleukin 16
7741:
7735:
7733:
7729:
7728:
7726:
7725:
7717:
7715:
7706:
7702:
7701:
7699:
7698:
7689:
7688:
7686:Interleukin 38
7683:
7668:Interleukin 36
7661:
7659:
7653:
7652:
7650:
7649:
7647:Interleukin 33
7640:
7638:
7632:
7631:
7629:
7628:
7626:Interleukin 31
7619:
7617:
7611:
7610:
7608:
7607:
7602:
7591:Interleukin 28
7588:
7579:
7577:
7571:
7570:
7568:
7567:
7558:
7556:
7550:
7549:
7547:
7546:
7541:
7536:
7531:
7526:
7521:
7512:
7511:
7502:
7500:
7494:
7493:
7491:
7490:
7480:
7479:
7477:Interleukin 22
7470:
7468:
7462:
7461:
7459:
7458:
7453:
7444:
7443:
7441:Interleukin 21
7438:
7429:
7427:
7421:
7420:
7418:
7417:
7407:
7406:
7404:Interleukin 24
7401:
7399:Interleukin 20
7396:
7394:Interleukin 19
7387:
7385:
7379:
7378:
7376:
7375:
7366:
7365:
7360:
7358:Interleukin 37
7355:
7353:Interleukin 18
7350:
7341:
7339:
7333:
7332:
7330:
7329:
7324:
7319:
7314:
7309:
7304:
7295:
7294:
7267:Interleukin 17
7260:
7258:
7252:
7251:
7249:
7248:
7246:Interleukin 15
7243:
7234:
7232:
7226:
7225:
7223:
7222:
7217:
7212:
7203:
7202:
7200:Interleukin 13
7197:
7192:
7187:
7178:
7176:
7170:
7169:
7167:
7166:
7161:
7152:
7151:
7149:Interleukin 12
7146:
7137:
7135:
7129:
7128:
7126:
7125:
7120:
7111:
7109:
7103:
7102:
7100:
7099:
7094:
7085:
7083:
7077:
7076:
7074:
7073:
7064:
7063:
7054:
7052:
7046:
7045:
7043:
7042:
7034:
7032:
7026:
7025:
7023:
7022:
7013:
7011:
7005:
7004:
7002:
7001:
6996:
6991:
6986:
6981:
6976:
6971:
6966:
6961:
6956:
6947:
6946:
6941:
6932:
6930:
6924:
6923:
6921:
6920:
6911:
6910:
6905:
6900:
6891:
6890:
6881:
6880:
6871:
6869:
6863:
6862:
6860:
6859:
6854:
6845:
6844:
6835:
6834:
6832:Interleukin 13
6829:
6824:
6815:
6813:
6807:
6806:
6804:
6803:
6801:Promegapoietin
6798:
6793:
6788:
6783:
6778:
6769:
6767:
6761:
6760:
6758:
6757:
6752:
6747:
6738:
6737:
6732:
6727:
6725:Pegaldesleukin
6722:
6717:
6712:
6707:
6702:
6693:
6691:
6685:
6684:
6682:
6681:
6672:
6671:
6666:
6661:
6652:
6651:
6646:
6641:
6636:
6627:
6626:
6621:
6616:
6598:
6596:
6590:
6589:
6579:
6578:
6571:
6564:
6556:
6547:
6546:
6544:
6543:
6538:
6533:
6528:
6523:
6518:
6513:
6508:
6503:
6498:
6493:
6488:
6483:
6478:
6473:
6468:
6463:
6458:
6453:
6448:
6443:
6438:
6433:
6428:
6423:
6418:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6368:
6363:
6357:
6355:
6351:
6350:
6348:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6157:
6151:
6149:
6145:
6144:
6142:
6141:
6136:
6127:
6122:
6117:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6081:
6080:
6075:
6065:
6060:
6055:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5994:
5985:
5980:
5979:
5978:
5973:
5963:
5958:
5957:
5956:
5951:
5941:
5936:
5931:
5926:
5921:
5916:
5911:
5906:
5900:
5898:
5894:
5893:
5891:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5804:
5803:
5798:
5788:
5783:
5778:
5773:
5772:
5771:
5766:
5761:
5751:
5746:
5741:
5736:
5731:
5730:
5729:
5724:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5683:
5682:
5677:
5667:
5661:
5656:
5651:
5646:
5637:
5632:
5631:
5630:
5625:
5620:
5610:
5605:
5600:
5595:
5590:
5584:
5582:
5578:
5577:
5575:
5574:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5448:
5447:
5442:
5432:
5431:
5430:
5425:
5415:
5410:
5405:
5400:
5395:
5390:
5385:
5380:
5375:
5370:
5365:
5360:
5355:
5354:
5353:
5348:
5338:
5333:
5328:
5323:
5318:
5313:
5307:
5305:
5301:
5300:
5298:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5248:
5243:
5238:
5233:
5228:
5223:
5222:
5221:
5216:
5211:
5206:
5201:
5196:
5186:
5181:
5176:
5171:
5166:
5161:
5160:
5159:
5154:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5104:
5103:
5102:
5097:
5092:
5087:
5082:
5077:
5067:
5066:
5065:
5060:
5055:
5045:
5040:
5039:
5038:
5033:
5028:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4967:
4965:
4961:
4960:
4958:
4957:
4952:
4951:
4950:
4945:
4940:
4935:
4930:
4925:
4915:
4910:
4905:
4900:
4895:
4890:
4885:
4884:
4883:
4878:
4873:
4868:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4812:
4811:
4806:
4796:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4725:
4724:
4719:
4709:
4704:
4699:
4694:
4693:
4692:
4687:
4682:
4677:
4667:
4662:
4657:
4656:
4655:
4645:
4640:
4635:
4630:
4625:
4624:
4623:
4618:
4613:
4603:
4598:
4597:
4596:
4591:
4586:
4581:
4576:
4565:
4563:
4559:
4558:
4542:
4541:
4534:
4527:
4519:
4510:
4509:
4507:
4506:
4505:
4504:
4499:
4494:
4480:
4479:
4478:
4473:
4462:
4460:
4454:
4453:
4451:
4450:
4449:
4448:
4443:
4438:
4433:
4428:
4417:
4415:
4409:
4408:
4406:
4405:
4396:
4395:
4394:
4389:
4379:
4376:
4374:
4372:Ig superfamily
4368:
4367:
4364:
4363:
4361:
4360:
4359:
4358:
4345:
4327:
4326:
4325:
4320:
4307:
4276:
4274:
4268:
4267:
4264:
4263:
4261:
4260:
4255:
4245:
4244:
4243:
4242:
4240:Thrombopoietin
4237:
4232:
4220:
4218:
4214:
4213:
4211:
4210:
4209:
4208:
4203:
4184:
4182:
4176:
4175:
4173:
4172:
4167:
4162:
4157:
4156:
4155:
4146:
4137:
4126:
4124:
4118:
4117:
4115:
4114:
4109:
4108:
4107:
4098:
4083:
4081:
4075:
4074:
4072:
4071:
4070:
4069:
4064:
4059:
4050:
4033:
4010:
4008:
3999:
3990:
3984:
3983:
3980:
3979:
3977:
3976:
3968:
3960:
3951:
3949:
3945:
3944:
3942:
3941:
3933:
3925:
3917:
3909:
3901:
3893:
3885:
3877:
3869:
3861:
3853:
3845:
3837:
3828:
3826:
3822:
3821:
3819:
3818:
3810:
3802:
3794:
3786:
3778:
3770:
3762:
3754:
3746:
3737:
3735:
3728:
3722:
3721:
3718:
3717:
3715:
3714:
3709:
3704:
3703:
3702:
3694:
3693:
3692:
3683:
3681:
3677:
3676:
3674:
3673:
3668:
3663:
3658:
3653:
3648:
3647:
3646:
3641:
3630:
3628:
3622:
3621:
3619:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3558:
3556:
3547:
3535:
3534:
3527:
3526:
3519:
3512:
3504:
3495:
3494:
3492:
3491:
3485:
3478:
3476:
3470:
3463:
3461:
3455:
3448:
3445:
3442:
3441:
3436:
3435:
3428:
3421:
3413:
3407:
3406:
3385:
3380:
3375:
3368:
3367:External links
3365:
3363:
3362:
3334:(8): 395–401.
3319:
3284:
3248:
3246:
3243:
3240:
3239:
3193:
3162:
3105:
3054:
3005:
2964:
2920:
2869:
2855:
2803:
2774:(3): 248–261.
2749:
2708:
2667:
2632:
2583:
2531:
2480:
2456:
2432:
2411:10.1038/ng2102
2388:
2339:
2298:
2270:
2215:
2188:
2159:
2116:
2068:
2012:
1994:
1976:
1955:
1933:
1932:
1930:
1927:
1923:systemic lupus
1917:virus-induced
1866:, drug called
1812:
1809:
1757:autoantibodies
1739:Chagas disease
1703:cytokine storm
1682:
1679:
1654:
1651:
1543:
1540:
1419:
1416:
1400:neuroblastomas
1354:memory T cells
1309:
1306:
1259:. Location of
1232:
1229:
1180:
1179:
1176:
1175:
1170:
1160:
1159:
1153:
1152:
1149:
1148:
1146:
1144:
1137:
1136:
1129:
1122:
1118:
1117:
1114:
1113:
1103:
1102:
1096:
1093:
1092:
1074:
1073:
1067:
1063:
1062:
1059:
1058:
1048:
1047:
1041:
1038:
1037:
1019:
1018:
1012:
1008:
1007:
1004:
1003:
995:
994:
988:
985:
984:
976:
975:
969:
963:
962:
959:
958:
950:
949:
943:
940:
939:
931:
930:
924:
918:
917:
914:
913:
905:
904:
898:
895:
894:
886:
885:
879:
873:
872:
867:
862:
858:
857:
847:
846:
843:
842:
831:
830:
828:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
660:
658:
654:
653:
651:
650:
645:
640:
634:
632:
628:
627:
617:
616:
613:
612:
609:
608:
600:
599:
581:
575:
574:
571:
570:
562:
561:
558:
557:
555:
554:
550:
546:
545:primary oocyte
542:
538:
534:
530:
526:
522:
518:
514:
511:
510:
499:
496:
495:
493:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
449:
448:
436:
435:
427:
416:
410:
409:
406:RNA expression
398:
397:
394:
393:
385:
381:
380:
372:
369:
364:
358:
357:
348:
341:
335:
331:
330:
325:
319:
318:
310:
309:
297:
296:
293:
292:
284:
280:
279:
271:
268:
263:
257:
256:
247:
240:
234:
230:
229:
222:
216:
215:
207:
206:
194:
193:
150:
146:
145:
137:
129:
128:
124:
123:
120:
119:
116:
115:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
9:
6:
4:
3:
2:
7854:
7843:
7840:
7838:
7835:
7834:
7832:
7813:
7810:
7808:
7805:
7802:
7801:
7798:
7795:
7792:
7788:
7785:
7783:
7780:
7777:
7773:
7769:
7766:
7763:
7759:
7755:
7752:
7749:
7745:
7742:
7740:
7737:
7736:
7734:
7730:
7723:
7719:
7718:
7716:
7714:
7710:
7707:
7703:
7697:
7694:
7691:
7690:
7687:
7684:
7681:
7677:
7673:
7669:
7666:
7663:
7662:
7660:
7658:
7654:
7648:
7645:
7642:
7641:
7639:
7637:
7633:
7627:
7624:
7621:
7620:
7618:
7616:
7612:
7606:
7603:
7600:
7596:
7592:
7589:
7587:
7584:
7581:
7580:
7578:
7576:
7572:
7566:
7563:
7560:
7559:
7557:
7555:
7551:
7545:
7542:
7540:
7539:Tildrakizumab
7537:
7535:
7532:
7530:
7527:
7525:
7522:
7520:
7517:
7514:
7513:
7510:
7507:
7504:
7503:
7501:
7499:
7495:
7488:
7485:
7482:
7481:
7478:
7475:
7472:
7471:
7469:
7467:
7463:
7457:
7454:
7452:
7449:
7446:
7445:
7442:
7439:
7437:
7434:
7431:
7430:
7428:
7426:
7422:
7415:
7412:
7409:
7408:
7405:
7402:
7400:
7397:
7395:
7392:
7389:
7388:
7386:
7384:
7380:
7374:
7371:
7368:
7367:
7364:
7361:
7359:
7356:
7354:
7351:
7349:
7346:
7343:
7342:
7340:
7338:
7334:
7328:
7325:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7297:
7296:
7292:
7288:
7284:
7280:
7276:
7272:
7268:
7265:
7262:
7261:
7259:
7257:
7253:
7247:
7244:
7242:
7239:
7236:
7235:
7233:
7231:
7227:
7221:
7218:
7216:
7213:
7211:
7208:
7205:
7204:
7201:
7198:
7196:
7195:Interleukin 4
7193:
7191:
7188:
7186:
7183:
7180:
7179:
7177:
7175:
7171:
7165:
7162:
7160:
7157:
7154:
7153:
7150:
7147:
7145:
7144:Edodekin alfa
7142:
7139:
7138:
7136:
7134:
7130:
7124:
7121:
7119:
7116:
7113:
7112:
7110:
7108:
7104:
7098:
7095:
7093:
7090:
7087:
7086:
7084:
7082:
7078:
7072:
7069:
7066:
7065:
7062:
7061:Interleukin 9
7059:
7056:
7055:
7053:
7051:
7047:
7040:
7036:
7035:
7033:
7031:
7027:
7021:
7020:Interleukin 7
7018:
7015:
7014:
7012:
7010:
7006:
7000:
6997:
6995:
6992:
6990:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6967:
6965:
6962:
6960:
6957:
6955:
6952:
6949:
6948:
6945:
6944:Interleukin 6
6942:
6940:
6939:Atexakin alfa
6937:
6934:
6933:
6931:
6929:
6925:
6919:
6916:
6913:
6912:
6909:
6906:
6904:
6901:
6899:
6896:
6893:
6892:
6889:
6886:
6883:
6882:
6879:
6878:Interleukin 5
6876:
6873:
6872:
6870:
6868:
6864:
6858:
6855:
6853:
6850:
6847:
6846:
6843:
6840:
6837:
6836:
6833:
6830:
6828:
6827:Interleukin 4
6825:
6823:
6820:
6817:
6816:
6814:
6812:
6808:
6802:
6799:
6797:
6794:
6792:
6789:
6787:
6784:
6782:
6781:Interleukin 3
6779:
6777:
6774:
6771:
6770:
6768:
6766:
6762:
6756:
6753:
6751:
6748:
6746:
6743:
6740:
6739:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6720:Interleukin 2
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6695:
6694:
6692:
6690:
6686:
6680:
6677:
6674:
6673:
6670:
6667:
6665:
6662:
6660:
6657:
6654:
6653:
6650:
6647:
6645:
6642:
6640:
6637:
6635:
6632:
6629:
6628:
6625:
6622:
6620:
6617:
6614:
6610:
6606:
6605:Interleukin 1
6603:
6600:
6599:
6597:
6595:
6591:
6587:
6584:
6577:
6572:
6570:
6565:
6563:
6558:
6557:
6554:
6542:
6539:
6537:
6534:
6532:
6529:
6527:
6524:
6522:
6519:
6517:
6514:
6512:
6509:
6507:
6504:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6472:
6469:
6467:
6464:
6462:
6459:
6457:
6454:
6452:
6449:
6447:
6444:
6442:
6439:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6372:
6369:
6367:
6364:
6362:
6359:
6358:
6356:
6352:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6316:
6313:
6311:
6308:
6306:
6303:
6301:
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6241:
6238:
6236:
6233:
6231:
6228:
6226:
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6156:
6153:
6152:
6150:
6146:
6140:
6137:
6135:
6131:
6128:
6126:
6123:
6121:
6118:
6116:
6113:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6079:
6076:
6074:
6071:
6070:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5998:
5995:
5993:
5989:
5986:
5984:
5981:
5977:
5974:
5972:
5969:
5968:
5967:
5964:
5962:
5959:
5955:
5952:
5950:
5947:
5946:
5945:
5942:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5901:
5899:
5895:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5802:
5799:
5797:
5794:
5793:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5770:
5767:
5765:
5762:
5760:
5757:
5756:
5755:
5752:
5750:
5747:
5745:
5742:
5740:
5737:
5735:
5732:
5728:
5725:
5723:
5720:
5719:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5681:
5678:
5676:
5673:
5672:
5671:
5668:
5665:
5662:
5660:
5657:
5655:
5652:
5650:
5647:
5645:
5641:
5638:
5636:
5633:
5629:
5626:
5624:
5621:
5619:
5616:
5615:
5614:
5611:
5609:
5606:
5604:
5601:
5599:
5596:
5594:
5591:
5589:
5586:
5585:
5583:
5579:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5446:
5443:
5441:
5438:
5437:
5436:
5433:
5429:
5426:
5424:
5421:
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5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5352:
5349:
5347:
5344:
5343:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5308:
5306:
5302:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5191:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5158:
5155:
5153:
5150:
5149:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5072:
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5068:
5064:
5061:
5059:
5056:
5054:
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5050:
5049:
5046:
5044:
5041:
5037:
5034:
5032:
5029:
5027:
5024:
5023:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4968:
4966:
4962:
4956:
4953:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4920:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4863:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4810:
4807:
4805:
4802:
4801:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4723:
4720:
4718:
4715:
4714:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4672:
4671:
4668:
4666:
4663:
4661:
4658:
4654:
4651:
4650:
4649:
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4644:
4641:
4639:
4636:
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4631:
4629:
4626:
4622:
4619:
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4614:
4612:
4609:
4608:
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4604:
4602:
4599:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4571:
4570:
4567:
4566:
4564:
4560:
4555:
4551:
4547:
4540:
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4533:
4528:
4526:
4521:
4520:
4517:
4503:
4500:
4498:
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4489:
4488:
4484:
4481:
4477:
4474:
4472:
4469:
4468:
4467:
4464:
4463:
4461:
4459:
4455:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4423:
4422:
4419:
4418:
4416:
4414:
4410:
4404:
4400:
4397:
4393:
4390:
4388:
4385:
4384:
4383:
4380:
4378:
4377:
4375:
4373:
4369:
4357:
4353:
4349:
4346:
4344:
4340:
4336:
4333:
4332:
4331:
4328:
4324:
4321:
4319:
4315:
4311:
4308:
4306:
4302:
4298:
4294:
4290:
4286:
4283:
4282:
4281:
4278:
4277:
4275:
4273:
4269:
4259:
4256:
4254:
4250:
4247:
4246:
4241:
4238:
4236:
4233:
4231:
4228:
4227:
4226:
4225:CSF receptors
4222:
4221:
4219:
4215:
4207:
4204:
4202:
4198:
4194:
4191:
4190:
4189:
4186:
4185:
4183:
4181:
4177:
4171:
4168:
4166:
4163:
4161:
4158:
4154:
4150:
4147:
4145:
4141:
4138:
4136:
4133:
4132:
4131:
4128:
4127:
4125:
4123:
4119:
4113:
4110:
4106:
4102:
4099:
4097:
4093:
4090:
4089:
4088:
4085:
4084:
4082:
4080:
4076:
4068:
4065:
4063:
4060:
4058:
4054:
4051:
4049:
4045:
4041:
4037:
4034:
4032:
4028:
4024:
4020:
4017:
4016:
4015:
4012:
4011:
4009:
4007:
4003:
4000:
3998:
3994:
3991:
3989:
3985:
3975:
3972:
3969:
3967:
3964:
3961:
3959:
3956:
3953:
3952:
3950:
3946:
3940:
3937:
3934:
3932:
3929:
3926:
3924:
3921:
3918:
3916:
3913:
3910:
3908:
3905:
3902:
3900:
3897:
3894:
3892:
3889:
3886:
3884:
3881:
3878:
3876:
3873:
3870:
3868:
3865:
3862:
3860:
3857:
3854:
3852:
3849:
3846:
3844:
3841:
3838:
3836:
3833:
3830:
3829:
3827:
3823:
3817:
3814:
3811:
3809:
3806:
3803:
3801:
3798:
3795:
3793:
3790:
3787:
3785:
3782:
3779:
3777:
3774:
3771:
3769:
3766:
3763:
3761:
3758:
3755:
3753:
3750:
3747:
3745:
3742:
3739:
3738:
3736:
3732:
3729:
3727:
3723:
3713:
3710:
3708:
3705:
3701:
3698:
3697:
3695:
3691:
3688:
3687:
3685:
3684:
3682:
3678:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3645:
3642:
3640:
3637:
3636:
3635:
3632:
3631:
3629:
3627:
3623:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3563:
3560:
3559:
3557:
3555:
3551:
3548:
3545:
3540:
3536:
3532:
3525:
3520:
3518:
3513:
3511:
3506:
3505:
3502:
3488:
3482:
3477:
3473:
3467:
3462:
3458:
3452:
3447:
3446:
3443:
3434:
3429:
3427:
3422:
3420:
3415:
3414:
3411:
3404:
3400:
3399:
3394:
3390:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3370:
3359:
3355:
3351:
3347:
3342:
3337:
3333:
3329:
3325:
3320:
3316:
3312:
3307:
3302:
3298:
3294:
3290:
3285:
3281:
3277:
3272:
3267:
3263:
3259:
3255:
3250:
3249:
3235:
3231:
3227:
3223:
3219:
3215:
3211:
3204:
3197:
3183:on 2018-06-14
3179:
3172:
3166:
3158:
3154:
3149:
3144:
3140:
3136:
3132:
3128:
3124:
3120:
3116:
3109:
3101:
3097:
3092:
3087:
3082:
3077:
3073:
3069:
3065:
3058:
3050:
3046:
3041:
3036:
3032:
3028:
3024:
3020:
3016:
3009:
3001:
2997:
2992:
2987:
2983:
2979:
2975:
2968:
2960:
2956:
2951:
2946:
2942:
2938:
2934:
2927:
2925:
2916:
2912:
2907:
2902:
2897:
2892:
2888:
2884:
2880:
2873:
2865:
2859:
2851:
2847:
2842:
2837:
2833:
2829:
2825:
2821:
2817:
2810:
2808:
2799:
2795:
2790:
2785:
2781:
2777:
2773:
2769:
2765:
2758:
2756:
2754:
2745:
2741:
2736:
2731:
2727:
2723:
2719:
2712:
2704:
2700:
2695:
2690:
2686:
2682:
2678:
2671:
2663:
2659:
2655:
2651:
2647:
2643:
2636:
2628:
2624:
2619:
2614:
2610:
2606:
2602:
2598:
2594:
2587:
2579:
2575:
2571:
2567:
2563:
2559:
2555:
2551:
2544:
2542:
2540:
2538:
2536:
2527:
2523:
2518:
2513:
2508:
2503:
2499:
2495:
2491:
2484:
2470:
2466:
2460:
2446:
2442:
2436:
2428:
2424:
2420:
2416:
2412:
2408:
2404:
2400:
2392:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2354:
2350:
2343:
2335:
2331:
2326:
2321:
2317:
2313:
2309:
2302:
2294:
2290:
2286:
2282:
2274:
2266:
2262:
2257:
2252:
2247:
2242:
2238:
2234:
2230:
2228:
2219:
2205:
2201:
2195:
2193:
2178:
2174:
2168:
2166:
2164:
2155:
2151:
2147:
2143:
2139:
2135:
2131:
2127:
2120:
2112:
2108:
2104:
2100:
2096:
2092:
2088:
2084:
2077:
2075:
2073:
2064:
2060:
2056:
2052:
2048:
2044:
2040:
2036:
2029:
2027:
2025:
2023:
2021:
2019:
2017:
2008:
2004:
1998:
1990:
1986:
1980:
1973:
1969:
1964:
1962:
1960:
1952:
1948:
1943:
1941:
1939:
1934:
1926:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1892:
1888:
1883:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1834:
1830:
1826:
1822:
1818:
1808:
1806:
1805:schizophrenia
1802:
1798:
1797:heart failure
1794:
1790:
1786:
1782:
1778:
1774:
1771:. Concerning
1770:
1766:
1762:
1758:
1754:
1750:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1678:
1676:
1672:
1668:
1664:
1660:
1650:
1648:
1644:
1640:
1636:
1632:
1628:
1627:CD4+ T helper
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1565:
1564:Janus kinases
1561:
1557:
1553:
1550:) and gamma (
1549:
1539:
1537:
1534:
1530:
1526:
1521:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1490:
1485:
1484:
1479:
1475:
1471:
1467:
1466:
1461:
1459:
1454:
1450:
1449:interleukin-2
1446:
1442:
1441:interleukin-2
1438:
1433:
1429:
1425:
1415:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1379:
1375:
1374:Kupffer cells
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1305:
1303:
1299:
1295:
1291:
1289:
1285:
1281:
1277:
1273:
1268:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1228:
1226:
1222:
1219:
1215:
1214:interleukin-2
1211:
1210:
1205:
1204:
1199:
1195:
1191:
1187:
1174:
1169:
1165:
1161:
1158:
1154:
1147:
1145:
1142:
1138:
1134:
1130:
1127:
1123:
1119:
1112:
1110:
1104:
1100:
1097:
1091:
1089:
1085:
1081:
1075:
1071:
1068:
1064:
1057:
1055:
1049:
1045:
1042:
1036:
1034:
1030:
1026:
1020:
1016:
1013:
1011:RefSeq (mRNA)
1009:
1002:
1001:
996:
992:
989:
983:
982:
977:
973:
970:
968:
964:
957:
956:
951:
947:
944:
938:
937:
932:
928:
925:
923:
919:
912:
911:
906:
902:
899:
893:
892:
887:
883:
880:
878:
874:
871:
868:
866:
863:
859:
856:
852:
848:
841:
837:
832:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
661:
659:
656:
655:
649:
646:
644:
641:
639:
636:
635:
633:
630:
629:
626:
625:Gene ontology
622:
618:
606:
601:
597:
590:
585:
582:
580:
576:
568:
563:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
515:
512:
508:
503:
500:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
453:
450:
446:
441:
438:
437:
434:
432:
428:
426:
425:
421:
420:
417:
415:
411:
407:
403:
399:
391:
386:
382:
378:
373:
363:
359:
352:
345:
339:
332:
324:
320:
316:
311:
307:
302:
298:
290:
285:
281:
277:
272:
262:
258:
251:
244:
238:
231:
227:
221:
217:
213:
208:
204:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
147:
142:
135:
130:
125:
114:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
35:
30:
19:
7803:
7791:M-CSFR/CSF1R
7778:heterodimer)
7764:heterodimer)
7693:Antagonists:
7692:
7664:
7643:
7622:
7582:
7561:
7534:Risankizumab
7515:
7505:
7483:
7473:
7456:NNC0114-0006
7451:NNC0114-0005
7447:
7432:
7410:
7390:
7369:
7344:
7298:
7263:
7237:
7220:Tralokinumab
7215:Lebrikizumab
7210:Anrukinzumab
7206:
7181:
7155:
7140:
7114:
7088:
7067:
7057:
7016:
6959:Clazakizumab
6950:
6935:
6914:
6898:Benralizumab
6894:
6885:Antagonists:
6884:
6874:
6857:Pascolizumab
6848:
6839:Antagonists:
6838:
6818:
6772:
6741:
6696:
6675:
6655:
6631:Antagonists:
6630:
6601:
6067:
5987:
5965:
5943:
5790:
5753:
5716:
5669:
5639:
5612:
5434:
5340:
5188:
4917:
4763:
4669:
4413:IL 17 family
4022:
3973:
3965:
3957:
3938:
3930:
3922:
3914:
3906:
3898:
3890:
3882:
3874:
3866:
3858:
3850:
3842:
3834:
3815:
3807:
3799:
3791:
3783:
3781:Fas receptor
3775:
3767:
3759:
3751:
3743:
3726:TNF receptor
3486:
3471:
3456:
3396:
3331:
3327:
3296:
3292:
3261:
3257:
3209:
3196:
3185:. Retrieved
3178:the original
3165:
3122:
3118:
3108:
3071:
3067:
3057:
3022:
3018:
3008:
2981:
2977:
2967:
2940:
2936:
2886:
2882:
2872:
2858:
2823:
2819:
2771:
2767:
2725:
2721:
2711:
2687:(1): 20–35.
2684:
2680:
2670:
2645:
2641:
2635:
2600:
2596:
2586:
2553:
2549:
2497:
2493:
2483:
2472:. Retrieved
2468:
2459:
2448:. Retrieved
2444:
2435:
2402:
2398:
2391:
2356:
2352:
2342:
2315:
2311:
2301:
2284:
2280:
2273:
2236:
2232:
2226:
2218:
2207:. Retrieved
2203:
2180:. Retrieved
2176:
2129:
2125:
2119:
2086:
2082:
2038:
2034:
2006:
1997:
1988:
1979:
1898:
1891:inflammatory
1884:
1871:
1856:myeloid cell
1851:
1836:binding site
1832:
1829:CD8+ T cells
1820:
1814:
1800:
1781:hypertension
1776:
1752:
1745:
1730:
1714:
1686:
1684:
1663:autoimmunity
1656:
1607:dimerisation
1545:
1532:
1524:
1522:
1493:
1487:
1481:
1477:
1473:
1469:
1463:
1456:
1455:) and beta (
1452:
1437:binding site
1421:
1404:mastocytosis
1383:
1382:
1376:) and skin (
1345:
1311:
1293:
1292:
1279:
1269:
1260:
1256:
1252:
1248:
1244:
1234:
1207:
1201:
1197:
1189:
1185:
1183:
1106:
1088:NP_001295172
1084:NP_001295171
1077:
1051:
1033:NM_001308243
1029:NM_001308242
1022:
998:
979:
953:
934:
908:
889:
869:
864:
750:MAPK cascade
679:cell surface
429:
422:
149:External IDs
92:
29:
7544:Ustekinumab
7524:Briakinumab
7516:Antibodies:
7487:Fezakinumab
7484:Antibodies:
7448:Antibodies:
7436:Denenicokin
7411:Antibodies:
7348:Iboctadekin
7327:Vunakizumab
7322:Secukinumab
7312:Perakizumab
7299:Antibodies:
7207:Antibodies:
7164:Ustekinumab
7159:Briakinumab
7156:Antibodies:
7068:Antibodies:
6994:Tocilizumab
6964:Elsilimomab
6951:Antibodies:
6903:Mepolizumab
6895:Antibodies:
6849:Antibodies:
6776:Daniplestim
6745:Basiliximab
6742:Antibodies:
6710:Celmoleukin
6705:Aldesleukin
6669:Lutikizumab
6664:Gevokizumab
6659:Canakinumab
6656:Antibodies:
3899:(TNFRSF13C)
3891:(TNFRSF13B)
3883:(TNFRSF12A)
3875:(TNFRSF11B)
3867:(TNFRSF11A)
3859:(TNFRSF10D)
3851:(TNFRSF10C)
3843:(TNFRSF10B)
3835:(TNFRSF10A)
3439:PDB gallery
3125:(1): 6440.
3025:: 522–524.
1915:hepatitis C
1860:Fc receptor
1661:and severe
1619:cell growth
1529:proteolysis
1432:amino acids
1338:macrophages
1332:, and some
1298:orthologues
1225:homeostasis
1218:pleiotropic
529:granulocyte
479:granulocyte
471:gallbladder
388:11,698,004
375:11,647,618
127:Identifiers
7831:Categories
7599:B (IFN-λ3)
7595:A (IFN-λ2)
7529:Guselkumab
7519:Brazikumab
7414:Fletikumab
7317:Remtolumab
7307:Ixekizumab
7302:Brodalumab
7185:Binetrakin
7123:Oprelvekin
7092:Ilodecakin
7071:Enokizumab
6984:Siltuximab
6974:Olokizumab
6908:Reslizumab
6842:Pitrakinra
6822:Binetrakin
6791:Milodistim
6786:Leridistim
6755:Inolimomab
6730:Teceleukin
6649:Isunakinra
6586:modulators
4552:(see also
3974:(TNFRSF27)
3966:(TNFRSF25)
3958:(TNFRSF21)
3939:(TNFRSF19)
3931:(TNFRSF18)
3923:(TNFRSF17)
3915:(TNFRSF16)
3907:(TNFRSF14)
3792:(TNFRSF6B)
3752:(TNFRSF1B)
3744:(TNFRSF1A)
3187:2016-12-09
2943:: 108515.
2826:: 100123.
2474:2023-01-25
2450:2023-01-25
2287:: 100750.
2239:(6): 634.
2209:2023-01-25
2182:2023-01-25
1974:, May 2017
1953:, May 2017
1929:References
1919:vasculitis
1887:autoimmune
1868:daclizumab
1844:Fc regions
1729:patients.
1699:biomarkers
1605:and after
1372:), liver (
1330:thymocytes
1314:leukocytes
1308:Expression
1235:The human
533:lymph node
455:lymph node
433:(ortholog)
287:6,062,370
274:6,010,689
170:HomoloGene
7804:Unsorted:
7665:Agonists:
7644:Agonists:
7623:Agonists:
7583:Agonists:
7562:Agonists:
7506:Agonists:
7474:Agonists:
7433:Agonists:
7391:Agonists:
7363:Tadekinig
7345:Agonists:
7264:Agonists:
7238:Agonists:
7182:Agonists:
7141:Agonists:
7115:Agonists:
7089:Agonists:
7058:Agonists:
7017:Agonists:
6999:Levilimab
6989:Sirukumab
6979:Sarilumab
6936:Agonists:
6875:Agonists:
6852:Dupilumab
6819:Agonists:
6796:Muplestim
6773:Agonists:
6697:Agonists:
6624:Pifonakin
6619:Mobenakin
6602:Agonists:
4258:prolactin
3816:(TNFRSF9)
3808:(TNFRSF8)
3800:(TNFRSF7)
3784:(TNFRSF6)
3776:(TNFRSF5)
3768:(TNFRSF4)
3760:(TNFRSF3)
2578:250252097
2556:: 66–79.
2281:Meta Gene
2200:"UniProt"
2111:250200065
2089:: 80–88.
1870:binds to
1840:cytotoxic
1743:protozoan
1615:apoptotic
1418:Structure
1396:leukemias
1392:lymphomas
1286:(MS) and
1272:mutations
1263:in human
1200:), beta (
1109:NP_032393
1080:NP_000408
1054:NM_008367
1025:NM_000417
855:Orthologs
553:esophagus
178:GeneCards
7758:IL-22Rα1
7724:instead.
7041:instead.
6969:mAb 1339
6954:ARGX-109
6918:TPI ASM8
6888:YM-90709
6639:Anakinra
6634:AF-12198
4546:Proteins
4487:TGF-beta
3988:JAK-STAT
3936:TAJ/TROY
3350:15365604
3234:32444028
3226:24768797
3157:33353953
3100:27242702
3049:33711520
3000:15205267
2959:32619646
2915:30619342
2889:: 2987.
2850:35005590
2798:23416241
2744:15328201
2703:28556984
2662:22120733
2627:30154885
2570:35803834
2526:30150991
2500:: 1869.
2427:13940200
2419:17676041
2383:19956099
2334:17395754
2312:Diabetes
2265:31242590
2103:35803833
2063:51939991
2055:30089912
1970:–
1949:–
1825:antibody
1819:express
1775:soluble
1727:COVID-19
1711:lymphoma
1707:leukemia
1523:Soluble
1231:Genetics
1221:cytokine
1157:Wikidata
834:Sources:
669:membrane
459:appendix
7776:IL-10Rβ
7772:IL-20Rα
7762:IL-20Rβ
7696:IL-36RA
7241:ALT-803
6354:301–350
6148:251–300
6100:CD240CE
5897:201–250
5581:151–200
5304:101–150
4483:Ser/Thr
4305:IL22RA2
4301:IL22RA1
4272:Type II
4201:IL12RB2
4197:IL12RB1
4180:IL12RB1
4079:β-chain
4048:IL13RA2
4044:IL13RA1
4006:γ-chain
3403:PDBe-KB
3393:UniProt
3358:9244114
3315:1993646
3280:1693645
3148:7755894
3127:Bibcode
3091:4866556
3074:: 675.
3040:7942057
2906:6306427
2841:8716671
2789:3594590
2618:6111364
2517:6099181
2374:2805446
2256:6628508
2154:3925551
2134:Bibcode
2126:Science
1972:Ensembl
1951:Ensembl
1801:sIL-2Rα
1753:sIL-2Rα
1731:sIL-2Rα
1715:sIL-2Rα
1687:sIL-2Rα
1334:myeloid
1322:B cells
1302:mammals
1243:called
1237:protein
967:UniProt
922:Ensembl
861:Species
840:QuickGO
408:pattern
266:10p15.1
134:Aliases
7732:Others
7705:Others
7657:IL1RL2
7636:IL1RL1
7373:IL18BP
6644:IL-1RA
6361:CD300A
6320:CDw293
6105:CD240D
5966:CD213a
5944:CDw210
5909:CD202b
5883:CDw199
5878:CDw198
5532:CD140b
4964:51–100
4502:family
4497:TGFBR2
4492:TGFBR1
4446:IL17RE
4441:IL17RD
4436:IL17RC
4431:IL17RB
4426:IL17RA
4403:IL18R1
4356:IFNGR2
4352:IFNGR1
4343:IFNAR2
4339:IFNAR1
4318:IL20RB
4314:IL20RA
4293:IL10RB
4289:IL10RA
4223:other
4153:IL27RA
4144:IL11RA
4112:GM-CSF
3997:Type I
3880:TweakR
3712:CMKLR1
3690:CX3CR1
3398:P01589
3356:
3348:
3313:
3278:
3232:
3224:
3155:
3145:
3098:
3088:
3047:
3037:
2998:
2957:
2913:
2903:
2848:
2838:
2796:
2786:
2742:
2701:
2660:
2625:
2615:
2576:
2568:
2524:
2514:
2425:
2417:
2381:
2371:
2332:
2263:
2253:
2152:
2109:
2101:
2061:
2053:
1899:IL-2Rα
1852:IL-2Rα
1833:IL-2Rα
1821:IL-2Rα
1815:Since
1793:stroke
1777:IL-2Rα
1695:cancer
1677:gene.
1556:ligand
1265:genome
1253:IDDM10
1143:search
1141:PubMed
1000:P01590
981:P01589
877:Entrez
579:BioGPS
521:zygote
517:thymus
491:tonsil
463:spleen
158:147730
7615:IL-31
7575:IL-28
7554:IL-27
7498:IL-23
7466:IL-22
7425:IL-21
7383:IL-20
7337:IL-18
7256:IL-17
7230:IL-15
7174:IL-13
7133:IL-12
7107:IL-11
7081:IL-10
6541:CD350
6536:CD349
6531:CD344
6526:CD340
6521:CD339
6516:CD338
6511:CD337
6506:CD336
6501:CD335
6496:CD334
6491:CD333
6486:CD332
6481:CD331
6476:CD329
6471:CD328
6466:CD327
6461:CD326
6456:CD325
6451:CD324
6446:CD322
6441:CD321
6436:CD320
6431:CD318
6426:CD317
6421:CD316
6416:CD315
6411:CD314
6406:CD312
6401:CD309
6396:CD307
6391:CD306
6386:CD305
6381:CD304
6376:CD303
6371:CD302
6366:CD301
6345:CD299
6340:CD298
6335:CD297
6330:CD295
6325:CD294
6315:CD292
6310:CD290
6305:CD289
6300:CD288
6295:CD286
6290:CD284
6285:CD283
6280:CD282
6275:CD281
6270:CD280
6265:CD279
6260:CD278
6255:CD276
6250:CD275
6245:CD274
6240:CD273
6235:CD272
6230:CD271
6225:CD269
6220:CD268
6215:CD267
6210:CD266
6205:CD265
6200:CD264
6195:CD263
6190:CD262
6185:CD261
6180:CD258
6175:CD257
6170:CD256
6165:CD254
6160:CD253
6155:CD252
6139:CD249
6134:CD248
6130:CD247
6125:CD246
6120:CD244
6115:CD243
6110:CD241
6095:CD239
6090:CD238
6085:CD236
6068:CD235
6063:CD234
6058:CD233
6053:CD230
6048:CD229
6043:CD228
6038:CD227
6033:CD226
6028:CD225
6023:CD224
6018:CD223
6013:CD222
6008:CD221
6003:CD220
5988:CD218
5983:CD217
5961:CD212
5939:CD209
5934:CD208
5929:CD207
5924:CD206
5919:CD205
5914:CD204
5904:CD201
5888:CD200
5873:CD197
5868:CD196
5863:CD195
5858:CD194
5853:CD193
5848:CD192
5843:CD191
5838:CD186
5833:CD185
5828:CD184
5823:CD183
5818:CD182
5813:CD181
5808:CD180
5791:CD179
5786:CD178
5781:CD177
5776:CD174
5754:CD172
5749:CD171
5744:CD170
5739:CD169
5734:CD168
5717:CD167
5712:CD166
5707:CD164
5702:CD163
5697:CD162
5692:CD161
5687:CD160
5670:CD159
5640:CD158
5635:CD157
5613:CD156
5608:CD155
5603:CD154
5598:CD153
5593:CD152
5588:CD151
5572:CD150
5567:CD148
5562:CD147
5557:CD146
5552:CD144
5547:CD143
5542:CD142
5537:CD141
5527:CD138
5522:CD137
5517:CD136
5512:CD135
5507:CD134
5502:CD133
5497:CD132
5492:CD131
5487:CD130
5482:CD129
5477:CD127
5472:CD126
5467:CD125
5462:CD124
5457:CD123
5452:CD122
5435:CD121
5418:CD120
5413:CD119
5408:CD118
5403:CD117
5398:CD116
5393:CD115
5388:CD114
5383:CD113
5378:CD112
5373:CD111
5368:CD110
5363:CD109
5358:CD108
5341:CD107
5336:CD106
5331:CD105
5326:CD104
5321:CD103
5316:CD102
5311:CD101
5295:CD100
4471:CSF1R
4399:IL18R
4392:IL1R2
4387:IL1R1
4323:IL28R
4310:IL20R
4297:IL22R
4285:IL10R
4235:G-CSF
4217:Other
4206:IL23R
4193:IL12R
4170:CNTFR
4135:IL6RA
4122:gp130
4105:IL5RA
4096:IL3RA
4067:IL21R
4057:IL7RA
4040:IL13R
4031:IL15R
4027:IL2RB
4023:IL2RA
3971:EDA2R
3948:21-27
3896:BAFFR
3825:11-20
3813:CD137
3765:CD134
3749:TNFR2
3741:TNFR1
3707:CCBP2
3686:CX3C
3680:Other
3671:CXCR7
3666:CXCR6
3661:CXCR5
3656:CXCR4
3651:CXCR3
3644:CXCR2
3639:CXCR1
3616:CCR10
3576:CCRL2
3566:CCRL1
3544:GPCRs
3354:S2CID
3230:S2CID
3206:(PDF)
3181:(PDF)
3174:(PDF)
2978:Blood
2574:S2CID
2423:S2CID
2233:Cells
2227:IL2RA
2107:S2CID
2059:S2CID
1895:Tregs
1872:IL2RA
1858:with
1817:Tregs
1675:FOXP3
1603:STAT3
1599:STAT1
1595:STAT5
1552:CD132
1548:CD122
1536:mRNAs
1533:IL2RA
1525:IL2RA
1518:IL-15
1514:IL-21
1510:IL-15
1489:IL2RG
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1453:IL2RA
1384:IL2RA
1346:IL2RA
1296:gene
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1280:IL2RA
1261:IL2RA
1257:TCGFR
1245:IL2RA
1209:IL2RG
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1198:IL2RA
1184:The i
910:16184
870:Mouse
865:Human
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541:blood
475:blood
431:Mouse
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270:Start
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166:96549
141:IL2RA
42:IL2RA
34:Cdc25
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7039:here
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7009:IL-7
6928:IL-6
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6765:IL-3
6689:IL-2
6594:IL-1
5290:CD99
5285:CD98
5280:CD97
5275:CD96
5270:CD95
5265:CD94
5260:CD93
5255:CD92
5251:CD91
5246:CD90
5241:CD89
5236:CD88
5231:CD87
5226:CD86
5189:CD85
5184:CD84
5179:CD83
5174:CD82
5169:CD81
5164:CD80
5147:CD79
5142:CD78
5137:CD74
5132:CD73
5127:CD72
5122:CD71
5117:CD70
5112:CD69
5107:CD68
5070:CD66
5048:CD64
5043:CD63
5021:CD62
5016:CD61
5011:CD59
5006:CD58
5001:CD57
4996:CD56
4991:CD55
4986:CD54
4981:CD53
4976:CD52
4971:CD51
4955:CD50
4918:CD49
4913:CD48
4908:CD47
4903:CD46
4898:CD45
4893:CD44
4888:CD43
4861:CD42
4856:CD41
4851:CD40
4846:CD39
4841:CD38
4836:CD37
4831:CD36
4826:CD35
4821:CD34
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4779:CD28
4774:CD27
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4764:CD25
4759:CD24
4754:CD23
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4734:CD19
4729:CD18
4712:CD16
4707:CD15
4702:CD14
4697:CD13
4670:CD11
4665:CD10
4562:1–50
4421:IL17
4335:-α/β
4165:LIFR
4160:OSMR
4101:IL5R
4092:IL3R
4062:IL9R
4053:IL7R
4036:IL4R
4019:IL2R
3928:GITR
3920:BCMA
3912:NGFR
3904:HVEM
3888:TACI
3864:RANK
3856:DcR2
3848:DcR1
3805:CD30
3797:CD27
3789:DcR3
3773:CD40
3757:LTBR
3734:1-10
3700:XCR1
3634:IL-8
3611:CCR9
3606:CCR8
3601:CCR7
3596:CCR6
3591:CCR5
3586:CCR4
3581:CCR3
3571:CCR2
3562:CCR1
3487:2erj
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3391:for
3346:PMID
3311:PMID
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3222:PMID
3153:PMID
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2996:PMID
2955:PMID
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2794:PMID
2740:PMID
2699:PMID
2658:PMID
2623:PMID
2566:PMID
2522:PMID
2415:PMID
2379:PMID
2330:PMID
2261:PMID
2150:PMID
2099:PMID
2051:PMID
1921:and
1903:IL-2
1889:and
1795:and
1767:for
1755:and
1721:and
1709:and
1693:and
1671:IPEX
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1601:and
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