659:
636:
4464:
4119:
4479:
558:
533:
4554:
4164:
4149:
4134:
4494:
4239:
4029:
3894:
4434:
4419:
4389:
4374:
4569:
4539:
4509:
4449:
3999:
3984:
3969:
3954:
4584:
4074:
4059:
4044:
4014:
4254:
3924:
4194:
3939:
4224:
4209:
917:
910:
4524:
4179:
4089:
4284:
4269:
665:
564:
42:
4359:
4344:
4329:
4314:
3909:
4104:
4299:
4404:
1743:
Ccna2 has been found to induce cardiac repair in small-animal models following myocardial infarction. Preclinical trials involving injections of adenovirus which contained the Ccna2 gene into infarcted porcine (pig) hearts has shown to be protective of MI in pig hearts. Ccna2 mediated cardiac repair
1739:
Cyclin A2 (Ccna2) is a key protein involved in the direction of mammalian cardiac myocytes to grow and divide, and has been shown to induce cardiac repair following myocardial infarction. Normally, Ccna2 is silenced postnatally in mammalian cardiac myocytes. Because of this gene silencing, adult
1641:(pRb). After the R point, pRb is phosphorylated and can no longer bind E2F, leading to cyclin A2 transcription. The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. E2F promotes cyclin A2 transcription by de-repressing the promoter.
68:
2831:
Shapiro SD, Ranjan AK, Kawase Y, Cheng RK, Kara RJ, Bhattacharya R, Guzman-Martinez G, Sanz J, Garcia MJ, Chaudhry HW (2014). "Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes".
1744:
showed both a decrease in fibrosis in the peri-infarct tissue and a greater number of cardiomyocytes at the sites of injection. Delivery of Ccna2 into cardiac tissue invokes a regenerative response and markedly enhances cardiac function.
1706:
in human breast cancer cells Loss of cyclin A2 causes high rates of double-strand breaks in DNA. The increase in double-strand breaks is a consequence of defective homologous recombinational repair of the breaks resulting from reduced
1752:
Increased expression of cyclin A2 has been observed in many types of cancer such as breast, cervical, liver, and lung among others. While it is not clear whether increased expression of cyclin A2 is a cause or result of
1726:
During mouse development and aging, cyclin A2 promotes DNA repair, particularly double-strand break repair, in the brain. Also in mice, cyclin A2 was found to be an RNA binding protein that controls the translation of
4463:
4118:
672:
571:
4478:
1599:
Cyclin A2 is synthesized at the onset of S phase and localizes to the nucleus, where the cyclin A2-CDK2 complex is implicated in the initiation and progression of DNA synthesis. Phosphorylation of
3065:
Ohashi R, Gao C, Miyazaki M, Hamazaki K, Tsuji T, Inoue Y, Uemura T, Hirai R, Shimizu N, Namba M (Jan–Feb 2001). "Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas".
4553:
4163:
4148:
4133:
4493:
3678:
Carbonaro-Hall D, Williams R, Wu L, Warburton D, Zeichner-David M, MacDougall M, Tolo V, Hall F (1993). "G1 expression and multistage dynamics of cyclin A in human osteosarcoma cells".
4238:
2973:
Bukholm IR, Bukholm G, Nesland JM (Jul 2001). "Over-expression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas".
4028:
3893:
3245:
Bailly E, Pines J, Hunter T, Bornens M (1992). "Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome".
2667:"Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells"
4433:
4418:
4388:
4373:
1626:
The levels of cyclin A2 are tightly synchronized with the progression of the cell cycle. Transcription initiates in late G1, peaks and plateaus in mid-S, and declines in G2.
4568:
4538:
3769:
Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex".
3430:
Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massagué J, Pavletich NP (1995). "Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex".
2535:
Joaquin M, Bessa M, Saville MK, Watson RJ (November 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107".
2619:
Marti A, Wirbelauer C, Scheffner M, Krek W (May 1999). "Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation".
3018:"Immunohistochemical detection of sex steroid receptors, cyclins, and cyclin-dependent kinases in the normal and neoplastic squamous epithelia of the uterine cervix"
4508:
2408:
Henneke G, Koundrioukoff S, Hübscher U (July 2003). "Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation".
4448:
3998:
3983:
3968:
3953:
4583:
2451:
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (January 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase".
1275:
494:
4073:
4058:
4043:
1256:
3549:"The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E"
3311:
Bandara LR, Adamczewski JP, Hunt T, La
Thangue NB (1991). "Cyclin A and the retinoblastoma gene product complex with a common transcription factor".
4013:
4253:
3923:
4193:
3938:
4223:
4208:
4624:
1864:
4523:
3274:
Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E (1992). "Interaction between human cyclin A and adenovirus E1A-associated p107 protein".
1846:
3356:
Blanquet V, Wang JA, Chenivesse X, Henglein B, Garreau F, Bréchot C, Turleau C (1990). "Assignment of a human cyclin A gene to 4q26-q27".
3034:
3017:
4178:
4088:
3475:
Castro A, Jaumot M, Vergés M, Agell N, Bachs O (1994). "Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells".
4472:: THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE
4283:
4127:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR
1475:
3385:
Wang J, Chenivesse X, Henglein B, Bréchot C (1990). "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma".
4916:
4810:
4268:
1482:
4487:: CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6
3190:
Wang Y, Prives C (Jul 1995). "Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases".
3736:"Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage"
1669:
3873:
2361:"Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase"
1829:
5122:
4856:
65:
3584:"Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase"
1808:
4358:
4343:
4328:
4313:
3908:
3814:
Russo AA, Jeffrey PD, Pavletich NP (1996). "Structural basis of cyclin-dependent kinase activation by phosphorylation".
4617:
2050:"Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor"
4562:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
658:
4172:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
4157:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
4142:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR
3506:"Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1"
2488:"Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1"
1833:
1812:
635:
4502:: MECHANISM OF CDK INHIBITION BY ACTIVE SITE PHOSPHORYLATION: CDK2 Y15P T160P IN COMPLEX WITH CYCLIN A STRUCTURE
5127:
1320:
2263:"Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation"
4103:
1681:
4247:: The structure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
1301:
4610:
557:
532:
474:
4926:
2763:
Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, et al. (September 2016).
1650:
1611:
4037:: CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN
671:
570:
5067:
4770:
3902:: THR 160 PHOSPHORYLATED CDK2 - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR INDIRUBIN-5-SULPHONATE BOUND
664:
563:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
3866:
3627:"Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15"
3094:"Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas"
1593:
1589:
1618:-CDK1 activation which results in chromatin condensation and the breakdown of the nuclear envelope.
461:
1700:
1585:
1581:
482:
4442:: DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
4427:: DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
4397:: DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
4382:: DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
4717:
4577:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
4547:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
1768:. It is also possible that cyclin A2-CDK contributes to tumorigenesis by the phosphorylation of
1458:
1437:
1411:
1390:
1638:
4298:
5049:
4800:
1637:. Absence of cyclin A2 before the R point is due to the E2F inhibition by hypophosphorylated
17:
3859:
3778:
3701:"Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases"
3638:
3439:
3394:
3320:
3283:
3199:
2929:
2776:
2714:
Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, et al. (July 2016).
2312:"Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization"
2168:
546:
502:
8:
2359:
Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998).
4517:: Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
3782:
3642:
3443:
3398:
3324:
3287:
3203:
2933:
2780:
2580:"Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2"
2172:
1968:
1943:
1740:
heart muscle cells cannot divide readily to repair and regenerate after a heart attack.
5062:
4867:
3839:
3802:
3463:
3418:
3344:
3223:
3167:
3143:"Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase"
3142:
3118:
3093:
3047:
2998:
2950:
2917:
2857:
2797:
2764:
2740:
2715:
2691:
2666:
2644:
2560:
2433:
2336:
2311:
2123:
2098:
2074:
2049:
2016:
1981:
1715:
DNA repair proteins. Cyclin A2 mediates the abundance of MRE11 nuclease by binding to
506:
3608:
3583:
3530:
3505:
2512:
2487:
2385:
2360:
2287:
2262:
2025:
2000:
1908:
1883:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
983:
978:
973:
968:
963:
958:
5057:
4457:: CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
4007:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6102
3992:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6086
3977:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6094
3962:: STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU2058
3831:
3794:
3757:
3722:
3687:
3666:
3661:
3626:
3613:
3570:
3535:
3521:
3492:
3455:
3410:
3373:
3369:
3336:
3299:
3262:
3215:
3172:
3123:
3074:
3039:
2990:
2955:
2898:
2849:
2802:
2745:
2696:
2636:
2601:
2552:
2517:
2503:
2468:
2425:
2390:
2341:
2292:
2240:
2196:
2191:
2156:
2128:
2079:
2030:
1973:
1913:
454:
58:
3051:
3002:
2861:
2564:
1757:, it is indicative of prognostic values such as predictions of survival or relapse.
1607:
by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell cycle.
3823:
3806:
3786:
3747:
3712:
3656:
3646:
3603:
3595:
3560:
3525:
3517:
3484:
3467:
3447:
3422:
3402:
3365:
3348:
3328:
3291:
3254:
3227:
3207:
3162:
3154:
3113:
3105:
3029:
2982:
2945:
2937:
2888:
2841:
2792:
2784:
2735:
2727:
2686:
2678:
2648:
2628:
2591:
2544:
2507:
2499:
2460:
2437:
2417:
2380:
2372:
2331:
2323:
2282:
2274:
2230:
2186:
2176:
2118:
2110:
2069:
2061:
2020:
2012:
1963:
1955:
1903:
1895:
751:
682:
626:
581:
486:
4844:
3843:
1760:
Overexpression of cyclin A2 in mammalian cells can result in the delayed onset of
2875:
Woo YJ, Panlilio CM, Cheng RK, Liao GP, Suarez EE, Atluri P, Chaudhry HW (2007).
2845:
1985:
726:
510:
2893:
2876:
1869:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1851:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1610:
Cyclin A2 is involved in the G2/M transition but it cannot independently form a
827:
4592:: REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS
2716:"Cyclin A2 promotes DNA repair in the brain during both development and aging"
2682:
1959:
5116:
4996:
4403:
3752:
3735:
3717:
3700:
3035:
10.1002/(sici)1097-0142(19980501)82:9<1709::aid-cncr18>3.0.co;2-8
2327:
2157:"Structure and cell cycle-regulated transcription of the human cyclin A gene"
1754:
1561:
945:
3295:
2877:"Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2"
2788:
2181:
2114:
2065:
1899:
916:
909:
887:
765:
5018:
4082:: CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P107
3651:
3565:
3548:
3488:
3176:
3078:
2994:
2959:
2902:
2853:
2806:
2749:
2700:
2640:
2605:
2596:
2579:
2556:
2548:
2472:
2464:
2429:
2421:
2278:
2244:
2132:
2083:
1977:
744:
523:
4067:: CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27
4052:: CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53
3835:
3798:
3761:
3726:
3691:
3670:
3617:
3599:
3574:
3539:
3496:
3459:
3414:
3377:
3340:
3303:
3266:
3258:
3219:
3158:
3127:
3043:
2765:"Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation"
2731:
2521:
2394:
2376:
2345:
2296:
2200:
2034:
1917:
1614:(MPF). Recent studies have shown that the cyclin A2-CDK1 complex triggers
1580:
family, whose members regulate cell cycle progression by interacting with
1522:
5039:
5008:
3109:
1365:
1346:
41:
4022:: CDK2/CYCLIN A IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F
3827:
2941:
2486:
Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (December 1993).
1629:
Cyclin A2 transcription is mostly regulated by the transcription factor
1517:
4960:
4633:
4262:: THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
2235:
2218:
1720:
1719:
mRNA. Cyclin A2 mediates the abundance of RAD51 protein by inhibiting
1703:
1166:
regulation of cyclin-dependent protein serine/threonine kinase activity
643:
540:
490:
4602:
3932:: THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
2762:
1882:
Paterlini P, De Mitri MS, Martin C, Münnich A, Bréchot C (July 1991).
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
5083:
5033:
5023:
4706:
4702:
4692:
4688:
4684:
4674:
4670:
4656:
4202:: CYCLIN A BINDING GROOVE INHIBITOR AC-ARG-ARG-LEU-ASN-(M-CL-PHE)-NH2
3947:: PCDK2/CYCLIN A IN COMPLEX WITH MGADP, NITRATE AND PEPTIDE SUBSTRATE
3790:
3451:
3406:
3332:
3211:
2986:
2310:
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (January 1999).
2099:"The roles of cyclin A2, B1, and B2 in early and late mitotic events"
1761:
1615:
1553:
1220:
710:
697:
609:
596:
498:
5088:
5028:
5013:
4982:
4968:
4698:
4680:
4666:
4652:
4232:: CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ASN-(P-F-PHE)-NH2
4217:: CYCLIN A BINDING GROOVE INHIBITOR H-CIT-CIT-LEU-ILE-(P-F-PHE)-NH2
1999:
Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G (March 1992).
1785:
1769:
1765:
1549:
1506:
984:
cyclin-dependent protein serine/threonine kinase regulator activity
5097:
5004:
4977:
4636:
3677:
2632:
2219:"Cyclin-dependent kinases and S phase control in mammalian cells"
1675:
1634:
1565:
1557:
1538:
1332:
1287:
1205:
1201:
4532:: Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor
3310:
2155:
Henglein B, Chenivesse X, Wang J, Eick D, Bréchot C (Jun 1994).
478:
4936:
4852:
4838:
4834:
4830:
4822:
4780:
4775:
4644:
3504:
Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993).
1577:
1490:
1242:
3851:
3355:
1881:
925:
4911:
4906:
4795:
4790:
4785:
4187:: CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ILE-PHE-NH2
3384:
1712:
1708:
4097:: PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
2618:
2407:
2261:
Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H (1994).
2001:"Cyclin A is required at two points in the human cell cycle"
1584:. Cyclin A2 is unique in that it can activate two different
1091:
cellular response to platelet-derived growth factor stimulus
4940:
4931:
4901:
4880:
4818:
4292:: CYCLIN A BINDING GROOVE INHIBITOR ACE-ARG-LYS-LEU-PHE-GLY
3016:
Kanai M, Shiozawa T, Xin L, Nikaido T, Fujii S (May 1998).
2450:
2309:
1998:
1687:
1663:
1657:
1604:
1600:
1545:
3768:
3091:
2713:
2154:
4921:
4885:
4875:
4848:
4826:
4277:: PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
3064:
2534:
1773:
1630:
3733:
3244:
2830:
1086:
cellular response to insulin-like growth factor stimulus
734:
3624:
3503:
3474:
3429:
3015:
2485:
3273:
3813:
2972:
899:
2874:
2577:
1186:
positive regulation of cell population proliferation
3547:Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1993).
2358:
1106:
positive regulation of transcription, DNA-templated
3546:
2756:
1825:
1823:
1821:
1804:
1802:
1800:
1025:cyclin-dependent protein kinase holoenzyme complex
3698:
3092:Volm M, Koomägi R, Mattern J, Stammler G (1997).
2260:
1056:cellular response to luteinizing hormone stimulus
681:
580:
5114:
3734:Poon RY, Jiang W, Toyoshima H, Hunter T (1996).
1884:"A TaqI polymorphism in the human cyclin A gene"
2826:
2824:
2822:
2820:
2818:
2816:
2212:
2210:
1818:
1797:
1071:positive regulation of fibroblast proliferation
29:Protein-coding gene in the species Homo sapiens
3140:
2256:
2254:
2150:
2148:
2146:
2144:
2142:
1937:
1935:
1933:
1931:
1929:
1927:
1830:GRCm38: Ensembl release 89: ENSMUSG00000027715
4618:
3867:
2915:
4367:: STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
4352:: STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529
4337:: STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611
4322:: STRUCTURE OF CDK2/CYCLIN A WITH PNU-292137
3917:: CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
3134:
3058:
2966:
2909:
2868:
2813:
2612:
2578:Rosner M, Hengstschläger M (November 2004).
2571:
2528:
2444:
2401:
2207:
1081:cellular response to organic cyclic compound
3183:
3085:
3009:
2479:
2352:
2303:
2251:
2139:
2096:
2090:
2041:
1944:"Cyclin A in cell cycle control and cancer"
1941:
1924:
1809:GRCh38: Ensembl release 89: ENSG00000145386
4625:
4611:
3874:
3860:
3625:Sebastian B, Kakizuka A, Hunter T (1993).
3581:
3189:
2707:
2660:
2658:
2047:
1992:
1875:
1596:during the transition from G2 to M phase.
4917:Cellular apoptosis susceptibility protein
3751:
3716:
3660:
3650:
3607:
3564:
3529:
3166:
3117:
3033:
2949:
2892:
2796:
2739:
2690:
2664:
2595:
2511:
2384:
2335:
2286:
2234:
2190:
2180:
2122:
2073:
2024:
1967:
1907:
838:fetal liver hematopoietic progenitor cell
1734:
969:cyclin-dependent protein kinase activity
4632:
2655:
2216:
1076:cellular response to estradiol stimulus
14:
5115:
2665:Gu WW, Lin J, Hong XY (October 2017).
1181:regulation of mitotic nuclear division
4606:
3855:
1942:Yam CH, Fung TK, Poon RY (Aug 2002).
1146:G2/M transition of mitotic cell cycle
686:
647:
642:
585:
544:
539:
2048:Fung TK, Ma HT, Poon RY (Mar 2007).
1564:while cyclin A2 is expressed in the
1096:cellular response to leptin stimulus
24:
3237:
2017:10.1002/j.1460-2075.1992.tb05135.x
25:
5139:
4112:: P27(KIP1)/CYCLIN A/CDK2 COMPLEX
3141:den Elzen N, Pines J (Apr 2001).
1541:that in humans is encoded by the
1191:positive regulation of cell cycle
1116:cellular response to nitric oxide
4582:
4567:
4552:
4537:
4522:
4507:
4492:
4477:
4462:
4447:
4432:
4417:
4402:
4387:
4372:
4357:
4342:
4327:
4312:
4297:
4282:
4267:
4252:
4237:
4222:
4207:
4192:
4177:
4162:
4147:
4132:
4117:
4102:
4087:
4072:
4057:
4042:
4027:
4012:
3997:
3982:
3967:
3952:
3937:
3922:
3907:
3892:
3699:Meikrantz W, Schlegel R (1996).
3522:10.1128/JVI.67.12.7641-7647.1993
2504:10.1128/JVI.67.12.7641-7647.1993
2217:Woo RA, Poon RY (Jul–Aug 2003).
1548:. It is one of the two types of
1156:cell cycle G1/S phase transition
915:
908:
670:
663:
657:
634:
569:
562:
556:
531:
40:
3881:
2097:Gong D, Ferrell JE (Sep 2010).
1644:
1126:Ras protein signal transduction
974:protein domain specific binding
2916:Laflamme MA, Murry CE (2011).
1857:
1839:
926:More reference expression data
888:More reference expression data
13:
1:
3477:Biochem. Biophys. Res. Commun
2453:Biochem. Biophys. Res. Commun
1791:
1723:degradation of this protein.
1694:
1621:
1176:regulation of DNA replication
655:
554:
3631:Proc. Natl. Acad. Sci. U.S.A
3370:10.1016/0888-7543(90)90052-V
2846:10.1126/scitranslmed.3007668
2161:Proc. Natl. Acad. Sci. U.S.A
1649:Cyclin A2 has been shown to
1633:and begins in G1, after the
1141:cellular response to cocaine
1136:cellular response to hypoxia
7:
5123:Genes on human chromosome 4
4927:Maturation promoting factor
2894:10.1016/j.jtcvs.2006.07.057
2881:J. Thorac. Cardiovasc. Surg
1779:
1612:maturation promoting factor
1571:
800:stromal cell of endometrium
10:
5144:
5068:Postreplication checkpoint
3582:Lees EM, Harlow E (1993).
1772:or tumor suppressors like
1701:homologous recombinational
808:mucosa of transverse colon
5076:
5048:
4995:
4959:
4950:
4894:
4866:
4809:
4716:
4643:
3887:
2683:10.18632/oncotarget.20412
1960:10.1007/s00018-002-8510-y
1865:"Mouse PubMed Reference:"
1847:"Human PubMed Reference:"
1747:
1576:Cyclin A2 belongs to the
1521:
1516:
1512:
1505:
1489:
1476:Chr 4: 121.82 – 121.82 Mb
1470:
1455:
1451:
1434:
1430:
1423:
1408:
1404:
1387:
1383:
1376:
1363:
1359:
1344:
1340:
1331:
1318:
1314:
1299:
1295:
1286:
1273:
1269:
1254:
1250:
1241:
1226:
1219:
1215:
1199:
1111:animal organ regeneration
944:
940:
923:
907:
898:
885:
834:
825:
772:
763:
733:
725:
721:
704:
691:
654:
633:
624:
620:
603:
590:
553:
530:
521:
517:
472:
469:
459:
452:
447:
84:
79:
62:
57:
52:
48:
39:
34:
3753:10.1074/jbc.271.22.13283
3718:10.1074/jbc.271.17.10205
1161:regulation of cell cycle
1151:protein deubiquitination
3296:10.1126/science.1532458
2789:10.1126/science.aaf7463
2182:10.1073/pnas.91.12.5490
2115:10.1091/mbc.E10-05-0393
2066:10.1091/mbc.E06-12-1092
1483:Chr 3: 36.62 – 36.63 Mb
979:protein kinase activity
465:, CCN1, CCNA, cyclin A2
5050:Cell cycle checkpoints
3652:10.1073/pnas.90.8.3521
3566:10.1101/gad.7.12a.2366
3489:10.1006/bbrc.1994.1814
2597:10.1074/jbc.M405528200
2549:10.1038/sj.onc.1206001
2465:10.1006/bbrc.1999.2007
2422:10.1038/sj.onc.1206606
2328:10.1093/emboj/18.2.396
2279:10.1128/MCB.14.12.8420
1639:retinoblastoma protein
1035:cyclin A2-CDK2 complex
964:protein kinase binding
5128:Cell cycle regulators
5077:Other cellular phases
4801:CDK-activating kinase
3600:10.1128/MCB.13.2.1194
3259:10.1242/jcs.101.3.529
3159:10.1083/jcb.153.1.121
2732:10.18632/aging.100990
2377:10.1128/mcb.18.5.2758
1900:10.1093/nar/19.9.2516
1735:Clinical significance
1061:response to estradiol
866:mandibular prominence
3110:10.1038/bjc.1997.302
2918:"Heart regeneration"
1699:Cyclin A2 regulates
1592:during S phase, and
1556:is expressed during
1066:response to glucagon
862:maxillary prominence
649:Chromosome 3 (mouse)
547:Chromosome 4 (human)
80:List of PDB id codes
53:Available structures
3828:10.1038/nsb0896-696
3783:1996Natur.382..325R
3746:(22): 13283–13291.
3711:(17): 10205–10209.
3643:1993PNAS...90.3521S
3444:1995Natur.376..313J
3399:1990Natur.343..555W
3325:1991Natur.352..249B
3288:1992Sci...255...87F
3204:1995Natur.376...88W
2942:10.1038/nature10147
2934:2011Natur.473..326L
2781:2016Sci...353.1549K
2775:(6307): 1549–1552.
2677:(53): 90842–90851.
2590:(47): 48707–48715.
2173:1994PNAS...91.5490H
1948:Cell. Mol. Life Sci
1051:cochlea development
788:ganglionic eminence
688:3 B|3 17.67 cM
5063:Spindle checkpoint
4868:P53 p63 p73 family
4307:: BOVINE CYCLIN A3
3559:(12A): 2366–2377.
2236:10.4161/cc.2.4.468
1568:of somatic cells.
1321:ENSMUSG00000027715
1171:mitotic cell cycle
1044:Biological process
993:Cellular component
952:Molecular function
5110:
5109:
5106:
5105:
5058:Restriction point
4600:
4599:
3816:Nat. Struct. Biol
3777:(6589): 325–331.
3516:(12): 7641–7647.
3438:(6538): 313–320.
3393:(6258): 555–557.
3319:(6332): 249–251.
3104:(12): 1774–1778.
2928:(7347): 326–335.
2543:(52): 7923–7932.
2498:(12): 7641–7647.
2416:(28): 4301–4313.
2273:(12): 8420–8431.
2167:(12): 5490–5494.
2109:(18): 3149–3161.
1888:Nucleic Acids Res
1532:
1531:
1528:
1527:
1501:
1500:
1466:
1465:
1445:
1444:
1419:
1418:
1398:
1397:
1372:
1371:
1353:
1352:
1327:
1326:
1308:
1307:
1282:
1281:
1263:
1262:
1211:
1210:
1005:female pronucleus
936:
935:
932:
931:
894:
893:
881:
880:
819:
818:
717:
716:
616:
615:
511:CCNA2 - orthologs
443:
442:
439:
438:
63:Ortholog search:
16:(Redirected from
5135:
4957:
4956:
4627:
4620:
4613:
4604:
4603:
4586:
4571:
4556:
4541:
4526:
4511:
4496:
4481:
4466:
4451:
4436:
4421:
4406:
4391:
4376:
4361:
4346:
4331:
4316:
4301:
4286:
4271:
4256:
4241:
4226:
4211:
4196:
4181:
4166:
4151:
4136:
4121:
4106:
4091:
4076:
4061:
4046:
4031:
4016:
4001:
3986:
3971:
3956:
3941:
3926:
3911:
3896:
3876:
3869:
3862:
3853:
3852:
3847:
3810:
3791:10.1038/382325a0
3765:
3755:
3730:
3720:
3695:
3686:(6): 1649–1659.
3674:
3664:
3654:
3637:(8): 3521–3524.
3621:
3611:
3594:(2): 1194–1201.
3578:
3568:
3543:
3533:
3500:
3483:(3): 1072–1078.
3471:
3452:10.1038/376313a0
3426:
3407:10.1038/343555a0
3381:
3352:
3333:10.1038/352249a0
3307:
3270:
3232:
3231:
3212:10.1038/376088a0
3187:
3181:
3180:
3170:
3138:
3132:
3131:
3121:
3089:
3083:
3082:
3062:
3056:
3055:
3037:
3028:(9): 1709–1719.
3013:
3007:
3006:
2987:10.1002/ijc.1311
2970:
2964:
2963:
2953:
2913:
2907:
2906:
2896:
2872:
2866:
2865:
2840:(224): 224ra27.
2828:
2811:
2810:
2800:
2760:
2754:
2753:
2743:
2726:(7): 1540–1570.
2711:
2705:
2704:
2694:
2662:
2653:
2652:
2616:
2610:
2609:
2599:
2575:
2569:
2568:
2532:
2526:
2525:
2515:
2483:
2477:
2476:
2448:
2442:
2441:
2405:
2399:
2398:
2388:
2371:(5): 2758–2767.
2356:
2350:
2349:
2339:
2307:
2301:
2300:
2290:
2258:
2249:
2248:
2238:
2214:
2205:
2204:
2194:
2184:
2152:
2137:
2136:
2126:
2094:
2088:
2087:
2077:
2060:(5): 1861–1873.
2045:
2039:
2038:
2028:
1996:
1990:
1989:
1971:
1954:(8): 1317–1326.
1939:
1922:
1921:
1911:
1879:
1873:
1872:
1861:
1855:
1854:
1843:
1837:
1827:
1816:
1806:
1566:mitotic division
1514:
1513:
1485:
1478:
1461:
1449:
1448:
1440:
1428:
1427:
1424:RefSeq (protein)
1414:
1402:
1401:
1393:
1381:
1380:
1357:
1356:
1338:
1337:
1312:
1311:
1293:
1292:
1267:
1266:
1248:
1247:
1217:
1216:
942:
941:
928:
919:
912:
905:
904:
890:
858:ventricular zone
842:genital tubercle
830:
828:Top expressed in
823:
822:
784:secondary oocyte
776:ventricular zone
768:
766:Top expressed in
761:
760:
740:
739:
723:
722:
713:
700:
689:
674:
667:
661:
650:
638:
622:
621:
612:
599:
588:
573:
566:
560:
549:
535:
519:
518:
513:
464:
457:
434:
77:
76:
71:
50:
49:
44:
32:
31:
21:
5143:
5142:
5138:
5137:
5136:
5134:
5133:
5132:
5113:
5112:
5111:
5102:
5092:
5072:
5044:
4991:
4986:
4972:
4952:
4946:
4890:
4862:
4805:
4712:
4639:
4631:
4601:
4596:
4593:
4587:
4578:
4572:
4563:
4557:
4548:
4542:
4533:
4527:
4518:
4512:
4503:
4497:
4488:
4482:
4473:
4467:
4458:
4452:
4443:
4437:
4428:
4422:
4413:
4407:
4398:
4392:
4383:
4377:
4368:
4362:
4353:
4347:
4338:
4332:
4323:
4317:
4308:
4302:
4293:
4287:
4278:
4272:
4263:
4257:
4248:
4242:
4233:
4227:
4218:
4212:
4203:
4197:
4188:
4182:
4173:
4167:
4158:
4152:
4143:
4137:
4128:
4122:
4113:
4107:
4098:
4092:
4083:
4077:
4068:
4062:
4053:
4047:
4038:
4032:
4023:
4017:
4008:
4002:
3993:
3987:
3978:
3972:
3963:
3957:
3948:
3942:
3933:
3927:
3918:
3912:
3903:
3897:
3883:
3880:
3850:
3588:Mol. Cell. Biol
3282:(5040): 87–90.
3240:
3238:Further reading
3235:
3198:(6535): 88–91.
3188:
3184:
3139:
3135:
3090:
3086:
3073:(1B): 657–662.
3063:
3059:
3014:
3010:
2971:
2967:
2914:
2910:
2873:
2869:
2829:
2814:
2761:
2757:
2712:
2708:
2663:
2656:
2617:
2613:
2576:
2572:
2533:
2529:
2484:
2480:
2449:
2445:
2406:
2402:
2365:Mol. Cell. Biol
2357:
2353:
2308:
2304:
2267:Mol. Cell. Biol
2259:
2252:
2215:
2208:
2153:
2140:
2103:Mol. Biol. Cell
2095:
2091:
2054:Mol. Biol. Cell
2046:
2042:
1997:
1993:
1940:
1925:
1880:
1876:
1863:
1862:
1858:
1845:
1844:
1840:
1828:
1819:
1807:
1798:
1794:
1782:
1750:
1737:
1697:
1647:
1624:
1574:
1523:View/Edit Mouse
1518:View/Edit Human
1481:
1474:
1471:Location (UCSC)
1457:
1436:
1410:
1389:
1302:ENSG00000145386
1195:
1039:
1010:male pronucleus
988:
959:protein binding
924:
914:
913:
886:
877:
872:
868:
864:
860:
856:
852:
848:
844:
840:
826:
815:
812:trabecular bone
810:
806:
802:
798:
794:
790:
786:
782:
778:
764:
708:
695:
687:
677:
676:
675:
668:
648:
625:Gene location (
607:
594:
586:
576:
575:
574:
567:
545:
522:Gene location (
473:
460:
453:
86:
64:
30:
23:
22:
15:
12:
11:
5:
5141:
5131:
5130:
5125:
5108:
5107:
5104:
5103:
5101:
5100:
5095:
5090:
5086:
5080:
5078:
5074:
5073:
5071:
5070:
5065:
5060:
5054:
5052:
5046:
5045:
5043:
5042:
5037:
5031:
5026:
5021:
5016:
5011:
5001:
4999:
4993:
4992:
4990:
4989:
4984:
4980:
4975:
4970:
4965:
4963:
4954:
4948:
4947:
4945:
4944:
4934:
4929:
4924:
4919:
4914:
4909:
4904:
4898:
4896:
4892:
4891:
4889:
4888:
4883:
4878:
4872:
4870:
4864:
4863:
4861:
4860:
4842:
4815:
4813:
4807:
4806:
4804:
4803:
4798:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4722:
4720:
4714:
4713:
4711:
4710:
4696:
4678:
4664:
4649:
4647:
4641:
4640:
4630:
4629:
4622:
4615:
4607:
4598:
4597:
4595:
4594:
4588:
4581:
4579:
4573:
4566:
4564:
4558:
4551:
4549:
4543:
4536:
4534:
4528:
4521:
4519:
4513:
4506:
4504:
4498:
4491:
4489:
4483:
4476:
4474:
4468:
4461:
4459:
4453:
4446:
4444:
4438:
4431:
4429:
4423:
4416:
4414:
4408:
4401:
4399:
4393:
4386:
4384:
4378:
4371:
4369:
4363:
4356:
4354:
4348:
4341:
4339:
4333:
4326:
4324:
4318:
4311:
4309:
4303:
4296:
4294:
4288:
4281:
4279:
4273:
4266:
4264:
4258:
4251:
4249:
4243:
4236:
4234:
4228:
4221:
4219:
4213:
4206:
4204:
4198:
4191:
4189:
4183:
4176:
4174:
4168:
4161:
4159:
4153:
4146:
4144:
4138:
4131:
4129:
4123:
4116:
4114:
4108:
4101:
4099:
4093:
4086:
4084:
4078:
4071:
4069:
4063:
4056:
4054:
4048:
4041:
4039:
4033:
4026:
4024:
4018:
4011:
4009:
4003:
3996:
3994:
3988:
3981:
3979:
3973:
3966:
3964:
3958:
3951:
3949:
3943:
3936:
3934:
3928:
3921:
3919:
3913:
3906:
3904:
3898:
3891:
3888:
3885:
3884:
3879:
3878:
3871:
3864:
3856:
3849:
3848:
3822:(8): 696–700.
3811:
3766:
3731:
3696:
3675:
3622:
3579:
3544:
3501:
3472:
3427:
3382:
3364:(3): 595–597.
3353:
3308:
3271:
3253:(3): 529–545.
3241:
3239:
3236:
3234:
3233:
3182:
3153:(1): 121–136.
3133:
3084:
3067:Anticancer Res
3057:
3008:
2981:(2): 283–287.
2975:Int. J. Cancer
2965:
2908:
2887:(4): 927–933.
2867:
2834:Sci Transl Med
2812:
2755:
2706:
2654:
2621:Nat. Cell Biol
2611:
2570:
2527:
2478:
2459:(3): 947–952.
2443:
2400:
2351:
2322:(2): 396–410.
2302:
2250:
2229:(4): 316–324.
2206:
2138:
2089:
2040:
2011:(3): 961–971.
1991:
1923:
1874:
1856:
1838:
1817:
1795:
1793:
1790:
1789:
1788:
1781:
1778:
1749:
1746:
1736:
1733:
1696:
1693:
1692:
1691:
1685:
1679:
1673:
1667:
1661:
1646:
1643:
1623:
1620:
1573:
1570:
1530:
1529:
1526:
1525:
1520:
1510:
1509:
1503:
1502:
1499:
1498:
1496:
1494:
1487:
1486:
1479:
1472:
1468:
1467:
1464:
1463:
1453:
1452:
1446:
1443:
1442:
1432:
1431:
1425:
1421:
1420:
1417:
1416:
1406:
1405:
1399:
1396:
1395:
1385:
1384:
1378:
1374:
1373:
1370:
1369:
1361:
1360:
1354:
1351:
1350:
1342:
1341:
1335:
1329:
1328:
1325:
1324:
1316:
1315:
1309:
1306:
1305:
1297:
1296:
1290:
1284:
1283:
1280:
1279:
1271:
1270:
1264:
1261:
1260:
1252:
1251:
1245:
1239:
1238:
1233:
1228:
1224:
1223:
1213:
1212:
1209:
1208:
1197:
1196:
1194:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1047:
1045:
1041:
1040:
1038:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
996:
994:
990:
989:
987:
986:
981:
976:
971:
966:
961:
955:
953:
949:
948:
938:
937:
934:
933:
930:
929:
921:
920:
902:
896:
895:
892:
891:
883:
882:
879:
878:
876:
875:
871:
867:
863:
859:
855:
851:
847:
846:tail of embryo
843:
839:
835:
832:
831:
820:
817:
816:
814:
813:
809:
805:
801:
797:
793:
789:
785:
781:
777:
773:
770:
769:
757:
756:
748:
737:
731:
730:
727:RNA expression
719:
718:
715:
714:
706:
702:
701:
693:
690:
685:
679:
678:
669:
662:
656:
652:
651:
646:
640:
639:
631:
630:
618:
617:
614:
613:
605:
601:
600:
592:
589:
584:
578:
577:
568:
561:
555:
551:
550:
543:
537:
536:
528:
527:
515:
514:
471:
467:
466:
458:
450:
449:
445:
444:
441:
440:
437:
436:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
9:
6:
4:
3:
2:
5140:
5129:
5126:
5124:
5121:
5120:
5118:
5099:
5096:
5094:
5087:
5085:
5082:
5081:
5079:
5075:
5069:
5066:
5064:
5061:
5059:
5056:
5055:
5053:
5051:
5047:
5041:
5038:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5006:
5003:
5002:
5000:
4998:
4994:
4988:
4981:
4979:
4976:
4974:
4967:
4966:
4964:
4962:
4958:
4955:
4949:
4942:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4899:
4897:
4893:
4887:
4884:
4882:
4879:
4877:
4874:
4873:
4871:
4869:
4865:
4858:
4854:
4850:
4846:
4843:
4840:
4836:
4832:
4828:
4824:
4820:
4817:
4816:
4814:
4812:
4811:CDK inhibitor
4808:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4723:
4721:
4719:
4715:
4708:
4704:
4700:
4697:
4694:
4690:
4686:
4682:
4679:
4676:
4672:
4668:
4665:
4662:
4658:
4654:
4651:
4650:
4648:
4646:
4642:
4638:
4635:
4628:
4623:
4621:
4616:
4614:
4609:
4608:
4605:
4591:
4585:
4580:
4576:
4570:
4565:
4561:
4555:
4550:
4546:
4540:
4535:
4531:
4525:
4520:
4516:
4510:
4505:
4501:
4495:
4490:
4486:
4480:
4475:
4471:
4465:
4460:
4456:
4450:
4445:
4441:
4435:
4430:
4426:
4420:
4415:
4411:
4405:
4400:
4396:
4390:
4385:
4381:
4375:
4370:
4366:
4360:
4355:
4351:
4345:
4340:
4336:
4330:
4325:
4321:
4315:
4310:
4306:
4300:
4295:
4291:
4285:
4280:
4276:
4270:
4265:
4261:
4255:
4250:
4246:
4240:
4235:
4231:
4225:
4220:
4216:
4210:
4205:
4201:
4195:
4190:
4186:
4180:
4175:
4171:
4165:
4160:
4156:
4150:
4145:
4141:
4135:
4130:
4126:
4120:
4115:
4111:
4105:
4100:
4096:
4090:
4085:
4081:
4075:
4070:
4066:
4060:
4055:
4051:
4045:
4040:
4036:
4030:
4025:
4021:
4015:
4010:
4006:
4000:
3995:
3991:
3985:
3980:
3976:
3970:
3965:
3961:
3955:
3950:
3946:
3940:
3935:
3931:
3925:
3920:
3916:
3910:
3905:
3901:
3895:
3890:
3889:
3886:
3877:
3872:
3870:
3865:
3863:
3858:
3857:
3854:
3845:
3841:
3837:
3833:
3829:
3825:
3821:
3817:
3812:
3808:
3804:
3800:
3796:
3792:
3788:
3784:
3780:
3776:
3772:
3767:
3763:
3759:
3754:
3749:
3745:
3741:
3740:J. Biol. Chem
3737:
3732:
3728:
3724:
3719:
3714:
3710:
3706:
3705:J. Biol. Chem
3702:
3697:
3693:
3689:
3685:
3681:
3676:
3672:
3668:
3663:
3658:
3653:
3648:
3644:
3640:
3636:
3632:
3628:
3623:
3619:
3615:
3610:
3605:
3601:
3597:
3593:
3589:
3585:
3580:
3576:
3572:
3567:
3562:
3558:
3554:
3550:
3545:
3541:
3537:
3532:
3527:
3523:
3519:
3515:
3511:
3507:
3502:
3498:
3494:
3490:
3486:
3482:
3478:
3473:
3469:
3465:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3433:
3428:
3424:
3420:
3416:
3412:
3408:
3404:
3400:
3396:
3392:
3388:
3383:
3379:
3375:
3371:
3367:
3363:
3359:
3354:
3350:
3346:
3342:
3338:
3334:
3330:
3326:
3322:
3318:
3314:
3309:
3305:
3301:
3297:
3293:
3289:
3285:
3281:
3277:
3272:
3268:
3264:
3260:
3256:
3252:
3248:
3243:
3242:
3229:
3225:
3221:
3217:
3213:
3209:
3205:
3201:
3197:
3193:
3186:
3178:
3174:
3169:
3164:
3160:
3156:
3152:
3148:
3144:
3137:
3129:
3125:
3120:
3115:
3111:
3107:
3103:
3099:
3098:Br. J. Cancer
3095:
3088:
3080:
3076:
3072:
3068:
3061:
3053:
3049:
3045:
3041:
3036:
3031:
3027:
3023:
3019:
3012:
3004:
3000:
2996:
2992:
2988:
2984:
2980:
2976:
2969:
2961:
2957:
2952:
2947:
2943:
2939:
2935:
2931:
2927:
2923:
2919:
2912:
2904:
2900:
2895:
2890:
2886:
2882:
2878:
2871:
2863:
2859:
2855:
2851:
2847:
2843:
2839:
2835:
2827:
2825:
2823:
2821:
2819:
2817:
2808:
2804:
2799:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2759:
2751:
2747:
2742:
2737:
2733:
2729:
2725:
2721:
2717:
2710:
2702:
2698:
2693:
2688:
2684:
2680:
2676:
2672:
2668:
2661:
2659:
2650:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2615:
2607:
2603:
2598:
2593:
2589:
2585:
2584:J. Biol. Chem
2581:
2574:
2566:
2562:
2558:
2554:
2550:
2546:
2542:
2538:
2531:
2523:
2519:
2514:
2509:
2505:
2501:
2497:
2493:
2489:
2482:
2474:
2470:
2466:
2462:
2458:
2454:
2447:
2439:
2435:
2431:
2427:
2423:
2419:
2415:
2411:
2404:
2396:
2392:
2387:
2382:
2378:
2374:
2370:
2366:
2362:
2355:
2347:
2343:
2338:
2333:
2329:
2325:
2321:
2317:
2313:
2306:
2298:
2294:
2289:
2284:
2280:
2276:
2272:
2268:
2264:
2257:
2255:
2246:
2242:
2237:
2232:
2228:
2224:
2220:
2213:
2211:
2202:
2198:
2193:
2188:
2183:
2178:
2174:
2170:
2166:
2162:
2158:
2151:
2149:
2147:
2145:
2143:
2134:
2130:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2093:
2085:
2081:
2076:
2071:
2067:
2063:
2059:
2055:
2051:
2044:
2036:
2032:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1995:
1987:
1983:
1979:
1975:
1970:
1965:
1961:
1957:
1953:
1949:
1945:
1938:
1936:
1934:
1932:
1930:
1928:
1919:
1915:
1910:
1905:
1901:
1897:
1893:
1889:
1885:
1878:
1870:
1866:
1860:
1852:
1848:
1842:
1835:
1831:
1826:
1824:
1822:
1814:
1810:
1805:
1803:
1801:
1796:
1787:
1784:
1783:
1777:
1775:
1771:
1767:
1763:
1758:
1756:
1755:tumorigenesis
1745:
1741:
1732:
1730:
1724:
1722:
1718:
1714:
1710:
1705:
1702:
1689:
1686:
1683:
1680:
1677:
1674:
1671:
1668:
1665:
1662:
1659:
1656:
1655:
1654:
1652:
1642:
1640:
1636:
1632:
1627:
1619:
1617:
1613:
1608:
1606:
1602:
1597:
1595:
1591:
1587:
1583:
1579:
1569:
1567:
1563:
1562:embryogenesis
1559:
1555:
1551:
1547:
1544:
1540:
1536:
1524:
1519:
1515:
1511:
1508:
1504:
1497:
1495:
1492:
1488:
1484:
1480:
1477:
1473:
1469:
1462:
1460:
1454:
1450:
1447:
1441:
1439:
1433:
1429:
1426:
1422:
1415:
1413:
1407:
1403:
1400:
1394:
1392:
1386:
1382:
1379:
1377:RefSeq (mRNA)
1375:
1368:
1367:
1362:
1358:
1355:
1349:
1348:
1343:
1339:
1336:
1334:
1330:
1323:
1322:
1317:
1313:
1310:
1304:
1303:
1298:
1294:
1291:
1289:
1285:
1278:
1277:
1272:
1268:
1265:
1259:
1258:
1253:
1249:
1246:
1244:
1240:
1237:
1234:
1232:
1229:
1225:
1222:
1218:
1214:
1207:
1203:
1198:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1131:viral process
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1101:cell division
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1048:
1046:
1043:
1042:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
997:
995:
992:
991:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
956:
954:
951:
950:
947:
946:Gene ontology
943:
939:
927:
922:
918:
911:
906:
903:
901:
897:
889:
884:
873:
869:
865:
861:
857:
853:
849:
845:
841:
837:
836:
833:
829:
824:
821:
811:
807:
803:
799:
795:
791:
787:
783:
779:
775:
774:
771:
767:
762:
759:
758:
755:
753:
749:
747:
746:
742:
741:
738:
736:
732:
728:
724:
720:
712:
707:
703:
699:
694:
684:
680:
673:
666:
660:
653:
645:
641:
637:
632:
628:
623:
619:
611:
606:
602:
598:
593:
583:
579:
572:
565:
559:
552:
548:
542:
538:
534:
529:
525:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
468:
463:
456:
451:
446:
435:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
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3250:
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3195:
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3147:J. Cell Biol
3146:
3136:
3101:
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3011:
2978:
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2837:
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2772:
2768:
2758:
2723:
2719:
2709:
2674:
2670:
2633:10.1038/8984
2627:(1): 14–19.
2624:
2620:
2614:
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2540:
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2530:
2495:
2491:
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2413:
2409:
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2226:
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2160:
2106:
2102:
2092:
2057:
2053:
2043:
2008:
2004:
1994:
1951:
1947:
1891:
1887:
1877:
1868:
1859:
1850:
1841:
1770:oncoproteins
1759:
1751:
1742:
1738:
1728:
1725:
1716:
1698:
1648:
1645:Interactions
1628:
1625:
1609:
1598:
1575:
1542:
1534:
1533:
1456:
1435:
1409:
1388:
1364:
1345:
1319:
1300:
1274:
1255:
1235:
1230:
750:
743:
608:121,823,883
595:121,816,444
470:External IDs
85:
26:
5040:Cytokinesis
5009:Preprophase
4953:checkpoints
3882:PDB gallery
3247:J. Cell Sci
1894:(9): 2516.
1588:; it binds
1586:CDK kinases
1582:CDK kinases
1015:nucleoplasm
850:Paneth cell
796:bone marrow
709:36,626,299
696:36,619,014
448:Identifiers
5117:Categories
4961:Interphase
4951:Phases and
4634:Cell cycle
2671:Oncotarget
2223:Cell Cycle
1836:, May 2017
1815:, May 2017
1792:References
1721:proteasome
1704:DNA repair
1695:DNA Repair
1622:Regulation
1121:cell cycle
754:(ortholog)
491:HomoloGene
5084:Apoptosis
5034:Telophase
5024:Metaphase
4819:INK4a/ARF
3553:Genes Dev
1762:metaphase
1616:cyclin B1
1554:cyclin A1
1535:Cyclin-A2
1459:NP_033958
1438:NP_001228
1412:NM_009828
1391:NM_001237
1221:Orthologs
1000:cytoplasm
499:GeneCards
5029:Anaphase
5014:Prophase
4637:proteins
3680:Oncogene
3510:J. Virol
3358:Genomics
3177:11285279
3079:11299822
3052:46236286
3003:10543682
2995:11410878
2960:21593865
2903:17382628
2862:20386712
2854:24553388
2807:27708105
2750:27425845
2701:29207607
2641:10559858
2606:15355997
2565:21761703
2557:12439743
2537:Oncogene
2492:J. Virol
2473:10673397
2430:12853968
2410:Oncogene
2245:12851482
2133:20660152
2084:17344473
1978:12363035
1969:11337442
1832:–
1811:–
1786:Cyclin A
1780:See also
1766:anaphase
1651:interact
1572:Function
1550:cyclin A
1507:Wikidata
1200:Sources:
874:epiblast
5098:Meiosis
5005:Mitosis
4997:M phase
4978:S phase
4845:cip/kip
3836:8756328
3807:4284942
3799:8684460
3779:Bibcode
3762:8662825
3727:8626584
3692:8502485
3671:8475101
3639:Bibcode
3618:8423786
3575:8253383
3540:8230483
3497:8024548
3468:4361179
3460:7630397
3440:Bibcode
3423:4269638
3415:1967822
3395:Bibcode
3378:1962755
3349:1019851
3341:1830372
3321:Bibcode
3304:1532458
3284:Bibcode
3276:Science
3267:1387877
3228:4240439
3220:7596441
3200:Bibcode
3168:2185531
3128:9192980
3119:2223613
3044:9576293
2951:4091722
2930:Bibcode
2798:5109925
2777:Bibcode
2769:Science
2741:4993346
2692:5710888
2649:8884226
2522:8230483
2438:5787920
2395:9566895
2346:9889196
2337:1171134
2297:7969176
2201:8202514
2169:Bibcode
2124:2938381
2075:1855023
2035:1312467
1918:1675006
1834:Ensembl
1813:Ensembl
1676:ITGB3BP
1635:R point
1558:meiosis
1539:protein
1333:UniProt
1288:Ensembl
1227:Species
1206:QuickGO
1030:cytosol
1020:nucleus
729:pattern
455:Aliases
4937:Cullin
4823:p14arf
4645:Cyclin
3844:383015
3842:
3834:
3805:
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3771:Nature
3760:
3725:
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3609:359004
3606:
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3531:238233
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3265:
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3192:Nature
3175:
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3022:Cancer
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2860:
2852:
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2288:359381
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2243:
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2131:
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2082:
2072:
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2026:556537
2023:
2005:EMBO J
1984:
1976:
1966:
1916:
1909:329485
1906:
1748:Cancer
1731:mRNA.
1684:, and
1653:with:
1578:cyclin
1493:search
1491:PubMed
1366:P51943
1347:P20248
1243:Entrez
900:BioGPS
870:ureter
854:somite
804:rectum
780:oocyte
487:108069
479:123835
5093:phase
4987:phase
4973:phase
4912:Cdc42
4907:Cdc25
4895:Other
4677:, B3)
3840:S2CID
3803:S2CID
3662:46332
3464:S2CID
3419:S2CID
3345:S2CID
3224:S2CID
3048:S2CID
2999:S2CID
2858:S2CID
2720:Aging
2645:S2CID
2561:S2CID
2434:S2CID
2192:44021
1986:97398
1982:S2CID
1729:Mre11
1717:Mre11
1713:RAD51
1709:MRE11
1543:CCNA2
1537:is a
1276:12428
1236:Mouse
1231:Human
1202:Amigo
792:gonad
752:Mouse
745:Human
692:Start
627:Mouse
591:Start
524:Human
503:CCNA2
495:55562
462:CCNA2
35:CCNA2
18:CCNA2
4941:CUL7
4902:Cdc2
4590:2uue
4575:2iw9
4560:2iw8
4545:2iw6
4530:2i40
4515:2g9x
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4140:1oi9
4125:1ogu
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3795:PMID
3758:PMID
3723:PMID
3688:PMID
3667:PMID
3614:PMID
3571:PMID
3536:PMID
3493:PMID
3456:PMID
3411:PMID
3374:PMID
3337:PMID
3300:PMID
3263:PMID
3216:PMID
3173:PMID
3124:PMID
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2991:PMID
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2850:PMID
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2469:PMID
2426:PMID
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2342:PMID
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2241:PMID
2197:PMID
2129:PMID
2080:PMID
2031:PMID
1974:PMID
1914:PMID
1764:and
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1682:RBL1
1670:FEN1
1664:E2F1
1658:CDC6
1605:MCM4
1603:and
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1594:CDK1
1590:CDK2
1560:and
1546:gene
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587:4q27
582:Band
541:Chr.
475:OMIM
432:5IF1
428:5CYI
424:4FX3
420:4EOS
416:4EOR
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400:4EON
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392:4EOL
388:4EOK
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340:4BCK
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332:3EOC
328:3EJ1
324:3EID
320:2X1N
316:2WXV
312:2WPA
308:2WMB
304:2WMA
300:2WIP
296:2WIH
292:2WHB
288:2WFY
284:2WEV
280:2V22
276:2UZL
272:2UZE
268:2UZD
264:2UZB
260:2UUE
256:2IW9
252:2IW8
248:2IW6
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