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The signs of BPDME are first noticed in cattle aged 5–8 months, and include a weaving gait, along with weakness and lack of voluntary coordination of the muscles of the hind limbs (known as
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Kunz, E; Rothammer, S; Pausch, H; Schwarzenbacher, H; Seefried, FR; Matiasek, K; Seichter, D; Russ, I; Fries, R; Medugorac, I (18 March 2016).
52:). Signs progressively worsen, and by 18–36 months of age, the animal is unable to rise. Affected animals are euthanized for welfare reasons.
71:"Bovine Progressive Degenerative Myeloencephalopathy (Weaver Syndrome) in Brown Swiss Cattle in Canada: A Literature Review and Case Report"
45:. It is known as 'weaver syndrome' because of the animals' 'weaving' gait while walking. BPDME is a genetic autosomal recessive disorder.
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117:"Confirmation of a non-synonymous SNP in PNPLA8 as a candidate causal mutation for Weaver syndrome in Brown Swiss cattle"
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Divers, Thomas J.; Peek, Simon F., eds. (2008). "Degenerative myeloencephalopathy of Brown Swiss Cattle".
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This article is about a disease in cattle. For the human disease, see
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174:(5th ed.). St. Louis, Missouri: Elsevier/Saunders. p.
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John D. Baird; Ulla M. Sarmiento; Parvathi K. Basrur (1988).
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Lorenz, Michael D.; Coates, Joan R.; Kent, Marc (2011).
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Bovine progressive degenerative myeloencephalopathy
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