247:
224:
146:
121:
512:
505:
498:
253:
152:
1087:
the mitotic spindle checkpoint complex which operates as a feedback-response. If there is a signal of a defect in the attachment, mitosis will be stopped to ensure that all chromosomes have an amphitelic binding to spindles. After the error is corrected, the cell will proceed to anaphase. The complex of proteins which regulate the cell arrest are
1245:
Structural and sequence analysis indicated the existence of three conserved regions that are referred to as WD40 repeats. Mutation of one of these motifs has indicated an impaired ability of Bub3 to interact with Mad2, Mad3, and Cdc20. The structural data suggested that Bub3 acts as a platform that
1086:
Bub3 is a crucial component in the formation of the mitotic spindle assembly complex, which forms a complex with other important proteins. For correct segregation of the cells it is necessary for all mitotic spindles to attach correctly to the kinetochore of each chromosome. This is controlled by
1073:
to achieve biorientation. In directing the kinetochore-microtubule interaction, this ensures the proper (and consequently, bioriented) attachment of the chromosomes prior to anaphase. Bub3 and its related proteins that form the
Spindle Assembly Checkpoint (SAC) inhibit the action of the
1168:
strands that have been organized around a tapered channel. Mutation data suggest several important surfaces of interaction for the formation of the SAC, particularly the conserved tryptophans (in blades 1 and 3) and the conserved VAVE sequences in blade 5.
1127:
interact with the Mad2-Cdc20 complex to inhibit the APC, thus inhibiting the formation of active APC. Bub3 binds constitutively to BubR1; in this arrangement, Bub3 acts as a key component of the SAC in the formation of an inhibitory complex.
2398:"Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells"
1238:
When the SAC is activated, the production of the Bub3-Cdc20 complex is activated. After kinetochore attachment is complete, the spindle checkpoint complexes (including the BubR1-Bub3) experience a decrease in concentration.
1136:
are also stabilized before the anaphase transition by the unattached kinetochores. The stabilization of cyclin and securin prevent the degradation that would lead to the irreversible and fast separation of the
260:
159:
2175:
Saffery R, Irvine DV, Griffiths B, Kalitsis P, Choo KH (October 2000). "Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes".
1265:
Another function of BUB3 is to promote correct kinetochore-microtubule (K-MT) attachments when the spindle-assembly checkpoint is active. It plays a role in the localization of kinetochore of BUB1.
1254:
BUB3 forms a complex with BUB1 (BUB1/BUB3 complex) to inhibit the anaphase-promoting complex or cyclosome (APC/C) as soon as the spindle-assembly checkpoint is activated. BUB3 also phosphorylates:
1230:
The components that are essential for the spindle assembly checkpoint in yeast have been determined to be Bub1, Bub3, Mad1, Mad2, Mad3, and the increasingly important Mps1 (a protein kinase).
29:
1183:, Rae1 has more promiscuous binding as it binds both the nuclear pore complex and Bub1. This indicates a similarity in interaction of Bub3 and Rae1 with Bub1.
1179:
protein family, shows high sequence conservation with that of Bub3. Both bind to Gle2p-binding-sequence (GLEBS) motifs; while Bub3 specifically binds Mad3 and
2213:
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS (April 2001). "A role for the
Adenomatous Polyposis Coli protein in chromosome segregation".
1061:; though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of
765:
746:
82:
1376:
1358:
2615:
Mendoza S, David H, Gaylord GM, Miller CW (April 2005). "Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes".
2330:"Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc"
1859:
Cayrol C, Cougoule C, Wright M (November 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1".
981:
1553:"Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20"
988:
2687:
1450:
2295:"Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated"
2715:
1478:
1341:
1078:, preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation.
2693:
1320:
1403:"The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase"
1950:"Kinetochore-microtubule interactions "in check" by Bub1, Bub3 and BubR1: The dual task of attaching and signalling"
1160:
The crystal structure of Bub3 indicates a protein of the seven-bladed beta-propeller structure with the presence of
246:
2570:
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics".
2439:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004).
1662:"Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores"
1345:
1324:
223:
2537:"Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint"
1503:"Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis"
810:
2413:
1773:
Larsen NA, Harrison SC (December 2004). "Crystal structure of the spindle assembly checkpoint protein Bub3".
1712:"Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis"
1261:
MAD1L1, which usually interacts with BUB1 and BUBR1, and in turn the BUB1/BUB3 complex interacts with MAD1L1.
145:
120:
791:
2252:"Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2"
1811:"Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2"
1613:"Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1"
62:
1214:(the interaction of which does not require intact kinetochores). Additionally, it has been shown to bind
1144:
The formation of these “inhibitory complexes” and steps feed into a ‘wait’ signal before activation of
1075:
259:
158:
2494:"WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase"
1900:"WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase"
252:
151:
2365:"Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter"
49:
1223:
960:
935:
909:
884:
70:
2492:
Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004).
1898:
Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004).
2646:"The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3"
964:
939:
905:
880:
1221:
Bub3 directs the localization of Bub1 at the kinetochore in order to activate the SAC. In both
1148:; at the stage prior to anaphase, securin inhibits the activity of separase and maintains the
1200:
134:
2099:
Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (June 1999).
2579:
2452:
2049:
1723:
1564:
1149:
90:
8:
2699:
2628:
2583:
2456:
2053:
1727:
1568:
2603:
2523:
2422:
2397:
2364:
2276:
2251:
2238:
2201:
2163:
2135:
2072:
2037:
1929:
1835:
1810:
1746:
1711:
1710:
Li M, Li S, Yuan J, Wang ZB, Sun SC, Schatten H, Sun QY (November 2009). Jin DY (ed.).
1587:
1552:
1551:
Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A (July 2008).
1427:
1402:
1058:
94:
2475:
2440:
2380:
2013:
1872:
1686:
1661:
1629:
1612:
1527:
1502:
1473:. London: Published by New Science Press in association with Oxford University Press.
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
609:
604:
599:
594:
589:
584:
579:
574:
558:
553:
2720:
2667:
2632:
2595:
2558:
2515:
2480:
2427:
2384:
2351:
2316:
2281:
2230:
2193:
2155:
2122:
2077:
2017:
1981:
1921:
1876:
1840:
1790:
1751:
1691:
1660:
Fraschini R, Beretta A, Sironi L, Musacchio A, Lucchini G, Piatti S (December 2001).
1634:
1592:
1532:
1474:
1432:
1138:
42:
2527:
2242:
2205:
1933:
74:
2657:
2624:
2607:
2587:
2548:
2505:
2470:
2460:
2417:
2409:
2376:
2341:
2306:
2271:
2263:
2222:
2185:
2167:
2147:
2112:
2067:
2057:
2009:
1971:
1961:
1911:
1868:
1830:
1822:
1782:
1741:
1731:
1681:
1673:
1624:
1582:
1572:
1522:
1514:
1422:
1414:
339:
270:
214:
169:
2510:
2493:
1916:
1899:
2553:
2536:
2062:
1736:
314:
98:
1451:"Entrez Gene: BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)"
1381:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1363:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2445:
Proceedings of the
National Academy of Sciences of the United States of America
1677:
1557:
Proceedings of the
National Academy of Sciences of the United States of America
415:
2328:
Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH (September 2002).
1786:
1258:
CDC20 (activator) and thereby inhibits the ubiquitin ligase activity of APC/C.
2709:
2363:
Baek WK, Park JW, Lim JH, Suh SI, Suh MH, Gabrielson E, Kwon TK (July 2002).
2346:
2329:
540:
511:
504:
497:
2465:
2136:"Assignment of BUB3 to human chromosome band 10q26 by in situ hybridization"
1577:
1271:
Defects in BUB3 in the cell cycle can contribute to the following diseases:
475:
353:
2671:
2662:
2645:
2636:
2599:
2562:
2519:
2484:
2431:
2388:
2355:
2320:
2311:
2294:
2285:
2234:
2197:
2159:
2126:
2117:
2100:
2081:
2021:
2000:
Yu H (December 2002). "Regulation of APC-Cdc20 by the spindle checkpoint".
1985:
1925:
1880:
1844:
1794:
1755:
1695:
1596:
1536:
1070:
332:
111:
2267:
2189:
1826:
1638:
1436:
1268:
BUB3 serves in oocyte meiosis as the regulator of chromosome segregation.
1242:
Bub3 also acts as a regulator in that it affects binding of Mad3 to Mad2.
1028:
1023:
1966:
1949:
1176:
1161:
1066:
855:
836:
2591:
2036:
Doncic A, Ben-Jacob E, Einav S, Barkai N (August 2009). Khanin R (ed.).
1418:
1518:
1165:
231:
128:
78:
2151:
2101:"Characterization of MAD2B and other mitotic spindle checkpoint genes"
1976:
2226:
710:
298:
285:
197:
184:
86:
53:, BUB3L, hmitotic checkpoint protein, BUB3 mitotic checkpoint protein
2441:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
2438:
1145:
1133:
1062:
1012:
2098:
1129:
1044:
822:
777:
695:
691:
66:
2293:
Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH (July 2002).
1659:
1100:
1092:
996:
732:
520:
28:
2174:
1550:
1211:
1196:
1192:
1124:
1120:
2133:
1227:
and metazoans, Bub3 has been shown to bind BubR1 and Bub1.
1215:
1207:
1180:
1172:
1108:
1104:
1096:
1088:
1051:
2035:
1501:
Kalitsis P, Earle E, Fowler KJ, Choo KH (September 2000).
1114:
2614:
2414:
10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2
2292:
2038:"Reverse engineering of the spindle assembly checkpoint"
322:
2327:
2212:
1500:
2535:
Tang Z, Shu H, Oncel D, Chen S, Yu H (November 2004).
2134:
Kwon TK, Hawkins AL, Griffin CA, Gabrielson E (2000).
1057:
Bub3 is a protein involved with the regulation of the
656:
anaphase-promoting complex-dependent catabolic process
2402:
In Vitro
Cellular & Developmental Biology. Animal
487:
1858:
1119:
At unattached kinetochores, a complex consisting of
2569:
1861:
1246:mediates the interaction of SAC protein complexes.
1337:
1335:
1333:
1316:
1314:
1312:
2491:
2395:
1897:
676:regulation of mitotic cell cycle phase transition
661:attachment of spindle microtubules to kinetochore
269:
168:
2707:
2534:
1947:
1610:
1496:
1494:
1492:
1490:
1468:
1330:
1309:
1175:(an mRNA export factor), another member of the
1164:, with each blade formed by four anti-parallel
16:Protein-coding gene in the species Homo sapiens
2643:
2362:
2249:
1808:
1772:
1400:
1342:GRCm38: Ensembl release 89: ENSMUSG00000066979
2250:Sudakin V, Chan GK, Yen TJ (September 2001).
1809:Sudakin V, Chan GK, Yen TJ (September 2001).
1396:
1394:
1392:
1390:
681:ubiquitin-dependent protein catabolic process
666:mitotic spindle assembly checkpoint signaling
1709:
1654:
1652:
1650:
1648:
1487:
1892:
1890:
1321:GRCh38: Ensembl release 89: ENSG00000154473
1206:Bub3 has been shown to form complexes with
2644:Lo KW, Kogoy JM, Pfister KK (April 2007).
1767:
1765:
1611:Fang G, Yu H, Kirschner MW (August 1998).
1387:
2661:
2552:
2509:
2474:
2464:
2421:
2396:Liu L, Amy V, Liu G, McKeehan WL (2003).
2345:
2310:
2275:
2116:
2071:
2061:
1975:
1965:
1915:
1834:
1745:
1735:
1685:
1645:
1628:
1586:
1576:
1526:
1426:
1887:
1464:
1462:
1460:
1249:
1762:
1401:Taylor SS, Ha E, McKeon F (July 1998).
1115:Role in the spindle assembly checkpoint
2708:
2028:
1471:The cell cycle: principles of control
1457:
1443:
1191:BUB3 has been shown to interact with
274:
235:
230:
173:
132:
127:
1948:Logarinho E, Bousbaa H (June 2008).
646:mitotic sister chromatid segregation
636:regulation of chromosome segregation
2650:The Journal of Biological Chemistry
2629:10.1016/j.cancergencyto.2004.08.035
2299:The Journal of Biological Chemistry
1290:osteosarcoma familial breast cancer
671:protein localization to kinetochore
13:
2091:
1999:
14:
2732:
2680:
1059:Spindle Assembly Checkpoint (SAC)
1047:that in humans is encoded by the
2617:Cancer Genetics and Cytogenetics
1076:Anaphase Promoting Complex (APC)
510:
503:
496:
258:
251:
245:
222:
157:
150:
144:
119:
27:
2002:Current Opinion in Cell Biology
1992:
1940:
1851:
1801:
1702:
1603:
1186:
1041:Mitotic checkpoint protein BUB3
2140:Cytogenetics and Cell Genetics
1543:
1369:
1351:
590:chromosome, centromeric region
521:More reference expression data
476:More reference expression data
1:
2511:10.1016/j.febslet.2004.07.089
2381:10.1016/S0378-1119(02)00827-2
2014:10.1016/S0955-0674(02)00382-4
1917:10.1016/j.febslet.2004.07.089
1873:10.1016/S0006-291X(02)02522-6
1630:10.1016/S1097-2765(00)80126-4
1303:
1233:
426:vestibular sensory epithelium
243:
142:
2716:Genes on human chromosome 10
2554:10.1016/j.molcel.2004.09.031
2063:10.1371/journal.pone.0006495
1775:Journal of Molecular Biology
1737:10.1371/journal.pone.0007701
1155:
380:Epithelium of choroid plexus
7:
2256:The Journal of Cell Biology
1815:The Journal of Cell Biology
1407:The Journal of Cell Biology
1081:
10:
2737:
2698:gene details page in the
982:Chr 10: 123.15 – 123.17 Mb
605:mitotic checkpoint complex
450:medial ganglionic eminence
1787:10.1016/j.jmb.2004.09.094
1377:"Mouse PubMed Reference:"
1359:"Human PubMed Reference:"
1027:
1022:
1018:
1011:
995:
989:Chr 7: 131.16 – 131.17 Mb
976:
957:
953:
932:
928:
921:
902:
898:
877:
873:
866:
853:
849:
834:
830:
821:
808:
804:
789:
785:
776:
763:
759:
744:
740:
731:
716:
709:
705:
689:
539:
535:
518:
495:
486:
473:
422:
413:
372:epithelium of nasopharynx
360:
351:
321:
313:
309:
292:
279:
242:
221:
212:
208:
191:
178:
141:
118:
109:
105:
60:
57:
47:
40:
35:
26:
21:
2334:Human Molecular Genetics
1678:10.1093/emboj/20.23.6648
1469:Morgan, David O (2007).
1275:hepatocellular carcinoma
1224:Saccharomyces cerevisiae
2466:10.1073/pnas.0404720101
1578:10.1073/pnas.0804069105
1507:Genes & Development
1293:glioblastoma cervicitis
1095:, BUB3 (this protein),
2663:10.1074/jbc.M611279200
2347:10.1093/hmg/11.19.2319
2312:10.1074/jbc.M200620200
2118:10.1006/geno.1999.5831
626:chromosome segregation
2268:10.1083/jcb.200102093
2190:10.1007/s004390000386
1827:10.1083/jcb.200102093
1296:lung cancer carcinoma
1287:adenomatous polyposis
1250:Clinical significance
1201:Histone deacetylase 2
1065:through direction of
438:mandibular prominence
135:Chromosome 10 (human)
2692:genome location and
1967:10.4161/cc.7.12.6180
1069:localization during
434:maxillary prominence
276:7 F3|7 74.36 cM
237:Chromosome 7 (mouse)
2700:UCSC Genome Browser
2592:10.1038/nature03207
2584:2005Natur.433...77A
2457:2004PNAS..10112130B
2215:Nature Cell Biology
2054:2009PLoSO...4.6495D
1728:2009PLoSO...4.7701L
1569:2008PNAS..105.9181E
1419:10.1083/jcb.142.1.1
454:endocardial cushion
396:ganglionic eminence
376:germinal epithelium
364:gingival epithelium
1519:10.1101/gad.827500
811:ENSMUSG00000066979
619:Biological process
568:Cellular component
547:Molecular function
2152:10.1159/000015547
1480:978-0-87893-508-6
1139:sister chromatids
1038:
1037:
1034:
1033:
1007:
1006:
972:
971:
947:
946:
917:
916:
892:
891:
862:
861:
843:
842:
817:
816:
798:
797:
772:
771:
753:
752:
701:
700:
610:bub1-bub3 complex
559:ubiquitin binding
531:
530:
527:
526:
482:
481:
469:
468:
407:
406:
305:
304:
204:
203:
2728:
2675:
2665:
2656:(15): 11205–12.
2640:
2611:
2566:
2556:
2531:
2513:
2488:
2478:
2468:
2435:
2425:
2392:
2359:
2349:
2324:
2314:
2289:
2279:
2246:
2227:10.1038/35070123
2209:
2171:
2130:
2120:
2086:
2085:
2075:
2065:
2032:
2026:
2025:
1996:
1990:
1989:
1979:
1969:
1944:
1938:
1937:
1919:
1894:
1885:
1884:
1855:
1849:
1848:
1838:
1805:
1799:
1798:
1769:
1760:
1759:
1749:
1739:
1706:
1700:
1699:
1689:
1666:The EMBO Journal
1656:
1643:
1642:
1632:
1607:
1601:
1600:
1590:
1580:
1547:
1541:
1540:
1530:
1498:
1485:
1484:
1466:
1455:
1454:
1447:
1441:
1440:
1430:
1398:
1385:
1384:
1373:
1367:
1366:
1355:
1349:
1339:
1328:
1318:
1020:
1019:
991:
984:
967:
951:
950:
942:
926:
925:
922:RefSeq (protein)
912:
896:
895:
887:
871:
870:
847:
846:
828:
827:
802:
801:
783:
782:
757:
756:
738:
737:
707:
706:
537:
536:
523:
514:
507:
500:
493:
492:
478:
446:stria vascularis
430:primitive streak
418:
416:Top expressed in
411:
410:
384:ventricular zone
356:
354:Top expressed in
349:
348:
328:
327:
311:
310:
301:
288:
277:
262:
255:
249:
238:
226:
210:
209:
200:
187:
176:
161:
154:
148:
137:
123:
107:
106:
101:
99:BUB3 - orthologs
52:
45:
31:
19:
18:
2736:
2735:
2731:
2730:
2729:
2727:
2726:
2725:
2706:
2705:
2683:
2678:
2578:(7021): 77–83.
2451:(33): 12130–5.
2340:(19): 2319–29.
2305:(30): 26921–6.
2094:
2092:Further reading
2089:
2033:
2029:
1997:
1993:
1945:
1941:
1895:
1888:
1856:
1852:
1806:
1802:
1770:
1763:
1707:
1703:
1672:(23): 6648–59.
1657:
1646:
1608:
1604:
1548:
1544:
1513:(18): 2277–82.
1499:
1488:
1481:
1467:
1458:
1449:
1448:
1444:
1399:
1388:
1375:
1374:
1370:
1357:
1356:
1352:
1340:
1331:
1319:
1310:
1306:
1284:cervical cancer
1252:
1236:
1210:-Bub1 and with
1189:
1158:
1117:
1084:
1029:View/Edit Mouse
1024:View/Edit Human
987:
980:
977:Location (UCSC)
963:
959:
938:
934:
908:
904:
883:
879:
792:ENSG00000154473
685:
614:
563:
554:protein binding
519:
509:
508:
502:
501:
474:
465:
460:
456:
452:
448:
444:
440:
436:
432:
428:
414:
403:
398:
394:
390:
386:
382:
378:
374:
370:
366:
352:
296:
283:
275:
265:
264:
263:
256:
236:
213:Gene location (
195:
182:
174:
164:
163:
162:
155:
133:
110:Gene location (
61:
48:
41:
17:
12:
11:
5:
2734:
2724:
2723:
2718:
2704:
2703:
2682:
2681:External links
2679:
2677:
2676:
2641:
2612:
2567:
2541:Molecular Cell
2532:
2489:
2436:
2408:(10): 582–94.
2393:
2360:
2325:
2290:
2247:
2210:
2178:Human Genetics
2172:
2146:(3–4): 202–3.
2131:
2095:
2093:
2090:
2088:
2087:
2027:
1991:
1960:(12): 1763–8.
1939:
1886:
1850:
1800:
1761:
1701:
1644:
1617:Molecular Cell
1602:
1563:(27): 9181–5.
1542:
1486:
1479:
1456:
1442:
1386:
1368:
1350:
1329:
1307:
1305:
1302:
1301:
1300:
1299:Coli polyposis
1297:
1294:
1291:
1288:
1285:
1282:
1279:
1278:gastric cancer
1276:
1263:
1262:
1259:
1251:
1248:
1235:
1232:
1188:
1185:
1157:
1154:
1116:
1113:
1083:
1080:
1036:
1035:
1032:
1031:
1026:
1016:
1015:
1009:
1008:
1005:
1004:
1002:
1000:
993:
992:
985:
978:
974:
973:
970:
969:
955:
954:
948:
945:
944:
930:
929:
923:
919:
918:
915:
914:
900:
899:
893:
890:
889:
875:
874:
868:
864:
863:
860:
859:
851:
850:
844:
841:
840:
832:
831:
825:
819:
818:
815:
814:
806:
805:
799:
796:
795:
787:
786:
780:
774:
773:
770:
769:
761:
760:
754:
751:
750:
742:
741:
735:
729:
728:
723:
718:
714:
713:
703:
702:
699:
698:
687:
686:
684:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
622:
620:
616:
615:
613:
612:
607:
602:
597:
592:
587:
582:
577:
571:
569:
565:
564:
562:
561:
556:
550:
548:
544:
543:
533:
532:
529:
528:
525:
524:
516:
515:
490:
484:
483:
480:
479:
471:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
442:abdominal wall
439:
435:
431:
427:
423:
420:
419:
408:
405:
404:
402:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
358:
357:
345:
344:
336:
325:
319:
318:
315:RNA expression
307:
306:
303:
302:
294:
290:
289:
281:
278:
273:
267:
266:
257:
250:
244:
240:
239:
234:
228:
227:
219:
218:
206:
205:
202:
201:
193:
189:
188:
180:
177:
172:
166:
165:
156:
149:
143:
139:
138:
131:
125:
124:
116:
115:
103:
102:
59:
55:
54:
46:
38:
37:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
2733:
2722:
2719:
2717:
2714:
2713:
2711:
2701:
2697:
2696:
2691:
2690:
2685:
2684:
2673:
2669:
2664:
2659:
2655:
2651:
2647:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2613:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2577:
2573:
2568:
2564:
2560:
2555:
2550:
2547:(3): 387–97.
2546:
2542:
2538:
2533:
2529:
2525:
2521:
2517:
2512:
2507:
2504:(1–3): 23–9.
2503:
2499:
2495:
2490:
2486:
2482:
2477:
2472:
2467:
2462:
2458:
2454:
2450:
2446:
2442:
2437:
2433:
2429:
2424:
2419:
2415:
2411:
2407:
2403:
2399:
2394:
2390:
2386:
2382:
2378:
2375:(1): 117–23.
2374:
2370:
2366:
2361:
2357:
2353:
2348:
2343:
2339:
2335:
2331:
2326:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2291:
2287:
2283:
2278:
2273:
2269:
2265:
2262:(5): 925–36.
2261:
2257:
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2221:(4): 429–32.
2220:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2187:
2184:(4): 376–84.
2183:
2179:
2173:
2169:
2165:
2161:
2157:
2153:
2149:
2145:
2141:
2137:
2132:
2128:
2124:
2119:
2114:
2110:
2106:
2102:
2097:
2096:
2083:
2079:
2074:
2069:
2064:
2059:
2055:
2051:
2047:
2043:
2039:
2031:
2023:
2019:
2015:
2011:
2008:(6): 706–14.
2007:
2003:
1995:
1987:
1983:
1978:
1973:
1968:
1963:
1959:
1955:
1951:
1943:
1935:
1931:
1927:
1923:
1918:
1913:
1910:(1–3): 23–9.
1909:
1905:
1901:
1893:
1891:
1882:
1878:
1874:
1870:
1867:(5): 720–30.
1866:
1862:
1854:
1846:
1842:
1837:
1832:
1828:
1824:
1821:(5): 925–36.
1820:
1816:
1812:
1804:
1796:
1792:
1788:
1784:
1781:(4): 885–92.
1780:
1776:
1768:
1766:
1757:
1753:
1748:
1743:
1738:
1733:
1729:
1725:
1722:(11): e7701.
1721:
1717:
1713:
1705:
1697:
1693:
1688:
1683:
1679:
1675:
1671:
1667:
1663:
1655:
1653:
1651:
1649:
1640:
1636:
1631:
1626:
1623:(2): 163–71.
1622:
1618:
1614:
1606:
1598:
1594:
1589:
1584:
1579:
1574:
1570:
1566:
1562:
1558:
1554:
1546:
1538:
1534:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1497:
1495:
1493:
1491:
1482:
1476:
1472:
1465:
1463:
1461:
1452:
1446:
1438:
1434:
1429:
1424:
1420:
1416:
1412:
1408:
1404:
1397:
1395:
1393:
1391:
1382:
1378:
1372:
1364:
1360:
1354:
1347:
1343:
1338:
1336:
1334:
1326:
1322:
1317:
1315:
1313:
1308:
1298:
1295:
1292:
1289:
1286:
1283:
1281:breast cancer
1280:
1277:
1274:
1273:
1272:
1269:
1266:
1260:
1257:
1256:
1255:
1247:
1243:
1240:
1231:
1228:
1226:
1225:
1219:
1217:
1213:
1209:
1204:
1202:
1198:
1194:
1184:
1182:
1178:
1174:
1170:
1167:
1163:
1153:
1151:
1147:
1142:
1140:
1135:
1131:
1126:
1122:
1112:
1110:
1106:
1102:
1098:
1094:
1090:
1079:
1077:
1072:
1068:
1064:
1060:
1055:
1053:
1050:
1046:
1042:
1030:
1025:
1021:
1017:
1014:
1010:
1003:
1001:
998:
994:
990:
986:
983:
979:
975:
968:
966:
962:
956:
952:
949:
943:
941:
937:
931:
927:
924:
920:
913:
911:
907:
901:
897:
894:
888:
886:
882:
876:
872:
869:
867:RefSeq (mRNA)
865:
858:
857:
852:
848:
845:
839:
838:
833:
829:
826:
824:
820:
813:
812:
807:
803:
800:
794:
793:
788:
784:
781:
779:
775:
768:
767:
762:
758:
755:
749:
748:
743:
739:
736:
734:
730:
727:
724:
722:
719:
715:
712:
708:
704:
697:
693:
688:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
631:cell division
629:
627:
624:
623:
621:
618:
617:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
572:
570:
567:
566:
560:
557:
555:
552:
551:
549:
546:
545:
542:
541:Gene ontology
538:
534:
522:
517:
513:
506:
499:
494:
491:
489:
485:
477:
472:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
362:
359:
355:
350:
347:
346:
343:
341:
337:
335:
334:
330:
329:
326:
324:
320:
316:
312:
308:
300:
295:
291:
287:
282:
272:
268:
261:
254:
248:
241:
233:
229:
225:
220:
216:
211:
207:
199:
194:
190:
186:
181:
171:
167:
160:
153:
147:
140:
136:
130:
126:
122:
117:
113:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
68:
64:
56:
51:
44:
39:
34:
30:
25:
20:
2694:
2688:
2653:
2649:
2623:(2): 142–7.
2620:
2616:
2575:
2571:
2544:
2540:
2501:
2498:FEBS Letters
2497:
2448:
2444:
2405:
2401:
2372:
2368:
2337:
2333:
2302:
2298:
2259:
2255:
2218:
2214:
2181:
2177:
2143:
2139:
2111:(2): 181–7.
2108:
2104:
2048:(8): e6495.
2045:
2041:
2030:
2005:
2001:
1994:
1957:
1953:
1942:
1907:
1904:FEBS Letters
1903:
1864:
1860:
1853:
1818:
1814:
1803:
1778:
1774:
1719:
1715:
1704:
1669:
1665:
1620:
1616:
1605:
1560:
1556:
1545:
1510:
1506:
1470:
1445:
1410:
1406:
1380:
1371:
1362:
1353:
1270:
1267:
1264:
1253:
1244:
1241:
1237:
1229:
1222:
1220:
1205:
1190:
1187:Interactions
1171:
1162:WD40 repeats
1159:
1143:
1123:, Bub3, and
1118:
1085:
1071:prometaphase
1056:
1048:
1040:
1039:
961:NP_001304279
958:
936:NP_001007794
933:
910:NM_001317350
903:
885:NM_001007793
878:
854:
835:
809:
790:
764:
745:
725:
720:
338:
331:
297:131,173,624
284:131,161,951
196:123,170,467
183:123,154,402
58:External IDs
1413:(1): 1–11.
1067:kinetochore
600:kinetochore
585:nucleoplasm
36:Identifiers
2710:Categories
1977:1822/61471
1954:Cell Cycle
1348:, May 2017
1327:, May 2017
1304:References
1234:Regulation
1218:and Mad3.
1166:beta sheet
651:cell cycle
580:chromosome
388:lymph node
342:(ortholog)
79:HomoloGene
1156:Structure
1152:complex.
965:NP_033904
940:NP_004716
906:NM_009774
881:NM_004725
711:Orthologs
87:GeneCards
2721:Proteins
2672:17289665
2637:15796961
2600:15635413
2563:15525512
2528:21762011
2520:15388328
2485:15302935
2432:12762840
2389:12242018
2356:12217960
2321:12011073
2286:11535616
2243:12645435
2235:11283619
2206:38578162
2198:11129339
2160:10828586
2127:10366450
2105:Genomics
2082:19652707
2042:PLOS ONE
2022:12473343
1986:18594200
1934:21762011
1926:15388328
1881:12419313
1845:11535616
1795:15544799
1756:19888327
1716:PLOS ONE
1696:11726501
1597:18591651
1537:10995385
1344:–
1323:–
1150:cohesion
1146:separase
1134:cyclin B
1082:Function
1063:anaphase
1013:Wikidata
690:Sources:
175:10q26.13
2608:4344740
2580:Bibcode
2453:Bibcode
2423:3225227
2277:2196190
2168:8371224
2073:2714964
2050:Bibcode
1836:2196190
1747:2765619
1724:Bibcode
1639:9734353
1588:2453698
1565:Bibcode
1437:9660858
1428:2133037
1346:Ensembl
1325:Ensembl
1130:Securin
1045:protein
823:UniProt
778:Ensembl
717:Species
696:QuickGO
641:meiosis
595:nucleus
575:cytosol
458:condyle
317:pattern
75:1343463
43:Aliases
2686:Human
2670:
2635:
2606:
2598:
2572:Nature
2561:
2526:
2518:
2483:
2476:514446
2473:
2430:
2420:
2387:
2354:
2319:
2284:
2274:
2241:
2233:
2204:
2196:
2166:
2158:
2125:
2080:
2070:
2020:
1984:
1932:
1924:
1879:
1843:
1833:
1793:
1754:
1744:
1694:
1687:125326
1684:
1637:
1595:
1585:
1535:
1528:316933
1525:
1477:
1435:
1425:
999:search
997:PubMed
856:Q9WVA3
837:O43684
733:Entrez
488:BioGPS
462:somite
392:embryo
67:603719
2604:S2CID
2524:S2CID
2239:S2CID
2202:S2CID
2164:S2CID
1930:S2CID
1212:Cdc20
1197:HDAC1
1193:BUB1B
1125:Cdc20
1121:BubR1
1043:is a
766:12237
726:Mouse
721:Human
692:Amigo
400:gonad
368:sperm
340:Mouse
333:Human
280:Start
215:Mouse
179:Start
112:Human
2695:BUB3
2689:BUB3
2668:PMID
2633:PMID
2596:PMID
2559:PMID
2516:PMID
2481:PMID
2428:PMID
2385:PMID
2369:Gene
2352:PMID
2317:PMID
2282:PMID
2231:PMID
2194:PMID
2156:PMID
2123:PMID
2078:PMID
2018:PMID
1982:PMID
1922:PMID
1877:PMID
1841:PMID
1791:PMID
1752:PMID
1692:PMID
1635:PMID
1593:PMID
1533:PMID
1475:ISBN
1433:PMID
1216:Mad2
1208:Mad1
1199:and
1181:Bub1
1177:WD40
1173:Rae1
1132:and
1109:MPS1
1107:and
1105:Mad3
1101:Mad2
1097:Mad1
1093:BUB2
1089:BUB1
1052:gene
1049:BUB3
747:9184
323:Bgee
271:Band
232:Chr.
170:Band
129:Chr.
91:BUB3
83:3470
63:OMIM
50:BUB3
22:BUB3
2658:doi
2654:282
2625:doi
2621:158
2588:doi
2576:433
2549:doi
2506:doi
2502:575
2471:PMC
2461:doi
2449:101
2418:PMC
2410:doi
2377:doi
2373:295
2342:doi
2307:doi
2303:277
2272:PMC
2264:doi
2260:154
2223:doi
2186:doi
2182:107
2148:doi
2113:doi
2068:PMC
2058:doi
2010:doi
1972:hdl
1962:doi
1912:doi
1908:575
1869:doi
1865:298
1831:PMC
1823:doi
1819:154
1783:doi
1779:344
1742:PMC
1732:doi
1682:PMC
1674:doi
1625:doi
1583:PMC
1573:doi
1561:105
1523:PMC
1515:doi
1423:PMC
1415:doi
1411:142
293:End
192:End
95:OMA
71:MGI
2712::
2666:.
2652:.
2648:.
2631:.
2619:.
2602:.
2594:.
2586:.
2574:.
2557:.
2545:16
2543:.
2539:.
2522:.
2514:.
2500:.
2496:.
2479:.
2469:.
2459:.
2447:.
2443:.
2426:.
2416:.
2406:38
2404:.
2400:.
2383:.
2371:.
2367:.
2350:.
2338:11
2336:.
2332:.
2315:.
2301:.
2297:.
2280:.
2270:.
2258:.
2254:.
2237:.
2229:.
2217:.
2200:.
2192:.
2180:.
2162:.
2154:.
2144:88
2142:.
2138:.
2121:.
2109:58
2107:.
2103:.
2076:.
2066:.
2056:.
2044:.
2040:.
2034:*
2016:.
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