305:
1477:
282:
204:
179:
2953:
311:
210:
28:
1267:
54:
1988:
Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON (July 1991). "BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner".
318:
217:
2032:
Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, et al. (July 1996). "Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells".
2552:
Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl".
2416:
Stanglmaier M, Warmuth M, Kleinlein I, Reis S, Hallek M (February 2003). "The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains".
2661:
Liedtke M, Pandey P, Kumar S, Kharbanda S, Kufe D (October 1998). "Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase".
111:, Bcr, 5133400C09Rik, AI561783, AI853148, mKIAA3017, ALL, BCR1, CML, D22S11, D22S662, PHL, RhoGEF and GTPase activating protein, BCR gene, BCR activator of RhoGEF and GTPase
2253:
Lionberger JM, Smithgall TE (February 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl".
1346:
1519:
between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second
990:
2082:
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, et al. (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL".
140:
971:
1722:
1704:
2952:
2622:"Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells"
51:
2816:
Wang L, Seale J, Woodcock BE, Clark RE (August 2002). "e19a2-positive chronic myeloid leukaemia with BCR exon e16-deleted transcripts".
1961:
Ling X, Ma G, Sun T, Liu J, Arlinghaus RB (January 2003). "Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr".
1817:
Zhao X, Ghaffari S, Lodish H, Malashkevich VN, Kim PS (February 2002). "Structure of the Bcr-Abl oncoprotein oligomerization domain".
1198:
2336:"The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase"
1205:
2871:
1452:
A reciprocal translocation between chromosomes 22 and 9 produces the
Philadelphia chromosome, which is often found in patients with
1803:
2995:
2932:
1687:
1366:
2130:"A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase"
2877:
1666:
1789:
1433:
304:
2461:"Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck"
2218:
Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL binding to BCR-ABL and BCR-ABL transformation".
281:
1691:
1670:
1500:
and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two
2287:"Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS"
1862:"Engineering and characterization of a<scp>pH</scp>-sensitive homodimeric antiparallel coiled coil"
1531:. Structure-based engineering starting from the antiparallel coiled coil domain of the BCR-ABL oncoprotein (BCR
1035:
1354:
1492:
of the BCR-ABL fusion protein. The BCR-ABL oncoprotein oligomerisation domain consists of a short N-terminal
203:
178:
1016:
1453:
120:
1544:
1513:
1428:
has been much studied, the function of the normal BCR gene product is still not clear. The protein has
1350:
317:
216:
2925:
2620:
Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, et al. (July 1995).
2373:
Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB (May 1997). "Bcr phosphorylated on tyrosine 177 binds Grb2".
310:
209:
107:
3000:
2864:
1742:"The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1"
1181:
1130:
128:
2706:"Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT"
2502:"The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain"
1569:
1429:
1410:
2860:
1160:
1156:
1109:
1105:
2638:
2621:
2755:"The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein"
2581:"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL"
1437:
192:
2918:
2766:
1476:
1333:
8:
2883:
1497:
148:
2770:
1460:
gene. The translocation produces a fusion protein that is encoded by sequence from both
2841:
2735:
2686:
2579:
Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, et al. (March 1995).
2441:
2398:
2107:
2057:
2045:
2014:
1929:
1889:
1842:
1766:
1741:
152:
2526:
2501:
2311:
2286:
2154:
2129:
1938:
1913:
1912:
Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, et al. (February 1994).
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
633:
628:
623:
618:
613:
608:
603:
598:
593:
588:
2899:
2890:
2833:
2794:
2789:
2754:
2727:
2678:
2643:
2602:
2561:
2531:
2517:
2482:
2433:
2390:
2355:
2316:
2262:
2235:
2200:
2159:
2145:
2099:
2049:
2006:
2002:
1970:
1943:
1893:
1881:
1834:
1771:
1413:. Two transcript variants encoding different isoforms have been found for this gene.
1341:
100:
44:
2845:
2739:
2690:
2177:
Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, et al. (January 1997).
2111:
2061:
1846:
1295:
2825:
2784:
2774:
2717:
2670:
2633:
2592:
2521:
2513:
2472:
2445:
2425:
2402:
2382:
2347:
2306:
2298:
2227:
2190:
2149:
2141:
2091:
2041:
2018:
1998:
1933:
1925:
1873:
1826:
1761:
1753:
1329:
397:
328:
272:
227:
132:
2981:
1307:
372:
156:
2128:
Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004).
1914:"Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway"
1740:
Dubash AD, Koetsier JL, Amargo EV, Najor NA, Harmon RM, Green KJ (August 2013).
1727:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1709:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2759:
Proceedings of the
National Academy of Sciences of the United States of America
2285:
Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (February 1995).
1505:
1425:
473:
2231:
2179:"Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation"
2989:
1885:
1524:
1509:
575:
2619:
2597:
2580:
2351:
2335:
2195:
2178:
1456:. The chromosome 22 breakpoint for this translocation is located within the
533:
411:
2837:
2829:
2731:
2674:
2535:
2486:
2477:
2460:
2437:
2429:
2386:
2359:
2266:
2239:
2163:
2095:
1974:
1838:
1775:
390:
169:
2798:
2779:
2704:
Park AR, Oh D, Lim SH, Choi J, Moon J, Yu DY, et al. (October 2012).
2682:
2647:
2606:
2565:
2394:
2320:
2204:
2103:
2053:
2010:
1947:
1757:
1245:
1240:
2302:
1516:
1501:
1080:
1061:
1861:
27:
2722:
1877:
1535:) resulted in a new pH-sensitive homodimeric antiparallel coiled coil.
1485:
1422:
289:
186:
136:
77:
73:
2127:
1489:
935:
356:
343:
255:
242:
144:
1480:
Schematic of the BCR-ABL formation through chromosomal translocation
2977:
2705:
1830:
1643:
1599:
1552:
1528:
1302:
1229:
2499:
2031:
2904:
2894:
1520:
1391:
1047:
1002:
920:
916:
876:
negative regulation of reactive oxygen species metabolic process
124:
2500:
Radziwill G, Erdmann RA, Margelisch U, Moelling K (July 2003).
2415:
1605:
1361:
1266:
1213:
957:
2910:
1816:
2961:: Structure of the Bcr-Abl Oncoprotein Oligomerization domain
1617:
1611:
1593:
1581:
1558:
1493:
2889:
Overview of all the structural information available in the
1484:
The BCR-ABL oncoprotein oligomerisation domain found at the
2973:
2660:
1623:
1575:
1564:
1441:
1398:
1323:
1290:
1271:
structure of the bcr-abl oncoprotein oligomerization domain
1987:
2458:
1739:
1629:
1587:
806:
platelet-derived growth factor receptor signaling pathway
1859:
380:
816:
regulation of small GTPase mediated signal transduction
2972:
This article incorporates text from the public domain
2815:
2551:
2284:
2217:
2176:
545:
2578:
2459:
Lionberger JM, Wilson MB, Smithgall TE (June 2000).
2081:
2252:
1860:Nagarkar RP, Fichman G, Schneider JP (2020-08-14).
508:
dentate gyrus of hippocampal formation granule cell
1911:
1683:
1681:
1679:
1662:
1660:
1658:
2903:(Human Breakpoint cluster region protein) at the
2752:
851:regulation of nitrogen compound metabolic process
327:
226:
2987:
2333:
1504:to assume a parallel orientation. The monomeric
2123:
2121:
1676:
1655:
791:negative regulation of neutrophil degranulation
2547:
2545:
2280:
2278:
2276:
2077:
2075:
2073:
2071:
1907:
1905:
1903:
1688:GRCm38: Ensembl release 89: ENSMUSG00000009681
756:negative regulation of blood vessel remodeling
2926:
2703:
1409:fusion protein, which is associated with the
866:intracellular protein transmembrane transport
811:regulation of Rho protein signal transduction
766:negative regulation of cellular extravasation
710:postsynaptic density, intracellular component
2753:Takeda N, Shibuya M, Maru Y (January 1999).
2697:
2493:
2452:
2409:
2327:
2246:
2211:
2118:
1960:
1954:
1804:"Entrez Gene: BCR breakpoint cluster region"
886:modulation of chemical synaptic transmission
821:negative regulation of inflammatory response
2746:
2654:
2613:
2572:
2542:
2366:
2273:
2170:
2068:
2025:
1981:
1900:
1810:
1667:GRCh38: Ensembl release 89: ENSG00000186716
1468:, the gene at the chromosome 9 breakpoint.
2933:
2919:
2639:10.1182/blood.V86.2.726.bloodjournal862726
1265:
1260:Bcr-Abl oncoprotein oligomerisation domain
599:guanyl-nucleotide exchange factor activity
2863:at the U.S. National Library of Medicine
2788:
2778:
2721:
2637:
2596:
2525:
2476:
2372:
2310:
2194:
2153:
1937:
1765:
891:small GTPase mediated signal transduction
741:neuromuscular process controlling balance
1790:"Entrez Gene: Breakpoint cluster region"
1475:
1447:
861:negative regulation of respiratory burst
609:protein serine/threonine kinase activity
871:cellular response to lipopolysaccharide
2988:
2334:Million RP, Van Etten RA (July 2000).
881:positive regulation of GTPase activity
2914:
1782:
786:negative regulation of cell migration
332:
293:
288:
231:
190:
185:
2585:The Journal of Biological Chemistry
2465:The Journal of Biological Chemistry
781:regulation of vascular permeability
731:positive regulation of phagocytosis
13:
2808:
2046:10.1046/j.1365-2141.1996.6102053.x
1930:10.1002/j.1460-2075.1994.tb06319.x
1543:The BCR protein has been shown to
1434:guanine nucleotide exchange factor
715:intracellular anatomical structure
14:
3012:
2854:
1394:that in humans is encoded by the
1388:renal carcinoma antigen NY-REN-26
1380:breakpoint cluster region protein
836:peptidyl-tyrosine phosphorylation
736:intracellular signal transduction
700:Schaffer collateral - CA1 synapse
2951:
2518:10.1128/MCB.23.13.4663-4672.2003
2146:10.1128/MCB.24.11.4685-4695.2004
624:protein tyrosine kinase activity
316:
309:
303:
280:
215:
208:
202:
177:
26:
2940:
1538:
1405:is one of the two genes in the
826:actin cytoskeleton organization
2506:Molecular and Cellular Biology
2291:Molecular and Cellular Biology
2134:Molecular and Cellular Biology
2034:British Journal of Haematology
1853:
1796:
1733:
1715:
1697:
846:homeostasis of number of cells
771:response to lipopolysaccharide
534:More reference expression data
438:olfactory zone of nasal mucosa
1:
1649:
1318:Available protein structures:
906:activation of GTPase activity
301:
200:
2996:Genes on human chromosome 22
2003:10.1016/0092-8674(91)90148-R
1512:through the formation of an
1488:of BCR is essential for the
1471:
1454:chronic myelogenous leukemia
896:keratinocyte differentiation
7:
1746:The Journal of Cell Biology
1637:
1416:
801:protein autophosphorylation
458:right lobe of thyroid gland
10:
3017:
2971:
2882:gene details page in the
695:protein-containing complex
2946:
2232:10.3109/10428199909093732
1819:Nature Structural Biology
1723:"Mouse PubMed Reference:"
1705:"Human PubMed Reference:"
1360:
1340:
1322:
1317:
1313:
1301:
1289:
1281:
1276:
1264:
1259:
1244:
1239:
1235:
1228:
1212:
1193:
1178:
1174:
1153:
1149:
1142:
1127:
1123:
1102:
1098:
1091:
1078:
1074:
1059:
1055:
1046:
1033:
1029:
1014:
1010:
1001:
988:
984:
969:
965:
956:
941:
934:
930:
914:
634:GTPase activator activity
574:
570:
558:
553:
544:
531:
480:
471:
418:
409:
379:
371:
367:
350:
337:
300:
279:
270:
266:
249:
236:
199:
176:
167:
163:
118:
115:
105:
98:
93:
70:
65:
48:
43:
38:
34:
25:
20:
2865:Medical Subject Headings
1199:Chr 22: 23.18 – 23.32 Mb
751:regulation of cell cycle
520:anterior amygdaloid area
2710:Journal of Cell Science
2598:10.1074/jbc.270.10.5039
2554:Experimental Hematology
2352:10.1182/blood.V96.2.664
2220:Leukemia & Lymphoma
2196:10.1182/blood.V89.1.297
1430:serine/threonine kinase
1411:Philadelphia chromosome
1206:Chr 10: 74.9 – 75.02 Mb
901:focal adhesion assembly
796:inner ear morphogenesis
761:protein phosphorylation
2830:10.1038/sj.leu.2402600
2675:10.1038/sj.onc.1202117
2478:10.1074/jbc.C000126200
2430:10.1038/sj.leu.2402778
2387:10.1038/sj.onc.1201053
2096:10.1038/sj.onc.1202024
1527:then associate into a
1496:(alpha-1), a flexible
1481:
856:definitive hemopoiesis
516:neural layer of retina
492:superior frontal gyrus
334:10 C1|10 38.49 cM
2780:10.1073/pnas.96.1.203
1758:10.1083/jcb.201304133
1479:
1448:Clinical significance
1438:Rho family of GTPases
705:glutamatergic synapse
690:extracellular exosome
660:postsynaptic membrane
504:primary visual cortex
295:Chromosome 10 (mouse)
193:Chromosome 22 (human)
2876:genome location and
2716:(Pt 19): 4518–4531.
2303:10.1128/MCB.15.2.835
841:renal system process
670:postsynaptic density
589:transferase activity
512:ventromedial nucleus
66:List of PDB id codes
39:Available structures
2884:UCSC Genome Browser
2771:1999PNAS...96..203T
2471:(24): 18581–18585.
831:signal transduction
2861:BCR+protein,+human
2723:10.1242/jcs.105502
1878:10.1002/pep2.24180
1482:
1432:activity and is a
1036:ENSMUSG00000009681
724:Biological process
643:Cellular component
594:nucleotide binding
582:Molecular function
484:olfactory tubercle
446:right frontal lobe
434:anterior pituitary
2969:
2968:
2669:(15): 1889–1892.
2591:(10): 5039–5047.
2512:(13): 4663–4672.
2381:(19): 2367–2372.
2140:(11): 4685–4695.
1534:
1508:associate into a
1421:Although the BCR-
1376:
1375:
1372:
1371:
1367:structure summary
1255:
1254:
1251:
1250:
1224:
1223:
1189:
1188:
1168:
1167:
1138:
1137:
1117:
1116:
1087:
1086:
1068:
1067:
1042:
1041:
1023:
1022:
997:
996:
978:
977:
926:
925:
776:brain development
566:
565:
562:
561:
540:
539:
527:
526:
488:nucleus accumbens
465:
464:
450:prefrontal cortex
422:nucleus accumbens
363:
362:
262:
261:
89:
88:
85:
84:
49:Ortholog search:
3008:
2955:
2935:
2928:
2921:
2912:
2911:
2849:
2824:(8): 1562–1563.
2803:
2802:
2792:
2782:
2750:
2744:
2743:
2725:
2701:
2695:
2694:
2658:
2652:
2651:
2641:
2617:
2611:
2610:
2600:
2576:
2570:
2569:
2549:
2540:
2539:
2529:
2497:
2491:
2490:
2480:
2456:
2450:
2449:
2413:
2407:
2406:
2370:
2364:
2363:
2331:
2325:
2324:
2314:
2282:
2271:
2270:
2261:(4): 1097–1103.
2250:
2244:
2243:
2226:(1–2): 119–126.
2215:
2209:
2208:
2198:
2174:
2168:
2167:
2157:
2125:
2116:
2115:
2079:
2066:
2065:
2029:
2023:
2022:
1985:
1979:
1978:
1958:
1952:
1951:
1941:
1918:The EMBO Journal
1909:
1898:
1897:
1857:
1851:
1850:
1814:
1808:
1807:
1800:
1794:
1793:
1786:
1780:
1779:
1769:
1737:
1731:
1730:
1719:
1713:
1712:
1701:
1695:
1685:
1674:
1664:
1532:
1386:) also known as
1315:
1314:
1269:
1257:
1256:
1237:
1236:
1208:
1201:
1184:
1172:
1171:
1163:
1147:
1146:
1143:RefSeq (protein)
1133:
1121:
1120:
1112:
1096:
1095:
1072:
1071:
1053:
1052:
1027:
1026:
1008:
1007:
982:
981:
963:
962:
932:
931:
572:
571:
551:
550:
536:
476:
474:Top expressed in
469:
468:
414:
412:Top expressed in
407:
406:
386:
385:
369:
368:
359:
346:
335:
320:
313:
307:
296:
284:
268:
267:
258:
245:
234:
219:
212:
206:
195:
181:
165:
164:
159:
110:
103:
80:
63:
62:
57:
36:
35:
30:
18:
17:
3016:
3015:
3011:
3010:
3009:
3007:
3006:
3005:
3001:Protein kinases
2986:
2985:
2984:
2970:
2965:
2962:
2956:
2942:
2939:
2857:
2852:
2811:
2809:Further reading
2806:
2751:
2747:
2702:
2698:
2659:
2655:
2618:
2614:
2577:
2573:
2550:
2543:
2498:
2494:
2457:
2453:
2414:
2410:
2371:
2367:
2332:
2328:
2283:
2274:
2255:Cancer Research
2251:
2247:
2216:
2212:
2175:
2171:
2126:
2119:
2080:
2069:
2030:
2026:
1986:
1982:
1963:Cancer Research
1959:
1955:
1910:
1901:
1866:Peptide Science
1858:
1854:
1815:
1811:
1802:
1801:
1797:
1788:
1787:
1783:
1738:
1734:
1721:
1720:
1716:
1703:
1702:
1698:
1686:
1677:
1665:
1656:
1652:
1640:
1635:
1541:
1474:
1450:
1419:
1272:
1246:View/Edit Mouse
1241:View/Edit Human
1204:
1197:
1194:Location (UCSC)
1180:
1159:
1155:
1129:
1108:
1104:
1017:ENSG00000186716
910:
746:phosphorylation
719:
675:plasma membrane
638:
614:protein binding
604:kinase activity
532:
523:
518:
514:
510:
506:
502:
498:
496:globus pallidus
494:
490:
486:
472:
461:
456:
452:
448:
444:
440:
436:
432:
428:
426:caudate nucleus
424:
410:
354:
341:
333:
323:
322:
321:
314:
294:
271:Gene location (
253:
240:
232:
222:
221:
220:
213:
191:
168:Gene location (
157:BCR - orthologs
119:
106:
99:
72:
50:
12:
11:
5:
3014:
3004:
3003:
2998:
2967:
2966:
2964:
2963:
2957:
2950:
2947:
2944:
2943:
2938:
2937:
2930:
2923:
2915:
2909:
2908:
2887:
2868:
2856:
2855:External links
2853:
2851:
2850:
2812:
2810:
2807:
2805:
2804:
2765:(1): 203–207.
2745:
2696:
2653:
2632:(2): 726–736.
2612:
2571:
2560:(2): 310–313.
2541:
2492:
2451:
2424:(2): 283–289.
2408:
2365:
2346:(2): 664–670.
2326:
2297:(2): 835–842.
2272:
2245:
2210:
2189:(1): 297–306.
2169:
2117:
2090:(8): 941–948.
2067:
2024:
1997:(1): 161–171.
1980:
1969:(2): 298–303.
1953:
1924:(4): 764–773.
1899:
1852:
1831:10.1038/nsb747
1825:(2): 117–120.
1809:
1795:
1781:
1752:(4): 653–666.
1732:
1714:
1696:
1675:
1653:
1651:
1648:
1647:
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1573:
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1562:
1556:
1549:
1540:
1537:
1473:
1470:
1449:
1446:
1426:fusion protein
1418:
1415:
1374:
1373:
1370:
1369:
1364:
1358:
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1344:
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986:
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672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
619:enzyme binding
616:
611:
606:
601:
596:
591:
585:
583:
579:
578:
568:
567:
564:
563:
560:
559:
556:
555:
548:
542:
541:
538:
537:
529:
528:
525:
524:
522:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
478:
477:
466:
463:
462:
460:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
416:
415:
403:
402:
394:
383:
377:
376:
373:RNA expression
365:
364:
361:
360:
352:
348:
347:
339:
336:
331:
325:
324:
315:
308:
302:
298:
297:
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277:
276:
264:
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251:
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214:
207:
201:
197:
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174:
173:
161:
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117:
113:
112:
104:
96:
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91:
90:
87:
86:
83:
82:
68:
67:
59:
58:
47:
41:
40:
32:
31:
23:
22:
9:
6:
4:
3:
2:
3013:
3002:
2999:
2997:
2994:
2993:
2991:
2983:
2979:
2975:
2960:
2954:
2949:
2948:
2945:
2936:
2931:
2929:
2924:
2922:
2917:
2916:
2913:
2906:
2902:
2901:
2896:
2892:
2888:
2885:
2881:
2880:
2875:
2874:
2869:
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2862:
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2858:
2847:
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2831:
2827:
2823:
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2814:
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2800:
2796:
2791:
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2749:
2741:
2737:
2733:
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2724:
2719:
2715:
2711:
2707:
2700:
2692:
2688:
2684:
2680:
2676:
2672:
2668:
2664:
2657:
2649:
2645:
2640:
2635:
2631:
2627:
2623:
2616:
2608:
2604:
2599:
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2590:
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2575:
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2548:
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2357:
2353:
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2337:
2330:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2292:
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2279:
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2268:
2264:
2260:
2256:
2249:
2241:
2237:
2233:
2229:
2225:
2221:
2214:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2173:
2165:
2161:
2156:
2151:
2147:
2143:
2139:
2135:
2131:
2124:
2122:
2113:
2109:
2105:
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2047:
2043:
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2035:
2028:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1992:
1984:
1976:
1972:
1968:
1964:
1957:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
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1895:
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1368:
1365:
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1352:
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1343:
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1335:
1331:
1328:
1325:
1321:
1316:
1312:
1309:
1306:
1304:
1300:
1297:
1294:
1292:
1288:
1285:Bcr-Abl_Oligo
1284:
1280:
1275:
1268:
1263:
1258:
1247:
1242:
1238:
1234:
1231:
1227:
1220:
1218:
1215:
1211:
1207:
1203:
1200:
1196:
1192:
1185:
1183:
1177:
1173:
1170:
1164:
1162:
1158:
1152:
1148:
1145:
1141:
1134:
1132:
1126:
1122:
1119:
1113:
1111:
1107:
1101:
1097:
1094:
1092:RefSeq (mRNA)
1090:
1083:
1082:
1077:
1073:
1070:
1064:
1063:
1058:
1054:
1051:
1049:
1045:
1038:
1037:
1032:
1028:
1025:
1019:
1018:
1013:
1009:
1006:
1004:
1000:
993:
992:
987:
983:
980:
974:
973:
968:
964:
961:
959:
955:
952:
949:
947:
944:
940:
937:
933:
929:
922:
918:
913:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
728:
726:
723:
722:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
685:cell junction
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
595:
592:
590:
587:
586:
584:
581:
580:
577:
576:Gene ontology
573:
569:
557:
552:
549:
547:
543:
535:
530:
519:
515:
511:
507:
503:
500:visual cortex
499:
495:
491:
487:
483:
482:
479:
475:
470:
467:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
420:
417:
413:
408:
405:
404:
401:
399:
395:
393:
392:
388:
387:
384:
382:
378:
374:
370:
366:
358:
353:
349:
345:
340:
330:
326:
319:
312:
306:
299:
291:
287:
283:
278:
274:
269:
265:
257:
252:
248:
244:
239:
229:
225:
218:
211:
205:
198:
194:
188:
184:
180:
175:
171:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
114:
109:
102:
97:
92:
81:
79:
75:
69:
64:
61:
60:
56:
53:
46:
42:
37:
33:
29:
24:
19:
16:
2958:
2898:
2878:
2872:
2821:
2817:
2762:
2758:
2748:
2713:
2709:
2699:
2666:
2662:
2656:
2629:
2625:
2615:
2588:
2584:
2574:
2557:
2553:
2509:
2505:
2495:
2468:
2464:
2454:
2421:
2417:
2411:
2378:
2374:
2368:
2343:
2339:
2329:
2294:
2290:
2258:
2254:
2248:
2223:
2219:
2213:
2186:
2182:
2172:
2137:
2133:
2087:
2083:
2037:
2033:
2027:
1994:
1990:
1983:
1966:
1962:
1956:
1921:
1917:
1869:
1865:
1855:
1822:
1818:
1812:
1798:
1784:
1749:
1745:
1735:
1726:
1717:
1708:
1699:
1542:
1539:Interactions
1514:antiparallel
1490:oncogenicity
1483:
1465:
1461:
1457:
1451:
1420:
1406:
1402:
1395:
1387:
1383:
1379:
1377:
1182:NP_001074881
1179:
1154:
1131:NM_001081412
1128:
1103:
1079:
1060:
1034:
1015:
989:
970:
950:
945:
396:
389:
116:External IDs
71:
15:
2941:PDB gallery
2040:(1): 5–16.
1517:coiled coil
1277:Identifiers
629:ATP binding
442:sural nerve
355:75,020,753
342:74,896,424
254:23,318,037
241:23,179,704
94:Identifiers
2990:Categories
1694:, May 2017
1673:, May 2017
1650:References
1486:N-terminus
1440:including
1330:structures
400:(ortholog)
137:HomoloGene
2982:IPR015123
1894:221920164
1886:2475-8817
1472:Structure
1308:IPR015123
1161:NP_067585
1157:NP_004318
1110:NM_021574
1106:NM_004327
936:Orthologs
650:cytoplasm
145:GeneCards
2978:InterPro
2846:24651759
2838:12145699
2818:Leukemia
2740:22422544
2732:22767509
2691:42228230
2663:Oncogene
2536:12808105
2487:10849448
2438:12592324
2418:Leukemia
2375:Oncogene
2360:10887132
2267:10706130
2240:10194128
2164:15143164
2112:20866214
2084:Oncogene
2062:30033345
1975:12543778
1847:17453012
1839:11780146
1776:23940119
1690:–
1669:–
1644:Abl gene
1638:See also
1620:(PTPrho)
1553:Abl gene
1545:interact
1529:tetramer
1436:for the
1417:Function
1347:RCSB PDB
1303:InterPro
1230:Wikidata
915:Sources:
665:membrane
454:amygdala
233:22q11.23
2905:PDBe-KB
2895:UniProt
2799:9874796
2767:Bibcode
2683:9788431
2648:7606002
2607:7534286
2566:8641358
2446:8695384
2403:9249479
2395:9178913
2321:7529874
2205:8978305
2104:9747873
2054:8757502
2019:9933891
2011:1712671
1948:8112292
1767:3747303
1692:Ensembl
1671:Ensembl
1521:monomer
1506:domains
1502:helices
1407:BCR-ABL
1392:protein
1296:PF09036
1048:UniProt
1003:Ensembl
942:Species
921:QuickGO
680:synapse
655:cytosol
430:putamen
375:pattern
101:Aliases
2900:P11274
2870:Human
2867:(MeSH)
2844:
2836:
2797:
2787:
2738:
2730:
2689:
2681:
2646:
2605:
2564:
2534:
2527:164848
2524:
2485:
2444:
2436:
2401:
2393:
2358:
2319:
2312:231961
2309:
2265:
2238:
2203:
2162:
2155:416425
2152:
2110:
2102:
2060:
2052:
2017:
2009:
1973:
1946:
1939:394874
1936:
1892:
1884:
1845:
1837:
1774:
1764:
1606:PIK3CG
1547:with:
1525:dimers
1523:. Two
1362:PDBsum
1336:
1326:
1282:Symbol
1216:search
1214:PubMed
1081:Q6PAJ1
1062:P11274
991:110279
958:Entrez
546:BioGPS
125:151410
2842:S2CID
2790:15117
2736:S2CID
2687:S2CID
2626:Blood
2442:S2CID
2399:S2CID
2340:Blood
2183:Blood
2108:S2CID
2058:S2CID
2015:S2CID
1890:S2CID
1872:(5).
1843:S2CID
1626:, and
1618:PTPRT
1612:PTPN6
1594:MLLT4
1582:GRB10
1559:CD117
1533:30-65
1510:dimer
1494:helix
1390:is a
951:Mouse
946:Human
917:Amigo
398:Mouse
391:Human
338:Start
273:Mouse
237:Start
170:Human
133:88141
2976:and
2974:Pfam
2959:1k1f
2893:for
2834:PMID
2795:PMID
2728:PMID
2679:PMID
2644:PMID
2603:PMID
2562:PMID
2532:PMID
2483:PMID
2434:PMID
2391:PMID
2356:PMID
2317:PMID
2263:PMID
2236:PMID
2201:PMID
2160:PMID
2100:PMID
2050:PMID
2007:PMID
1991:Cell
1971:PMID
1944:PMID
1882:ISSN
1835:PMID
1772:PMID
1624:SOS1
1576:Grb2
1565:CRKL
1498:loop
1464:and
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