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51:
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Albumin comprises three homologous domains that assemble to form a heart-shaped protein. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA,
1323:
Schoentgen F, Metz-Boutigue MH, Jollès J, Constans J, Jollès P (June 1986). "Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein".
1557:
Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (May 1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription".
1058:
legislation. Dip sticks, similar to common pregnancy tests, have been developed to detect the presence of bear albumin in traditional medicine products, indicating that bear bile had been used in their creation.
1272:
Haefliger DN, Moskaitis JE, Schoenberg DR, Wahli W (October 1989). "Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family".
413:
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The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.5 ångströms (250 pm). Albumin is a 65–70
2395:
1042:
which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulfide bonds.
897:
is the main protein of human blood plasma. It makes up around 50% of human plasma proteins. It binds water, cations (such as Ca, Na and K),
962:. The Vitamin-D binding proteins occupy families 1–3. The other albumins are mixed among each other in families 4–6. ECM1 is in family 6.
1927:
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337:
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Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K (June 1999). "Crystal structure of human serum albumin at 2.5 A resolution".
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A few other proteins are also sometimes called albumins. They are not in the same family as vertebrate albumins:
838:
A number of blood transport proteins are evolutionarily related in the albumin family, including serum albumin,
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2374:
1508:"Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin"
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196:
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2105:
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203:
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1361:"Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family"
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107:
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Mihara E, Hirai H, Yamamoto H, Tamura-Kawakami K, Matano M, Kikuchi A, et al. (February 2016).
905:, thyroxine (T4) and pharmaceuticals (including barbiturates). Its main function is to regulate the
185:
1980:
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provides an overview of all the structure information available in the PDB for Human Serum albumin.
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170:
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64:
36:
17:
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Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, et al. (July 1994).
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1990:
1976:
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163:
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27:
This article is about the class of proteins. For the substance sometimes called albumen, see
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1454:
Farrugia A (January 2010). "Albumin usage in clinical medicine: tradition or therapeutic?".
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1407:"Genome-Wide Identification and Comparative Analysis of Albumin Family in Vertebrates"
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Peppin L, McEwing R, Webster S, Rogers A, Nicholls D, Ogden R (September 2008).
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Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
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is a fetal plasma protein that binds various cations, fatty acids and bilirubin.
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In addition to their medical use, serum albumins are valued in biotechnology.
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binds to vitamin D and its metabolites, as well as to fatty acids.
31:. For the specific albumins found in vertebrate bloodstreams, see
2216:
2149:
1850:
1749:
1271:
958:
Albumins found in animals can be divided into six subfamilies by
349:
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Shewry PR, Pandya MJ (1999). "The 2S Albumin
Storage Proteins".
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Albumins in general are transport proteins that bind to various
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is a less canonical albumin. It regulates bone mineralization.
2364:
1358:
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1055:
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1025:". These are named for their egg-like coagulation property.
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1010:, although serum albumin also comprises a small part of it.
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1219:"Atomic structure and chemistry of human serum albumin"
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This article incorporates text from the public domain
811:. All of the proteins of the albumin family are water-
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1082:
1079:
860:
in a less strict sense can mean other proteins that
1091:
1073:
969:is usually used, although versions from humans and
177:. Unsourced material may be challenged and removed.
946:The four canonical human albumins are arranged on
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1006:, is a protein fraction of milk. It is mainly
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112:Improved diagram in structure section needed.
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890:and carry them around. Human types include:
831:. Substances containing albumins are called
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1167:
79:Learn how and when to remove these messages
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2396:disorders of globin and globulin proteins
1695:at the U.S. National Library of Medicine
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1125:(human serum albumin purification method)
255:Learn how and when to remove this message
237:Learn how and when to remove this message
135:Learn how and when to remove this message
1453:
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973:are also used to reduce animal cruelty.
866:
14:
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1672:"Pliny the Elder, The Natural History"
976:
1935:
1909:
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1054:contain wild bear bile, banned under
175:adding citations to reliable sources
146:
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44:
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1365:The Journal of Biological Chemistry
807:, the most common of which are the
24:
1411:Evolutionary Bioinformatics Online
950:region 4q13.3 in a tandem manner.
25:
2434:
1686:
1601:. Springer Netherlands. pp.
953:
819:. Albumins are commonly found in
60:This article has multiple issues.
1490:"Product Information data sheet"
1113:"(egg) white; dried egg white".
1069:
1045:
992:in egg white (albumen). It is a
151:
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1769:Post-translational modification
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850:. This family is only found in
162:needs additional citations for
68:or discuss these issues on the
2375:Extracellular matrix protein 1
1499:
1482:
1274:Journal of Molecular Evolution
1217:He XM, Carter DC (July 1992).
1062:
940:Extracellular matrix protein 1
932:. It seems to carry lipidated
864:under certain conditions. See
13:
1:
1378:10.1016/S0021-9258(17)32429-8
1146:
1052:traditional Chinese medicines
385:Available protein structures:
2106:Sex hormone-binding globulin
1748:
1676:Historia Naturalis 28, 6, 18
1611:10.1007/978-94-011-4431-5_24
1560:Journal of Molecular Biology
1456:Transfusion Medicine Reviews
1405:Li S, Cao Y, Geng F (2017).
1338:10.1016/0167-4838(86)90173-1
1029:
7:
1643:Endangered Species Research
1116:
881:
281:Structure of serum albumin.
110:. The specific problem is:
42:Family of globular proteins
10:
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1810:Protein structural domains
1708:Albumin binding prediction
1468:10.1016/j.tmrv.2009.09.005
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867:§ Other albumin types
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2370:Vitamin D-binding protein
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923:Vitamin D-binding protein
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1981:Alpha 1-antichymotrypsin
1697:Medical Subject Headings
1423:10.1177/1176934317716089
1191:10.1093/protein/12.6.439
928:Not much is known about
878:and plant "2S albumin".
37:Albumin (disambiguation)
2264:7S seed storage protein
2041:Retinol binding protein
1572:10.1006/jmbi.1996.0306
1067:Albumin is pronounced
823:and differ from other
35:. For other uses, see
2423:Seed storage proteins
2067:alpha-2-Macroglobulin
1873:Photoreceptor protein
936:and Vitamin E around.
827:in that they are not
2324:Bovine serum albumin
2140:Beta-2 microglobulin
1764:Protein biosynthesis
1417:: 1176934317716089.
1134:Bovine serum albumin
967:Bovine serum albumin
270:Serum albumin family
171:improve this article
117:improve this article
106:to meet Knowledge's
2319:Human serum albumin
2259:11S globulin family
2005:Heparin cofactor II
1995:Alpha 2-antiplasmin
1985:Alpha 1-antitrypsin
1703:The Albumin website
1525:10.7554/eLife.11621
1286:1989JMolE..29..344H
1235:1992Natur.358..209H
1179:Protein Engineering
1139:Human serum albumin
1050:Worldwide, certain
977:Other albumin types
895:Human serum albumin
2345:C-reactive protein
2237:Beta-lactoglobulin
1294:10.1007/BF02103621
1008:Beta-lactoglobulin
913:of albumin is 4.7.
2405:
2404:
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2354:Alpha-lactalbumin
2254:Alpha-lactalbumin
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2197:Fetal fibronectin
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1937:Globular proteins
1903:
1902:
1805:Protein structure
1779:Protein targeting
1620:978-94-011-4431-5
917:Alpha-fetoprotein
911:isoelectric point
840:alpha-fetoprotein
805:globular proteins
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434:structure summary
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108:quality standards
99:This article may
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16:(Redirected from
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1883:Phycobiliprotein
1841:Globular protein
1836:Membrane protein
1831:List of proteins
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1495:. Sigma Aldrich.
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1371:(27): 18149–54.
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2169:Gamma globulin
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954:Classification
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809:serum albumins
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2311:Serum albumin
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2280:
2277:
2275:
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2249:Thyroglobulin
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2240:
2239:
2238:
2235:
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2232:
2228:
2218:
2215:
2213:
2210:
2208:
2207:Microglobulin
2204:
2203:Macroglobulin
2201:
2198:
2194:
2191:
2190:
2188:
2184:
2178:
2175:
2174:
2172:
2170:
2166:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2127:
2125:
2119:
2112:
2109:
2107:
2104:
2103:
2101:
2097:
2092:
2089:
2087:
2083:
2072:
2068:
2064:
2061:
2057:
2056:
2054:
2048:
2042:
2039:
2036:
2035:Ceruloplasmin
2032:
2029:
2025:
2024:
2022:
2018:
2013:
2006:
2002:
1999:
1996:
1992:
1989:
1986:
1982:
1978:
1975:
1974:
1972:
1968:
1963:
1960:
1958:
1954:
1951:
1949:
1946:
1942:
1938:
1931:
1926:
1924:
1919:
1917:
1912:
1911:
1908:
1894:
1891:
1889:
1886:
1884:
1881:
1880:
1879:
1876:
1874:
1871:
1869:
1868:Chromoprotein
1866:
1864:
1861:
1857:
1854:
1852:
1849:
1847:
1844:
1843:
1842:
1839:
1837:
1834:
1832:
1829:
1828:
1826:
1822:
1816:
1813:
1811:
1808:
1806:
1803:
1802:
1800:
1796:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1762:
1761:
1759:
1755:
1751:
1744:
1739:
1737:
1732:
1730:
1725:
1724:
1721:
1714:
1711:
1709:
1706:
1704:
1701:
1698:
1694:
1691:
1690:
1677:
1673:
1666:
1657:
1652:
1649:(3): 263–70.
1648:
1644:
1637:
1630:
1622:
1616:
1612:
1608:
1604:
1599:
1598:
1597:Seed Proteins
1589:
1581:
1577:
1573:
1569:
1565:
1561:
1553:
1545:
1541:
1536:
1531:
1526:
1521:
1517:
1513:
1509:
1502:
1491:
1485:
1477:
1473:
1469:
1465:
1461:
1457:
1450:
1442:
1438:
1433:
1428:
1424:
1420:
1416:
1412:
1408:
1401:
1399:
1397:
1388:
1384:
1379:
1374:
1370:
1366:
1362:
1355:
1347:
1343:
1339:
1335:
1332:(2): 189–98.
1331:
1327:
1319:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1280:(4): 344–54.
1279:
1275:
1268:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1213:
1211:
1209:
1200:
1196:
1192:
1188:
1185:(6): 439–46.
1184:
1180:
1173:
1171:
1166:
1162:
1158:
1154:
1140:
1137:
1135:
1132:
1131:
1130:
1129:Serum albumin
1127:
1124:
1121:
1120:
1114:
1112:
1108:
1102:
1060:
1057:
1053:
1046:Forensic uses
1043:
1039:
1037:
1024:
1020:
1016:
1012:
1009:
1005:
1001:
998:
995:
991:
987:
984:
983:
982:
974:
972:
968:
963:
961:
951:
949:
941:
938:
935:
931:
927:
924:
921:
918:
915:
912:
908:
904:
900:
896:
893:
892:
891:
889:
879:
877:
873:
869:
868:
863:
859:
855:
853:
849:
845:
841:
836:
834:
830:
826:
822:
818:
814:
810:
806:
802:
798:
784:
778:
772:
766:
760:
754:
748:
742:
736:
730:
724:
718:
712:
706:
700:
694:
688:
682:
676:
670:
664:
658:
652:
646:
640:
634:
628:
622:
616:
610:
604:
598:
592:
586:
580:
574:
568:
562:
556:
550:
544:
538:
532:
526:
520:
514:
508:
502:
496:
490:
484:
478:
472:
466:
460:
454:
448:
444:
442:
438:
435:
432:
430:
426:
423:
419:
415:
412:
410:
406:
402:
398:
395:
392:
388:
383:
379:
376:
372:
368:
365:
363:
359:
356:
353:
351:
347:
344:
341:
339:
335:
332:
329:
327:
323:
320:
317:
314:
310:
307:
304:
302:
298:
295:Serum_albumin
294:
290:
285:
278:
273:
268:
259:
256:
241:
238:
230:
219:
216:
212:
209:
205:
202:
198:
195:
191:
188: –
187:
183:
182:Find sources:
176:
172:
166:
165:
160:This article
158:
154:
149:
148:
139:
136:
128:
125:November 2016
118:
113:
109:
105:
104:
97:
88:
87:
82:
80:
73:
72:
67:
66:
61:
56:
47:
46:
38:
34:
33:serum albumin
30:
19:
2392:
2273:
2001:Antithrombin
1855:
1675:
1665:
1646:
1642:
1629:
1596:
1588:
1566:(1): 113–9.
1563:
1559:
1552:
1515:
1511:
1501:
1484:
1462:(1): 53–63.
1459:
1455:
1449:
1414:
1410:
1368:
1364:
1354:
1329:
1325:
1318:
1277:
1273:
1267:
1226:
1222:
1182:
1178:
1123:Cohn process
1110:
1066:
1049:
1040:
1033:
1017:, including
1004:whey protein
980:
964:
957:
948:chromosome 4
945:
934:Wnt proteins
901:, hormones,
885:
865:
857:
856:
837:
832:
829:glycosylated
821:blood plasma
817:denaturation
796:
795:
251:
233:
224:
214:
207:
200:
193:
181:
169:Please help
164:verification
161:
131:
122:
115:Please help
111:
100:
76:
69:
63:
62:Please help
59:
2360:Parvalbumin
2350:Lactalbumin
2242:Lactoferrin
2193:Fibronectin
2150:Plasminogen
2130:Angiostatin
2111:Transferrin
2071:Haptoglobin
2060:Orosomucoid
2028:Transcortin
1888:Phytochrome
1878:Biliprotein
1670:Bostock J.
1063:Terminology
1023:2S albumins
1013:Some plant
1000:Lactalbumin
899:fatty acids
872:lactalbumin
852:vertebrates
833:albuminoids
287:Identifiers
119:if you can.
2412:Categories
2329:Prealbumin
2291:Conalbumin
1815:Proteasome
1798:Structures
1147:References
1021:, encode "
397:structures
227:March 2009
197:newspapers
65:improve it
2296:Ovalbumin
2283:Egg white
2155:Properdin
2135:Hemopexin
2065:alpha-2 (
2058:alpha-1 (
2033:alpha-2 (
2026:alpha-1 (
1948:globulins
1893:Lipocalin
1757:Processes
1161:IPR014760
1038:protein.
1030:Structure
986:Ovalbumin
960:phylogeny
903:bilirubin
876:ovalbumin
862:coagulate
780:,
774:,
768:,
762:,
756:,
750:,
744:,
738:,
732:,
726:,
720:,
714:,
708:,
702:,
696:,
690:,
684:,
678:,
672:,
666:,
660:,
654:,
648:,
642:,
636:,
630:,
624:,
618:,
612:,
606:,
600:,
594:,
588:,
582:,
576:,
570:,
564:,
558:,
552:,
546:,
540:,
534:,
528:,
522:,
516:,
510:,
504:,
498:,
492:,
486:,
480:,
474:,
468:,
462:,
456:,
450:,
331:IPR014760
186:"Albumin"
71:talk page
29:egg white
2393:see also
2274:Albumins
2145:Factor H
1846:Globulin
1784:Proteome
1750:Proteins
1693:Albumins
1544:26902720
1476:19962575
1441:28680266
1199:10388840
1157:InterPro
1117:See also
882:Function
858:Albumins
414:RCSB PDB
326:InterPro
101:require
18:Albumins
2217:Edestin
1991:alpha-2
1977:alpha-1
1967:serpins
1856:Albumin
1851:Edestin
1713:PDBe-KB
1580:8648639
1535:4775226
1432:5480655
1387:7517938
1346:2423133
1310:1456034
1302:2481749
1282:Bibcode
1259:4353741
1251:1630489
1231:Bibcode
1111:albumen
888:ligands
813:soluble
797:Albumin
786:
355:PS51438
350:PROSITE
343:SM00103
306:PF00273
211:scholar
103:cleanup
2301:Avidin
2195:(fFN:
2122:other:
2051:other:
1699:(MeSH)
1617:
1605:–586.
1578:
1542:
1532:
1474:
1439:
1429:
1385:
1344:
1308:
1300:
1257:
1249:
1223:Nature
1197:
994:serpin
930:afamin
848:afamin
801:family
429:PDBsum
403:
393:
375:SUPFAM
319:CL0282
292:Symbol
213:
206:
199:
192:
184:
2365:Ricin
2338:Other
2186:Other
1945:Serum
1824:Types
1639:(PDF)
1512:eLife
1493:(PDF)
1306:S2CID
1255:S2CID
1107:Latin
1056:CITES
1015:seeds
1002:, or
988:is a
799:is a
371:SCOPe
362:SCOP2
338:SMART
218:JSTOR
204:books
1615:ISBN
1576:PMID
1540:PMID
1472:PMID
1437:PMID
1383:PMID
1342:PMID
1298:PMID
1247:PMID
1195:PMID
1155:and
1153:Pfam
1019:hemp
870:for
846:and
783:3b9m
777:3b9l
771:2vuf
765:2vue
759:2vdb
753:2i30
747:2i2z
741:2bxq
735:2bxp
729:2bxo
723:2bxn
717:2bxm
711:2bxl
705:2bxk
699:2bxi
693:2bxh
687:2bxg
681:2bxf
675:2bxe
669:2bxd
663:2bxc
657:2bxb
651:2bxa
645:2bx8
639:1ysx
633:1uor
627:1tf0
621:1o9x
615:1n5u
609:1ma9
603:1lot
597:1kxp
591:1kw2
585:1j7e
579:1j78
573:1hk5
567:1hk4
561:1hk3
555:1hk2
549:1hk1
543:1ha2
537:1h9z
531:1gnj
525:1gni
519:1e7i
513:1e7h
507:1e7g
501:1e7f
495:1e7e
489:1e7c
483:1e7b
477:1e7a
471:1e78
465:1bm0
459:1bke
453:1bj5
447:1ao6
422:PDBj
418:PDBe
401:ECOD
391:Pfam
367:1ao6
315:clan
313:Pfam
301:Pfam
190:news
1651:doi
1607:doi
1603:563
1568:doi
1564:259
1530:PMC
1520:doi
1464:doi
1427:PMC
1419:doi
1373:doi
1369:269
1334:doi
1330:871
1290:doi
1239:doi
1227:358
1187:doi
1036:kDa
803:of
441:PDB
409:PDB
173:by
2414::
2069:,
1983:,
1674:.
1645:.
1641:.
1613:.
1574:.
1562:.
1538:.
1528:.
1518:.
1514:.
1510:.
1470:.
1460:24
1458:.
1435:.
1425:.
1415:13
1413:.
1409:.
1395:^
1381:.
1367:.
1363:.
1340:.
1328:.
1304:.
1296:.
1288:.
1278:29
1276:.
1253:.
1245:.
1237:.
1225:.
1221:.
1207:^
1193:.
1183:12
1181:.
1169:^
1159::
1109::
874:,
854:.
842:,
835:.
420:;
416:;
399:/
373:/
369:/
74:.
2356:)
2352:(
2205:/
2199:)
2098::
2073:)
2062:)
2037:)
2030:)
2019::
2007:)
2003:(
1997:)
1993:(
1987:)
1979:(
1969::
1929:e
1922:t
1915:v
1742:e
1735:t
1728:v
1678:.
1659:.
1653::
1647:9
1623:.
1609::
1582:.
1570::
1546:.
1522::
1516:5
1478:.
1466::
1443:.
1421::
1389:.
1375::
1348:.
1336::
1312:.
1292::
1284::
1261:.
1241::
1233::
1201:.
1189::
1101:/
1098:n
1095:ɪ
1092:m
1089:ʊ
1086:j
1083:b
1080:l
1077:æ
1074:ˈ
1071:/
996:.
258:)
252:(
240:)
234:(
229:)
225:(
215:·
208:·
201:·
194:·
167:.
138:)
132:(
127:)
123:(
81:)
77:(
39:.
20:)
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