253:
230:
152:
127:
504:
511:
518:
259:
158:
1014:. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. The function of Atrophin-1 has not yet been determined. There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional
2373:
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de
Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000).
1093:
In patients with DRPLA, truncated ATN1 has been observed forming intranuclear aggregates that cause cell death. The symptoms of this disorder can be credited to the significant reduction of brain and spinal tissue observed in those afflicted with DRPLA. There are both juvenile-onset and late
2265:
Hayashi Y, Kakita A, Yamada M, Koide R, Igarashi S, Takano H, Ikeuchi T, Wakabayashi K, Egawa S, Tsuji S, Takahashi H (December 1998). "Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain".
1050:
The ATN1 gene has a segment of DNA called the CAG trinucleotide repeat. It is made up of cytosine, adenine, and guanine. The number of CAG repeats in the ATN1 gene in a healthy person will range from six to thirty-five repeats. CAG repeats that exceed thirty-five can cause a
2045:
Yanagisawa H, Fujii K, Nagafuchi S, Nakahori Y, Nakagome Y, Akane A, Nakamura M, Sano A, Komure O, Kondo I, Jin DK, Sørensen SA, Potter NT, Young SR, Nakamura K, Nukina N, Nagao Y, Tadokoro K, Okuyama T, Miyashita T, Inoue T, Kanazawa I, Yamada M (March 1996).
2186:
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR (April 1998).
1870:
Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N (January 1994). "Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p".
1794:
Nagafuchi S, Yanagisawa H, Ohsaki E, Shirayama T, Tadokoro K, Inoue T, Yamada M (October 1994). "Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)".
1908:
Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T (January 1994). "Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)".
266:
165:
1832:
Burke JR, Wingfield MS, Lewis KE, Roses AD, Lee JE, Hulette C, Pericak-Vance MA, Vance JM (August 1994). "The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an
African-American family".
2305:"Single sperm analysis of the CAG repeats in the gene for dentatorubral-pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases"
1059:(NES). It has been shown that a mutation of the NES in ATN1 can change where ATN1 localizes, and can cause aggregation to occur in the nucleus. This can lead to an increase in cellular toxicity.
1055:
in ATN1. Studies have supported the idea that mutated
Atrophin-1 gathers in neurons and disrupts cell function. The sequence of the ATN1 gene contains a nuclear localizing signal (NLS) and a
2016:
Takano T, Yamanouchi Y, Nagafuchi S, Yamada M (February 1996). "Assignment of the dentatorubral and pallidoluysian atrophy (DRPLA) gene to 12p 13.31 by fluorescence in situ hybridization".
2340:"Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate"
1540:"Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate"
1757:
Yazawa I, Nukina N, Hashida H, Goto J, Yamada M, Kanazawa I (May 1995). "Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain".
736:
717:
88:
1283:"Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription"
2189:"Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract"
1724:"Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS"
1215:
1197:
951:
2485:
944:
1262:
1030:
The function of
Atrophin-1 has not been defined yet. It is widely hypothesized that Atrophin-1 functions as a transcriptional
2513:
1180:
1067:
2491:
2429:"Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine"
1635:"Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine"
2518:
1159:
2222:
Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (June 1998).
1584:
Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (June 1998).
252:
1184:
1163:
229:
2118:"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination"
1281:
Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA (September 2000).
781:
1063:
151:
126:
762:
68:
2469:
1103:
1018:. Atrophin-1 can be found in the nuclear and cytoplasmic compartments of neurons. It is expressed in
265:
164:
1948:"Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms"
258:
157:
55:
2478:
1983:"A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13"
902:
855:
76:
2224:"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins"
2081:
Margolis RL, Li SH, Young WS, Wagster MV, Stine OC, Kidwai AS, Ashworth RG, Ross CA (March 1996).
1586:"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins"
1070:" or "dentatorubropallidoluysian atrophy". Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare
2427:
Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000).
1633:
Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000).
927:
906:
876:
851:
2153:"Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis"
1094:
adult-onset variants of DRPLA, which show differing degrees of severity of specific symptoms.
1056:
140:
2048:"A unique origin and multistep process for the generation of expanded DRPLA triplet repeats"
1981:
Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (April 1996).
2387:
1038:
is a protein that indirectly suppresses the activity of specific genes by interacting with
17:
96:
8:
2497:
1039:
2391:
1356:
1331:
2303:
Takiyama Y, Sakoe K, Amaike M, Soutome M, Ogawa T, Nakano I, Nishizawa M (March 1999).
2291:
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1934:
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1820:
1782:
1740:
1723:
1705:
1680:
1615:
1488:
1471:
1369:
1307:
1282:
1090:. The disorder is related to the expansion of a trinucleotide repeat within this gene.
1079:
100:
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2004:
1969:
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1850:
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1710:
1681:"Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors"
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1607:
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1493:
1443:
1361:
1312:
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48:
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345:
276:
220:
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1514:
1083:
320:
104:
2376:"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"
1472:"Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy"
1220:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1202:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2380:
Proceedings of the
National Academy of Sciences of the United States of America
1019:
421:
1722:
Onodera O, Oyake M, Takano H, Ikeuchi T, Igarashi S, Tsuji S (November 1995).
1347:
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2169:
2152:
546:
503:
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481:
359:
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2428:
2419:
2400:
2365:
2240:
2223:
2151:
Miyashita T, Okamura-Oho Y, Mito Y, Nagafuchi S, Yamada M (November 1997).
2029:
1964:
1947:
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1602:
1585:
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2008:
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1749:
1611:
1556:
1539:
1298:
991:
986:
517:
1238:
826:
807:
1696:
1332:"Atrophins' emerging roles in development and neurodegenerative disease"
2372:
2134:
2117:
1999:
1982:
1846:
1808:
237:
134:
84:
1884:
1770:
2083:"DRPLA gene (atrophin-1) sequence and mRNA expression in human brain"
1946:
Li SH, McInnis MG, Margolis RL, Antonarakis SE, Ross CA (June 1993).
1922:
681:
304:
291:
203:
190:
92:
2426:
1632:
1087:
1052:
975:
1793:
1420:
Shen Y, Lee G, Choe Y, Zoltewicz JS, Peterson AS (February 2007).
2150:
1007:
793:
748:
666:
662:
2116:
Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (March 1997).
2044:
1869:
72:
2185:
2015:
1110:
959:
703:
526:
2337:
1537:
1239:"ATN1 atrophin 1 [Homo sapiens (human)] - Gene - NCBI"
1679:
Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC (March 2006).
1509:
1507:
1122:
1116:
1945:
1476:
International
Journal of Clinical and Experimental Pathology
1134:
1128:
1011:
2338:
Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (June 1999).
2302:
1538:
Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M (June 1999).
1504:
1907:
1721:
647:
negative regulation of transcription by RNA polymerase II
2264:
1831:
328:
2221:
2115:
1756:
1583:
2080:
1678:
1280:
493:
1980:
1419:
59:, B37, D12S755E, DRPLA, HRS, NOD, atrophin 1, CHEDDA
448:
dentate gyrus of hippocampal formation granule cell
1176:
1174:
1172:
1155:
1153:
1151:
275:
174:
2505:
1062:Mutations in ATN1 are associated with a form of
1169:
1148:
1579:
1577:
1575:
1465:
1463:
1461:
1459:
1457:
1181:GRCm38: Ensembl release 89: ENSMUSG00000004263
1515:"Dentatorubral-Pallidoluysian Atrophy, DRPLA"
1233:
1231:
1229:
1626:
1531:
1469:
1329:
1572:
1454:
1276:
1274:
1272:
1160:GRCh38: Ensembl release 89: ENSG00000111676
1226:
642:regulation of transcription, DNA-templated
2477:at the U.S. National Library of Medicine
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2409:
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2320:
2239:
2204:
2168:
2133:
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2063:
1998:
1963:
1739:
1704:
1650:
1601:
1555:
1487:
1437:
1355:
1306:
2087:Brain Research. Molecular Brain Research
1269:
1045:
14:
2506:
2470:GeneReviews/NCBI/NIH/UW entry on DRPLA
1422:"Functional architecture of atrophins"
1010:that in humans is encoded by the ATN1
1391:
1389:
1387:
1385:
1383:
1330:Shen Y, Peterson AS (February 2009).
1255:
280:
241:
236:
179:
138:
133:
2228:Molecular and Cellular Neurosciences
1590:Molecular and Cellular Neurosciences
1336:Cellular and Molecular Life Sciences
1068:dentatorubral-pallidoluysian atrophy
2193:The Journal of Biological Chemistry
2157:The Journal of Biological Chemistry
1426:The Journal of Biological Chemistry
24:
1728:American Journal of Human Genetics
1671:
1380:
637:central nervous system development
565:transcription corepressor activity
25:
2530:
2463:
1470:Suzuki Y, Yazawa I (April 2011).
516:
509:
502:
264:
257:
251:
228:
163:
156:
150:
125:
1413:
1097:
596:perinuclear region of cytoplasm
570:protein domain specific binding
1519:themedicalbiochemistrypage.org
1323:
1263:"Entrez Gene: ATN1 atrophin 1"
1208:
1190:
527:More reference expression data
482:More reference expression data
370:right hemisphere of cerebellum
13:
1:
1141:
1064:trinucleotide repeat disorder
249:
148:
2514:Genes on human chromosome 12
2100:10.1016/0169-328X(95)00241-J
652:transcription, DNA-templated
7:
1287:The Journal of Cell Biology
1025:
390:right lobe of thyroid gland
10:
2535:
2519:Transcription coregulators
2496:gene details page in the
1074:disorder characterized by
394:left lobe of thyroid gland
1348:10.1007/s00018-008-8403-9
1216:"Mouse PubMed Reference:"
1198:"Human PubMed Reference:"
1053:gain-of-function mutation
990:
985:
981:
974:
958:
952:Chr 6: 124.72 – 124.73 Mb
939:
924:
920:
899:
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888:
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2479:Medical Subject Headings
2433:Human Molecular Genetics
2344:Human Molecular Genetics
2309:Human Molecular Genetics
2170:10.1074/jbc.272.46.29238
2052:Human Molecular Genetics
1639:Human Molecular Genetics
1544:Human Molecular Genetics
632:neuron apoptotic process
2206:10.1074/jbc.273.15.9158
1685:Genes & Development
1401:Genetics Home Reference
1102:ATN1 has been shown to
27:Protein found in humans
2401:10.1073/pnas.97.7.3491
2241:10.1006/mcne.1998.0677
2030:10.1006/geno.1996.0100
1965:10.1006/geno.1993.1232
1603:10.1006/mcne.1998.0677
1439:10.1074/jbc.M610274200
945:Chr 12: 6.92 – 6.94 Mb
440:superior frontal gyrus
432:neural layer of retina
2280:10.1007/s004010050933
2268:Acta Neuropathologica
1299:10.1083/jcb.150.5.939
1057:nuclear export signal
1046:Clinical significance
436:primary visual cortex
141:Chromosome 12 (human)
2490:genome location and
2446:10.1093/hmg/9.9.1433
1652:10.1093/hmg/9.9.1433
1243:www.ncbi.nlm.nih.gov
1040:DNA-binding proteins
1034:. A transcriptional
282:6 F2|6 59.17 cM
243:Chromosome 6 (mouse)
2498:UCSC Genome Browser
2392:2000PNAS...97.3491D
2357:10.1093/hmg/8.6.947
2322:10.1093/hmg/8.3.453
2065:10.1093/hmg/5.3.373
1697:10.1101/gad.1393506
1557:10.1093/hmg/8.6.947
406:canal of the cervix
2135:10.1101/gr.7.3.268
2000:10.1101/gr.6.4.314
1847:10.1038/ng0894-521
1809:10.1038/ng1094-177
1080:myoclonic epilepsy
782:ENSMUSG00000004263
625:Biological process
584:Cellular component
553:Molecular function
382:right uterine tube
374:anterior pituitary
1885:10.1038/ng0194-14
1771:10.1038/ng0595-99
1076:cerebellar ataxia
1072:neurodegenerative
1001:
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488:
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452:cerebellar cortex
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16:(Redirected from
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2403:
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2182:
2172:
2163:(46): 29238–42.
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2137:
2112:
2102:
2077:
2067:
2041:
2012:
2002:
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1923:10.1038/ng0194-9
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889:RefSeq (protein)
879:
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499:
498:
484:
464:ventricular zone
444:genital tubercle
424:
422:Top expressed in
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362:
360:Top expressed in
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354:
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105:ATN1 - orthologs
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2504:
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2461:
2199:(15): 9158–67.
2122:Genome Research
1987:Genome Research
1911:Nature Genetics
1873:Nature Genetics
1835:Nature Genetics
1797:Nature Genetics
1759:Nature Genetics
1674:
1672:Further reading
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1084:choreoathetosis
1048:
1028:
992:View/Edit Mouse
987:View/Edit Human
950:
943:
940:Location (UCSC)
926:
905:
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763:ENSG00000111676
656:
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579:
560:protein binding
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456:muscle of thigh
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116:Gene location (
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2464:External links
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2439:(9): 1433–42.
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2262:
2219:
2183:
2148:
2113:
2078:
2042:
2013:
1978:
1943:
1905:
1867:
1829:
1791:
1754:
1734:(5): 1050–60.
1719:
1675:
1673:
1670:
1667:
1666:
1645:(9): 1433–42.
1625:
1571:
1530:
1503:
1453:
1432:(7): 5037–44.
1412:
1379:
1322:
1268:
1254:
1225:
1207:
1189:
1168:
1146:
1145:
1143:
1140:
1139:
1138:
1132:
1126:
1120:
1114:
1099:
1096:
1047:
1044:
1027:
1024:
1020:nervous tissue
999:
998:
995:
994:
989:
979:
978:
972:
971:
968:
967:
965:
963:
956:
955:
948:
941:
937:
936:
933:
932:
922:
921:
915:
912:
911:
897:
896:
890:
886:
885:
882:
881:
871:
870:
864:
861:
860:
846:
845:
839:
835:
834:
831:
830:
822:
821:
815:
812:
811:
803:
802:
796:
790:
789:
786:
785:
777:
776:
770:
767:
766:
758:
757:
751:
745:
744:
741:
740:
732:
731:
725:
722:
721:
713:
712:
706:
700:
699:
694:
689:
685:
684:
674:
673:
670:
669:
658:
657:
655:
654:
649:
644:
639:
634:
628:
626:
622:
621:
619:
618:
613:
608:
603:
598:
593:
591:nuclear matrix
587:
585:
581:
580:
578:
577:
572:
567:
562:
556:
554:
550:
549:
539:
538:
535:
534:
531:
530:
522:
521:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
468:tail of embryo
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
402:gastric mucosa
399:
398:body of uterus
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
9:
6:
4:
3:
2:
2531:
2520:
2517:
2515:
2512:
2511:
2509:
2499:
2495:
2494:
2489:
2488:
2483:
2480:
2476:
2473:
2471:
2468:
2467:
2456:
2452:
2447:
2442:
2438:
2434:
2430:
2425:
2421:
2417:
2412:
2407:
2402:
2397:
2393:
2389:
2386:(7): 3491–6.
2385:
2381:
2377:
2371:
2367:
2363:
2358:
2353:
2350:(6): 947–57.
2349:
2345:
2341:
2336:
2332:
2328:
2323:
2318:
2314:
2310:
2306:
2301:
2297:
2293:
2289:
2285:
2281:
2277:
2274:(6): 547–52.
2273:
2269:
2263:
2259:
2255:
2251:
2247:
2242:
2237:
2234:(3): 149–60.
2233:
2229:
2225:
2220:
2216:
2212:
2207:
2202:
2198:
2194:
2190:
2184:
2180:
2176:
2171:
2166:
2162:
2158:
2154:
2149:
2145:
2141:
2136:
2131:
2128:(3): 268–80.
2127:
2123:
2119:
2114:
2110:
2106:
2101:
2096:
2093:(2): 219–26.
2092:
2088:
2084:
2079:
2075:
2071:
2066:
2061:
2057:
2053:
2049:
2043:
2039:
2035:
2031:
2027:
2023:
2019:
2014:
2010:
2006:
2001:
1996:
1993:(4): 314–26.
1992:
1988:
1984:
1979:
1975:
1971:
1966:
1961:
1957:
1953:
1949:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1906:
1902:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1840:
1836:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1803:(2): 177–82.
1802:
1798:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1765:(1): 99–103.
1764:
1760:
1755:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1720:
1716:
1712:
1707:
1702:
1698:
1694:
1691:(5): 525–30.
1690:
1686:
1682:
1677:
1676:
1662:
1658:
1653:
1648:
1644:
1640:
1636:
1629:
1621:
1617:
1613:
1609:
1604:
1599:
1596:(3): 149–60.
1595:
1591:
1587:
1580:
1578:
1576:
1567:
1563:
1558:
1553:
1550:(6): 947–57.
1549:
1545:
1541:
1534:
1520:
1516:
1510:
1508:
1499:
1495:
1490:
1485:
1482:(4): 378–84.
1481:
1477:
1473:
1466:
1464:
1462:
1460:
1458:
1449:
1445:
1440:
1435:
1431:
1427:
1423:
1416:
1402:
1398:
1392:
1390:
1388:
1386:
1384:
1375:
1371:
1367:
1363:
1358:
1353:
1349:
1345:
1342:(3): 437–46.
1341:
1337:
1333:
1326:
1318:
1314:
1309:
1304:
1300:
1296:
1293:(5): 939–48.
1292:
1288:
1284:
1277:
1275:
1273:
1264:
1258:
1244:
1240:
1234:
1232:
1230:
1221:
1217:
1211:
1203:
1199:
1193:
1186:
1182:
1177:
1175:
1173:
1165:
1161:
1156:
1154:
1152:
1147:
1136:
1133:
1130:
1127:
1124:
1121:
1118:
1115:
1112:
1109:
1108:
1107:
1105:
1095:
1092:
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1060:
1058:
1054:
1043:
1041:
1037:
1033:
1023:
1021:
1017:
1013:
1009:
1005:
993:
988:
984:
980:
977:
973:
966:
964:
961:
957:
953:
949:
946:
942:
938:
931:
929:
923:
919:
916:
910:
908:
904:
898:
894:
891:
887:
880:
878:
872:
868:
865:
859:
857:
853:
847:
843:
840:
838:RefSeq (mRNA)
836:
829:
828:
823:
819:
816:
810:
809:
804:
800:
797:
795:
791:
784:
783:
778:
774:
771:
765:
764:
759:
755:
752:
750:
746:
739:
738:
733:
729:
726:
720:
719:
714:
710:
707:
705:
701:
698:
695:
693:
690:
686:
683:
679:
675:
668:
664:
659:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
617:
614:
612:
609:
607:
604:
602:
601:cell junction
599:
597:
594:
592:
589:
588:
586:
583:
582:
576:
573:
571:
568:
566:
563:
561:
558:
557:
555:
552:
551:
548:
547:Gene ontology
544:
540:
528:
523:
519:
512:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
2492:
2486:
2436:
2432:
2383:
2379:
2347:
2343:
2315:(3): 453–7.
2312:
2308:
2271:
2267:
2231:
2227:
2196:
2192:
2160:
2156:
2125:
2121:
2090:
2086:
2058:(3): 373–9.
2055:
2051:
2024:(1): 171–2.
2021:
2017:
1990:
1986:
1958:(3): 572–9.
1955:
1951:
1914:
1910:
1876:
1872:
1841:(4): 521–4.
1838:
1834:
1800:
1796:
1762:
1758:
1731:
1727:
1688:
1684:
1642:
1638:
1628:
1593:
1589:
1547:
1543:
1533:
1522:. Retrieved
1518:
1479:
1475:
1429:
1425:
1415:
1404:. Retrieved
1400:
1339:
1335:
1325:
1290:
1286:
1257:
1246:. Retrieved
1242:
1219:
1210:
1201:
1192:
1101:
1098:Interactions
1091:
1061:
1049:
1036:co-repressor
1032:co-repressor
1029:
1016:co-repressor
1003:
1002:
925:
903:NP_001007027
900:
874:
856:NM_001007026
849:
825:
806:
780:
761:
735:
716:
696:
691:
344:
337:
303:124,733,487
290:124,719,507
64:External IDs
1917:(1): 9–13.
1879:(1): 14–8.
1397:"ATN1 gene"
606:nucleoplasm
575:DNA binding
386:right ovary
42:Identifiers
2508:Categories
2475:atrophin-1
1524:2017-02-21
1406:2017-02-21
1248:2017-03-12
1187:, May 2017
1166:, May 2017
1142:References
1066:known as "
1004:Atrophin-1
378:left ovary
348:(ortholog)
202:6,942,321
189:6,924,463
85:HomoloGene
928:NP_031907
907:NP_001931
877:NM_007881
852:NM_001940
682:Orthologs
611:cytoplasm
93:GeneCards
2455:10814707
2420:10737800
2366:10332026
2296:12861680
2258:20003277
2018:Genomics
1952:Genomics
1939:27241147
1901:19708585
1863:40759301
1715:16481466
1661:10814707
1620:20003277
1566:10332026
1498:21577324
1448:17150957
1374:11380927
1366:18953689
1357:11131516
1317:10973986
1183:–
1162:–
1104:interact
1088:dementia
1026:Function
976:Wikidata
661:Sources:
181:12p13.31
2388:Bibcode
2331:9949204
2288:9845282
2250:9647693
2215:9535906
2179:9361003
2144:9074930
2109:8965642
2074:8852663
2038:8786114
2009:8723724
1974:8325628
1931:8136840
1893:8136826
1855:7951323
1825:2590882
1817:7842016
1787:5850726
1779:7647802
1750:7485154
1741:1801383
1706:1410805
1612:9647693
1489:3093063
1308:2175251
1185:Ensembl
1164:Ensembl
1008:protein
794:UniProt
749:Ensembl
688:Species
667:QuickGO
616:nucleus
323:pattern
49:Aliases
2484:Human
2481:(MeSH)
2453:
2418:
2408:
2364:
2329:
2294:
2286:
2256:
2248:
2213:
2177:
2142:
2107:
2072:
2036:
2007:
1972:
1937:
1929:
1899:
1891:
1861:
1853:
1823:
1815:
1785:
1777:
1748:
1738:
1713:
1703:
1659:
1618:
1610:
1564:
1496:
1486:
1446:
1372:
1364:
1354:
1315:
1305:
1131:, and
1111:BAIAP2
1106:with:
1086:, and
962:search
960:PubMed
827:O35126
808:P54259
704:Entrez
494:BioGPS
81:104725
73:607462
2411:16267
2292:S2CID
2254:S2CID
1935:S2CID
1897:S2CID
1859:S2CID
1821:S2CID
1783:S2CID
1616:S2CID
1370:S2CID
1123:MAGI2
1117:MAGI1
1006:is a
737:13498
697:Mouse
692:Human
663:Amigo
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
2493:ATN1
2487:ATN1
2451:PMID
2416:PMID
2362:PMID
2327:PMID
2284:PMID
2246:PMID
2211:PMID
2175:PMID
2140:PMID
2105:PMID
2070:PMID
2034:PMID
2005:PMID
1970:PMID
1927:PMID
1889:PMID
1851:PMID
1813:PMID
1775:PMID
1746:PMID
1711:PMID
1657:PMID
1608:PMID
1562:PMID
1494:PMID
1444:PMID
1362:PMID
1313:PMID
1135:WWP2
1129:RERE
1012:gene
718:1822
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
97:ATN1
89:1461
69:OMIM
56:ATN1
33:ATN1
18:ATN1
2441:doi
2406:PMC
2396:doi
2352:doi
2317:doi
2276:doi
2236:doi
2201:doi
2197:273
2165:doi
2161:272
2130:doi
2095:doi
2060:doi
2026:doi
1995:doi
1960:doi
1919:doi
1881:doi
1843:doi
1805:doi
1767:doi
1736:PMC
1701:PMC
1693:doi
1647:doi
1598:doi
1552:doi
1484:PMC
1434:doi
1430:282
1352:PMC
1344:doi
1303:PMC
1295:doi
1291:150
460:lip
299:End
198:End
101:OMA
77:MGI
2510::
2449:.
2435:.
2431:.
2414:.
2404:.
2394:.
2384:97
2382:.
2378:.
2360:.
2346:.
2342:.
2325:.
2311:.
2307:.
2290:.
2282:.
2272:96
2270:.
2252:.
2244:.
2232:11
2230:.
2226:.
2209:.
2195:.
2191:.
2173:.
2159:.
2155:.
2138:.
2124:.
2120:.
2103:.
2091:36
2089:.
2085:.
2068:.
2054:.
2050:.
2032:.
2022:32
2020:.
2003:.
1989:.
1985:.
1968:.
1956:16
1954:.
1950:.
1933:.
1925:.
1913:.
1895:.
1887:.
1875:.
1857:.
1849:.
1837:.
1819:.
1811:.
1799:.
1781:.
1773:.
1763:10
1761:.
1744:.
1732:57
1730:.
1726:.
1709:.
1699:.
1689:20
1687:.
1683:.
1655:.
1641:.
1637:.
1614:.
1606:.
1594:11
1592:.
1588:.
1574:^
1560:.
1546:.
1542:.
1517:.
1506:^
1492:.
1478:.
1474:.
1456:^
1442:.
1428:.
1424:.
1399:.
1382:^
1368:.
1360:.
1350:.
1340:66
1338:.
1334:.
1311:.
1301:.
1289:.
1285:.
1271:^
1241:.
1228:^
1218:.
1200:.
1171:^
1150:^
1082:,
1078:,
1042:.
1022:.
665:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
2500:.
2457:.
2443::
2437:9
2422:.
2398::
2390::
2368:.
2354::
2348:8
2333:.
2319::
2313:8
2298:.
2278::
2260:.
2238::
2217:.
2203::
2181:.
2167::
2146:.
2132::
2126:7
2111:.
2097::
2076:.
2062::
2056:5
2040:.
2028::
2011:.
1997::
1991:6
1976:.
1962::
1941:.
1921::
1915:6
1903:.
1883::
1877:6
1865:.
1845::
1839:7
1827:.
1807::
1801:8
1789:.
1769::
1752:.
1717:.
1695::
1663:.
1649::
1643:9
1622:.
1600::
1568:.
1554::
1548:8
1527:.
1500:.
1480:4
1450:.
1436::
1409:.
1376:.
1346::
1319:.
1297::
1265:.
1251:.
1222:.
1204:.
1137:.
1125:,
1119:,
1113:,
223:)
120:)
103::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
