1781:, Bayesian model-based dose-finding approaches evaluate the risk of toxicity across the entire range of doses being tested. By having a single continuous model (and unlike the conventional approach which effectively treats each dosing tier as a statistically separate study), information at one dosing level is carried across to another, factoring in any likely increase in risk of toxicity with higher dosing. Because of its greater efficiency, this approach accelerates decision making, because it can be used to predict the likely toxicity at the next dosing tier, and (subject to stipulated safety rules) may even allow intermediate dosing tiers to be skipped.
37:
3609:
3559:
1611:
1796:(i.e. estimating how likely a particular intervention is to have a better outcome than controls) for the chosen efficacy endpoint. For example, when evaluating the antiviral molnupiravir, the probability of a hazard ratio of >1.0 for swabs to become negative (by RNA detection) for molnupiravir was 75.4%, which fell just short of their pre-defined threshold of 8-0% for advancing a candidate to the next stage (Phase III) trial. In December 2022, results from the PANORAMIC trial (the largest
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3585:
1765:
AGILE differs from other trial platforms in several ways. The platform evaluates candidates at an early phase of drug development (including first-into-human use), utilising a seamless design to take the initial evaluation (focusing on drug safety and optimising the dose for clinical use) through to
1703:
which facilitates testing of novel and experimental therapies for SARS-CoV-2 infection; each candidate under investigation forms a separate candidate specific trial which sits under the umbrella of the master protocol. This approach allows flexibility to test and evaluate different treatments at the
1707:
AGILE was created out of the recognition that conventional drug development is not fit for purpose when responding to a pandemic, since it is too slow, lacking the ability to respond to an evolving pathogen, changes in host immunity and constantly changing epidemiology. While larger and later
1724:
data) in order to establish proof of efficacy, gaining sufficient confidence to be included into large efficacy trials. Selection of candidates into the AGILE platform has been through a combination of approaches: independent evaluation from an external group of experts, evaluation through the UK
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1915:"Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial"
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of molnupiravir) did not show any reduction in hospitalisations or death, although faster recovery times and modest improvements in
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1404:
1399:
1110:
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a preliminary evaluation of efficacy in patients infected with SARS-CoV-2. AGILE has received approval from the UK regulator (the
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were established in the UK to evaluate the efficacy of new treatments, AGILE evaluates new and experimental therapies at a much
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666:
2558:
1881:"First patient dosed in latest stage of AGILE COVID-19 drug trial - Articles - Clinical Directorate - University of Liverpool"
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2216:
1538:
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1725:
COVID-19 Therapeutics
Advisory Panel, and expertise within the trial team. The focus of AGILE shifted in 2022 to studying
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AGILE is a trial platform testing multiple treatments for COVID-19. Like other platform trials, AGILE utilises a
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988:
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for "AGILE: Seamless Phase I/IIa
Platform for the Rapid Evaluation of Candidates for COVID-19 Treatment" at
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584:
3426:
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2176:
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559:
2012:"AGILE trial reports on antiviral activity of COVID-19 drug molnupiravir - University of Liverpool News"
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2371:
2193:
1097:
1052:
1040:
993:
20:
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2954:
2855:
Health
Protection (Coronavirus, Restrictions) (Entry to Venues and Events) (England) Regulations 2021
2465:
2436:
1082:
858:
624:
569:
40:
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
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1913:
Khoo SH, FitzGerald R, Saunders G, Middleton C, Ahmad S, Edwards CJ, et al. (February 2023).
1687:, with additional funding for specific candidate evaluations from the pharmaceutical industry and
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2414:
1778:
1672:
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1370:
1072:
1057:
1025:
661:
63:
3519:
3405:
2860:
Coronavirus, Restrictions (All Tiers and Self-Isolation) (England) (Amendment) Regulations 2021
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1700:
1062:
1006:
705:
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1986:
963:
909:
1720:, including first evaluation in humans, selecting the most plausible candidates (based on
8:
3273:
2905:
2817:
Health
Protection (Coronavirus, Restrictions) (Self-Isolation) (England) Regulations 2020
2480:
2431:
2351:
3473:
3447:
2972:
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1963:"ÂŁ2.2m for Liverpool-led initiative to rapidly identify COVID-19 'game changing' drugs"
1939:
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1114:
649:
644:
1930:
1770:) to undertake first-into-human evaluations in individuals with SARS-CoV-2 infection.
3504:
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3412:
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2850:
Health
Protection (Coronavirus, Wearing of Face Coverings) (England) Regulations 2021
2807:
Coronavirus, Restrictions (Local
Authority Enforcement...) (England) Regulations 2020
2721:
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2404:
2366:
1944:
28:
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Coronavirus, International Travel and
Operator Liability (England) Regulations 2021
1934:
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2812:
Health
Protection (Coronavirus, Restrictions) (England) (No. 3) Regulations 2020
2777:
Health
Protection (Coronavirus, Restrictions) (England) (No. 4) Regulations 2020
1610:
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Health
Protection (Coronavirus, Business Closure) (England) Regulations 2020
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1679:(NIHR) Clinical Research Facilities. The AGILE platform is funded by the
2762:
Health Protection (Coronavirus, Restrictions) (England) Regulations 2020
3258:
3181:
1856:
1801:
1358:
953:
720:
55:
2644:
Parliamentary Under-Secretary of State for COVID-19 Vaccine Deployment
2419:
1092:
943:
2389:
1721:
1660:
49:
1688:
948:
2782:
Coronavirus, Restrictions (All Tiers) (England) Regulations 2020
3480:
1912:
1813:
2797:
Face Coverings in a Relevant Place (England) Regulations 2020
2792:
Face Coverings on Public Transport (England) Regulations 2020
3596:
2845:
Coronavirus, Restrictions (No. 2) (England) Regulations 2020
2802:
Coronavirus, Restrictions (Steps) (England) Regulations 2021
2787:
Coronavirus, International Travel (England) Regulations 2020
3116:
New and Emerging Respiratory Virus Threats Advisory Group
1691:. The Chief Investigator of the trial is Saye Hock Khoo.
1667:, working with the Southampton Clinical Trials Unit, the
3573:
1768:
Medicines and Healthcare products Regulatory Agency
1729:, and in particular antiviral combination therapy.
1663:. The trial platform is a collaboration led by the
3645:United Kingdom responses to the COVID-19 pandemic
1659:for early-phase evaluation of new treatments for
3621:
2752:Health Protection (Coronavirus) Regulations 2020
1745:, the monoclonal antibody Vir 7832, intravenous
3111:Joint Committee on Vaccination and Immunisation
2707:Stamp Duty Land Tax (Temporary Relief) Act 2020
1677:National Institute for Health and Care Research
2767:COVID-19 local lockdown regulations in England
2047:
1633:
3434:Hold Still: A Portrait of Our Nation in 2020
2712:Corporate Insolvency and Governance Act 2020
2634:Vaccines Manufacturing and Innovation Centre
2290:Saint Helena, Ascension and Tristan da Cunha
35:
2677:Public Health (Control of Disease) Act 1984
1908:
1906:
1904:
1902:
1900:
3640:Medical responses to the COVID-19 pandemic
2772:First COVID-19 tier regulations in England
2054:
2040:
1640:
1626:
3121:Scientific Advisory Group for Emergencies
1938:
1897:
3635:COVID-19 pandemic in the United Kingdom
3096:Imperial College COVID-19 Response Team
2627:European Commission–AstraZeneca dispute
2063:COVID-19 pandemic in the United Kingdom
1366:Neurological and psychological symptoms
3622:
3515:COVID-19 Bereaved Families for Justice
2009:
2035:
1669:Liverpool School of Tropical Medicine
2936:Cabinet Secretary for Covid Recovery
1833:
1831:
1829:
1737:Treatments under evaluation include
1671:, the MRC Biostatistics Unit at the
3630:Clinical trials related to COVID-19
2622:Oxford–AstraZeneca COVID-19 vaccine
1784:For Phase II efficacy evaluation a
13:
2950:Coughs and sneezes spread diseases
2425:Privileges Committee investigation
1792:of >1.0 when compared with the
14:
3656:
1991:The AGILE Clinical Trial Platform
1861:The AGILE Clinical Trial Platform
1826:
1807:
3607:
3595:
3583:
3557:
2891:Coronavirus Job Retention Scheme
1609:
2476:COVID-19 Genomics UK Consortium
1919:The Lancet. Infectious Diseases
1760:
2931:Can you look them in the eyes?
2717:Business and Planning Act 2020
2255:British Indian Ocean Territory
2003:
1979:
1955:
1873:
1849:
1775:Bayesian adaptive trial design
1708:phase trial platforms such as
1:
1931:10.1016/S1473-3099(22)00644-2
1819:
1732:
3545:National Covid Memorial Wall
2071:British Overseas Territories
1390:Alzheimer's disease patients
915:Misinformation and hesitancy
7:
2916:National Tutoring Programme
2692:Contingencies Fund Act 2021
2687:Contingencies Fund Act 2020
1694:
10:
3661:
2372:National Day of Reflection
3553:
3510:Coronavirus Tech Handbook
3497:
3378:
3343:
3287:
3246:
3220:
3129:
3086:
2990:
2965:
2955:Catch It, Bin It, Kill It
2881:
2872:
2835:
2744:
2672:
2665:
2656:
2612:
2567:
2504:
2471:Cancer Monitoring Project
2454:
2437:Scottish COVID-19 Inquiry
2380:
2342:
2307:
2230:
2202:
2162:
2155:
2077:
1749:, and the combination of
699:World Health Organization
3106:Joint Biosecurity Centre
2604:UK Rapid Test Consortium
2442:Virtual House of Commons
2400:Dominic Cummings scandal
2332:Exam grading controversy
2295:Turks and Caicos Islands
1788:for the likelihood of a
1681:Medical Research Council
869:Public health mitigation
553:By country and territory
2941:Pre-pandemic exercises
2911:Global Travel Taskforce
2697:Coronavirus mini-budget
2415:Northern Research Group
2016:University of Liverpool
2010:Morgan J (2022-11-02).
1779:frequentist evaluations
1673:University of Cambridge
1665:University of Liverpool
1371:Post-exertional malaise
711:Undercounting of deaths
3520:Death of Belly Mujinga
2896:Contract controversies
2260:British Virgin Islands
1837:Clinical trial number
1777:. Unlike conventional
1755:nirmatrelvir/ritonavir
1529:Science and technology
1405:Death rates by country
619:International response
41:
3535:London Blossom Garden
2727:Culture Recovery Fund
2614:Vaccination programme
2320:Cost-of-living crisis
2240:Akrotiri and Dhekelia
1554:Xenophobia and racism
1420:Emergency evacuations
39:
3295:Catherine Calderwood
2978:Overseas territories
2827:Coronavirus Act 2020
2588:Test, Trace, Protect
2395:COVID Recovery Group
2232:Overseas Territories
1661:SARS-CoV-2 infection
1289:Association football
910:Operation Warp Speed
3564:COVID-19 portal
3388:"Can You Hear Me" (
2906:Eat Out to Help Out
2702:Winter Economy Plan
2506:Temporary hospitals
2481:COVID Symptom Study
2466:Antiviral Taskforce
2352:Clap for Our Carers
1885:www.liverpool.ac.uk
1727:antiviral compounds
1487:Other health issues
1014:Variants of concern
3420:Grayson's Art Club
3006:July–December 2020
2594:Operation Moonshot
2582:NHS Test and Trace
2204:Crown Dependencies
2067:Crown Dependencies
1845:ClinicalTrials.gov
1786:Bayesian inference
979:Oxford–AstraZeneca
817:federal government
728:National responses
42:
3571:
3570:
3505:Captain Tom Moore
3441:Isolation Stories
3413:Failures of State
3374:
3373:
3264:Charlotte McArdle
3022:Northern Ireland
3001:January–June 2020
2986:
2985:
2868:
2867:
2740:
2739:
2722:Nightingale Court
2652:
2651:
2569:Testing programme
2450:
2449:
2405:Greensill scandal
2367:The 2.6 Challenge
2303:
2302:
1773:AGILE utilises a
1650:
1649:
1415:Domestic violence
1324:Gridiron football
1159:Financial markets
932:Vaccine passports
679:Social distancing
640:International aid
29:COVID-19 pandemic
3652:
3612:
3611:
3600:
3599:
3588:
3587:
3586:
3579:
3562:
3561:
3460:Pandemic Diaries
3274:Michelle O'Neill
3247:Northern Ireland
3233:Amanda Pritchard
3218:
3217:
3202:Jonathan Van-Tam
3197:Patrick Vallance
3101:Independent SAGE
2921:Pick for Britain
2879:
2878:
2670:
2669:
2663:
2662:
2577:NHS COVID-19 app
2502:
2501:
2410:Impact on Brexit
2340:
2339:
2285:Pitcairn Islands
2270:Falkland Islands
2184:Northern Ireland
2160:
2159:
2056:
2049:
2042:
2033:
2032:
2026:
2025:
2023:
2022:
2007:
2001:
2000:
1998:
1997:
1987:"The Agile Team"
1983:
1977:
1976:
1974:
1973:
1959:
1953:
1952:
1942:
1910:
1895:
1894:
1892:
1891:
1877:
1871:
1870:
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1867:
1853:
1847:
1835:
1814:Official website
1798:randomised trial
1642:
1635:
1628:
1614:
1613:
1122:Arts and culture
938:Current vaccines
864:Drug repurposing
859:Drug development
836:Medical response
16:
15:
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3659:
3655:
3654:
3653:
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3649:
3620:
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3574:
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3567:
3556:
3549:
3540:Lineage B.1.1.7
3493:
3406:Emergency State
3380:
3370:
3361:Vaughan Gething
3339:
3325:Nicola Sturgeon
3300:Joe FitzPatrick
3283:
3269:Michael McBride
3242:
3216:
3125:
3088:
3082:
2982:
2961:
2945:Exercise Cygnus
2864:
2837:
2831:
2736:
2648:
2608:
2599:Test to Release
2563:
2500:
2496:PANORAMIC trial
2486:COVID passports
2458:
2456:
2446:
2376:
2338:
2299:
2226:
2198:
2151:
2073:
2060:
2030:
2029:
2020:
2018:
2008:
2004:
1995:
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1985:
1984:
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1961:
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1911:
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1827:
1822:
1810:
1804:were reported.
1763:
1735:
1701:master protocol
1697:
1646:
1616:COVID-19 portal
1608:
1603:
1602:
1517:Catholic Church
1492:Popular culture
1354:
1344:
1343:
1184:Performing arts
1117:
1111:Economic impact
1103:
1102:
1098:Lineage B.1.617
1009:
999:
998:
984:Pfizer–BioNTech
842:Disease testing
837:
829:
828:
672:Fake treatments
620:
612:
611:
548:
538:
537:
82:
12:
11:
5:
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3568:
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3532:
3530:Notable deaths
3527:
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3501:
3499:
3495:
3494:
3492:
3491:
3484:
3477:
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3463:
3456:
3454:Lockdown Files
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3356:Mark Drakeford
3353:
3351:Frank Atherton
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3018:
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3003:
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2973:United Kingdom
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2491:RECOVERY Trial
2488:
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2468:
2462:
2460:
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2451:
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2432:Public inquiry
2429:
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2265:Cayman Islands
2262:
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2236:
2234:
2228:
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2200:
2199:
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2179:
2168:
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2164:United Kingdom
2157:
2153:
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2150:
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2148:
2147:
2142:
2137:
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2135:
2130:
2122:
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2107:
2106:
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2100:
2089:
2084:
2078:
2075:
2074:
2059:
2058:
2051:
2044:
2036:
2028:
2027:
2002:
1978:
1954:
1925:(2): 183–195.
1896:
1872:
1848:
1824:
1823:
1821:
1818:
1817:
1816:
1809:
1808:External links
1806:
1762:
1759:
1734:
1731:
1696:
1693:
1685:Wellcome Trust
1657:platform trial
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1482:Notable deaths
1479:
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1464:
1462:Media coverage
1459:
1457:Long-term care
1454:
1452:LGBT community
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1047:Other variants
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1033:
1028:
1023:
1017:
1016:
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989:Sinopharm BIBP
986:
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905:Authorizations
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745:European Union
742:
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713:
708:
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694:United Nations
691:
686:
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675:
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669:
667:by governments
662:Misinformation
659:
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3254:Arlene Foster
3252:
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3238:Simon Stevens
3236:
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3228:Stephen Powis
3226:
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3213:
3212:Nadhim Zahawi
3210:
3208:
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3192:Maggie Throup
3190:
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3167:Boris Johnson
3165:
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3157:Jenny Harries
3155:
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3142:Neil Ferguson
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2362:Thank You NHS
2360:
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2158:
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2143:
2141:
2138:
2134:
2133:July–December
2131:
2129:
2126:
2125:
2123:
2119:
2118:July–December
2116:
2114:
2111:
2110:
2108:
2104:
2103:July–December
2101:
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2096:
2095:
2093:
2092:
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2088:
2085:
2083:
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2079:
2076:
2072:
2068:
2064:
2057:
2052:
2050:
2045:
2043:
2038:
2037:
2034:
2017:
2013:
2006:
1992:
1988:
1982:
1968:
1964:
1958:
1950:
1946:
1941:
1936:
1932:
1928:
1924:
1920:
1916:
1909:
1907:
1905:
1903:
1901:
1886:
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1862:
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1771:
1769:
1758:
1756:
1752:
1748:
1744:
1740:
1730:
1728:
1723:
1719:
1718:earlier stage
1715:
1711:
1705:
1702:
1692:
1690:
1686:
1682:
1678:
1674:
1670:
1666:
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1493:
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1488:
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1478:
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1470:
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1467:Mental health
1465:
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1460:
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1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1305:
1304:Combat sports
1302:
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1297:
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1292:
1290:
1287:
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1238:
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1233:
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1229:
1226:
1224:
1221:
1215:
1212:
1210:
1209:sportscasting
1207:
1206:
1205:
1202:
1201:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1169:Food security
1167:
1165:
1164:Food industry
1162:
1160:
1157:
1155:
1152:
1150:
1147:
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1140:
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1128:
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992:
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987:
985:
982:
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977:
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967:
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957:
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870:
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865:
862:
860:
857:
853:
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848:
845:
844:
843:
840:
839:
833:
832:
825:
822:
818:
815:
814:
813:
810:
806:
803:
802:
801:
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3488:This England
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3446:
3439:
3432:
3425:
3418:
3411:
3404:
3397:
3389:
3335:Humza Yousaf
3330:John Swinney
3320:Devi Sridhar
3315:Gregor Smith
3310:Jason Leitch
3207:Chris Whitty
3177:Phil Prosser
3172:Wei Shen Lim
3152:Dido Harding
3147:Matt Hancock
3137:Kevin Fenton
2128:January–June
2113:January–June
2098:January–June
2019:. Retrieved
2015:
2005:
1994:. Retrieved
1990:
1981:
1970:. Retrieved
1966:
1957:
1922:
1918:
1888:. Retrieved
1884:
1875:
1864:. Retrieved
1860:
1851:
1838:
1790:hazard ratio
1783:
1772:
1764:
1761:Trial design
1751:molnupiravir
1743:nitazoxanide
1741:, high-dose
1739:molnupiravir
1736:
1706:
1698:
1652:
1651:
1534:Social media
1395:Black people
1339:Rugby league
1319:Gaelic games
927:Vaccine card
847:Breathalyzer
602:Cruise ships
3525:EveryDoctor
3474:Preventable
3448:Locked Down
3400:(series 35)
3279:Robin Swann
3187:Rishi Sunak
3162:Sajid Javid
2732:2021 budget
2682:2020 budget
2658:Legislation
2217:Isle of Man
1840:NCT04746183
1794:control arm
1747:favipiravir
1704:same time.
1583:New Zealand
1437:Environment
1260:New Zealand
1228:Video games
852:Development
785:Philippines
775:New Zealand
770:Netherlands
630:Evacuations
607:Naval ships
3624:Categories
3381:depictions
3259:Paul Givan
3182:June Raine
3130:Key people
2938:(Scotland)
2883:Government
2537:Washington
2532:Manchester
2517:Birmingham
2459:healthcare
2280:Montserrat
2087:Statistics
2021:2023-03-27
1996:2023-04-04
1972:2023-03-27
1890:2023-03-27
1866:2023-03-27
1857:"About us"
1820:References
1802:viral load
1733:Treatments
1683:, and the
1549:Telehealth
1410:Disability
1359:Long COVID
1334:Motorsport
1329:Ice hockey
1299:Basketball
1234:By country
1199:Television
1174:Journalism
954:Convidecia
900:Deployment
805:government
721:Zero-COVID
655:by country
635:Face masks
565:Antarctica
56:SARS-CoV-2
3467:Partygate
3042:Scotland
2991:Timelines
2874:Responses
2639:Taskforce
2584:(England)
2554:Gibraltar
2522:Harrogate
2420:Partygate
2327:Education
2275:Gibraltar
2156:Locations
2091:Timeline
1710:PANORAMIC
1568:Diplomacy
1502:Pregnancy
1472:Migration
1442:Hospitals
1425:Education
1314:Disc golf
1115:recession
1093:Cluster 5
994:Sputnik V
944:CoronaVac
650:Lockdowns
546:Locations
514:responses
502:responses
497:September
490:responses
478:responses
466:responses
454:responses
442:responses
430:responses
418:responses
406:responses
387:responses
375:responses
363:responses
351:responses
346:September
339:responses
327:responses
315:responses
303:responses
291:responses
279:responses
267:responses
255:responses
236:responses
224:responses
212:responses
200:responses
195:September
188:responses
176:responses
164:responses
152:responses
140:responses
128:responses
116:responses
104:responses
52:(disease)
3614:COVID-19
3590:Medicine
3498:See also
3398:Casualty
3288:Scotland
3087:Advisory
2997:England
2966:Military
2901:Lockdown
2838:or spent
2513:England
2390:Beergate
2382:Politics
2357:Protests
2245:Anguilla
2212:Guernsey
2189:Scotland
1949:36272432
1722:in-vitro
1714:RECOVERY
1695:Overview
1675:and the
1578:Malaysia
1561:Politics
1544:Suicides
1512:Religion
1497:Protests
1477:Military
1447:Language
1294:Baseball
1282:By sport
1255:Malaysia
1214:programs
1194:Shipping
1132:Cannabis
1127:Aviation
1007:Variants
888:Research
876:Vaccines
684:Software
526:December
521:November
413:February
382:December
370:November
262:February
231:December
219:November
111:February
80:Timeline
50:COVID-19
21:a series
19:Part of
3602:Viruses
3576:Portals
3390:Doctors
3221:England
2836:Expired
2745:Revoked
2666:Current
2590:(Wales)
2549:Cardiff
2544:Glasgow
2455:Science
2344:Society
2315:Economy
2250:Bermuda
2172:England
2082:History
1967:Unitaid
1940:9662684
1689:Unitaid
1573:Ireland
1539:Strikes
1507:Prisons
1385:Animals
1378:Society
1352:Impacts
1309:Cricket
1250:Ireland
1223:Tourism
1154:Fashion
1053:Epsilon
1041:Omicron
974:Novavax
969:Moderna
964:Medigen
959:Janssen
949:Covaxin
883:History
824:Vietnam
780:Nigeria
765:Ireland
750:Germany
585:Oceania
509:October
401:January
358:October
250:January
207:October
99:January
58:(virus)
3481:Staged
3089:bodies
3062:Wales
2559:Jersey
2527:London
2308:Impact
2222:Jersey
2177:London
1947:
1937:
1588:Russia
1430:Female
1265:Russia
1240:Canada
1189:Retail
1149:Disney
1137:Cinema
1083:Lambda
795:Sweden
790:Russia
735:Africa
689:Travel
645:Origin
575:Europe
560:Africa
485:August
334:August
183:August
69:Deaths
23:on the
3379:Media
3344:Wales
2194:Wales
2124:2022
2109:2021
2094:2020
1753:plus
1655:is a
1653:AGILE
1400:Crime
1245:India
1179:Music
1142:films
1078:Kappa
1068:Theta
1036:Delta
1031:Gamma
1021:Alpha
760:India
755:Ghana
740:China
437:April
425:March
286:April
274:March
135:April
123:March
64:Cases
3427:Help
3076:2022
3071:2021
3066:2020
3056:2022
3051:2021
3046:2020
3036:2022
3031:2021
3026:2020
3016:2022
3011:2021
2145:2024
2140:2023
2069:and
1945:PMID
1712:and
1522:Hajj
1113:and
1073:Iota
1058:Zeta
1026:Beta
893:VITT
570:Asia
533:2023
473:July
461:June
395:2022
322:July
310:June
244:2021
171:July
159:June
93:2020
87:2019
2457:and
1935:PMC
1927:doi
1063:Eta
449:May
298:May
147:May
3626::
2065:,
2014:.
1989:.
1965:.
1943:.
1933:.
1923:23
1921:.
1917:.
1899:^
1883:.
1859:.
1828:^
1757:.
1598:US
1593:UK
1275:US
1270:UK
1204:US
1088:Mu
920:US
812:US
800:UK
3578::
3392:)
2055:e
2048:t
2041:v
2024:.
1999:.
1975:.
1951:.
1929::
1893:.
1869:.
1641:e
1634:t
1627:v
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