24:
121:
unprecedented synthetic cannabinoids often feature alphanumeric code names intended to mimic the style of chemical nomenclature used by academic laboratories and pharmaceutical companies, and there is generally little, if any, information available regarding their pharmacology and toxicology at the time of first discovery.
664:
Blaazer, A. R.; Lange, J. H. M.; Van der Neut, M. A. W.; Mulder, A.; Den Boon, F. S.; Werkman, T. R.; Kruse, C. G.; Wadman, W. J. (2011). "Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties
120:
Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally designed by clandestine medicinal chemists. These
810:
Nahoko
Uchiyama; Yoshihiko Shimokawa; Maiko Kawamura; Ruri Kikura-Hanajiri; Takashi Hakamatsuka (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly
495:
Banister, S. D.; Moir, M.; Stuart, J.; Kevin, R. C.; Wood, K. E.; Longworth, M.; Wilkinson, S. M.; Beinat, C.; Buchanan, A. S.; Glass, M.; Connor, M.; McGregor, I. S.; Kassiou, M. (Sep 2015). "Pharmacology of Indole and
Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA,
773:"3-Naphthoylindazoles and 2-naphthoylbenzoimidazoles as novel chemical groups of synthetic cannabinoids: Chemical structure elucidation, analytical characteristics and identification of the first representatives in smoke mixtures"
213:— also known as 2NE1 and SDB-001, APICA is the carboxamide analogue of AB-001 and was similarly unknown in the scientific literature at the time of its discovery. Like AB-001, APICA is a CB
244:
732:"High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes"
41:
536:
Banister, SD; Stuart, J; Kevin, RC; Edington, A; Longworth, M; Wilkinson, SM; Beinat, C; Buchanan, AS; Hibbs, DE; Glass, M; Connor, M; McGregor, IS; Kassiou, M (2015).
176:
derivatives discovered as a designer cannabinoid. AB-001 was unknown in the scientific literature at the time of its discovery, and has since been characterized as a CB
629:
Uchiyama, N.; Kawamura, M.; Kikura-Hanajiri, R.; Goda, Y. (2012). "URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products".
580:
Banister, SD; Wilkinson, SM; Longworth, M; Stuart, J; Apetz, N; English, K; Brooker, L; Goebel, C; Hibbs, DE; Glass, M; Connor, M; McGregor, IS; Kassiou, M (2013).
88:
60:
848:"Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes"
67:
538:"Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135"
74:
56:
340:
700:
Wilkinson, S. M.; Banister, S. D.; Kassiou, M. (2015). "Bioisosteric
Fluorine in the Clandestine Design of Synthetic Cannabinoids".
81:
210:
107:
771:
Shevyrin, Vadim; Melkozerov, Vladimir; Nevero, Alexander; Eltsov, Oleg; Morzherin, Yuri; Shafran, Yuri (2014).
45:
846:
Xingxing Diao; Karl B. Scheidweiler; Ariane
Wohlfarth; Mingshe Zhu; Shaokun Pang; Marilyn A. Huestis (2016).
582:"The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse"
730:
Xingxing Diao; Ariane
Wohlfarth; Shaokun Pang; Karl B. Scheidweiler; Marilyn A. Huestis (October 2015).
383:— is a benzylic analogue of APICA, and was discovered during research related to AB-001 and APICA.
772:
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34:
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863:
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302:
496:
AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA".
881:
796:
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447:— the terminally trifluorinated (4,4,4-trifluorobutyl) analogue of
297:
193:
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597:
347:. NNE1 was first described in a paper by Abbott Laboratories in 2011.
129:
713:
23:
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389:— the terminally fluorinated (5-fluoro) analogue of APICA.
380:
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163:
147:
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162:— the terminally fluorinated (5-fluoropentyl) analogue of
128:— the terminally fluorinated (5-fluoropentyl) analogue of
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agonist possessing moderate cannabimimetic potency in rats.
437:— the terminally fluorinated (5-fluoro) analogue of
290:— the terminally fluorinated (5-fluoro) analogue of
699:
397:
jet propulsion system, and functions as an agonist at CB
494:
531:
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527:
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571:
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247:, is a 1,2-disubstituted benzimidazole analogue of
48:. Unsourced material may be challenged and removed.
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184:agonist with weak cannabimimetic activity in rats.
693:
892:
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622:
57:"List of miscellaneous designer cannabinoids"
803:
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108:Learn how and when to remove this message
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667:European Journal of Medicinal Chemistry
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46:adding citations to reliable sources
17:
13:
393:is believed to be named after the
231:is the indazole analogue of APICA.
14:
917:
421:— the indazole analogue of
411:— the indazole analogue of
343:, is the carboxamide analogue of
315:— the indazole analogue of
257:— the indazole analogue of
22:
811:detected in illegal products".
789:10.1016/j.forsciint.2014.06.022
702:Australian Journal of Chemistry
643:10.1016/j.forsciint.2012.08.047
33:needs additional citations for
777:Forensic Science International
631:Forensic Science International
276:-(4-fluorobenzyl) analogue of
245:JWH-018 benzimidazole analogue
227:— also known as AKB-48.
1:
482:
749:10.1373/clinchem.2015.243535
679:10.1016/j.ejmech.2011.08.021
554:10.1021/acschemneuro.5b00107
510:10.1021/acschemneuro.5b00112
172:— one of the earliest
7:
455:
10:
922:
665:and biological activity".
864:10.1007/s11419-016-0312-2
825:10.1007/s11419-014-0238-5
477:List of JWH cannabinoids
472:List of HU cannabinoids
467:List of CP cannabinoids
462:List of AM cannabinoids
331:— also known as
243:— also known as
42:improve this article
852:Forensic Toxicology
813:Forensic Toxicology
736:Clinical Chemistry
200:ADAMANTYL-THPINACA
673:(10): 5086–5098.
598:10.1021/cn400035r
586:ACS Chem Neurosci
542:ACS Chem Neurosci
498:ACS Chem Neurosci
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819:(2): 266–281.
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637:(1–3): 21–32.
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742:(1): 157–69.
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303:MDMB-FUBINACA
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59: –
58:
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53:Find sources:
47:
43:
37:
36:
31:This article
29:
25:
20:
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901:Cannabinoids
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429:WIN 55,212-2
273:
272:— the
206:AMB-FUBINACA
126:5F-AB-PINACA
119:
104:
95:
85:
78:
71:
64:
52:
40:Please help
35:verification
32:
15:
298:MDMB-CHMICA
194:AB-CHMINACA
895:Categories
483:References
405:receptors.
174:adamantane
160:5F-SDB-006
68:newspapers
906:ATC codes
783:: 72–80.
130:AB-PINACA
882:27547265
833:11873421
797:25036783
758:26430074
687:21885167
651:23063179
616:23551277
562:25921407
518:26134475
456:See also
419:THJ-2201
308:MMB-2201
288:FUBIMINA
265:FDU-NNE1
98:May 2016
873:4971051
607:3715837
431:—
423:AM-2201
413:JWH-018
409:THJ-018
395:STS-135
391:STS-135
387:STS-135
381:SDB-006
377:—
375:SDB-005
371:—
365:—
359:—
353:—
345:JWH-018
341:AM-6527
325:—
323:NM-2201
292:BIM-018
270:FUB-144
255:FAB-144
249:JWH-018
241:BIM-018
237:—
229:APINACA
225:APINACA
202:—
196:—
190:—
164:SDB-006
156:—
150:—
148:5F-NNE1
144:—
138:—
82:scholar
880:
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685:
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614:
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560:
516:
449:UR-144
445:XLR-12
439:UR-144
435:XLR-11
401:and CB
282:XLR-11
278:UR-144
259:XLR-11
217:and CB
188:AB-005
180:and CB
170:AB-001
154:5F-PCN
142:5F-ADB
136:5F-AMB
84:
77:
70:
63:
55:
829:S2CID
708:: 4.
351:PB-22
337:MN-24
313:MN-18
235:BB-22
211:APICA
89:JSTOR
75:books
878:PMID
793:PMID
754:PMID
683:PMID
647:PMID
612:PMID
558:PMID
514:PMID
369:PX-3
363:PX-2
357:PX-1
339:and
333:NNEI
329:NNE1
317:NNE1
280:and
61:news
868:PMC
860:doi
821:doi
785:doi
781:242
744:doi
710:doi
675:doi
639:doi
635:227
602:PMC
594:doi
550:doi
506:doi
44:by
897::
876:.
866:.
856:34
854:.
850:.
827:.
817:32
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862::
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274:N
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105:(
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96:(
86:·
79:·
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38:.
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