1886:
classically considered sex hormone responsive, including endometrial cancer, ovarian cancer, prostate cancer, and Leydig cell tumors. Although GPER signaling was originally thought to be tumor promoting in some breast cancer models, subsequent reports show that GPER signaling inhibits breast cancer. Consistent with this, recent studies showed that the presence of GPER protein in human breast cancer tissue correlates with longer survival. In summary, many independent groups have demonstrated that GPER activation may be a therapeutically useful mechanism for a wide range of cancer types.
244:
221:
143:
118:
502:
495:
250:
149:
2721:
amide form of nicotinic acid, named nicotinamide, acts as a vitamin although neither activates the GPR109A nor exhibits the pharmacological properties of nicotinic acid. In the present study, we demonstrate for the first time that nicotinic acid and nicotinamide bind to and activate the GPER-mediated signalling in breast cancer cells and cancer-associated fibroblasts (CAFs)
1508:. Since it takes time for genes to be transcribed into RNA and translated into protein, the effects of estrogens binding to these classical estrogen receptors is delayed. However, estrogens are also known to have effects that are too fast to be caused by regulation of gene transcription. In 2005, it was discovered that a member of the
1512:(GPCR) family, GPR30 also binds with high affinity to estradiol and is responsible in part for the rapid non-genomic actions of estradiol. Based on its ability to bind estradiol, GPR30 was renamed as G protein-coupled estrogen receptor (GPER). GPER is localized in the plasma membrane but is predominantly detected in the
2720:
Nicotinic acid, also known as niacin, is the water soluble vitamin B3 used for decades for the treatment of dyslipidemic diseases. Its action is mainly mediated by the G protein-coupled receptor (GPR) 109A; however, certain regulatory effects on lipid levels occur in a GPR109A-independent manner. The
1889:
Linnaeus
Therapeutics is currently running NCI clinical trial (NCT04130516) using GPER agonist, LNS8801, as monotherapy and in combination with the immune checkpoint inhibitor, pembrolizumab, for the treatment of multiple solid tumor malignancies. Activation of GPER with LNS8801 has demonstrated
1885:
Many groups have demonstrated that GPER signaling is tumor suppressive in cancers that are not traditionally hormone responsive, including melanoma, pancreatic, lung and colon cancer. Additionally, many groups have demonstrated that GPER activation is also tumor suppressive in cancers that are
4172:
The development of the GPER-selective agonist G-1 has facilitated studies that demonstrate GPER activation induces acute vasodilation and lowers blood pressure in rodents. We and others have shown that acute GPER-mediated vasodilator effects are at least partly endothelium- and
1852:
in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estradiol. The distribution of GPER is well established in the rodent, with high expression observed in the
2650:
Cheng SB, Dong J, Pang Y, LaRocca J, Hixon M, Thomas P, et al. (February 2014). "Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone".
3423:
Skrzypczak M, Schüler S, Lattrich C, Ignatov A, Ortmann O, Treeck O (November 2013). "G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines".
3021:
Sjöström M, Hartman L, Grabau D, Fornander T, Malmström P, Nordenskjöld B, et al. (May 2014). "Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer".
2089:
GPER is broadly expressed on the nervous system, and GPER activation promotes beneficial effects in several brain disorders. A study suggests that GPER levels were significantly lower in children with ADHD compared to controls.
257:
156:
3508:
Natale CA, Li J, Pitarresi JR, Norgard RJ, Dentchev T, Capell BC, et al. (9 July 2018). "Pharmacologic
Activation of the G Protein-Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma".
1881:
GPER expression has been studied in cancer using immunohistochemical and transcriptomic approaches, and has been detected in: colon, lung, melanoma, pancreatic, breast, ovarian, and testicular cancer.
3259:
Fábián M, Rencz F, Krenács T, Brodszky V, Hársing J, Németh K, et al. (September 2017). "Expression of G protein-coupled oestrogen receptor in melanoma and in pregnancy-associated melanoma".
4575:"17β-estradiol rapidly facilitates lordosis through G protein-coupled estrogen receptor 1 (GPER) via deactivation of medial preoptic nucleus μ-opioid receptors in estradiol primed female rats"
3173:
Zhu G, Huang Y, Wu C, Wei D, Shi Y (August 2016). "Activation of G-Protein-Coupled
Estrogen Receptor Inhibits the Migration of Human Nonsmall Cell Lung Cancer Cells via IKK-β/NF-κB Signals".
4673:"Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice"
7998:
7993:
3644:
Weißenborn C, Ignatov T, Poehlmann A, Wege AK, Costa SD, Zenclussen AC, et al. (April 2014). "GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells".
2817:
Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, et al. (April 2006). "Virtual and biomolecular screening converge on a selective agonist for GPR30".
3679:
Weißenborn C, Ignatov T, Ochel HJ, Costa SD, Zenclussen AC, Ignatova Z, et al. (May 2014). "GPER functions as a tumor suppressor in triple-negative breast cancer cells".
4318:
Estrada-Camarena E, López-Rubalcava C, Vega-Rivera N, Récamier-Carballo S, Fernández-Guasti A (September 2010). "Antidepressant effects of estrogens: a basic approximation".
9879:
2081:
volume, and persistent growth plate activity resulting in longer bones. The GPER-selective agonist G-1 shows therapeutic efficacy in mouse models of obesity and diabetes.
2774:
Catusse J, Wollner S, Leick M, Schröttner P, Schraufstätter I, Burger M (November 2010). "Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells".
1848:
and is a multi-pass membrane protein that localizes to the plasma membrane. The protein binds estradiol, resulting in intracellular calcium mobilization and synthesis of
2694:
Santolla MF, De
Francesco EM, Lappano R, Rosano C, Abonante S, Maggiolini M (July 2014). "Niacin activates the G protein estrogen receptor (GPER)-mediated signalling".
7757:
10111:
9451:
2029:. It is speculated that activation of GPER may be the mechanism by which estradiol mediates rapid effects on the oxytocin system, for instance, rapidly increasing
1601:
7930:
1890:
efficacy in humans in cutaneous melanoma, uveal melanoma, lung cancer, neuroendocrine cancer, colorectal cancer, and other PD-1 inhibitor refractory cancers.
5011:
4904:"Evaluation of estrogen and G protein-coupled estrogen receptor 1 (GPER) levels in drug-naïve patients with attention deficit hyperactivity disorder (ADHD)"
1575:
has been identified as an endogenous antagonist of the GPER. GPER-selective ligands (that do not bind the classical estrogen receptors) include the agonist
1155:
79:
4859:
Roque C, Mendes-Oliveira J, Duarte-Chendo C, Baltazar G (October 2019). "The role of G protein-coupled estrogen receptor 1 on neurological disorders".
3597:"The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo"
1136:
2216:
O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, et al. (January 1998). "Discovery of three novel G-protein-coupled receptor genes".
10026:
7223:
1639:
3296:"Author response: Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade"
3116:"GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation"
9792:
7983:
9843:
9835:
6161:
50:, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 1
9418:
6363:
6358:
6353:
6348:
2073:. Male GPER knockout mice are observed to have increased growth, body fat, insulin resistance and glucose intolerance, dyslipidemia, increased
10178:
10173:
9671:
9666:
9661:
9531:
2198:
4083:"Role of estrogen receptors and g protein-coupled estrogen receptor in regulation of hypothalamus-pituitary-testis axis and spermatogenesis"
2180:
10137:
10057:
9854:
9156:
8940:
1790:
1785:
1753:
1672:
1584:
1580:
1576:
8643:
9929:
9924:
9696:
9621:
7093:
2974:"Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues"
9904:
9899:
9746:
9741:
8093:
7923:
7483:
7478:
4979:
3843:"759 Phase 1b study of LNS8801 in combination with pembrolizumab in patients with secondary resistance to immune checkpoint inhibitors"
1849:
1382:
10239:
10072:
10067:
9751:
9586:
9541:
8890:
7514:
6859:
5004:
4624:"Tamoxifen and ICI 182,780 activate hypothalamic G protein-coupled estrogen receptor 1 to rapidly facilitate lordosis in female rats"
2260:"International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators"
1702:
1687:
1682:
9909:
9817:
9812:
9802:
9716:
9641:
8653:
7474:
6260:
6255:
1375:
9756:
7498:
7180:
7175:
7170:
6136:
4008:
Carreau S, Bois C, Zanatta L, Silva FR, Bouraima-Lelong H, Delalande C (October 2011). "Estrogen signaling in testicular cells".
2958:
9432:
7554:
6424:
6251:
4549:
Handbook of
Neurochemistry and Molecular Neurobiology: Behavioral Neurochemistry, Neuroendocrinology and Molecular Neurobiology
3716:"Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients"
3210:"Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer"
10234:
7916:
7165:
6111:
4557:
4527:
4234:
Han G, Li F, Yu X, White RE (May 2013). "GPER: a novel target for non-genomic estrogen action in the cardiovascular system".
3875:"GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast"
2163:
10272:
10267:
10229:
8725:
8203:
6339:
6151:
5621:
5359:
5354:
5349:
5344:
5339:
4997:
2470:
Filardo EJ, Thomas P (October 2005). "GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release".
9963:
7152:
5801:
2142:
1958:
1954:
3804:"1101P The effect of LNS8801 in combination with pembrolizumab in patients with treatment-refractory cutaneous melanoma"
8188:
8183:
7057:
6026:
8236:
7726:
7721:
7716:
7711:
7706:
7701:
7696:
7691:
5914:
5709:
5704:
5699:
5335:
2037:
and medial basal hypothalamus, actions that may be mediated by activation of GPER and/or ERβ. Estradiol, as well as
243:
8252:
7508:
7503:
6443:
6438:
5519:
5514:
4714:"GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice"
4187:"Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen"
8807:
8373:
9387:
7687:
7594:
6448:
5694:
5449:
4043:
Carreau S, Bouraima-Lelong H, Delalande C (June 2012). "Estrogen, a female hormone involved in spermatogenesis".
2167:
2146:
1985:, which also controls blood pressure, and is required for superoxide-mediated cardiovascular function and aging.
220:
8447:
8415:
2607:
Wendler A, Albrecht C, Wehling M (August 2012). "Nongenomic actions of aldosterone and progesterone revisited".
8638:
7543:
7538:
7072:
6313:
6308:
6156:
6005:
6000:
1950:
1555:. Although potentially involved in signaling by aldosterone, GPER does not show any detectable binding towards
1200:
4466:"Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol"
3765:"The effect of LNS8801 alone and in combination with pembrolizumab in patients with metastatic uveal melanoma"
7077:
4671:
Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, et al. (February 2009).
1181:
10224:
8538:
7534:
5874:
5869:
5105:
5100:
5095:
5085:
5080:
5075:
1982:
142:
117:
59:
9988:
8098:
8073:
10244:
8486:
7068:
5635:
5630:
5091:
5071:
3973:
Carreau S, Bouraima-Lelong H, Delalande C (November 2011). "Estrogens: new players in spermatogenesis".
1937:, ERα is the main receptor responsible for estrogen-mediated breast tissue growth. GPER is expressed in
256:
155:
8491:
6068:
6063:
5919:
5909:
5904:
5889:
5884:
5857:
5683:
5678:
5673:
5584:
5121:
5116:
5111:
5024:
4763:"GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state"
2735:"Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER"
2099:
1845:
1509:
249:
148:
9546:
9456:
8678:
6105:
6100:
6095:
5865:
5751:
5579:
5561:
5542:
5535:
5054:
4989:
46:
10107:
9869:
9782:
9407:
9100:
8633:
8628:
8528:
7660:
7529:
7489:
7135:
6059:
6021:
5880:
5669:
5593:
5547:
5037:
4970:
1497:
1333:
1329:
1278:
1274:
1270:
67:
4955:
9395:
9305:
8930:
8920:
8855:
8383:
8153:
6393:
6388:
6383:
6378:
6373:
6333:
6328:
6245:
6240:
6235:
6225:
6091:
5975:
5943:
5938:
5900:
5895:
5806:
5530:
3461:"Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells"
2022:
1926:
1727:
1525:
8193:
8168:
8108:
8103:
4812:"Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes"
4810:
Sharma G, Hu C, Staquicini DI, Brigman JL, Liu M, Mauvais-Jarvis F, et al. (January 2020).
1358:
1337:
1303:
1282:
9363:
8915:
8395:
8320:
8315:
8268:
6046:
6041:
5958:
5953:
5552:
5153:
5148:
4269:
Meyer MR, Fredette NC, Daniel C, Sharma G, Amann K, Arterburn JB, et al. (November 2016).
3763:
Shoushtari AN, Chaney MF, Cohen JV, Garyantes T, Lin JJ, Ishizuka JJ, et al. (June 2023).
3459:
Chimento A, Casaburi I, Bartucci M, Patrizii M, Dattilo R, Avena P, et al. (August 2013).
1930:
8123:
4547:
2911:"Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity"
9636:
9461:
9399:
8925:
8469:
8432:
8420:
8288:
7591:
6429:
6413:
6408:
6403:
6369:
6324:
6221:
6084:
6079:
6031:
5934:
5929:
5716:
5600:
5443:
5438:
5433:
5422:
5417:
5412:
5407:
5158:
5143:
5020:
4517:
3764:
3376:"Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer"
3065:
Smith HO, Arias-Pulido H, Kuo DY, Howard T, Qualls CR, Lee SJ, et al. (September 2009).
1513:
8198:
8173:
8148:
8133:
8068:
8008:
8003:
9056:
8713:
8452:
8358:
8300:
8078:
7641:
7299:
6611:
6434:
6419:
5996:
5949:
5626:
5605:
5390:
5385:
5380:
5375:
5370:
4317:
3802:
Rodon J, Chaney MF, Cohen J, Garyantes TK, Ishizuka J, Lin JJ, et al. (October 2023).
3294:
Natale CA, Li J, Zhang J, Dahal A, Dentchev T, Stanger BZ, et al. (17 November 2017).
3127:
3114:
Chevalier N, Vega A, Bouskine A, Siddeek B, Michiels JF, Chevallier D, et al. (2012).
2909:
Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, et al. (November 2011).
2426:
2034:
1501:
131:
87:
8138:
8013:
7988:
6285:
6280:
6275:
2515:"Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin"
2325:
2308:
8:
10117:
10032:
9096:
8880:
8737:
8703:
8513:
8213:
7464:
6399:
6290:
6074:
6037:
5502:
5131:
5063:
3323:
Ignatov T, Modl S, Thulig M, Weißenborn C, Treeck O, Ortmann O, et al. (July 2013).
2033:
expression. Estradiol has also been found to increase oxytocin levels and release in the
1732:
1645:
791:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
8128:
4966:
4417:"Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus"
4415:
Xu H, Qin S, Carrasco GA, Dai Y, Filardo EJ, Prossnitz ER, et al. (February 2009).
4134:"Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction"
4132:
Meyer MR, Amann K, Field AS, Hu C, Hathaway HJ, Kanagy NL, et al. (February 2012).
3841:
Rodon J, Chaney M, Cohen J, Garyantes T, Lin J, Lorusso P, et al. (November 2022).
3131:
2430:
10199:
9983:
9864:
9446:
9060:
8720:
8378:
8295:
8240:
8083:
8043:
8033:
7973:
7942:
7683:
7194:
7018:
6130:
6125:
6120:
6054:
5429:
5402:
5139:
4928:
4903:
4884:
4836:
4811:
4787:
4762:
4738:
4713:
4648:
4623:
4599:
4574:
4490:
4465:
4441:
4432:
4416:
4387:
4362:
4343:
4295:
4270:
4211:
4186:
4158:
4149:
4133:
4109:
4082:
3950:
3923:
3899:
3874:
3740:
3715:
3621:
3596:
3572:
3545:
3485:
3460:
3400:
3375:
3351:
3324:
3236:
3209:
3150:
3115:
3091:
3066:
3047:
2998:
2973:
2935:
2910:
2886:
2861:
2842:
2799:
2676:
2632:
2584:
2563:
2544:
2495:
2452:
2385:
2360:
2338:
2284:
2259:
2026:
1934:
1904:
1807:
1707:
1596:
1560:
1505:
91:
9787:
8063:
4712:
Ford J, Hajibeigi A, Long M, Hahner L, Gore C, Hsieh JT, et al. (February 2011).
4361:
Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, et al. (June 2009).
3986:
3780:
2860:
Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, et al. (June 2009).
2049:
through activation of GPER in the arcuate nucleus of the hypothalamus of female rats.
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
769:
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754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
594:
578:
573:
568:
558:
553:
548:
543:
9797:
9571:
9020:
8028:
8023:
7950:
7939:
7549:
7493:
7139:
6869:
6864:
6319:
6016:
5365:
4933:
4888:
4876:
4841:
4792:
4743:
4694:
4653:
4604:
4553:
4523:
4495:
4446:
4392:
4347:
4335:
4300:
4251:
4216:
4163:
4114:
4060:
4025:
3990:
3955:
3904:
3842:
3823:
3784:
3745:
3696:
3661:
3626:
3577:
3526:
3490:
3441:
3405:
3356:
3276:
3241:
3190:
3155:
3096:
3039:
3003:
2940:
2891:
2834:
2791:
2756:
2711:
2668:
2624:
2589:
2536:
2487:
2444:
2390:
2342:
2330:
2289:
2233:
2066:
2046:
2030:
1911:
1473:
39:
8178:
3854:
3714:
Martin SG, Lebot MN, Sukkarn B, Ball G, Green AR, Rakha EA, et al. (May 2018).
3051:
2803:
2680:
2636:
2548:
2499:
2456:
71:
10047:
9516:
8481:
8228:
8113:
8053:
8048:
8038:
8018:
7978:
6344:
6266:
6116:
4923:
4915:
4868:
4831:
4823:
4782:
4774:
4733:
4725:
4684:
4643:
4635:
4594:
4586:
4485:
4477:
4436:
4428:
4382:
4374:
4327:
4290:
4282:
4243:
4206:
4198:
4153:
4145:
4104:
4094:
4052:
4017:
3982:
3945:
3935:
3894:
3886:
3850:
3815:
3803:
3776:
3735:
3727:
3688:
3653:
3616:
3608:
3567:
3557:
3518:
3480:
3472:
3437:
3433:
3395:
3387:
3346:
3336:
3303:
3268:
3231:
3221:
3182:
3145:
3135:
3086:
3078:
3031:
2993:
2985:
2930:
2922:
2881:
2873:
2846:
2826:
2783:
2751:
2746:
2734:
2703:
2660:
2620:
2616:
2579:
2571:
2526:
2479:
2434:
2380:
2372:
2320:
2279:
2271:
2225:
1933:
knockout mice. This indicates that although GPER and ERβ play a modulatory role in
1870:
1661:
336:
267:
211:
166:
8158:
3819:
2972:
Hazell GG, Yao ST, Roper JA, Prossnitz ER, O'Carroll AM, Lolait SJ (August 2009).
2707:
1978:
1824:
9606:
9339:
9213:
8845:
8792:
8747:
8548:
7737:
7524:
7333:
6622:
6304:
6271:
6011:
5308:
5293:
5288:
5283:
5273:
5268:
5263:
5258:
5253:
4827:
4331:
3140:
2078:
2010:
1946:
1862:
1858:
311:
95:
9317:
9313:
9291:
4872:
4639:
4590:
3082:
2926:
2203:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2185:
National Center for
Biotechnology Information, U.S. National Library of Medicine
10077:
9839:
9711:
9140:
8860:
8832:
8824:
8663:
8568:
8558:
8503:
8498:
8400:
8218:
8118:
7908:
7610:
6470:
6298:
5525:
5318:
5313:
5303:
5279:
5249:
5244:
4247:
4202:
3595:
Wei W, Chen ZJ, Zhang KS, Yang XL, Wu YM, Chen XH, et al. (October 2014).
3374:
Lam HM, Ouyang B, Chen J, Ying J, Wang J, Wu CL, et al. (6 October 2014).
2415:"A transmembrane intracellular estrogen receptor mediates rapid cell signaling"
2070:
2058:
1994:
1915:
1866:
1692:
412:
4761:
Sharma G, Hu C, Brigman JL, Zhu G, Hathaway HJ, Prossnitz ER (November 2013).
4481:
4286:
4056:
4021:
3890:
3731:
3692:
3657:
3226:
3035:
2664:
2575:
2483:
1464:
and is responsible for some of the rapid effects that estradiol has on cells.
501:
494:
10261:
9691:
9526:
9501:
9281:
9199:
9032:
9010:
8865:
8742:
8474:
8325:
8283:
7665:
7314:
7309:
7304:
6230:
6166:
5234:
4983:
4919:
4099:
3940:
3827:
3788:
3562:
2062:
1919:
1477:
530:
3308:
3295:
2439:
2414:
563:
472:
350:
9859:
9831:
9807:
9676:
9601:
9511:
9506:
9496:
9299:
9265:
9255:
9251:
9186:
9180:
9112:
8608:
8598:
8573:
8437:
8390:
8244:
8232:
7587:
5985:
5979:
5589:
5574:
5397:
5164:
4937:
4880:
4845:
4796:
4747:
4698:
4657:
4622:
Long N, Long B, Mana A, Le D, Nguyen L, Chokr S, et al. (March 2017).
4608:
4499:
4450:
4396:
4339:
4304:
4255:
4220:
4167:
4118:
4064:
4029:
3994:
3959:
3908:
3749:
3700:
3665:
3630:
3612:
3581:
3530:
3494:
3476:
3445:
3409:
3360:
3341:
3280:
3245:
3194:
3159:
3100:
3043:
3007:
2944:
2895:
2838:
2795:
2760:
2715:
2672:
2628:
2593:
2540:
2491:
2448:
2413:
Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER (March 2005).
2394:
2334:
2293:
2229:
2018:
1974:
1854:
1712:
1564:
1548:
1544:
966:
negative regulation of vascular associated smooth muscle cell proliferation
329:
108:
3186:
2275:
2237:
1422:
1417:
886:
positive regulation of cardiac vascular smooth muscle cell differentiation
10204:
10132:
10097:
10092:
10052:
10022:
10008:
9998:
9993:
9822:
9766:
9761:
9656:
9651:
9631:
9581:
9556:
9551:
9476:
9466:
9383:
9379:
9375:
9367:
9357:
9353:
9321:
9309:
9295:
9287:
9227:
9160:
9104:
9076:
8910:
8885:
8757:
8658:
8533:
8457:
8427:
8278:
8258:
8208:
8162:
8058:
4858:
4778:
4689:
4672:
4378:
3208:
Liu Q, Chen Z, Jiang G, Zhou Y, Yang X, Huang H, et al. (May 2017).
2877:
2376:
2042:
1970:
1812:
1748:
1717:
1666:
1635:
1621:
1611:
1606:
1556:
1245:
1226:
1066:
adenylate cyclase-activating G protein-coupled receptor signaling pathway
956:
positive regulation of epidermal growth factor receptor signaling pathway
4519:
Oxytocin, Vasopressin and
Related Peptides in the Regulation of Behavior
3391:
2989:
2830:
2077:
function (mineralization), resulting in higher bone mineral density and
10147:
10127:
10102:
9949:
9894:
9849:
9827:
9736:
9731:
9701:
9686:
9681:
9646:
9536:
9491:
9471:
9349:
9343:
9247:
9235:
9195:
9176:
9152:
9136:
9046:
9042:
9016:
9002:
8955:
8950:
8945:
8935:
8905:
8875:
8870:
8850:
8787:
8708:
8688:
8673:
8668:
8613:
8563:
8464:
8405:
8338:
8333:
8310:
8248:
8223:
7889:
7805:
7032:
2074:
2006:
2002:
1763:
1743:
1722:
1529:
1485:
228:
125:
75:
8648:
8143:
5019:
3272:
2787:
2531:
2514:
1476:
first characterized in 1958 are water-soluble proteins located in the
931:
positive regulation of release of sequestered calcium ion into cytosol
10142:
10122:
10062:
10042:
9884:
9721:
9596:
9591:
9576:
9561:
9521:
9403:
9371:
9329:
9277:
9273:
9269:
9259:
9239:
9223:
9172:
9148:
9144:
9132:
9124:
9120:
9080:
9068:
9052:
9038:
9028:
9024:
8980:
8840:
8814:
8802:
8777:
8767:
8752:
8732:
8683:
8583:
8578:
8553:
8543:
8508:
8368:
8343:
8305:
8263:
7598:
7519:
5041:
4729:
2038:
1998:
1942:
1938:
1922:
1841:
1758:
1738:
1677:
1656:
1461:
1100:
295:
282:
194:
181:
83:
8088:
10013:
10003:
9706:
9566:
9486:
9481:
9414:
9231:
9168:
9164:
9128:
9116:
9088:
9084:
9072:
9064:
8994:
8782:
8772:
8618:
8603:
8588:
8523:
8518:
8363:
8273:
7823:
7801:
3522:
2014:
1626:
1616:
1552:
1532:
1481:
1406:
796:
positive regulation of G protein-coupled receptor signaling pathway
881:
positive regulation of inositol trisphosphate biosynthetic process
10168:
9914:
9726:
9626:
9616:
9611:
9391:
9335:
9325:
9217:
9092:
8900:
8895:
8797:
8762:
8693:
8593:
8442:
8410:
8348:
6894:
6604:
6599:
6594:
6589:
6584:
6579:
6574:
6569:
6564:
6559:
6554:
6549:
6544:
6539:
6534:
6529:
6524:
6519:
6215:
6210:
6205:
6200:
2693:
1829:
1780:
1540:
1536:
1493:
1489:
1450:
1212:
1167:
1085:
1081:
3458:
3422:
2687:
2358:
2309:"A conversation with Elwood Jensen. Interview by David D. Moore"
951:
positive regulation of release of cytochrome c from mitochondria
63:
10087:
10082:
9939:
9203:
9191:
9006:
8975:
8970:
8965:
8698:
8353:
7776:
7771:
7766:
7761:
7751:
7746:
7741:
7732:
7677:
7672:
7634:
7629:
7624:
7586:
7469:
7445:
7440:
7435:
7430:
7425:
7420:
7415:
7410:
7405:
7400:
7395:
7390:
7385:
7380:
7375:
7370:
7365:
7287:
7282:
7277:
7272:
7209:
7204:
7199:
7107:
7052:
7047:
7042:
7013:
6994:
6989:
6984:
6979:
6974:
6969:
6964:
6959:
6954:
6949:
6944:
6939:
6934:
6929:
6924:
6919:
6914:
6909:
6904:
6899:
6889:
6884:
6879:
6874:
6854:
6514:
6509:
6504:
6499:
6494:
6489:
6484:
6195:
6190:
6185:
6180:
6145:
5836:
5659:
5653:
5223:
5218:
5208:
5203:
4042:
3972:
2104:
1908:
1697:
1390:
1122:
510:
9433:
4271:"Obligatory role for GPER in cardiovascular aging and disease"
3762:
3643:
3261:
Journal of the
European Academy of Dermatology and Venereology
3020:
1061:
positive regulation of protein localization to plasma membrane
1046:
positive regulation of phosphatidylinositol 3-kinase signaling
10163:
10037:
9919:
9889:
9108:
8990:
8819:
7872:
7563:
7558:
7360:
7355:
7350:
7345:
7321:
7267:
7262:
7257:
7102:
7097:
7087:
7082:
7023:
6849:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6659:
6654:
6175:
6140:
5990:
5830:
5825:
5820:
5815:
5810:
5796:
5790:
5785:
5780:
5775:
5770:
5765:
5760:
5755:
5745:
5740:
5735:
5730:
5725:
5720:
5688:
5648:
5643:
5566:
5478:
5473:
5468:
5463:
5458:
5453:
5213:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
4080:
2773:
2215:
1775:
1651:
1572:
4670:
3113:
2412:
806:
positive regulation of extrinsic apoptotic signaling pathway
10183:
9964:
9874:
9243:
8998:
7867:
7862:
7857:
7852:
7847:
7842:
7837:
7832:
7827:
7245:
7238:
7233:
7228:
7037:
7027:
6649:
6644:
6639:
6634:
6294:
6170:
4463:
3678:
3322:
2113:
1795:
1460:. GPER binds to and is activated by the female sex hormone
1457:
7799:
3258:
3064:
2816:
1993:
GPER and ERα, but not ERβ, have been found to mediate the
976:
positive regulation of cytosolic calcium ion concentration
871:
nuclear fragmentation involved in apoptotic nuclear change
10018:
7062:
4962:. International Union of Basic and Clinical Pharmacology.
4901:
4809:
4268:
3840:
3801:
2915:
The
Journal of Steroid Biochemistry and Molecular Biology
2118:
1631:
1021:
positive regulation of transcription by RNA polymerase II
876:
positive regulation of endothelial cell apoptotic process
4552:. Springer Science & Business Media. pp. 165–.
3872:
3507:
1056:
intracellular steroid hormone receptor signaling pathway
1026:
positive regulation of uterine smooth muscle contraction
319:
4711:
4360:
4007:
3921:
3543:
2971:
2859:
2561:
2359:
Vrtačnik P, Ostanek B, Mencej-Bedrač S, Marc J (2014).
8334:
Epiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)
3713:
3511:
Cellular and Molecular Gastroenterology and Hepatology
2908:
2606:
2562:
Prossnitz ER, Arterburn JB, Sklar LA (February 2007).
2005:
in mice, while activation of ERβ has been found to be
2001:. Contrarily, activation of GPER has been found to be
4902:
Sahin N, Altun H, Kurutaş EB, Fındıklı E (May 2018).
3325:"GPER-1 acts as a tumor suppressor in ovarian cancer"
484:
4081:
Chimento A, Sirianni R, Casaburi I, Pezzi V (2014).
2649:
1977:
and as a result, blood pressure lowering effects of
1006:
positive regulation of cell population proliferation
831:
negative regulation of cell population proliferation
4464:Kastenberger I, Lutsch C, Schwarzer C (June 2012).
3873:Scaling AL, Prossnitz ER, Hathaway HJ (June 2014).
4760:
3293:
2959:"Entrez Gene: GPR30 G protein-coupled receptor 30"
2564:"GPR30: A G protein-coupled receptor for estrogen"
2257:
2159:
2157:
2155:
2138:
2136:
2134:
1988:
4131:
3373:
3067:"GPR30 predicts poor survival for ovarian cancer"
2084:
936:negative regulation of lipid biosynthetic process
911:negative regulation of protein kinase B signaling
861:positive regulation of neurotransmitter secretion
856:regulation of cytosolic calcium ion concentration
266:
165:
10259:
7938:
4572:
4541:
4539:
4414:
3681:Journal of Cancer Research and Clinical Oncology
3646:Journal of Cancer Research and Clinical Oncology
3594:
3544:Lappano R, Pisano A, Maggiolini M (6 May 2014).
3207:
2767:
4511:
4509:
4410:
4408:
4406:
4184:
4076:
4074:
3868:
3866:
3864:
2354:
2352:
2152:
2131:
1001:cellular response to mineralocorticoid stimulus
841:negative regulation of fat cell differentiation
16:Protein-coding gene in the species Homo sapiens
9438:Tooltip Selective estrogen receptor modulators
8793:Furostilbestrol (diethylstilbestrol difuroate)
8154:16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
4621:
3847:Regular and Young Investigator Award Abstracts
2512:
2408:
2406:
2404:
2253:
2251:
2249:
2247:
2164:GRCm38: Ensembl release 89: ENSMUSG00000053647
1484:hormones such as estradiol and several of its
786:positive regulation of protein phosphorylation
7984:3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
7924:
5005:
4960:IUPHAR Database of Receptors and Ion Channels
4573:Long N, Serey C, Sinchak K (September 2014).
4566:
4536:
3924:"GPER Function in Breast Cancer: An Overview"
3546:"GPER Function in Breast Cancer: An Overview"
3172:
2469:
991:cellular response to peptide hormone stimulus
8094:10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
4705:
4664:
4522:. Cambridge University Press. pp. 10–.
4506:
4457:
4403:
4354:
4311:
4233:
4227:
4178:
4071:
4036:
4001:
3966:
3915:
3861:
2965:
2600:
2555:
2506:
2463:
2349:
1941:and has been found to be essential for male
1071:modulation of chemical synaptic transmission
1041:mineralocorticoid receptor signaling pathway
1016:negative regulation of DNA metabolic process
1011:negative regulation of ERK1 and ERK2 cascade
906:G protein-coupled receptor signaling pathway
816:negative regulation of inflammatory response
801:positive regulation of ERK1 and ERK2 cascade
9969:Tooltip G protein-coupled estrogen receptor
8788:Fosfestrol (diethylstilbestrol diphosphate)
5036:
2726:
2401:
2300:
2244:
2143:GRCh38: Ensembl release 89: ENSG00000164850
1543:, nor other endogenous steroids, including
846:negative regulation of leukocyte activation
8931:Triphenylmethylethylene (triphenylpropene)
8255:, many others; via estrogenic metabolites)
8179:17α-Epiestriol (16α-hydroxy-17α-estradiol)
7931:
7917:
7134:
5012:
4998:
4980:United States National Library of Medicine
3922:Lappano R, Pisano A, Maggiolini M (2014).
2209:
1850:phosphatidylinositol (3,4,5)-trisphosphate
981:cellular response to tumor necrosis factor
826:steroid hormone mediated signaling pathway
7951:
4969:at the U.S. National Library of Medicine
4927:
4908:Bosnian Journal of Basic Medical Sciences
4835:
4786:
4737:
4688:
4647:
4598:
4545:
4489:
4440:
4386:
4294:
4210:
4185:Lindsey SH, Chappell MC (December 2011).
4157:
4108:
4098:
3949:
3939:
3898:
3739:
3620:
3571:
3561:
3484:
3399:
3350:
3340:
3307:
3235:
3225:
3149:
3139:
3090:
2997:
2934:
2885:
2750:
2583:
2530:
2438:
2384:
2324:
2283:
1981:. GPER also regulates components of the
1964:
1893:
926:negative regulation of cell cycle process
4978:This article incorporates text from the
4515:
2258:Prossnitz ER, Arterburn JB (July 2015).
1051:positive regulation of apoptotic process
961:positive regulation of insulin secretion
4956:"Estrogen (G protein coupled) Receptor"
4363:"In vivo effects of a GPR30 antagonist"
2862:"In vivo effects of a GPR30 antagonist"
986:cellular response to estradiol stimulus
10260:
6162:Luteinizing hormone/choriogonadotropin
2951:
2732:
2472:Trends in Endocrinology and Metabolism
2361:"The many faces of estrogen signaling"
2306:
1969:GPER is expressed in the blood vessel
1898:
996:positive regulation of gene expression
866:negative regulation of gene expression
770:hippocampal mossy fiber to CA3 synapse
7912:
7798:
7585:
7166:Brain-specific angiogenesis inhibitor
7133:
5035:
4993:
2326:10.1146/annurev-physiol-020911-153327
2069:, reduced body growth, and increased
1435:G protein-coupled estrogen receptor 1
971:positive regulation of cell migration
821:cellular response to glucose stimulus
740:integral component of plasma membrane
271:
232:
227:
170:
129:
124:
4718:Journal of Bone and Mineral Research
3024:Breast Cancer Research and Treatment
2653:Molecular and Cellular Endocrinology
2568:Molecular and Cellular Endocrinology
2045:, have been found to rapidly induce
946:positive regulation of neurogenesis
901:positive regulation of MAPK cascade
574:G protein-coupled receptor activity
13:
4895:
4754:
4615:
4433:10.1016/j.neuroscience.2008.11.028
4262:
4150:10.1161/HYPERTENSIONAHA.111.184606
4125:
3849:. BMJ Publishing Group Ltd: A790.
2902:
2853:
2513:Manavathi B, Kumar R (June 2006).
2052:
1949:. GPER has been found to modulate
700:intracellular anatomical structure
14:
10284:
9330:taleranol (teranol, β-zearalanol)
8245:metandienone (methandrostenolone)
4948:
3781:10.1200/JCO.2023.41.16_suppl.9543
1876:
1453:that in humans is encoded by the
851:apoptotic chromosome condensation
579:steroid hormone receptor activity
10240:Progesterone receptor modulators
9994:Afimoxifene (4-hydroxytamoxifen)
8876:Prinaberel (ERB-041, WAY-202041)
7515:Growth-hormone-releasing hormone
4546:Blaustein JD (8 December 2006).
2017:neurons in various parts of the
1929:knockout mice, but similarly to
1869:and developing follicles of the
1840:This protein is a member of the
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
9937:Coregulator-binding modulators:
8204:17β-Methyl-17α-dihydroequilenin
7475:Corticotropin-releasing hormone
4861:Frontiers in Neuroendocrinology
4852:
4803:
3855:10.1136/jitc-2022-sitc2022.0759
3834:
3795:
3756:
3707:
3672:
3637:
3588:
3537:
3501:
3452:
3416:
3367:
3316:
3287:
3252:
3201:
3166:
3107:
3058:
3014:
2810:
2643:
1989:Central nervous system activity
1524:GPER binds estradiol with high
1496:. These proteins belong to the
630:perinuclear region of cytoplasm
8768:Erteberel (SERBA-1, LY-500307)
6137:Gonadotropin-releasing hormone
4816:Science Translational Medicine
3438:10.1016/j.steroids.2013.07.007
2776:Journal of Cellular Physiology
2752:10.1016/j.steroids.2016.02.016
2621:10.1016/j.steroids.2011.12.023
2519:Journal of Cellular Physiology
2191:
2173:
2085:Role in neurological disorders
1955:hypothalamic-pituitary-gonadal
1951:gonadotropin-releasing hormone
1769:
725:endoplasmic reticulum membrane
680:integral component of membrane
511:More reference expression data
473:More reference expression data
1:
10225:Receptor/signaling modulators
8189:17α-Ethynyl-3β-androstanediol
8184:17α-Ethynyl-3α-androstanediol
7555:Vasoactive intestinal peptide
6425:Thyrotropin-releasing hormone
3987:10.1016/s1642-431x(12)60065-5
3820:10.1016/j.annonc.2023.09.2235
2708:10.1016/j.cellsig.2014.03.011
2124:
1907:in both normal and malignant
1818:
1443:G protein-coupled receptor 30
240:
139:
10235:Androgen receptor modulators
8539:Lynestrenol phenylpropionate
4828:10.1126/scitranslmed.aau5956
4516:Choleris E (11 April 2013).
4332:10.1097/FBP.0b013e32833db7e9
4045:Advances in Medical Sciences
3769:Journal of Clinical Oncology
3141:10.1371/journal.pone.0034672
2978:The Journal of Endocrinology
2013:of GPER, as well as ERβ, in
1467:
755:cytoplasmic vesicle membrane
7:
10273:G protein-coupled receptors
10268:Genes on human chromosome 7
10230:Estrogens and antiestrogens
9880:Oxabicycloheptene sulfonate
9567:Etacstil (GW-5638, DPC-974)
8743:Doisynoestrol (fenocycline)
8487:Ethinylestradiol 3-benzoate
7999:3β,5α-Dihydrolevonorgestrel
7994:3α,5α-Dihydrolevonorgestrel
6340:Prolactin-releasing peptide
5025:G protein-coupled receptors
4873:10.1016/j.yfrne.2019.100786
4640:10.1016/j.yhbeh.2016.12.013
4591:10.1016/j.yhbeh.2014.09.008
3329:Journal of Ovarian Research
3083:10.1016/j.ygyno.2009.05.015
2927:10.1016/j.jsbmb.2011.07.002
2313:Annual Review of Physiology
2093:
1846:G protein-coupled receptors
1835:
1590:
377:paraflocculus of cerebellum
10:
10289:
9947:Noncompetitive inhibitors:
9572:Ethamoxytriphetol (MER-25)
8733:Dimestrol (dianisylhexene)
8492:Ethinylestradiol sulfonate
4248:10.1016/j.phrs.2013.02.008
4203:10.1016/j.genm.2011.10.004
4087:Frontiers in Endocrinology
3928:Frontiers in Endocrinology
3550:Frontiers in Endocrinology
2100:Membrane estrogen receptor
1801:
1519:
1510:G protein-coupled receptor
941:nervous system development
564:signal transducer activity
544:estrogen receptor activity
10217:
10192:
10156:
9989:7β-Hydroxyepiandrosterone
9976:
9962:
9775:
9547:Desmethylchlorotrianisene
9428:
8726:Diethylstilbestrol esters
8679:Bisdehydrodoisynolic acid
8099:11β-Chloromethylestradiol
8074:7β-Hydroxyepiandrosterone
7963:
7956:Tooltip Estrogen receptor
7949:
7882:
7816:
7812:
7794:
7651:
7609:
7605:
7581:
7455:
7332:
7151:
7147:
7129:
7004:
6621:
6469:
6462:
5968:
5856:
5849:
5614:
5501:
5492:
5328:
5233:
5130:
5062:
5053:
5049:
5031:
4482:10.1007/s00213-011-2599-3
4287:10.1126/scisignal.aag0240
4057:10.2478/v10039-012-0005-y
4022:10.1016/j.lfs.2011.06.004
3891:10.1007/s12672-014-0174-1
3732:10.18632/oncotarget.25408
3693:10.1007/s00432-014-1620-8
3658:10.1007/s00432-014-1598-2
3227:10.1186/s12943-017-0654-3
3036:10.1007/s10549-014-2936-4
2665:10.1016/j.mce.2013.11.005
2576:10.1016/j.mce.2006.12.010
2484:10.1016/j.tem.2005.08.005
2199:"Mouse PubMed Reference:"
2181:"Human PubMed Reference:"
1421:
1416:
1412:
1405:
1389:
1383:Chr 5: 139.41 – 139.41 Mb
1370:
1355:
1351:
1326:
1322:
1315:
1300:
1296:
1267:
1263:
1256:
1243:
1239:
1224:
1220:
1211:
1198:
1194:
1179:
1175:
1166:
1153:
1149:
1134:
1130:
1121:
1106:
1099:
1095:
1079:
1031:neuronal action potential
529:
525:
508:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
10053:Fulvestrant (ICI-182780)
9870:Methylpiperidinopyrazole
9823:Fulvestrant (ICI-182780)
9306:Resorcylic acid lactones
8529:Hydroxyestrone diacetate
8465:Etamestrol (eptamestrol)
7661:Calcium-sensing receptor
7530:Methuselah-like proteins
4971:Medical Subject Headings
4920:10.17305/bjbms.2018.2942
4320:Behavioural Pharmacology
4236:Pharmacological Research
4100:10.3389/fendo.2014.00001
3941:10.3389/fendo.2014.00066
3601:Cell Death & Disease
3563:10.3389/fendo.2014.00066
3465:Cell Death & Disease
3380:Endocrine-Related Cancer
1983:renin–angiotensin system
1953:(GnRH) secretion in the
1571:with very low affinity.
1498:nuclear hormone receptor
675:dendritic spine membrane
381:tendon of biceps brachii
9364:Synthetic xenoestrogens
8921:Triphenylchloroethylene
8856:Methestrol dipropionate
8384:Polyestradiol phosphate
5807:Sphingosine-1-phosphate
5695:Hydroxycarboxylic acids
4367:Nature Chemical Biology
3309:10.7554/elife.31770.017
2866:Nature Chemical Biology
2819:Nature Chemical Biology
2440:10.1126/science.1106943
2264:Pharmacological Reviews
2023:paraventricular nucleus
1973:and is responsible for
1728:Protocatechuic aldehyde
705:presynaptic active zone
650:mitochondrial membranes
549:steroid hormone binding
435:internal carotid artery
423:external carotid artery
9457:4'-Hydroxynorendoxifen
9452:2-Phenylbenzothiophene
9326:zeranol (α-zearalanol)
9029:phlorizin (phloridzin)
8916:Triphenylbromoethylene
8815:ICI-85966 (Stilbostat)
8396:Estramustine phosphate
8269:Bolandiol dipropionate
7688:Metabotropic glutamate
3613:10.1038/cddis.2014.398
3477:10.1038/cddis.2013.275
3342:10.1186/1757-2215-6-51
2733:Barton M (July 2016).
2230:10.1006/geno.1998.5095
1965:Cardiovascular effects
1894:Role in normal tissues
1480:that are activated by
891:innate immune response
9637:Miproxifene phosphate
9462:27-Hydroxycholesterol
8926:Triphenyliodoethylene
8470:Ethinylandrostenediol
8433:Estrogenic substances
8421:Polyestriol phosphate
8289:Cloxestradiol acetate
5717:Lysophosphatidic acid
5021:Cell surface receptor
4628:Hormones and Behavior
4579:Hormones and Behavior
3879:Hormones & Cancer
3187:10.1089/dna.2016.3235
2276:10.1124/pr.114.009712
1567:bind to the receptor
1514:endoplasmic reticulum
1502:transcription factors
1376:Chr 7: 1.08 – 1.09 Mb
921:immune system process
896:inflammatory response
670:endoplasmic reticulum
451:epithelium of stomach
8951:WAY-204688 (SIM-688)
8763:ERB-196 (WAY-202196)
8714:Dienestrol diacetate
8453:Estrone methyl ether
8359:Esterified estrogens
8301:Conjugated estrogens
8194:17β-Dihydroequilenin
8169:17α-Dihydroequilenin
8109:15α-Hydroxyestradiol
8104:11β-Methoxyestradiol
8079:8,9-Dehydroestradiol
7642:Vomeronasal receptor
6612:Vomeronasal receptor
4779:10.1210/en.2013-1357
4690:10.1210/en.2008-0623
4379:10.1038/nchembio.168
3975:Reproductive Biology
3175:DNA and Cell Biology
3071:Gynecologic Oncology
2878:10.1038/nchembio.168
2570:. 265–266: 138–142.
2377:10.11613/BM.2014.035
2035:medial preoptic area
1579:and the antagonists
916:cell differentiation
760:presynaptic membrane
730:postsynaptic density
665:dendritic spine head
397:right adrenal cortex
365:middle frontal gyrus
234:Chromosome 5 (mouse)
132:Chromosome 7 (human)
10118:Propylpyrazoletriol
10033:Diarylpropionitrile
8881:Propylpyrazoletriol
8738:Dimethylstilbestrol
8704:Diarylpropionitrile
8514:Etynodiol diacetate
8214:Abiraterone acetate
8124:16α-Fluoroestradiol
7535:Parathyroid hormone
5495:signaling molecules
3726:(40): 25946–25956.
3392:10.1530/erc-14-0402
3132:2012PLoSO...734672C
2990:10.1677/JOE-09-0066
2831:10.1038/nchembio775
2696:Cellular Signalling
2431:2005Sci...307.1625R
2425:(5715): 1625–1630.
1945:, specifically, in
1903:Estradiol produces
1899:Reproductive tissue
1733:Propylpyrazoletriol
1646:Diarylpropionitrile
1036:signal transduction
765:cytoplasmic vesicle
620:trans-Golgi network
447:trigeminal ganglion
385:right lobe of liver
10200:Diethylstilbestrol
9984:2-Methoxyestradiol
9915:TAS-108 (SR-16234)
9865:Methylepitiostanol
9803:EM-800 (SCH-57050)
9727:TAS-108 (SR-16234)
9447:2-Phenylbenzofuran
9061:8-prenylnaringenin
8721:Diethylstilbestrol
8379:Lipoidal estradiol
8354:ERA-63 (ORG-37663)
8296:Conjugated estriol
8241:methyltestosterone
8199:17β-Dihydroequilin
8174:17α-Dihydroequilin
8149:16β-Hydroxyestrone
8134:16α-Hydroxyestrone
8084:8,9-Dehydroestrone
8069:7α-Methylestradiol
8044:4-Methoxyestradiol
8034:4-Hydroxyestradiol
8009:3β-Hydroxytibolone
8004:3α-Hydroxytibolone
7974:2-Hydroxyestradiol
7684:Glutamate receptor
7069:Protease-activated
4982:, which is in the
4470:Psychopharmacology
4016:(15–16): 584–587.
3808:Annals of Oncology
3775:(16_suppl): 9543.
2027:supraoptic nucleus
2009:. There is a high
1935:breast development
1905:cell proliferation
1808:Diethylstilbestrol
1597:2-Methoxyestradiol
1506:gene transcription
1474:estrogen receptors
1201:ENSMUSG00000053647
779:Biological process
685:recycling endosome
588:Cellular component
537:Molecular function
10253:
10252:
10245:List of estrogens
10213:
10212:
9958:
9957:
9798:Cytestrol acetate
9021:isoliquiritigenin
8963:Unknown/unsorted:
8649:β-LGND2 (GTx-878)
8229:Anabolic steroids
8139:16α-Iodoestradiol
8029:4-Fluoroestradiol
8024:4-Androstenedione
8014:3β-Androstanediol
7989:3α-Androstanediol
7940:Estrogen receptor
7906:
7905:
7902:
7901:
7898:
7897:
7790:
7789:
7786:
7785:
7577:
7576:
7573:
7572:
7125:
7124:
7121:
7120:
7117:
7116:
6458:
6457:
5845:
5844:
5488:
5487:
4822:(528): eaau5956.
4773:(11): 4136–4145.
4559:978-0-387-30362-8
4529:978-0-521-19035-0
4275:Science Signaling
3517:(4): 868–880.e1.
3432:(11): 1087–1091.
3273:10.1111/jdv.14304
2788:10.1002/jcp.22284
2615:(10): 1002–1006.
2532:10.1002/jcp.20551
2307:Jensen E (2012).
2067:glucose tolerance
2031:oxytocin receptor
1997:-like effects of
1912:epithelial tissue
1528:though not other
1478:interior of cells
1441:), also known as
1432:
1431:
1428:
1427:
1401:
1400:
1366:
1365:
1345:
1344:
1311:
1310:
1290:
1289:
1252:
1251:
1233:
1232:
1207:
1206:
1188:
1187:
1162:
1161:
1143:
1142:
1091:
1090:
836:apoptotic process
554:chromatin binding
521:
520:
517:
516:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:GPER1 - orthologs
10280:
10112:2,2',5'-PCB-4-OH
10048:Ethinylestradiol
9974:
9973:
9970:
9966:
9707:Rimostil (P-081)
9517:Chlorotrianisene
9439:
9435:
9214:Metalloestrogens
8993:-related (e.g.,
8808:Hexestrol esters
8482:Ethinylestradiol
8374:Estradiol esters
8129:16α-Hydroxy-DHEA
8114:16-Ketoestradiol
8054:5-Androstenediol
8049:4-Methoxyestrone
8039:4-Hydroxyestrone
8019:4-Androstenediol
7979:2-Hydroxyestrone
7961:
7960:
7957:
7953:
7933:
7926:
7919:
7910:
7909:
7814:
7813:
7796:
7795:
7607:
7606:
7583:
7582:
7149:
7148:
7131:
7130:
6467:
6466:
5854:
5853:
5752:Lysophospholipid
5499:
5498:
5060:
5059:
5055:Neurotransmitter
5051:
5050:
5033:
5032:
5014:
5007:
5000:
4991:
4990:
4963:
4942:
4941:
4931:
4899:
4893:
4892:
4856:
4850:
4849:
4839:
4807:
4801:
4800:
4790:
4758:
4752:
4751:
4741:
4730:10.1002/jbmr.209
4709:
4703:
4702:
4692:
4668:
4662:
4661:
4651:
4619:
4613:
4612:
4602:
4570:
4564:
4563:
4543:
4534:
4533:
4513:
4504:
4503:
4493:
4461:
4455:
4454:
4444:
4427:(4): 1599–1607.
4412:
4401:
4400:
4390:
4358:
4352:
4351:
4326:(5–6): 451–464.
4315:
4309:
4308:
4298:
4266:
4260:
4259:
4231:
4225:
4224:
4214:
4182:
4176:
4175:
4161:
4129:
4123:
4122:
4112:
4102:
4078:
4069:
4068:
4040:
4034:
4033:
4005:
3999:
3998:
3970:
3964:
3963:
3953:
3943:
3919:
3913:
3912:
3902:
3870:
3859:
3858:
3838:
3832:
3831:
3799:
3793:
3792:
3760:
3754:
3753:
3743:
3711:
3705:
3704:
3676:
3670:
3669:
3641:
3635:
3634:
3624:
3592:
3586:
3585:
3575:
3565:
3541:
3535:
3534:
3505:
3499:
3498:
3488:
3456:
3450:
3449:
3420:
3414:
3413:
3403:
3371:
3365:
3364:
3354:
3344:
3320:
3314:
3313:
3311:
3291:
3285:
3284:
3267:(9): 1453–1461.
3256:
3250:
3249:
3239:
3229:
3214:Molecular Cancer
3205:
3199:
3198:
3170:
3164:
3163:
3153:
3143:
3111:
3105:
3104:
3094:
3062:
3056:
3055:
3018:
3012:
3011:
3001:
2969:
2963:
2962:
2955:
2949:
2948:
2938:
2921:(3–5): 358–366.
2906:
2900:
2899:
2889:
2857:
2851:
2850:
2814:
2808:
2807:
2771:
2765:
2764:
2754:
2730:
2724:
2723:
2702:(7): 1466–1475.
2691:
2685:
2684:
2647:
2641:
2640:
2604:
2598:
2597:
2587:
2559:
2553:
2552:
2534:
2510:
2504:
2503:
2467:
2461:
2460:
2442:
2410:
2399:
2398:
2388:
2365:Biochemia Medica
2356:
2347:
2346:
2328:
2304:
2298:
2297:
2287:
2255:
2242:
2241:
2213:
2207:
2206:
2195:
2189:
2188:
2177:
2171:
2161:
2150:
2140:
2021:, including the
1914:. However, GPER
1844:-like family of
1662:Ethynylestradiol
1602:2,2',5'-PCB-4-OH
1414:
1413:
1385:
1378:
1361:
1349:
1348:
1340:
1320:
1319:
1316:RefSeq (protein)
1306:
1294:
1293:
1285:
1261:
1260:
1237:
1236:
1218:
1217:
1192:
1191:
1173:
1172:
1147:
1146:
1128:
1127:
1097:
1096:
655:keratin filament
605:nuclear envelope
527:
526:
513:
504:
497:
490:
489:
475:
455:substantia nigra
415:
413:Top expressed in
408:
407:
353:
351:Top expressed in
346:
345:
325:
324:
308:
307:
298:
285:
274:
259:
252:
246:
235:
223:
207:
206:
197:
184:
173:
158:
151:
145:
134:
120:
104:
103:
98:
49:
42:
21:
20:
10288:
10287:
10283:
10282:
10281:
10279:
10278:
10277:
10258:
10257:
10254:
10249:
10209:
10188:
10152:
9968:
9954:
9788:7β-Hydroxy-DHEA
9771:
9607:Levormeloxifene
9437:
9430:
9424:
9340:deoxymiroestrol
9208:-hinokiresinol)
8846:Methallenestril
8748:Doisynolic acid
8549:Methylestradiol
8064:7α-Hydroxy-DHEA
7955:
7945:
7937:
7907:
7894:
7878:
7808:
7782:
7669:
7647:
7601:
7569:
7451:
7328:
7143:
7113:
7000:
6617:
6454:
6060:Cholecystokinin
5964:
5841:
5670:Free fatty acid
5610:
5494:
5493:Metabolites and
5484:
5324:
5229:
5126:
5045:
5027:
5018:
4954:
4951:
4946:
4945:
4900:
4896:
4857:
4853:
4808:
4804:
4759:
4755:
4710:
4706:
4669:
4665:
4620:
4616:
4571:
4567:
4560:
4544:
4537:
4530:
4514:
4507:
4462:
4458:
4413:
4404:
4359:
4355:
4316:
4312:
4267:
4263:
4232:
4228:
4191:Gender Medicine
4183:
4179:
4130:
4126:
4079:
4072:
4041:
4037:
4006:
4002:
3971:
3967:
3920:
3916:
3871:
3862:
3839:
3835:
3800:
3796:
3761:
3757:
3712:
3708:
3677:
3673:
3642:
3638:
3593:
3589:
3542:
3538:
3506:
3502:
3457:
3453:
3421:
3417:
3372:
3368:
3321:
3317:
3292:
3288:
3257:
3253:
3206:
3202:
3171:
3167:
3112:
3108:
3063:
3059:
3019:
3015:
2970:
2966:
2957:
2956:
2952:
2907:
2903:
2858:
2854:
2815:
2811:
2772:
2768:
2731:
2727:
2692:
2688:
2648:
2644:
2605:
2601:
2560:
2556:
2511:
2507:
2468:
2464:
2411:
2402:
2357:
2350:
2305:
2301:
2256:
2245:
2214:
2210:
2197:
2196:
2192:
2179:
2178:
2174:
2162:
2153:
2141:
2132:
2127:
2108:
2096:
2087:
2079:trabecular bone
2055:
2053:Metabolic roles
1991:
1967:
1947:spermatogenesis
1901:
1896:
1879:
1863:adrenal medulla
1859:pituitary gland
1838:
1821:
1804:
1772:
1593:
1522:
1470:
1423:View/Edit Mouse
1418:View/Edit Human
1381:
1374:
1371:Location (UCSC)
1357:
1336:
1332:
1328:
1302:
1281:
1277:
1273:
1269:
1182:ENSG00000164850
1075:
774:
695:plasma membrane
690:Golgi apparatus
660:dendritic shaft
645:cell projection
583:
569:steroid binding
559:protein binding
509:
499:
498:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
361:body of stomach
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
10286:
10276:
10275:
10270:
10251:
10250:
10248:
10247:
10242:
10237:
10232:
10227:
10222:
10218:
10215:
10214:
10211:
10210:
10208:
10207:
10202:
10196:
10194:
10190:
10189:
10187:
10186:
10181:
10176:
10171:
10166:
10160:
10158:
10154:
10153:
10151:
10150:
10145:
10140:
10135:
10130:
10125:
10120:
10115:
10105:
10100:
10095:
10090:
10085:
10080:
10078:Hydroxytyrosol
10075:
10070:
10065:
10060:
10055:
10050:
10045:
10040:
10035:
10030:
10016:
10011:
10006:
10001:
9996:
9991:
9986:
9980:
9978:
9971:
9960:
9959:
9956:
9955:
9953:
9952:
9943:
9942:
9933:
9932:
9927:
9922:
9917:
9912:
9907:
9902:
9897:
9892:
9887:
9882:
9877:
9872:
9867:
9862:
9857:
9852:
9847:
9825:
9820:
9815:
9810:
9805:
9800:
9795:
9793:Chloroindazole
9790:
9785:
9779:
9777:
9773:
9772:
9770:
9769:
9764:
9759:
9754:
9749:
9744:
9739:
9734:
9729:
9724:
9719:
9714:
9712:Spironolactone
9709:
9704:
9699:
9694:
9689:
9684:
9679:
9674:
9669:
9664:
9659:
9654:
9649:
9644:
9639:
9634:
9629:
9624:
9619:
9614:
9609:
9604:
9599:
9594:
9589:
9584:
9579:
9574:
9569:
9564:
9559:
9554:
9549:
9544:
9539:
9534:
9529:
9524:
9519:
9514:
9509:
9504:
9499:
9494:
9489:
9484:
9479:
9474:
9469:
9464:
9459:
9454:
9449:
9443:
9441:
9426:
9425:
9423:
9422:
9413:Others (e.g.,
9411:
9361:
9347:
9333:
9303:
9285:
9263:
9221:
9211:
9189:
9184:
9141:liquiritigenin
9050:
9036:
9014:
8988:Xenoestrogens:
8984:
8983:
8978:
8973:
8968:
8959:
8958:
8953:
8948:
8943:
8938:
8933:
8928:
8923:
8918:
8913:
8908:
8903:
8898:
8893:
8888:
8883:
8878:
8873:
8868:
8863:
8861:Paroxypropione
8858:
8853:
8848:
8843:
8838:
8830:
8822:
8817:
8812:
8811:
8810:
8800:
8795:
8790:
8785:
8780:
8775:
8773:Estrobin (DBE)
8770:
8765:
8760:
8755:
8750:
8745:
8740:
8735:
8730:
8729:
8728:
8718:
8717:
8716:
8706:
8701:
8696:
8691:
8686:
8681:
8676:
8671:
8666:
8664:Allenolic acid
8661:
8656:
8651:
8646:
8641:
8636:
8631:
8622:
8621:
8616:
8611:
8606:
8601:
8596:
8591:
8586:
8581:
8576:
8571:
8569:Norethisterone
8566:
8561:
8559:Mytatrienediol
8556:
8551:
8546:
8541:
8536:
8531:
8526:
8521:
8516:
8511:
8506:
8504:Ethylestradiol
8501:
8499:Ethinylestriol
8496:
8495:
8494:
8489:
8479:
8478:
8477:
8467:
8462:
8461:
8460:
8455:
8450:
8448:Estrone esters
8440:
8435:
8430:
8425:
8424:
8423:
8418:
8416:Estriol esters
8408:
8403:
8401:Estrapronicate
8398:
8393:
8388:
8387:
8386:
8381:
8376:
8366:
8361:
8356:
8351:
8346:
8341:
8336:
8331:
8323:
8318:
8313:
8308:
8303:
8298:
8293:
8292:
8291:
8281:
8276:
8271:
8266:
8261:
8256:
8226:
8221:
8219:Alestramustine
8216:
8211:
8206:
8201:
8196:
8191:
8186:
8181:
8176:
8171:
8166:
8156:
8151:
8146:
8141:
8136:
8131:
8126:
8121:
8119:16-Ketoestrone
8116:
8111:
8106:
8101:
8096:
8091:
8086:
8081:
8076:
8071:
8066:
8061:
8056:
8051:
8046:
8041:
8036:
8031:
8026:
8021:
8016:
8011:
8006:
8001:
7996:
7991:
7986:
7981:
7976:
7967:
7965:
7958:
7947:
7946:
7936:
7935:
7928:
7921:
7913:
7904:
7903:
7900:
7899:
7896:
7895:
7893:
7892:
7886:
7884:
7880:
7879:
7877:
7876:
7870:
7865:
7860:
7855:
7850:
7845:
7840:
7835:
7830:
7820:
7818:
7810:
7809:
7792:
7791:
7788:
7787:
7784:
7783:
7781:
7780:
7774:
7769:
7764:
7755:
7749:
7744:
7735:
7730:
7724:
7719:
7714:
7709:
7704:
7699:
7694:
7681:
7675:
7667:
7663:
7657:
7655:
7649:
7648:
7646:
7645:
7639:
7638:
7637:
7632:
7627:
7616:
7614:
7603:
7602:
7579:
7578:
7575:
7574:
7571:
7570:
7568:
7567:
7561:
7552:
7547:
7541:
7532:
7527:
7522:
7517:
7512:
7506:
7501:
7496:
7487:
7481:
7472:
7467:
7461:
7459:
7453:
7452:
7450:
7449:
7443:
7438:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7388:
7383:
7378:
7373:
7368:
7363:
7358:
7353:
7348:
7338:
7336:
7330:
7329:
7327:
7326:
7325:
7324:
7319:
7318:
7317:
7312:
7307:
7292:
7291:
7290:
7285:
7280:
7275:
7270:
7265:
7260:
7250:
7249:
7248:
7243:
7242:
7241:
7236:
7231:
7216:
7215:
7214:
7213:
7212:
7207:
7202:
7187:
7186:
7185:
7184:
7183:
7178:
7173:
7157:
7155:
7145:
7144:
7127:
7126:
7123:
7122:
7119:
7118:
7115:
7114:
7112:
7111:
7105:
7100:
7091:
7085:
7080:
7075:
7066:
7060:
7055:
7050:
7045:
7040:
7035:
7030:
7021:
7016:
7014:Adrenomedullin
7010:
7008:
7002:
7001:
6999:
6998:
6992:
6987:
6982:
6977:
6972:
6967:
6962:
6957:
6952:
6947:
6942:
6937:
6932:
6927:
6922:
6917:
6912:
6907:
6902:
6897:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6672:
6667:
6662:
6657:
6652:
6647:
6642:
6637:
6627:
6625:
6619:
6618:
6616:
6615:
6609:
6608:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6476:
6474:
6464:
6460:
6459:
6456:
6455:
6453:
6452:
6446:
6441:
6432:
6427:
6422:
6417:
6411:
6406:
6397:
6391:
6386:
6381:
6376:
6367:
6361:
6356:
6351:
6342:
6337:
6331:
6322:
6317:
6311:
6302:
6288:
6283:
6278:
6269:
6264:
6258:
6249:
6243:
6238:
6233:
6228:
6219:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6178:
6173:
6164:
6159:
6154:
6149:
6143:
6134:
6128:
6123:
6114:
6109:
6103:
6098:
6092:Formyl peptide
6089:
6088:
6087:
6082:
6072:
6066:
6057:
6052:
6051:
6050:
6044:
6035:
6029:
6024:
6014:
6009:
6003:
5994:
5988:
5982:
5972:
5970:
5966:
5965:
5963:
5962:
5956:
5947:
5941:
5932:
5923:
5917:
5912:
5907:
5898:
5893:
5887:
5878:
5872:
5862:
5860:
5851:
5847:
5846:
5843:
5842:
5840:
5839:
5834:
5828:
5823:
5818:
5813:
5804:
5799:
5794:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5749:
5743:
5738:
5733:
5728:
5723:
5714:
5713:
5712:
5707:
5702:
5692:
5686:
5681:
5676:
5667:
5662:
5657:
5651:
5646:
5633:
5624:
5618:
5616:
5612:
5611:
5609:
5608:
5603:
5598:
5597:
5596:
5587:
5582:
5577:
5564:
5550:
5545:
5540:
5539:
5538:
5533:
5523:
5517:
5507:
5505:
5496:
5490:
5489:
5486:
5485:
5483:
5482:
5476:
5471:
5466:
5461:
5456:
5447:
5441:
5436:
5427:
5426:
5425:
5420:
5415:
5410:
5400:
5395:
5394:
5393:
5388:
5383:
5378:
5373:
5363:
5357:
5352:
5347:
5342:
5332:
5330:
5326:
5325:
5323:
5322:
5316:
5311:
5306:
5297:
5291:
5286:
5277:
5271:
5266:
5261:
5256:
5239:
5237:
5231:
5230:
5228:
5227:
5221:
5216:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
5176:
5171:
5162:
5156:
5151:
5146:
5136:
5134:
5128:
5127:
5125:
5124:
5119:
5114:
5109:
5103:
5098:
5089:
5083:
5078:
5068:
5066:
5057:
5047:
5046:
5029:
5028:
5017:
5016:
5009:
5002:
4994:
4975:
4974:
4964:
4950:
4949:External links
4947:
4944:
4943:
4914:(2): 126–131.
4894:
4851:
4802:
4753:
4724:(2): 298–307.
4704:
4683:(2): 687–698.
4663:
4614:
4585:(4): 663–666.
4565:
4558:
4535:
4528:
4505:
4476:(3): 527–535.
4456:
4402:
4373:(6): 421–427.
4353:
4310:
4281:(452): ra105.
4261:
4226:
4197:(6): 343–354.
4177:
4144:(2): 507–512.
4124:
4070:
4035:
4000:
3981:(3): 174–193.
3965:
3914:
3885:(3): 146–160.
3860:
3833:
3794:
3755:
3706:
3687:(5): 713–723.
3671:
3652:(4): 663–671.
3636:
3587:
3536:
3523:10.1101/365668
3500:
3451:
3415:
3386:(6): 903–914.
3366:
3315:
3286:
3251:
3200:
3181:(8): 434–442.
3165:
3106:
3077:(3): 465–471.
3057:
3013:
2984:(2): 223–236.
2964:
2950:
2901:
2872:(6): 421–427.
2852:
2825:(4): 207–212.
2809:
2782:(3): 792–800.
2766:
2725:
2686:
2659:(2): 950–959.
2642:
2599:
2554:
2525:(3): 594–604.
2505:
2478:(8): 362–367.
2462:
2400:
2371:(3): 329–342.
2348:
2299:
2270:(3): 505–540.
2243:
2224:(2): 310–313.
2208:
2190:
2172:
2151:
2129:
2128:
2126:
2123:
2122:
2121:
2116:
2111:
2106:
2102:
2095:
2092:
2086:
2083:
2071:blood pressure
2054:
2051:
1995:antidepressant
1990:
1987:
1966:
1963:
1918:show no overt
1900:
1897:
1895:
1892:
1878:
1877:Role in cancer
1875:
1867:kidney medulla
1837:
1834:
1833:
1832:
1827:
1820:
1817:
1816:
1815:
1810:
1803:
1800:
1799:
1798:
1793:
1788:
1783:
1778:
1771:
1768:
1767:
1766:
1761:
1756:
1751:
1746:
1741:
1736:
1730:
1725:
1720:
1715:
1710:
1705:
1700:
1695:
1693:Hydroxytyrosol
1690:
1685:
1680:
1675:
1670:
1664:
1659:
1654:
1649:
1643:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1592:
1589:
1521:
1518:
1504:that regulate
1472:The classical
1469:
1466:
1430:
1429:
1426:
1425:
1420:
1410:
1409:
1403:
1402:
1399:
1398:
1396:
1394:
1387:
1386:
1379:
1372:
1368:
1367:
1364:
1363:
1353:
1352:
1346:
1343:
1342:
1324:
1323:
1317:
1313:
1312:
1309:
1308:
1298:
1297:
1291:
1288:
1287:
1265:
1264:
1258:
1254:
1253:
1250:
1249:
1241:
1240:
1234:
1231:
1230:
1222:
1221:
1215:
1209:
1208:
1205:
1204:
1196:
1195:
1189:
1186:
1185:
1177:
1176:
1170:
1164:
1163:
1160:
1159:
1151:
1150:
1144:
1141:
1140:
1132:
1131:
1125:
1119:
1118:
1113:
1108:
1104:
1103:
1093:
1092:
1089:
1088:
1077:
1076:
1074:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
782:
780:
776:
775:
773:
772:
767:
762:
757:
752:
747:
742:
737:
735:Golgi membrane
732:
727:
722:
717:
715:early endosome
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
591:
589:
585:
584:
582:
581:
576:
571:
566:
561:
556:
551:
546:
540:
538:
534:
533:
523:
522:
519:
518:
515:
514:
506:
505:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
9:
6:
4:
3:
2:
10285:
10274:
10271:
10269:
10266:
10265:
10263:
10256:
10246:
10243:
10241:
10238:
10236:
10233:
10231:
10228:
10226:
10223:
10220:
10219:
10216:
10206:
10203:
10201:
10198:
10197:
10195:
10191:
10185:
10182:
10180:
10177:
10175:
10172:
10170:
10167:
10165:
10162:
10161:
10159:
10155:
10149:
10146:
10144:
10141:
10139:
10136:
10134:
10131:
10129:
10126:
10124:
10121:
10119:
10116:
10113:
10109:
10106:
10104:
10101:
10099:
10096:
10094:
10091:
10089:
10086:
10084:
10081:
10079:
10076:
10074:
10071:
10069:
10066:
10064:
10061:
10059:
10056:
10054:
10051:
10049:
10046:
10044:
10041:
10039:
10036:
10034:
10031:
10028:
10024:
10020:
10017:
10015:
10012:
10010:
10007:
10005:
10002:
10000:
9997:
9995:
9992:
9990:
9987:
9985:
9982:
9981:
9979:
9975:
9972:
9967:
9961:
9951:
9948:
9945:
9944:
9941:
9938:
9935:
9934:
9931:
9928:
9926:
9923:
9921:
9918:
9916:
9913:
9911:
9908:
9906:
9903:
9901:
9898:
9896:
9893:
9891:
9888:
9886:
9883:
9881:
9878:
9876:
9873:
9871:
9868:
9866:
9863:
9861:
9858:
9856:
9853:
9851:
9848:
9845:
9841:
9837:
9833:
9829:
9826:
9824:
9821:
9819:
9816:
9814:
9811:
9809:
9806:
9804:
9801:
9799:
9796:
9794:
9791:
9789:
9786:
9784:
9781:
9780:
9778:
9774:
9768:
9765:
9763:
9760:
9758:
9755:
9753:
9750:
9748:
9745:
9743:
9740:
9738:
9735:
9733:
9730:
9728:
9725:
9723:
9720:
9718:
9715:
9713:
9710:
9708:
9705:
9703:
9700:
9698:
9695:
9693:
9692:Pipendoxifene
9690:
9688:
9685:
9683:
9680:
9678:
9675:
9673:
9670:
9668:
9665:
9663:
9660:
9658:
9655:
9653:
9650:
9648:
9645:
9643:
9640:
9638:
9635:
9633:
9630:
9628:
9625:
9623:
9620:
9618:
9615:
9613:
9610:
9608:
9605:
9603:
9600:
9598:
9595:
9593:
9590:
9588:
9585:
9583:
9580:
9578:
9575:
9573:
9570:
9568:
9565:
9563:
9560:
9558:
9555:
9553:
9550:
9548:
9545:
9543:
9540:
9538:
9535:
9533:
9530:
9528:
9527:Clomifenoxide
9525:
9523:
9520:
9518:
9515:
9513:
9510:
9508:
9505:
9503:
9502:Brilanestrant
9500:
9498:
9495:
9493:
9490:
9488:
9485:
9483:
9480:
9478:
9475:
9473:
9470:
9468:
9465:
9463:
9460:
9458:
9455:
9453:
9450:
9448:
9445:
9444:
9442:
9436:
9427:
9420:
9416:
9412:
9409:
9405:
9401:
9397:
9393:
9389:
9385:
9381:
9377:
9373:
9369:
9365:
9362:
9359:
9355:
9351:
9348:
9345:
9341:
9338:-like (e.g.,
9337:
9334:
9331:
9327:
9323:
9319:
9315:
9311:
9307:
9304:
9301:
9297:
9293:
9289:
9286:
9283:
9282:guggulsterone
9279:
9275:
9271:
9267:
9266:Phytosteroids
9264:
9261:
9257:
9253:
9249:
9245:
9241:
9237:
9233:
9229:
9225:
9222:
9219:
9215:
9212:
9209:
9207:
9201:
9200:enterolactone
9197:
9193:
9190:
9188:
9185:
9182:
9178:
9174:
9170:
9166:
9162:
9158:
9154:
9150:
9146:
9142:
9138:
9134:
9130:
9126:
9122:
9118:
9114:
9110:
9106:
9102:
9098:
9094:
9090:
9086:
9082:
9078:
9074:
9070:
9066:
9062:
9058:
9054:
9051:
9048:
9044:
9040:
9037:
9034:
9033:wedelolactone
9030:
9026:
9022:
9018:
9015:
9012:
9011:photoanethole
9008:
9004:
9000:
8996:
8992:
8989:
8986:
8985:
8982:
8979:
8977:
8974:
8972:
8969:
8967:
8964:
8961:
8960:
8957:
8954:
8952:
8949:
8947:
8944:
8942:
8939:
8937:
8934:
8932:
8929:
8927:
8924:
8922:
8919:
8917:
8914:
8912:
8909:
8907:
8904:
8902:
8899:
8897:
8894:
8892:
8889:
8887:
8884:
8882:
8879:
8877:
8874:
8872:
8869:
8867:
8866:Pentafluranol
8864:
8862:
8859:
8857:
8854:
8852:
8849:
8847:
8844:
8842:
8839:
8837:
8835:
8831:
8829:
8827:
8823:
8821:
8818:
8816:
8813:
8809:
8806:
8805:
8804:
8801:
8799:
8796:
8794:
8791:
8789:
8786:
8784:
8781:
8779:
8776:
8774:
8771:
8769:
8766:
8764:
8761:
8759:
8756:
8754:
8751:
8749:
8746:
8744:
8741:
8739:
8736:
8734:
8731:
8727:
8724:
8723:
8722:
8719:
8715:
8712:
8711:
8710:
8707:
8705:
8702:
8700:
8697:
8695:
8692:
8690:
8687:
8685:
8682:
8680:
8677:
8675:
8672:
8670:
8667:
8665:
8662:
8660:
8657:
8655:
8652:
8650:
8647:
8645:
8642:
8640:
8637:
8635:
8632:
8630:
8627:
8626:Nonsteroidal:
8624:
8623:
8620:
8617:
8615:
8612:
8610:
8607:
8605:
8602:
8600:
8597:
8595:
8592:
8590:
8587:
8585:
8582:
8580:
8577:
8575:
8572:
8570:
8567:
8565:
8562:
8560:
8557:
8555:
8552:
8550:
8547:
8545:
8542:
8540:
8537:
8535:
8532:
8530:
8527:
8525:
8522:
8520:
8517:
8515:
8512:
8510:
8507:
8505:
8502:
8500:
8497:
8493:
8490:
8488:
8485:
8484:
8483:
8480:
8476:
8475:Ethandrostate
8473:
8472:
8471:
8468:
8466:
8463:
8459:
8456:
8454:
8451:
8449:
8446:
8445:
8444:
8441:
8439:
8436:
8434:
8431:
8429:
8426:
8422:
8419:
8417:
8414:
8413:
8412:
8409:
8407:
8404:
8402:
8399:
8397:
8394:
8392:
8389:
8385:
8382:
8380:
8377:
8375:
8372:
8371:
8370:
8367:
8365:
8362:
8360:
8357:
8355:
8352:
8350:
8347:
8345:
8342:
8340:
8337:
8335:
8332:
8330:
8328:
8324:
8322:
8319:
8317:
8314:
8312:
8309:
8307:
8304:
8302:
8299:
8297:
8294:
8290:
8287:
8286:
8285:
8284:Cloxestradiol
8282:
8280:
8277:
8275:
8272:
8270:
8267:
8265:
8262:
8260:
8257:
8254:
8250:
8246:
8242:
8238:
8234:
8230:
8227:
8225:
8222:
8220:
8217:
8215:
8212:
8210:
8207:
8205:
8202:
8200:
8197:
8195:
8192:
8190:
8187:
8185:
8182:
8180:
8177:
8175:
8172:
8170:
8167:
8164:
8160:
8159:17α-Estradiol
8157:
8155:
8152:
8150:
8147:
8145:
8142:
8140:
8137:
8135:
8132:
8130:
8127:
8125:
8122:
8120:
8117:
8115:
8112:
8110:
8107:
8105:
8102:
8100:
8097:
8095:
8092:
8090:
8087:
8085:
8082:
8080:
8077:
8075:
8072:
8070:
8067:
8065:
8062:
8060:
8057:
8055:
8052:
8050:
8047:
8045:
8042:
8040:
8037:
8035:
8032:
8030:
8027:
8025:
8022:
8020:
8017:
8015:
8012:
8010:
8007:
8005:
8002:
8000:
7997:
7995:
7992:
7990:
7987:
7985:
7982:
7980:
7977:
7975:
7972:
7969:
7968:
7966:
7962:
7959:
7954:
7948:
7944:
7941:
7934:
7929:
7927:
7922:
7920:
7915:
7914:
7911:
7891:
7888:
7887:
7885:
7881:
7874:
7871:
7869:
7866:
7864:
7861:
7859:
7856:
7854:
7851:
7849:
7846:
7844:
7841:
7839:
7836:
7834:
7831:
7829:
7825:
7822:
7821:
7819:
7815:
7811:
7807:
7803:
7797:
7793:
7778:
7775:
7773:
7770:
7768:
7765:
7763:
7759:
7756:
7753:
7750:
7748:
7745:
7743:
7739:
7736:
7734:
7731:
7728:
7725:
7723:
7720:
7718:
7715:
7713:
7710:
7708:
7705:
7703:
7700:
7698:
7695:
7693:
7689:
7685:
7682:
7679:
7676:
7674:
7670:
7664:
7662:
7659:
7658:
7656:
7654:
7650:
7643:
7640:
7636:
7633:
7631:
7628:
7626:
7623:
7622:
7621:
7618:
7617:
7615:
7612:
7608:
7604:
7600:
7596:
7593:
7589:
7584:
7580:
7565:
7562:
7560:
7556:
7553:
7551:
7548:
7545:
7542:
7540:
7536:
7533:
7531:
7528:
7526:
7523:
7521:
7518:
7516:
7513:
7510:
7507:
7505:
7502:
7500:
7497:
7495:
7491:
7488:
7485:
7482:
7480:
7476:
7473:
7471:
7468:
7466:
7463:
7462:
7460:
7458:
7454:
7447:
7444:
7442:
7439:
7437:
7434:
7432:
7429:
7427:
7424:
7422:
7419:
7417:
7414:
7412:
7409:
7407:
7404:
7402:
7399:
7397:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7349:
7347:
7343:
7340:
7339:
7337:
7335:
7331:
7323:
7320:
7316:
7313:
7311:
7308:
7306:
7303:
7302:
7301:
7298:
7297:
7296:
7293:
7289:
7286:
7284:
7281:
7279:
7276:
7274:
7271:
7269:
7266:
7264:
7261:
7259:
7256:
7255:
7254:
7251:
7247:
7244:
7240:
7237:
7235:
7232:
7230:
7227:
7226:
7225:
7222:
7221:
7220:
7217:
7211:
7208:
7206:
7203:
7201:
7198:
7197:
7196:
7193:
7192:
7191:
7188:
7182:
7179:
7177:
7174:
7172:
7169:
7168:
7167:
7164:
7163:
7162:
7159:
7158:
7156:
7154:
7150:
7146:
7141:
7137:
7132:
7128:
7109:
7106:
7104:
7101:
7099:
7095:
7092:
7089:
7086:
7084:
7081:
7079:
7076:
7074:
7070:
7067:
7064:
7061:
7059:
7056:
7054:
7051:
7049:
7046:
7044:
7041:
7039:
7036:
7034:
7031:
7029:
7025:
7022:
7020:
7017:
7015:
7012:
7011:
7009:
7007:
7003:
6996:
6993:
6991:
6988:
6986:
6983:
6981:
6978:
6976:
6973:
6971:
6968:
6966:
6963:
6961:
6958:
6956:
6953:
6951:
6948:
6946:
6943:
6941:
6938:
6936:
6933:
6931:
6928:
6926:
6923:
6921:
6918:
6916:
6913:
6911:
6908:
6906:
6903:
6901:
6898:
6896:
6893:
6891:
6888:
6886:
6883:
6881:
6878:
6876:
6873:
6871:
6868:
6866:
6863:
6861:
6858:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6826:
6823:
6821:
6818:
6816:
6813:
6811:
6808:
6806:
6803:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6661:
6658:
6656:
6653:
6651:
6648:
6646:
6643:
6641:
6638:
6636:
6632:
6629:
6628:
6626:
6624:
6620:
6613:
6610:
6606:
6603:
6601:
6598:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6482:
6481:
6478:
6477:
6475:
6472:
6468:
6465:
6463:Miscellaneous
6461:
6450:
6447:
6445:
6442:
6440:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6415:
6412:
6410:
6407:
6405:
6401:
6398:
6395:
6392:
6390:
6387:
6385:
6382:
6380:
6377:
6375:
6371:
6368:
6365:
6362:
6360:
6357:
6355:
6352:
6350:
6346:
6343:
6341:
6338:
6335:
6332:
6330:
6326:
6323:
6321:
6318:
6315:
6312:
6310:
6306:
6303:
6300:
6296:
6292:
6289:
6287:
6284:
6282:
6279:
6277:
6273:
6270:
6268:
6265:
6262:
6259:
6257:
6253:
6250:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6223:
6220:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6174:
6172:
6168:
6165:
6163:
6160:
6158:
6155:
6153:
6150:
6147:
6144:
6142:
6138:
6135:
6132:
6129:
6127:
6124:
6122:
6118:
6115:
6113:
6110:
6107:
6104:
6102:
6099:
6097:
6093:
6090:
6086:
6083:
6081:
6078:
6077:
6076:
6073:
6070:
6067:
6065:
6061:
6058:
6056:
6053:
6048:
6045:
6043:
6039:
6036:
6033:
6030:
6028:
6025:
6023:
6020:
6019:
6018:
6015:
6013:
6010:
6007:
6004:
6002:
5998:
5995:
5992:
5989:
5987:
5983:
5981:
5977:
5976:Anaphylatoxin
5974:
5973:
5971:
5967:
5960:
5957:
5955:
5951:
5948:
5945:
5942:
5940:
5936:
5933:
5931:
5927:
5924:
5921:
5918:
5916:
5913:
5911:
5908:
5906:
5902:
5899:
5897:
5894:
5891:
5888:
5886:
5882:
5879:
5876:
5873:
5871:
5867:
5864:
5863:
5861:
5859:
5855:
5852:
5848:
5838:
5835:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5808:
5805:
5803:
5800:
5798:
5795:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5753:
5750:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5718:
5715:
5711:
5708:
5706:
5703:
5701:
5698:
5697:
5696:
5693:
5690:
5687:
5685:
5682:
5680:
5677:
5675:
5671:
5668:
5666:
5663:
5661:
5658:
5655:
5652:
5650:
5647:
5645:
5641:
5637:
5634:
5632:
5628:
5625:
5623:
5620:
5619:
5617:
5613:
5607:
5604:
5602:
5599:
5595:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5572:
5568:
5565:
5563:
5559:
5556:
5555:
5554:
5553:Prostaglandin
5551:
5549:
5546:
5544:
5541:
5537:
5534:
5532:
5529:
5528:
5527:
5524:
5521:
5518:
5516:
5512:
5509:
5508:
5506:
5504:
5500:
5497:
5491:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5451:
5448:
5445:
5442:
5440:
5437:
5435:
5431:
5428:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5405:
5404:
5401:
5399:
5396:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5368:
5367:
5364:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5337:
5336:Acetylcholine
5334:
5333:
5331:
5327:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5301:
5298:
5295:
5292:
5290:
5287:
5285:
5281:
5278:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5251:
5248:
5246:
5241:
5240:
5238:
5236:
5232:
5225:
5222:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5166:
5163:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5141:
5138:
5137:
5135:
5133:
5129:
5123:
5120:
5118:
5115:
5113:
5110:
5107:
5104:
5102:
5099:
5097:
5093:
5090:
5087:
5084:
5082:
5079:
5077:
5073:
5070:
5069:
5067:
5065:
5061:
5058:
5056:
5052:
5048:
5043:
5039:
5034:
5030:
5026:
5022:
5015:
5010:
5008:
5003:
5001:
4996:
4995:
4992:
4988:
4987:
4985:
4984:public domain
4981:
4972:
4968:
4965:
4961:
4957:
4953:
4952:
4939:
4935:
4930:
4925:
4921:
4917:
4913:
4909:
4905:
4898:
4890:
4886:
4882:
4878:
4874:
4870:
4866:
4862:
4855:
4847:
4843:
4838:
4833:
4829:
4825:
4821:
4817:
4813:
4806:
4798:
4794:
4789:
4784:
4780:
4776:
4772:
4768:
4767:Endocrinology
4764:
4757:
4749:
4745:
4740:
4735:
4731:
4727:
4723:
4719:
4715:
4708:
4700:
4696:
4691:
4686:
4682:
4678:
4677:Endocrinology
4674:
4667:
4659:
4655:
4650:
4645:
4641:
4637:
4633:
4629:
4625:
4618:
4610:
4606:
4601:
4596:
4592:
4588:
4584:
4580:
4576:
4569:
4561:
4555:
4551:
4550:
4542:
4540:
4531:
4525:
4521:
4520:
4512:
4510:
4501:
4497:
4492:
4487:
4483:
4479:
4475:
4471:
4467:
4460:
4452:
4448:
4443:
4438:
4434:
4430:
4426:
4422:
4418:
4411:
4409:
4407:
4398:
4394:
4389:
4384:
4380:
4376:
4372:
4368:
4364:
4357:
4349:
4345:
4341:
4337:
4333:
4329:
4325:
4321:
4314:
4306:
4302:
4297:
4292:
4288:
4284:
4280:
4276:
4272:
4265:
4257:
4253:
4249:
4245:
4241:
4237:
4230:
4222:
4218:
4213:
4208:
4204:
4200:
4196:
4192:
4188:
4181:
4174:
4173:NO-dependent.
4169:
4165:
4160:
4155:
4151:
4147:
4143:
4139:
4135:
4128:
4120:
4116:
4111:
4106:
4101:
4096:
4092:
4088:
4084:
4077:
4075:
4066:
4062:
4058:
4054:
4050:
4046:
4039:
4031:
4027:
4023:
4019:
4015:
4011:
4010:Life Sciences
4004:
3996:
3992:
3988:
3984:
3980:
3976:
3969:
3961:
3957:
3952:
3947:
3942:
3937:
3933:
3929:
3925:
3918:
3910:
3906:
3901:
3896:
3892:
3888:
3884:
3880:
3876:
3869:
3867:
3865:
3856:
3852:
3848:
3844:
3837:
3829:
3825:
3821:
3817:
3813:
3809:
3805:
3798:
3790:
3786:
3782:
3778:
3774:
3770:
3766:
3759:
3751:
3747:
3742:
3737:
3733:
3729:
3725:
3721:
3717:
3710:
3702:
3698:
3694:
3690:
3686:
3682:
3675:
3667:
3663:
3659:
3655:
3651:
3647:
3640:
3632:
3628:
3623:
3618:
3614:
3610:
3607:(10): e1428.
3606:
3602:
3598:
3591:
3583:
3579:
3574:
3569:
3564:
3559:
3555:
3551:
3547:
3540:
3532:
3528:
3524:
3520:
3516:
3512:
3504:
3496:
3492:
3487:
3482:
3478:
3474:
3470:
3466:
3462:
3455:
3447:
3443:
3439:
3435:
3431:
3427:
3419:
3411:
3407:
3402:
3397:
3393:
3389:
3385:
3381:
3377:
3370:
3362:
3358:
3353:
3348:
3343:
3338:
3334:
3330:
3326:
3319:
3310:
3305:
3301:
3297:
3290:
3282:
3278:
3274:
3270:
3266:
3262:
3255:
3247:
3243:
3238:
3233:
3228:
3223:
3219:
3215:
3211:
3204:
3196:
3192:
3188:
3184:
3180:
3176:
3169:
3161:
3157:
3152:
3147:
3142:
3137:
3133:
3129:
3126:(4): e34672.
3125:
3121:
3117:
3110:
3102:
3098:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3061:
3053:
3049:
3045:
3041:
3037:
3033:
3029:
3025:
3017:
3009:
3005:
3000:
2995:
2991:
2987:
2983:
2979:
2975:
2968:
2960:
2954:
2946:
2942:
2937:
2932:
2928:
2924:
2920:
2916:
2912:
2905:
2897:
2893:
2888:
2883:
2879:
2875:
2871:
2867:
2863:
2856:
2848:
2844:
2840:
2836:
2832:
2828:
2824:
2820:
2813:
2805:
2801:
2797:
2793:
2789:
2785:
2781:
2777:
2770:
2762:
2758:
2753:
2748:
2744:
2740:
2736:
2729:
2722:
2717:
2713:
2709:
2705:
2701:
2697:
2690:
2682:
2678:
2674:
2670:
2666:
2662:
2658:
2654:
2646:
2638:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2603:
2595:
2591:
2586:
2581:
2577:
2573:
2569:
2565:
2558:
2550:
2546:
2542:
2538:
2533:
2528:
2524:
2520:
2516:
2509:
2501:
2497:
2493:
2489:
2485:
2481:
2477:
2473:
2466:
2458:
2454:
2450:
2446:
2441:
2436:
2432:
2428:
2424:
2420:
2416:
2409:
2407:
2405:
2396:
2392:
2387:
2382:
2378:
2374:
2370:
2366:
2362:
2355:
2353:
2344:
2340:
2336:
2332:
2327:
2322:
2318:
2314:
2310:
2303:
2295:
2291:
2286:
2281:
2277:
2273:
2269:
2265:
2261:
2254:
2252:
2250:
2248:
2239:
2235:
2231:
2227:
2223:
2219:
2212:
2204:
2200:
2194:
2186:
2182:
2176:
2169:
2165:
2160:
2158:
2156:
2148:
2144:
2139:
2137:
2135:
2130:
2120:
2117:
2115:
2112:
2110:
2103:
2101:
2098:
2097:
2091:
2082:
2080:
2076:
2072:
2068:
2065:and impaired
2064:
2063:hyperglycemia
2060:
2059:knockout mice
2050:
2048:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1986:
1984:
1980:
1979:17β-estradiol
1976:
1972:
1962:
1960:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1921:
1917:
1916:knockout mice
1913:
1910:
1906:
1891:
1887:
1883:
1874:
1872:
1868:
1864:
1860:
1856:
1851:
1847:
1843:
1831:
1828:
1826:
1825:17α-Estradiol
1823:
1822:
1814:
1811:
1809:
1806:
1805:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1773:
1765:
1762:
1760:
1757:
1755:
1752:
1750:
1747:
1745:
1742:
1740:
1737:
1734:
1731:
1729:
1726:
1724:
1721:
1719:
1716:
1714:
1711:
1709:
1706:
1704:
1701:
1699:
1696:
1694:
1691:
1689:
1686:
1684:
1681:
1679:
1676:
1674:
1671:
1669:(ICI-182780))
1668:
1665:
1663:
1660:
1658:
1655:
1653:
1650:
1647:
1644:
1641:
1637:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1594:
1588:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1531:
1527:
1517:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1465:
1463:
1459:
1456:
1452:
1448:
1444:
1440:
1436:
1424:
1419:
1415:
1411:
1408:
1404:
1397:
1395:
1392:
1388:
1384:
1380:
1377:
1373:
1369:
1362:
1360:
1354:
1350:
1347:
1341:
1339:
1335:
1331:
1325:
1321:
1318:
1314:
1307:
1305:
1299:
1295:
1292:
1286:
1284:
1280:
1276:
1272:
1266:
1262:
1259:
1257:RefSeq (mRNA)
1255:
1248:
1247:
1242:
1238:
1235:
1229:
1228:
1223:
1219:
1216:
1214:
1210:
1203:
1202:
1197:
1193:
1190:
1184:
1183:
1178:
1174:
1171:
1169:
1165:
1158:
1157:
1152:
1148:
1145:
1139:
1138:
1133:
1129:
1126:
1124:
1120:
1117:
1114:
1112:
1109:
1105:
1102:
1098:
1094:
1087:
1083:
1078:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
783:
781:
778:
777:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
745:cell junction
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
720:axon terminus
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
625:mitochondrion
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
545:
542:
541:
539:
536:
535:
532:
531:Gene ontology
528:
524:
512:
507:
503:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
427:otolith organ
426:
422:
421:
418:
414:
409:
406:
396:
392:
389:apex of heart
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
10255:
9946:
9936:
9860:Mepitiostane
9808:Epitiostanol
9677:Ormeloxifene
9602:Lasofoxifene
9512:Camizestrant
9507:Broparestrol
9497:Bazedoxifene
9419:rotundifuran
9368:alkylphenols
9318:β-zearalenol
9314:α-zearalenol
9300:stigmasterol
9292:β-sitosterol
9288:Phytosterols
9256:triclocarban
9252:methoxychlor
9205:
9187:Lavender oil
9181:tectorigenin
9113:formononetin
8987:
8962:
8833:
8825:
8625:
8609:Quinestradol
8599:Promestriene
8574:Noretynodrel
8438:Estromustine
8391:Estramustine
8326:
8233:testosterone
7970:
7652:
7619:
7592:Metabotropic
7456:
7341:
7294:
7252:
7218:
7189:
7160:
7005:
6630:
6479:
6430:Urotensin-II
6370:Somatostatin
6325:Prokineticin
6222:Melanocortin
5925:
5858:Neuropeptide
5797:Oxoglutarate
5664:
5639:
5601:Prostacyclin
5570:
5557:
5510:
5398:GHB receptor
5299:
5242:
4977:
4976:
4967:GPER+protein
4959:
4911:
4907:
4897:
4864:
4860:
4854:
4819:
4815:
4805:
4770:
4766:
4756:
4721:
4717:
4707:
4680:
4676:
4666:
4631:
4627:
4617:
4582:
4578:
4568:
4548:
4518:
4473:
4469:
4459:
4424:
4421:Neuroscience
4420:
4370:
4366:
4356:
4323:
4319:
4313:
4278:
4274:
4264:
4239:
4235:
4229:
4194:
4190:
4180:
4171:
4141:
4138:Hypertension
4137:
4127:
4090:
4086:
4051:(1): 31–36.
4048:
4044:
4038:
4013:
4009:
4003:
3978:
3974:
3968:
3931:
3927:
3917:
3882:
3878:
3846:
3836:
3811:
3807:
3797:
3772:
3768:
3758:
3723:
3719:
3709:
3684:
3680:
3674:
3649:
3645:
3639:
3604:
3600:
3590:
3553:
3549:
3539:
3514:
3510:
3503:
3468:
3464:
3454:
3429:
3425:
3418:
3383:
3379:
3369:
3332:
3328:
3318:
3299:
3289:
3264:
3260:
3254:
3217:
3213:
3203:
3178:
3174:
3168:
3123:
3119:
3109:
3074:
3070:
3060:
3030:(1): 61–71.
3027:
3023:
3016:
2981:
2977:
2967:
2953:
2918:
2914:
2904:
2869:
2865:
2855:
2822:
2818:
2812:
2779:
2775:
2769:
2742:
2738:
2728:
2719:
2699:
2695:
2689:
2656:
2652:
2645:
2612:
2608:
2602:
2567:
2557:
2522:
2518:
2508:
2475:
2471:
2465:
2422:
2418:
2368:
2364:
2316:
2312:
2302:
2267:
2263:
2221:
2217:
2211:
2202:
2193:
2184:
2175:
2088:
2057:Female GPER
2056:
2019:hypothalamus
1992:
1975:vasodilation
1968:
1902:
1888:
1884:
1880:
1855:hypothalamus
1839:
1713:Nicotinamide
1568:
1565:nicotinamide
1549:testosterone
1545:progesterone
1523:
1482:estrogenenic
1471:
1454:
1446:
1442:
1438:
1434:
1433:
1356:
1334:NP_001091671
1330:NP_001035055
1327:
1301:
1279:NM_001098201
1275:NM_001039966
1271:NM_001031682
1268:
1244:
1225:
1199:
1180:
1154:
1135:
1115:
1110:
635:cytoskeleton
373:frontal pole
335:
328:
294:139,413,555
281:139,408,906
55:External IDs
18:
10205:Zearalenone
10157:Antagonists
10133:Resveratrol
10098:Nonylphenol
10093:Niacinamide
10009:Bisphenol A
9999:Aldosterone
9828:Glyceollins
9776:Antagonists
9767:Zuclomifene
9762:Zindoxifene
9672:NNC 45-1506
9667:NNC 45-0781
9662:NNC 45-0320
9657:NNC 45-0095
9652:Nitromifene
9632:Miproxifene
9582:Fispemifene
9557:Enclomifene
9552:Droloxifene
9532:CN-55945-27
9477:Afimoxifene
9467:Acefluranol
9358:rhaponticin
9354:resveratrol
9350:Stilbenoids
9322:zearalenone
9310:zearalanone
9296:campesterol
9228:alternariol
9161:pinocembrin
9105:epicatechin
9077:biochanin A
9017:Chalconoids
8911:Terfluranol
8886:Quadrosilan
8758:Elacestrant
8659:Allenestrol
8534:Lynestrenol
8458:Estropipate
8428:Estrofurate
8279:Clomestrone
8259:Atrimustine
8209:Abiraterone
8163:alfatradiol
7300:Latrophilin
6435:Vasopressin
6420:Thyrotropin
5997:Angiotensin
5950:Neurotensin
5627:Cannabinoid
5606:Thromboxane
3471:(8): e747.
2043:fulvestrant
1971:endothelium
1813:Zearalenone
1770:Antagonists
1749:Resveratrol
1718:Nonylphenol
1667:Fulvestrant
1622:Bisphenol A
1612:Aldosterone
1607:Afimoxifene
1557:aldosterone
1486:metabolites
273:5|5 G2
33:Identifiers
10262:Categories
10148:Tectoridin
10128:Raloxifene
10103:Oleuropein
9950:Trilostane
9895:Prochloraz
9855:MDL-101906
9850:ICI-164384
9737:Trioxifene
9732:Toremifene
9702:Raloxifene
9687:Panomifene
9682:Ospemifene
9647:Nafoxidine
9537:Cyclofenil
9492:Arzoxifene
9472:Acolbifene
9404:phthalates
9372:bisphenols
9344:miroestrol
9248:methiocarb
9236:endosulfan
9224:Pesticides
9196:enterodiol
9177:tectoridin
9157:penduletin
9153:naringenin
9137:kaempferol
9053:Flavonoids
9047:psoralidin
9043:coumestrol
9039:Coumestans
9003:dianethole
8956:WAY-214156
8946:WAY-200070
8941:WAY-169916
8936:WAY-166818
8906:SKF-82,958
8871:Phenestrol
8851:Methestrol
8836:-Hexestrol
8828:-Butestrol
8709:Dienestrol
8689:Carbestrol
8674:Bifluranol
8669:Benzestrol
8614:Quinestrol
8564:Nilestriol
8406:Estrazinol
8339:Epimestrol
8329:-Estradiol
8311:Cyclotriol
8249:nandrolone
8224:Almestrone
8059:7-Oxo-DHEA
7971:Steroidal:
7943:modulators
7890:Smoothened
7883:Smoothened
7806:Smoothened
7465:Calcitonin
6400:Tachykinin
6297:, but not
6291:Nociceptin
6157:Kisspeptin
6075:Endothelin
6038:Bradykinin
5926:Neuromedin
5503:Eicosanoid
5132:Purinergic
5064:Adrenergic
4867:: 100786.
4634:: 98–103.
3926:. review.
3720:Oncotarget
2170:, May 2017
2149:, May 2017
2125:References
2075:osteoblast
2011:expression
2007:anxiolytic
2003:anxiogenic
1939:germ cells
1819:Non-ligand
1764:Tectoridin
1744:Raloxifene
1723:Oleuropein
1535:, such as
1530:endogenous
811:cell cycle
339:(ortholog)
193:1,093,815
180:1,082,208
76:HomoloGene
10143:Tamoxifen
10123:Quercetin
10063:Genistein
10043:Estradiol
10027:o',p'-DDE
9930:ZK-191703
9925:ZK-164015
9885:Phenytoin
9783:(R,R)-THC
9722:Tamoxifen
9697:Promensil
9622:LY-117018
9597:Idoxifene
9592:ICI-55548
9577:Femarelle
9562:Endoxifen
9522:Clomifene
9278:diosgenin
9274:digitalis
9270:digitoxin
9260:triclosan
9240:fenarimol
9173:quercetin
9149:myricetin
9145:mirificin
9133:glycitein
9125:genistein
9121:glabridin
9081:calycosin
9069:baicalein
9025:phloretin
8981:ZK-283197
8841:Mestilbol
8803:Hexestrol
8778:Fenestrel
8753:Efavirenz
8684:Butestrol
8639:2,8-DHHHC
8634:(S,S)-THC
8629:(R,R)-THC
8584:Pentolame
8579:Orestrate
8554:Moxestrol
8544:Mestranol
8509:Etynodiol
8369:Estradiol
8344:Equilenin
8306:Cyclodiol
8264:Bolandiol
7800:Class F:
7599:pheromone
7595:glutamate
7019:Olfactory
6055:Chemokine
5837:Succinate
5622:Bile acid
5430:Melatonin
5403:Histamine
5243:(all but
5235:Serotonin
5140:Adenosine
5042:Rhodopsin
4889:202043731
4348:205595404
4242:: 53–60.
3828:0923-7534
3789:0732-183X
3335:(1): 51.
3220:(1): 87.
2745:: 37–45.
2343:196618575
2039:tamoxifen
1999:estradiol
1943:fertility
1925:, unlike
1923:phenotype
1842:rhodopsin
1759:Tamoxifen
1739:Quercetin
1678:Genistein
1657:Estradiol
1640:o',p'-DDE
1533:estrogens
1500:class of
1468:Discovery
1462:estradiol
1359:NP_084047
1338:NP_001496
1304:NM_029771
1283:NM_001505
1101:Orthologs
595:cytoplasm
84:GeneCards
10221:See also
10023:p,p'-DDT
10014:Daidzein
10004:Atrazine
9977:Agonists
9905:RU-58668
9900:RU-39411
9747:U-11555A
9742:TZE-5323
9487:Anordrin
9482:Anordiol
9415:agnuside
9392:parabens
9232:dieldrin
9204:nyasol (
9169:puerarin
9165:prunetin
9129:genistin
9117:glabrene
9089:daidzein
9085:catechin
9073:baicalin
9065:apigenin
8995:anethole
8783:FERb 033
8619:Tibolone
8604:RU-16117
8589:Prodiame
8524:Hippulin
8519:Hexolame
8364:Estetrol
8274:Butolame
7964:Agonists
7824:Frizzled
7817:Frizzled
7802:Frizzled
7644:, type 2
7550:Secretin
7490:Glucagon
7195:Cadherin
7153:Adhesion
7140:Secretin
6473:, bitter
6320:Oxytocin
6017:Bombesin
5665:Estrogen
5366:Dopamine
4938:29659348
4881:31513775
4846:31996464
4797:23970785
4748:20734455
4699:18845638
4658:28063803
4609:25245158
4500:22143579
4451:19095043
4397:19430488
4340:20700047
4305:27803283
4256:23466742
4221:22153880
4168:22203741
4119:24474947
4065:22440937
4030:21703280
3995:22139333
3960:24834064
3909:24718936
3814:: S663.
3750:29899833
3701:24553912
3666:24515910
3631:25275589
3582:24834064
3531:32376419
3495:23907461
3446:23921077
3426:Steroids
3410:25287069
3361:23849542
3281:28467693
3246:28476123
3195:27082459
3160:22496838
3120:PLOS ONE
3101:19501895
3052:10593826
3044:24715381
3008:19420011
2945:21782022
2896:19430488
2839:16520733
2804:24889239
2796:20568229
2761:26921679
2739:Steroids
2716:24662263
2681:28896943
2673:24239983
2637:28968323
2629:22285849
2609:Steroids
2594:17222505
2549:27712910
2541:16270355
2500:33801811
2492:16125968
2457:15789136
2449:15705806
2395:25351351
2335:21888507
2319:: 1–11.
2294:26023144
2218:Genomics
2166:–
2145:–
2094:See also
2061:display
2047:lordosis
2025:and the
2015:oxytocin
1836:Function
1636:p,p'-DDT
1627:Daidzein
1617:Atrazine
1591:Agonists
1569:in vitro
1553:cortisol
1526:affinity
1488:such as
1449:), is a
1407:Wikidata
1080:Sources:
750:dendrite
610:membrane
600:endosome
393:testicle
10193:Unknown
10169:Estriol
10073:GPER-L2
10068:GPER-L1
9752:U-11634
9627:Menerba
9617:LN-2299
9612:LN-1643
9587:GW-7604
9542:D-15413
9374:(e.g.,
9366:(e.g.,
9352:(e.g.,
9336:Steroid
9308:(e.g.,
9290:(e.g.,
9268:(e.g.,
9226:(e.g.,
9218:cadmium
9216:(e.g.,
9194:(e.g.,
9192:Lignans
9093:daidzin
9057:7,8-DHF
9055:(incl.
9041:(e.g.,
9019:(e.g.,
8901:SERBA-2
8896:SC-4289
8891:SC-3296
8798:GTx-758
8694:D-15414
8644:β-LGND1
8594:Prolame
8443:Estrone
8411:Estriol
8349:Equilin
8231:(e.g.,
8144:16α-LE2
7613:, sweet
7588:Class C
7520:PACAPR1
7136:Class B
6345:Relaxin
6267:Motilin
6152:Ghrelin
6117:Galanin
5850:Peptide
5038:Class A
4929:5988531
4837:7083206
4788:3800768
4739:3179349
4649:5359066
4600:4254307
4491:3350630
4442:2747636
4388:2864230
4296:5124501
4212:3240864
4159:3266468
4110:3893621
3951:4018520
3900:4091989
3741:5995224
3622:4649509
3573:4018520
3486:3763437
3401:4233119
3352:3723961
3237:5418684
3151:3319601
3128:Bibcode
3092:2921775
2999:2710976
2936:3220788
2887:2864230
2847:2364534
2585:1847610
2427:Bibcode
2419:Science
2386:4210253
2285:4485017
2238:9479505
2168:Ensembl
2147:Ensembl
1920:mammary
1830:Estrone
1802:Unknown
1781:Estriol
1703:LNS8801
1688:GPER-L2
1683:GPER-L1
1541:estriol
1537:estrone
1520:Ligands
1494:estriol
1490:estrone
1451:protein
1213:UniProt
1168:Ensembl
1107:Species
1086:QuickGO
640:nucleus
615:synapse
439:condyle
431:utricle
314:pattern
72:1924104
40:Aliases
10088:Niacin
10083:Kepone
9940:ERX-11
9910:SS1020
9818:ERB-88
9813:ERA-90
9717:SS1010
9642:MRL-37
9007:dianol
8976:ERB-79
8971:ERA-45
8966:ERB-26
8699:DCW234
8654:AC-186
8321:DHEA-S
8253:esters
8237:esters
8089:8β-VE2
7804:&
7733:GPRC6A
7470:CALCRL
7334:Orphan
6623:Orphan
6614:type 1
6305:Orexin
6293:&
6272:Opioid
6012:Apelin
4973:(MeSH)
4936:
4926:
4887:
4879:
4844:
4834:
4795:
4785:
4746:
4736:
4697:
4656:
4646:
4607:
4597:
4556:
4526:
4498:
4488:
4449:
4439:
4395:
4385:
4346:
4338:
4303:
4293:
4254:
4219:
4209:
4166:
4156:
4117:
4107:
4063:
4028:
3993:
3958:
3948:
3934:: 66.
3907:
3897:
3826:
3787:
3748:
3738:
3699:
3664:
3629:
3619:
3580:
3570:
3556:: 66.
3529:
3493:
3483:
3444:
3408:
3398:
3359:
3349:
3279:
3244:
3234:
3193:
3158:
3148:
3099:
3089:
3050:
3042:
3006:
2996:
2943:
2933:
2894:
2884:
2845:
2837:
2802:
2794:
2759:
2714:
2679:
2671:
2635:
2627:
2592:
2582:
2547:
2539:
2498:
2490:
2455:
2447:
2393:
2383:
2341:
2333:
2292:
2282:
2236:
1957:(HPG)
1909:breast
1708:Niacin
1698:Kepone
1561:Niacin
1551:, and
1393:search
1391:PubMed
1246:Q8BMP4
1227:Q99527
1123:Entrez
485:BioGPS
369:fundus
172:7p22.3
64:601805
10164:CCL18
10038:Equol
9920:ZB716
9890:PHTPP
9757:Y-134
9434:SERMs
9429:Mixed
9109:equol
8991:Anise
8820:M2613
7653:Other
7620:TAS1R
7611:Taste
7509:GLP2R
7504:GLP1R
7457:Other
7322:ELTD1
7295:ADGRL
7253:ADGRG
7219:ADGRE
7190:ADGRC
7161:ADGRB
7142:-like
7024:Opsin
7006:Other
6480:TAS2R
6471:Taste
6299:Sigma
6281:Kappa
6276:Delta
5984:C5a (
5969:Other
5615:Other
5543:FPRL1
5511:CysLT
5329:Other
5280:5-HT2
5250:5-HT1
5245:5-HT3
5044:-like
4885:S2CID
4344:S2CID
4093:: 1.
3300:eLife
3048:S2CID
2843:S2CID
2800:S2CID
2677:S2CID
2633:S2CID
2545:S2CID
2496:S2CID
2453:S2CID
2339:S2CID
1871:ovary
1776:CCL18
1735:(PPT)
1652:Equol
1648:(DPN)
1573:CCL18
1447:GPR30
1156:76854
1116:Mouse
1111:Human
1082:Amigo
443:fossa
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:GPER1
80:15855
47:GPER1
24:GPER1
10184:MIBE
10179:G-36
10174:G-15
10108:PCBs
9965:GPER
9875:MIBE
9408:PCBs
9400:PHBA
9396:PBBs
9244:HPTE
9101:EGCG
8999:anol
8834:meso
8826:meso
8316:DHEA
8251:and
8235:and
7758:RAIG
7666:GABA
7499:GIPR
7246:CD97
7094:SREB
6895:137B
6870:109B
6865:109A
6295:Zeta
6252:MCHR
6032:NMBR
6027:GRPR
6022:BRS3
5660:EBI2
5526:LTB4
5450:TAAR
5300:5-HT
4934:PMID
4877:PMID
4842:PMID
4793:PMID
4744:PMID
4695:PMID
4654:PMID
4605:PMID
4554:ISBN
4524:ISBN
4496:PMID
4447:PMID
4393:PMID
4336:PMID
4301:PMID
4252:PMID
4217:PMID
4164:PMID
4115:PMID
4061:PMID
4026:PMID
3991:PMID
3956:PMID
3905:PMID
3824:ISSN
3785:ISSN
3746:PMID
3697:PMID
3662:PMID
3627:PMID
3578:PMID
3527:PMID
3491:PMID
3442:PMID
3406:PMID
3357:PMID
3277:PMID
3242:PMID
3191:PMID
3156:PMID
3097:PMID
3040:PMID
3004:PMID
2941:PMID
2892:PMID
2835:PMID
2792:PMID
2757:PMID
2712:PMID
2669:PMID
2625:PMID
2590:PMID
2537:PMID
2488:PMID
2445:PMID
2391:PMID
2331:PMID
2290:PMID
2234:PMID
2114:ER-X
2109:-mER
2041:and
1959:axis
1796:MIBE
1583:and
1563:and
1458:gene
1455:GPER
1439:GPER
1137:2852
710:axon
459:hand
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
60:OMIM
10138:STX
10058:G-1
10019:DDT
9840:III
9388:DDT
9386:),
9384:BPS
9380:BPF
9376:BPA
9276:),
9206:cis
9097:ECG
8327:ent
7752:179
7747:158
7742:156
7738:GPR
7525:GPR
7446:157
7441:155
7436:144
7431:143
7426:133
7421:128
7416:126
7411:125
7406:124
7401:123
7396:116
7391:115
7386:114
7381:113
7376:112
7371:111
7366:110
7342:GPR
7224:EMR
7063:RRH
7058:RGR
7053:1SW
7048:1MW
7043:1LW
6995:183
6990:182
6985:177
6980:176
6975:174
6970:173
6965:171
6960:162
6955:161
6950:160
6945:153
6940:152
6935:151
6930:150
6925:149
6920:148
6915:146
6910:142
6905:141
6900:139
6890:135
6885:132
6880:120
6875:119
6860:103
6855:101
6631:GPR
6167:MAS
6112:FSH
5980:C3a
5866:B/W
5802:PAF
5654:119
5640:GPR
5636:CB2
5631:CB1
5592:),
5569:),
5548:OXE
5165:P2Y
5154:A2B
5149:A2A
4924:PMC
4916:doi
4869:doi
4832:PMC
4824:doi
4783:PMC
4775:doi
4771:154
4734:PMC
4726:doi
4685:doi
4681:150
4644:PMC
4636:doi
4595:PMC
4587:doi
4486:PMC
4478:doi
4474:221
4437:PMC
4429:doi
4425:158
4383:PMC
4375:doi
4328:doi
4291:PMC
4283:doi
4244:doi
4207:PMC
4199:doi
4154:PMC
4146:doi
4105:PMC
4095:doi
4053:doi
4018:doi
3983:doi
3946:PMC
3936:doi
3895:PMC
3887:doi
3851:doi
3816:doi
3777:doi
3736:PMC
3728:doi
3689:doi
3685:140
3654:doi
3650:140
3617:PMC
3609:doi
3568:PMC
3558:doi
3519:doi
3481:PMC
3473:doi
3434:doi
3396:PMC
3388:doi
3347:PMC
3337:doi
3304:doi
3269:doi
3232:PMC
3222:doi
3183:doi
3146:PMC
3136:doi
3087:PMC
3079:doi
3075:114
3032:doi
3028:145
2994:PMC
2986:doi
2982:202
2931:PMC
2923:doi
2919:127
2882:PMC
2874:doi
2827:doi
2784:doi
2780:225
2747:doi
2743:111
2704:doi
2661:doi
2657:382
2617:doi
2580:PMC
2572:doi
2527:doi
2523:207
2480:doi
2435:doi
2423:307
2381:PMC
2373:doi
2321:doi
2280:PMC
2272:doi
2226:doi
2119:ERx
1931:ERβ
1927:ERα
1791:G36
1786:G15
1754:STX
1673:G-1
1632:DDT
1585:G36
1581:G15
1577:G-1
1539:or
1492:or
290:End
189:End
92:OMA
68:MGI
10264::
10025:,
9844:IV
9842:,
9838:,
9836:II
9834:,
9417:,
9406:,
9402:,
9398:,
9394:,
9390:,
9382:,
9378:,
9370:,
9356:,
9342:,
9328:,
9324:,
9320:,
9316:,
9312:,
9298:,
9294:,
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