262:
239:
161:
136:
268:
167:
6693:
3679:
1711:
and a rs324420 C385A mutation. The result is extreme disruption of FAAH function leading to elevated anandamide levels. She was immune to anxiety, unable to experience fear, and insensitive to pain. The frequent burns and cuts suffered due to her hypoalgesia healed quicker than average with little or
1282:) has been linked to severe adverse events affecting 5 patients in a drug trial in Rennes, France, and at least one death, in January 2016. Many other pharmaceutical companies have previously taken other FAAH inhibitors into clinical trials without reporting such adverse events.
1667:
The C385A allele was initially provisionally linked to drug abuse and dependence but this was not borne out in subsequent studies. According to later studies, carriers of the A allele are more likely to try cannabis, but less likely to become dependent.
3728:
Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF (January 1999). "Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition".
2717:
Berardi A, Schelling G, Campolongo P (September 2016). "The endocannabinoid system and Post
Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings".
2482:
Sałaga M, Sobczak M, Fichna J (February 2014). "Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract".
275:
174:
3693:
Roughley SD, Browne H, Macias AT, Benwell K, Brooks T, D'Alessandro J, et al. (January 2012). "Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity".
2569:"Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice"
3380:
5244:
3509:
Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, et al. (November 2007). "Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity".
1468:) in clinical trials for neuropathic pain following spinal injury, and spasticity associated with multiple sclerosis. Structure not revealed though Vernalis holds several patents in the area.
3677:, Roughly S, Walls S, Hart T, Parsons R, Brough P, Graham C, Macias A, "Azetidine derivatives as FAAH inhibitors", published 28 May 2013, assigned to Vernalis (R&D) Ltd.
3621:
Hart T, Macias AT, Benwell K, Brooks T, D'Alessandro J, Dokurno P, et al. (August 2009). "Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas".
1478:
Structural and conformational properties that contribute to enzyme inhibition and substrate binding imply an extended bound conformation, and a role for the presence, position, and
6101:
1653:. The A variant may be responsible for lower levels of the FAAH protein seen in high-performing athletes, providing increased physical and mental fitness. However, among elite
2369:
Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA (June 1995). "Chemical characterization of a family of brain lipids that induce sleep".
2014:
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB (November 1996). "Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides".
1735:
also changes the expression of a wide network of genes beyond FAAH itself. For example, although the pain insensitivity is mostly due to loss of FAAH function (via increased
1657:
athletes, the A variant is under-represented regardless of metabolic characteristics of their sport disciplines; this seems to suggest an opposite role for the A variant.
2188:
Patricelli MP, Cravatt BF (October 1999). "Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism".
1438:-based mechanism, and appears in one report as a somewhat selective, though it also inactivates other serine hydrolases (e.g., carboxylesterases) in peripheral tissues.
5848:
5717:
4346:
1431:
2137:
Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF (November 2002). "Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling".
6027:
2412:
Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF (August 2006). "A FAAH-regulated class of N-acyl taurines that activates TRP ion channels".
6094:
5380:
5054:
3384:
722:
97:
5441:
1786:
code 1MT5). Structures of FAAH with drug-like ligands were first reported in 2008, and include non-covalent inhibitor complexes and covalent adducts.
703:
1323:
in clinical trials against social anxiety and depression, trials suspended as a precautionary measure following serious adverse event with BIA 10-2474
1408:
well tolerated in clinical trials but insufficient efficacy against depression, subsequently trialled against cancer pain as an adjunctive treatment.
1723:
using transcriptomic analyses of cell models, some created anew using CRISPR-Cas9, others obtained from the 2019 patient. The study confirms that
6087:
5512:
4099:
1315:
1310:
1305:
5853:
5687:
5375:
5279:
4339:
3381:"Janssen Research & Development, LLC Voluntarily Suspends Dosing in Phase 2 Clinical Trials of Experimental Treatment for Mood Disorders"
1936:
1376:
1300:
1918:
5431:
5269:
5264:
5259:
4777:
1451:
1405:
1285:
1346:
1290:
1838:. The systematic name is "fatty acylamide amidohydrolase". Recorded synonyms include "oleamide hydrolase", "anandamide amidohydrolase".
5808:
5798:
5567:
5436:
1461:
2960:
Petrosino S, Di Marzo V (January 2010). "FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels".
2758:"Identification of N-acylethanolamines in Dictyostelium discoideum and confirmation of their hydrolysis by fatty acid amide hydrolase"
929:
6039:
5911:
5886:
5881:
5828:
5752:
5597:
5592:
5587:
5572:
5532:
5522:
5451:
4869:
4475:
4440:
1411:
1336:
1295:
1261:
922:
5936:
5931:
5843:
5833:
5813:
5777:
5762:
5757:
5732:
5557:
5552:
5421:
5355:
5350:
5345:
5299:
5294:
5289:
4964:
4332:
1446:
1441:
1422:
1390:
1366:
1361:
1356:
5926:
5921:
5916:
5906:
5901:
5896:
5891:
5747:
5742:
1417:
1400:
1395:
1351:
1248:
6365:
6277:
6244:
6172:
4124:
Wang Y, Jones P (2009). "A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening".
1384:(JZP-150; PF-04457845) – "exquisitely selective" for FAAH over other serine hydrolases, but failed in clinical trials against
6330:
6211:
6123:
5969:
5838:
5712:
4141:
3561:
2864:"Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies"
2809:"N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation"
1167:
Studies in cells and animals and genetic studies in humans have shown that inhibiting FAAH may be a useful strategy to treat
1901:
6713:
1979:
Deutsch DG, Chin SA (September 1993). "Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist".
6728:
2987:
Minkkilä A, Saario S, Nevalainen T (2010). "Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors".
2228:"Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase"
1880:
6342:
3185:
2621:"Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction"
5649:
4011:"Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity"
3661:
for "A Safety, Tolerability and
Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury" at
3544:
Fowler CJ (2015). "The
Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review".
1852:
6412:
3862:"Genetic variants associated with physical and mental characteristics of the elite athletes in the Polish population"
1483:
3141:
Lodola A, Castelli R, Mor M, Rivara S (2015). "Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)".
261:
3590:
for "An Eight-week Study of SSR411298 as
Treatment for Major Depressive Disorder in Elderly Patients (FIDELIO)" at
3459:"Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders"
2447:
Cravatt BF, Lichtman AH (October 2004). "The endogenous cannabinoid system and its role in nociceptive behavior".
3766:"Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery"
3057:
Bisogno T, Maccarrone M (May 2013). "Latest advances in the discovery of fatty acid amide hydrolase inhibitors".
1905:
1884:
238:
6305:
6012:
2324:, Cravatt BF (November 2004). "Assignment of endogenous substrates to enzymes by global metabolite profiling".
1627:
767:
6718:
6568:
3406:
Moore SA, Nomikos GG, Dickason-Chesterfield AK, Schober DA, Schaus JM, Ying BP, et al. (December 2005).
1805:
produces a semispecific FAAH inhibitor. By controlling the levels of FAAH activity, they modulate endogenous
1660:
A 2017 study found a strong correlation between national percentage of very happy people (as measured by the
4167:"Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor"
748:
6059:
5239:
4834:
4510:
4420:
1233:
1112:
160:
135:
77:
3603:
2913:"Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders"
2285:
Ueda N, Puffenbarger RA, Yamamoto S, Deutsch DG (November 2000). "The fatty acid amide hydrolase (FAAH)".
5496:
5479:
5157:
4806:
4383:
1602:
1237:
3022:
Khanna IK, Alexander CW (August 2011). "Fatty acid amide hydrolase inhibitors--progress and potential".
1828:. The number applies to all enzymes that have the chemical activity; in humans it covers both the genes
1578:
6683:
6267:
5628:
3947:
Mikaeili H, Habib AM, Yeung CW, Santana-Varela S, Luiz AP, Panteleeva K, et al. (September 2023).
3860:
Peplonska B, Adamczyk JG, Siewierski M, Safranow K, Maruszak A, Sozanski H, et al. (August 2017).
3765:
274:
173:
4303:
3674:
6669:
6656:
6643:
6630:
6617:
6604:
6591:
6553:
5644:
3274:"Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)"
3102:"Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications"
1630:(SNP) called rs324420. The variant allele, C385A, is associated with a higher sensitivity of FAAH to
1532:
267:
166:
4073:
1954:
64:
6563:
6517:
6460:
6114:
6079:
6007:
5284:
4839:
4520:
4307:
3673:
2338:
1847:
1822:
1818:
1801:
1767:
85:
17:
6465:
6184:
5787:
5004:
4595:
4366:
4052:
1857:
1486:
2226:
Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH (July 2001).
905:
884:
858:
837:
5662:
5527:
5049:
4829:
4782:
4415:
2859:
2333:
1214:
1210:
1072:
4224:
Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, et al. (September 2008).
3408:"Identification of a high-affinity binding site involved in the transport of endocannabinoids"
1142:
6486:
6405:
6066:
5314:
4405:
4372:
1133:-acyltaurines in various tissues. Because of their significantly elevated anandamide levels,
1093:
33:
4165:
Han B, Wright R, Kirchhoff AM, Chester JA, Cooper BR, Davisson VJ, Barker E (January 2013).
3901:
Minkov M, Bond MH (2017-04-01). "A Genetic
Component to National Differences in Happiness".
3331:
Keith JM, Jones WM, Tichenor M, Liu J, Seierstad M, Palmer JA, et al. (December 2015).
6558:
6315:
5319:
5249:
5182:
5177:
5152:
5044:
4620:
4355:
4237:
3285:
2378:
2239:
2146:
2078:
2023:
1650:
1590:
1500:
1207:
1195:
1033:
149:
105:
8:
6522:
6295:
6194:
4515:
4505:
4226:"Structure-guided inhibitor design for human FAAH by interspecies active site conversion"
1696:
1661:
1638:
compared to the standard C variant. As a result, carriers of the A variant has increased
4241:
3983:
3948:
3837:
3806:
3463:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
3289:
2382:
2243:
2150:
2082:
2027:
6455:
6320:
5485:
5446:
5309:
5075:
4844:
4358:
4283:
4260:
4225:
4191:
4166:
4035:
4010:
3926:
3662:
3591:
3483:
3458:
3434:
3407:
3357:
3332:
3308:
3273:
3249:
3224:
3193:
3166:
3082:
2937:
2912:
2888:
2863:
2835:
2808:
2784:
2757:
2694:
2669:
2645:
2620:
2593:
2568:
2544:
2519:
2170:
2047:
1751:. The increased wound healing is due to both pathways: loss of FAAH function increases
1639:
1188:
1086:
1079:
1001:
109:
3742:
2298:
637:
632:
627:
611:
606:
601:
596:
591:
586:
581:
565:
560:
555:
550:
545:
6723:
6290:
4265:
4214:
4196:
4147:
4137:
4040:
3988:
3918:
3883:
3842:
3787:
3746:
3710:
3638:
3567:
3557:
3526:
3488:
3439:
3362:
3313:
3254:
3158:
3123:
3074:
3039:
3004:
2969:
2942:
2893:
2840:
2789:
2735:
2699:
2650:
2636:
2598:
2567:
Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, et al. (August 2015).
2549:
2500:
2464:
2429:
2394:
2351:
2302:
2267:
2262:
2227:
2205:
2162:
2127:
2106:
2101:
2066:
2039:
1996:
1992:
1783:
1184:
1168:
57:
4319:
3930:
3272:
Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, et al. (May 2011).
3170:
3086:
2174:
6501:
6496:
6470:
6398:
5617:
5411:
4255:
4245:
4186:
4178:
4129:
4030:
4022:
3978:
3968:
3960:
3910:
3873:
3832:
3822:
3777:
3738:
3702:
3630:
3549:
3518:
3478:
3470:
3429:
3419:
3352:
3348:
3344:
3303:
3293:
3244:
3236:
3198:
3150:
3113:
3066:
3031:
2996:
2932:
2924:
2883:
2875:
2830:
2820:
2779:
2769:
2727:
2689:
2681:
2640:
2632:
2588:
2580:
2539:
2531:
2492:
2456:
2421:
2386:
2343:
2294:
2257:
2247:
2197:
2154:
2096:
2086:
2051:
2031:
1988:
1614:
1232:
Based on the hydrolytic mechanism of fatty acid amide hydrolase, a large number of
1218:
989:
354:
285:
229:
184:
89:
4324:
4009:
Habib AM, Okorokov AL, Hill MN, Bras JT, Lee MC, Li S, et al. (August 2019).
3657:
3586:
3154:
2535:
2520:"The endocannabinoid system as a potential therapeutic target for pain modulation"
6548:
6532:
6445:
4133:
3070:
1752:
1736:
1479:
1226:
1180:
1164:, it is currently viewed as an attractive drug target for the treatment of pain.
1146:
1067:
329:
113:
3811:
rs324420 (C385A) Polymorphism with High-Level
Performance in Volleyball Players"
3553:
1941:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1923:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1699:(lncRNA) that increases the expression of FAAH. In 2019, a Scottish woman named
6697:
6586:
6527:
6347:
6310:
6282:
6234:
6229:
6216:
6166:
6128:
5974:
5959:
5129:
5029:
4615:
4425:
4230:
Proceedings of the
National Academy of Sciences of the United States of America
3706:
3634:
3412:
Proceedings of the National Academy of Sciences of the United States of America
3278:
Proceedings of the National Academy of Sciences of the United States of America
3035:
3000:
2731:
2685:
2496:
2232:
Proceedings of the National Academy of Sciences of the United States of America
2071:
Proceedings of the National Academy of Sciences of the United States of America
1716:
deletion but has no C385A mutation, has a lesser degree of pain insensitivity.
1385:
1138:
1122:
430:
4026:
3914:
3118:
3101:
2928:
2879:
1743:
expression), lack of depression and anxiety is instead due to a non-canonical
1664:) and the presence of the rs324420 C385A allele in citizens' genetic make-up.
6707:
6491:
6450:
6374:
6300:
6249:
5964:
5737:
5254:
5162:
4909:
4686:
4651:
4575:
4530:
4182:
3922:
2670:"Amygdala FAAH and anandamide: mediating protection and recovery from stress"
1727:
increases the expression of FAAH, both via its lncRNA product and through an
1704:
1654:
1381:
532:
4250:
3964:
3805:
Silva HH, Tavares V, Silva MG, Neto BV, Cerqueira F, Medeiros R (May 2023).
3424:
3298:
3202:
2584:
2390:
2158:
1251:, palmitylsulfonyl fluoride, one of the first FAAH inhibitors developed for
490:
368:
6440:
6156:
6136:
5984:
5692:
5340:
4712:
4630:
4269:
4200:
4151:
4044:
3992:
3887:
3846:
3791:
3750:
3714:
3642:
3571:
3530:
3492:
3474:
3457:
Campos AC, Moreira FA, Gomes FV, Del Bel EA, GuimarĂŁes FS (December 2012).
3443:
3366:
3317:
3258:
3162:
3127:
3078:
3043:
3008:
2973:
2946:
2897:
2844:
2793:
2739:
2703:
2654:
2602:
2553:
2504:
2468:
2433:
2355:
2321:
2306:
2271:
2252:
2209:
2166:
2091:
2067:"Molecular characterization of human and mouse fatty acid amide hydrolases"
1771:
1549:
1465:
1455:
1320:
1265:
347:
126:
3827:
3240:
2398:
2110:
2043:
2000:
969:
6664:
6599:
6435:
6224:
6151:
6141:
6017:
5722:
5672:
5667:
5562:
5537:
5461:
5456:
5370:
5335:
5172:
5090:
5059:
5014:
4934:
4899:
4792:
4732:
4727:
4707:
4661:
4610:
4480:
4435:
3782:
3548:. Handbook of Experimental Pharmacology. Vol. 231. pp. 95–128.
2825:
1766:
The enzyme is typically assayed making use of a radiolabelled anandamide
1744:
1631:
1489:
1331:
1271:
1161:
812:
793:
4313:
3405:
2774:
1825:
964:
6379:
6262:
6179:
5707:
5702:
5547:
5542:
5495:
5426:
5416:
5365:
5167:
5115:
5110:
5105:
4929:
4904:
4894:
4772:
4737:
4722:
4676:
4671:
4666:
4485:
4470:
3973:
1700:
1688:
1682:
1646:
1544:
1326:
1176:
1137:
KOs have an analgesic phenotype, showing reduced pain sensation in the
1059:
1045:
1027:
997:
246:
143:
93:
4218:
3878:
3861:
3522:
2460:
2425:
2347:
2201:
2131:
6638:
6612:
6355:
6110:
5677:
5274:
5039:
5019:
4984:
4979:
4974:
4924:
4864:
4859:
4854:
4762:
4757:
4747:
4717:
4580:
4570:
4500:
4495:
2411:
2035:
1758:
levels; the non-canonical Wnt pathway is also beneficial to healing.
1635:
1435:
1172:
1154:
1023:
667:
313:
300:
212:
199:
101:
6109:
1149:. Finally, because of their impaired ability to degrade anandamide,
6692:
6257:
5979:
5095:
5009:
4989:
4944:
4919:
4681:
4635:
4605:
4585:
4535:
4525:
3859:
2368:
1279:
1102:
1037:
953:
4074:"At 71, She's Never Felt Pain or Anxiety. Now Scientists Know Why"
1055:
called the fatty acid amides (FAAs). Members of the FAAs include:
6199:
5946:
5727:
5203:
5100:
5085:
5024:
4999:
4969:
4959:
4954:
4949:
4889:
4884:
4879:
4874:
4742:
4702:
4656:
4590:
4560:
4555:
4550:
4545:
4465:
4460:
4455:
4450:
4445:
3949:"Molecular basis of FAAH-OUT-associated human pain insensitivity"
3333:"Preclinical Characterization of the FAAH Inhibitor JNJ-42165279"
1609:
1573:
1371:
1341:
1041:
779:
734:
652:
648:
5868:
4128:. Methods in Molecular Biology. Vol. 572. pp. 247–59.
4100:"Scientists find genetic mutation that makes woman feel no pain"
3946:
81:
6651:
6421:
6146:
5947:
5858:
5823:
5818:
5767:
5697:
5611:
5582:
5577:
5395:
5360:
5304:
5208:
5187:
5080:
5034:
4994:
4939:
4849:
4767:
4752:
4625:
4600:
4565:
4540:
4430:
2284:
2225:
1774:, although alternative LC-MS methods have also been described.
1728:
1597:
1427:
1048:
993:
937:
689:
2668:
Gunduz-Cinar O, Hill MN, McEwen BS, Holmes A (November 2013).
6625:
6325:
5869:
5657:
5517:
5223:
4914:
4787:
4490:
2319:
1834:
1740:
1585:
1052:
3508:
2667:
6189:
6161:
5803:
5682:
3692:
1782:
The first crystal structure of FAAH was published in 2002 (
1748:
1537:
1275:
1222:
1008:
6390:
2716:
4223:
4164:
3456:
2807:
Shin KO, Kim S, Park BD, Uchida Y, Park K (August 2021).
2618:
2573:
The Journal of Pharmacology and Experimental Therapeutics
2136:
2013:
3866:
Scandinavian Journal of Medicine & Science in Sports
2986:
2857:
1243:
Some of the more significant compounds are listed below;
337:
4053:"Woman with novel gene mutation lives almost pain-free"
3620:
3271:
3140:
5394:
5130:
4320:
Fatty acid amide hydrolase (FAAH1) Human Protein Atlas
4316:- interactive structure (JMOL) of inhibitor-bound FAAH
6681:
5222:
5135:
4008:
3804:
3727:
3330:
502:
4126:
Ligand-Macromolecular Interactions in Drug Discovery
2619:
Panlilio LV, Justinova Z, Goldberg SR (April 2013).
5497:
4807:
4384:
4354:
2566:
2481:
441:
dentate gyrus of hippocampal formation granule cell
5629:
3186:"More Details Emerge on Fateful French Drug Trial"
2756:Hayes AC, Stupak J, Li J, Cox AD (February 2013).
2614:
2612:
1897:
1895:
1893:
1876:
1874:
1872:
1821:numbering scheme, "fatty acid amide hydrolase" is
3450:
3056:
2959:
2910:
2806:
2187:
1719:A 2023 study looks further into the functions of
1157:anandamide, a cannabinoid receptor (CB) agonist.
284:
183:
6705:
2755:
2320:Saghatelian A, Trauger SA, Want EJ, Hawkins EG,
1125:display highly elevated (>15-fold) levels of
4004:
4002:
3942:
3940:
3504:
3502:
3225:"Chemical probes of endocannabinoid metabolism"
3222:
3021:
2609:
2446:
2221:
2219:
1890:
1869:
1703:was found to have both a previously unreported
1503:increases the production and activity of FAAH.
1495:
1240:inhibitors of this enzyme have been developed.
1007:(NAE) in 1993. In humans, it is encoded by the
3383:. Janssen.com. 17 January 2016. Archived from
2122:
2120:
1902:GRCm38: Ensembl release 89: ENSMUSG00000034171
1201:
6406:
6095:
4340:
3024:CNS & Neurological Disorders Drug Targets
2751:
2749:
6043:(FAAH-like anandamide transporter inhibitor)
6031:(directly potentiates activity of 2-AG at CB
4207:
4158:
4117:
3999:
3937:
3731:Bioorganic & Medicinal Chemistry Letters
3695:Bioorganic & Medicinal Chemistry Letters
3686:
3623:Bioorganic & Medicinal Chemistry Letters
3614:
3537:
3499:
3324:
3265:
3216:
3134:
3093:
3050:
3015:
2980:
2953:
2904:
2851:
2710:
2661:
2560:
2511:
2475:
2440:
2405:
2313:
2216:
2181:
2064:
2911:Ahn K, Johnson DS, Cravatt BF (July 2009).
2813:International Journal of Molecular Sciences
2485:European Journal of Pharmaceutical Sciences
2362:
2117:
1978:
1881:GRCh38: Ensembl release 89: ENSG00000117480
32:"FAAH" redirects here. For other uses, see
6413:
6399:
6102:
6088:
4347:
4333:
3900:
2746:
2058:
2007:
1972:
68:, fatty acid amide hydrolase, FAAH-1, PSAB
4306:at the U.S. National Library of Medicine
4259:
4249:
4190:
4123:
4034:
3982:
3972:
3877:
3836:
3826:
3781:
3482:
3433:
3423:
3356:
3307:
3297:
3248:
3117:
2936:
2887:
2834:
2824:
2800:
2783:
2773:
2693:
2644:
2592:
2543:
2337:
2261:
2251:
2100:
2090:
1671:
1473:
1434:), is an irreversible inactivator with a
1111:-acyltaurines, which are agonists of the
1044:activity. In vivo, FAAH is the principal
3183:
3106:The Proceedings of the Nutrition Society
2962:Current Opinion in Investigational Drugs
1812:
5404:
3099:
1160:Due to the ability of FAAH to regulate
27:Mammalian protein found in Homo sapiens
14:
6706:
4097:
4071:
3543:
3223:Blankman JL, Cravatt BF (April 2013).
2517:
1947:
1225:, inhibit FAAH, and thereby increases
6394:
6331:Activation-induced cytidine deaminase
6083:
4328:
3143:Expert Opinion on Therapeutic Patents
2989:Current Topics in Medicinal Chemistry
1712:no scarring. Her son, who shares the
1153:KOs also display supersensitivity to
289:
250:
245:
188:
147:
142:
5738:Redafamdastat (JZP-150, PF-04457845)
3763:
5502:Tooltip Endocannabinoid transporter
4815:Tooltip Cannabinoid receptor type 2
4392:Tooltip Cannabinoid receptor type 1
2065:Giang DK, Cravatt BF (March 1997).
1506:
1255:use, but too reactive for research
996:. It was first shown to break down
561:fatty acid amide hydrolase activity
24:
5634:Tooltip Fatty acid amide hydrolase
2868:International Review of Psychiatry
2674:Trends in Pharmacological Sciences
1853:Endocannabinoid reuptake inhibitor
1731:enhancer called FAAH-AMP. Loss of
638:monoacylglycerol catabolic process
628:arachidonic acid metabolic process
25:
6740:
4297:
1794:
1115:(TRP) family of calcium channels.
6691:
4059:(Press release). March 27, 2019.
3059:Expert Opinion on Drug Discovery
2917:Expert Opinion on Drug Discovery
2637:10.1016/j.pharmthera.2013.01.003
1770:, which generates free labelled
1194:(NAE's) and their activation of
273:
266:
260:
237:
172:
165:
159:
134:
6113:: carbon-nitrogen non-peptide (
4276:
4091:
4065:
3894:
3853:
3798:
3757:
3721:
3667:
3649:
3604:"Clinical trials for SSR411298"
3596:
3578:
3399:
3373:
3337:ACS Medicinal Chemistry Letters
3177:
2625:Pharmacology & Therapeutics
2287:Chemistry and Physics of Lipids
2278:
1527:C385A, c.385C>A, p.Pro129Thr
1066:-arachidonoylethanolamine), an
6306:Inosine monophosphate synthase
5980:Orlistat (tetrahydrolipstatin)
4015:British Journal of Anaesthesia
3770:British Journal of Anaesthesia
3349:10.1021/acsmedchemlett.5b00353
1929:
1911:
1695:coding region. It expresses a
1628:single nucleotide polymorphism
1414:, reversible inhibitor of FAAH
602:endoplasmic reticulum membrane
592:integral component of membrane
491:More reference expression data
395:right hemisphere of cerebellum
13:
1:
6060:Receptor/signaling modulators
4531:Gallocatechol (gallocatechin)
3743:10.1016/S0960-894X(98)00734-3
3155:10.1517/13543776.2015.1067683
2536:10.5152/balkanmedj.2014.13103
2299:10.1016/S0009-3084(00)00190-0
1863:
1789:
1777:
1022:FAAH is an integral membrane
258:
157:
4134:10.1007/978-1-60761-244-5_16
3903:Journal of Happiness Studies
3100:Pertwee RG (February 2014).
3071:10.1517/17460441.2013.780021
1993:10.1016/0006-2952(93)90486-G
1496:Enhancement of FAAH activity
1113:transient receptor potential
982:Fatty-acid amide hydrolase 1
633:fatty acid catabolic process
556:acylglycerol lipase activity
7:
6714:Genes on human chromosome 1
6420:
6069:(cannabinoids by structure)
5723:Paracetamol (acetaminophen)
5563:Paracetamol (acetaminophen)
3608:EU Clinical Trials Register
3554:10.1007/978-3-319-20825-1_4
1841:
1511:
1268:, dual FAAH / COX inhibitor
1202:Inhibitors and inactivators
1075:(2-AG), an endocannabinoid.
1017:
379:right lobe of thyroid gland
10:
6745:
6729:Integral membrane proteins
6268:Protein-arginine deiminase
6190:Fatty acid amide hydrolase
4304:fatty-acid+amide+hydrolase
4098:Sample I (28 March 2019).
4072:Murphy H (28 March 2019).
3707:10.1016/j.bmcl.2011.12.032
3635:10.1016/j.bmcl.2009.05.097
3036:10.2174/187152711796234989
3001:10.2174/156802610791164238
2732:10.1016/j.phrs.2016.07.024
2686:10.1016/j.tips.2013.08.008
2497:10.1016/j.ejps.2013.11.012
1809:-acylethanolamine levels.
1680:
1634:degradation and a shorter
387:mucosa of transverse colon
383:left lobe of thyroid gland
31:
6577:
6569:Michaelis–Menten kinetics
6541:
6510:
6479:
6428:
6364:
6341:
6276:
6243:
6210:
6122:
6051:
5997:
5945:
5867:
5786:
5645:4-Nonylphenylboronic acid
5627:
5610:
5478:
5393:
5328:
5232:
5221:
5196:
5145:
5128:
5068:
4822:
4805:
4695:
4644:
4399:
4382:
4365:
4027:10.1016/j.bja.2019.02.019
3915:10.1007/s10902-015-9712-y
3119:10.1017/S0029665113003649
2929:10.1517/17460440903018857
2880:10.1080/09540260902782778
2762:Journal of Lipid Research
1937:"Mouse PubMed Reference:"
1919:"Human PubMed Reference:"
1761:
1626:The FAAH gene contains a
1620:
1608:
1596:
1584:
1572:
1568:
1563:
1555:
1543:
1531:
1523:
1518:
1101:The sleep-inducing lipid
1051:for a class of bioactive
968:
963:
959:
952:
936:
930:Chr 4: 115.82 – 115.88 Mb
917:
902:
898:
881:
877:
870:
855:
851:
834:
830:
823:
810:
806:
791:
787:
778:
765:
761:
746:
742:
733:
720:
716:
701:
697:
688:
673:
666:
662:
646:
531:
527:
515:
510:
501:
488:
437:
428:
375:
366:
336:
328:
324:
307:
294:
257:
236:
227:
223:
206:
193:
156:
133:
124:
120:
75:
72:
62:
55:
50:
46:
41:
6461:Diffusion-limited enzyme
6008:Phosphatidylethanolamine
5285:Lysophosphatidylinositol
4723:Falcarinol (carotatoxin)
4308:Medical Subject Headings
4183:10.1016/j.ab.2012.09.031
2720:Pharmacological Research
1981:Biochemical Pharmacology
1848:Endocannabinoid enhancer
1802:Dictyostelium discoideum
1171:, as inhibition produce
6185:Aspartylglucosaminidase
5718:Palmitoylisopropylamide
4284:"KEGG ENZYME: 3.5.1.99"
4251:10.1073/pnas.0806121105
4171:Analytical Biochemistry
3425:10.1073/pnas.0507470102
3299:10.1073/pnas.1016167108
3229:Pharmacological Reviews
3203:10.1126/science.aae0247
2858:Janero DR, Vadivel SK,
2585:10.1124/jpet.115.222851
2449:Journal of Neurobiology
2391:10.1126/science.7770779
2159:10.1126/science.1076535
1858:Monoacylglycerol lipase
1649:(AEA) signaling at the
1129:-acylethanolamines and
923:Chr 1: 46.39 – 46.41 Mb
5663:Arachidonoyl serotonin
5528:Arachidonoyl serotonin
4930:GW-405,833 (L-768,242)
4314:Proteopedia FAAH entry
3675:US granted 8450346
3655:Clinical trial number
3584:Clinical trial number
3475:10.1098/rstb.2011.0389
2524:Balkan Medical Journal
2518:Ulugöl A (June 2014).
2253:10.1073/pnas.161191698
2092:10.1073/pnas.94.6.2238
1474:Inhibition and binding
1432:Kadmus Pharmaceuticals
1097:-palmitoylethanolamine
1073:2-arachidonoylglycerol
461:superior frontal gyrus
6554:Eadie–Hofstee diagram
6487:Allosteric regulation
5315:Palmitoylethanolamide
5240:2-AGE (noladin ether)
4840:3,3'-Diindolylmethane
4835:2-AGE (noladin ether)
4421:2-AGE (noladin ether)
3965:10.1093/brain/awad098
3828:10.3390/genes14061164
3241:10.1124/pr.112.006387
1813:Enzyme classification
1651:cannabinoid receptors
1196:cannabinoid receptors
1036:. In vitro, FAAH has
988:) is a member of the
449:primary visual cortex
34:FAAH (disambiguation)
6719:SNPs on chromosome 1
6564:Lineweaver–Burk plot
6316:GTP cyclohydrolase I
5250:Abnormal cannabidiol
5153:Abnormal cannabidiol
4985:Lenabasum (anabasum)
4356:Cannabinoid receptor
2826:10.3390/ijms22158302
1208:cannabinoid receptor
1187:effects by elevated
1034:transmembrane domain
291:4 D1|4 53.08 cM
252:Chromosome 4 (mouse)
150:Chromosome 1 (human)
6296:Adenosine deaminase
6195:Histone deacetylase
4850:α-Amyrin · β-Amyrin
4506:Dimethylheptylpyran
4431:α-Amyrin · β-Amyrin
4242:2008PNAS..10512820M
4236:(35): 12820–12824.
3517:(45): 13019–13030.
3469:(1607): 3364–3378.
3418:(49): 17852–17857.
3290:2011PNAS..108.7379M
3184:Enserink M (2016).
2775:10.1194/jlr.M032219
2383:1995Sci...268.1506C
2377:(5216): 1506–1509.
2332:(45): 14332–14339.
2244:2001PNAS...98.9371C
2196:(43): 14125–14130.
2151:2002Sci...298.1793B
2145:(5599): 1793–1796.
2083:1997PNAS...94.2238G
2028:1996Natur.384...83C
1739:levels and reduced
1697:long non-coding RNA
1662:World Values Survey
1090:-oleoylethanolamine
607:endomembrane system
407:right lobe of liver
6523:Enzyme superfamily
6456:Enzyme promiscuity
6321:Cytidine deaminase
6280:: Cyclic amidines/
6247:: Linear amidines/
5447:Oleoylethanolamide
5381:Tetrahydromagnolol
5310:Oleoylethanolamide
5076:4-O-Methylhonokiol
5055:Tetrahydromagnolol
5010:Olorinab (APD-371)
4845:4-O-Methylhonokiol
4078:The New York Times
3783:10.1093/bja/aeq117
3663:ClinicalTrials.gov
3592:ClinicalTrials.gov
3387:on 25 January 2016
1691:downstream of the
1564:External databases
1501:Insulin medication
1206:Activation of the
1192:-acylethanolamines
1083:-acylethanolamines
768:ENSMUSG00000034171
621:Biological process
587:organelle membrane
575:Cellular component
551:hydrolase activity
539:Molecular function
477:hippocampus proper
445:left lobe of liver
6679:
6678:
6388:
6387:
6291:Guanine deaminase
6126:: Linear amides /
6077:
6076:
5993:
5992:
5606:
5605:
5474:
5473:
5470:
5469:
5389:
5388:
5217:
5216:
5124:
5123:
4801:
4800:
4143:978-1-60761-243-8
3879:10.1111/sms.12687
3629:(15): 4241–4244.
3563:978-3-319-20824-4
3523:10.1021/bi701378g
3343:(12): 1204–1208.
3284:(18): 7379–7384.
3149:(11): 1247–1266.
2461:10.1002/neu.20080
2426:10.1021/bi0608008
2420:(30): 9007–9015.
2348:10.1021/bi0480335
2238:(16): 9371–9376.
2202:10.1021/bi991876p
1819:Enzyme Commission
1645:(NAE) levels and
1643:-acylethanolamine
1624:
1623:
1185:anti-inflammatory
1169:anxiety disorders
1005:-acylethanolamine
979:
978:
975:
974:
948:
947:
913:
912:
892:
891:
866:
865:
845:
844:
819:
818:
800:
799:
774:
773:
755:
754:
729:
728:
710:
709:
658:
657:
523:
522:
519:
518:
497:
496:
484:
483:
465:entorhinal cortex
457:perirhinal cortex
422:
421:
411:nucleus accumbens
320:
319:
219:
218:
16:(Redirected from
6736:
6696:
6695:
6687:
6559:Hanes–Woolf plot
6502:Enzyme activator
6497:Enzyme inhibitor
6471:Enzyme catalysis
6415:
6408:
6401:
6392:
6391:
6214:: Cyclic amides/
6104:
6097:
6090:
6081:
6080:
5950:
5872:
5635:
5631:
5625:
5624:
5621:
5503:
5499:
5493:
5492:
5489:
5442:N-Oleoyldopamine
5412:2-Oleoylglycerol
5402:
5401:
5398:
5320:THC (dronabinol)
5230:
5229:
5226:
5183:THC (dronabinol)
5143:
5142:
5137:
5132:
5045:THC (dronabinol)
4820:
4819:
4816:
4812:
4645:Inverse agonists
4621:THC (dronabinol)
4397:
4396:
4393:
4389:
4380:
4379:
4376:
4349:
4342:
4335:
4326:
4325:
4292:
4291:
4280:
4274:
4273:
4263:
4253:
4221:
4211:
4205:
4204:
4194:
4162:
4156:
4155:
4121:
4115:
4114:
4112:
4110:
4095:
4089:
4088:
4086:
4084:
4069:
4063:
4060:
4048:
4038:
4021:(2): e249–e253.
4006:
3997:
3996:
3986:
3976:
3959:(9): 3851–3865.
3944:
3935:
3934:
3898:
3892:
3891:
3881:
3857:
3851:
3850:
3840:
3830:
3807:"Association of
3802:
3796:
3795:
3785:
3761:
3755:
3754:
3725:
3719:
3718:
3690:
3684:
3683:
3682:
3678:
3671:
3665:
3653:
3647:
3646:
3618:
3612:
3611:
3600:
3594:
3582:
3576:
3575:
3546:Endocannabinoids
3541:
3535:
3534:
3506:
3497:
3496:
3486:
3454:
3448:
3447:
3437:
3427:
3403:
3397:
3396:
3394:
3392:
3377:
3371:
3370:
3360:
3328:
3322:
3321:
3311:
3301:
3269:
3263:
3262:
3252:
3220:
3214:
3213:
3211:
3209:
3190:
3181:
3175:
3174:
3138:
3132:
3131:
3121:
3097:
3091:
3090:
3054:
3048:
3047:
3019:
3013:
3012:
2984:
2978:
2977:
2957:
2951:
2950:
2940:
2908:
2902:
2901:
2891:
2855:
2849:
2848:
2838:
2828:
2804:
2798:
2797:
2787:
2777:
2753:
2744:
2743:
2714:
2708:
2707:
2697:
2665:
2659:
2658:
2648:
2616:
2607:
2606:
2596:
2564:
2558:
2557:
2547:
2515:
2509:
2508:
2479:
2473:
2472:
2444:
2438:
2437:
2409:
2403:
2402:
2366:
2360:
2359:
2341:
2317:
2311:
2310:
2293:(1–2): 107–121.
2282:
2276:
2275:
2265:
2255:
2223:
2214:
2213:
2185:
2179:
2178:
2134:
2124:
2115:
2114:
2104:
2094:
2077:(6): 2238–2242.
2062:
2056:
2055:
2036:10.1038/384083a0
2011:
2005:
2004:
1976:
1970:
1969:
1967:
1965:
1951:
1945:
1944:
1933:
1927:
1926:
1915:
1909:
1899:
1888:
1878:
1676:
1675:
1516:
1515:
1507:Genetic variants
1264:, derivative of
990:serine hydrolase
961:
960:
932:
925:
908:
896:
895:
887:
875:
874:
871:RefSeq (protein)
861:
849:
848:
840:
828:
827:
804:
803:
785:
784:
759:
758:
740:
739:
714:
713:
695:
694:
664:
663:
566:amidase activity
529:
528:
508:
507:
493:
433:
431:Top expressed in
426:
425:
415:body of pancreas
371:
369:Top expressed in
364:
363:
343:
342:
326:
325:
316:
303:
292:
277:
270:
264:
253:
241:
225:
224:
215:
202:
191:
176:
169:
163:
152:
138:
122:
121:
116:
114:FAAH - orthologs
67:
60:
39:
38:
21:
6744:
6743:
6739:
6738:
6737:
6735:
6734:
6733:
6704:
6703:
6702:
6690:
6682:
6680:
6675:
6587:Oxidoreductases
6573:
6549:Enzyme kinetics
6537:
6533:List of enzymes
6506:
6475:
6446:Catalytic triad
6424:
6419:
6389:
6384:
6360:
6348:Aminohydrolases
6346:
6337:
6283:Aminohydrolases
6281:
6272:
6248:
6239:
6217:Amidohydrolases
6215:
6206:
6129:Amidohydrolases
6127:
6118:
6108:
6078:
6073:
6047:
6034:
5989:
5941:
5863:
5782:
5653:
5633:
5615:
5614:
5602:
5501:
5483:
5482:
5466:
5385:
5324:
5213:
5192:
5133:
5120:
5064:
4814:
4811:
4797:
4691:
4640:
4404:
4401:
4391:
4388:
4370:
4369:
4361:
4353:
4300:
4295:
4282:
4281:
4277:
4213:
4212:
4208:
4163:
4159:
4144:
4122:
4118:
4108:
4106:
4096:
4092:
4082:
4080:
4070:
4066:
4051:
4007:
4000:
3945:
3938:
3899:
3895:
3858:
3854:
3803:
3799:
3764:Weis F (2010).
3762:
3758:
3726:
3722:
3691:
3687:
3680:
3672:
3668:
3654:
3650:
3619:
3615:
3602:
3601:
3597:
3583:
3579:
3564:
3542:
3538:
3507:
3500:
3455:
3451:
3404:
3400:
3390:
3388:
3379:
3378:
3374:
3329:
3325:
3270:
3266:
3221:
3217:
3207:
3205:
3188:
3182:
3178:
3139:
3135:
3098:
3094:
3055:
3051:
3020:
3016:
2985:
2981:
2958:
2954:
2909:
2905:
2856:
2852:
2805:
2801:
2754:
2747:
2715:
2711:
2680:(11): 637–644.
2666:
2662:
2617:
2610:
2565:
2561:
2516:
2512:
2480:
2476:
2445:
2441:
2410:
2406:
2367:
2363:
2318:
2314:
2283:
2279:
2224:
2217:
2186:
2182:
2126:
2125:
2118:
2063:
2059:
2022:(6604): 83–87.
2012:
2008:
1977:
1973:
1963:
1961:
1959:www.uniprot.org
1953:
1952:
1948:
1935:
1934:
1930:
1917:
1916:
1912:
1900:
1891:
1879:
1870:
1866:
1844:
1815:
1799:The slime mold
1797:
1792:
1780:
1764:
1737:endocannabinoid
1685:
1679:
1673:
1672:
1514:
1509:
1498:
1480:stereochemistry
1476:
1471:
1227:endocannabinoid
1204:
1181:neuroprotective
1147:tail flick test
1068:endocannabinoid
1020:
970:View/Edit Mouse
965:View/Edit Human
928:
921:
918:Location (UCSC)
904:
883:
857:
836:
749:ENSG00000117480
642:
616:
570:
546:protein binding
489:
480:
475:
471:
467:
463:
459:
455:
451:
447:
443:
429:
418:
413:
409:
405:
401:
397:
393:
389:
385:
381:
367:
311:
298:
290:
280:
279:
278:
271:
251:
228:Gene location (
210:
197:
189:
179:
178:
177:
170:
148:
125:Gene location (
76:
63:
56:
37:
28:
23:
22:
15:
12:
11:
5:
6742:
6732:
6731:
6726:
6721:
6716:
6701:
6700:
6677:
6676:
6674:
6673:
6660:
6647:
6634:
6621:
6608:
6595:
6581:
6579:
6575:
6574:
6572:
6571:
6566:
6561:
6556:
6551:
6545:
6543:
6539:
6538:
6536:
6535:
6530:
6525:
6520:
6514:
6512:
6511:Classification
6508:
6507:
6505:
6504:
6499:
6494:
6489:
6483:
6481:
6477:
6476:
6474:
6473:
6468:
6463:
6458:
6453:
6448:
6443:
6438:
6432:
6430:
6426:
6425:
6418:
6417:
6410:
6403:
6395:
6386:
6385:
6383:
6382:
6377:
6371:
6369:
6362:
6361:
6359:
6358:
6352:
6350:
6339:
6338:
6336:
6335:
6334:
6333:
6328:
6318:
6313:
6311:DCMP deaminase
6308:
6303:
6298:
6293:
6287:
6285:
6274:
6273:
6271:
6270:
6265:
6260:
6254:
6252:
6250:Ureohydrolases
6241:
6240:
6238:
6237:
6235:Dihydroorotase
6232:
6230:Beta-lactamase
6227:
6221:
6219:
6208:
6207:
6205:
6204:
6203:
6202:
6192:
6187:
6182:
6177:
6176:
6175:
6170:
6167:Aspartoacylase
6164:
6154:
6149:
6144:
6139:
6133:
6131:
6120:
6119:
6107:
6106:
6099:
6092:
6084:
6075:
6074:
6072:
6071:
6063:
6056:
6052:
6049:
6048:
6046:
6045:
6037:
6032:
6021:
6020:
6018:Diacylglycerol
6015:
6010:
6001:
5999:
5995:
5994:
5991:
5990:
5988:
5987:
5982:
5977:
5975:Oleanolic acid
5972:
5967:
5962:
5960:Betulinic acid
5953:
5951:
5943:
5942:
5940:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5904:
5899:
5894:
5889:
5884:
5875:
5873:
5865:
5864:
5862:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5826:
5821:
5816:
5811:
5806:
5801:
5792:
5790:
5784:
5783:
5781:
5780:
5771:
5770:
5765:
5760:
5755:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5715:
5710:
5705:
5700:
5695:
5690:
5685:
5680:
5675:
5670:
5665:
5660:
5655:
5651:
5647:
5638:
5636:
5622:
5608:
5607:
5604:
5603:
5601:
5600:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5560:
5555:
5550:
5545:
5540:
5535:
5530:
5525:
5520:
5515:
5506:
5504:
5490:
5476:
5475:
5472:
5471:
5468:
5467:
5465:
5464:
5459:
5454:
5449:
5444:
5439:
5434:
5429:
5424:
5419:
5414:
5408:
5406:
5399:
5391:
5390:
5387:
5386:
5384:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5343:
5338:
5332:
5330:
5326:
5325:
5323:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5236:
5234:
5227:
5219:
5218:
5215:
5214:
5212:
5211:
5206:
5200:
5198:
5194:
5193:
5191:
5190:
5185:
5180:
5175:
5170:
5165:
5160:
5155:
5149:
5147:
5140:
5126:
5125:
5122:
5121:
5119:
5118:
5113:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5072:
5070:
5066:
5065:
5063:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5030:Serinolamide A
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4942:
4937:
4932:
4927:
4922:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4852:
4847:
4842:
4837:
4832:
4826:
4824:
4817:
4809:
4803:
4802:
4799:
4798:
4796:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4705:
4699:
4697:
4693:
4692:
4690:
4689:
4684:
4679:
4674:
4669:
4664:
4659:
4654:
4648:
4646:
4642:
4641:
4639:
4638:
4633:
4628:
4623:
4618:
4616:Serinolamide A
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4426:11-Hydroxy-THC
4423:
4418:
4412:
4410:
4394:
4386:
4377:
4363:
4362:
4352:
4351:
4344:
4337:
4329:
4323:
4322:
4317:
4311:
4299:
4298:External links
4296:
4294:
4293:
4275:
4206:
4157:
4142:
4116:
4090:
4064:
4062:
4061:
3998:
3936:
3909:(2): 321–340.
3893:
3872:(8): 788–800.
3852:
3797:
3776:(2): 139–144.
3756:
3737:(2): 265–270.
3720:
3701:(2): 901–906.
3685:
3666:
3648:
3613:
3595:
3577:
3562:
3536:
3498:
3449:
3398:
3372:
3323:
3264:
3235:(2): 849–871.
3215:
3197:(January 16).
3176:
3133:
3092:
3065:(5): 509–522.
3049:
3030:(5): 545–558.
3014:
2995:(8): 828–858.
2979:
2952:
2923:(7): 763–784.
2903:
2874:(2): 122–133.
2862:(April 2009).
2850:
2799:
2768:(2): 457–466.
2745:
2709:
2660:
2608:
2579:(2): 111–120.
2559:
2530:(2): 115–120.
2510:
2474:
2455:(1): 149–160.
2439:
2404:
2361:
2339:10.1.1.334.206
2312:
2277:
2215:
2180:
2116:
2057:
2006:
1987:(5): 791–796.
1971:
1946:
1928:
1910:
1889:
1867:
1865:
1862:
1861:
1860:
1855:
1850:
1843:
1840:
1814:
1811:
1796:
1795:In slime molds
1793:
1791:
1788:
1779:
1776:
1763:
1760:
1687:FAAH-OUT is a
1681:Main article:
1678:
1670:
1622:
1621:
1618:
1617:
1612:
1606:
1605:
1600:
1594:
1593:
1588:
1582:
1581:
1576:
1570:
1569:
1566:
1565:
1561:
1560:
1557:
1553:
1552:
1547:
1541:
1540:
1535:
1529:
1528:
1525:
1521:
1520:
1513:
1510:
1508:
1505:
1497:
1494:
1475:
1472:
1470:
1469:
1459:
1449:
1444:
1439:
1425:
1420:
1415:
1409:
1403:
1398:
1393:
1388:
1386:osteoarthritis
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:& Ca. SA,
1269:
1259:
1245:
1203:
1200:
1139:hot plate test
1117:
1116:
1105:
1099:
1076:
1070:
1026:with a single
1019:
1016:
977:
976:
973:
972:
967:
957:
956:
950:
949:
946:
945:
943:
941:
934:
933:
926:
919:
915:
914:
911:
910:
900:
899:
893:
890:
889:
879:
878:
872:
868:
867:
864:
863:
853:
852:
846:
843:
842:
832:
831:
825:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
772:
771:
763:
762:
756:
753:
752:
744:
743:
737:
731:
730:
727:
726:
718:
717:
711:
708:
707:
699:
698:
692:
686:
685:
680:
675:
671:
670:
660:
659:
656:
655:
644:
643:
641:
640:
635:
630:
624:
622:
618:
617:
615:
614:
609:
604:
599:
594:
589:
584:
578:
576:
572:
571:
569:
568:
563:
558:
553:
548:
542:
540:
536:
535:
525:
524:
521:
520:
517:
516:
513:
512:
505:
499:
498:
495:
494:
486:
485:
482:
481:
479:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
435:
434:
423:
420:
419:
417:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
373:
372:
360:
359:
351:
340:
334:
333:
330:RNA expression
322:
321:
318:
317:
309:
305:
304:
296:
293:
288:
282:
281:
272:
265:
259:
255:
254:
249:
243:
242:
234:
233:
221:
220:
217:
216:
208:
204:
203:
195:
192:
187:
181:
180:
171:
164:
158:
154:
153:
146:
140:
139:
131:
130:
118:
117:
74:
70:
69:
61:
53:
52:
48:
47:
44:
43:
26:
9:
6:
4:
3:
2:
6741:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6711:
6709:
6699:
6694:
6689:
6688:
6685:
6671:
6667:
6666:
6661:
6658:
6654:
6653:
6648:
6645:
6641:
6640:
6635:
6632:
6628:
6627:
6622:
6619:
6615:
6614:
6609:
6606:
6602:
6601:
6596:
6593:
6589:
6588:
6583:
6582:
6580:
6576:
6570:
6567:
6565:
6562:
6560:
6557:
6555:
6552:
6550:
6547:
6546:
6544:
6540:
6534:
6531:
6529:
6528:Enzyme family
6526:
6524:
6521:
6519:
6516:
6515:
6513:
6509:
6503:
6500:
6498:
6495:
6493:
6492:Cooperativity
6490:
6488:
6485:
6484:
6482:
6478:
6472:
6469:
6467:
6464:
6462:
6459:
6457:
6454:
6452:
6451:Oxyanion hole
6449:
6447:
6444:
6442:
6439:
6437:
6434:
6433:
6431:
6427:
6423:
6416:
6411:
6409:
6404:
6402:
6397:
6396:
6393:
6381:
6380:Thiaminase II
6378:
6376:
6375:Riboflavinase
6373:
6372:
6370:
6367:
6363:
6357:
6354:
6353:
6351:
6349:
6344:
6340:
6332:
6329:
6327:
6324:
6323:
6322:
6319:
6317:
6314:
6312:
6309:
6307:
6304:
6302:
6301:AMP deaminase
6299:
6297:
6294:
6292:
6289:
6288:
6286:
6284:
6279:
6275:
6269:
6266:
6264:
6261:
6259:
6256:
6255:
6253:
6251:
6246:
6242:
6236:
6233:
6231:
6228:
6226:
6223:
6222:
6220:
6218:
6213:
6209:
6201:
6198:
6197:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6174:
6171:
6168:
6165:
6163:
6160:
6159:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6134:
6132:
6130:
6125:
6121:
6116:
6112:
6105:
6100:
6098:
6093:
6091:
6086:
6085:
6082:
6070:
6068:
6064:
6062:
6061:
6057:
6054:
6053:
6050:
6044:
6041:
6038:
6036:
6029:
6026:
6023:
6022:
6019:
6016:
6014:
6011:
6009:
6006:
6003:
6002:
6000:
5996:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5966:
5965:Maslinic acid
5963:
5961:
5958:
5955:
5954:
5952:
5949:
5944:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5913:
5910:
5908:
5905:
5903:
5900:
5898:
5895:
5893:
5890:
5888:
5885:
5883:
5880:
5877:
5876:
5874:
5871:
5866:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5800:
5797:
5794:
5793:
5791:
5789:
5785:
5779:
5776:
5773:
5772:
5769:
5766:
5764:
5761:
5759:
5756:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5716:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5648:
5646:
5643:
5640:
5639:
5637:
5632:
5626:
5623:
5619:
5613:
5609:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5514:
5511:
5508:
5507:
5505:
5500:
5494:
5491:
5487:
5481:
5477:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5409:
5407:
5403:
5400:
5397:
5392:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5333:
5331:
5327:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5237:
5235:
5231:
5228:
5225:
5220:
5210:
5207:
5205:
5202:
5201:
5199:
5195:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5154:
5151:
5150:
5148:
5144:
5141:
5139:
5127:
5117:
5114:
5112:
5109:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5073:
5071:
5067:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4910:Caryophyllene
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4827:
4825:
4821:
4818:
4813:
4804:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4700:
4698:
4694:
4688:
4687:Zevaquenabant
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4649:
4647:
4643:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4576:Levonantradol
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4413:
4411:
4409:
4407:
4398:
4395:
4390:
4381:
4378:
4374:
4368:
4364:
4360:
4357:
4350:
4345:
4343:
4338:
4336:
4331:
4330:
4327:
4321:
4318:
4315:
4312:
4309:
4305:
4302:
4301:
4289:
4288:www.genome.jp
4285:
4279:
4271:
4267:
4262:
4257:
4252:
4247:
4243:
4239:
4235:
4231:
4227:
4220:
4216:
4210:
4202:
4198:
4193:
4188:
4184:
4180:
4176:
4172:
4168:
4161:
4153:
4149:
4145:
4139:
4135:
4131:
4127:
4120:
4105:
4101:
4094:
4079:
4075:
4068:
4058:
4054:
4050:
4049:
4046:
4042:
4037:
4032:
4028:
4024:
4020:
4016:
4012:
4005:
4003:
3994:
3990:
3985:
3980:
3975:
3970:
3966:
3962:
3958:
3954:
3950:
3943:
3941:
3932:
3928:
3924:
3920:
3916:
3912:
3908:
3904:
3897:
3889:
3885:
3880:
3875:
3871:
3867:
3863:
3856:
3848:
3844:
3839:
3834:
3829:
3824:
3820:
3816:
3812:
3810:
3801:
3793:
3789:
3784:
3779:
3775:
3771:
3767:
3760:
3752:
3748:
3744:
3740:
3736:
3732:
3724:
3716:
3712:
3708:
3704:
3700:
3696:
3689:
3676:
3670:
3664:
3660:
3659:
3652:
3644:
3640:
3636:
3632:
3628:
3624:
3617:
3609:
3605:
3599:
3593:
3589:
3588:
3581:
3573:
3569:
3565:
3559:
3555:
3551:
3547:
3540:
3532:
3528:
3524:
3520:
3516:
3512:
3505:
3503:
3494:
3490:
3485:
3480:
3476:
3472:
3468:
3464:
3460:
3453:
3445:
3441:
3436:
3431:
3426:
3421:
3417:
3413:
3409:
3402:
3386:
3382:
3376:
3368:
3364:
3359:
3354:
3350:
3346:
3342:
3338:
3334:
3327:
3319:
3315:
3310:
3305:
3300:
3295:
3291:
3287:
3283:
3279:
3275:
3268:
3260:
3256:
3251:
3246:
3242:
3238:
3234:
3230:
3226:
3219:
3204:
3200:
3196:
3195:
3187:
3180:
3172:
3168:
3164:
3160:
3156:
3152:
3148:
3144:
3137:
3129:
3125:
3120:
3115:
3112:(1): 96–105.
3111:
3107:
3103:
3096:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3060:
3053:
3045:
3041:
3037:
3033:
3029:
3025:
3018:
3010:
3006:
3002:
2998:
2994:
2990:
2983:
2975:
2971:
2967:
2963:
2956:
2948:
2944:
2939:
2934:
2930:
2926:
2922:
2918:
2914:
2907:
2899:
2895:
2890:
2885:
2881:
2877:
2873:
2869:
2865:
2861:
2860:Makriyannis A
2854:
2846:
2842:
2837:
2832:
2827:
2822:
2818:
2814:
2810:
2803:
2795:
2791:
2786:
2781:
2776:
2771:
2767:
2763:
2759:
2752:
2750:
2741:
2737:
2733:
2729:
2725:
2721:
2713:
2705:
2701:
2696:
2691:
2687:
2683:
2679:
2675:
2671:
2664:
2656:
2652:
2647:
2642:
2638:
2634:
2631:(1): 84–102.
2630:
2626:
2622:
2615:
2613:
2604:
2600:
2595:
2590:
2586:
2582:
2578:
2574:
2570:
2563:
2555:
2551:
2546:
2541:
2537:
2533:
2529:
2525:
2521:
2514:
2506:
2502:
2498:
2494:
2490:
2486:
2478:
2470:
2466:
2462:
2458:
2454:
2450:
2443:
2435:
2431:
2427:
2423:
2419:
2415:
2408:
2400:
2396:
2392:
2388:
2384:
2380:
2376:
2372:
2365:
2357:
2353:
2349:
2345:
2340:
2335:
2331:
2327:
2323:
2316:
2308:
2304:
2300:
2296:
2292:
2288:
2281:
2273:
2269:
2264:
2259:
2254:
2249:
2245:
2241:
2237:
2233:
2229:
2222:
2220:
2211:
2207:
2203:
2199:
2195:
2191:
2184:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2133:
2129:
2123:
2121:
2112:
2108:
2103:
2098:
2093:
2088:
2084:
2080:
2076:
2072:
2068:
2061:
2053:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2010:
2002:
1998:
1994:
1990:
1986:
1982:
1975:
1960:
1956:
1950:
1942:
1938:
1932:
1924:
1920:
1914:
1907:
1903:
1898:
1896:
1894:
1886:
1882:
1877:
1875:
1873:
1868:
1859:
1856:
1854:
1851:
1849:
1846:
1845:
1839:
1837:
1836:
1831:
1827:
1824:
1820:
1810:
1808:
1804:
1803:
1787:
1785:
1775:
1773:
1769:
1759:
1757:
1755:
1750:
1747:upregulating
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1717:
1715:
1710:
1706:
1705:microdeletion
1702:
1698:
1694:
1690:
1684:
1677:microdeletion
1669:
1665:
1663:
1658:
1656:
1652:
1648:
1644:
1642:
1637:
1633:
1629:
1619:
1616:
1613:
1611:
1607:
1604:
1601:
1599:
1595:
1592:
1589:
1587:
1583:
1580:
1579:Human SNPView
1577:
1575:
1571:
1567:
1562:
1558:
1554:
1551:
1548:
1546:
1542:
1539:
1536:
1534:
1530:
1526:
1522:
1519:SNP: rs324420
1517:
1504:
1502:
1493:
1491:
1488:
1485:
1481:
1467:
1463:
1460:
1457:
1453:
1450:
1448:
1445:
1443:
1440:
1437:
1433:
1429:
1426:
1424:
1421:
1419:
1416:
1413:
1410:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1383:
1382:Redafamdastat
1380:
1378:
1375:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1343:
1340:
1338:
1335:
1333:
1330:
1328:
1325:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1281:
1277:
1273:
1270:
1267:
1263:
1260:
1258:
1254:
1250:
1247:
1246:
1244:
1241:
1239:
1235:
1230:
1228:
1224:
1220:
1217:in different
1216:
1212:
1209:
1199:
1197:
1193:
1191:
1186:
1182:
1178:
1174:
1170:
1165:
1163:
1158:
1156:
1152:
1148:
1144:
1143:formalin test
1140:
1136:
1132:
1128:
1124:
1123:knockout mice
1121:
1114:
1110:
1106:
1104:
1100:
1098:
1096:
1091:
1089:
1084:
1082:
1077:
1074:
1071:
1069:
1065:
1061:
1058:
1057:
1056:
1054:
1050:
1047:
1043:
1039:
1035:
1032:
1030:
1025:
1015:
1013:
1010:
1006:
1004:
999:
995:
991:
987:
983:
971:
966:
962:
958:
955:
951:
944:
942:
939:
935:
931:
927:
924:
920:
916:
909:
907:
901:
897:
894:
888:
886:
880:
876:
873:
869:
862:
860:
854:
850:
847:
841:
839:
833:
829:
826:
824:RefSeq (mRNA)
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
770:
769:
764:
760:
757:
751:
750:
745:
741:
738:
736:
732:
725:
724:
719:
715:
712:
706:
705:
700:
696:
693:
691:
687:
684:
681:
679:
676:
672:
669:
665:
661:
654:
650:
645:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
588:
585:
583:
580:
579:
577:
574:
573:
567:
564:
562:
559:
557:
554:
552:
549:
547:
544:
543:
541:
538:
537:
534:
533:Gene ontology
530:
526:
514:
509:
506:
504:
500:
492:
487:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
439:
436:
432:
427:
424:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
377:
374:
370:
365:
362:
361:
358:
356:
352:
350:
349:
345:
344:
341:
339:
335:
331:
327:
323:
315:
310:
306:
302:
297:
287:
283:
276:
269:
263:
256:
248:
244:
240:
235:
231:
226:
222:
214:
209:
205:
201:
196:
186:
182:
175:
168:
162:
155:
151:
145:
141:
137:
132:
128:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
71:
66:
59:
54:
49:
45:
40:
35:
30:
19:
6665:Translocases
6662:
6649:
6636:
6623:
6610:
6600:Transferases
6597:
6584:
6441:Binding site
6157:Aminoacylase
6137:Asparaginase
6067:Cannabinoids
6065:
6058:
6042:
6030:
6024:
6004:
5985:Ursolic acid
5956:
5878:
5795:
5774:
5693:JNJ-42165279
5641:
5509:
5341:CID-16020046
4713:Cannabigerol
4631:WIN 55,212-2
4402:
4287:
4278:
4233:
4229:
4209:
4177:(2): 74–81.
4174:
4170:
4160:
4125:
4119:
4107:. Retrieved
4104:The Guardian
4103:
4093:
4081:. Retrieved
4077:
4067:
4057:ScienceDaily
4056:
4018:
4014:
3956:
3952:
3906:
3902:
3896:
3869:
3865:
3855:
3818:
3814:
3808:
3800:
3773:
3769:
3759:
3734:
3730:
3723:
3698:
3694:
3688:
3669:
3656:
3651:
3626:
3622:
3616:
3607:
3598:
3585:
3580:
3545:
3539:
3514:
3511:Biochemistry
3510:
3466:
3462:
3452:
3415:
3411:
3401:
3389:. Retrieved
3385:the original
3375:
3340:
3336:
3326:
3281:
3277:
3267:
3232:
3228:
3218:
3206:. Retrieved
3192:
3179:
3146:
3142:
3136:
3109:
3105:
3095:
3062:
3058:
3052:
3027:
3023:
3017:
2992:
2988:
2982:
2968:(1): 51–62.
2965:
2961:
2955:
2920:
2916:
2906:
2871:
2867:
2853:
2819:(15): 8302.
2816:
2812:
2802:
2765:
2761:
2723:
2719:
2712:
2677:
2673:
2663:
2628:
2624:
2576:
2572:
2562:
2527:
2523:
2513:
2488:
2484:
2477:
2452:
2448:
2442:
2417:
2414:Biochemistry
2413:
2407:
2374:
2370:
2364:
2329:
2326:Biochemistry
2325:
2315:
2290:
2286:
2280:
2235:
2231:
2193:
2190:Biochemistry
2189:
2183:
2142:
2138:
2074:
2070:
2060:
2019:
2015:
2009:
1984:
1980:
1974:
1962:. Retrieved
1958:
1949:
1940:
1931:
1922:
1913:
1833:
1829:
1816:
1806:
1800:
1798:
1781:
1772:ethanolamine
1765:
1756:-acyltaurine
1753:
1732:
1724:
1720:
1718:
1713:
1708:
1707:mutation in
1692:
1686:
1666:
1659:
1640:
1625:
1499:
1477:
1321:JNJ-42165279
1316:JNJ-42119779
1311:JNJ-40413269
1306:JNJ-28833155
1276:Bial-Portela
1266:flurbiprofen
1256:
1252:
1242:
1234:irreversible
1231:
1221:, including
1205:
1189:
1166:
1159:
1150:
1134:
1130:
1126:
1119:
1118:
1108:
1094:
1087:
1080:
1063:
1028:
1021:
1011:
1002:
985:
981:
980:
903:
882:
856:
835:
811:
792:
766:
747:
721:
702:
682:
677:
597:cytoskeleton
469:right kidney
403:right testis
353:
346:
312:115,875,123
299:115,824,342
73:External IDs
29:
6436:Active site
6345:: Nitriles/
6225:Barbiturase
6152:Biotinidase
6142:Glutaminase
6005:Precursors:
5957:Inhibitors:
5879:Inhibitors:
5854:Pristimerin
5796:Inhibitors:
5775:Activators:
5688:JNJ-1661010
5673:Biochanin A
5668:BIA 10-2474
5642:Inhibitors:
5543:Guineensine
5538:Cannabidiol
5510:Inhibitors:
5480:Transporter
5462:PSN-632,408
5457:PSN-375,963
5376:PSB-SB-1203
5371:PSB-SB-1202
5336:Cannabidiol
5329:Antagonists
5280:GSK-494581A
5197:Antagonists
5173:Cannabidiol
5091:Cannabidiol
5069:Antagonists
5060:Virodhamine
5015:PF-03550096
4935:GW-842,166X
4900:AZ-11713908
4793:Virodhamine
4733:Ibipinabant
4728:Hemopressin
4708:Cannabidiol
4696:Antagonists
4662:Monlunabant
4611:Pravadoline
4526:Epicatechin
4481:AZ-11713908
4436:AB-CHMINACA
3974:10576/44602
3821:(6): 1164.
3658:NCT01748695
3587:NCT00822744
2726:: 668–678.
2491:: 173–179.
1745:Wnt pathway
1632:proteolytic
1490:double bond
1430:(KDS-4103,
1377:PF-04862853
1332:Cannabidiol
1301:JNJ-1661010
1272:BIA 10-2474
1162:nociception
473:gallbladder
399:left testis
211:46,413,848
198:46,394,317
51:Identifiers
6708:Categories
6639:Isomerases
6613:Hydrolases
6480:Regulation
6263:Agmatinase
6180:Ceramidase
6111:Hydrolases
5708:LY-2183240
5703:Kaempferol
5618:modulators
5548:LY-2183240
5513:5'-DMH-CBD
5486:modulators
5432:AS-1269574
5427:AR-231,453
5417:Anandamide
5366:PSB-SB-487
5270:CID1792579
5265:CID1252842
5260:CID1011163
5168:Anandamide
5116:WIN 56,098
5111:WIN 54,461
5106:SR-144,528
4905:Cannabinol
4895:Anandamide
4778:Selonabant
4773:Rosonabant
4738:LY-320,135
4677:Taranabant
4672:Surinabant
4667:Rimonabant
4486:Cannabinol
4471:Anandamide
4403:(abridged,
4359:modulators
3391:21 January
3208:16 January
1908:, May 2017
1887:, May 2017
1864:References
1790:Regulation
1778:Structures
1701:Jo Cameron
1689:pseudogene
1683:Jo Cameron
1647:anandamide
1545:Chromosome
1452:VER-156084
1406:SSR-411298
1327:LY-2183240
1286:BMS-469908
1238:reversible
1177:anxiolytic
1145:, and the
1085:, such as
1060:Anandamide
1000:(AEA), an
998:anandamide
992:family of
391:C1 segment
357:(ortholog)
94:HomoloGene
6518:EC number
6356:Nitrilase
6035:receptor)
5678:Genistein
5275:CP 55,940
5040:Tedalinab
5020:S-444,823
4980:L-759,656
4975:L-759,633
4925:CP 55,940
4865:A-836,339
4860:A-834,735
4855:A-796,260
4763:PF-514273
4758:Otenabant
4748:NESS-0327
4718:Drinabant
4581:Menabitan
4571:L-759,633
4501:CP 55,940
4496:CP 47,497
4406:full list
4222:;
3923:1573-7780
2334:CiteSeerX
2322:Siuzdak G
2135:;
1955:"UniProt"
1768:substrate
1636:half-life
1436:carbamate
1347:MM-433593
1291:CAY-10402
1173:analgesic
1155:exogenous
1046:catabolic
1031:-terminal
1024:hydrolase
906:NP_034303
885:NP_001432
859:NM_010173
838:NM_001441
668:Orthologs
582:cytoplasm
453:CA3 field
102:GeneCards
6724:EC 3.5.1
6542:Kinetics
6466:Cofactor
6429:Activity
6258:Arginase
6055:See also
5809:JJKK 048
5799:ABX-1431
5568:SB-FI-26
5437:MBX-2982
5405:Agonists
5233:Agonists
5146:Agonists
5096:Honokiol
4990:Magnolol
4945:JTE 7-31
4920:CBS-0550
4823:Agonists
4682:TM-38837
4636:Yangonin
4606:Oleamide
4586:Nabilone
4536:Honokiol
4400:Agonists
4367:Receptor
4270:18753625
4201:23044255
4152:20694697
4109:29 March
4083:29 March
4045:30929760
3993:37222214
3984:10473560
3931:54717193
3888:27140937
3847:37372343
3838:10298391
3792:20525978
3751:10021942
3715:22209458
3643:19515560
3572:26408159
3531:17949010
3493:23108553
3444:16314570
3367:26713105
3318:21502526
3259:23512546
3189:(online)
3171:41218277
3163:26413912
3128:24135210
3087:33195822
3079:23488865
3044:21631410
3009:20370710
2974:20047159
2947:20544003
2898:19367506
2845:34361066
2794:23187822
2740:27456243
2704:24325918
2655:23333350
2603:25998048
2554:25207181
2505:24275607
2469:15362158
2434:16866345
2356:15533037
2307:11106785
2272:11470906
2210:10571985
2175:22656813
2167:12459591
1904:–
1883:–
1842:See also
1826:3.5.1.99
1733:FAAH-OUT
1729:intronic
1725:FAAH-OUT
1721:FAAH-OUT
1714:FAAH-OUT
1709:FAAH-OUT
1674:FAAH-OUT
1512:rs324420
1466:Vernalis
1462:V-158866
1456:Vernalis
1280:Portugal
1253:in vitro
1229:levels.
1103:oleamide
1038:esterase
1018:Function
954:Wikidata
647:Sources:
612:membrane
18:FAAH-OUT
6698:Biology
6652:Ligases
6422:Enzymes
6368:: Other
6200:Sirtuin
6040:ARN-272
6025:Others:
5912:LEI-106
5887:JZP-430
5882:JZP-169
5859:URB-602
5829:JZP-361
5824:JZL-195
5819:JZL-184
5768:URB-597
5753:TAK 21d
5728:PF-3845
5698:JZL-195
5598:WOBE492
5593:WOBE491
5588:WOBE490
5578:URB-597
5573:UCM-707
5533:Arvanil
5523:AM-1172
5452:Olvanil
5204:PSB-CB5
5101:JTE-907
5086:BML-190
5025:SER-601
5000:Nabitan
4970:JWH-133
4960:JWH-018
4955:JWH-015
4950:JWH-007
4890:AM-2232
4885:AM-1241
4880:AM-1235
4875:AM-1221
4870:AM-1172
4743:MK-9470
4703:AM-6545
4657:INV-202
4591:Nabitan
4561:JWH-073
4556:JWH-018
4551:JWH-015
4546:JWH-007
4476:Arvanil
4466:AM-2232
4461:AM-2201
4456:AM-1235
4451:AM-1221
4446:AM-1220
4441:AM-1172
4373:ligands
4261:2529035
4238:Bibcode
4192:3760509
4036:6676009
3484:3481531
3435:1295594
3358:4677372
3309:3088576
3286:Bibcode
3250:3639726
3194:Science
2938:2882713
2889:5531754
2836:8348051
2785:3588872
2695:4169112
2646:3662489
2594:4518073
2545:4115931
2399:7770779
2379:Bibcode
2371:Science
2240:Bibcode
2147:Bibcode
2139:Science
2111:9122178
2079:Bibcode
2052:4288981
2044:8900284
2024:Bibcode
2001:8373432
1964:18 July
1906:Ensembl
1885:Ensembl
1817:In the
1610:SNPedia
1574:Ensembl
1524:Name(s)
1412:ST-4068
1372:PF-3845
1342:MK-4409
1337:MK-3168
1296:JNJ-245
1262:ARN2508
1257:in vivo
1219:tissues
1042:amidase
994:enzymes
780:UniProt
735:Ensembl
674:Species
653:QuickGO
332:pattern
58:Aliases
6684:Portal
6626:Lyases
6366:3.5.99
6169:(ACY2)
6147:Urease
5998:Others
5948:ABHD12
5937:WWL-70
5932:UCM710
5844:MJN110
5834:KML 29
5814:JW 642
5778:PDP-EA
5763:UCM710
5758:TC-F 2
5733:PF-750
5658:AM-404
5650:AACOCF
5612:Enzyme
5583:VDM-11
5558:OMDM-2
5553:O-2093
5518:AM-404
5422:APD668
5396:GPR119
5361:O-1918
5356:ML-193
5351:ML-192
5346:ML-191
5305:O-1602
5300:ML-186
5295:ML-185
5290:ML-184
5255:AM-251
5245:2-ALPI
5209:O-1918
5188:O-1602
5178:NADGly
5081:AM-630
5035:UR-144
4995:MDA-19
4965:JWH-73
4940:HU-308
4768:PipISB
4753:O-2050
4652:AM-251
4626:UR-144
4601:O-1812
4566:Kavain
4541:HU-210
4310:(MeSH)
4268:
4258:
4199:
4189:
4150:
4140:
4043:
4033:
3991:
3981:
3929:
3921:
3886:
3845:
3835:
3790:
3749:
3713:
3681:
3641:
3570:
3560:
3529:
3491:
3481:
3442:
3432:
3365:
3355:
3316:
3306:
3257:
3247:
3169:
3161:
3126:
3085:
3077:
3042:
3007:
2972:
2945:
2935:
2896:
2886:
2843:
2833:
2792:
2782:
2738:
2702:
2692:
2653:
2643:
2601:
2591:
2552:
2542:
2503:
2467:
2432:
2397:
2354:
2336:
2305:
2270:
2260:
2208:
2173:
2165:
2109:
2099:
2050:
2042:
2016:Nature
1999:
1762:Assays
1655:Polish
1615:324420
1603:324420
1598:HapMap
1591:324420
1556:Region
1447:URB937
1442:URB694
1428:URB597
1423:URB524
1391:RN-450
1367:PF-750
1362:PF-622
1357:OL-135
1183:, and
1141:, the
1078:Other
1053:lipids
1049:enzyme
940:search
938:PubMed
813:O08914
794:O00519
690:Entrez
503:BioGPS
90:109609
82:602935
6578:Types
6343:3.5.5
6326:AICDA
6278:3.5.4
6245:3.5.3
6212:3.5.2
6124:3.5.1
5927:ML296
5922:ML295
5917:ML294
5907:KT203
5902:KT195
5897:KT185
5892:KT182
5870:ABHD6
5748:SA-57
5743:SA-47
5498:eCBTs
5224:GPR55
5163:AM251
5136:GPR18
5131:NAGly
4915:CB-13
4788:VCHSR
4491:CB-13
3953:Brain
3927:S2CID
3815:Genes
3167:S2CID
3083:S2CID
2263:55427
2171:S2CID
2102:20071
2048:S2CID
1835:FAAH2
1741:ACKR3
1586:dbSNP
1484:delta
1482:of a
1418:TK-25
1401:SA-73
1396:SA-47
1352:OL-92
1249:AM374
723:14073
683:Mouse
678:Human
649:Amigo
355:Mouse
348:Human
295:Start
230:Mouse
194:Start
127:Human
98:68184
6670:list
6663:EC7
6657:list
6650:EC6
6644:list
6637:EC5
6631:list
6624:EC4
6618:list
6611:EC3
6605:list
6598:EC2
6592:list
6585:EC1
6173:ACY3
6162:ACY1
6117:3.5)
6028:2-PG
6013:NAPE
5970:MAFP
5839:MAFP
5804:IDFP
5788:MAGL
5713:MAFP
5683:IDFP
5630:FAAH
5158:ACPA
5050:THCV
5005:NADA
4830:2-AG
4783:THCV
4596:NADA
4521:EGCG
4416:2-AG
4266:PMID
4219:2VYA
4197:PMID
4148:PMID
4138:ISBN
4111:2019
4085:2019
4041:PMID
3989:PMID
3919:ISSN
3884:PMID
3843:PMID
3809:FAAH
3788:PMID
3747:PMID
3711:PMID
3639:PMID
3568:PMID
3558:ISBN
3527:PMID
3489:PMID
3440:PMID
3393:2016
3363:PMID
3314:PMID
3255:PMID
3210:2016
3159:PMID
3124:PMID
3075:PMID
3040:PMID
3005:PMID
2970:PMID
2943:PMID
2894:PMID
2841:PMID
2790:PMID
2736:PMID
2700:PMID
2651:PMID
2599:PMID
2550:PMID
2501:PMID
2465:PMID
2430:PMID
2395:PMID
2352:PMID
2303:PMID
2268:PMID
2206:PMID
2163:PMID
2132:1MT5
2107:PMID
2040:PMID
1997:PMID
1966:2023
1832:and
1830:FAAH
1749:BDNF
1693:FAAH
1559:Exon
1538:FAAH
1533:Gene
1236:and
1223:skin
1151:FAAH
1135:FAAH
1120:FAAH
1107:The
1092:and
1040:and
1012:FAAH
1009:gene
986:FAAH
704:2166
338:Bgee
286:Band
247:Chr.
190:1p33
185:Band
144:Chr.
106:FAAH
78:OMIM
65:FAAH
42:FAAH
5849:NAM
4516:ECG
4511:DEA
4256:PMC
4246:doi
4234:105
4215:PDB
4187:PMC
4179:doi
4175:432
4130:doi
4031:PMC
4023:doi
4019:123
3979:PMC
3969:hdl
3961:doi
3957:146
3911:doi
3874:doi
3833:PMC
3823:doi
3778:doi
3774:105
3739:doi
3703:doi
3631:doi
3550:doi
3519:doi
3479:PMC
3471:doi
3467:367
3430:PMC
3420:doi
3416:102
3353:PMC
3345:doi
3304:PMC
3294:doi
3282:108
3245:PMC
3237:doi
3199:doi
3151:doi
3114:doi
3067:doi
3032:doi
2997:doi
2933:PMC
2925:doi
2884:PMC
2876:doi
2831:PMC
2821:doi
2780:PMC
2770:doi
2728:doi
2724:111
2690:PMC
2682:doi
2641:PMC
2633:doi
2629:138
2589:PMC
2581:doi
2577:354
2540:PMC
2532:doi
2493:doi
2457:doi
2422:doi
2387:doi
2375:268
2344:doi
2295:doi
2291:108
2258:PMC
2248:doi
2198:doi
2155:doi
2143:298
2128:PDB
2097:PMC
2087:doi
2032:doi
2020:384
1989:doi
1784:PDB
1487:cis
1215:CB2
1213:or
1211:CB1
511:n/a
308:End
207:End
110:OMA
86:MGI
6710::
6115:EC
4808:CB
4385:CB
4286:.
4264:.
4254:.
4244:.
4232:.
4228:.
4217::
4195:.
4185:.
4173:.
4169:.
4146:.
4136:.
4102:.
4076:.
4055:.
4039:.
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3967:.
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3925:.
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3882:.
3870:27
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314:bp
301:bp
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200:bp
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