1163:
provisional matrix that interacted with fibrin and fibronectin (Fn) which has improved the cell adhesion activity of Fn. A provisional matrix is forms of extravasated blood after the wounding, which compose of the wound fluid, fibrin and Fn. In the provisional matrix, the Fn perform as an adhesion and migration structure to provide support all around the ECM for fibroblasts and circulation-derived cells, while in tissues, Fn perform as an activated and collected into the Fn matrix (a fibrillar structure) that discovered during both development of embryonic and wound healing. Dermatopontin has been found in the provisional matrix as well as in the wound fluid, and it has demonstrated that dermatopontin promoted Fn fibril formation that biologically functions in the dermal wound healing, and the presence of dermatopontin has enhanced the Fn interaction with fibrin as well as the enhancement of cell adhesion, which indicated the morphological changed of the cells that has been adhered to the complex. Dermatopontin determined to be found in the interaction sites of Fn on III_13 and III_14 and cryptic site of III_1, which all involved in formation of Fn fibrils, and the inhibition of dermatopontin were considering to be between III_(2-3) and III_(12-14) because dermatopontin was not enhanced the interaction between III_(1-5) and III_(1-2), which could be the domains unfold as the disruption of the other interdomain interactions. In this case, dermatopontin indicated as domain unfolding of a Fn molecule due to the binding site for anastellin (the only known protein that induce superfibronectin formation) on Fn is located between III_(2-3) and III_(12-14) inside the interaction site, which is the important binding site for the Fn fibril formation. Therefore, dermatopontin is protein within the ECM that could activate Fn and induce Fn fibril formation, which could help in wound healing due to its accumulation in the wound whether from the ECM's surrounded or from the serum.
242:
219:
141:
116:
493:
507:
500:
248:
147:
1032:(ECM), which is a gel-like fluid space outside of a cell that consists of collagen fibers, elastin fibers, glycoproteins, and proteoglycans (1). The components of the ECM are connected to proteins embedded in the plasma membrane of cells. These membrane proteins perform many functions, including transporting materials, serving as enzymes for chemical reactions, transmitting cell signals, and intercellular junction (1).
1622:
Lieveld M, Bodson E, De Boeck G, Nouman B, Cleton-Jansen AM, Korsching E, Benassi MS, Picci P, Sys G, Poffyn B, Athanasou NA, Hogendoorn PC, Forsyth RG (December 2014). "Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican
1092:
protein with possible functions in cell-matrix interactions and matrix assembly. The extracellular matrix (ECM) is known as a non-cellular component that is found in all organs and tissues. The ECM provides not only a physical scaffolding for individual cells, but also biomechanical communication
1162:
Cell adhesion is the effect of the cell behavior due to the function of the dermatopontin. Even though, cell adhesion activity of dermatopontin isn't strong for a certain fibroblasts and neurogenic cells, but it might have various roles in wound healings because dermatopontin has been found in a
1073:
binding and accelerates collagen fibril formation that determines the size and arrangement of collagen fibrils within the extracellular matrix (2). Other functions of dermatopontin include stabilizing collagen fibrils against low temperature dissociation, inhibiting cell proliferation, enhancing
1035:
Dermatopontins are expressed primarily in fibroblasts, heart tissue, skeletal muscle, brain and pancreas. They occur less frequently in lungs and kidneys, and much less frequently in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in
1109:. Since DPT is a proteoglycan binding protein, this helps in the adhesion between fibroblasts and keratinocytes. Dermatopontin (DPT) has a high expression of dermis and is part of the non-collagenous matrix. DPT also has an important role in activating
1205:
There is also a relationship between CCW (chronic cutaneous wound) and the DPT gene. The healing of CCW can be inhibited through the destruction of some matrix proteins, such as DPT and low levels of DTP expression slows the rate of healing.
1676:
Krishnaswamy VR, Manikandan M, Munirajan AK, Vijayaraghavan D, Korrapati PS (December 2014). "Expression and integrity of dermatopontin in chronic cutaneous wounds: a crucial factor in impaired wound healing".
255:
154:
1308:
Superti-Furga A, Rocchi M, Schäfer BW, Gitzelmann R (August 1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)".
1213:) as well. It was shown that OSCC cells had a suppressed response to DPT. DPT expression had an inverse relationship with cellular adhesion, and a direct relationship with its invasiveness.
981:(ECM) estimated to comprise 12 mg/kg of wet dermis weight. To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions. In
1832:"Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen"
1128:
and the many different growth factors that are located within the extracellular matrix. DPT was found able to aid in the migration of keratinocytes, but failed in the ability to induce
1062:
that holds membranes of adjacent cells together (2). The components of the ECM are connected to proteins embedded in the plasma membrane, which in turn are connected to the internal
1801:
Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles".
1132:. The keratinocytes are epidermal cells that help with the production of keratin, which is a fibrous protein that can be found in hair, feathers, and hooves.
700:
681:
77:
1290:
1272:
1008:). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in
900:
907:
1135:
In the skin, DPT is found in the collagen fibers and also in the cytoplasm of cultured fibroblasts.” DPT has also been found in the
1039:
In the skin, DPT is found in the collagen fibers and also in the cytoplasm of cultured fibroblasts.” DPT has also been found in the
1348:
1906:"Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated and widely distributed protein of the extracellular matrix"
1954:
1255:
1949:
1234:
1124:
is also an important part of healing wounds. Both DPT and re-epithelialization depend on the migration of the epidermal
1171:
Dermatopontin plays a key role in interactions of the cell matrix and its assembly that can in turn induce cellular
241:
1259:
1238:
218:
1530:
Kato A, Okamoto O, Ishikawa K, Sumiyoshi H, Matsuo N, Yoshioka H, Nomizu M, Shimada T, Fujiwara S (April 2011).
745:
1532:"Dermatopontin interacts with fibronectin, promotes fibronectin fibril formation, and enhances cell adhesion"
1720:
Yamatoji M, Kasamatsu A, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K (June 2012).
726:
140:
115:
57:
1433:
Okamoto O, Fujiwara S (2006). "Dermatopontin, a novel player in the biology of the extracellular matrix".
1367:"Role of dermatopontin in re-epithelialization: implications on keratinocyte migration and proliferation"
254:
153:
1583:"Effects of Dermatopontin gene silencing on apoptosis and proliferation of osteosarcoma MG‑63 cells"
247:
146:
44:
1867:"Dermatopontin interacts with transforming growth factor beta and enhances its biological activity"
1199:
1098:
65:
1210:
985:, the primary function of dermatopontin is a structural component of the ECM (interaction with
883:
862:
836:
815:
1129:
1085:
Dermatopontin itself is a noncollagenous ECM protein but it facilitates collagen binding (2).
1768:"Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor"
1378:
1089:
1029:
978:
129:
8:
1766:
Pochampally RR, Ylostalo J, Penfornis P, Matz RR, Smith JR, Prockop DJ (September 2007).
1050:
The protein is found in various tissues and many of its tyrosine residues are sulphated.
1005:
85:
1382:
1887:
1866:
1702:
1658:
1558:
1531:
1502:
1477:
1458:
1399:
1366:
89:
615:
610:
605:
589:
584:
579:
574:
569:
553:
548:
1927:
1922:
1905:
1892:
1853:
1848:
1831:
1818:
1789:
1743:
1694:
1650:
1604:
1563:
1507:
1450:
1404:
1325:
1121:
37:
1706:
1662:
1462:
69:
1917:
1882:
1874:
1843:
1810:
1779:
1733:
1686:
1640:
1632:
1594:
1553:
1543:
1497:
1489:
1442:
1394:
1386:
1317:
1017:
334:
265:
209:
164:
1140:
1044:
993:
309:
93:
1878:
1295:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1277:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1066:
of the cell. These connections also facilitate cell-to-cell communication (1).
410:
1690:
1636:
1446:
1943:
1675:
1581:
Xi LC, Ji YX, Yin D, Zhao ZX, Huang SC, Yu SL, Liu BY, Li HY (January 2018).
1114:
1106:
1094:
1059:
997:
535:
1548:
492:
470:
348:
1857:
1822:
1793:
1747:
1698:
1654:
1608:
1567:
1511:
1454:
1408:
1321:
1176:
1125:
1063:
327:
106:
1931:
1896:
1722:"Dermatopontin: a potential predictor for metastasis of human oral cancer"
1599:
1582:
1329:
1105:. One of the major roles of Dermatopontin includes its ability to promote
1078:
activity, and possibly serving as a communication link between the dermal
947:
506:
499:
1183:, silencing the DPT gene decreased the proliferation of the MG-63 cells.
1102:
790:
771:
1784:
1767:
942:
1814:
1645:
1493:
1110:
1079:
982:
226:
123:
73:
1738:
1721:
1390:
1195:
1180:
1172:
1009:
645:
293:
280:
192:
179:
81:
1800:
1307:
1147:
1070:
1020:, cell-cell aggregation, and expression during parasite infection.
1013:
990:
931:
1001:
1904:
Forbes EG, Cronshaw AD, MacBeath JR, Hulmes DJ (September 1994).
1191:
1187:
1151:
986:
967:
757:
712:
630:
626:
1765:
61:
1136:
1040:
915:
667:
515:
1075:
1903:
1529:
1719:
1621:
1016:. In invertebrate, dermatopontin homologue plays a role in
974:
977:. Dermatopontin is a 22-kDa protein of the noncollagenous
317:
1865:
Okamoto O, Fujiwara S, Abe M, Sato Y (February 1999).
1864:
1146:
Dermatopontin is postulated to modify the behavior of
1364:
482:
1829:
1082:
cell surface and its extracellular environment (3).
611:
negative regulation of cell population proliferation
1475:
1360:
1358:
1023:
1251:
1249:
1247:
1230:
1228:
1226:
1476:Frantz C, Stewart KM, Weaver VM (December 2010).
264:
163:
1941:
1355:
1069:Dermatopontin mediates adhesion by cell surface
1432:
1365:Krishnaswamy VR, Korrapati PS (December 2014).
1244:
1223:
16:Protein-coding gene in the species Homo sapiens
1428:
1426:
1424:
1422:
1420:
1418:
1256:GRCm38: Ensembl release 89: ENSMUSG00000026574
1525:
1523:
1521:
1830:Kuroda K, Okamoto O, Shinkai H (May 1999).
1580:
1415:
1235:GRCh38: Ensembl release 89: ENSG00000143196
549:extracellular matrix structural constituent
1301:
1113:(TGF-β1). TGF-β1 has an important role in
1921:
1886:
1847:
1783:
1737:
1644:
1598:
1557:
1547:
1518:
1501:
1398:
1836:The Journal of Investigative Dermatology
1343:
1341:
1339:
590:collagen-containing extracellular matrix
1209:DPT is also a biomarker for OSCC (oral
1942:
1478:"The extracellular matrix at a glance"
1336:
269:
230:
225:
168:
127:
122:
1772:Journal of Bone and Mineral Research
1093:between cells that is required for
1058:Dermatopontin is a component of the
1536:The Journal of Biological Chemistry
964:tyrosine-rich acidic matrix protein
13:
1758:
1623:associated with lung metastasis".
1028:Dermatopontin is expressed in the
14:
1966:
1111:transforming growth factor beta 1
970:that in humans is encoded by the
1849:10.1046/j.1523-1747.1999.00563.x
1349:"Entrez Gene: DPT dermatopontin"
1157:
1024:Cellular and tissue distribution
505:
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1726:International Journal of Cancer
1713:
1669:
1615:
1574:
1166:
1469:
1283:
1265:
516:More reference expression data
471:More reference expression data
1:
1955:Extracellular matrix proteins
1803:Journal of Biomedical Science
1216:
1036:normal skin fibroblasts (3).
363:muscle layer of sigmoid colon
238:
137:
1923:10.1016/0014-5793(94)00907-4
616:collagen fibril organization
7:
1950:Genes on human chromosome 1
1873:. 337 ( Pt 3) (3): 537–41.
1053:
433:subcutaneous adipose tissue
375:subcutaneous adipose tissue
10:
1971:
1587:Molecular Medicine Reports
1435:Connective Tissue Research
1879:10.1042/0264-6021:3370537
1691:10.1007/s00441-014-2000-z
1637:10.1007/s00428-014-1666-7
1447:10.1080/03008200600846564
1291:"Mouse PubMed Reference:"
1273:"Human PubMed Reference:"
1150:through interaction with
946:
941:
937:
930:
914:
908:Chr 1: 164.62 – 164.65 Mb
895:
880:
876:
859:
855:
848:
833:
829:
812:
808:
801:
788:
784:
769:
765:
756:
743:
739:
724:
720:
711:
698:
694:
679:
675:
666:
651:
644:
640:
624:
534:
530:
513:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1679:Cell and Tissue Research
1200:giant-cell tumor of bone
901:Chr 1: 168.7 – 168.73 Mb
1871:The Biochemical Journal
1549:10.1074/jbc.M110.179762
1482:Journal of Cell Science
1211:squamous cell carcinoma
1322:10.1006/geno.1993.1348
1130:cellular proliferation
1060:intercellular junction
48:, TRAMP, dermatopontin
1600:10.3892/mmr.2017.7866
580:extracellular exosome
1090:extracellular matrix
1088:Dermatopontin is an
1030:extracellular matrix
989:and modification of
979:extracellular matrix
575:extracellular region
570:extracellular matrix
457:white adipose tissue
359:smooth muscle tissue
232:Chromosome 1 (mouse)
130:Chromosome 1 (human)
1785:10.1359/jbmr.070605
1488:(Pt 24): 4195–200.
1383:2014NatSR...4E7385K
1139:, specifically the
1043:, specifically the
1006:cellular quiescence
585:extracellular space
367:epithelium of colon
1815:10.1007/BF02256581
1494:10.1242/jcs.023820
1371:Scientific Reports
746:ENSMUSG00000026574
599:Biological process
563:Cellular component
542:Molecular function
437:intercostal muscle
1739:10.1002/ijc.26328
1391:10.1038/srep07385
1122:epithelialization
957:
956:
953:
952:
926:
925:
891:
890:
870:
869:
844:
843:
823:
822:
797:
796:
778:
777:
752:
751:
733:
732:
707:
706:
688:
687:
636:
635:
526:
525:
522:
521:
477:
476:
464:
463:
402:
401:
383:left uterine tube
379:lactiferous gland
300:
299:
199:
198:
1962:
1935:
1925:
1900:
1890:
1861:
1851:
1826:
1797:
1787:
1752:
1751:
1741:
1717:
1711:
1710:
1673:
1667:
1666:
1648:
1619:
1613:
1612:
1602:
1578:
1572:
1571:
1561:
1551:
1527:
1516:
1515:
1505:
1473:
1467:
1466:
1430:
1413:
1412:
1402:
1362:
1353:
1352:
1345:
1334:
1333:
1305:
1299:
1298:
1287:
1281:
1280:
1269:
1263:
1253:
1242:
1232:
1186:DPT, along with
1018:hemagglutination
1000:, modulation of
939:
938:
910:
903:
886:
874:
873:
865:
853:
852:
849:RefSeq (protein)
839:
827:
826:
818:
806:
805:
782:
781:
763:
762:
737:
736:
718:
717:
692:
691:
673:
672:
642:
641:
532:
531:
518:
509:
502:
495:
488:
487:
473:
421:semi-lunar valve
413:
411:Top expressed in
406:
405:
351:
349:Top expressed in
344:
343:
323:
322:
306:
305:
296:
283:
272:
257:
250:
244:
233:
221:
205:
204:
195:
182:
171:
156:
149:
143:
132:
118:
102:
101:
96:
47:
40:
19:
18:
1970:
1969:
1965:
1964:
1963:
1961:
1960:
1959:
1940:
1939:
1938:
1761:
1759:Further reading
1756:
1755:
1732:(12): 2903–11.
1718:
1714:
1674:
1670:
1625:Virchows Archiv
1620:
1616:
1579:
1575:
1542:(17): 14861–9.
1528:
1519:
1474:
1470:
1431:
1416:
1363:
1356:
1347:
1346:
1337:
1306:
1302:
1289:
1288:
1284:
1271:
1270:
1266:
1254:
1245:
1233:
1224:
1219:
1169:
1160:
1099:differentiation
1056:
1026:
994:fibrillogenesis
948:View/Edit Mouse
943:View/Edit Human
906:
899:
896:Location (UCSC)
882:
861:
835:
814:
727:ENSG00000143196
620:
594:
558:
554:protein binding
514:
504:
503:
497:
496:
469:
460:
455:
453:ascending aorta
451:
447:
443:
441:skin of abdomen
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
94:DPT - orthologs
56:
43:
36:
17:
12:
11:
5:
1968:
1958:
1957:
1952:
1937:
1936:
1901:
1862:
1827:
1798:
1778:(9): 1338–49.
1762:
1760:
1757:
1754:
1753:
1712:
1668:
1614:
1593:(1): 422–427.
1573:
1517:
1468:
1414:
1354:
1335:
1300:
1282:
1264:
1243:
1221:
1220:
1218:
1215:
1168:
1165:
1159:
1156:
1055:
1052:
1025:
1022:
962:also known as
955:
954:
951:
950:
945:
935:
934:
928:
927:
924:
923:
921:
919:
912:
911:
904:
897:
893:
892:
889:
888:
878:
877:
871:
868:
867:
857:
856:
850:
846:
845:
842:
841:
831:
830:
824:
821:
820:
810:
809:
803:
799:
798:
795:
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786:
785:
779:
776:
775:
767:
766:
760:
754:
753:
750:
749:
741:
740:
734:
731:
730:
722:
721:
715:
709:
708:
705:
704:
696:
695:
689:
686:
685:
677:
676:
670:
664:
663:
658:
653:
649:
648:
638:
637:
634:
633:
622:
621:
619:
618:
613:
608:
602:
600:
596:
595:
593:
592:
587:
582:
577:
572:
566:
564:
560:
559:
557:
556:
551:
545:
543:
539:
538:
528:
527:
524:
523:
520:
519:
511:
510:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
391:gastric mucosa
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
1967:
1956:
1953:
1951:
1948:
1947:
1945:
1933:
1929:
1924:
1919:
1915:
1911:
1907:
1902:
1898:
1894:
1889:
1884:
1880:
1876:
1872:
1868:
1863:
1859:
1855:
1850:
1845:
1842:(5): 706–10.
1841:
1837:
1833:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1799:
1795:
1791:
1786:
1781:
1777:
1773:
1769:
1764:
1763:
1749:
1745:
1740:
1735:
1731:
1727:
1723:
1716:
1708:
1704:
1700:
1696:
1692:
1688:
1685:(3): 833–41.
1684:
1680:
1672:
1664:
1660:
1656:
1652:
1647:
1642:
1638:
1634:
1631:(6): 703–13.
1630:
1626:
1618:
1610:
1606:
1601:
1596:
1592:
1588:
1584:
1577:
1569:
1565:
1560:
1555:
1550:
1545:
1541:
1537:
1533:
1526:
1524:
1522:
1513:
1509:
1504:
1499:
1495:
1491:
1487:
1483:
1479:
1472:
1464:
1460:
1456:
1452:
1448:
1444:
1441:(4): 177–89.
1440:
1436:
1429:
1427:
1425:
1423:
1421:
1419:
1410:
1406:
1401:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1361:
1359:
1350:
1344:
1342:
1340:
1331:
1327:
1323:
1319:
1315:
1311:
1304:
1296:
1292:
1286:
1278:
1274:
1268:
1261:
1257:
1252:
1250:
1248:
1240:
1236:
1231:
1229:
1227:
1222:
1214:
1212:
1207:
1203:
1201:
1197:
1193:
1189:
1184:
1182:
1178:
1174:
1164:
1158:Cell adhesion
1155:
1153:
1149:
1144:
1142:
1138:
1133:
1131:
1127:
1126:keratinocytes
1123:
1118:
1116:
1115:wound healing
1112:
1108:
1107:cell adhesion
1104:
1100:
1096:
1095:morphogenesis
1091:
1086:
1083:
1081:
1077:
1072:
1067:
1065:
1061:
1051:
1048:
1046:
1042:
1037:
1033:
1031:
1021:
1019:
1015:
1011:
1007:
1004:activity and
1003:
999:
998:cell adhesion
995:
992:
988:
984:
980:
976:
973:
969:
966:(TRAMP) is a
965:
961:
960:Dermatopontin
949:
944:
940:
936:
933:
929:
922:
920:
917:
913:
909:
905:
902:
898:
894:
887:
885:
879:
875:
872:
866:
864:
858:
854:
851:
847:
840:
838:
832:
828:
825:
819:
817:
811:
807:
804:
802:RefSeq (mRNA)
800:
793:
792:
787:
783:
780:
774:
773:
768:
764:
761:
759:
755:
748:
747:
742:
738:
735:
729:
728:
723:
719:
716:
714:
710:
703:
702:
697:
693:
690:
684:
683:
678:
674:
671:
669:
665:
662:
659:
657:
654:
650:
647:
643:
639:
632:
628:
623:
617:
614:
612:
609:
607:
606:cell adhesion
604:
603:
601:
598:
597:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
567:
565:
562:
561:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
371:right auricle
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:1|1 H2.2
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1916:(3): 433–6.
1913:
1910:FEBS Letters
1909:
1870:
1839:
1835:
1809:(1): 82–96.
1806:
1802:
1775:
1771:
1729:
1725:
1715:
1682:
1678:
1671:
1628:
1624:
1617:
1590:
1586:
1576:
1539:
1535:
1485:
1481:
1471:
1438:
1434:
1374:
1370:
1316:(2): 463–7.
1313:
1309:
1303:
1294:
1285:
1276:
1267:
1208:
1204:
1185:
1177:osteosarcoma
1170:
1167:Applications
1161:
1145:
1134:
1119:
1087:
1084:
1068:
1064:cytoskeleton
1057:
1049:
1038:
1034:
1027:
971:
963:
959:
958:
881:
860:
834:
813:
789:
770:
744:
725:
699:
680:
660:
655:
445:carotid body
425:aortic valve
333:
326:
292:164,651,835
279:164,624,213
191:168,729,206
178:168,695,468
53:External IDs
1646:1887/105336
1103:homeostasis
983:vertebrates
387:gallbladder
31:Identifiers
1944:Categories
1262:, May 2017
1241:, May 2017
1217:References
1080:fibroblast
337:(ortholog)
74:HomoloGene
1196:biomarker
1181:cell line
1175:. In the
1173:apoptosis
1010:leiomyoma
884:NP_062733
863:NP_001928
837:NM_019759
816:NM_001937
646:Orthologs
82:GeneCards
1858:10233760
1823:11810028
1794:17547532
1748:21796630
1707:16355532
1699:25260909
1663:24625787
1655:25304290
1609:29115446
1568:21398523
1512:21123617
1463:23944137
1455:16987749
1409:25486882
1377:: 7385.
1310:Genomics
1258:–
1237:–
1202:(GCTB).
1148:TGF beta
1071:integrin
1054:Function
1014:fibrosis
991:collagen
932:Wikidata
625:Sources:
1932:8082810
1897:9895299
1888:1220007
1559:3083196
1503:2995612
1400:4260223
1379:Bibcode
1330:8104875
1260:Ensembl
1239:Ensembl
1194:, is a
1192:decorin
1188:lumican
1152:decorin
987:decorin
968:protein
758:UniProt
713:Ensembl
652:Species
631:QuickGO
312:pattern
70:1928392
38:Aliases
1930:
1895:
1885:
1856:
1821:
1792:
1746:
1705:
1697:
1661:
1653:
1607:
1566:
1556:
1510:
1500:
1461:
1453:
1407:
1397:
1328:
1179:MG-63
1141:stroma
1137:cornea
1045:stroma
1041:cornea
918:search
916:PubMed
791:Q9QZZ6
772:Q07507
668:Entrez
483:BioGPS
429:cervix
395:fundus
170:1q24.2
62:125597
1703:S2CID
1659:S2CID
1459:S2CID
1076:TGFB1
1002:TGF-β
701:56429
661:Mouse
656:Human
627:Amigo
449:ankle
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
1928:PMID
1893:PMID
1854:PMID
1819:PMID
1790:PMID
1744:PMID
1695:PMID
1651:PMID
1605:PMID
1564:PMID
1508:PMID
1451:PMID
1405:PMID
1326:PMID
1198:for
1190:and
1101:and
1012:and
975:gene
682:1805
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:1458
58:OMIM
1918:doi
1914:351
1883:PMC
1875:doi
1844:doi
1840:112
1811:doi
1780:doi
1734:doi
1730:130
1687:doi
1683:358
1641:hdl
1633:doi
1629:465
1595:doi
1554:PMC
1544:doi
1540:286
1498:PMC
1490:doi
1486:123
1443:doi
1395:PMC
1387:doi
1318:doi
1120:Re-
996:),
972:DPT
288:End
187:End
90:OMA
86:DPT
66:MGI
45:DPT
22:DPT
1946::
1926:.
1912:.
1908:.
1891:.
1881:.
1869:.
1852:.
1838:.
1834:.
1817:.
1805:.
1788:.
1776:22
1774:.
1770:.
1742:.
1728:.
1724:.
1701:.
1693:.
1681:.
1657:.
1649:.
1639:.
1627:.
1603:.
1591:17
1589:.
1585:.
1562:.
1552:.
1538:.
1534:.
1520:^
1506:.
1496:.
1484:.
1480:.
1457:.
1449:.
1439:47
1437:.
1417:^
1403:.
1393:.
1385:.
1373:.
1369:.
1357:^
1338:^
1324:.
1314:17
1312:.
1293:.
1275:.
1246:^
1225:^
1154:.
1143:.
1117:.
1097:,
1047:.
629:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1934:.
1920::
1899:.
1877::
1860:.
1846::
1825:.
1813::
1807:9
1796:.
1782::
1750:.
1736::
1709:.
1689::
1665:.
1643::
1635::
1611:.
1597::
1570:.
1546::
1514:.
1492::
1465:.
1445::
1411:.
1389::
1381::
1375:4
1351:.
1332:.
1320::
1297:.
1279:.
212:)
109:)
92::
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