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monoamine oxidase inhibitors such as nardil or parnate would be indicated, but lacking the dangers associated with that class of medication, as maois are extremely toxic in cases of overdose or deliberate or accidental ingestion of tyramine. This combination is regarded as extremely effective by patients and practitioners alike, and retains efficacy over time when used as directed, but both drugs do carry risks of abuse and dependency. Typically the CNS stimulant within these older combination drugs was
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of the CNS stimulant without simultaneously reducing its therapeutic benefits. Some psychiatrists will attempt to duplicate this effect, albeit only partially, using stimulants in conjunction with benzodiazepines such as clonazepam in patients with certain forms of refractory depression where
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of
Desbutal often involved physical separation of these two halves by sawing with a razor or fingernails, followed by the consumption of each active ingredient independently rather than concurrently. Typically abusers would ingest the blue half containing methamphetamine for stimulation and
196:
of tablets that were manufactured included 5 mg, 10 mg, and 15 mg of methamphetamine hydrochloride with 30 mg, 60 mg, and 90 mg of pentobarbital sodium, respectively.
434:(Preludin) was also marketed albeit less frequently. Typically the CNS depressant within these combination drugs was a single barbiturate salt, especially pentobarbital sodium and
382:
by approximately 90% throughout the prior two years, these combination drugs had rapidly grown in popularity throughout the two preceding decades. Many
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profile. Each tablet featured a yellow half which contained an immediate-release formulation of pentobarbital sodium, and a blue half which contained a
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had become established by researchers in 1955, they also emphasized that the accurate correlation of these factors is complicated by the presence of
398:, and at the time of the 1973 recall, the estimated annual distribution of these pills was equivalent to 480 million dosage units of
371:
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visibly partitioned between the two faces of the tablet to control their rates of dissolution and achieve a more preferable
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were also sometimes used. Some less common combination drug formulations included a CNS stimulant combined with multiple
89:
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61:
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306:. While a quantitative relationship between the blood levels of barbiturate derivatives and the depression of the
302:(Methedrine) in dosages sometimes exceeding 250 mg over the first 24-hour period of being admitted into an
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478:). Other formulations utilized amphetamines, barbiturates, and meprobamate for their ability to
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The medical justification for these combination drugs was that the CNS stimulant elevates
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for miscellaneous ailments. It had a high abuse potential and is no longer manufactured.
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amphetamines based on the FDA's contention that these products have such a great drug
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517:, an experimental drug containing methamphetamine, cocaine & oxycodone.
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formulation of methamphetamine hydrochloride (Desoxyn
Gradumet). The three
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and suppresses appetite, while the CNS depressant mitigates many of the
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of pentobarbital sodium is reached significantly sooner than the oral LD
523:, which is the same concept but using opioids instead of a barbiturate.
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505:, a single molecule with a similar effect (due to metabolites).
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Desbutal was designed as round biphasic tablets, with the two
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430:, or methamphetamine as various single or mixed salts, and
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Desbutal is no longer manufactured since withdrawal of its
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administration of multiple different drugs, since no
49:. Unsourced material may be challenged and removed.
358:. The recall also included all existing stocks of
244:of methamphetamine hydrochloride when consumed as
225:typically becomes life-threatening as a result of
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394:by continuously developing new combinations and
372:Bureau of Narcotics and Dangerous Drugs (BNDD)
152:as well as a medication for the treatment of
144:combined within the same pill. Desbutal was
168:, although it was commonly also prescribed
485:by combining them with analgesics such as
248:with the mass ratio present in Desbutal.
109:Learn how and when to remove this message
229:from pentobarbital poisoning, since the
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314:to the drug, intercurrent disease and
374:had already reduced the amphetamine
209:for counteracting stimulant-induced
47:adding citations to reliable sources
18:
580:Nextbio molecular image of Desbutal
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340:Food and Drug Administration (FDA)
14:
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256:which was treated with immediate
376:aggregate production quota (APQ)
282:were clinically available as an
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34:needs additional citations for
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472:first generation antihistamine
464:first generation antipsychotic
450:(Quaalude), a non-barbiturate
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1:
605:Combination psychiatric drugs
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130:methamphetamine hydrochloride
384:pharmaceutical manufacturers
380:pharmaceutical manufacturers
308:central nervous system (CNS)
213:whenever sleep was desired.
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432:phenmetrazine hydrochloride
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16:Brand name combination drug
10:
621:
552:Law Enforcement Technology
448:methaqualone hydrochloride
342:in 1973 as part of a mass
366:that they cannot be used
320:concurrent administration
304:intensive care unit (ICU)
132:(Desoxyn) and 30 mg
124:was a brand name drug by
595:Substituted amphetamines
548:""Speedballs" in a can"
300:methamphetamine sulfate
138:substituted amphetamine
262:mechanical ventilation
234:median lethal dose (LD
566:– via ProQuest.
128:containing 5 mg
402:10 mg tablets.
280:receptor antagonists
250:Barbiturate overdose
134:pentobarbital sodium
43:improve this article
470:was popular), or a
438:(Amytal), although
396:dosage formulations
264:, and intermittent
546:Kanable, Rebecca.
444:minor tranquilizer
436:sodium amobarbital
336:marketing approval
324:noxious substances
182:active ingredients
428:dextroamphetamine
348:combination drugs
318:, as well as the
254:medical emergency
190:sustained-release
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298:(Megimide), and
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136:(Nembutal); a
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99:February 2024
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54:Find sources:
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32:This article
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26:
21:
20:
600:Barbiturates
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551:
541:
409:
406:Medical uses
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292:amiphenazole
277:binding site
275:barbiturate
246:dosage units
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176:Dosage forms
162:parkinsonism
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41:Please help
36:verification
33:
440:meprobamate
424:amphetamine
330:Regulations
266:intravenous
221:A Desbutal
203:wakefulness
142:barbiturate
589:Categories
534:References
503:Amfecloral
487:phenacetin
480:potentiate
476:Obocell-TF
360:parenteral
288:picrotoxin
166:alcoholism
158:narcolepsy
69:newspapers
58:"Desbutal"
564:229774539
521:Speedball
483:analgesia
388:competing
322:of other
312:tolerance
296:bemegride
273:selective
170:off-label
560:ProQuest
497:See also
468:Eskatrol
460:minerals
456:vitamins
452:sedative
316:senility
284:antidote
223:overdose
217:Overdose
211:insomnia
207:hypnotic
146:marketed
122:Desbutal
509:Dexamyl
491:aspirin
421:racemic
400:Obetrol
338:by the
194:dosages
154:obesity
83:scholar
562:
527:Tuinal
446:, and
368:safely
344:recall
164:, and
148:as an
140:and a
126:Abbott
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558:(6).
269:bolus
252:is a
198:Abuse
90:JSTOR
76:books
515:D-IX
489:and
462:, a
458:and
412:mood
390:for
378:for
231:oral
62:news
45:by
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