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Alanine transaminase

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used ALT testing as part of the battery of tests to ensure the safety of its blood supply by deferring donors with elevated ALT levels. The intent was to identify donors potentially infected with hepatitis C because no specific test for that disease was available at the time. Prior to July 1992,
3699: 3694: 548:, the Red Cross changed the ALT policy. As of July 2003, donors previously disqualified for elevated ALT levels and no other reason may be reinstated as donors when they contact the donor-counseling department of their regional Red Cross organization. 516:. Also, myopathy-related elevations in ALT should be suspected when the aspartate transaminase (AST) is greater than ALT; the possibility of muscle disease causing elevations in liver tests can be further explored by measuring muscle enzymes, including 551:
In 2000, the American Association for Clinical Chemistry determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. The term transaminase is outdated and no longer used in liver disease.
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deficiency. However, elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and they can also increase in response to strenuous physical exercise.
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Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC (July 2006). "Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial".
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Aminotransferase clearance is carried out within the liver by sinusoidal cells. The half-life in the circulation is about 47 hours for ALT, about 17 hours for total AST and, on average, 87 hours for mitochondrial
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When elevated ALT levels are found in the blood, the possible underlying causes can be further narrowed down by measuring other enzymes. For example, elevated ALT levels due to
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Vespasiani-Gentilucci, Umberto; De Vincentis, Antonio; Ferrucci, Luigi; Bandinelli, Stefania; Incalzi, Raffaele Antonelli; Picardi, Antonio (17 June 2017).
4062: 2311: 2267: 1782: 663: 4276: 1031:"Effects of Prescription Omega-3-Acid Ethyl Esters on Non—High-Density Lipoprotein Cholesterol When Coadministered With Escalating Doses of Atorvastatin" 4102: 3862: 3163: 887:"Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data" 3284: 4280: 4272: 3936: 769:"Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity" 3887: 2587: 1872: 540:
widespread blood donation testing in the US for hepatitis C was not carried out by major blood banks. With the introduction of second-generation
3847: 234: 4198: 3931: 3867: 1336: 431:. While sources vary on specific reference range values for patients, 0-40 IU/L is the standard reference range for experimental studies. 2316: 1678: 3795: 3777: 3243: 2580: 2306: 2262: 2112: 1777: 528:(Lovaza), anti-inflammatory drugs, antibiotics, cholesterol medications, some antipsychotics such as risperidone, and anticonvulsants. 1234:
Shafrir, Asher; Katz, Lior H.; Shauly-Aharonov, Michal; Zinger, Adar; Safadi, Rifaat; Stokar, Joshua; Kalisky, Itay (24 March 2024).
4150: 4010: 3265: 3233: 2368: 1877: 1470: 17: 4005: 2108: 1300: 935: 227: 3992: 3156: 1671: 4349: 3189: 1829: 829: 405:, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. 1107: 178: 1969: 1792: 2954: 1314: 3293: 3248: 2892: 2482: 2079: 1802: 3653: 2282: 1772: 1029:
Bays, Harold E.; McKenney, James; Maki, Kevin C.; Doyle, Ralph T.; Carter, Roderick N.; Stein, Evan (1 February 2010).
1180:"Low Alanine Aminotransferase Levels in the Elderly Population: Frailty, Disability, Sarcopenia, and Reduced Survival" 3326: 3149: 2277: 2194: 2103: 1535: 336: 3810: 3223: 1663: 1329: 1807: 1949: 767:
Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW (February 2009).
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Significantly elevated levels of ALT (SGPT) often suggest the existence of other medical problems such as viral
2341: 1822: 1817: 1439: 500:, so ALT is commonly used as a way of screening for liver problems. Elevated ALT may also be caused by dietary 172: 154: 4329: 3482: 3093: 2849: 2492: 2487: 2204: 1867: 1404: 159: 4268: 4145: 3644: 2785: 2747: 2430: 2381: 1848: 1425: 1322: 239: 4292: 4140: 4025: 4015: 3238: 3126: 2136: 1852: 1753: 1748: 1652: 577: 147: 1179: 816:
Vroon, David H.; Israili, Zafar (1990), Walker, H. Kenneth; Hall, W. Dallas; Hurst, J. Willis (eds.),
3583: 3570: 3557: 3544: 3531: 3518: 3505: 3467: 3228: 2677: 2477: 2472: 2425: 2386: 2031: 1457: 525: 82: 4231: 4072: 3477: 3431: 3374: 3180: 2827: 2435: 2012: 1291: 493: 485: 294: 65: 2354: 2336: 300:) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. ALT is found in 175: 4218: 4112: 3379: 2822: 2690: 2655: 2166: 2141: 2069: 2051: 1832:– this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase) 1812: 1480: 1475: 1349: 1030: 1002:
Dubbeldam JL, de Jongh HJ, Osse JW (2008). "Pieter Dullemeijer, professor of animal morphology".
427:. When used in diagnostics, it is almost always measured in international units/liter (IU/L) or 360: 99: 3595: 1309: 1287: 1139:"Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests" 4203: 3842: 3709: 3201: 3088: 2942: 2837: 2780: 2742: 2553: 2346: 2199: 1608: 589: 443:
from the laboratory that produced the result. However typical reference intervals for ALT are:
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ALT: analyte monograph; The Association for Clinical Biochemistry and Laboratory Medicine
402: 77: 3721: 1270: 1235: 111: 39: 4193: 3684: 3369: 3274: 2714: 2635: 2405: 1954: 1698: 1204: 1055: 916: 793: 768: 696: 536: 70: 1297: 1236:"Low ALT Is Associated with IBD and Disease Activity: Results from a Nationwide Study" 946: 740: 715: 639: 614: 190: 4339: 3020: 2999: 2667: 2662: 1797: 1257: 1209: 1160: 1088: 1011: 984: 908: 867: 835: 825: 798: 745: 683: 644: 166: 46: 2572: 1693: 4334: 4208: 3969: 3901: 3415: 3410: 3384: 3312: 3110: 2767: 2522: 1521: 1265: 1247: 1199: 1191: 1177: 1150: 1080: 1050: 1042: 920: 898: 788: 780: 735: 727: 691: 675: 634: 626: 565: 332: 2964: 1155: 1138: 4155: 3852: 3462: 3446: 3359: 3103: 3098: 2098: 1974: 1857: 1603: 1490: 1357: 1304: 1115: 664:"The significance of transaminase ratio (AST/ALT) in acute myocardial infarction" 561: 517: 440: 2969: 194: 4306: 4241: 3916: 3857: 3500: 3441: 3011: 2867: 2640: 2630: 409: 364: 210: 679: 4318: 4249: 4160: 4094: 3911: 3877: 3762: 3689: 3671: 3405: 3364: 3054: 3033: 2947: 2872: 2805: 2459: 2239: 1887: 1574: 1261: 972: 687: 576:, as well as increased mortality in the elderly population. In patients with 424: 317: 309: 185: 1195: 1137:
Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB (December 2000).
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Djakpo, Dodji Kossi; Wang, Zhi Quan; Shrestha, Merina (26 December 2020).
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Lala V, Goyal A, Bansal P, Minter D (July 2020). "Liver Function Tests".
731: 545: 529: 1252: 3906: 3629: 2797: 2737: 2724: 2645: 2604: 2531: 2507: 2326: 2297: 2146: 1839: 1730: 1694: 1550: 1451: 1447: 1443: 1378: 1353: 1345: 973:"Mildly elevated liver transaminase levels in the asymptomatic patient" 573: 569: 509: 394: 297: 123: 903: 886: 784: 630: 50: 4130: 3921: 3626: 3552: 3526: 2959: 2887: 2685: 2535: 2396: 2215: 2211: 2186: 2074: 2060: 2046: 2022: 489: 477: 376: 321: 822:
Clinical Methods: The History, Physical, and Laboratory Examinations
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damage can be distinguished from bile duct problems by measuring
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Association for Clinical Biochemistry and Laboratory Medicine
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Archives of Medical Science – Atherosclerotic Diseases
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and in various body tissues but is most common in the
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ALT (and all aminotransferases) require the coenzyme
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Human alanine transaminase 2 homodimer bound to PLP.
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Branched-chain alpha-keto acid dehydrogenase complex
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Branched-chain alpha-keto acid dehydrogenase complex
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Branched-chain alpha-keto acid dehydrogenase complex
580:, low ALT is associated with a more active disease. 439:
Test results should always be interpreted using the
704: 4026: 1310:Alanine aminotransferase (ALT) at Lab Tests Online 884: 714:Giannini EG, Testa R, Savarino V (February 2005). 661: 1920: 1629:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase 716:"Liver enzyme alteration: a guide for clinicians" 613:Karmen A, Wroblewski F, Ladue JS (January 1955). 331:of ALT in the circulation approximates 47 hours. 4316: 4073: 4219: 4113: 1873:Aminocarboxymuconate-semialdehyde decarboxylase 885:Ghouri N, Preiss D, Sattar N (September 2010). 866:. Treasure Island (FL): StatPearls Publishing. 520:. Many drugs may elevate ALT levels, including 419:ALT is commonly measured clinically as part of 3998:Tooltip Glutamine aminohydrolase (glutaminase) 3611: 3320: 3157: 2588: 1679: 1330: 936:"Alanine aminotransferase: analyte monograph" 532:(acetaminophen) may also elevate ALT levels. 4181: 1063: 815: 2317:3-hydroxy-2-methylbutyryl-CoA dehydrogenase 964: 857: 855: 760: 4277:Metabotropic glutamate receptor modulators 3659:Tooltip Excitatory amino acid transporters 3618: 3604: 3327: 3313: 3244:Branched-chain amino acid aminotransferase 3164: 3150: 2595: 2581: 2307:Branched-chain amino acid aminotransferase 2263:Branched-chain amino acid aminotransferase 1778:Branched-chain amino acid aminotransferase 1686: 1672: 1337: 1323: 38: 2288:Methylmalonate semialdehyde dehydrogenase 1290:at the U.S. National Library of Medicine 1269: 1251: 1203: 1154: 1054: 902: 878: 792: 739: 695: 638: 4281:GABA metabolism and transport modulators 4273:Ionotropic glutamate receptor modulators 3816:Tooltip Vesicular glutamate transporters 1878:Aminomuconate-semialdehyde dehydrogenase 1471:Glyceraldehyde 3-phosphate dehydrogenase 1004:Acta Morphologica Neerlando-Scandinavica 933: 852: 414: 393: 386:-alanine + Îą-ketoglutarate ⇌ pyruvate + 2109:1-Pyrroline-5-carboxylate dehydrogenase 1105: 970: 320:) are routinely measured clinically as 14: 4317: 2369:Betaine-homocysteine methyltransferase 824:(3rd ed.), Boston: Butterworths, 615:"Transaminase activity in human blood" 560:Low plasma ALT can be a marker of low 3853:Amido black 10B (naphthol blue black) 3599: 3308: 3145: 2576: 1830:Template:Leucine metabolism in humans 1667: 1318: 1112:American Red Cross of Tompkins County 619:The Journal of Clinical Investigation 272:serum glutamate-pyruvate transaminase 3234:Kynurenine—oxoglutarate transaminase 1970:Guanidinoacetate N-methyltransferase 720:Canadian Medical Association Journal 308:. It catalyzes the two parts of the 2893:Glycogen phosphorylase isoenzyme BB 2483:4-Hydroxyphenylpyruvate dioxygenase 2080:Formiminotransferase cyclodeaminase 1803:Isovaleryl coenzyme A dehydrogenase 280:serum glutamic-pyruvic transaminase 24: 4031:Tooltip Aspartate aminotransferase 2283:3-hydroxyisobutyrate dehydrogenase 1773:3-Hydroxybutyryl-CoA dehydrogenase 434: 363:, the products of this reversible 25: 4361: 2278:3-hydroxyisobutyryl-CoA hydrolase 2195:Gamma-glutamylcysteine synthetase 2104:Pyrroline-5-carboxylate reductase 1536:Phosphoenolpyruvate carboxykinase 1281: 347:ALT catalyzes the transfer of an 4300: 4078:Tooltip Alanine aminotransferase 3294:Pyridoxine 5'-phosphate synthase 4224:Tooltip Glutamate decarboxylase 4118:Tooltip Glutamate dehydrogenase 3249:Alanine—glyoxylate transaminase 1950:Serine hydroxymethyltransferase 1227: 1171: 1130: 1099: 1022: 995: 4209:Phosphinothricin (glufosinate) 2364:Homocysteine methyltransferase 2342:Methionine adenosyltransferase 1823:Methylglutaconyl-CoA hydratase 1818:Methylcrotonyl-CoA carboxylase 1440:Fructose-bisphosphate aldolase 1108:"Red Cross Donor Requirements" 945:. pp. 3–7. Archived from 927: 809: 655: 606: 312:. Serum ALT level, serum AST ( 13: 1: 4269:Receptor/signaling modulators 2850:Comprehensive metabolic panel 2493:Fumarylacetoacetate hydrolase 2488:Homogentisate 1,2-dioxygenase 2205:Gamma-glutamyl transpeptidase 1868:3-hydroxyanthranilate oxidase 1808:Îą-Ketoisocaproate dioxygenase 600: 4350:Glutamate (neurotransmitter) 4186:Tooltip Glutamine synthetase 1240:Journal of Clinical Medicine 7: 3334: 2786:Thyroid-stimulating hormone 2748:Total iron-binding capacity 2431:Methylmalonyl CoA epimerase 2382:Cystathionine beta synthase 1849:Indoleamine 2,3-dioxygenase 1426:Fructose 1,6-bisphosphatase 1184:The Journals of Gerontology 1156:10.1093/clinchem/46.12.2027 583: 342: 10: 4366: 3239:Ornithine aminotransferase 3127:Elevated alpha-fetoprotein 2355:regeneration of methionine 2337:generation of homocysteine 2137:Ornithine aminotransferase 1853:Tryptophan 2,3-dioxygenase 1754:Glutaryl-CoA dehydrogenase 1749:Saccharopine dehydrogenase 1653:Bisphosphoglycerate mutase 578:inflammatory bowel disease 555: 423:and is a component of the 407: 316:) level, and their ratio ( 4262: 4217: 4179: 4111: 4071: 4024: 3991: 3982: 3912:Glutamic acid (glutamate) 3878:Aspartic acid (aspartate) 3809: 3733:-CCG-III ((2S,3S,4R)-CCG) 3690:Glutamic acid (glutamate) 3672:Aspartic acid (aspartate) 3652: 3643: 3491: 3483:Michaelis–Menten kinetics 3455: 3424: 3393: 3342: 3283: 3264: 3229:Tyrosine aminotransferase 3188: 3119: 3079: 3072: 3042: 3019: 3010: 2980: 2901: 2858: 2796: 2766: 2723: 2676: 2611: 2530: 2520: 2478:Tyrosine aminotransferase 2473:Phenylalanine hydroxylase 2458: 2448: 2426:Propionyl-CoA carboxylase 2414: 2395: 2387:Cystathionine gamma-lyase 2325: 2296: 2252: 2237: 2175: 2155: 2126: 2088: 2059: 2044: 2032:L-threonine dehydrogenase 2021: 2002: 1983: 1935: 1911: 1886: 1838: 1762: 1738: 1725: 1713: 1621: 1592: 1568: 1544: 1519: 1512: 1466: 1458:Triosephosphate isomerase 1435: 1374: 1367: 977:American Family Physician 971:Giboney PT (March 2005). 680:10.5114/amsad.2020.103028 526:omega−3-acid ethyl esters 233: 221: 209: 204: 200: 184: 165: 153: 141: 129: 117: 105: 93: 88: 76: 64: 59: 37: 32: 4232:3-Mercaptopropionic acid 3741:-Serine-O-sulphate (SOS) 3375:Diffusion-limited enzyme 2436:Methylmalonyl-CoA mutase 2013:D-cysteine desulfhydrase 1292:Medical Subject Headings 494:infectious mononucleosis 486:congestive heart failure 260:alanine aminotransferase 18:Alanine aminotransferase 4039:2-Amino-3-butenoic acid 3833:6-(4'-Phenylstyryl)-QDC 3717:-3-Hydroxyaspartic acid 2656:BUN-to-creatinine ratio 2167:Glutamate dehydrogenase 2142:Ornithine decarboxylase 2070:Histidine ammonia-lyase 1813:Leucine 2,3-aminomutase 1481:Phosphoglycerate mutase 1476:Phosphoglycerate kinase 1350:carbohydrate metabolism 1035:Mayo Clinic Proceedings 564:and is associated with 4204:Methionine sulfoximine 3791:-3-Methylglutamic acid 3202:Aspartate transaminase 3089:Elevated transaminases 2781:Thyroid function tests 2743:Transferrin saturation 2603:Clinical biochemistry 2554:Aspartate transaminase 2377:conversion to cysteine 2347:Adenosylhomocysteinase 2200:Glutathione synthetase 1609:Glycerol dehydrogenase 590:Aspartate transaminase 398: 314:aspartate transaminase 3468:Eadie–Hofstee diagram 3401:Allosteric regulation 3268:: Oximinotransferases 2883:Lactate dehydrogenase 2845:Basic metabolic panel 2776:ACTH stimulation test 2549:Asparagine synthetase 1717:Essential amino acids 1560:Lactate dehydrogenase 1410:Phosphofructokinase 1 1399:Glucose 6-phosphatase 1303:8 August 2014 at the 1196:10.1093/gerona/glx126 1085:10.1001/jama.296.1.87 1047:10.4065/mcp.2009.0397 415:Clinical significance 408:Further information: 397: 4330:Liver function tests 4058:-Methylene-aspartate 3478:Lineweaver–Burk plot 3219:Alanine transaminase 2903:Liver function tests 2758:Transferrin receptor 2220:Glutamine synthetase 1994:Alanine transaminase 1584:Alanine transaminase 1531:Pyruvate carboxylase 1513:Gluconeogenesis only 1288:Alanine+transaminase 732:10.1503/cmaj.1040752 595:Liver function tests 514:alkaline phosphatase 421:liver function tests 252:Alanine transaminase 33:Alanine transaminase 4171:Pyridoxal phosphate 3873:Chicago sky blue 6B 3838:6-Biphenyl-4-yl-QDC 2919:Serum total protein 2914:Human serum albumin 2360:Methionine synthase 2273:Enoyl-CoA hydratase 2158:alpha-ketoglutarate 2075:Urocanate hydratase 1788:Enoyl-CoA hydratase 1253:10.3390/jcm13071869 934:Marshall W (2012). 818:"Aminotransferases" 544:antibody tests for 403:pyridoxal phosphate 4194:2-Aminoadipic acid 4063:Hydrazinosuccinate 3437:Enzyme superfamily 3370:Enzyme promiscuity 3275:Oximinotransferase 2691:Arterial blood gas 2406:Threonine aldolase 1955:Serine dehydratase 1699:Protein metabolism 1143:Clinical Chemistry 1118:on 3 November 2005 537:American Red Cross 399: 324:for liver health. 4288: 4287: 4258: 4257: 4244: 3978: 3977: 3896: 3893:Erythro-4-methyl- 3827: 3748: 3740: 3732: 3724: 3712: 3593: 3592: 3302: 3301: 3224:GABA transaminase 3139: 3138: 3135: 3134: 3068: 3067: 3021:Blood sugar level 3000:Pancreatic lipase 2838:Total cholesterol 2668:Serum osmolal gap 2663:Plasma osmolality 2570: 2569: 2566: 2565: 2562: 2561: 2516: 2515: 2444: 2443: 2233: 2232: 2040: 2039: 1907: 1906: 1798:HMG-CoA reductase 1661: 1660: 1617: 1616: 1508: 1507: 1405:Glucose isomerase 904:10.1002/hep.23789 831:978-0-409-90077-4 785:10.1002/hep.22657 631:10.1172/JCI103055 474: 473: 454:Reference ranges 389: 385: 374: 354: 258:), also known as 249: 248: 245: 244: 148:metabolic pathway 27:Mammalian protein 16:(Redirected from 4357: 4305: 4304: 4296: 4242: 4225: 4221: 4187: 4183: 4119: 4115: 4103:Propargylglycine 4097: 4089: 4079: 4075: 4057: 4032: 4028: 3999: 3995: 3989: 3988: 3970:Xanthurenic acid 3894: 3863:Benzopurpurin 4B 3825: 3817: 3813: 3746: 3738: 3730: 3722: 3710: 3660: 3656: 3650: 3649: 3620: 3613: 3606: 3597: 3596: 3473:Hanes–Woolf plot 3416:Enzyme activator 3411:Enzyme inhibitor 3385:Enzyme catalysis 3329: 3322: 3315: 3306: 3305: 3166: 3159: 3152: 3143: 3142: 3111:Hyperproteinemia 3077: 3076: 3017: 3016: 2597: 2590: 2583: 2574: 2573: 2528: 2527: 2456: 2455: 2250: 2249: 2057: 2056: 1933: 1932: 1918: 1917: 1736: 1735: 1688: 1681: 1674: 1665: 1664: 1517: 1516: 1372: 1371: 1339: 1332: 1325: 1316: 1315: 1276: 1275: 1273: 1255: 1231: 1225: 1224: 1222: 1220: 1207: 1175: 1169: 1168: 1158: 1134: 1128: 1127: 1125: 1123: 1114:. Archived from 1103: 1097: 1096: 1067: 1061: 1060: 1058: 1026: 1020: 1019: 999: 993: 992: 968: 962: 961: 959: 957: 952:on 8 August 2014 951: 940: 931: 925: 924: 906: 882: 876: 875: 859: 850: 849: 848: 846: 813: 807: 806: 796: 764: 758: 757: 743: 711: 702: 701: 699: 659: 653: 652: 642: 610: 488:, liver damage, 446: 445: 387: 383: 372: 352: 337:sinusoidal cells 333:Aminotransferase 202: 201: 53: 42: 30: 29: 21: 4365: 4364: 4360: 4359: 4358: 4356: 4355: 4354: 4315: 4314: 4311: 4299: 4291: 4289: 4284: 4254: 4223: 4213: 4185: 4175: 4156:Hexachlorophene 4117: 4107: 4095: 4087: 4077: 4067: 4055: 4030: 4020: 3997: 3974: 3937:Reactive blue 2 3815: 3805: 3658: 3639: 3624: 3594: 3589: 3501:Oxidoreductases 3487: 3463:Enzyme kinetics 3451: 3447:List of enzymes 3420: 3389: 3360:Catalytic triad 3338: 3333: 3303: 3298: 3279: 3260: 3184: 3170: 3140: 3131: 3115: 3104:Hypoalbuminemia 3099:Hypoproteinemia 3064: 3038: 3012:Small molecules 3006: 2976: 2897: 2854: 2792: 2762: 2719: 2709: 2672: 2607: 2601: 2571: 2558: 2512: 2440: 2410: 2391: 2321: 2292: 2243: 2229: 2171: 2151: 2122: 2099:Proline oxidase 2084: 2052:Îą-ketoglutarate 2050: 2036: 2017: 1998: 1979: 1975:Creatine kinase 1925: 1903: 1882: 1858:Arylformamidase 1834: 1758: 1721: 1719:are in Capitals 1709: 1705:and catabolism 1692: 1662: 1657: 1613: 1604:Glycerol kinase 1588: 1564: 1540: 1504: 1491:Pyruvate kinase 1462: 1431: 1363: 1358:gluconeogenesis 1343: 1305:Wayback Machine 1284: 1279: 1232: 1228: 1218: 1216: 1176: 1172: 1149:(12): 2027–49. 1135: 1131: 1121: 1119: 1106:Van Ostrand D. 1104: 1100: 1068: 1064: 1027: 1023: 1000: 996: 969: 965: 955: 953: 949: 938: 932: 928: 883: 879: 860: 853: 844: 842: 832: 814: 810: 765: 761: 712: 705: 660: 656: 611: 607: 603: 586: 558: 535:For years, the 518:creatine kinase 441:reference range 437: 435:Elevated levels 417: 412: 367:reaction being 361:Îą-ketoglutarate 345: 55: 45: 28: 23: 22: 15: 12: 11: 5: 4363: 4353: 4352: 4347: 4342: 4337: 4332: 4327: 4310: 4309: 4286: 4285: 4263: 4260: 4259: 4256: 4255: 4253: 4252: 4247: 4239: 4234: 4228: 4226: 4215: 4214: 4212: 4211: 4206: 4201: 4196: 4190: 4188: 4177: 4176: 4174: 4173: 4168: 4163: 4158: 4153: 4148: 4143: 4138: 4133: 4128: 4122: 4120: 4109: 4108: 4106: 4105: 4100: 4092: 4082: 4080: 4069: 4068: 4066: 4065: 4060: 4051: 4046: 4041: 4035: 4033: 4022: 4021: 4019: 4018: 4013: 4008: 4002: 4000: 3986: 3980: 3979: 3976: 3975: 3973: 3972: 3967: 3962: 3957: 3949: 3944: 3939: 3934: 3929: 3924: 3919: 3917:Kynurenic acid 3914: 3909: 3904: 3899: 3897:-glutamic acid 3890: 3888:Direct blue 71 3885: 3880: 3875: 3870: 3865: 3860: 3858:Bafilomycin A1 3855: 3850: 3845: 3840: 3835: 3830: 3820: 3818: 3807: 3806: 3804: 3803: 3798: 3793: 3785: 3780: 3775: 3770: 3765: 3760: 3755: 3743: 3735: 3727: 3719: 3707: 3702: 3697: 3692: 3687: 3682: 3674: 3669: 3663: 3661: 3647: 3641: 3640: 3623: 3622: 3615: 3608: 3600: 3591: 3590: 3588: 3587: 3574: 3561: 3548: 3535: 3522: 3509: 3495: 3493: 3489: 3488: 3486: 3485: 3480: 3475: 3470: 3465: 3459: 3457: 3453: 3452: 3450: 3449: 3444: 3439: 3434: 3428: 3426: 3425:Classification 3422: 3421: 3419: 3418: 3413: 3408: 3403: 3397: 3395: 3391: 3390: 3388: 3387: 3382: 3377: 3372: 3367: 3362: 3357: 3352: 3346: 3344: 3340: 3339: 3332: 3331: 3324: 3317: 3309: 3300: 3299: 3297: 3296: 3290: 3288: 3281: 3280: 3278: 3277: 3271: 3269: 3262: 3261: 3259: 3258: 3257: 3256: 3246: 3241: 3236: 3231: 3226: 3221: 3216: 3215: 3214: 3209: 3198: 3196: 3186: 3185: 3169: 3168: 3161: 3154: 3146: 3137: 3136: 3133: 3132: 3130: 3129: 3123: 3121: 3117: 3116: 3114: 3113: 3108: 3107: 3106: 3096: 3091: 3085: 3083: 3074: 3070: 3069: 3066: 3065: 3063: 3062: 3057: 3052: 3046: 3044: 3040: 3039: 3037: 3036: 3031: 3025: 3023: 3014: 3008: 3007: 3005: 3004: 3003: 3002: 2992: 2986: 2984: 2978: 2977: 2975: 2974: 2973: 2972: 2967: 2957: 2952: 2951: 2950: 2945: 2940: 2928: 2923: 2922: 2921: 2916: 2907: 2905: 2899: 2898: 2896: 2895: 2890: 2885: 2880: 2875: 2870: 2868:Cardiac marker 2864: 2862: 2860:Cardiovascular 2856: 2855: 2853: 2852: 2847: 2842: 2841: 2840: 2835: 2830: 2825: 2815: 2814: 2813: 2811:Hemoglobin A1c 2802: 2800: 2794: 2793: 2791: 2790: 2789: 2788: 2778: 2772: 2770: 2764: 2763: 2761: 2760: 2755: 2750: 2745: 2740: 2735: 2729: 2727: 2721: 2720: 2718: 2717: 2712: 2707: 2703: 2698: 2693: 2688: 2682: 2680: 2674: 2673: 2671: 2670: 2665: 2660: 2659: 2658: 2653: 2648: 2641:Renal function 2638: 2633: 2628: 2623: 2617: 2615: 2609: 2608: 2600: 2599: 2592: 2585: 2577: 2568: 2567: 2564: 2563: 2560: 2559: 2557: 2556: 2551: 2541: 2539: 2525: 2518: 2517: 2514: 2513: 2511: 2510: 2496: 2495: 2490: 2485: 2480: 2475: 2469: 2467: 2453: 2446: 2445: 2442: 2441: 2439: 2438: 2433: 2428: 2422: 2420: 2412: 2411: 2409: 2408: 2402: 2400: 2393: 2392: 2390: 2389: 2384: 2372: 2371: 2366: 2350: 2349: 2344: 2332: 2330: 2323: 2322: 2320: 2319: 2314: 2309: 2303: 2301: 2294: 2293: 2291: 2290: 2285: 2280: 2275: 2270: 2265: 2259: 2257: 2247: 2235: 2234: 2231: 2230: 2228: 2227: 2222: 2208: 2207: 2202: 2197: 2179: 2177: 2173: 2172: 2170: 2169: 2163: 2161: 2153: 2152: 2150: 2149: 2144: 2139: 2133: 2131: 2124: 2123: 2121: 2120: 2115: 2106: 2101: 2095: 2093: 2086: 2085: 2083: 2082: 2077: 2072: 2066: 2064: 2054: 2042: 2041: 2038: 2037: 2035: 2034: 2028: 2026: 2019: 2018: 2016: 2015: 2009: 2007: 2000: 1999: 1997: 1996: 1990: 1988: 1981: 1980: 1978: 1977: 1972: 1958: 1957: 1952: 1946: 1944: 1930: 1915: 1909: 1908: 1905: 1904: 1902: 1901: 1897: 1895: 1884: 1883: 1881: 1880: 1875: 1870: 1865: 1860: 1855: 1845: 1843: 1836: 1835: 1826: 1825: 1820: 1815: 1810: 1805: 1800: 1795: 1790: 1785: 1780: 1775: 1769: 1767: 1760: 1759: 1757: 1756: 1751: 1745: 1743: 1733: 1723: 1722: 1714: 1711: 1710: 1691: 1690: 1683: 1676: 1668: 1659: 1658: 1656: 1655: 1650: 1649: 1648: 1625: 1623: 1619: 1618: 1615: 1614: 1612: 1611: 1606: 1600: 1598: 1590: 1589: 1587: 1586: 1580: 1578: 1566: 1565: 1563: 1562: 1556: 1554: 1542: 1541: 1539: 1538: 1533: 1527: 1525: 1514: 1510: 1509: 1506: 1505: 1503: 1502: 1488: 1483: 1478: 1473: 1467: 1464: 1463: 1461: 1460: 1455: 1436: 1433: 1432: 1430: 1429: 1407: 1402: 1375: 1369: 1365: 1364: 1342: 1341: 1334: 1327: 1319: 1313: 1312: 1307: 1295: 1283: 1282:External links 1280: 1278: 1277: 1226: 1190:(7): 925–930. 1170: 1129: 1098: 1062: 1041:(2): 122–128. 1021: 994: 983:(6): 1105–10. 963: 926: 897:(3): 1156–61. 877: 851: 830: 808: 779:(2): 598–607. 759: 703: 674:(1): 279–283. 654: 604: 602: 599: 598: 597: 592: 585: 582: 557: 554: 472: 471: 468: 464: 463: 460: 456: 455: 452: 436: 433: 416: 413: 410:Prati criteria 392: 391: 365:transamination 344: 341: 339:in the liver. 335:is cleared by 247: 246: 243: 242: 237: 231: 230: 225: 219: 218: 213: 207: 206: 198: 197: 188: 182: 181: 170: 163: 162: 157: 151: 150: 145: 139: 138: 133: 127: 126: 121: 115: 114: 109: 103: 102: 97: 91: 90: 86: 85: 80: 74: 73: 68: 62: 61: 57: 56: 43: 35: 34: 26: 9: 6: 4: 3: 2: 4362: 4351: 4348: 4346: 4343: 4341: 4338: 4336: 4333: 4331: 4328: 4326: 4323: 4322: 4320: 4313: 4308: 4303: 4298: 4297: 4294: 4283: 4282: 4278: 4274: 4270: 4267: 4261: 4251: 4250:Semicarbazide 4248: 4246: 4245:-Allylglycine 4240: 4238: 4235: 4233: 4230: 4229: 4227: 4222: 4216: 4210: 4207: 4205: 4202: 4200: 4197: 4195: 4192: 4191: 4189: 4184: 4178: 4172: 4169: 4167: 4166:Palmitoyl-CoA 4164: 4162: 4161:Hydroxylamine 4159: 4157: 4154: 4152: 4149: 4147: 4144: 4142: 4139: 4137: 4134: 4132: 4129: 4127: 4124: 4123: 4121: 4116: 4110: 4104: 4101: 4099: 4093: 4091: 4084: 4083: 4081: 4076: 4070: 4064: 4061: 4059: 4052: 4050: 4047: 4045: 4042: 4040: 4037: 4036: 4034: 4029: 4023: 4017: 4014: 4012: 4009: 4007: 4004: 4003: 4001: 3996: 3990: 3987: 3985: 3981: 3971: 3968: 3966: 3963: 3961: 3958: 3956: 3954: 3950: 3948: 3945: 3943: 3940: 3938: 3935: 3933: 3930: 3928: 3925: 3923: 3920: 3918: 3915: 3913: 3910: 3908: 3905: 3903: 3900: 3898: 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3869: 3866: 3864: 3861: 3859: 3856: 3854: 3851: 3849: 3846: 3844: 3841: 3839: 3836: 3834: 3831: 3829: 3822: 3821: 3819: 3814: 3808: 3802: 3799: 3797: 3794: 3792: 3790: 3786: 3784: 3781: 3779: 3776: 3774: 3771: 3769: 3766: 3764: 3763:Maslinic acid 3761: 3759: 3756: 3754: 3752: 3744: 3742: 3736: 3734: 3728: 3726: 3720: 3718: 3716: 3708: 3706: 3703: 3701: 3698: 3696: 3693: 3691: 3688: 3686: 3683: 3681: 3679: 3675: 3673: 3670: 3668: 3665: 3664: 3662: 3657: 3651: 3648: 3646: 3642: 3638: 3635: 3631: 3628: 3621: 3616: 3614: 3609: 3607: 3602: 3601: 3598: 3585: 3581: 3580: 3575: 3572: 3568: 3567: 3562: 3559: 3555: 3554: 3549: 3546: 3542: 3541: 3536: 3533: 3529: 3528: 3523: 3520: 3516: 3515: 3510: 3507: 3503: 3502: 3497: 3496: 3494: 3490: 3484: 3481: 3479: 3476: 3474: 3471: 3469: 3466: 3464: 3461: 3460: 3458: 3454: 3448: 3445: 3443: 3442:Enzyme family 3440: 3438: 3435: 3433: 3430: 3429: 3427: 3423: 3417: 3414: 3412: 3409: 3407: 3406:Cooperativity 3404: 3402: 3399: 3398: 3396: 3392: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3368: 3366: 3365:Oxyanion hole 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3347: 3345: 3341: 3337: 3330: 3325: 3323: 3318: 3316: 3311: 3310: 3307: 3295: 3292: 3291: 3289: 3286: 3282: 3276: 3273: 3272: 3270: 3267: 3263: 3255: 3252: 3251: 3250: 3247: 3245: 3242: 3240: 3237: 3235: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3213: 3210: 3208: 3205: 3204: 3203: 3200: 3199: 3197: 3195: 3194:Transaminases 3191: 3187: 3182: 3178: 3174: 3167: 3162: 3160: 3155: 3153: 3148: 3147: 3144: 3128: 3125: 3124: 3122: 3118: 3112: 3109: 3105: 3102: 3101: 3100: 3097: 3095: 3092: 3090: 3087: 3086: 3084: 3082: 3078: 3075: 3071: 3061: 3058: 3056: 3055:Hyperuricemia 3053: 3051: 3048: 3047: 3045: 3041: 3035: 3034:Hyperglycemia 3032: 3030: 3027: 3026: 3024: 3022: 3018: 3015: 3013: 3009: 3001: 2998: 2997: 2996: 2993: 2991: 2988: 2987: 2985: 2983: 2979: 2971: 2968: 2966: 2963: 2962: 2961: 2958: 2956: 2953: 2949: 2948:AST/ALT ratio 2946: 2944: 2941: 2939: 2936: 2935: 2934: 2933: 2932:transaminases 2929: 2927: 2924: 2920: 2917: 2915: 2912: 2911: 2909: 2908: 2906: 2904: 2900: 2894: 2891: 2889: 2886: 2884: 2881: 2879: 2876: 2874: 2873:Troponin test 2871: 2869: 2866: 2865: 2863: 2861: 2857: 2851: 2848: 2846: 2843: 2839: 2836: 2834: 2833:Triglycerides 2831: 2829: 2826: 2824: 2821: 2820: 2819: 2816: 2812: 2809: 2808: 2807: 2806:Blood glucose 2804: 2803: 2801: 2799: 2795: 2787: 2784: 2783: 2782: 2779: 2777: 2774: 2773: 2771: 2769: 2765: 2759: 2756: 2754: 2751: 2749: 2746: 2744: 2741: 2739: 2736: 2734: 2731: 2730: 2728: 2726: 2722: 2716: 2713: 2711: 2704: 2702: 2699: 2697: 2694: 2692: 2689: 2687: 2684: 2683: 2681: 2679: 2675: 2669: 2666: 2664: 2661: 2657: 2654: 2652: 2649: 2647: 2644: 2643: 2642: 2639: 2637: 2634: 2632: 2629: 2627: 2624: 2622: 2619: 2618: 2616: 2614: 2610: 2606: 2598: 2593: 2591: 2586: 2584: 2579: 2578: 2575: 2555: 2552: 2550: 2546: 2543: 2542: 2540: 2537: 2533: 2529: 2526: 2524: 2519: 2509: 2505: 2501: 2498: 2497: 2494: 2491: 2489: 2486: 2484: 2481: 2479: 2476: 2474: 2471: 2470: 2468: 2465: 2461: 2460:PHENYLALANINE 2457: 2454: 2452: 2447: 2437: 2434: 2432: 2429: 2427: 2424: 2423: 2421: 2418: 2413: 2407: 2404: 2403: 2401: 2398: 2394: 2388: 2385: 2383: 2380: 2378: 2374: 2373: 2370: 2367: 2365: 2361: 2358: 2356: 2352: 2351: 2348: 2345: 2343: 2340: 2338: 2334: 2333: 2331: 2328: 2324: 2318: 2315: 2313: 2310: 2308: 2305: 2304: 2302: 2299: 2295: 2289: 2286: 2284: 2281: 2279: 2276: 2274: 2271: 2269: 2266: 2264: 2261: 2260: 2258: 2255: 2251: 2248: 2246: 2241: 2240:propionyl-CoA 2236: 2226: 2223: 2221: 2217: 2213: 2210: 2209: 2206: 2203: 2201: 2198: 2196: 2192: 2188: 2184: 2181: 2180: 2178: 2174: 2168: 2165: 2164: 2162: 2159: 2154: 2148: 2145: 2143: 2140: 2138: 2135: 2134: 2132: 2129: 2125: 2119: 2116: 2114: 2110: 2107: 2105: 2102: 2100: 2097: 2096: 2094: 2091: 2087: 2081: 2078: 2076: 2073: 2071: 2068: 2067: 2065: 2062: 2058: 2055: 2053: 2048: 2043: 2033: 2030: 2029: 2027: 2024: 2020: 2014: 2011: 2010: 2008: 2005: 2001: 1995: 1992: 1991: 1989: 1986: 1982: 1976: 1973: 1971: 1967: 1963: 1960: 1959: 1956: 1953: 1951: 1948: 1947: 1945: 1942: 1938: 1934: 1931: 1929: 1924: 1919: 1916: 1914: 1910: 1899: 1898: 1896: 1893: 1889: 1888:PHENYLALANINE 1885: 1879: 1876: 1874: 1871: 1869: 1866: 1864: 1861: 1859: 1856: 1854: 1850: 1847: 1846: 1844: 1841: 1837: 1833: 1831: 1824: 1821: 1819: 1816: 1814: 1811: 1809: 1806: 1804: 1801: 1799: 1796: 1794: 1793:HMG-CoA lyase 1791: 1789: 1786: 1784: 1781: 1779: 1776: 1774: 1771: 1770: 1768: 1765: 1761: 1755: 1752: 1750: 1747: 1746: 1744: 1741: 1737: 1734: 1732: 1728: 1724: 1720: 1718: 1712: 1708: 1704: 1700: 1696: 1689: 1684: 1682: 1677: 1675: 1670: 1669: 1666: 1654: 1651: 1647: 1643: 1639: 1635: 1632: 1631: 1630: 1627: 1626: 1624: 1620: 1610: 1607: 1605: 1602: 1601: 1599: 1596: 1591: 1585: 1582: 1581: 1579: 1576: 1575:Alanine cycle 1572: 1567: 1561: 1558: 1557: 1555: 1552: 1548: 1543: 1537: 1534: 1532: 1529: 1528: 1526: 1523: 1518: 1515: 1511: 1500: 1496: 1492: 1489: 1487: 1484: 1482: 1479: 1477: 1474: 1472: 1469: 1468: 1465: 1459: 1456: 1453: 1449: 1445: 1441: 1438: 1437: 1434: 1427: 1423: 1419: 1415: 1411: 1408: 1406: 1403: 1400: 1396: 1392: 1388: 1384: 1380: 1377: 1376: 1373: 1370: 1366: 1362: 1359: 1355: 1351: 1347: 1340: 1335: 1333: 1328: 1326: 1321: 1320: 1317: 1311: 1308: 1306: 1302: 1299: 1296: 1293: 1289: 1286: 1285: 1272: 1267: 1263: 1259: 1254: 1249: 1245: 1241: 1237: 1230: 1215: 1211: 1206: 1201: 1197: 1193: 1189: 1185: 1181: 1174: 1166: 1162: 1157: 1152: 1148: 1144: 1140: 1133: 1117: 1113: 1109: 1102: 1094: 1090: 1086: 1082: 1078: 1074: 1066: 1057: 1052: 1048: 1044: 1040: 1036: 1032: 1025: 1017: 1013: 1010:(1–2): 9–16. 1009: 1005: 998: 990: 986: 982: 978: 974: 967: 948: 944: 937: 930: 922: 918: 914: 910: 905: 900: 896: 892: 888: 881: 873: 869: 865: 858: 856: 841: 837: 833: 827: 823: 819: 812: 804: 800: 795: 790: 786: 782: 778: 774: 770: 763: 756: 751: 747: 742: 737: 733: 729: 726:(3): 367–79. 725: 721: 717: 710: 708: 698: 693: 689: 685: 681: 677: 673: 669: 665: 658: 650: 646: 641: 636: 632: 628: 625:(1): 126–31. 624: 620: 616: 609: 605: 596: 593: 591: 588: 587: 581: 579: 575: 571: 567: 563: 553: 549: 547: 543: 538: 533: 531: 527: 523: 519: 515: 511: 506: 503: 499: 495: 491: 487: 483: 479: 469: 466: 465: 461: 458: 457: 453: 451: 448: 447: 444: 442: 432: 430: 426: 425:AST/ALT ratio 422: 411: 406: 404: 396: 382: 381: 380: 378: 370: 366: 362: 358: 350: 340: 338: 334: 330: 325: 323: 319: 318:AST/ALT ratio 315: 311: 310:alanine cycle 307: 303: 299: 296: 292: 289: 285: 281: 277: 273: 269: 265: 261: 257: 253: 241: 238: 236: 232: 229: 226: 224: 220: 217: 214: 212: 208: 203: 199: 196: 192: 189: 187: 186:Gene Ontology 183: 180: 177: 174: 171: 168: 164: 161: 158: 156: 152: 149: 146: 144: 140: 137: 134: 132: 128: 125: 124:NiceZyme view 122: 120: 116: 113: 110: 108: 104: 101: 98: 96: 92: 87: 84: 81: 79: 75: 72: 69: 67: 63: 58: 52: 48: 41: 36: 31: 19: 4312: 4265: 4264: 4098:-Cycloserine 3952: 3848:Acid red 114 3824:4-Methylene- 3788: 3750: 3714: 3677: 3579:Translocases 3576: 3563: 3550: 3537: 3524: 3514:Transferases 3511: 3498: 3355:Binding site 3218: 3094:Elevated ALP 3060:Hypouricemia 3029:Hypoglycemia 2965:Unconjugated 2937: 2930: 2613:Electrolytes 2545:Asparaginase 2523:oxaloacetate 2417:succinyl-CoA 2375: 2353: 2335: 2245:succinyl-CoA 1993: 1863:Kynureninase 1827: 1715: 1583: 1522:oxaloacetate 1243: 1239: 1229: 1217:. Retrieved 1187: 1183: 1173: 1146: 1142: 1132: 1120:. Retrieved 1116:the original 1111: 1101: 1079:(1): 87–93. 1076: 1072: 1065: 1038: 1034: 1024: 1007: 1003: 997: 980: 976: 966: 954:. Retrieved 947:the original 942: 929: 894: 890: 880: 863: 843:, retrieved 821: 811: 776: 772: 762: 753: 723: 719: 671: 667: 657: 622: 618: 608: 559: 550: 534: 507: 475: 450:Patient type 449: 438: 418: 400: 346: 326: 288:transaminase 283: 279: 275: 271: 270:), formerly 267: 263: 259: 255: 251: 250: 112:BRENDA entry 4136:Chloroquine 3965:Valinomycin 3960:Trypan blue 3942:Rose bengal 3927:NPPB (N144) 3801:WAY-213,613 3705:Kainic acid 3667:Amphetamine 3645:Transporter 3350:Active site 3177:nitrogenous 3173:Transferase 3043:Nitrogenous 2878:CPK-MB test 2818:Lipid panel 2753:Transferrin 2701:Bicarbonate 2696:Base excess 2605:blood tests 2225:Glutaminase 2191:glutathione 1900:(see below) 1395:Glucokinase 1246:(7): 1869. 864:Stat Pearls 562:muscle mass 546:hepatitis C 530:Paracetamol 351:group from 100:IntEnz view 60:Identifiers 4345:Hepatology 4325:Biomarkers 4319:Categories 4199:JFD01307SC 3932:Ponceau SS 3907:Furosemide 3902:Evans blue 3868:Bumetamide 3828:-glutamate 3637:modulators 3630:metabolism 3553:Isomerases 3527:Hydrolases 3394:Regulation 2970:Conjugated 2798:Metabolism 2738:Serum iron 2725:Iron tests 2646:Creatinine 2532:asparagine 2508:Tyrosinase 2327:METHIONINE 2298:ISOLEUCINE 2147:Agmatinase 1840:TRYPTOPHAN 1731:acetyl-CoA 1695:Metabolism 1622:Regulatory 1551:Cori cycle 1442:(Aldolase 1379:Hexokinase 1368:Glycolysis 1354:glycolysis 1346:Metabolism 891:Hepatology 773:Hepatology 601:References 574:disability 570:sarcopenia 510:hepatocyte 492:problems, 470:≤ 34 IU/L 462:≤ 45 IU/L 390:-glutamate 322:biomarkers 169:structures 136:KEGG entry 83:9000-86-6 4266:See also: 4131:Bithionol 4086:β-Chloro- 3922:Nigericin 3634:transport 3627:Glutamate 3432:EC number 2960:Bilirubin 2910:Proteins 2888:Myoglobin 2686:Anion gap 2678:Acid-base 2626:Potassium 2536:aspartate 2397:THREONINE 2216:glutamine 2212:glutamate 2187:glutamate 2061:HISTIDINE 2047:glutamate 2023:threonine 1703:synthesis 1262:2077-0383 956:7 October 688:2451-0629 490:bile duct 478:hepatitis 377:glutamate 329:half-life 89:Databases 4340:EC 2.6.1 4090:-alanine 3796:UCPH-101 3783:Theanine 3778:TFB-TBOA 3768:SYM-2081 3753:-2,4-PDC 3456:Kinetics 3380:Cofactor 3343:Activity 3179:groups ( 3073:Proteins 3050:Azotemia 2982:Pancreas 2768:Hormones 2733:Ferritin 2631:Chloride 2500:tyrosine 2464:tyrosine 2451:fumarate 2183:cysteine 2128:arginine 2004:cysteine 1966:creatine 1923:pyruvate 1892:tyrosine 1595:glycerol 1422:Platelet 1301:Archived 1271:11012492 1219:24 March 1214:28633440 1165:11106349 1122:1 August 1093:16820551 989:15791889 913:20658466 872:29494096 840:21250265 803:19085960 750:15684121 649:13221663 584:See also 522:zileuton 498:myopathy 482:diabetes 369:pyruvate 343:Function 286:), is a 240:proteins 228:articles 216:articles 173:RCSB PDB 4335:Enzymes 4307:Biology 3566:Ligases 3336:Enzymes 3287:: Other 2990:Amylase 2715:Lactate 2710:content 2636:Calcium 2504:melanin 2113:ALDH4A1 2090:proline 1985:alanine 1962:glycine 1937:glycine 1928:citrate 1764:LEUCINE 1707:enzymes 1571:alanine 1547:lactate 1486:Enolase 1361:enzymes 1205:6001897 1056:2813819 1016:2683599 921:5141849 845:29 July 794:2917112 697:7885810 566:frailty 556:Low ALT 502:choline 357:alanine 298:2.6.1.2 195:QuickGO 160:profile 143:MetaCyc 78:CAS no. 71:2.6.1.2 54:​ 4293:Portal 4151:GW5074 4011:CB-839 3984:Enzyme 3812:vGluTs 3540:Lyases 3285:2.6.99 2995:Lipase 2621:Sodium 2254:VALINE 1941:serine 1740:LYSINE 1646:PFKFB4 1642:PFKFB3 1638:PFKFB2 1634:PFKFB1 1418:Muscle 1294:(MeSH) 1268:  1260:  1212:  1202:  1163:  1091:  1053:  1014:  987:  919:  911:  870:  838:  828:  801:  791:  748:  741:545762 738:  694:  686:  647:  640:438594 637:  467:Female 302:plasma 291:enzyme 223:PubMed 205:Search 191:AmiGO 179:PDBsum 119:ExPASy 107:BRENDA 95:IntEnz 66:EC no. 4006:BPTES 3955:-ACDP 3953:trans 3843:7-CKA 3789:threo 3751:trans 3715:threo 3713:-(-)- 3700:HIP-B 3695:HIP-A 3680:-ACBD 3655:EAATs 3492:Types 3266:2.6.3 3190:2.6.1 3120:Other 2176:Other 2118:PYCR1 1828:(See 1593:from 1569:from 1545:from 1414:Liver 950:(PDF) 939:(PDF) 917:S2CID 542:ELISA 496:, or 349:amino 306:liver 278:) or 155:PRIAM 4237:AAOA 4141:EGCG 4126:AAOA 4044:AAOA 3947:SITS 3883:DIDS 3773:TBOA 3758:MPDC 3725:-ÎąAA 3685:DHKA 3632:and 3584:list 3577:EC7 3571:list 3564:EC6 3558:list 3551:EC5 3545:list 3538:EC4 3532:list 3525:EC3 3519:list 3512:EC2 3506:list 3499:EC1 3254:AGXT 3212:GOT2 3207:GOT1 3183:2.6) 2651:Urea 2419:→TCA 2160:→TCA 1499:PKM2 1495:PKLR 1258:ISSN 1221:2024 1210:PMID 1161:PMID 1124:2005 1089:PMID 1073:JAMA 1012:PMID 985:PMID 958:2013 909:PMID 868:PMID 847:2024 836:PMID 826:ISBN 799:PMID 755:AST. 746:PMID 684:ISSN 645:PMID 459:Male 429:Îźkat 371:and 327:The 284:SGPT 268:ALAT 235:NCBI 176:PDBe 131:KEGG 51:3IHJ 4220:GAD 4146:GTP 4114:GDH 4074:ALT 4049:AMB 4027:AST 4016:DON 3994:GAH 3678:cis 3081:LFT 2955:GGT 2943:AST 2938:ALT 2926:ALP 2828:HDL 2823:LDL 1520:to 1424:)→/ 1397:)→/ 1391:HK3 1387:HK2 1383:HK1 1266:PMC 1248:doi 1200:PMC 1192:doi 1151:doi 1081:doi 1077:296 1051:PMC 1043:doi 899:doi 789:PMC 781:doi 736:PMC 728:doi 724:172 692:PMC 676:doi 635:PMC 627:doi 359:to 276:GPT 266:or 264:ALT 256:ALT 211:PMC 167:PDB 47:PDB 4321:: 4279:• 4275:• 4271:• 4182:GS 4056:DL 4054:β- 3192:: 3181:EC 3175:: 2706:CO 2521:G→ 2506:: 2449:G→ 2238:G→ 2218:: 2193:: 2045:G→ 1968:: 1921:G→ 1701:, 1697:: 1644:, 1640:, 1636:, 1577:): 1553:): 1497:, 1450:, 1446:, 1420:, 1416:, 1393:, 1389:, 1385:, 1352:: 1348:: 1264:. 1256:. 1244:13 1242:. 1238:. 1208:. 1198:. 1188:73 1186:. 1182:. 1159:. 1147:46 1145:. 1141:. 1110:. 1087:. 1075:. 1049:. 1039:85 1037:. 1033:. 1008:27 1006:. 981:71 979:. 975:. 941:. 915:. 907:. 895:52 893:. 889:. 854:^ 834:, 820:, 797:. 787:. 777:49 775:. 771:. 752:. 744:. 734:. 722:. 718:. 706:^ 690:. 682:. 670:. 666:. 643:. 633:. 623:34 621:. 617:. 572:, 568:, 524:, 484:, 480:, 379:. 295:EC 193:/ 49:: 4295:: 4243:L 4096:L 4088:L 3895:L 3826:L 3749:- 3747:L 3739:L 3731:L 3723:L 3711:L 3619:e 3612:t 3605:v 3586:) 3582:( 3573:) 3569:( 3560:) 3556:( 3547:) 3543:( 3534:) 3530:( 3521:) 3517:( 3508:) 3504:( 3328:e 3321:t 3314:v 3165:e 3158:t 3151:v 2708:2 2596:e 2589:t 2582:v 2547:/ 2538:→ 2534:→ 2502:→ 2466:→ 2462:→ 2415:→ 2399:→ 2379:: 2362:/ 2357:: 2339:: 2329:→ 2300:→ 2256:→ 2242:→ 2214:→ 2189:→ 2185:+ 2156:→ 2130:→ 2111:/ 2092:→ 2063:→ 2049:→ 2025:→ 2006:→ 1987:→ 1964:→ 1943:→ 1939:→ 1926:→ 1913:G 1894:→ 1890:→ 1851:/ 1842:→ 1766:→ 1742:→ 1729:→ 1727:K 1687:e 1680:t 1673:v 1597:: 1573:( 1549:( 1524:: 1501:) 1493:( 1454:) 1452:C 1448:B 1444:A 1428:← 1412:( 1401:← 1381:( 1356:/ 1338:e 1331:t 1324:v 1274:. 1250:: 1223:. 1194:: 1167:. 1153:: 1126:. 1095:. 1083:: 1059:. 1045:: 1018:. 991:. 960:. 923:. 901:: 874:. 805:. 783:: 730:: 700:. 678:: 672:5 651:. 629:: 388:L 384:L 375:- 373:L 355:- 353:L 293:( 282:( 274:( 262:( 254:( 20:)

Index

Alanine aminotransferase

PDB
3IHJ
EC no.
2.6.1.2
CAS no.
9000-86-6
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB
RCSB PDB
PDBe
PDBsum
Gene Ontology
AmiGO
QuickGO
PMC
articles
PubMed

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