53:"They contracted with Henry Blair, who had worked at NIH with Brady but left to form the New England Enzyme Center at Tufts University Medical School in Boston. Supported solely by contracts from Brady's lab, Blair set up a lab for large-scale purification and began collecting fresh placentas. In 1981, with NIH getting ready to move into larger clinical trials and biotechnology fever exploding around him, Blair privatized his venture. He launched Genzyme, with the NIH as its major source of revenue."
49:(NIH) were almost ready for a clinical trial for an enzyme replacement therapy for Gaucher's disease that they had been working on for over a decade. They could not purify the enzyme in large enough quantities.
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Blair had started his career in the biotechnology industry working as a technician at Tufts medical school. In 1978 Henry E. Blair, from the NEEC and a team of researchers including Peter G. Pentchev,
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Doogab Yi (2009). "The scientific commons in the marketplace: the industrialization of biomedical materials at the New
England Enzyme Center, 1963–1980".
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and continued to produce the enzymes for the NIH. Genzyme's first office was an old clothing warehouse adjacent to Tufts
Medical School.
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A Flair for the
Business of Medicine: Genzyme founder Henry Blair started his career working as a technician at Tufts medical school
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207:"Genzyme put patients first, and grew to become a multi-billion-dollar company. But empires don't survive on altruism"
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According to Doogab Yi, by the late 1970s NEEC had been transformed into "several commercial biotech companies."
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225:"Gaucher disease: Isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue"
67:, Daniel E. Britton and Susan H. Sorrell from the National Institutes of Health co-authored a paper in the
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Pentchev; Brady, RO; Blair, HE; Britton, DE; Sorrell, SH; et al. (August 1978).
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Proceedings of the
National Academy of Sciences of the United States of America
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The $ 800 Million Pill: The Truth Behind the Cost of New Drugs
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in 1964 as a federally supported biochemical resource center.
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isolating and comparing enzymes in search of a treatment for
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155:, University of California Press,
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282:Michael Rosenwald (August 2010).
319:Biochemistry research institutes
284:"Can Nanotechnology Save Lives?"
178:Bruce Morgan (April 12, 2012),
147:Merrill Goozne (October 2005),
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205:Sara Calabro (1 March 2006),
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47:National Institutes of Health
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78:In 1981 venture capitalist
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23:(NEEC) was created at the
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21:New England Enzyme Center
211:Pharmaceutical Executive
324:Life sciences industry
250:10.1073/pnas.75.8.3970
111:History and Technology
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45:and his colleagues at
86:created the start-up
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29:Boston, Massachusetts
288:Smithsonian Magazine
84:George M. Whitesides
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88:Genzyme
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